nicolynnvila/splicing_epistasis_okgp_tcga_silent_control

Splicing epistasis — TCGA-silent control panel (Panel C) 143,408 cis-double SNV pairs (71,704 observed + 71,704 unobserved-matched) in 1000 Genomes across 719 randomly sampled protein-coding genes that have zero TCGA double-mutation pairs in tcga_de_novo_pairs_clean_relaxed.csv (the broad TCGA pair pool). Built as the null arm of a three-panel strict test. These genes show no evidence of recurrent doublet events in TCGA — the prediction is that they should show no 1KG depletion… See the full description on the dataset page: https://huggingface.co/datasets/nicolynnvila/splicing_epistasis_okgp_tcga_silent_control.