nicolynnvila/splicing_epistasis_okgp_cons_nondriver_tcgarec

CONSTRAINED non-drivers with TCGA-recurrent doublets (Panel E) 41,522 cis-double SNV pairs across 220 genes: NOT in OncoKB, LOEUF<0.7, with ≥2 TCGA-clean pairs × ≥5 carriers each. Tests the SYNERGY-depletion hypothesis. Built with the standard paper §2 ¶1-5 methodology: ≤100 nt intra-gene window ≥3 1KG carriers per constituent TopLD r² ≥ 0.2 dropped Greedy 1:1 matched arms keyed on gene + log-rarity bin + distance ±2 nt seed=42 Companion panels:… See the full description on the dataset page: https://huggingface.co/datasets/nicolynnvila/splicing_epistasis_okgp_cons_nondriver_tcgarec.