jablonkagroup/peptides_nonfouling

Dataset Details

Dataset Description

Non-fouling is defined as resistance to non-specific interactions. A non-fouling peptide (positive example) is defined using the mechanism proposed in ref white2012decoding. Briefly, ref white2012decoding, showed that the exterior surfaces of proteins have a significantly different frequency of amino acids, and this increases in aggregation prone environments, like the cytoplasm. Synthesizing self-assembling peptides that follow this amino acid distribution and coating surfaces with the peptides creates non-fouling surfaces. This pattern was also found inside chaperone proteins, another area where resistance to non-specific interactions is important (ref white2012role).

• —Curated by:
• —License: CC BY 4.0

Dataset Sources

• —corresponding publication
• —data source

Citation

<!-- If there is a paper or blog post introducing the dataset, the APA and Bibtex information for that should go in this section. -->

BibTeX:

@article{white2012decoding,
        title={Decoding nonspecific interactions from nature},
        author={White, Andrew D and Nowinski, Ann K and Huang, Wenjun and Keefe,
          Andrew J and Sun, Fang and Jiang, Shaoyi},
        journal={Chemical Science},
        volume={3},
        number={12},
        pages={3488--3494},
        year={2012},
        publisher={Royal Society of Chemistry}
@article{barrett2018classifying,
        title={Classifying antimicrobial and multifunctional peptides with Bayesian network models},
        author={Barrett, Rainier and Jiang, Shaoyi and White, Andrew D},
        journal={Peptide Science},
        volume={110},
        number={4},
        pages={e24079},
        year={2018},
        publisher={Wiley Online Library}