ClarusC64/ABX-RM-008_persister_cell_synchronization-v0.1

ABX-RM-008 Persister Cell Synchronization

Purpose

Detect coordinated rises in persister fraction that coincide with kill curve plateaus while MIC stays stable.

Core pattern

• —persister_frac crosses a wave threshold and stays elevated
• —kill_log10 gain collapses to a plateau
• —micdrugmg_L stays near baseline

Files

• —data/train.csv
• —data/test.csv
• —scorer.py

Schema

Each row is one timepoint in a within strain series.

Required columns

• —row_id
• —series_id
• —timepoint_h
• —organism
• —strain_id
• —drug_name
• —persister_frac
• —kill_log10
• —exposure_index
• —micdrugmg_L
• —media
• —assay_method
• —source_type
• —persisterwavesignal
• —earliestpersisterwave

Labels

• —persisterwavesignal
• —1 for rows at or after the first detected wave onset

• —earliestpersisterwave
• —1 only for the first detected wave row in that series

Scorer logic in v1

• —baseline is timepoint 0
• —candidate wave onset at time t when
• —persister_frac at least 0.12
• —persister_frac remains at least 0.12 at the next timepoint
• —kill_log10 gain vs previous timepoint at most 0.20
• —MIC during the wave window at most 2x baseline
• —exclude spike then snapback artifacts

Evaluation

Run

• —python scorer.py --path data/test.csv