pyaging/phenoage

phenoage

Clinical Phenotypic Age combines chronological age with nine blood biomarkers selected by penalized mortality regression and expresses mortality risk as an equivalent age in years. C-reactive protein is supplied raw in mg/dL and natural-log-transformed inside the clock, with readings at or below 0.01 mg/dL clamped to that floor; before pyaging 0.5.0 the feature was named log_crp and the caller had to supply the log. Continuing to pass a pre-logged value biases the estimate downward: any pre-logged CRP below 1.01 mg/dL, which covers most healthy adults, lands on the clamp floor and returns the same answer as omitting CRP entirely — about four years younger than the correct value for a typical adult, so the estimate reads healthier than it is.

Use with pyaging

import pyaging as pya

pya.pred.predict_age(adata, ["phenoage"])

Browse every clock in the pyaging Clock Catalogue.

Citation

Levine, M. E., et al. "An epigenetic biomarker of aging for lifespan and healthspan." Aging 10.4 (2018): 573-591.

https://doi.org/10.18632/aging.101414