ClarusC64/ABX-CT-010_cycling_strategy_collapse-v0.1

ABX-CT-010 Cycling Strategy Collapse

Purpose

Detect when antibiotic rotation stops controlling resistance.

Core pattern

• —stress_index high
• —cycleexposureindex high
• —burden_gap stays high across different cycle drugs
• —mdr_marker rises and stays high
• —later clinicalfailureflag appears

Files

• —data/train.csv
• —data/test.csv
• —scorer.py

Schema

Each row is one cycle timepoint in a within series rotation history.

Required columns

• —row_id
• —series_id
• —timepoint_d
• —cycle_id
• —drugincycle
• —stress_index
• —cycleexposureindex
• —populationresistanceburden
• —expectedburdenunder_cycling
• —burden_gap
• —mdr_marker
• —mictoactivedrugfoldvsbaseline
• —clinicalfailureflag
• —source_type
• —cyclingcollapsesignal
• —earliestcyclingcollapse

Labels

• —cyclingcollapsesignal
• —1 for rows at or after first confirmed collapse point

• —earliestcyclingcollapse
• —1 only for the first collapse row in that series

Scorer logic in v1

• —candidate collapse point
• —stress_index at least 0.80
• —cycleexposureindex at least 0.80
• —burden_gap at least 0.25 at two consecutive points
• —consecutive points must be different drugincycle values
• —mdr_marker at least 0.60 and up at least 0.10 vs baseline
• —exclude burden_gap spike then snapback artifacts
• —confirmation
• —clinicalfailureflag equals 1 later in series

Evaluation

Run

• —python scorer.py --path data/test.csv