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Evenli2026/uce-spleen-granulocyte-LDG-like

LDG-like (low-density granulocyte proxy) analysis Caveat (critical) True LDGs/LDNs are defined by density-gradient fractionation. This upload is a transcriptional LDG-like proxy in spleen scRNA granulocytes: immature granule + immunosuppressive (Arg1/2, Acod1, Olr1, Cd274) + type-I IFN ISGs versus mature neutrophil program (Retnlg, Ly6g, Cd177, …). Main finding LDG-like cells can be separated transcriptionally and expand in KO, but they are not the… See the full description on the dataset page: https://huggingface.co/datasets/Evenli2026/uce-spleen-granulocyte-LDG-like.

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LDG-like (low-density granulocyte proxy) analysis

Caveat (critical)

True LDGs/LDNs are defined by density-gradient fractionation. This upload is a transcriptional LDG-like proxy in spleen scRNA granulocytes: immature granule + immunosuppressive (Arg1/2, Acod1, Olr1, Cd274) + type-I IFN ISGs versus mature neutrophil program (Retnlg, Ly6g, Cd177, …).

Main finding

LDG-like cells can be separated transcriptionally and expand in KO, but they are not the sole driver: under the primary tertile rule, shares of positive Δ are roughly LDG-like 30.7% | Intermediate 32.9% | NDG-like (mature) 36.4%.

Strict LDG gate (high LDG z and LDG≫NDG) → LDG-like share drops to ~6%.

Overlap with prior subtypes: Proliferating precursor & MDSC-like / activated enrich LDG-like; Mature neutrophil enrich NDG-like.

Files

  • —figures/FigS_LDG_*
  • —tables/LDG_*
  • —LDG_REPORT.md, RESULTS_section16.md

Updated: 2026-08-08

Related

  • —Mechanistic 5-module plan: https://huggingface.co/datasets/Evenli2026/uce-spleen-mechanistic-logic