mhjiang0408/MAC_Bench
MAC: A Live Benchmark for Multimodal Large Language Models in Scientific Understanding 📋 Dataset Description MAC is a comprehensive live benchmark designed to evaluate multimodal large language models (MLLMs) on scientific understanding tasks. The dataset focuses on scientific journal cover understanding, providing challenging testbeds for assessing visual-textual comprehension capabilities of MLLMs in academic domains. 🎯 Tasks 1. Image-to-Text… See the full description on the dataset page: https://huggingface.co/datasets/mhjiang0408/MAC_Bench.
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1journal,id,question,cover_image,answer,option_A,option_A_path,option_A_embedding_name,option_A_embedding_id,option_B,option_B_path,option_B_embedding_name,option_B_embedding_id,option_C,option_C_path,option_C_embedding_name,option_C_embedding_id,option_D,option_D_path,option_D_embedding_name,option_D_embedding_id,split2Journal of Chemical Theory and Computation,2025_1,Which of the following options best describe the cover story?,s-molecular dynamics simulations and umbrella sampling simulations allow the rationalization of New Delhi metallo-β-lactamase 1 enzyme inhibition by ebselen and ebsulfur to contrast antibiotic resistance. The role of chalcogen,D,MAC_Bench/ACS/Cover/Journal of Chemical Theory and Computation/2022_11.png,MAC_Bench/ACS/Cover/Journal of Chemical Theory and Computation/2022_11.png,vith,2022_11.txt,MAC_Bench/ACS/Cover/Journal of Chemical Theory and Computation/2020_1.png,MAC_Bench/ACS/Cover/Journal of Chemical Theory and Computation/2020_1.png,vitg,2020_1.txt,MAC_Bench/ACS/Cover/Journal of Chemical Theory and Computation/2023_7.png,MAC_Bench/ACS/Cover/Journal of Chemical Theory and Computation/2023_7.png,clip,2023_7.txt,MAC_Bench/ACS/Cover/Journal of Chemical Theory and Computation/2025_1.png,MAC_Bench/ACS/Cover/Journal of Chemical Theory and Computation/2025_1.png,groundtruth,2025_1.txt,train3Cancer Cell,43_2,Which of the following options best describe the cover story?,"On the cover: The cover illustrates how glioblastoma (GBM) aligns its growth with4the brain's daily rhythms. Inspired by artist Sophie Taeuber-Arp and designed by Dr.5Olivia Walch, this visual highlights the daytime tumor growth driven by the circadian6surge in glucocorticoids (green dots). Gonzalez-Aponte et al. discover that blocking circadian regulation of glucocorticoid receptor signaling7slows GBM proliferation in both mouse and human GBM models. Targeting circadian mechanisms8to combat GBM holds great promise and has significant implications for understanding9how the circadian system may influence cancer progression, both within the brain and10beyond.",D,MAC_Bench/Cell/Cover/Cancer Cell/43_1.png,MAC_Bench/Cell/Cover/Cancer Cell/43_1.png,clip,43_1.txt,MAC_Bench/Cell/Cover/Cancer Cell/39_6.png,MAC_Bench/Cell/Cover/Cancer Cell/39_6.png,ave_2,39_6.txt,MAC_Bench/Cell/Cover/Cancer Cell/40_7.png,MAC_Bench/Cell/Cover/Cancer Cell/40_7.png,ave_3,40_7.txt,MAC_Bench/Cell/Cover/Cancer Cell/43_2.png,MAC_Bench/Cell/Cover/Cancer Cell/43_2.png,groundtruth,43_2.txt,train11Industrial & Engineering Chemistry Research,2024_43,Which of the following options best describe the cover story?,"Phenolation is introduced as a simple yet very efficient modification strategy to improve the reactivity of hydrolysis lignin, resulting in better-defined bioaromatic fractions that are suitable for the",C,MAC_Bench/ACS/Cover/Industrial & Engineering Chemistry Research/2024_45.png,MAC_Bench/ACS/Cover/Industrial & Engineering Chemistry Research/2024_45.png,vitg,2024_45.txt,MAC_Bench/ACS/Cover/Industrial & Engineering Chemistry Research/2023_29.png,MAC_Bench/ACS/Cover/Industrial & Engineering Chemistry Research/2023_29.png,vith,2023_29.txt,MAC_Bench/ACS/Cover/Industrial & Engineering Chemistry Research/2024_43.png,MAC_Bench/ACS/Cover/Industrial & Engineering Chemistry Research/2024_43.png,groundtruth,2024_43.txt,MAC_Bench/ACS/Cover/Industrial & Engineering Chemistry Research/2024_46.png,MAC_Bench/ACS/Cover/Industrial & Engineering Chemistry Research/2024_46.png,clip,2024_46.txt,val12Trends in Endocrinology & Metabolism,35_4,Which of the following options best describe the cover story?,"Selenium is an essential trace element associated with both beneficial13and detrimental health effects. This month, Schomburg and colleagues (pp. 781–792)14review the current evidence suggesting a sexual dimorphism in the relationship15between selenium and diabetes, as high blood concentrations of this element have16been associated with an increased risk in men but a decreased risk in women,17particularly for gestational diabetes mellitus during pregnancy. The cover picture18highlights the fascinating interaction between selenium, diabetes and sex. Selenium19is20named after the Greek goddess of the moon and is depicted accordingly. She shines21favourably on women when it comes to protection from disease, particularly the risk22of gestational diabetes, while too much exposure could pose an additional diabetes23risk for sweet-toothed men. Cover credit: Katja May.",C,MAC_Bench/Cell/Cover/Trends in Endocrinology & Metabolism/35_3.png,MAC_Bench/Cell/Cover/Trends in Endocrinology & Metabolism/35_3.png,clip,35_3.txt,MAC_Bench/Cell/Cover/Trends in Endocrinology & Metabolism/35_2.png,MAC_Bench/Cell/Cover/Trends in Endocrinology & Metabolism/35_2.png,vith,35_2.txt,MAC_Bench/Cell/Cover/Trends in Endocrinology & Metabolism/35_4.png,MAC_Bench/Cell/Cover/Trends in Endocrinology & Metabolism/35_4.png,groundtruth,35_4.txt,MAC_Bench/Cell/Cover/Trends in Endocrinology & Metabolism/35_9.png,MAC_Bench/Cell/Cover/Trends in Endocrinology & Metabolism/35_9.png,ave_2,35_9.txt,train24Nature Photonics,18_2,Which of the following options best describe the cover story?,"Ultra-intense Compton scattering25Artistic impression of a nonlinear Compton scattering experiment in which an electron bunch (blue) is accelerated by a laser wakefield to multi-gigaelectron volt energy and then collides with an ultra-intense petawatt laser pulse (red) and generates a strong gamma-ray beam (purple).26See Mirzaie et al.27Image: Ghazal Barati, Saeid Mirzaei and Mohammad Mirzaie (Center for Relativistic Laser Science). Cover design: Bethany Vukomanovic",C,MAC_Bench/Nature/Cover/Nature Photonics/19_2.png,MAC_Bench/Nature/Cover/Nature Photonics/19_2.png,clip,19_2.txt,MAC_Bench/Nature/Cover/Nature Photonics/16_7.png,MAC_Bench/Nature/Cover/Nature Photonics/16_7.png,vith,16_7.txt,MAC_Bench/Nature/Cover/Nature Photonics/18_2.png,MAC_Bench/Nature/Cover/Nature Photonics/18_2.png,groundtruth,18_2.txt,MAC_Bench/Nature/Cover/Nature Photonics/16_3.png,MAC_Bench/Nature/Cover/Nature Photonics/16_3.png,vitg,16_3.txt,train28NATURE METHODS,21_11,Which of the following options best describe the cover story?,"Smart lattice light-sheet microscopy29Smart lattice light-sheet microscopy captures rare cellular events. The image shows immune synapses formed between cytotoxic T lymphocytes (cyan) and tumor cells (magenta) within a population of cultured cells. Cytotoxic granules are shown in yellow.30See Shi et al.31Image: Yu Shi and Wesley Legant, University of North Carolina - Chapel Hill. Cover Design: Thomas Phillips.",B,MAC_Bench/Nature/Cover/NATURE METHODS/18_4.png,MAC_Bench/Nature/Cover/NATURE METHODS/18_4.png,vith,18_4.txt,MAC_Bench/Nature/Cover/NATURE METHODS/21_11.png,MAC_Bench/Nature/Cover/NATURE METHODS/21_11.png,groundtruth,21_11.txt,MAC_Bench/Nature/Cover/NATURE METHODS/15_7.png,MAC_Bench/Nature/Cover/NATURE METHODS/15_7.png,vitg,15_7.txt,MAC_Bench/Nature/Cover/NATURE METHODS/19_6.png,MAC_Bench/Nature/Cover/NATURE METHODS/19_6.png,clip,19_6.txt,train32Nature Sustainability,7_10,Which of the following options best describe the cover story?,"Sustainable space33We are rapidly expanding our reach into Earth’s orbital space and beyond. The adverse impacts of this development occur right here on Earth’s surface and in our atmosphere, in our near orbital space and all the way to our ability to see into the stars. As we show in this month’s Focus, it is now urgent to extend our notions of protecting a sustainable future on Earth to ensure a sustainable future in space.34See Editorial35Credit: NASA/ESA/STScI. Cover Design: Alex Whitworth.",A,MAC_Bench/Nature/Cover/Nature Sustainability/7_10.png,MAC_Bench/Nature/Cover/Nature Sustainability/7_10.png,groundtruth,7_10.txt,MAC_Bench/Nature/Cover/Nature Sustainability/4_5.png,MAC_Bench/Nature/Cover/Nature Sustainability/4_5.png,clip,4_5.txt,MAC_Bench/Nature/Cover/Nature Sustainability/4_7.png,MAC_Bench/Nature/Cover/Nature Sustainability/4_7.png,vitg,4_7.txt,MAC_Bench/Nature/Cover/Nature Sustainability/6_12.png,MAC_Bench/Nature/Cover/Nature Sustainability/6_12.png,vith,6_12.txt,train36Nature Climate Change,14_4,Which of the following options best describe the cover story?,"Arctic erosion reduces ocean CO2 sink37Permafrost melting is linked to a number of reinforcing feedback processes accelerating warming. Writing in this issue, Nielsen and colleagues study how increased rates of Arctic coastal erosion, due to permafrost melt, affect Arctic Ocean biogeochemical cycling in an Earth system model. They find that greater terrestrial carbon input limits the amount of atmospheric carbon dioxide that the ocean can sequester, leading to amplified warming.38See Nielsen et al. and News & Views by Manizza39Image: Jenni Schurr and David M. Nielsen. Cover design: Debbie Maizels",A,MAC_Bench/Nature/Cover/Nature Climate Change/14_4.png,MAC_Bench/Nature/Cover/Nature Climate Change/14_4.png,groundtruth,14_4.txt,MAC_Bench/Nature/Cover/Nature Climate Change/11_1.png,MAC_Bench/Nature/Cover/Nature Climate Change/11_1.png,vitg,11_1.txt,MAC_Bench/Nature/Cover/Nature Climate Change/13_3.png,MAC_Bench/Nature/Cover/Nature Climate Change/13_3.png,vith,13_3.txt,MAC_Bench/Nature/Cover/Nature Climate Change/14_9.png,MAC_Bench/Nature/Cover/Nature Climate Change/14_9.png,clip,14_9.txt,train40The Journal of Physical Chemistry C,2025_6,Which of the following options best describe the cover story?,"In this perspective, we discuss how one can correlate computational catalysis results with experimental techniques, such as calorimetry, temperature-programmed desorption, infrared spectroscopy, and XPS measurements. For example, configuration space mapping for the alloying of Ru into Fe(100) through a lattice gas model enables the construction of coverage-dependent microkinetic models involving oxygenated aromatics and identifies a catalytically relevant ground state structure. This structure features Fe (gold spheres) alloyed with Ru at the surface (pink spheres) and Ru at subsurface sites (large red spheres). The lattice gas model accounts for 2-body and 3-body interactions (examples shown), as well as higher-order interactions, which are quantified using first-principles calculations. The lateral interactions between oxygenated aromatics can also be quantified within a mean-field model, allowing for the correlation with core-level binding energy shifts observed in XPS measurements. View the article.",A,MAC_Bench/ACS/Cover/The Journal of Physical Chemistry C/2025_6.png,MAC_Bench/ACS/Cover/The Journal of Physical Chemistry C/2025_6.png,groundtruth,2025_6.txt,MAC_Bench/ACS/Cover/The Journal of Physical Chemistry C/2023_3.png,MAC_Bench/ACS/Cover/The Journal of Physical Chemistry C/2023_3.png,clip,2023_3.txt,MAC_Bench/ACS/Cover/The Journal of Physical Chemistry C/2022_50.png,MAC_Bench/ACS/Cover/The Journal of Physical Chemistry C/2022_50.png,ave_2,2022_50.txt,MAC_Bench/ACS/Cover/The Journal of Physical Chemistry C/2024_37.png,MAC_Bench/ACS/Cover/The Journal of Physical Chemistry C/2024_37.png,vitg,2024_37.txt,val41ACS Applied Bio Materials,2024_3,Which of the following options best describe the cover story?,"Esterase-responsive turn-on fluorogenic prodrug of the marketed drug epalrestat was developed towards the treatment of cancer by selectively inhibiting aldose reductases. Activation of the prodrug by intracellular esterases, overexpressed in cancer cells, enables the real-time monitoring of the active drug release (epalrestat) with fluorescence readout.",D,MAC_Bench/ACS/Cover/ACS Applied Bio Materials/2024_6.png,MAC_Bench/ACS/Cover/ACS Applied Bio Materials/2024_6.png,vith,2024_6.txt,MAC_Bench/ACS/Cover/ACS Applied Bio Materials/2020_6.png,MAC_Bench/ACS/Cover/ACS Applied Bio Materials/2020_6.png,vitg,2020_6.txt,MAC_Bench/ACS/Cover/ACS Applied Bio Materials/2020_5.png,MAC_Bench/ACS/Cover/ACS Applied Bio Materials/2020_5.png,clip,2020_5.txt,MAC_Bench/ACS/Cover/ACS Applied Bio Materials/2024_3.png,MAC_Bench/ACS/Cover/ACS Applied Bio Materials/2024_3.png,groundtruth,2024_3.txt,train42Molecular Cell,85_4,Which of the following options best describe the cover story?,"On the cover: RNA modifications decorate RNA molecules, changing their physico-chemical43properties. Ribosomal RNAs (rRNAs) are heavily modified, with more than 200 modified44sites annotated in human rRNAs. In this issue of Molecular Cell, Milenkovic et al. systematically survey the rRNA modification patterns in development, differentiation,45and disease, finding that they represent epitranscriptomic fingerprints of their cells46and tissues of origin. These fingerprints can be used to predict developmental stages,47tissues, cell types, and cancer from as few as 250 reads. Cover artwork by Queralt48Tolosa (https://www.queralttolosa.com).",B,MAC_Bench/Cell/Cover/Molecular Cell/85_3.png,MAC_Bench/Cell/Cover/Molecular Cell/85_3.png,ave_1,85_3.txt,MAC_Bench/Cell/Cover/Molecular Cell/85_4.png,MAC_Bench/Cell/Cover/Molecular Cell/85_4.png,groundtruth,85_4.txt,MAC_Bench/Cell/Cover/Molecular Cell/85_1.png,MAC_Bench/Cell/Cover/Molecular Cell/85_1.png,clip,85_1.txt,MAC_Bench/Cell/Cover/Molecular Cell/82_25.png,MAC_Bench/Cell/Cover/Molecular Cell/82_25.png,ave_3,82_25.txt,train49Nature Reviews Rheumatology,20_7,Which of the following options best describe the cover story?,"Inspired by the Review on p323.50Cover design: Steven Hall",C,MAC_Bench/Nature/Cover/Nature Reviews Rheumatology/20_8.png,MAC_Bench/Nature/Cover/Nature Reviews Rheumatology/20_8.png,clip,20_8.txt,MAC_Bench/Nature/Cover/Nature Reviews Rheumatology/20_11.png,MAC_Bench/Nature/Cover/Nature Reviews Rheumatology/20_11.png,ave_1,20_11.txt,MAC_Bench/Nature/Cover/Nature Reviews Rheumatology/20_7.png,MAC_Bench/Nature/Cover/Nature Reviews Rheumatology/20_7.png,groundtruth,20_7.txt,MAC_Bench/Nature/Cover/Nature Reviews Rheumatology/19_6.png,MAC_Bench/Nature/Cover/Nature Reviews Rheumatology/19_6.png,vith,19_6.txt,train51Nature Catalysis,7_12,Which of the following options best describe the cover story?,"Reconstructing copper52In their work, Raffaella Buonsanti and colleagues investigate the mechanism of reconstruction of copper CO2 reduction electrocatalysts. Spectroscopic methods support a dissolution-redeposition mechanism involving solution-based Cu(I) species which are further elucidated as copper carbonyl and oxalate complexes using density functional theory.53See Vavra et al.54Cover design: Alex Whitworth.",D,MAC_Bench/Nature/Cover/Nature Catalysis/4_5.png,MAC_Bench/Nature/Cover/Nature Catalysis/4_5.png,vitg,4_5.txt,MAC_Bench/Nature/Cover/Nature Catalysis/4_12.png,MAC_Bench/Nature/Cover/Nature Catalysis/4_12.png,clip,4_12.txt,MAC_Bench/Nature/Cover/Nature Catalysis/5_8.png,MAC_Bench/Nature/Cover/Nature Catalysis/5_8.png,vith,5_8.txt,MAC_Bench/Nature/Cover/Nature Catalysis/7_12.png,MAC_Bench/Nature/Cover/Nature Catalysis/7_12.png,groundtruth,7_12.txt,val55Chemical Research in Toxicology,2024_6,Which of the following options best describe the cover story?,Insights from toxicology. View the article.,C,MAC_Bench/ACS/Cover/Chemical Research in Toxicology/2020_9.png,MAC_Bench/ACS/Cover/Chemical Research in Toxicology/2020_9.png,vith,2020_9.txt,MAC_Bench/ACS/Cover/Chemical Research in Toxicology/2020_2.png,MAC_Bench/ACS/Cover/Chemical Research in Toxicology/2020_2.png,vitg,2020_2.txt,MAC_Bench/ACS/Cover/Chemical Research in Toxicology/2024_6.png,MAC_Bench/ACS/Cover/Chemical Research in Toxicology/2024_6.png,groundtruth,2024_6.txt,MAC_Bench/ACS/Cover/Chemical