referencesource/hvac-component-refrigerant-compatibility

HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant

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• —Last verified: 2026-08-11
• —Stale after: 2027-08-11 (past this date, prefer the canonical copy — it re-verifies on a cadence this snapshot does not)
• —Records: 109

Which refrigerant substitutes for which in air conditioning, heat pump and refrigeration equipment, drawn from the EPA SNAP substitutes list, compressor-manufacturer bulletins (Copeland) and refrigerant-manufacturer replacement guides (Chemours, Honeywell, Arkema). Each record carries the ASHRAE safety classification, GWP, whether the substitute is approved for retrofit or new equipment only, and the compatible lubricant. Answers 'can I put R-454B in an R-410A system', 'what replaces R-22 without changing the oil', and 'is this substitute EPA-acceptable' — questions where the wrong answer damages equipment or breaks federal rules.

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Licence position

Factual compilation with source citations. EPA SNAP substitute listings are US government work (public domain). Manufacturer figures (Copeland, Chemours, Honeywell, Trane, Arkema) are facts taken with short attributed quotes linking back to the published guide.

Facts are not copyrightable; what this dataset takes from each source is a fact plus a short attributed quote linking back to the page that states it.

Sources

• —https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps
• —https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11
• —https://www.federalregister.gov/documents/2025/11/10/2025-19812/protection-of-stratospheric-ozone-listing-of-substitutes-under-the-significant-new-alternatives
• —https://www.chemours.com/en/-/media/files/freon/opteon-freon-general-replacement-guide.pdf
• —https://www.epa.gov/sites/default/files/documents/ChoosingRightR22_Retrofit.pdf
• —https://www.freon.com/en/-/media/files/freon/freon-mo99-faq.pdf
• —https://forane.arkema.com/en/forane-refrigerants/forane-retrofits/the-drop-in-myth/
• —https://prod-edam.honeywell.com/content/dam/honeywell-edam/pmt/oneam/en-us/refrigerants/documents/pmt-am-solstice-454b-applications-guide.pdf
• —https://www.shareddocs.com/hvac/docs/1006/Public/06/570-178.pdf
• —https://www.trane.com/content/dam/Trane/Commercial/global/products-systems/equipment/unitary/split-systems/rauj-cauj-20-to-120-tons/SS-APG018A-EN_11102024.pdf

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