ClarusC64/ABX-HT-008_phototoxicity_activation-v0.1

ABX-HT-008 Phototoxicity Activation

Purpose

Detect early phototoxicity activation when sunlight interaction stops behaving predictably.

Core pattern

• —hoststressindex high
• —drugexposureindex high
• —uvdoseindex high
• —phototoxcoherenceindex drops
• —reactionrisevs_expected stays high
• —laterseverephototox_flag appears

Files

• —data/train.csv
• —data/test.csv
• —scorer.py

Schema

Each row is one timepoint in a within series treatment course.

Required columns

• —row_id
• —series_id
• —treatment_day
• —host_model
• —drug
• —drugexposureindex
• —uv_index
• —uvexposurehours
• —uvdoseindex
• —expecteduvdose_index
• —uvdosedeviation
• —skinreactionscore
• —expectedskinreaction_score
• —reactionrisevs_expected
• —phototoxcoherenceindex
• —hoststressindex
• —laterseverephototox_flag
• —assay_method
• —source_type
• —phototoxicity_signal
• —earliest_phototoxicity

Labels

• —phototoxicity_signal
• —1 for rows at or after first confirmed activation onset

• —earliest_phototoxicity
• —1 only for the first onset row in that series

Scorer logic in v1

• —exclude series with high baseline skin reaction
• —candidate onset point
• —hoststressindex at least 0.80
• —drugexposureindex at least 0.80
• —uvdoseindex at least 0.35
• —phototoxcoherenceindex at most 0.40
• —reactionrisevs_expected at least 2.5 for two consecutive points
• —ignore one point reaction spike then recovery artifacts
• —confirmation
• —laterseverephototox_flag equals 1 later in series

Evaluation

Run

• —python scorer.py --path data/test.csv