Research in Toxicology/2016_7.png,MAC_Bench/ACS/Cover/Chemical Research in Toxicology/2016_7.png,clip,2016_7.txt,train56Inorganic Chemistry,2025_7,Which of the following options best describe the cover story?,"Co-encapsulating ligands can facilitate tunable chemistry by bringing metals together. This cover, depicting a racing circuit, conveys the excitement of clocking both ligand and metal performance. As the associated paper shows, in this chemical race, acyclic ligands and trivalent cations are high performers. The cover was prepared with Adobe Illustrator and MidJourney.",A,MAC_Bench/ACS/Cover/Inorganic Chemistry/2025_7.png,MAC_Bench/ACS/Cover/Inorganic Chemistry/2025_7.png,groundtruth,2025_7.txt,MAC_Bench/ACS/Cover/Inorganic Chemistry/2025_5.png,MAC_Bench/ACS/Cover/Inorganic Chemistry/2025_5.png,clip,2025_5.txt,MAC_Bench/ACS/Cover/Inorganic Chemistry/2023_10.png,MAC_Bench/ACS/Cover/Inorganic Chemistry/2023_10.png,vitg,2023_10.txt,MAC_Bench/ACS/Cover/Inorganic Chemistry/2024_31.png,MAC_Bench/ACS/Cover/Inorganic Chemistry/2024_31.png,vith,2024_31.txt,train57ACS Macro Letters,2024_7,Which of the following options best describe the cover story?,"The cover art demonstrates the helix-forming thin films, which have the ability to emit strong circularly polarized luminescence (indicating iCPL behavior) and to absorb specific circularly polarized light (also indicating iCPL behavior).",B,MAC_Bench/ACS/Cover/ACS Macro Letters/2019_10.png,MAC_Bench/ACS/Cover/ACS Macro Letters/2019_10.png,vith,2019_10.txt,MAC_Bench/ACS/Cover/ACS Macro Letters/2024_7.png,MAC_Bench/ACS/Cover/ACS Macro Letters/2024_7.png,groundtruth,2024_7.txt,MAC_Bench/ACS/Cover/ACS Macro Letters/2024_8.png,MAC_Bench/ACS/Cover/ACS Macro Letters/2024_8.png,clip,2024_8.txt,MAC_Bench/ACS/Cover/ACS Macro Letters/2023_4.png,MAC_Bench/ACS/Cover/ACS Macro Letters/2023_4.png,vitg,2023_4.txt,train58Nature Microbiology,9_7,Which of the following options best describe the cover story?,"Outcomes of personalized phage therapy59This image shows a bacteriophage on its bacterial host injecting its genome inside the cell where it will reproduce. New bacteriophages burst through the cell wall to find new hosts to infect. In nature, bacteriophages control bacterial populations. Today, they hold potential as a tool in the fight against antimicrobial resistance. A retrospective, observational study reports the efficacy of personalized phage therapy, especially when combined with antibiotics.60See Pirnay et al.61Image: TUMEGGY/SCIENCE PHOTO LIBRARY. Cover design: Debbie Maizels",B,MAC_Bench/Nature/Cover/Nature Microbiology/5_5.png,MAC_Bench/Nature/Cover/Nature Microbiology/5_5.png,clip,5_5.txt,MAC_Bench/Nature/Cover/Nature Microbiology/9_7.png,MAC_Bench/Nature/Cover/Nature Microbiology/9_7.png,groundtruth,9_7.txt,MAC_Bench/Nature/Cover/Nature Microbiology/6_10.png,MAC_Bench/Nature/Cover/Nature Microbiology/6_10.png,vith,6_10.txt,MAC_Bench/Nature/Cover/Nature Microbiology/7_12.png,MAC_Bench/Nature/Cover/Nature Microbiology/7_12.png,vitg,7_12.txt,train62Nature Water,2_4,Which of the following options best describe the cover story?,"The state of women in the water domain63While women are underrepresented in the formal water workforce, especially in low- and middle-income countries, they are highly overrepresented in the unpaid work of managing water, sanitation and hygiene (WASH) resources at the household level. The study by Caruso et al. examines whether women’s central role in household WASH has been exploited by WASH research and intervention activities. Reviewing previous WASH studies, they found the majority of interventions to be either gender-unequal or gender-unaware, and that many had relied entirely on participation by female household members for programme success. The authors discuss the risk of taking women’s time and work for granted and how it risks cementing gender inequalities in the water domain.64See Caruso, B. A. et al.65Image: Hugh Sitton / Photodisc / Getty Images. Cover design: Debbie Maizels",D,MAC_Bench/Nature/Cover/Nature Water/1_11.png,MAC_Bench/Nature/Cover/Nature Water/1_11.png,clip,1_11.txt,MAC_Bench/Nature/Cover/Nature Water/1_12.png,MAC_Bench/Nature/Cover/Nature Water/1_12.png,ave_2,1_12.txt,MAC_Bench/Nature/Cover/Nature Water/2_2.png,MAC_Bench/Nature/Cover/Nature Water/2_2.png,vitg,2_2.txt,MAC_Bench/Nature/Cover/Nature Water/2_4.png,MAC_Bench/Nature/Cover/Nature Water/2_4.png,groundtruth,2_4.txt,train66CELL RESEARCH,34_7,Which of the following options best describe the cover story?,"A Nian beast (proinflammatory PD-1+ T cells) wreaks havoc in the village (a metaphor for atherosclerosis, AS) on New Year's Eve. A man, dressed in red, ignites firecrackers (FcgR-binding anti-PD-1 mAb), preventing the Nian beast from causing trouble in the village (the shrinkage of AS plaques). See page 407–427 by Lin Fan et al. for details.",A,MAC_Bench/Nature/Cover/CELL RESEARCH/34_7.png,MAC_Bench/Nature/Cover/CELL RESEARCH/34_7.png,groundtruth,34_7.txt,MAC_Bench/Nature/Cover/CELL RESEARCH/31_3.png,MAC_Bench/Nature/Cover/CELL RESEARCH/31_3.png,clip,31_3.txt,MAC_Bench/Nature/Cover/CELL RESEARCH/33_6.png,MAC_Bench/Nature/Cover/CELL RESEARCH/33_6.png,ave_2,33_6.txt,MAC_Bench/Nature/Cover/CELL RESEARCH/34_5.png,MAC_Bench/Nature/Cover/CELL RESEARCH/34_5.png,ave_3,34_5.txt,val67Trends in Cancer,10_12,Which of the following options best describe the cover story?,"The Swiss cheese model was originally proposed to show how hazards68can pass through system defense failures or ‘holes within the cheese.’ In this issue,69Teran et al. use the Swiss cheese model to frame how tumor-promoting mechanisms70promote the development, maintenance, and progression of glioblastoma by finding71‘holes’ in multilayered homeostatic defenses. Image designed by Ashley Durand and72reprinted with permission, Cleveland Clinic Foundation.",B,MAC_Bench/Cell/Cover/Trends in Cancer/10_9.png,MAC_Bench/Cell/Cover/Trends in Cancer/10_9.png,vitg,10_9.txt,MAC_Bench/Cell/Cover/Trends in Cancer/10_12.png,MAC_Bench/Cell/Cover/Trends in Cancer/10_12.png,groundtruth,10_12.txt,MAC_Bench/Cell/Cover/Trends in Cancer/10_6.png,MAC_Bench/Cell/Cover/Trends in Cancer/10_6.png,clip,10_6.txt,MAC_Bench/Cell/Cover/Trends in Cancer/8_11.png,MAC_Bench/Cell/Cover/Trends in Cancer/8_11.png,vith,8_11.txt,train73Nature Electronics,7_3,Which of the following options best describe the cover story?,"Two-dimensional devices stack up74Graphene chemisensors and molybdenum disulfide memtransistors can be vertically stacked using a monolithic integration process to create near-sensor computing chips. The false-colour scanning electron microscopy image on the cover shows a two-tier cell containing two graphene chemitransistors located above two molybdenum disulfide memtransistors.75See Ghosh et al. and News & Views by Han et al.76Image: Saptarshi Das, Subir Ghosh, The Pennsylvania State University. Cover design: Lauren Heslop",C,MAC_Bench/Nature/Cover/Nature Electronics/7_4.png,MAC_Bench/Nature/Cover/Nature Electronics/7_4.png,ave_3,7_4.txt,MAC_Bench/Nature/Cover/Nature Electronics/4_7.png,MAC_Bench/Nature/Cover/Nature Electronics/4_7.png,clip,4_7.txt,MAC_Bench/Nature/Cover/Nature Electronics/7_3.png,MAC_Bench/Nature/Cover/Nature Electronics/7_3.png,groundtruth,7_3.txt,MAC_Bench/Nature/Cover/Nature Electronics/6_4.png,MAC_Bench/Nature/Cover/Nature Electronics/6_4.png,ave_2,6_4.txt,train77Science Advances,11_6,Which of the following options best describe the cover story?,ONLINE COVER The reaction of Arabidopsis seedling skin when simultaneously exposed to a stomata-increasing small molecule and a peptide that triggers immune response. Green represents the nucleus of a cell that has the potential to become a stoma; magenta indicates the cell periphery. Herrmann and Sepuru et al. discovered that the activation of immune signaling can cross-regulate the otherwise highly specific stomatal development signaling if the availability of the shared downstream components becomes suboptimal. Images were taken with a confocal microscope. Credit: Arvid Herrmann,D,MAC_Bench/Science/Cover/Science Advances/10_1.png,MAC_Bench/Science/Cover/Science Advances/10_1.png,clip,10_1.txt,MAC_Bench/Science/Cover/Science Advances/10_8.png,MAC_Bench/Science/Cover/Science Advances/10_8.png,vitg,10_8.txt,MAC_Bench/Science/Cover/Science Advances/9_30.png,MAC_Bench/Science/Cover/Science Advances/9_30.png,vith,9_30.txt,MAC_Bench/Science/Cover/Science Advances/11_6.png,MAC_Bench/Science/Cover/Science Advances/11_6.png,groundtruth,11_6.txt,train78Nature Reviews Cardiology,21_6,Which of the following options best describe the cover story?,"Immune checkpoints, inspired by the Review on p443.79Cover design: Vicky Summersby",B,MAC_Bench/Nature/Cover/Nature Reviews Cardiology/21_5.png,MAC_Bench/Nature/Cover/Nature Reviews Cardiology/21_5.png,vitg,21_5.txt,MAC_Bench/Nature/Cover/Nature Reviews Cardiology/21_6.png,MAC_Bench/Nature/Cover/Nature Reviews Cardiology/21_6.png,groundtruth,21_6.txt,MAC_Bench/Nature/Cover/Nature Reviews Cardiology/21_12.png,MAC_Bench/Nature/Cover/Nature Reviews Cardiology/21_12.png,clip,21_12.txt,MAC_Bench/Nature/Cover/Nature Reviews Cardiology/20_1.png,MAC_Bench/Nature/Cover/Nature Reviews Cardiology/20_1.png,vith,20_1.txt,train80Acta Pharmacologica Sinica,45_4,Which of the following options best describe the cover story?,"Cover Credit: Methionine-choline deficient diet (MCD) has been widely illustrated in inducing persistent alterations of gut microbiota and metabolome during hepatitis. Given the close interaction between gut and liver disorders, this study further highlights that intake of MCD predisposes to experimental colitis and enhances its pathogenesis via modulating gut microbes and macrophages. (Doi: 10.1038/s41401-024-01291-y). See the article in pages 1912-1925.",D,MAC_Bench/Nature/Cover/Acta Pharmacologica Sinica/44_5.png,MAC_Bench/Nature/Cover/Acta Pharmacologica Sinica/44_5.png,clip,44_5.txt,MAC_Bench/Nature/Cover/Acta Pharmacologica Sinica/43_5.png,MAC_Bench/Nature/Cover/Acta Pharmacologica Sinica/43_5.png,ave_3,43_5.txt,MAC_Bench/Nature/Cover/Acta Pharmacologica Sinica/42_6.png,MAC_Bench/Nature/Cover/Acta Pharmacologica Sinica/42_6.png,vith,42_6.txt,MAC_Bench/Nature/Cover/Acta Pharmacologica Sinica/45_4.png,MAC_Bench/Nature/Cover/Acta Pharmacologica Sinica/45_4.png,groundtruth,45_4.txt,train81NATURE REVIEWS GENETICS,25_7,Which of the following options best describe the cover story?,"Inspired by the Review on p38182Cover design: Patrick Morgan",A,MAC_Bench/Nature/Cover/NATURE REVIEWS GENETICS/25_7.png,MAC_Bench/Nature/Cover/NATURE REVIEWS GENETICS/25_7.png,groundtruth,25_7.txt,MAC_Bench/Nature/Cover/NATURE REVIEWS GENETICS/26_2.png,MAC_Bench/Nature/Cover/NATURE REVIEWS GENETICS/26_2.png,ave_3,26_2.txt,MAC_Bench/Nature/Cover/NATURE REVIEWS GENETICS/25_8.png,MAC_Bench/Nature/Cover/NATURE REVIEWS GENETICS/25_8.png,vitg,25_8.txt,MAC_Bench/Nature/Cover/NATURE REVIEWS GENETICS/25_3.png,MAC_Bench/Nature/Cover/NATURE REVIEWS GENETICS/25_3.png,clip,25_3.txt,train83Journal of Proteome Research,2024_6,Which of the following options best describe the cover story?,"A California sea lion swimming in the surf at Pacifica, California. Domoic acid toxicosis is a major affliction for sea lions in California. Photo credit: Pádraig Duignan.",B,MAC_Bench/ACS/Cover/Journal of Proteome Research/2011_11.png,MAC_Bench/ACS/Cover/Journal of Proteome Research/2011_11.png,ave_3,2011_11.txt,MAC_Bench/ACS/Cover/Journal of Proteome Research/2024_6.png,MAC_Bench/ACS/Cover/Journal of Proteome Research/2024_6.png,groundtruth,2024_6.txt,MAC_Bench/ACS/Cover/Journal of Proteome Research/2023_1.png,MAC_Bench/ACS/Cover/Journal of Proteome Research/2023_1.png,vith,2023_1.txt,MAC_Bench/ACS/Cover/Journal of Proteome Research/2016_11.png,MAC_Bench/ACS/Cover/Journal of Proteome Research/2016_11.png,clip,2016_11.txt,train84Industrial & Engineering Chemistry Research,2024_34,Which of the following options best describe the cover story?,This work presents grafting of a CuCo alloy bimetallic nanoparticle over g-C3N4 for photocatalytic degradation of pharmaceutical contaminant ibuprofen and H2 gas evolution by water splitting.,A,MAC_Bench/ACS/Cover/Industrial & Engineering Chemistry Research/2024_34.png,MAC_Bench/ACS/Cover/Industrial & Engineering Chemistry Research/2024_34.png,groundtruth,2024_34.txt,MAC_Bench/ACS/Cover/Industrial & Engineering Chemistry Research/2024_15.png,MAC_Bench/ACS/Cover/Industrial & Engineering Chemistry Research/2024_15.png,vith,2024_15.txt,MAC_Bench/ACS/Cover/Industrial & Engineering Chemistry Research/2024_27.png,MAC_Bench/ACS/Cover/Industrial & Engineering Chemistry Research/2024_27.png,clip,2024_27.txt,MAC_Bench/ACS/Cover/Industrial & Engineering Chemistry Research/2022_21.png,MAC_Bench/ACS/Cover/Industrial & Engineering Chemistry Research/2022_21.png,ave_1,2022_21.txt,test85Trends in Genetics,40_7,Which of the following options best describe the cover story?,"The neuronal composition that makes up our brains is relatively stable86from shortly after birth to adulthood. However, these post-mitotic neurons continue87to88undergo property changes throughout the lifespan. In this issue, Gabrielle Prince,89Molly90Reynolds, Verdion Martina, and HaoSheng Sun describe recent characterizations of the91functional and molecular changes that neurons undergo across postnatal development92and discuss cell-intrinsic versus cell-extrinsic mechanisms in the regulation of neuronal93maturation. Illustration by Dalton Patterson, Sharrell Greene, and Gabrielle Prince.",C,MAC_Bench/Cell/Cover/Trends in Genetics/37_10.png,MAC_Bench/Cell/Cover/Trends in Genetics/37_10.png,vitg,37_10.txt,MAC_Bench/Cell/Cover/Trends in Genetics/37_8.png,MAC_Bench/Cell/Cover/Trends in Genetics/37_8.png,ave_2,37_8.txt,MAC_Bench/Cell/Cover/Trends in Genetics/40_7.png,MAC_Bench/Cell/Cover/Trends in Genetics/40_7.png,groundtruth,40_7.txt,MAC_Bench/Cell/Cover/Trends in Genetics/37_9.png,MAC_Bench/Cell/Cover/Trends in Genetics/37_9.png,clip,37_9.txt,test94Nature Reviews Bioengineering,2_7,Which of the following options best describe the cover story?,"High-throughput microfluidic 3D cell culture systems can be designed with different biological complexity, cell sources and cell configurations to model aspects of human tissues and organs. Such microfluidic systems can thereby serve as non-clinical testing tools for drug development. See Jihoon Ko et al.95Cover design: Simon Bradbrook",B,MAC_Bench/Nature/Cover/Nature Reviews Bioengineering/2_10.png,MAC_Bench/Nature/Cover/Nature Reviews Bioengineering/2_10.png,clip,2_10.txt,MAC_Bench/Nature/Cover/Nature Reviews Bioengineering/2_7.png,MAC_Bench/Nature/Cover/Nature Reviews Bioengineering/2_7.png,groundtruth,2_7.txt,MAC_Bench/Nature/Cover/Nature Reviews Bioengineering/1_6.png,MAC_Bench/Nature/Cover/Nature Reviews Bioengineering/1_6.png,vitg,1_6.txt,MAC_Bench/Nature/Cover/Nature Reviews Bioengineering/1_8.png,MAC_Bench/Nature/Cover/Nature Reviews Bioengineering/1_8.png,ave_3,1_8.txt,train96Crystal Growth & Design,2024_17,Which of the following options best describe the cover story?,The Cr-doped large single-crystal diamond was synthesized under a high pressure and high temperature. The addition of Cr reduces the nitrogen content in the diamond. A low nitrogen synthesis environment is more conducive to the doping of Cr atoms into the diamond lattice. The Cr atom exists in the diamond in the form of Cr,D,MAC_Bench/ACS/Cover/Crystal Growth & Design/2023_6.png,MAC_Bench/ACS/Cover/Crystal Growth & Design/2023_6.png,vitg,2023_6.txt,MAC_Bench/ACS/Cover/Crystal Growth & Design/2023_9.png,MAC_Bench/ACS/Cover/Crystal Growth & Design/2023_9.png,clip,2023_9.txt,MAC_Bench/ACS/Cover/Crystal Growth & Design/2018_1.png,MAC_Bench/ACS/Cover/Crystal Growth & Design/2018_1.png,ave_2,2018_1.txt,MAC_Bench/ACS/Cover/Crystal Growth & Design/2024_17.png,MAC_Bench/ACS/Cover/Crystal Growth & Design/2024_17.png,groundtruth,2024_17.txt,train97ACS Macro Letters,2024_5,Which of the following options best describe the cover story?,"The introduction of crown ether at the terminus