ClarusC64/ABX-HT-003_hepatic_metabolism_saturation-v0.1

ABX-HT-003 Hepatic Metabolism Saturation

Purpose

Detect early hepatic metabolism saturation when PK and liver enzyme response stop tracking expected behavior before hepatotoxicity appears.

Core pattern

• —stress_index high
• —exposure_index high
• —hepaticcoherenceindex drops
• —conc_deviation rises
• —clearancedropvs_expected rises
• —laterhepatotoxflag appears

Files

• —data/train.csv
• —data/test.csv
• —scorer.py

Schema

Each row is one timepoint in a within series time course.

Required columns

• —row_id
• —series_id
• —timepoint_h
• —host_model
• —drug
• —drugconcmg_L
• —expecteddrugconcmgL
• —conc_deviation
• —clearanceLh
• —expectedclearanceL_h
• —clearancedropvs_expected
• —ALTUL
• —expectedALTU_L
• —ALTrisevs_expected
• —hepaticcoherenceindex
• —exposure_index
• —stress_index
• —laterhepatotoxflag
• —assay_method
• —source_type
• —hepaticsaturationsignal
• —earliesthepaticsaturation

Labels

• —hepaticsaturationsignal
• —1 for rows at or after first confirmed saturation onset

• —earliesthepaticsaturation
• —1 only for the first onset row in that series

Scorer logic in v1

• —exclude series with high baseline ALT
• —candidate onset point
• —stress_index at least 0.80
• —exposure_index at least 0.80
• —hepaticcoherenceindex at most 0.40
• —conc_deviation at least 2.0
• —clearancedropvs_expected at least 2.0
• —for two consecutive points
• —ignore one point ALT spike then recovery artifacts
• —confirmation
• —laterhepatotoxflag equals 1 later in series

Evaluation

Run

• —python scorer.py --path data/test.csv