ClarusC64/ABX-CT-005_resistance_suppression_failure-v0.1

ABX-CT-005 Resistance Suppression Failure

Purpose

Detect when a combination stops suppressing resistant subpopulations.

Core pattern

• —stress_index high
• —comboexposureindex high
• —resistantsubpopfrac rises and keeps rising
• —mono MICs stay below cutoffs at onset
• —latercombofailure_flag appears later in the series

Files

• —data/train.csv
• —data/test.csv
• —scorer.py

Schema

Each row is one timepoint in a within strain series.

Required columns

• —row_id
• —series_id
• —timepoint_h
• —organism
• —strain_id
• —drug_a
• —drug_b
• —stress_index
• —comboexposureindex
• —resistantsubpopfrac
• —resistantsubpopgrowth_rate
• —monoAmicmg_L
• —monoBmicmg_L
• —monoAresistantcutoffmgL
• —monoBresistantcutoffmgL
• —latercombofailure_flag
• —media
• —assay_method
• —source_type
• —suppressionfailuresignal
• —earliestsuppressionfailure

Labels

• —suppressionfailuresignal
• —1 for rows at or after first detected suppression failure

• —earliestsuppressionfailure
• —1 only for the first detected row in that series

Scorer logic in v1

• —baseline resistantsubpopfrac must be low
• —candidate failure point
• —stress_index at least 0.80
• —comboexposureindex at least 0.80
• —resistantsubpopfrac at least 0.05
• —resistantsubpopfrac increases again at next timepoint
• —mono MICs below cutoffs at onset
• —confirmation
• —latercombofailure_flag equals 1 later in series

Evaluation

Run

• —python scorer.py --path data/test.csv