marks a novel and effective strategy to not only elevate message readability, but also to increase the information storage capacity of digital polymers, leveraging a simple and classical property of crown ether since its discovery by a great chemist, Charles Pedersen, in 1967.",C,MAC_Bench/ACS/Cover/ACS Macro Letters/2017_5.png,MAC_Bench/ACS/Cover/ACS Macro Letters/2017_5.png,vitg,2017_5.txt,MAC_Bench/ACS/Cover/ACS Macro Letters/2023_6.png,MAC_Bench/ACS/Cover/ACS Macro Letters/2023_6.png,vith,2023_6.txt,MAC_Bench/ACS/Cover/ACS Macro Letters/2024_5.png,MAC_Bench/ACS/Cover/ACS Macro Letters/2024_5.png,groundtruth,2024_5.txt,MAC_Bench/ACS/Cover/ACS Macro Letters/2024_7.png,MAC_Bench/ACS/Cover/ACS Macro Letters/2024_7.png,clip,2024_7.txt,train98Nature Catalysis,7_4,Which of the following options best describe the cover story?,"Dispersion control99In their work, L. Robert Baker and colleagues investigate the effects of molecular dispersion of a heterogenized cobalt phthalocyanine on the rate and product selectivity in electrocatalytic CO2 reduction.100See Zhu et al.101Image: Elad Gross and Hadar Shema, Hebrew University, Jerusalem. Cover design: Alex Whitworth.",B,MAC_Bench/Nature/Cover/Nature Catalysis/3_11.png,MAC_Bench/Nature/Cover/Nature Catalysis/3_11.png,clip,3_11.txt,MAC_Bench/Nature/Cover/Nature Catalysis/7_4.png,MAC_Bench/Nature/Cover/Nature Catalysis/7_4.png,groundtruth,7_4.txt,MAC_Bench/Nature/Cover/Nature Catalysis/5_9.png,MAC_Bench/Nature/Cover/Nature Catalysis/5_9.png,ave_3,5_9.txt,MAC_Bench/Nature/Cover/Nature Catalysis/3_7.png,MAC_Bench/Nature/Cover/Nature Catalysis/3_7.png,vitg,3_7.txt,test102Nature Cancer,5_1,Which of the following options best describe the cover story?,"2024 in Review103This month we present a dedicated issue, Focus on 2024 in Review, that includes news, analysis and comment pieces on the most exciting advances and biggest challenges of the past year, together with a selection of the primary research articles published in Nature Cancer and elsewhere over the past 12 months.104See our December Editorial and associated Focus content.105Image: Ernie Janes / Alamy Stock Photo. Cover design: Allen Beattie",C,MAC_Bench/Nature/Cover/Nature Cancer/2_1.png,MAC_Bench/Nature/Cover/Nature Cancer/2_1.png,vitg,2_1.txt,MAC_Bench/Nature/Cover/Nature Cancer/5_8.png,MAC_Bench/Nature/Cover/Nature Cancer/5_8.png,ave_2,5_8.txt,MAC_Bench/Nature/Cover/Nature Cancer/5_1.png,MAC_Bench/Nature/Cover/Nature Cancer/5_1.png,groundtruth,5_1.txt,MAC_Bench/Nature/Cover/Nature Cancer/4_1.png,MAC_Bench/Nature/Cover/Nature Cancer/4_1.png,clip,4_1.txt,train106ACS Sensors,2025_1,Which of the following options best describe the cover story?,This cover and Collection celebrate 10 years of ACS Sensors. View the Editorial.,D,MAC_Bench/ACS/Cover/ACS Sensors/2016_12.png,MAC_Bench/ACS/Cover/ACS Sensors/2016_12.png,ave_2,2016_12.txt,MAC_Bench/ACS/Cover/ACS Sensors/2021_12.png,MAC_Bench/ACS/Cover/ACS Sensors/2021_12.png,clip,2021_12.txt,MAC_Bench/ACS/Cover/ACS Sensors/2018_4.png,MAC_Bench/ACS/Cover/ACS Sensors/2018_4.png,ave_3,2018_4.txt,MAC_Bench/ACS/Cover/ACS Sensors/2025_1.png,MAC_Bench/ACS/Cover/ACS Sensors/2025_1.png,groundtruth,2025_1.txt,test107Nature Computational Science,4_9,Which of the following options best describe the cover story?,"Predicting the impact of wildfires108In recent years, the frequency and intensity of wildfires have increased due to the effects of climate change. To date, many established wildfire policies have been ineffective, and alternative approaches are therefore needed in order to reduce the damage caused by such wildfire events. In this issue, Hussam Mahmoud suggests that future wildfire models should take inspiration from epidemic network modeling to predict the damage to individual buildings, as well as to improve our understanding of the impact of different mitigation strategies on the community as a whole.109See Mahmoud110Image: Nitat Termmee / Moment / Getty Images. Cover design: Alex Wing",A,MAC_Bench/Nature/Cover/Nature Computational Science/4_9.png,MAC_Bench/Nature/Cover/Nature Computational Science/4_9.png,groundtruth,4_9.txt,MAC_Bench/Nature/Cover/Nature Computational Science/4_6.png,MAC_Bench/Nature/Cover/Nature Computational Science/4_6.png,ave_3,4_6.txt,MAC_Bench/Nature/Cover/Nature Computational Science/4_3.png,MAC_Bench/Nature/Cover/Nature Computational Science/4_3.png,clip,4_3.txt,MAC_Bench/Nature/Cover/Nature Computational Science/1_2.png,MAC_Bench/Nature/Cover/Nature Computational Science/1_2.png,vith,1_2.txt,train111NATURE MATERIALS,23_10,Which of the following options best describe the cover story?,"Growing tunable moirés112Two-dimensional structures with tunable moiré patterns, which display tunable interlayer excitons and moiré intralayer excitons, are achieved by epitaxial bottom-up growth.113See Fortin-Deschênes et al.114Image: Yihao Song and Matthieu Fortin-Deschênes, Yale University. Cover design: Alex Whitworth",A,MAC_Bench/Nature/Cover/NATURE MATERIALS/23_10.png,MAC_Bench/Nature/Cover/NATURE MATERIALS/23_10.png,groundtruth,23_10.txt,MAC_Bench/Nature/Cover/NATURE MATERIALS/23_4.png,MAC_Bench/Nature/Cover/NATURE MATERIALS/23_4.png,vitg,23_4.txt,MAC_Bench/Nature/Cover/NATURE MATERIALS/22_9.png,MAC_Bench/Nature/Cover/NATURE MATERIALS/22_9.png,clip,22_9.txt,MAC_Bench/Nature/Cover/NATURE MATERIALS/20_5.png,MAC_Bench/Nature/Cover/NATURE MATERIALS/20_5.png,ave_3,20_5.txt,train115Trends in Chemistry,6_13,Which of the following options best describe the cover story?,"The upcoming micro-optics revolution has been set to transform how we116create optical devices for various industries. To date, scientists mostly focus on117organic/118inorganic photoresins for 3D printing, allowing us to print structures whose scale119lies120beyond our eyesight. In their Forum article, Winczewski and co-authors highlight the121need to develop cutting-edge photoresins for 3D printing that transform into functional122glass/ceramics upon heat exposure. Innovation at the forefront is crucial to paving123the way for crafting unique multi-material optical components with spatially dissimilar124compositions. Cover Image Credit: Ella Maruschenko - Ella Maru Studio",B,MAC_Bench/Cell/Cover/Trends in Chemistry/5_4.png,MAC_Bench/Cell/Cover/Trends in Chemistry/5_4.png,vitg,5_4.txt,MAC_Bench/Cell/Cover/Trends in Chemistry/6_13.png,MAC_Bench/Cell/Cover/Trends in Chemistry/6_13.png,groundtruth,6_13.txt,MAC_Bench/Cell/Cover/Trends in Chemistry/3_8.png,MAC_Bench/Cell/Cover/Trends in Chemistry/3_8.png,vith,3_8.txt,MAC_Bench/Cell/Cover/Trends in Chemistry/4_4.png,MAC_Bench/Cell/Cover/Trends in Chemistry/4_4.png,clip,4_4.txt,train125Nature Metabolism,6_1,Which of the following options best describe the cover story?,"Inuit genetic variants1264% of the Inuit population from snowy Greenland (pictured) are homozygous for a specific TBC1D4 loss-of-function variant, which leads to skeletal muscle insulin resistance but allows for a normal metabolic response to exercise.127See Kristensen, J. M., Kjøbsted, R. et al.128Image: Wirestock, Inc. / Alamy Stock Photo. Cover Design: Thomas Phillips.",C,MAC_Bench/Nature/Cover/Nature Metabolism/5_5.png,MAC_Bench/Nature/Cover/Nature Metabolism/5_5.png,vitg,5_5.txt,MAC_Bench/Nature/Cover/Nature Metabolism/6_3.png,MAC_Bench/Nature/Cover/Nature Metabolism/6_3.png,vith,6_3.txt,MAC_Bench/Nature/Cover/Nature Metabolism/6_1.png,MAC_Bench/Nature/Cover/Nature Metabolism/6_1.png,groundtruth,6_1.txt,MAC_Bench/Nature/Cover/Nature Metabolism/6_2.png,MAC_Bench/Nature/Cover/Nature Metabolism/6_2.png,clip,6_2.txt,train129Nature Computational Science,5_1,Which of the following options best describe the cover story?,"Energy-efficient large language models130Implementing artificial intelligence (AI) models, such as large language models (LLMs), on conventional von Neumann computing hardware — which separates memory and computing — is notoriously energy and power intensive. In this issue, Abu Sebastian and colleagues demonstrate that devices based on non-volatile memory (a type of analog in-memory computing hardware), constructed in three dimensions (3D), could substantially improve the energy efficiency of LLMs by leveraging ‘mixture of experts’ (MoEs) models. The cover image depicts MoEs neural networks realized through 3D analog in-memory computing on a silicon microchip, with multiple stacked tiers representing the experts in the network.131See Büchel et al. and Anand Subramoney132Image: Jeongung Cho, CUBE3D Graphic. Cover design: Alex Wing.",B,MAC_Bench/Nature/Cover/Nature Computational Science/3_9.png,MAC_Bench/Nature/Cover/Nature Computational Science/3_9.png,vitg,3_9.txt,MAC_Bench/Nature/Cover/Nature Computational Science/5_1.png,MAC_Bench/Nature/Cover/Nature Computational Science/5_1.png,groundtruth,5_1.txt,MAC_Bench/Nature/Cover/Nature Computational Science/1_2.png,MAC_Bench/Nature/Cover/Nature Computational Science/1_2.png,clip,1_2.txt,MAC_Bench/Nature/Cover/Nature Computational Science/4_3.png,MAC_Bench/Nature/Cover/Nature Computational Science/4_3.png,ave_2,4_3.txt,train133Trends in Cancer,10_10,Which of the following options best describe the cover story?,"Many therapeutic strategies that are positive in preclinical mice134experiments fail in human clinical trials due to biological differences between mice135and humans. In this issue, Joshi et al. propose using pigs as alternative animals for136preclinical testing due to their many similarities shared with humans. In particular,137the138Oncopig model is likely to play a key role in developing novel cancer therapeutics.139Cover image courtesy of gettyimages/Danielle D. Hughson.",B,MAC_Bench/Cell/Cover/Trends in Cancer/7_13.png,MAC_Bench/Cell/Cover/Trends in Cancer/7_13.png,vith,7_13.txt,MAC_Bench/Cell/Cover/Trends in Cancer/10_10.png,MAC_Bench/Cell/Cover/Trends in Cancer/10_10.png,groundtruth,10_10.txt,MAC_Bench/Cell/Cover/Trends in Cancer/10_7.png,MAC_Bench/Cell/Cover/Trends in Cancer/10_7.png,vitg,10_7.txt,MAC_Bench/Cell/Cover/Trends in Cancer/9_8.png,MAC_Bench/Cell/Cover/Trends in Cancer/9_8.png,clip,9_8.txt,train140Trends in Endocrinology & Metabolism,35_7,Which of the following options best describe the cover story?,"From the need for better preclinical models of disease to the use of new141technologies that can recapitulate the complexity of living systems, our approach142in143studying metabolic diseases is constantly being refined. This month, we focus on the144issue of modeling metabolism: our authors reflect on novel methodological approaches145in the study of endocrine and metabolic disorders and provide new frameworks to146address some of the current questions in diabetes, obesity, liver disease, cancer147metabolism and host-microbiome homeostasis. Our cover depicts this variety of148perspectives as building blocks of different colors and sizes that together contribute149a more comprehensive model of metabolism. Artwork credit: modified from Jobalou/150Getty Images.",A,MAC_Bench/Cell/Cover/Trends in Endocrinology & Metabolism/35_7.png,MAC_Bench/Cell/Cover/Trends in Endocrinology & Metabolism/35_7.png,groundtruth,35_7.txt,MAC_Bench/Cell/Cover/Trends in Endocrinology & Metabolism/35_9.png,MAC_Bench/Cell/Cover/Trends in Endocrinology & Metabolism/35_9.png,ave_3,35_9.txt,MAC_Bench/Cell/Cover/Trends in Endocrinology & Metabolism/35_2.png,MAC_Bench/Cell/Cover/Trends in Endocrinology & Metabolism/35_2.png,clip,35_2.txt,MAC_Bench/Cell/Cover/Trends in Endocrinology & Metabolism/34_4.png,MAC_Bench/Cell/Cover/Trends in Endocrinology & Metabolism/34_4.png,vitg,34_4.txt,train151ACS Applied Engineering Materials,2024_10,Which of the following options best describe the cover story?,"Deep eutectic solvent/surfactant functionalized titanium dioxide (TiO2) coated graphene oxide (GO) can be a sensitive, ultrafast (within 3 min), and sustainable adsorbent for the complete removal of hazardous textile dye from industrial effluent.",A,MAC_Bench/ACS/Cover/ACS Applied Engineering Materials/2024_10.png,MAC_Bench/ACS/Cover/ACS Applied Engineering Materials/2024_10.png,groundtruth,2024_10.txt,MAC_Bench/ACS/Cover/ACS Applied Engineering Materials/2023_11.png,MAC_Bench/ACS/Cover/ACS Applied Engineering Materials/2023_11.png,vitg,2023_11.txt,MAC_Bench/ACS/Cover/ACS Applied Engineering Materials/2023_10.png,MAC_Bench/ACS/Cover/ACS Applied Engineering Materials/2023_10.png,clip,2023_10.txt,MAC_Bench/ACS/Cover/ACS Applied Engineering Materials/2023_8.png,MAC_Bench/ACS/Cover/ACS Applied Engineering Materials/2023_8.png,ave_3,2023_8.txt,train152Journal of Medicinal Chemistry,2024_1,Which of the following options best describe the cover story?,"-A2B-corroles for photodynamic therapy of lung cancer. The lead photosensitizers showed remarkable properties, with IC50 values below 100 nM and no cytotoxicity per se, properties resulting from a synergy between the macrocyclic system and the hydrazone moiety.",C,MAC_Bench/ACS/Cover/Journal of Medicinal Chemistry/2009_19.png,MAC_Bench/ACS/Cover/Journal of Medicinal Chemistry/2009_19.png,clip,2009_19.txt,MAC_Bench/ACS/Cover/Journal of Medicinal Chemistry/2024_7.png,MAC_Bench/ACS/Cover/Journal of Medicinal Chemistry/2024_7.png,vitg,2024_7.txt,MAC_Bench/ACS/Cover/Journal of Medicinal Chemistry/2024_1.png,MAC_Bench/ACS/Cover/Journal of Medicinal Chemistry/2024_1.png,groundtruth,2024_1.txt,MAC_Bench/ACS/Cover/Journal of Medicinal Chemistry/2023_4.png,MAC_Bench/ACS/Cover/Journal of Medicinal Chemistry/2023_4.png,vith,2023_4.txt,val153Analytical Chemistry,2025_7,Which of the following options best describe the cover story?,"The inclusive droplet digital ELISA (iddELISA) expands the boundaries of digital immunoassays by incorporating all types of bead encapsulations into the analysis, enhancing assay efficiency, and simplifying operations. This innovative approach holds great promise for the early detection of low-abundance biomarkers.",A,MAC_Bench/ACS/Cover/Analytical Chemistry/2025_7.png,MAC_Bench/ACS/Cover/Analytical Chemistry/2025_7.png,groundtruth,2025_7.txt,MAC_Bench/ACS/Cover/Analytical Chemistry/2021_28.png,MAC_Bench/ACS/Cover/Analytical Chemistry/2021_28.png,vith,2021_28.txt,MAC_Bench/ACS/Cover/Analytical Chemistry/2024_8.png,MAC_Bench/ACS/Cover/Analytical Chemistry/2024_8.png,vitg,2024_8.txt,MAC_Bench/ACS/Cover/Analytical Chemistry/2016_6.png,MAC_Bench/ACS/Cover/Analytical Chemistry/2016_6.png,clip,2016_6.txt,train154The Journal of Organic Chemistry,2025_6,Which of the following options best describe the cover story?,"In an industrial setting, toluene oxidation products such as benzoic acid, benzaldehyde, and benzoate esters are crucial fine chemicals. Chemists are dedicated to preparing high-value chemical materials through green and simple oxidation technologies. This cover illustrates an aryl-halides-initiated photocatalytic strategy for the green and selective oxidation of toluene.",D,MAC_Bench/ACS/Cover/The Journal of Organic Chemistry/2013_20.png,MAC_Bench/ACS/Cover/The Journal of Organic Chemistry/2013_20.png,clip,2013_20.txt,MAC_Bench/ACS/Cover/The Journal of Organic Chemistry/2021_7.png,MAC_Bench/ACS/Cover/The Journal of Organic Chemistry/2021_7.png,vitg,2021_7.txt,MAC_Bench/ACS/Cover/The Journal of Organic Chemistry/2019_20.png,MAC_Bench/ACS/Cover/The Journal of Organic Chemistry/2019_20.png,vith,2019_20.txt,MAC_Bench/ACS/Cover/The Journal of Organic Chemistry/2025_6.png,MAC_Bench/ACS/Cover/The Journal of Organic Chemistry/2025_6.png,groundtruth,2025_6.txt,val155Nature Reviews Endocrinology,21_1,Which of the following options best describe the cover story?,"Mapping progress in cell replacement therapies for T1DM, inspired by the Review on p14.156Cover design: Edward Byrne",D,MAC_Bench/Nature/Cover/Nature Reviews Endocrinology/21_2.png,MAC_Bench/Nature/Cover/Nature Reviews Endocrinology/21_2.png,clip,21_2.txt,MAC_Bench/Nature/Cover/Nature Reviews Endocrinology/19_1.png,MAC_Bench/Nature/Cover/Nature Reviews Endocrinology/19_1.png,ave_3,19_1.txt,MAC_Bench/Nature/Cover/Nature Reviews Endocrinology/20_1.png,MAC_Bench/Nature/Cover/Nature Reviews Endocrinology/20_1.png,ave_2,20_1.txt,MAC_Bench/Nature/Cover/Nature Reviews