Modelpublic

pyaging/systemsageheart

sourceHugging Facemitupdated 1mo agoView on Hugging Face

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Model Card

systemsageheart

Heart-system component of Systems Age: a whole-blood DNAm score built from cardiovascular-system biomarkers and mortality training, returned on an age-like scale.


Predicts	cardiovascular-system biological age
Species	Homo sapiens
Tissue	whole blood
Data type	DNA methylation
Model type	PCA + elastic net regression
Year	2025

Use with pyaging

python

import pyaging as pya

pya.pred.predict_age(adata, ["systemsageheart"])

Browse every clock in the pyaging Clock Catalogue.

Citation

Sehgal, R., Markov, Y., Qin, C., et al. (2025). Systems Age: a single blood methylation test to quantify aging heterogeneity across 11 physiological systems. Nature Aging, 5, 1880–1896.

https://doi.org/10.1038/s43587-025-00958-3