polyreactivity
jain-clinical-antibody-polyreactivity
Jain Clinical Antibody Polyreactivity Dataset (Novo Nordisk Parity Benchmark)
Dataset Summary
This dataset contains 86 clinical-stage antibody heavy chain variable domain (VH) sequences with binary polyreactivity labels, preprocessed to reproduce the benchmark results from Sakhnini et al. 2025 (Novo Nordisk & University of Cambridge). The original dataset was published by Jain et al. 2017 and contains biophysical measurements for 137 FDA-approved or late-stage… See the full description on the dataset page: https://huggingface.co/datasets/hugging-science/jain-clinical-antibody-polyreactivity.boughter-antibody-polyreactivity
Boughter Antibody Polyreactivity Dataset (Novo Nordisk Preprocessing)
Dataset Summary
This dataset contains 914 antibody heavy chain variable domain (VH) sequences with binary polyreactivity labels, preprocessed according to the methodology described in Sakhnini et al. 2025 (Novo Nordisk & University of Cambridge). The dataset was originally published by Boughter et al. 2020 and contains mouse antibodies with ELISA-based polyreactivity measurements against a panel of 4–7… See the full description on the dataset page: https://huggingface.co/datasets/hugging-science/boughter-antibody-polyreactivity.harvey-nanobody-polyreactivity
Harvey Nanobody Polyreactivity Dataset (Novo Nordisk Preprocessing)
Dataset Summary
This dataset contains 141,021 nanobody (VHH) sequences with binary polyreactivity labels, preprocessed according to the methodology described in Sakhnini et al. 2025 (Novo Nordisk & University of Cambridge). The dataset was originally published by Harvey et al. 2022 and contains synthetic nanobodies assessed by PSR (Poly-Specificity Reagent) assay via FACS sorting and deep sequencing.
This… See the full description on the dataset page: https://huggingface.co/datasets/hugging-science/harvey-nanobody-polyreactivity.