Endocrinology/21_1.png,MAC_Bench/Nature/Cover/Nature Reviews Endocrinology/21_1.png,groundtruth,21_1.txt,train157Journal of the American Chemical Society,2024_39,Which of the following options best describe the cover story?,Measurement of single-molecule conductance has emerged as a promising tool to unravel complex chemistry at the nanoscale. Single-molecule conductance and Flicker noise analysis can be employed to probe chemical reactions at the single-molecule level,C,MAC_Bench/ACS/Cover/Journal of the American Chemical Society/2019_14.png,MAC_Bench/ACS/Cover/Journal of the American Chemical Society/2019_14.png,ave_3,2019_14.txt,MAC_Bench/ACS/Cover/Journal of the American Chemical Society/2016_18.png,MAC_Bench/ACS/Cover/Journal of the American Chemical Society/2016_18.png,vith,2016_18.txt,MAC_Bench/ACS/Cover/Journal of the American Chemical Society/2024_39.png,MAC_Bench/ACS/Cover/Journal of the American Chemical Society/2024_39.png,groundtruth,2024_39.txt,MAC_Bench/ACS/Cover/Journal of the American Chemical Society/2021_37.png,MAC_Bench/ACS/Cover/Journal of the American Chemical Society/2021_37.png,clip,2021_37.txt,train158Nature Metabolism,7_1,Which of the following options best describe the cover story?,"Multifaceted myokines159Two concurrent studies highlight the dual role of feimin, a feeding-induced myokine, in regulating glucose homeostasis as well as physical performance during exercise. The image depicts staining of fibre types in the soleus muscle.160See Shi, X., Hu, X., Fang, X. et al. and Peng, Y., Jia, L. et al.161Image: Ying Peng. Cover Design: Thomas Phillips.",D,MAC_Bench/Nature/Cover/Nature Metabolism/2_7.png,MAC_Bench/Nature/Cover/Nature Metabolism/2_7.png,vitg,2_7.txt,MAC_Bench/Nature/Cover/Nature Metabolism/3_11.png,MAC_Bench/Nature/Cover/Nature Metabolism/3_11.png,clip,3_11.txt,MAC_Bench/Nature/Cover/Nature Metabolism/6_11.png,MAC_Bench/Nature/Cover/Nature Metabolism/6_11.png,ave_3,6_11.txt,MAC_Bench/Nature/Cover/Nature Metabolism/7_1.png,MAC_Bench/Nature/Cover/Nature Metabolism/7_1.png,groundtruth,7_1.txt,train162Journal of Chemical Information and Modeling,2025_5,Which of the following options best describe the cover story?,"Extracting relevant structures from free energy molecular simulations can be a daunting task. The newly developed FESTA script simplifies this process, offering ease, robustness, and broad compatibility, making ""fishing"" in the free energy pond both efficient and enjoyable. View the article.",B,MAC_Bench/ACS/Cover/Journal of Chemical Information and Modeling/2025_4.png,MAC_Bench/ACS/Cover/Journal of Chemical Information and Modeling/2025_4.png,clip,2025_4.txt,MAC_Bench/ACS/Cover/Journal of Chemical Information and Modeling/2025_5.png,MAC_Bench/ACS/Cover/Journal of Chemical Information and Modeling/2025_5.png,groundtruth,2025_5.txt,MAC_Bench/ACS/Cover/Journal of Chemical Information and Modeling/2023_22.png,MAC_Bench/ACS/Cover/Journal of Chemical Information and Modeling/2023_22.png,ave_3,2023_22.txt,MAC_Bench/ACS/Cover/Journal of Chemical Information and Modeling/2025_3.png,MAC_Bench/ACS/Cover/Journal of Chemical Information and Modeling/2025_3.png,ave_2,2025_3.txt,train163Nature Cell Biology,26_4,Which of the following options best describe the cover story?,"Focus on cell death164The cover shows 3-colour live imaging in vivo demonstrating a role for ferroptosis-like cell death in triggering macrophage recruitment but delaying the resolution of inflammation during wounding in Drosophila. See Focus for more content. Focus165See Davidson et al.166Image: Andrew J. Davidson, University of Glasgow. Cover design: Lauren Heslop",C,MAC_Bench/Nature/Cover/Nature Cell Biology/24_11.png,MAC_Bench/Nature/Cover/Nature Cell Biology/24_11.png,ave_1,24_11.txt,MAC_Bench/Nature/Cover/Nature Cell Biology/23_1.png,MAC_Bench/Nature/Cover/Nature Cell Biology/23_1.png,clip,23_1.txt,MAC_Bench/Nature/Cover/Nature Cell Biology/26_4.png,MAC_Bench/Nature/Cover/Nature Cell Biology/26_4.png,groundtruth,26_4.txt,MAC_Bench/Nature/Cover/Nature Cell Biology/24_4.png,MAC_Bench/Nature/Cover/Nature Cell Biology/24_4.png,vitg,24_4.txt,train167Acta Pharmacologica Sinica,45_8,Which of the following options best describe the cover story?,"Cover Credit: Following MIR, MCMECs release GMCSF to recruit monocyte infiltration, which in turn releases CCL2 to induce CCR2+ immune cell infiltration. GMCSF transits CCR2+ macrophages to M1 phenotype, mediating and amplifying inflammation that exacerbates MIR injury, while CCL2 transits CCR2+ macrophages to M2 phenotype, mediating fibrotic remodeling after MIR.",C,MAC_Bench/Nature/Cover/Acta Pharmacologica Sinica/42_10.png,MAC_Bench/Nature/Cover/Acta Pharmacologica Sinica/42_10.png,vitg,42_10.txt,MAC_Bench/Nature/Cover/Acta Pharmacologica Sinica/46_1.png,MAC_Bench/Nature/Cover/Acta Pharmacologica Sinica/46_1.png,vith,46_1.txt,MAC_Bench/Nature/Cover/Acta Pharmacologica Sinica/45_8.png,MAC_Bench/Nature/Cover/Acta Pharmacologica Sinica/45_8.png,groundtruth,45_8.txt,MAC_Bench/Nature/Cover/Acta Pharmacologica Sinica/43_7.png,MAC_Bench/Nature/Cover/Acta Pharmacologica Sinica/43_7.png,clip,43_7.txt,val168Journal of Agricultural and Food Chemistry,2025_2,Which of the following options best describe the cover story?,"This cover highlights the use of nitrogen-fixing bacteria in crops, emphasizing that, through genetic modification, these bacteria can provide crops with an increased source of nitrogen. It depicts a scene of a green wheat field adjacent to a patch of yellow soil. Within the wheat field, a plant is illustrated with red lines extending from its roots into the soil, symbolizing the process of nutrient absorption. The text ""NH4+"" on the image further underscores the focus on nitrogen, emphasizing the role of nitrogen-fixing bacteria in enhancing crop nutrition through genetic engineering. Additionally, it is worth noting that the partial elements of this cover were created using an Artificial Intelligence-based image generation tool named ""Doubao"".",D,MAC_Bench/ACS/Cover/Journal of Agricultural and Food Chemistry/2025_6.png,MAC_Bench/ACS/Cover/Journal of Agricultural and Food Chemistry/2025_6.png,vith,2025_6.txt,MAC_Bench/ACS/Cover/Journal of Agricultural and Food Chemistry/2022_25.png,MAC_Bench/ACS/Cover/Journal of Agricultural and Food Chemistry/2022_25.png,vitg,2022_25.txt,MAC_Bench/ACS/Cover/Journal of Agricultural and Food Chemistry/2022_2.png,MAC_Bench/ACS/Cover/Journal of Agricultural and Food Chemistry/2022_2.png,clip,2022_2.txt,MAC_Bench/ACS/Cover/Journal of Agricultural and Food Chemistry/2025_2.png,MAC_Bench/ACS/Cover/Journal of Agricultural and Food Chemistry/2025_2.png,groundtruth,2025_2.txt,test169Nature Reviews Earth & Environment,6_1,Which of the following options best describe the cover story?,"Understanding of the Sumatran subduction zone and its hazards has increased since the 2004 Indian Ocean earthquake and tsunami. This Review commemorates the 20th anniversary of this event by outlining these insights and how they can inform future strategies to improve tsunami preparedness.170Jon Bower / Alamy Stock Photo. Cover design: Carl Conway.",B,MAC_Bench/Nature/Cover/Nature Reviews Earth & Environment/5_4.png,MAC_Bench/Nature/Cover/Nature Reviews Earth & Environment/5_4.png,clip,5_4.txt,MAC_Bench/Nature/Cover/Nature Reviews Earth & Environment/6_1.png,MAC_Bench/Nature/Cover/Nature Reviews Earth & Environment/6_1.png,groundtruth,6_1.txt,MAC_Bench/Nature/Cover/Nature Reviews Earth & Environment/5_10.png,MAC_Bench/Nature/Cover/Nature Reviews Earth & Environment/5_10.png,ave_3,5_10.txt,MAC_Bench/Nature/Cover/Nature Reviews Earth & Environment/4_12.png,MAC_Bench/Nature/Cover/Nature Reviews Earth & Environment/4_12.png,vitg,4_12.txt,train171Environmental Science & Technology,2025_3,Which of the following options best describe the cover story?,"This study reveals that allergen-harboring extracellular vesicles (EVs) derived from allergenic species are widespread in the environment. EVs enhance allergen stability and translocation. It suggests a novel vesicle-mediated pathway for allergen dissemination and implications for human health. Background elements of the city, greenery, and houses in the cover art were generated by the image generation function of ChatGPT 4.0.",C,MAC_Bench/ACS/Cover/Environmental Science & Technology/2022_23.png,MAC_Bench/ACS/Cover/Environmental Science & Technology/2022_23.png,ave_2,2022_23.txt,MAC_Bench/ACS/Cover/Environmental Science & Technology/2024_24.png,MAC_Bench/ACS/Cover/Environmental Science & Technology/2024_24.png,clip,2024_24.txt,MAC_Bench/ACS/Cover/Environmental Science & Technology/2025_3.png,MAC_Bench/ACS/Cover/Environmental Science & Technology/2025_3.png,groundtruth,2025_3.txt,MAC_Bench/ACS/Cover/Environmental Science & Technology/2016_19.png,MAC_Bench/ACS/Cover/Environmental Science & Technology/2016_19.png,vith,2016_19.txt,train172Trends in Microbiology,32_12,Which of the following options best describe the cover story?,"The design of the cover image is based on Newton's cradle, which173is demonstrative of the conservation of momentum and energy. It is essential to174understand how microbes interact, assemble, and persist within microbial communities.175In the context of abundant and diverse commensal microbes in the host, enterococci,176as depicted as the lifted and released ball, drive the proliferation, pathogenicity177or178persistence of representative pathogens such as S. aureus, C. difficile and E. coli via metabolic cross-feeding, upregulation of virulence and biofilm formation, thus179influencing the progression of bacterial infections and affecting treatment options.180This181driving role of enterococci in polymicrobial infections is the subject of the review182by Xu183and colleagues. Image courtesy: Kui Zhu and Wenjiao Xu",C,MAC_Bench/Cell/Cover/Trends in Microbiology/33_1.png,MAC_Bench/Cell/Cover/Trends in Microbiology/33_1.png,vith,33_1.txt,MAC_Bench/Cell/Cover/Trends in Microbiology/32_6.png,MAC_Bench/Cell/Cover/Trends in Microbiology/32_6.png,clip,32_6.txt,MAC_Bench/Cell/Cover/Trends in Microbiology/32_12.png,MAC_Bench/Cell/Cover/Trends in Microbiology/32_12.png,groundtruth,32_12.txt,MAC_Bench/Cell/Cover/Trends in Microbiology/32_5.png,MAC_Bench/Cell/Cover/Trends in Microbiology/32_5.png,vitg,32_5.txt,train184Precision Chemistry,2024_5,Which of the following options best describe the cover story?,"This cover art for the Special Issue “Precision Chemistry for Two-Dimensional Materials” was designed by Xiangfeng Duan of the University of California, Los Angeles and coworkers. It illustrates CuxBi2Se3 nanoplates with systematically tunable Cu doping concentrations, doping sites, and electronic properties as a potential material for future electronics.",C,MAC_Bench/ACS/Cover/Precision Chemistry/2023_6.png,MAC_Bench/ACS/Cover/Precision Chemistry/2023_6.png,ave_2,2023_6.txt,MAC_Bench/ACS/Cover/Precision Chemistry/2024_6.png,MAC_Bench/ACS/Cover/Precision Chemistry/2024_6.png,clip,2024_6.txt,MAC_Bench/ACS/Cover/Precision Chemistry/2024_5.png,MAC_Bench/ACS/Cover/Precision Chemistry/2024_5.png,groundtruth,2024_5.txt,MAC_Bench/ACS/Cover/Precision Chemistry/2024_3.png,MAC_Bench/ACS/Cover/Precision Chemistry/2024_3.png,ave_3,2024_3.txt,val185Nature Reviews Nephrology,20_9,Which of the following options best describe the cover story?,"The varied roles of non-haematopoietic cells, inspired by the Review on p206.186Cover design: Lara Crow",D,MAC_Bench/Nature/Cover/Nature Reviews Nephrology/19_9.png,MAC_Bench/Nature/Cover/Nature Reviews Nephrology/19_9.png,vith,19_9.txt,MAC_Bench/Nature/Cover/Nature Reviews Nephrology/20_8.png,MAC_Bench/Nature/Cover/Nature Reviews Nephrology/20_8.png,clip,20_8.txt,MAC_Bench/Nature/Cover/Nature Reviews Nephrology/20_3.png,MAC_Bench/Nature/Cover/Nature Reviews Nephrology/20_3.png,vitg,20_3.txt,MAC_Bench/Nature/Cover/Nature Reviews Nephrology/20_9.png,MAC_Bench/Nature/Cover/Nature Reviews Nephrology/20_9.png,groundtruth,20_9.txt,train187Nature Computational Science,4_7,Which of the following options best describe the cover story?,"Machine learning with nonlinear optical neural networks188Photonic computing offers many advantages over traditional digital computing, such as high parallelism and low energy consumption, yet current development has been mostly limited to linear operations. In this issue, Hao Wang et al. introduce a large-scale nonlinear photonic neural system based on disordered polycrystalline materials. The system generates both linear and nonlinear optical speckle features, forming a complex neural network that can be used for computing tasks. The authors demonstrate that this nonlinear system provides advantages over linear optical systems for various machine learning tasks, including image classification, regression, and graph classification. The cover image depicts the neural network formed by light scattering through a disordered medium.189See Hao Wang et al. and Tianyu Wang190Image: Hao Wang, Ecole Normale Supérieure and Tsinghua University. Cover design: Alex Wing",C,MAC_Bench/Nature/Cover/Nature Computational Science/4_3.png,MAC_Bench/Nature/Cover/Nature Computational Science/4_3.png,clip,4_3.txt,MAC_Bench/Nature/Cover/Nature Computational Science/3_9.png,MAC_Bench/Nature/Cover/Nature Computational Science/3_9.png,vitg,3_9.txt,MAC_Bench/Nature/Cover/Nature Computational Science/4_7.png,MAC_Bench/Nature/Cover/Nature Computational Science/4_7.png,groundtruth,4_7.txt,MAC_Bench/Nature/Cover/Nature Computational Science/4_6.png,MAC_Bench/Nature/Cover/Nature Computational Science/4_6.png,ave_1,4_6.txt,train191Cell Metabolism,36_10,Which of the following options best describe the cover story?,"On the cover: Stress has a profound impact on gut disorders. In this issue of Cell Metabolism, Wei et al. reveal that psychological stress enriches gut microbial metabolite indole-3-acetate,192which disrupts intestinal stem cell differentiation and triggers epithelial injury.193The depiction of rolling clouds and stirring stars, inspired by Van Gogh’s masterpiece194The Starry Night, represents restless emotions in a person with depression. The broken ground and195castle along the winding river illustrate injured intestinal epithelia. The involvement196of microbes and the metabolite is represented as ants on the broken door. Cover art197by Xiao Zheng and Haiping Hao.",A,MAC_Bench/Cell/Cover/Cell Metabolism/36_10.png,MAC_Bench/Cell/Cover/Cell Metabolism/36_10.png,groundtruth,36_10.txt,MAC_Bench/Cell/Cover/Cell Metabolism/37_2.png,MAC_Bench/Cell/Cover/Cell Metabolism/37_2.png,vitg,37_2.txt,MAC_Bench/Cell/Cover/Cell Metabolism/36_2.png,MAC_Bench/Cell/Cover/Cell Metabolism/36_2.png,clip,36_2.txt,MAC_Bench/Cell/Cover/Cell Metabolism/37_1.png,MAC_Bench/Cell/Cover/Cell Metabolism/37_1.png,ave_2,37_1.txt,val198Trends in Immunology,45_8,Which of the following options best describe the cover story?,"Sarcoidosis is an immunological disease characterized by the presence199of coalescing, tightly clustered, non-necrotizing granulomas. On pages 406–418, Robert200and colleagues discuss the dysregulated immune responses that may lead to granuloma201formation and maintenance; they propose the novel hypothesis that maladaptive innate202immune training may help drive sarcoidosis pathogenesis. Inspired by Mayan calendar203stones, the image alludes to different immune cells and elements present in a granuloma,204which is a key pathophysiological feature of sarcoidosis. Image credit: Bertsy Goic205drawinscience.fr.",A,MAC_Bench/Cell/Cover/Trends in Immunology/45_8.png,MAC_Bench/Cell/Cover/Trends in Immunology/45_8.png,groundtruth,45_8.txt,MAC_Bench/Cell/Cover/Trends in Immunology/44_5.png,MAC_Bench/Cell/Cover/Trends in Immunology/44_5.png,vitg,44_5.txt,MAC_Bench/Cell/Cover/Trends in Immunology/45_10.png,MAC_Bench/Cell/Cover/Trends in Immunology/45_10.png,vith,45_10.txt,MAC_Bench/Cell/Cover/Trends in Immunology/40_1.png,MAC_Bench/Cell/Cover/Trends in Immunology/40_1.png,clip,40_1.txt,train206Nature Sustainability,8_1,Which of the following options best describe the cover story?,"Sustainable rice farming in South