pyaging/replitali

replitali

Final RepliTali model estimating relative cumulative replicative history from methylation in common partially methylated domains; it was fitted to normalized population doublings across serially cultured primary human cells.

Use with pyaging

import pyaging as pya

pya.pred.predict_age(adata, ["replitali"])

Browse every clock in the pyaging Clock Catalogue.

Citation

Endicott, J.L., Nolte, P.A., Shen, H. & Laird, P.W. Cell division drives DNA methylation loss in late-replicating domains in primary human cells. Nature Communications 13, 6659 (2022).

https://doi.org/10.1038/s41467-022-34268-8