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nicolynnvila/splicing_epistasis_okgp_cons_silent_control

CONSTRAINED TCGA-silent control (Panel F) 84,848 cis-double SNV pairs across 261 randomly sampled genes: LOEUF<0.7, ZERO TCGA pairs in any tier. Null reference. Built with the standard paper §2 ¶1-5 methodology: ≤100 nt intra-gene window ≥3 1KG carriers per constituent TopLD r² ≥ 0.2 dropped Greedy 1:1 matched arms keyed on gene + log-rarity bin + distance ±2 nt seed=42 Companion panels: splicing_epistasis_okgp_cons_driver_tcgarec — Panel D… See the full description on the dataset page: https://huggingface.co/datasets/nicolynnvila/splicing_epistasis_okgp_cons_silent_control.

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Dataset Card

CONSTRAINED TCGA-silent control (Panel F)

84,848 cis-double SNV pairs across 261 randomly sampled genes: LOEUF<0.7, ZERO TCGA pairs in any tier. Null reference.

Built with the standard paper §2 ¶1-5 methodology:

—≤100 nt intra-gene window
—≥3 1KG carriers per constituent
—TopLD r² ≥ 0.2 dropped
—Greedy 1:1 matched arms keyed on gene + log-rarity bin + distance ±2 nt
—seed=42

Companion panels:

—splicing_epistasis_okgp_cons_driver_tcgarec — Panel D
—splicing_epistasis_okgp_cons_nondriver_tcgarec — Panel E
—splicing_epistasis_okgp_cons_silent_control — Panel F