Asia207The overuse of nitrogen fertilizer in the production of rice can have detrimental environmental effects. With a large dataset from more than 31,000 farmer fields in South Asia, Coggins and colleagues identify pathways optimizing nitrogen use efficiency in rice cropping systems across the region.208See Coggins et al.209Image: Arunabh Bhattacharjee / Alamy Stock. Cover design: Alex Whitworth",B,MAC_Bench/Nature/Cover/Nature Sustainability/7_3.png,MAC_Bench/Nature/Cover/Nature Sustainability/7_3.png,ave_1,7_3.txt,MAC_Bench/Nature/Cover/Nature Sustainability/8_1.png,MAC_Bench/Nature/Cover/Nature Sustainability/8_1.png,groundtruth,8_1.txt,MAC_Bench/Nature/Cover/Nature Sustainability/5_1.png,MAC_Bench/Nature/Cover/Nature Sustainability/5_1.png,vitg,5_1.txt,MAC_Bench/Nature/Cover/Nature Sustainability/4_2.png,MAC_Bench/Nature/Cover/Nature Sustainability/4_2.png,clip,4_2.txt,train210CELL RESEARCH,34_2,Which of the following options best describe the cover story?,"Beneath the blazing sun, the guardian deity of agriculture wields the sacred sickle-shaped tool, TMS5, which removes cP from the cP-ΔCCA-tRNAs accumulated in rice, thereby safeguarding its fertility. In contrast, the rice left beyond his reach, burdened with cP-ΔCCA-tRNAs, remains sterile. See page 763–775 by Bin Yan et al. for details.",B,MAC_Bench/Nature/Cover/CELL RESEARCH/32_1.png,MAC_Bench/Nature/Cover/CELL RESEARCH/32_1.png,vith,32_1.txt,MAC_Bench/Nature/Cover/CELL RESEARCH/34_2.png,MAC_Bench/Nature/Cover/CELL RESEARCH/34_2.png,groundtruth,34_2.txt,MAC_Bench/Nature/Cover/CELL RESEARCH/34_10.png,MAC_Bench/Nature/Cover/CELL RESEARCH/34_10.png,vitg,34_10.txt,MAC_Bench/Nature/Cover/CELL RESEARCH/34_4.png,MAC_Bench/Nature/Cover/CELL RESEARCH/34_4.png,clip,34_4.txt,train211Nature Chemical Biology,20_4,Which of the following options best describe the cover story?,"Specificity for cathepsin S212The structure of non-natural peptide inhibitors can be rapidly optimized to specifically block the activity of protease targets. The cover image depicts different non-natural peptides bound to the molecular structure of cathepsin S, representing a few possible outcomes of site saturation mutagenesis screening.213See Petruzzella et al.214Image: Aaron Petruzzella, EPFL. Cover design: Alex Wing",A,MAC_Bench/Nature/Cover/Nature Chemical Biology/20_4.png,MAC_Bench/Nature/Cover/Nature Chemical Biology/20_4.png,groundtruth,20_4.txt,MAC_Bench/Nature/Cover/Nature Chemical Biology/18_10.png,MAC_Bench/Nature/Cover/Nature Chemical Biology/18_10.png,clip,18_10.txt,MAC_Bench/Nature/Cover/Nature Chemical Biology/19_10.png,MAC_Bench/Nature/Cover/Nature Chemical Biology/19_10.png,vitg,19_10.txt,MAC_Bench/Nature/Cover/Nature Chemical Biology/20_5.png,MAC_Bench/Nature/Cover/Nature Chemical Biology/20_5.png,ave_3,20_5.txt,train215ACS Catalysis,2024_16,Which of the following options best describe the cover story?,The debut of cyclic alkyl amino carbene on the gold nanoparticle surface leads to the selective reduction of CO2 to CO.,C,MAC_Bench/ACS/Cover/ACS Catalysis/2021_19.png,MAC_Bench/ACS/Cover/ACS Catalysis/2021_19.png,clip,2021_19.txt,MAC_Bench/ACS/Cover/ACS Catalysis/2020_19.png,MAC_Bench/ACS/Cover/ACS Catalysis/2020_19.png,vitg,2020_19.txt,MAC_Bench/ACS/Cover/ACS Catalysis/2024_16.png,MAC_Bench/ACS/Cover/ACS Catalysis/2024_16.png,groundtruth,2024_16.txt,MAC_Bench/ACS/Cover/ACS Catalysis/2022_15.png,MAC_Bench/ACS/Cover/ACS Catalysis/2022_15.png,vith,2022_15.txt,train216Accounts of Chemical Research,2024_17,Which of the following options best describe the cover story?,"Buckminster Fuller's innovative concept, face-rotating polyhedra (FRP), involves individual faces rotating around central axes, creating distinctive facial patterns while preserving the polyhedral core. Drawing from this mathematical inspiration, our group has constructed numerous chiral molecular cages resembling the FRP structure, utilizing building blocks that showcase C/A and P/M rotational patterns.",A,MAC_Bench/ACS/Cover/Accounts of Chemical Research/2024_17.png,MAC_Bench/ACS/Cover/Accounts of Chemical Research/2024_17.png,groundtruth,2024_17.txt,MAC_Bench/ACS/Cover/Accounts of Chemical Research/2011_10.png,MAC_Bench/ACS/Cover/Accounts of Chemical Research/2011_10.png,ave_2,2011_10.txt,MAC_Bench/ACS/Cover/Accounts of Chemical Research/2019_5.png,MAC_Bench/ACS/Cover/Accounts of Chemical Research/2019_5.png,vitg,2019_5.txt,MAC_Bench/ACS/Cover/Accounts of Chemical Research/2014_11.png,MAC_Bench/ACS/Cover/Accounts of Chemical Research/2014_11.png,clip,2014_11.txt,val217Nature Chemistry,16_10,Which of the following options best describe the cover story?,"Caught in a trap218Sulfate-binding proteins — which capture sulfate from water using hydrogen bonds from charge-neutral motifs — serve as key inspiration in anion receptor chemistry, but synthetic systems showing similar selectivity have so far been elusive. Xin Wu, Evelyne Deplazes and colleagues have now made a neutral molecular cage that binds sulfate in water using 12 hydrogen atoms, as depicted artistically on the cover. The background shows an empty cage and an unbound sulfate.219See Jing et al.220Image: Bolun Chen, Senling Culture Co., Ltd. Cover Design: Tulsi Voralia",C,MAC_Bench/Nature/Cover/Nature Chemistry/13_7.png,MAC_Bench/Nature/Cover/Nature Chemistry/13_7.png,ave_2,13_7.txt,MAC_Bench/Nature/Cover/Nature Chemistry/15_5.png,MAC_Bench/Nature/Cover/Nature Chemistry/15_5.png,clip,15_5.txt,MAC_Bench/Nature/Cover/Nature Chemistry/16_10.png,MAC_Bench/Nature/Cover/Nature Chemistry/16_10.png,groundtruth,16_10.txt,MAC_Bench/Nature/Cover/Nature Chemistry/13_3.png,MAC_Bench/Nature/Cover/Nature Chemistry/13_3.png,ave_3,13_3.txt,train221Organic Letters,2025_2,Which of the following options best describe the cover story?,"As the Lunar New Year in the Year of the Snake approached, we developed a method for the addition of Grignard reagents to pillar[4]arene[1]benzoquinone monoxime, enabling the functionalization of pillar[4]arene derivatives. This evoked imagery of the snake, sleek, slithering, and symbolic of intuition, transformation, and growth in Chinese culture, bringing good fortune to the chemists who orchestrated this magical transformation from substrate to diverse products.",C,MAC_Bench/ACS/Cover/Organic Letters/2023_47.png,MAC_Bench/ACS/Cover/Organic Letters/2023_47.png,clip,2023_47.txt,MAC_Bench/ACS/Cover/Organic Letters/2022_4.png,MAC_Bench/ACS/Cover/Organic Letters/2022_4.png,vith,2022_4.txt,MAC_Bench/ACS/Cover/Organic Letters/2025_2.png,MAC_Bench/ACS/Cover/Organic Letters/2025_2.png,groundtruth,2025_2.txt,MAC_Bench/ACS/Cover/Organic Letters/2025_1.png,MAC_Bench/ACS/Cover/Organic Letters/2025_1.png,vitg,2025_1.txt,train222Trends in Cancer,10_7,Which of the following options best describe the cover story?,"An immune rich microenvironment correlates with improved outcomes223for patients with breast cancer and response to chemotherapies, forming the rationale224for T cell-based immunotherapies in the treatment of some forms of breast cancer.225In this issue, Rayson et al. review the composition of the immune infiltrates in breast226cancer and discuss its pertinent role in identifying biomarkers for immune checkpoint227blockade and for effective combination therapy strategies. The cover represents a228tumor microenvironment (garden) filled with a variety of immune cell types (flower229variety) that contribute to the tumor’s growth or suppression. Image courtesy of230gettyimages/Pobytov.",B,MAC_Bench/Cell/Cover/Trends in Cancer/10_3.png,MAC_Bench/Cell/Cover/Trends in Cancer/10_3.png,ave_2,10_3.txt,MAC_Bench/Cell/Cover/Trends in Cancer/10_7.png,MAC_Bench/Cell/Cover/Trends in Cancer/10_7.png,groundtruth,10_7.txt,MAC_Bench/Cell/Cover/Trends in Cancer/10_9.png,MAC_Bench/Cell/Cover/Trends in Cancer/10_9.png,vitg,10_9.txt,MAC_Bench/Cell/Cover/Trends in Cancer/10_1.png,MAC_Bench/Cell/Cover/Trends in Cancer/10_1.png,clip,10_1.txt,train231Med,5_4,Which of the following options best describe the cover story?,"On the cover: Artificial intelligence (AI) has made significant strides in biomedical232research, showcasing its transformative potential in driving innovation within drug233development. In this issue of Med, Zhang et al. review the significant advancements in AI-assisted drug development, focusing on234small molecules, RNA, and antibodies. The review highlights the challenge in obtaining235approval for AI-conceived drugs and proposes leveraging large language models and236diffusion models as solutions. The cover image captures two AI robots analyzing AI-generated237drugs in a clinical environment, symbolizing AI's transformative impact on drug discovery,238development, and clinical trials.",A,MAC_Bench/Cell/Cover/Med/5_4.png,MAC_Bench/Cell/Cover/Med/5_4.png,groundtruth,5_4.txt,MAC_Bench/Cell/Cover/Med/5_10.png,MAC_Bench/Cell/Cover/Med/5_10.png,clip,5_10.txt,MAC_Bench/Cell/Cover/Med/4_1.png,MAC_Bench/Cell/Cover/Med/4_1.png,ave_2,4_1.txt,MAC_Bench/Cell/Cover/Med/5_7.png,MAC_Bench/Cell/Cover/Med/5_7.png,vitg,5_7.txt,test239Industrial & Engineering Chemistry Research,2024_25,Which of the following options best describe the cover story?,This study proposes a ranking framework by introducing Biochar Quality Index scores based on selected quality parameters and application thereof for adsorptive removal of antibiotic sulfamethoxazole from water matrices.,D,MAC_Bench/ACS/Cover/Industrial & Engineering Chemistry Research/2024_10.png,MAC_Bench/ACS/Cover/Industrial & Engineering Chemistry Research/2024_10.png,vith,2024_10.txt,MAC_Bench/ACS/Cover/Industrial & Engineering Chemistry Research/2021_24.png,MAC_Bench/ACS/Cover/Industrial & Engineering Chemistry Research/2021_24.png,vitg,2021_24.txt,MAC_Bench/ACS/Cover/Industrial & Engineering Chemistry Research/2024_20.png,MAC_Bench/ACS/Cover/Industrial & Engineering Chemistry Research/2024_20.png,clip,2024_20.txt,MAC_Bench/ACS/Cover/Industrial & Engineering Chemistry Research/2024_25.png,MAC_Bench/ACS/Cover/Industrial & Engineering Chemistry Research/2024_25.png,groundtruth,2024_25.txt,train240ACS ES&T Engineering,2024_6,Which of the following options best describe the cover story?,"Laser-induced graphene-based electroconductive membranes (ECMs) have the potential for electro-cleaning of the fouled membranes. Non-oxidative electro-cleaning effectively prolongs the ECM lifespan by avoiding damage, while catalytic oxidative cleaning offers superior flux recovery for severely fouled membranes, highlighting innovative strategies for enhancing ECM performance in membrane technology.",C,MAC_Bench/ACS/Cover/ACS ES&T Engineering/2023_10.png,MAC_Bench/ACS/Cover/ACS ES&T Engineering/2023_10.png,vith,2023_10.txt,MAC_Bench/ACS/Cover/ACS ES&T Engineering/2022_6.png,MAC_Bench/ACS/Cover/ACS ES&T Engineering/2022_6.png,clip,2022_6.txt,MAC_Bench/ACS/Cover/ACS ES&T Engineering/2024_6.png,MAC_Bench/ACS/Cover/ACS ES&T Engineering/2024_6.png,groundtruth,2024_6.txt,MAC_Bench/ACS/Cover/ACS ES&T Engineering/2022_5.png,MAC_Bench/ACS/Cover/ACS ES&T Engineering/2022_5.png,vitg,2022_5.txt,train241Cell Reports Methods,5_1,Which of the following options best describe the cover story?,"On the cover: The cover image illustrates MMoCHi, a supervised machine learning framework242for cell-type classification of multimodal, single-cell genomics and spatial profiling243data developed by Caron et al. The colored layers and corresponding cell drawings represent different modalities244(e.g., morphology, protein, mRNA), with the bottom row showing the final, classified245form. The images at the bottom are micrographs of lymph nodes, with the colored annotations246from MMoCHi on the right. Credit: Daniel P. Caron.",D,MAC_Bench/Cell/Cover/Cell Reports Methods/3_4.png,MAC_Bench/Cell/Cover/Cell Reports Methods/3_4.png,clip,3_4.txt,MAC_Bench/Cell/Cover/Cell Reports Methods/2_9.png,MAC_Bench/Cell/Cover/Cell Reports Methods/2_9.png,ave_2,2_9.txt,MAC_Bench/Cell/Cover/Cell Reports Methods/3_5.png,MAC_Bench/Cell/Cover/Cell Reports Methods/3_5.png,vitg,3_5.txt,MAC_Bench/Cell/Cover/Cell Reports Methods/5_1.png,MAC_Bench/Cell/Cover/Cell Reports Methods/5_1.png,groundtruth,5_1.txt,val247Industrial & Engineering Chemistry Research,2024_15,Which of the following options best describe the cover story?,"This cover art illustrates the molecular-level H2S scavenging process, assisted by water, using simple aldehydes and glyoxal. Effective H2S removal is crucial to the oil and gas industry due to its environmental hazards, occupational health risks and potential damage to industrial facilities. Cover art created using StockCake.",B,MAC_Bench/ACS/Cover/Industrial & Engineering Chemistry Research/2023_37.png,MAC_Bench/ACS/Cover/Industrial & Engineering Chemistry Research/2023_37.png,vith,2023_37.txt,MAC_Bench/ACS/Cover/Industrial & Engineering Chemistry Research/2024_15.png,MAC_Bench/ACS/Cover/Industrial & Engineering Chemistry Research/2024_15.png,groundtruth,2024_15.txt,MAC_Bench/ACS/Cover/Industrial & Engineering Chemistry Research/2021_14.png,MAC_Bench/ACS/Cover/Industrial & Engineering Chemistry Research/2021_14.png,vitg,2021_14.txt,MAC_Bench/ACS/Cover/Industrial & Engineering Chemistry Research/2022_21.png,MAC_Bench/ACS/Cover/Industrial & Engineering Chemistry Research/2022_21.png,clip,2022_21.txt,train248NATURE REVIEWS MICROBIOLOGY,22_9,Which of the following options best describe the cover story?,"Machine learning for microbiologists, inspired by the Review on p191.249Cover design: Philip Patenall.",D,MAC_Bench/Nature/Cover/NATURE REVIEWS MICROBIOLOGY/21_1.png,MAC_Bench/Nature/Cover/NATURE REVIEWS MICROBIOLOGY/21_1.png,clip,21_1.txt,MAC_Bench/Nature/Cover/NATURE REVIEWS MICROBIOLOGY/22_7.png,MAC_Bench/Nature/Cover/NATURE REVIEWS MICROBIOLOGY/22_7.png,vitg,22_7.txt,MAC_Bench/Nature/Cover/NATURE REVIEWS MICROBIOLOGY/22_8.png,MAC_Bench/Nature/Cover/NATURE REVIEWS MICROBIOLOGY/22_8.png,ave_2,22_8.txt,MAC_Bench/Nature/Cover/NATURE REVIEWS MICROBIOLOGY/22_9.png,MAC_Bench/Nature/Cover/NATURE REVIEWS MICROBIOLOGY/22_9.png,groundtruth,22_9.txt,val250BDJ In Practice,37_12,Which of the following options best describe the cover story?,"Volume 37 | Issue 1 | January251In this issue we forecast developments in four areas of dentistry, take a closer look at how a life coach is relevant to dentistry and delve into the detail of England's Long Term Workforce Plan252Cover illustration by Tim Marrs",D,MAC_Bench/Nature/Cover/BDJ In Practice/35_7.png,MAC_Bench/Nature/Cover/BDJ In Practice/35_7.png,clip,35_7.txt,MAC_Bench/Nature/Cover/BDJ In Practice/37_8.png,MAC_Bench/Nature/Cover/BDJ In Practice/37_8.png,ave_3,37_8.txt,MAC_Bench/Nature/Cover/BDJ In Practice/37_11.png,MAC_Bench/Nature/Cover/BDJ In Practice/37_11.png,vith,37_11.txt,MAC_Bench/Nature/Cover/BDJ In Practice/37_12.png,MAC_Bench/Nature/Cover/BDJ In Practice/37_12.png,groundtruth,37_12.txt,train253Nature Synthesis,3_12,Which of the following options best describe the cover story?,"MOFs made to order254The synthesis of isoreticular zeolite-like MOFs is achieved using a face-directed assembly strategy inspired by architecture techniques. The strategy combines a supermolecular building block approach with the use of various centring structure-directing agents.255See Barsukova et al.256Image: Aleksandr Sapianik. Cover design: Amie Fernandez",B,MAC_Bench/Nature/Cover/Nature Synthesis/2_3.png,MAC_Bench/Nature/Cover/Nature Synthesis/2_3.png,clip,2_3.txt,MAC_Bench/Nature/Cover/Nature Synthesis/3_12.png,MAC_Bench/Nature/Cover/Nature Synthesis/3_12.png,groundtruth,3_12.txt,MAC_Bench/Nature/Cover/Nature Synthesis/2_8.png,MAC_Bench/Nature/Cover/Nature Synthesis/2_8.png,vith,2_8.txt,MAC_Bench/Nature/Cover/Nature Synthesis/3_5.png,MAC_Bench/Nature/Cover/Nature Synthesis/3_5.png,vitg,3_5.txt,val257Science Immunology,9_100,Which of the following options best describe the cover story?,"ONLINE COVER Sex-Biased Gene Regulation in T Cells. In females, X chromosome inactivation (XCI) represses gene expression from one X chromosome to balance gene dosage between the sexes. This process is controlled by the long noncoding RNA Xist, which coats the inactive X chromosome and