donb-hf/secondary-screen-dose-response-curve-parameters

Citation

DepMap, Broad; Corsello, Steven; Kocak, Mustafa; Golub, Todd (2019). PRISM Repurposing 19Q4 Dataset. figshare. Dataset.

Current dataset: https://doi.org/10.6084/m9.figshare.9393293.v4

General guidance: https://doi.org/10.1101/730119

Dataset specific README: prism_repurposing_secondary

Dataset Fields

• —broad_id: ID used to identify drug-batch combinations
• —name: Name of the drug
• —depmap_id: ID to identify a cell line
• —ccle_name: ID to identify a cell line
• —screen_id: ID to identify a screen
• —upper_limit: Limit of the curve as dose approaches infinity
• —lower_limit: Limit of the curve as dose approaches zero
• —slope: Slope of the dose-response curve
• —r2: Goodness of fit measure between dose-response curve and replicate viability data
• —auc: Area under the dose-response curve
• —ec50: Dose at the inflection point of the dose-response curve
• —ic50: Dose that corresponds to a viability of 50 on the dose-response curve
• —moa: Broad Repurposing Hub mechanism of action annotation
• —target: Broad Repurposing Hub gene target annotation
• —disease_area: Broad Repurposing Hub disease area annotation
• —indication: Broad Repurposing Hub indication annotation
• —smiles: Simplified Molecular Input Line Entry System (SMILES) molecular identifier
• —phase: Broad Repurposing Hub latest clinical phase annotation
• —passed_str_profiling: Indicator for problems identified by STR profiling