ClarusC64/ABX-CT-001_synergy_score_decay-v0.1

ABX-CT-001 Synergy Score Decay

Purpose

Detect loss of combination synergy before monotherapy resistance appears.

Core pattern

• —stress_index high
• —synergy_gap rises and stays high
• —mono MICs stay below cutoffs during the early window
• —later at least one mono MIC crosses its cutoff

Files

• —data/train.csv
• —data/test.csv
• —scorer.py

Schema

Each row is one timepoint in a within strain series.

Required columns

• —row_id
• —series_id
• —timepoint_h
• —organism
• —strain_id
• —drug_a
• —drug_b
• —stress_index
• —synergy_score
• —expectedsynergyscore
• —synergy_gap
• —monoAmicmg_L
• —monoBmicmg_L
• —monoAresistantcutoffmgL
• —monoBresistantcutoffmgL
• —media
• —assay_method
• —source_type
• —synergydecaysignal
• —earliestsynergydecay

Labels

• —synergydecaysignal
• —1 for rows at or after the first confirmed synergy decay point

• —earliestsynergydecay
• —1 only for the first detected decay row in that series

Scorer logic in v1

• —baseline is timepoint 0
• —candidate decay point
• —stress_index at least 0.80
• —synergy_gap at least 0.30 at two consecutive timepoints
• —mono MICs below cutoffs and no more than 2x baseline
• —exclude synergy_gap drop spike then snapback artifacts
• —confirmation
• —later monoA or monoB MIC crosses its cutoff

Evaluation

Run

• —python scorer.py --path data/test.csv