promotes epigenetic gene silencing. Forsyth et al. studied XCI in mouse and human T cells, a process that is much more dynamic in T cells than in most other somatic cells. NF-κB signaling downstream of the T cell receptor was required for the localization of Xist to the inactive X chromosome and the maintenance of XCI after T cell activation. This month’s cover illustration depicts Xist (orange) localizing to the inactive X chromosome on the right. Credit: Noelle Burgess/Science Immunology",B,MAC_Bench/Science/Cover/Science Immunology/8_87.png,MAC_Bench/Science/Cover/Science Immunology/8_87.png,clip,8_87.txt,MAC_Bench/Science/Cover/Science Immunology/9_100.png,MAC_Bench/Science/Cover/Science Immunology/9_100.png,groundtruth,9_100.txt,MAC_Bench/Science/Cover/Science Immunology/9_93.png,MAC_Bench/Science/Cover/Science Immunology/9_93.png,vitg,9_93.txt,MAC_Bench/Science/Cover/Science Immunology/3_19.png,MAC_Bench/Science/Cover/Science Immunology/3_19.png,vith,3_19.txt,test258NATURE REVIEWS DRUG DISCOVERY,23_4,Which of the following options best describe the cover story?,"Targeting chromatin remodellers, inspired by the Review on p661.259Cover design: S. Harris",A,MAC_Bench/Nature/Cover/NATURE REVIEWS DRUG DISCOVERY/23_4.png,MAC_Bench/Nature/Cover/NATURE REVIEWS DRUG DISCOVERY/23_4.png,groundtruth,23_4.txt,MAC_Bench/Nature/Cover/NATURE REVIEWS DRUG DISCOVERY/22_4.png,MAC_Bench/Nature/Cover/NATURE REVIEWS DRUG DISCOVERY/22_4.png,vith,22_4.txt,MAC_Bench/Nature/Cover/NATURE REVIEWS DRUG DISCOVERY/23_8.png,MAC_Bench/Nature/Cover/NATURE REVIEWS DRUG DISCOVERY/23_8.png,vitg,23_8.txt,MAC_Bench/Nature/Cover/NATURE REVIEWS DRUG DISCOVERY/22_2.png,MAC_Bench/Nature/Cover/NATURE REVIEWS DRUG DISCOVERY/22_2.png,clip,22_2.txt,train260Nature Reviews Psychology,4_1,Which of the following options best describe the cover story?,"In this Review, Cheryan et al. discuss four factors that might explain women’s underrepresentation in some STEM fields and interventions that might help reduce these disparities.261Cover design: David Johnston",B,MAC_Bench/Nature/Cover/Nature Reviews Psychology/3_12.png,MAC_Bench/Nature/Cover/Nature Reviews Psychology/3_12.png,clip,3_12.txt,MAC_Bench/Nature/Cover/Nature Reviews Psychology/4_1.png,MAC_Bench/Nature/Cover/Nature Reviews Psychology/4_1.png,groundtruth,4_1.txt,MAC_Bench/Nature/Cover/Nature Reviews Psychology/3_1.png,MAC_Bench/Nature/Cover/Nature Reviews Psychology/3_1.png,vitg,3_1.txt,MAC_Bench/Nature/Cover/Nature Reviews Psychology/2_11.png,MAC_Bench/Nature/Cover/Nature Reviews Psychology/2_11.png,ave_3,2_11.txt,train262Cell Systems,15_8,Which of the following options best describe the cover story?,"On the cover: VelvetSDE simulations of early neural progenitors differentiating into263motor neurons, V3 interneurons, and floor plate cells, coloured by fate and visualised264in PCA space of VelvetSDE latent space representation. Maizels et al. present methods for dynamical modeling from single-cell transcriptomics: an experimental265protocol for metabolic labeling that provides increased data quality with single-cell266temporal resolution and a generative modeling framework for velocity inference that267outperforms other tools and provides trajectory simulations that capture dynamical268aspects of cell fate decisions. Image credit: the authors.",D,MAC_Bench/Cell/Cover/Cell Systems/13_10.png,MAC_Bench/Cell/Cover/Cell Systems/13_10.png,ave_2,13_10.txt,MAC_Bench/Cell/Cover/Cell Systems/15_9.png,MAC_Bench/Cell/Cover/Cell Systems/15_9.png,clip,15_9.txt,MAC_Bench/Cell/Cover/Cell Systems/15_6.png,MAC_Bench/Cell/Cover/Cell Systems/15_6.png,vith,15_6.txt,MAC_Bench/Cell/Cover/Cell Systems/15_8.png,MAC_Bench/Cell/Cover/Cell Systems/15_8.png,groundtruth,15_8.txt,train269Nature Chemistry,16_7,Which of the following options best describe the cover story?,"Gasoline from plastic waste270Strategies for upcycling waste plastics are urgently required. Now, Han and co-workers have developed a strategy to convert polyethylene into gasoline over a layered self-pillared zeolite without the need for external molecular hydrogen or noble metal catalysts. The reaction proceeds through a self-supplied hydrogen mechanism enabled by the open framework aluminium sites. The cover shows an artistic representation of polyethylene diffusing through zeolite pores and being converted into gasoline.271See Cen et al.272Image: Ziyu Cen and Longfei Lin, Institute of Chemistry, Chinese Academy of Sciences. Cover design: Tulsi Voralia",C,MAC_Bench/Nature/Cover/Nature Chemistry/15_4.png,MAC_Bench/Nature/Cover/Nature Chemistry/15_4.png,clip,15_4.txt,MAC_Bench/Nature/Cover/Nature Chemistry/16_3.png,MAC_Bench/Nature/Cover/Nature Chemistry/16_3.png,vitg,16_3.txt,MAC_Bench/Nature/Cover/Nature Chemistry/16_7.png,MAC_Bench/Nature/Cover/Nature Chemistry/16_7.png,groundtruth,16_7.txt,MAC_Bench/Nature/Cover/Nature Chemistry/16_10.png,MAC_Bench/Nature/Cover/Nature Chemistry/16_10.png,vith,16_10.txt,train273ACS Catalysis,2024_22,Which of the following options best describe the cover story?,"This study modifies the ZSM-5 zeolite support of Au/ZSM-5 catalysts through desilication-recrystallization to increase activity for partial methane oxidation. The treatment notably enhances oxygenate yield, primarily of methanol and acetic acid, by redistributing acid sites across the zeolite surface and stabilizing gold nanoparticles.",D,MAC_Bench/ACS/Cover/ACS Catalysis/2022_9.png,MAC_Bench/ACS/Cover/ACS Catalysis/2022_9.png,vith,2022_9.txt,MAC_Bench/ACS/Cover/ACS Catalysis/2024_12.png,MAC_Bench/ACS/Cover/ACS Catalysis/2024_12.png,vitg,2024_12.txt,MAC_Bench/ACS/Cover/ACS Catalysis/2021_14.png,MAC_Bench/ACS/Cover/ACS Catalysis/2021_14.png,clip,2021_14.txt,MAC_Bench/ACS/Cover/ACS Catalysis/2024_22.png,MAC_Bench/ACS/Cover/ACS Catalysis/2024_22.png,groundtruth,2024_22.txt,train274NATURE IMMUNOLOGY,25_12,Which of the following options best describe the cover story?,"Second-generation M1-polarized CAR macrophages275Induced pluripotent stem (iPS) cell-derived macrophages (iMACs) are being used to engineer CAR macrophages for immunotherapy. Zhang and colleagues design second-generation macrophage-specific CARs by integrating CD3ζ and TIR domains, resulting in M1-polarized CAR-iMACs with increased antitumor functions.276See Zhang et al.277Image credit: Jin Zhang, Zhejiang University. Cover design: Amie Fernandez",B,MAC_Bench/Nature/Cover/NATURE IMMUNOLOGY/24_4.png,MAC_Bench/Nature/Cover/NATURE IMMUNOLOGY/24_4.png,ave_2,24_4.txt,MAC_Bench/Nature/Cover/NATURE IMMUNOLOGY/25_12.png,MAC_Bench/Nature/Cover/NATURE IMMUNOLOGY/25_12.png,groundtruth,25_12.txt,MAC_Bench/Nature/Cover/NATURE IMMUNOLOGY/22_7.png,MAC_Bench/Nature/Cover/NATURE IMMUNOLOGY/22_7.png,vitg,22_7.txt,MAC_Bench/Nature/Cover/NATURE IMMUNOLOGY/22_12.png,MAC_Bench/Nature/Cover/NATURE IMMUNOLOGY/22_12.png,clip,22_12.txt,train278ACS Applied Polymer Materials,2025_1,Which of the following options best describe the cover story?,"A new method for synthesizing urea-based polymers with tetracyanobutadiene chromophores is presented. These polymers show selective turn-on fluorescence when exposed to fluoride ions in a wide range from 30 μM to 7.2 mM. Fluoride disrupts supramolecular aggregates of the polymer, enhancing emission intensity. The background image was generated using the free NinjaTech AI tool.",B,MAC_Bench/ACS/Cover/ACS Applied Polymer Materials/2023_1.png,MAC_Bench/ACS/Cover/ACS Applied Polymer Materials/2023_1.png,vitg,2023_1.txt,MAC_Bench/ACS/Cover/ACS Applied Polymer Materials/2025_1.png,MAC_Bench/ACS/Cover/ACS Applied Polymer Materials/2025_1.png,groundtruth,2025_1.txt,MAC_Bench/ACS/Cover/ACS Applied Polymer Materials/2024_17.png,MAC_Bench/ACS/Cover/ACS Applied Polymer Materials/2024_17.png,vith,2024_17.txt,MAC_Bench/ACS/Cover/ACS Applied Polymer Materials/2024_3.png,MAC_Bench/ACS/Cover/ACS Applied Polymer Materials/2024_3.png,clip,2024_3.txt,test279Nature Aging,4_9,Which of the following options best describe the cover story?,"mTOR, inflammaging and longevity280In this issue, Pingze Zhang et al. reveal that S6K suppression in the fruit-fly fat body mediates the longevity effects of rapamycin, and uncover a sex-dimorphic link through to lysosome morphology and inflammation, via Syntaxin 13. The cover image conceptualizes the link to inflammaging by depicting aged flies as confined to a jar (representing the nuclear localization of the Drosophila NFκB-like transcription factor Relish), emitting brighter light (representing upregulation of inflammatory mediators).281See Zhang et al.282Image: Bruna Di Giacomo, Independent Artist. Cover Design: Lauren Heslop",D,MAC_Bench/Nature/Cover/Nature Aging/3_8.png,MAC_Bench/Nature/Cover/Nature Aging/3_8.png,ave_2,3_8.txt,MAC_Bench/Nature/Cover/Nature Aging/4_8.png,MAC_Bench/Nature/Cover/Nature Aging/4_8.png,vitg,4_8.txt,MAC_Bench/Nature/Cover/Nature Aging/4_5.png,MAC_Bench/Nature/Cover/Nature Aging/4_5.png,clip,4_5.txt,MAC_Bench/Nature/Cover/Nature Aging/4_9.png,MAC_Bench/Nature/Cover/Nature Aging/4_9.png,groundtruth,4_9.txt,train283Science Robotics,9_97,Which of the following options best describe the cover story?,"ONLINE COVER Artificial Intelligence—Solving Decision-Making Problems in Dynamical Systems. Autonomous robots need the ability to adaptively make decisions in unstructured and dynamic environments. Rivière et al. have now developed Spectral Expansion Tree Search, a real-time space planning algorithm that can construct representations of the real world and converge to optimal solutions, enabling autonomous robot decision-making in complex environments. They demonstrated the ability of their framework experimentally with aerial and ground robots with the potential to discover optimal trajectories in complex environments. This month’s cover is an image of a robot mimicking a spacecraft deployed with their framework in a simulated frictionless environment. Credit: Vicki Chiu",B,MAC_Bench/Science/Cover/Science Robotics/9_96.png,MAC_Bench/Science/Cover/Science Robotics/9_96.png,vith,9_96.txt,MAC_Bench/Science/Cover/Science Robotics/9_97.png,MAC_Bench/Science/Cover/Science Robotics/9_97.png,groundtruth,9_97.txt,MAC_Bench/Science/Cover/Science Robotics/9_86.png,MAC_Bench/Science/Cover/Science Robotics/9_86.png,clip,9_86.txt,MAC_Bench/Science/Cover/Science Robotics/7_73.png,MAC_Bench/Science/Cover/Science Robotics/7_73.png,vitg,7_73.txt,train284NATURE BIOTECHNOLOGY,42_9,Which of the following options best describe the cover story?,"Whole-body imaging285Image of a whole mouse body with depth color-coding of a neuronal marker. Mai et al. present wildDISCO, a method for whole-body imaging compatible with standard IgG antibody labeling.286See Mai et al.287Image: Ali Ertürk, Hongcheng Mai, Jie Luo. Cover Design: Erin Dewalt.",C,MAC_Bench/Nature/Cover/NATURE BIOTECHNOLOGY/41_8.png,MAC_Bench/Nature/Cover/NATURE BIOTECHNOLOGY/41_8.png,clip,41_8.txt,MAC_Bench/Nature/Cover/NATURE BIOTECHNOLOGY/41_7.png,MAC_Bench/Nature/Cover/NATURE BIOTECHNOLOGY/41_7.png,ave_3,41_7.txt,MAC_Bench/Nature/Cover/NATURE BIOTECHNOLOGY/42_9.png,MAC_Bench/Nature/Cover/NATURE BIOTECHNOLOGY/42_9.png,groundtruth,42_9.txt,MAC_Bench/Nature/Cover/NATURE BIOTECHNOLOGY/40_1.png,MAC_Bench/Nature/Cover/NATURE BIOTECHNOLOGY/40_1.png,vith,40_1.txt,train288Precision Chemistry,2024_12,Which of the following options best describe the cover story?,"A proline-catalyzed aldol condensation of a glycine Schiff base was developed for the synthesis of α,β-dehydroamino acid derivatives. The synthesized α,β-dehydroamino acid derivatives could be incorporated into peptides not only at the C-terminal but also at the N-terminal.",A,MAC_Bench/ACS/Cover/Precision Chemistry/2024_12.png,MAC_Bench/ACS/Cover/Precision Chemistry/2024_12.png,groundtruth,2024_12.txt,MAC_Bench/ACS/Cover/Precision Chemistry/2023_6.png,MAC_Bench/ACS/Cover/Precision Chemistry/2023_6.png,vitg,2023_6.txt,MAC_Bench/ACS/Cover/Precision Chemistry/2023_1.png,MAC_Bench/ACS/Cover/Precision Chemistry/2023_1.png,clip,2023_1.txt,MAC_Bench/ACS/Cover/Precision Chemistry/2023_8.png,MAC_Bench/ACS/Cover/Precision Chemistry/2023_8.png,vith,2023_8.txt,val289Macromolecules,2024_22,Which of the following options best describe the cover story?,"Synthesis and application of branched polymers are like the root and fruit of a tree. The stronger the root of a tree, the higher the amount of fruit.",B,MAC_Bench/ACS/Cover/Macromolecules/2021_15.png,MAC_Bench/ACS/Cover/Macromolecules/2021_15.png,vith,2021_15.txt,MAC_Bench/ACS/Cover/Macromolecules/2024_22.png,MAC_Bench/ACS/Cover/Macromolecules/2024_22.png,groundtruth,2024_22.txt,MAC_Bench/ACS/Cover/Macromolecules/2019_24.png,MAC_Bench/ACS/Cover/Macromolecules/2019_24.png,vitg,2019_24.txt,MAC_Bench/ACS/Cover/Macromolecules/2016_4.png,MAC_Bench/ACS/Cover/Macromolecules/2016_4.png,clip,2016_4.txt,val290Nature Protocols,19_5,Which of the following options best describe the cover story?,"Illuminating the mechanisms of small-molecule-induced protein proximity and degradation291Small-molecule-induced ternary complexes of NanoLuciferase (NLuc)-fused E3 ligase and a HaloTag-fused neosubstrate are shown. The induced proximity between the two proteins leads to bioluminescence resonance energy transfer (BRET) between the blue luminescent NLuc and the pink BRET acceptor. The formation of these ternary complexes leads to the ubiquitination and subsequent degradation of the neosubstrates by the proteasome as shown in the background.292Image : Martin Schwalm, Goethe University Frankfurt. Cover design: S. Whitham",D,MAC_Bench/Nature/Cover/Nature Protocols/19_6.png,MAC_Bench/Nature/Cover/Nature Protocols/19_6.png,vitg,19_6.txt,MAC_Bench/Nature/Cover/Nature Protocols/20_1.png,MAC_Bench/Nature/Cover/Nature Protocols/20_1.png,clip,20_1.txt,MAC_Bench/Nature/Cover/Nature Protocols/17_6.png,MAC_Bench/Nature/Cover/Nature Protocols/17_6.png,ave_3,17_6.txt,MAC_Bench/Nature/Cover/Nature Protocols/19_5.png,MAC_Bench/Nature/Cover/Nature Protocols/19_5.png,groundtruth,19_5.txt,test293ACS Bio & Med Chem Au,2024_3,Which of the following options best describe the cover story?,Hwang et al. develop a new sustainable bioproduction platform to generate disulfide-constrained peptide (DCP) and its functionalized analogues. DCPs are targeted to the periplasm in E.,D,MAC_Bench/ACS/Cover/ACS Bio & Med Chem Au/2023_1.png,MAC_Bench/ACS/Cover/ACS Bio & Med Chem Au/2023_1.png,vitg,2023_1.txt,MAC_Bench/ACS/Cover/ACS Bio & Med Chem Au/2022_3.png,MAC_Bench/ACS/Cover/ACS Bio & Med Chem Au/2022_3.png,clip,2022_3.txt,MAC_Bench/ACS/Cover/ACS Bio & Med Chem Au/2023_5.png,MAC_Bench/ACS/Cover/ACS Bio & Med Chem Au/2023_5.png,vith,2023_5.txt,MAC_Bench/ACS/Cover/ACS Bio & Med Chem Au/2024_3.png,MAC_Bench/ACS/Cover/ACS Bio & Med Chem Au/2024_3.png,groundtruth,2024_3.txt,train294Nature Cell Biology,26_7,Which of the following options best describe the cover story?,"RNA binding in glioblastoma295The authors show that the RNA–RNA-binding protein complex LOC–DHX15 drives microglia infiltration into the tumour microenvironment in glioblastoma.296See Wu, Zhao, Shin & Yin et al.297Image: Wu Lele, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore. Cover design: Lauren Heslop",C,MAC_Bench/Nature/Cover/Nature Cell Biology/26_8.png,MAC_Bench/Nature/Cover/Nature Cell Biology/26_8.png,vith,26_8.txt,MAC_Bench/Nature/Cover/Nature Cell Biology/25_10.png,MAC_Bench/Nature/Cover/Nature Cell Biology/25_10.png,vitg,25_10.txt,MAC_Bench/Nature/Cover/Nature Cell Biology/26_7.png,MAC_Bench/Nature/Cover/Nature Cell Biology/26_7.png,groundtruth,26_7.txt,MAC_Bench/Nature/Cover/Nature Cell Biology/24_4.png,MAC_Bench/Nature/Cover/Nature Cell Biology/24_4.png,clip,24_4.txt,val298Nature Reviews Physics,6_8,Which of the following options best describe the cover story?,"The cover of this issue refers to the new collection `Physics as a Human Endeavour’. See Editorial299Cover design: Susanne Harris.",D,MAC_Bench/Nature/Cover/Nature Reviews Physics/5_8.png,MAC_Bench/Nature/Cover/Nature Reviews Physics/5_8.png,vitg,5_8.txt,MAC_Bench/Nature/Cover/Nature Reviews Physics/5_10.png,MAC_Bench/Nature/Cover/Nature Reviews