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nicolynnvila/splicing_epistasis_okgp_cons_nondriver_tcgarec

CONSTRAINED non-drivers with TCGA-recurrent doublets (Panel E) 41,522 cis-double SNV pairs across 220 genes: NOT in OncoKB, LOEUF<0.7, with ≥2 TCGA-clean pairs × ≥5 carriers each. Tests the SYNERGY-depletion hypothesis. Built with the standard paper §2 ¶1-5 methodology: ≤100 nt intra-gene window ≥3 1KG carriers per constituent TopLD r² ≥ 0.2 dropped Greedy 1:1 matched arms keyed on gene + log-rarity bin + distance ±2 nt seed=42 Companion panels:… See the full description on the dataset page: https://huggingface.co/datasets/nicolynnvila/splicing_epistasis_okgp_cons_nondriver_tcgarec.

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Dataset Card

CONSTRAINED non-drivers with TCGA-recurrent doublets (Panel E)

41,522 cis-double SNV pairs across 220 genes: NOT in OncoKB, LOEUF<0.7, with ≥2 TCGA-clean pairs × ≥5 carriers each. Tests the SYNERGY-depletion hypothesis.

Built with the standard paper §2 ¶1-5 methodology:

—≤100 nt intra-gene window
—≥3 1KG carriers per constituent
—TopLD r² ≥ 0.2 dropped
—Greedy 1:1 matched arms keyed on gene + log-rarity bin + distance ±2 nt
—seed=42

Companion panels:

—splicing_epistasis_okgp_cons_driver_tcgarec — Panel D
—splicing_epistasis_okgp_cons_nondriver_tcgarec — Panel E
—splicing_epistasis_okgp_cons_silent_control — Panel F