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jablonkagroup/cyp_p450_2c19_inhibition_veith_et_al

Dataset Details Dataset Description The CYP P450 genes are essential in the breakdown (metabolism) of various molecules and chemicals within cells. A drug that can inhibit these enzymes would mean poor metabolism to this drug and other drugs, which could lead to drug-drug interactions and adverse effects. Specifically, the CYP2C19 gene provides instructions for making an enzyme of the endoplasmic reticulum, which is involved in protein processing and transport.… See the full description on the dataset page: https://huggingface.co/datasets/jablonkagroup/cyp_p450_2c19_inhibition_veith_et_al.

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Dataset Details

Dataset Description

The CYP P450 genes are essential in the breakdown (metabolism) of various molecules and chemicals within cells. A drug that can inhibit these enzymes would mean poor metabolism to this drug and other drugs, which could lead to drug-drug interactions and adverse effects. Specifically, the CYP2C19 gene provides instructions for making an enzyme of the endoplasmic reticulum, which is involved in protein processing and transport.

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  • —License: CC BY 4.0

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Citation

<!-- If there is a paper or blog post introducing the dataset, the APA and Bibtex information for that should go in this section. -->

BibTeX:

bibtex
@article{Veith2009,
doi = {10.1038/nbt.1581},
url = {https://doi.org/10.1038/nbt.1581},
year = {2009},
month = oct,
publisher = {Springer Science and Business Media LLC},
volume = {27},
number = {11},
pages = {1050--1055},
author = {Henrike Veith and Noel Southall and Ruili Huang and Tim James
and Darren Fayne and Natalia Artemenko and Min Shen and James Inglese
and Christopher P Austin and David G Lloyd and Douglas S Auld},
title = {Comprehensive characterization of cytochrome P450 isozyme selectivity
across chemical libraries},
journal = {Nature Biotechnology}