Physics/5_10.png,clip,5_10.txt,MAC_Bench/Nature/Cover/Nature Reviews Physics/6_3.png,MAC_Bench/Nature/Cover/Nature Reviews Physics/6_3.png,ave_2,6_3.txt,MAC_Bench/Nature/Cover/Nature Reviews Physics/6_8.png,MAC_Bench/Nature/Cover/Nature Reviews Physics/6_8.png,groundtruth,6_8.txt,train300ACS Synthetic Biology,2025_1,Which of the following options best describe the cover story?,"The key economic indicators, namely, titer, rate, and yield (TRY) that, respectively, reflect the downstream processing, reactor size, and raw material costs, serve as useful ways to benchmark intensified fermentation processes. BioTRY provides a user-friendly interface for querying, browsing, and visualizing TRY records in microbial processes.",B,MAC_Bench/ACS/Cover/ACS Synthetic Biology/2024_7.png,MAC_Bench/ACS/Cover/ACS Synthetic Biology/2024_7.png,ave_3,2024_7.txt,MAC_Bench/ACS/Cover/ACS Synthetic Biology/2025_1.png,MAC_Bench/ACS/Cover/ACS Synthetic Biology/2025_1.png,groundtruth,2025_1.txt,MAC_Bench/ACS/Cover/ACS Synthetic Biology/2022_12.png,MAC_Bench/ACS/Cover/ACS Synthetic Biology/2022_12.png,clip,2022_12.txt,MAC_Bench/ACS/Cover/ACS Synthetic Biology/2022_11.png,MAC_Bench/ACS/Cover/ACS Synthetic Biology/2022_11.png,ave_2,2022_11.txt,train301Cell Systems,15_12,Which of the following options best describe the cover story?,"On the cover: Illustration of a microbial community. In this issue of Cell Systems, Wang et al. show that optimizing metabolic specialization and versatility of individuals within302a microbial consortium yields a metabolic division of labor configuration with the303highest function. Image credit: Getty Images.",B,MAC_Bench/Cell/Cover/Cell Systems/15_10.png,MAC_Bench/Cell/Cover/Cell Systems/15_10.png,vitg,15_10.txt,MAC_Bench/Cell/Cover/Cell Systems/15_12.png,MAC_Bench/Cell/Cover/Cell Systems/15_12.png,groundtruth,15_12.txt,MAC_Bench/Cell/Cover/Cell Systems/15_7.png,MAC_Bench/Cell/Cover/Cell Systems/15_7.png,clip,15_7.txt,MAC_Bench/Cell/Cover/Cell Systems/13_1.png,MAC_Bench/Cell/Cover/Cell Systems/13_1.png,vith,13_1.txt,train304Matter,8_2,Which of the following options best describe the cover story?,"On the cover: This cover features conductive thin films designed to protect drones305in extreme weather conditions. In this issue, Wu and colleagues explore material engineering through the integration of experiments and theories.306By combining layer-by-layer assembly and graph theory, electrical properties are modeled307based on the complex structures of the nanoscale networks. Image courtesy of the authors.",A,MAC_Bench/Cell/Cover/Matter/8_2.png,MAC_Bench/Cell/Cover/Matter/8_2.png,groundtruth,8_2.txt,MAC_Bench/Cell/Cover/Matter/8_1.png,MAC_Bench/Cell/Cover/Matter/8_1.png,clip,8_1.txt,MAC_Bench/Cell/Cover/Matter/6_4.png,MAC_Bench/Cell/Cover/Matter/6_4.png,ave_2,6_4.txt,MAC_Bench/Cell/Cover/Matter/5_8.png,MAC_Bench/Cell/Cover/Matter/5_8.png,ave_3,5_8.txt,test308ACS Medicinal Chemistry Letters,2017_9,Which of the following options best describe the cover story?,"X-ray crystal structure of the carboplatin-loaded ferritin nanocage (PDB code 5MIJ). Pt centers coordinate to His49 and His132, on the inner surface of the Ft nanocage. ACS Med. Chem. Lett. DOI: 10.1021/acsmedchemlett.7b00025. View the article.",A,MAC_Bench/ACS/Cover/ACS Medicinal Chemistry Letters/2017_9.png,MAC_Bench/ACS/Cover/ACS Medicinal Chemistry Letters/2017_9.png,groundtruth,2017_9.txt,MAC_Bench/ACS/Cover/ACS Medicinal Chemistry Letters/2025_2.png,MAC_Bench/ACS/Cover/ACS Medicinal Chemistry Letters/2025_2.png,ave_3,2025_2.txt,MAC_Bench/ACS/Cover/ACS Medicinal Chemistry Letters/2025_1.png,MAC_Bench/ACS/Cover/ACS Medicinal Chemistry Letters/2025_1.png,ave_2,2025_1.txt,MAC_Bench/ACS/Cover/ACS Medicinal Chemistry Letters/2017_4.png,MAC_Bench/ACS/Cover/ACS Medicinal Chemistry Letters/2017_4.png,clip,2017_4.txt,test309Accounts of Chemical Research,2024_12,Which of the following options best describe the cover story?,Membrane-spanning α-helical peptide pores for single-molecule sensing.,A,MAC_Bench/ACS/Cover/Accounts of Chemical Research/2024_12.png,MAC_Bench/ACS/Cover/Accounts of Chemical Research/2024_12.png,groundtruth,2024_12.txt,MAC_Bench/ACS/Cover/Accounts of Chemical Research/2024_1.png,MAC_Bench/ACS/Cover/Accounts of Chemical Research/2024_1.png,clip,2024_1.txt,MAC_Bench/ACS/Cover/Accounts of Chemical Research/2023_22.png,MAC_Bench/ACS/Cover/Accounts of Chemical Research/2023_22.png,vith,2023_22.txt,MAC_Bench/ACS/Cover/Accounts of Chemical Research/2024_16.png,MAC_Bench/ACS/Cover/Accounts of Chemical Research/2024_16.png,vitg,2024_16.txt,val310ACS Polymers Au,2024_3,Which of the following options best describe the cover story?,"Schematic representation of large size polar aggregates formed via hydrogen bonding between phosphate-terminated cis-1,4-polyisoprene chains in natural rubber (NR). The presence of multiple large size phosphate aggregates suggests a potential mechanism contributing to the superior comprehensive properties such as strain-induced crystallization observed in NR compared to synthetic polyisoprene.",B,MAC_Bench/ACS/Cover/ACS Polymers Au/2023_6.png,MAC_Bench/ACS/Cover/ACS Polymers Au/2023_6.png,clip,2023_6.txt,MAC_Bench/ACS/Cover/ACS Polymers Au/2024_3.png,MAC_Bench/ACS/Cover/ACS Polymers Au/2024_3.png,groundtruth,2024_3.txt,MAC_Bench/ACS/Cover/ACS Polymers Au/2022_6.png,MAC_Bench/ACS/Cover/ACS Polymers Au/2022_6.png,vith,2022_6.txt,MAC_Bench/ACS/Cover/ACS Polymers Au/2024_4.png,MAC_Bench/ACS/Cover/ACS Polymers Au/2024_4.png,ave_3,2024_4.txt,test311Structure,32_7,Which of the following options best describe the cover story?,"On the cover: In this piece, a flower garden provides a metaphor for the creation312and growth of designed protein assemblies. Meador et al. describe machine learning algorithms that greatly expand the ability to generate313new types of protein-based molecular cages, whose beauty and diversity are reminiscent314of natural flora. Image credit: Nika Gladkov.",C,MAC_Bench/Cell/Cover/Structure/26_10.png,MAC_Bench/Cell/Cover/Structure/26_10.png,ave_1,26_10.txt,MAC_Bench/Cell/Cover/Structure/25_2.png,MAC_Bench/Cell/Cover/Structure/25_2.png,vitg,25_2.txt,MAC_Bench/Cell/Cover/Structure/32_7.png,MAC_Bench/Cell/Cover/Structure/32_7.png,groundtruth,32_7.txt,MAC_Bench/Cell/Cover/Structure/30_11.png,MAC_Bench/Cell/Cover/Structure/30_11.png,clip,30_11.txt,train315Trends in Microbiology,32_7,Which of the following options best describe the cover story?,"Nitrogen (N) is absolutely essential to life as we know it. Though316atmospherically abundant, N must first be converted, or “fixed,” prior to biological317uptake318and crop fertilizer manufacturing. Synthetic N-fixation, today responsible for half319of all fixed320N, comes with profound economic and environmental costs. Fortunately, an alternative,321ancient biological strategy—catalyzed by microbially hosted nitrogenase proteins—holds322enormous bioengineering potential for sustainable N-fixation. Yet, researchers have323been324unable to mimic this elegant biological solution and lack an understanding of environmental325drivers in its evolution, limiting predictions for how biological N-fixation will326respond to a327changing climate. In this special issue, Holly Rucker and Betül Kaçar review the complex328history of nitrogen fixation over billions of years of planetary history.329Image courtesy: Prof. Betül Kaçar, UW-Madison.",B,MAC_Bench/Cell/Cover/Trends in Microbiology/32_5.png,MAC_Bench/Cell/Cover/Trends in Microbiology/32_5.png,ave_2,32_5.txt,MAC_Bench/Cell/Cover/Trends in Microbiology/32_7.png,MAC_Bench/Cell/Cover/Trends in Microbiology/32_7.png,groundtruth,32_7.txt,MAC_Bench/Cell/Cover/Trends in Microbiology/32_8.png,MAC_Bench/Cell/Cover/Trends in Microbiology/32_8.png,clip,32_8.txt,MAC_Bench/Cell/Cover/Trends in Microbiology/32_6.png,MAC_Bench/Cell/Cover/Trends in Microbiology/32_6.png,ave_3,32_6.txt,train330The Journal of Physical Chemistry B,2025_6,Which of the following options best describe the cover story?,"The monomeric KMP-11 phase separates to form liquid-like condensates. Different physiological factors, like temperature and pH, play vital roles in this process. Alternate charge block or (+)ve–",B,MAC_Bench/ACS/Cover/The Journal of Physical Chemistry B/2022_22.png,MAC_Bench/ACS/Cover/The Journal of Physical Chemistry B/2022_22.png,ave_1,2022_22.txt,MAC_Bench/ACS/Cover/The Journal of Physical Chemistry B/2025_6.png,MAC_Bench/ACS/Cover/The Journal of Physical Chemistry B/2025_6.png,groundtruth,2025_6.txt,MAC_Bench/ACS/Cover/The Journal of Physical Chemistry B/2022_24.png,MAC_Bench/ACS/Cover/The Journal of Physical Chemistry B/2022_24.png,vitg,2022_24.txt,MAC_Bench/ACS/Cover/The Journal of Physical Chemistry B/2024_8.png,MAC_Bench/ACS/Cover/The Journal of Physical Chemistry B/2024_8.png,clip,2024_8.txt,train331Nature Chemical Biology,20_1,Which of the following options best describe the cover story?,"A mark for degradation332Seabrook et al. developed MrTAC, a targeted protein degradation modality using arginine methylation to shuttle intracellular proteins to lysosomes for rapid degradation. The cover shows a confocal microscopy image of methylated proteins (gold) in HeLa cells organizing into cytosolic puncta with a nuclear costain (DAPI, blue).333See Seabrook et al. and Research Briefing334Image: Laurence Seabrook, University of California, Irvine. Cover design: Alex Wing",C,MAC_Bench/Nature/Cover/Nature Chemical Biology/20_8.png,MAC_Bench/Nature/Cover/Nature Chemical Biology/20_8.png,clip,20_8.txt,MAC_Bench/Nature/Cover/Nature Chemical Biology/17_7.png,MAC_Bench/Nature/Cover/Nature Chemical Biology/17_7.png,vitg,17_7.txt,MAC_Bench/Nature/Cover/Nature Chemical Biology/20_1.png,MAC_Bench/Nature/Cover/Nature Chemical Biology/20_1.png,groundtruth,20_1.txt,MAC_Bench/Nature/Cover/Nature Chemical Biology/17_12.png,MAC_Bench/Nature/Cover/Nature Chemical Biology/17_12.png,ave_3,17_12.txt,test335Accounts of Chemical Research,2024_13,Which of the following options best describe the cover story?,"Falling from the heavens, C60 fullerene and its derivatives have continued to bring surprises to humans in a variety of fields. This Account discussed the multifaceted properties and applications of fullerene–metal complexes and clusters, ranging from fundamental structural chemistry to the forefront of single atom catalysis and to astrophysics and astrochemistry.",D,MAC_Bench/ACS/Cover/Accounts of Chemical Research/2015_8.png,MAC_Bench/ACS/Cover/Accounts of Chemical Research/2015_8.png,clip,2015_8.txt,MAC_Bench/ACS/Cover/Accounts of Chemical Research/2008_10.png,MAC_Bench/ACS/Cover/Accounts of Chemical Research/2008_10.png,vitg,2008_10.txt,MAC_Bench/ACS/Cover/Accounts of Chemical Research/2024_15.png,MAC_Bench/ACS/Cover/Accounts of Chemical Research/2024_15.png,vith,2024_15.txt,MAC_Bench/ACS/Cover/Accounts of Chemical Research/2024_13.png,MAC_Bench/ACS/Cover/Accounts of Chemical Research/2024_13.png,groundtruth,2024_13.txt,train336Developmental Cell,59_18,Which of the following options best describe the cover story?,"On the cover: The image is a graphical representation for the information that can337be obtained from the human liver by a spatial single-cell multi-omic approach. Data338(in blue, water gas cluster ion beam secondary ion mass spectrometry [(H2O)n-GCIB-SIMS] imaging; in red, desorption electrospray ionization mass spectrometry339imaging [DESI-MSI]; and in green, C60-SIMS imaging) identify the metabolic and cellular organization of the liver. To learn340more about how spatial multi-omics provides insight into cell types in the mammalian341liver, see Tian et al. Image credit: Hua Tian and Ella Maru Studio.",B,MAC_Bench/Cell/Cover/Developmental Cell/59_16.png,MAC_Bench/Cell/Cover/Developmental Cell/59_16.png,ave_3,59_16.txt,MAC_Bench/Cell/Cover/Developmental Cell/59_18.png,MAC_Bench/Cell/Cover/Developmental Cell/59_18.png,groundtruth,59_18.txt,MAC_Bench/Cell/Cover/Developmental Cell/59_14.png,MAC_Bench/Cell/Cover/Developmental Cell/59_14.png,clip,59_14.txt,MAC_Bench/Cell/Cover/Developmental Cell/58_16.png,MAC_Bench/Cell/Cover/Developmental Cell/58_16.png,ave_2,58_16.txt,train342Biophysical Reports,4_3,Which of the following options best describe the cover story?,"On the cover: Tetraspanin proteins (TSPANs) are found in all cell types and are involved in functions343like cell adhesion, membrane fusion, and cancer metastasis, mainly through their ability344to form higher-order structures. Their assembly depends on membrane concentration,345which can increase in curved membranes for some tetraspanins because of their sensitivity346to membrane curvature. To understand how different parts of the protein contribute347to its assembly and curvature sensitivity, micropipette aspiration combined with confocal348microscopy and optical tweezers was used. The illustration depicts a vesicle containing349TSPAN4 proteins held in a micropippete, with a membrane tube pulled from it by using350an optically trapped bead. Upon tube formation, the proteins partition into the tube.351By using this assay, it was demonstrated that the protein's extracellular loop 2 contributes352to the curvature sensitivity and curvature-induced interactions of TSPAN4. DOI: https://doi.org/10.1016/j.bpr.2024.100149",C,MAC_Bench/Cell/Cover/Biophysical Reports/2_3.png,MAC_Bench/Cell/Cover/Biophysical Reports/2_3.png,ave_2,2_3.txt,MAC_Bench/Cell/Cover/Biophysical Reports/1_1.png,MAC_Bench/Cell/Cover/Biophysical Reports/1_1.png,clip,1_1.txt,MAC_Bench/Cell/Cover/Biophysical Reports/4_3.png,MAC_Bench/Cell/Cover/Biophysical Reports/4_3.png,groundtruth,4_3.txt,MAC_Bench/Cell/Cover/Biophysical Reports/4_4.png,MAC_Bench/Cell/Cover/Biophysical Reports/4_4.png,vith,4_4.txt,train353ACS Sensors,2024_3,Which of the following options best describe the cover story?,"Ripe pears can undergo alcoholic fermentation. They release ethanol. Our system, based on enzymatic reactions, can image the distribution of ethanol released from pears. In other words, it is a conversion of odor information into visual information. It is expected that intelligent olfactory sensor systems will be used in agriculture, for example, to locate and sort ripe fruit based on odor-visual information.",A,MAC_Bench/ACS/Cover/ACS Sensors/2024_3.png,MAC_Bench/ACS/Cover/ACS Sensors/2024_3.png,groundtruth,2024_3.txt,MAC_Bench/ACS/Cover/ACS Sensors/2023_3.png,MAC_Bench/ACS/Cover/ACS Sensors/2023_3.png,clip,2023_3.txt,MAC_Bench/ACS/Cover/ACS Sensors/2022_12.png,MAC_Bench/ACS/Cover/ACS Sensors/2022_12.png,vith,2022_12.txt,MAC_Bench/ACS/Cover/ACS Sensors/2017_11.png,MAC_Bench/ACS/Cover/ACS Sensors/2017_11.png,vitg,2017_11.txt,train354ACS ES&T Water,2024_7,Which of the following options best describe the cover story?,This work shows the marriage of single atoms with nanoparticles for enhanced peroxymonosulfate (PMS) activation. The built-in electric field assisted Co SAs for efficient PMS activation via a nonradical pathway.,C,MAC_Bench/ACS/Cover/ACS ES&T Water/2024_5.png,MAC_Bench/ACS/Cover/ACS ES&T Water/2024_5.png,vitg,2024_5.txt,MAC_Bench/ACS/Cover/ACS ES&T Water/2021_3.png,MAC_Bench/ACS/Cover/ACS ES&T Water/2021_3.png,clip,2021_3.txt,MAC_Bench/ACS/Cover/ACS ES&T Water/2024_7.png,MAC_Bench/ACS/Cover/ACS ES&T Water/2024_7.png,groundtruth,2024_7.txt,MAC_Bench/ACS/Cover/ACS ES&T Water/2021_8.png,MAC_Bench/ACS/Cover/ACS ES&T Water/2021_8.png,ave_3,2021_8.txt,val355ACS Applied Polymer Materials,2024_3,Which of the following options best describe the cover story?,"The cover art depicts a biomimetic 3D-printed armored structure inspired by armadillo shells for durable superhydrophobic surfaces. It showcases hexagonal patterns protecting inner hydrophobic nanoparticles, repelling water droplets. The design illustrates the approach of integrating 3D printing with nanomaterial surface treatments to create wear-resistant, water-repellent coatings for harsh environments.",B,MAC_Bench/ACS/Cover/ACS Applied Polymer Materials/2024_4.png,MAC_Bench/ACS/Cover/ACS Applied Polymer Materials/2024_4.png,ave_2,2024_4.txt,MAC_Bench/ACS/Cover/ACS Applied Polymer Materials/2024_3.png,MAC_Bench/ACS/Cover/ACS Applied