ClarusC64/alphafold-interface-decoherence-under-stress-detection-v0.1
What this dataset tests Whether a model can detectstress-induced interface decoherencebefore full dissociation. Stress modes covered pH shiftheat stressoxidative stress The failure mode Contact maps stop predicting bindingand cross-interface signal transmission weakens. Inputs stress_typestress_level baseline_interface_coherencebaseline_kd_nMbaseline_contact_stabilitybaseline_allosteric_cross_interface_score… See the full description on the dataset page: https://huggingface.co/datasets/ClarusC64/alphafold-interface-decoherence-under-stress-detection-v0.1.
What this dataset tests
Whether a model can detect stress-induced interface decoherence before full dissociation.
Stress modes covered
pH shift heat stress oxidative stress
The failure mode
Contact maps stop predicting binding and cross-interface signal transmission weakens.
Inputs
stresstype stresslevel
baselineinterfacecoherence baselinekdnM baselinecontactstability baselineallostericcrossinterfacescore
stressedinterfacecoherence stressedkdnM contactlossfraction
Required outputs
decoherenceonsetscore contactlossnodes functionalriskflag stabilization_hint
Task
Given baseline and stressed measurements predict:
- early decoherence onset score
- which interface nodes failed
- whether function risk is triggered
- the first stabilization move
Use cases
Biologics stability screening Synthetic complex design Cell-condition robustness testing Early warning for interface failure