YannisTevissen/sma-bforsma-reported-biomarkers

BforSMA Reported Biomarkers

This repository contains the eight documents released with the Biomarkers for Spinal Muscular Atrophy (BforSMA) clinical study.

The study involved 108 children with SMA and 22 controls and reported candidate proteins, metabolites, and transcripts. The public Figshare package is valuable, but it consists of report/protocol documents and tables—not a ready-to-train participant-by-feature matrix. The repository name says reported biomarkers to make that distinction explicit.

The repository contains five tables, two appendices, and one list. The accompanying MANIFEST.csv records each Figshare file identifier, filename, byte size, published MD5, SHA-256 checksum, and CC BY 4.0 licence. scripts/download_original.py retrieves and verifies the package. Any machine-readable table extracted later should retain its document, table, row, and column provenance.

Appropriate use

• —systematic review and candidate-biomarker extraction;
• —ontology mapping across proteins, metabolites, and transcripts;
• —a transparent document-to-table reproduction exercise.

Do not present the package as 130 freely reusable patient rows, and do not use reported group findings as a diagnostic model.

Source citation and attribution

• —Canonical source: BforSMA dataset on Figshare
• —Licence: CC BY 4.0

Finkel RS, Crawford TO, Swoboda KJ, et al. (2012). Candidate Proteins, Metabolites and Transcripts in the Biomarkers for Spinal Muscular Atrophy (BforSMA) Clinical Study. PLOS ONE, 7(4), e35462. https://doi.org/10.1371/journal.pone.0035462

The Figshare package is CC BY 4.0. Cite the Figshare item and the underlying PLOS study when reusing the documents.

All eight documents are redistributed unmodified, and their checksums in MANIFEST.csv match the published Figshare files.