vladak/string_ppi_human_1M
STRING PPI Human 1M This dataset contains 1 million human protein–protein interactions (PPIs) derived from STRING v11.5. Columns: seq_a, seq_b: Amino acid sequences of the interacting proteins (≤2048 AA). seq_name_a, seq_name_b: Protein names from STRING. score: Combined score from STRING (0–1000, normalized to 0–1). This score integrates various evidence channels (experimental data, text mining, co-expression, etc.) into a single confidence metric. label: Binary interaction… See the full description on the dataset page: https://huggingface.co/datasets/vladak/string_ppi_human_1M.
STRING PPI Human 1M
This dataset contains 1 million human protein–protein interactions (PPIs) derived from STRING v11.5.
Columns:
seq_a,seq_b: Amino acid sequences of the interacting proteins (≤2048 AA).seq_name_a,seq_name_b: Protein names from STRING.score: Combined score from STRING (0–1000, normalized to 0–1). This score integrates various evidence channels (experimental data, text mining, co-expression, etc.) into a single confidence metric.label: Binary interaction label.1: High-confidence positive interaction (STRING experimental score > 0.7).0: Low-confidence negative interaction (STRING experimental score < 0.2).
Processing Steps:
- Downloaded human interactions from STRING (
9606.protein.links.detailed.v11.5.txt.gz). - Filtered by experimental score thresholds for positives/negatives.
- Retrieved protein sequences from UniProt by matching STRING protein names.
- Excluded sequences longer than 2048 amino acids.
- Balanced top and bottom 500k interactions by combined score.
Useful for training models for binary PPI prediction or embedding-based methods.
Source: STRING Database v11.5.