ClarusC64/ABX-CT-008_toxicity_additivity_warning-v0.1

ABX-CT-008 Toxicity-Additivity Warning

Purpose

Detect when combined toxicity exceeds simple additivity from each drug alone.

Core pattern

• —stress_index high
• —exposure indices high
• —tox_excess rises and stays high
• —later severetoxicityflag appears

Files

• —data/train.csv
• —data/test.csv
• —scorer.py

Schema

Each row is one timepoint in a within series time course.

Required columns

• —row_id
• —series_id
• —timepoint_h
• —host_model
• —toxbiomarkername
• —toxbiomarkerunits
• —stress_index
• —exposureaindex
• —exposurebindex
• —baselinetoxbiomarker
• —monoAtoxdelta
• —monoBtoxdelta
• —expectedadditivetox
• —observedcombotox
• —tox_excess
• —severetoxicityflag
• —drug_a
• —drug_b
• —source_type
• —toxicityadditivitywarning_signal
• —earliesttoxicityadditivity_warning

Labels

• —toxicityadditivitywarning_signal
• —1 for rows at or after first confirmed warning point

• —earliesttoxicityadditivity_warning
• —1 only for the first warning row in that series

Scorer logic in v1

• —baselinetoxbiomarker must be below a simple ceiling
• —candidate warning point
• —stress_index at least 0.80
• —exposureaindex and exposurebindex at least 0.80
• —tox_excess at least 0.40 at two consecutive timepoints
• —exclude tox_excess spike then snapback artifacts
• —confirmation
• —severetoxicityflag equals 1 later in series

Evaluation

Run

• —python scorer.py --path data/test.csv