Fernandosr85/adaption-rit1-vus-research-tiers

This dataset is a remastered version prepared using Adaption's Adaptive Data platform.

adaption-rit1vusresearch_tiers

This dataset contains research-level prioritization assessments for RIT1 missense variants associated with Noonan Syndrome 8 (NS8). Each entry provides a structured analysis including source-derived investigation tiers, scores, and evidence summaries based on computational predictors, population frequency, and structural domain context. The data explicitly preserves pipeline-generated labels for research follow-up while disclaiming clinical classification.

Dataset size

There are 178 data points in this dataset. This is an instruction tuning dataset.

Quality of Remastered Dataset

The final quality is A, with a relative quality improvement of 32.9%.

Domain

• —Science (73%)
• —Medical (15%)
• —Other (12%)

Language

• —English (100%)

Tone

• —Technical (89%)
• —Analytical (12%)

Evaluation Results

• —Quality Gains: <img src="https://proteus-prod-public.s3.us-east-1.amazonaws.com/temp/721b97a1-d987-4b38-8f36-1108fd32289e.png" alt="QualityGains" style="max-width: 50%; display: block; margin-left: auto; margin-right: auto;" />

• —Grade Improvement: <img src="https://proteus-prod-public.s3.us-east-1.amazonaws.com/temp/8ff3a29f-d522-43f3-b95d-2f0cd7494056.png" alt="Grade" style="max-width: 50%; display: block; margin-left: auto; margin-right: auto;" />

• —Percentile Chart: <img src="https://proteus-prod-public.s3.us-east-1.amazonaws.com/temp/5659ca3b-6a01-4890-bb2d-2a63a995e78f.png" alt="Percentile Chart" style="max-width: 50%; display: block; margin-left: auto; margin-right: auto;" />