Polymer Materials/2024_3.png,groundtruth,2024_3.txt,MAC_Bench/ACS/Cover/ACS Applied Polymer Materials/2022_6.png,MAC_Bench/ACS/Cover/ACS Applied Polymer Materials/2022_6.png,ave_3,2022_6.txt,MAC_Bench/ACS/Cover/ACS Applied Polymer Materials/2024_17.png,MAC_Bench/ACS/Cover/ACS Applied Polymer Materials/2024_17.png,clip,2024_17.txt,train356ACS Applied Optical Materials,2024_10,Which of the following options best describe the cover story?,A novel inorganic–organic framework composed of layered clay nanosheets bridged by a pillar-shaped multicationic double-decker porphyrin metal complex having long alkyl sidechains was synthesized through a cation exchange reaction and applied for an efficient adsorbent for various anionic organic dyes.,A,MAC_Bench/ACS/Cover/ACS Applied Optical Materials/2024_10.png,MAC_Bench/ACS/Cover/ACS Applied Optical Materials/2024_10.png,groundtruth,2024_10.txt,MAC_Bench/ACS/Cover/ACS Applied Optical Materials/2024_5.png,MAC_Bench/ACS/Cover/ACS Applied Optical Materials/2024_5.png,ave_3,2024_5.txt,MAC_Bench/ACS/Cover/ACS Applied Optical Materials/2024_8.png,MAC_Bench/ACS/Cover/ACS Applied Optical Materials/2024_8.png,clip,2024_8.txt,MAC_Bench/ACS/Cover/ACS Applied Optical Materials/2024_2.png,MAC_Bench/ACS/Cover/ACS Applied Optical Materials/2024_2.png,vitg,2024_2.txt,test357Journal of Chemical Education,2021_12,Which of the following options best describe the cover story?,"Modern chemistry programs must include the skills and techniques that enable their graduates to perform experiments safely. In response to a call for papers, scientists and educators from around the world have contributed articles to the Journal of Chemical Education's Special Issue on Chemical Safety Education: Methods, Culture, and Green Chemistry. The articles in the issue are broadly distributed among topics covering resources, green chemistry, safety culture, and pedagogy. This issue is a resource for ideas and discussion to encourage ""a new way to look at safety"", with a focus on assessing hazards, minimizing risk, and valuing a strong chemical safety culture. (Cover image courtesy of Jane E. Wissinger.)",D,MAC_Bench/ACS/Cover/Journal of Chemical Education/2015_12.png,MAC_Bench/ACS/Cover/Journal of Chemical Education/2015_12.png,vitg,2015_12.txt,MAC_Bench/ACS/Cover/Journal of Chemical Education/2019_6.png,MAC_Bench/ACS/Cover/Journal of Chemical Education/2019_6.png,clip,2019_6.txt,MAC_Bench/ACS/Cover/Journal of Chemical Education/2019_5.png,MAC_Bench/ACS/Cover/Journal of Chemical Education/2019_5.png,vith,2019_5.txt,MAC_Bench/ACS/Cover/Journal of Chemical Education/2021_12.png,MAC_Bench/ACS/Cover/Journal of Chemical Education/2021_12.png,groundtruth,2021_12.txt,train358Industrial & Engineering Chemistry Research,2024_37,Which of the following options best describe the cover story?,"The high concentration of oxygen vacancies on Ni/CeO2-NS facilitates the activation of water and oxygen molecules during methanol oxidative steam reforming, leading to enhanced conversion of methanol to hydrogen.",A,MAC_Bench/ACS/Cover/Industrial & Engineering Chemistry Research/2024_37.png,MAC_Bench/ACS/Cover/Industrial & Engineering Chemistry Research/2024_37.png,groundtruth,2024_37.txt,MAC_Bench/ACS/Cover/Industrial & Engineering Chemistry Research/2024_33.png,MAC_Bench/ACS/Cover/Industrial & Engineering Chemistry Research/2024_33.png,clip,2024_33.txt,MAC_Bench/ACS/Cover/Industrial & Engineering Chemistry Research/2024_25.png,MAC_Bench/ACS/Cover/Industrial & Engineering Chemistry Research/2024_25.png,vith,2024_25.txt,MAC_Bench/ACS/Cover/Industrial & Engineering Chemistry Research/2023_13.png,MAC_Bench/ACS/Cover/Industrial & Engineering Chemistry Research/2023_13.png,vitg,2023_13.txt,val359Current Biology,34_20,Which of the following options best describe the cover story?,"On the cover: Gibbons are well known for their melodious morning song bouts. In this360issue, Ma et al. show that three adult male crested gibbon species adjust rhythm to facilitate song361coordination with adult females. This image shows an adult male cao vit gibbon (Nomascus nasutus), one of the study species with a particularly strong adjustment in rhythm. This362species is Critically Endangered, with only one population of 74 individuals, calling363for urgent conservation. Photo by Chao Zhao.",A,MAC_Bench/Cell/Cover/Current Biology/34_20.png,MAC_Bench/Cell/Cover/Current Biology/34_20.png,groundtruth,34_20.txt,MAC_Bench/Cell/Cover/Current Biology/29_15.png,MAC_Bench/Cell/Cover/Current Biology/29_15.png,clip,29_15.txt,MAC_Bench/Cell/Cover/Current Biology/30_19.png,MAC_Bench/Cell/Cover/Current Biology/30_19.png,vitg,30_19.txt,MAC_Bench/Cell/Cover/Current Biology/32_7.png,MAC_Bench/Cell/Cover/Current Biology/32_7.png,ave_3,32_7.txt,train364Nature Reviews Physics,6_12,Which of the following options best describe the cover story?,"The cover of this issue shows an artistic representation of the equations of state of the periodic table elements, calculated using two all-electron codes in each of the 10 crystal structure configurations shown on the table. See Bosoni et al.365Image: Giovanni Pizzi, EPFL, Switzerland. Cover design: Susanne Harris.",B,MAC_Bench/Nature/Cover/Nature Reviews Physics/6_1.png,MAC_Bench/Nature/Cover/Nature Reviews Physics/6_1.png,vith,6_1.txt,MAC_Bench/Nature/Cover/Nature Reviews Physics/6_12.png,MAC_Bench/Nature/Cover/Nature Reviews Physics/6_12.png,groundtruth,6_12.txt,MAC_Bench/Nature/Cover/Nature Reviews Physics/6_5.png,MAC_Bench/Nature/Cover/Nature Reviews Physics/6_5.png,vitg,6_5.txt,MAC_Bench/Nature/Cover/Nature Reviews Physics/7_1.png,MAC_Bench/Nature/Cover/Nature Reviews Physics/7_1.png,clip,7_1.txt,train366Nature Sustainability,7_3,Which of the following options best describe the cover story?,"Ancient soil enrichment367Amazonian dark earth, rich soil resulting from ancient human land modification, has the potential to store substantial amounts of carbon, yet the number and size of Amazonian dark earth sites is unknown. Goldberg and colleagues develop a remote-sensing approach leveraging machine-learning classifiers to reveal its present extent.368See Goldberg et al.369Image: Bruno Moraes Puente Institute, (Nederland, CO, USA) and the Amazon Hopes Collective. Cover design: Alex Whitworth",A,MAC_Bench/Nature/Cover/Nature Sustainability/7_3.png,MAC_Bench/Nature/Cover/Nature Sustainability/7_3.png,groundtruth,7_3.txt,MAC_Bench/Nature/Cover/Nature Sustainability/4_2.png,MAC_Bench/Nature/Cover/Nature Sustainability/4_2.png,ave_3,4_2.txt,MAC_Bench/Nature/Cover/Nature Sustainability/5_8.png,MAC_Bench/Nature/Cover/Nature Sustainability/5_8.png,clip,5_8.txt,MAC_Bench/Nature/Cover/Nature Sustainability/4_11.png,MAC_Bench/Nature/Cover/Nature Sustainability/4_11.png,ave_2,4_11.txt,train370NATURE METHODS,21_5,Which of the following options best describe the cover story?,"Focus on advanced AI in biology371Advanced artificial intelligence (AI)-based methods are having a transformative impact on biological research, as explored in this special issue.372See Editorial373Image: Weiquan Lin / Getty Images. Cover design: Thomas Phillips",B,MAC_Bench/Nature/Cover/NATURE METHODS/20_6.png,MAC_Bench/Nature/Cover/NATURE METHODS/20_6.png,clip,20_6.txt,MAC_Bench/Nature/Cover/NATURE METHODS/21_5.png,MAC_Bench/Nature/Cover/NATURE METHODS/21_5.png,groundtruth,21_5.txt,MAC_Bench/Nature/Cover/NATURE METHODS/22_1.png,MAC_Bench/Nature/Cover/NATURE METHODS/22_1.png,vitg,22_1.txt,MAC_Bench/Nature/Cover/NATURE METHODS/19_4.png,MAC_Bench/Nature/Cover/NATURE METHODS/19_4.png,vith,19_4.txt,test374Joule,9_1,Which of the following options best describe the cover story?,"On the cover: In this cover image, Chen et al. present the conceptual design of a new electro-biodiesel platform that converts CO2 into biodiesel by integrating electrocatalysis and microbial bioconversion. The image375illustrates the integrated electro-biodiesel conversion process, where electrocatalytic376reactors convert CO2 into biocompatible C2 intermediates, which are then upgraded into biodiesel precursors377through efficient microbial fermentation. The process flow is shown by the bright378pathway. The transparent container at the center symbolizes the final diesel product.379The image highlights the advancement of an efficient and economic electro-biodiesel380route through the co-design of microbes and catalysts, opening new avenues for sustainable381CO2 conversion. Artist: Yu Zhang (@CYANTIFICA).",B,MAC_Bench/Cell/Cover/Joule/9_2.png,MAC_Bench/Cell/Cover/Joule/9_2.png,clip,9_2.txt,MAC_Bench/Cell/Cover/Joule/9_1.png,MAC_Bench/Cell/Cover/Joule/9_1.png,groundtruth,9_1.txt,MAC_Bench/Cell/Cover/Joule/5_2.png,MAC_Bench/Cell/Cover/Joule/5_2.png,ave_3,5_2.txt,MAC_Bench/Cell/Cover/Joule/5_10.png,MAC_Bench/Cell/Cover/Joule/5_10.png,ave_2,5_10.txt,train382Nature Reviews Clinical Oncology,21_9,Which of the following options best describe the cover story?,"Dendritic cells as orchestrators of immune responses, inspired by the Review on p257.383Cover design: Lara Crow",D,MAC_Bench/Nature/Cover/Nature Reviews Clinical Oncology/21_6.png,MAC_Bench/Nature/Cover/Nature Reviews Clinical Oncology/21_6.png,vitg,21_6.txt,MAC_Bench/Nature/Cover/Nature Reviews Clinical Oncology/20_11.png,MAC_Bench/Nature/Cover/Nature Reviews Clinical Oncology/20_11.png,vith,20_11.txt,MAC_Bench/Nature/Cover/Nature Reviews Clinical Oncology/20_4.png,MAC_Bench/Nature/Cover/Nature Reviews Clinical Oncology/20_4.png,clip,20_4.txt,MAC_Bench/Nature/Cover/Nature Reviews Clinical Oncology/21_9.png,MAC_Bench/Nature/Cover/Nature Reviews Clinical Oncology/21_9.png,groundtruth,21_9.txt,test384ACS Chemical Neuroscience,2024_15,Which of the following options best describe the cover story?,"Cryo-section of one hemisphere from 18-month-old Alzheimer's disease pathology mouse model APP23 stained with two conformation-sensitive amyloid dyes, qFTAA and hFTAA: The dyes are used to visualize structural differences in amyloid depositions in several mouse models. The inset shows single plaques (artistic rendering of confocal fluorescence micrographs).",D,MAC_Bench/ACS/Cover/ACS Chemical Neuroscience/2024_19.png,MAC_Bench/ACS/Cover/ACS Chemical Neuroscience/2024_19.png,clip,2024_19.txt,MAC_Bench/ACS/Cover/ACS Chemical Neuroscience/2021_18.png,MAC_Bench/ACS/Cover/ACS Chemical Neuroscience/2021_18.png,vitg,2021_18.txt,MAC_Bench/ACS/Cover/ACS Chemical Neuroscience/2021_5.png,MAC_Bench/ACS/Cover/ACS Chemical Neuroscience/2021_5.png,ave_2,2021_5.txt,MAC_Bench/ACS/Cover/ACS Chemical Neuroscience/2024_15.png,MAC_Bench/ACS/Cover/ACS Chemical Neuroscience/2024_15.png,groundtruth,2024_15.txt,test385Cell Reports Methods,4_10,Which of the following options best describe the cover story?,"On the cover: In this issue, Shinde et al. present CMI-PB, a data resource and challenge contest to develop computational models386predicting vaccine responses. The cover image draws inspiration from the “blind man387and elephant” parable, showing blindfolded scientists each bringing their own expertise388to solve a multifaceted systems biology problem represented by the elephant and involving389the multi-omics datatypes represented at the top. Courtesy: Unsplash (Wolfgang Hasselmann)390and BioRender.",A,MAC_Bench/Cell/Cover/Cell Reports Methods/4_10.png,MAC_Bench/Cell/Cover/Cell Reports Methods/4_10.png,groundtruth,4_10.txt,MAC_Bench/Cell/Cover/Cell Reports Methods/4_9.png,MAC_Bench/Cell/Cover/Cell Reports Methods/4_9.png,clip,4_9.txt,MAC_Bench/Cell/Cover/Cell Reports Methods/5_1.png,MAC_Bench/Cell/Cover/Cell Reports Methods/5_1.png,ave_1,5_1.txt,MAC_Bench/Cell/Cover/Cell Reports Methods/3_10.png,MAC_Bench/Cell/Cover/Cell Reports Methods/3_10.png,vitg,3_10.txt,train391ACS Infectious Diseases,2024_2,Which of the following options best describe the cover story?,HBV persistence in the host cells is mediated by several regulatory proteins. E3 ubiquitin ligase UBR7 plays a crucial role in suppressing the IFN-β signaling and promotes viral proliferation leading to HBV-induced HCC.,D,MAC_Bench/ACS/Cover/ACS Infectious Diseases/2017_1.png,MAC_Bench/ACS/Cover/ACS Infectious Diseases/2017_1.png,vitg,2017_1.txt,MAC_Bench/ACS/Cover/ACS Infectious Diseases/2024_5.png,MAC_Bench/ACS/Cover/ACS Infectious Diseases/2024_5.png,ave_1,2024_5.txt,MAC_Bench/ACS/Cover/ACS Infectious Diseases/2024_1.png,MAC_Bench/ACS/Cover/ACS Infectious Diseases/2024_1.png,clip,2024_1.txt,MAC_Bench/ACS/Cover/ACS Infectious Diseases/2024_2.png,MAC_Bench/ACS/Cover/ACS Infectious Diseases/2024_2.png,groundtruth,2024_2.txt,train392Trendsin Neurosciences,48_1,Which of the following options best describe the cover story?,"The amygdala is a multi-nuclear limbic system structure that functions393as a primary processing center for social and emotional behaviors in the vertebrate394brain. The term ‘amygdala’ comes from the Greek word for ‘almond’ due to its395characteristic ovoid shape. In this issue of Trends in Neurosciences, Joshua Corbin396and colleagues review how one of the key nuclei of the amygdala, the medial397amygdala, is formed from embryonic development and how these developmental398programs may drive the emergences of innate social behaviors. The cover image399shows an almond tree at two stages of its lifecycle; during springtime when flowers400are blooming and during summer when it has reached its mature state. The arrows401in the young tree invoke the formation of different lineages of amygdala neurons402that form different branches of the tree, which then differentiate into populations403of neurons that control different aspects of medial amygdala regulated behaviors.404Cover image credits: Benjamin Toth/Getty Images; cover design by Joshua Corbin.",B,MAC_Bench/Cell/Cover/Trendsin Neurosciences/48_2.png,MAC_Bench/Cell/Cover/Trendsin Neurosciences/48_2.png,clip,48_2.txt,MAC_Bench/Cell/Cover/Trendsin Neurosciences/48_1.png,MAC_Bench/Cell/Cover/Trendsin Neurosciences/48_1.png,groundtruth,48_1.txt,MAC_Bench/Cell/Cover/Trendsin Neurosciences/39_9.png,MAC_Bench/Cell/Cover/Trendsin Neurosciences/39_9.png,ave_3,39_9.txt,MAC_Bench/Cell/Cover/Trendsin Neurosciences/44_4.png,MAC_Bench/Cell/Cover/Trendsin Neurosciences/44_4.png,ave_2,44_4.txt,test405NATURE BIOTECHNOLOGY,42_6,Which of the following options best describe the cover story?,"Measuring organellar sodium ions406A DNA nanodevice measuring organellar sodium ion levels in lysosomes of living cells. Zou et al. developed RatiNa for imaging intracellular Na+ at single-organelle resolution.407See Zou et al.408Image: Junyi Zou and Bruna Di Giacomo. Cover design: Erin Dewalt",B,MAC_Bench/Nature/Cover/NATURE BIOTECHNOLOGY/41_12.png,MAC_Bench/Nature/Cover/NATURE BIOTECHNOLOGY/41_12.png,clip,41_12.txt,MAC_Bench/Nature/Cover/NATURE BIOTECHNOLOGY/42_6.png,MAC_Bench/Nature/Cover/NATURE BIOTECHNOLOGY/42_6.png,groundtruth,42_6.txt,MAC_Bench/Nature/Cover/NATURE BIOTECHNOLOGY/41_9.png,MAC_Bench/Nature/Cover/NATURE BIOTECHNOLOGY/41_9.png,vitg,41_9.txt,MAC_Bench/Nature/Cover/NATURE BIOTECHNOLOGY/40_1.png,MAC_Bench/Nature/Cover/NATURE BIOTECHNOLOGY/40_1.png,vith,40_1.txt,train409Journal of the American Chemical Society,2024_32,Which of the following options best describe the cover story?,"An enzyme-cored spherical nucleic acid nanoplatform (CAT-ecSNA-Cu) used to deliver copper ions for cuproptosis was obtained based on enzyme–nucleic acid coupling and rolling circle amplification techniques. This strategy of enhancing cuproptosis-mediated anti-tumor immune responses by alleviating hypoxia promotes the activation of effector T cells, ultimately leading to long-term immunity against cancer. View the article.",C,MAC_Bench/ACS/Cover/Journal of the American Chemical Society/2023_28.png,MAC_Bench/ACS/Cover/Journal of the American Chemical Society/2023_28.png,vith,2023_28.txt,MAC_Bench/ACS/Cover/Journal of the American Chemical Society/2019_36.png,MAC_Bench/ACS/Cover/Journal of the American Chemical Society/2019_36.png,ave_2,2019_36.txt,MAC_Bench/ACS/Cover/Journal of the American Chemical Society/2024_32.png,MAC_Bench/ACS/Cover/Journal of the American Chemical Society/2024_32.png,groundtruth,2024_32.txt,MAC_Bench/ACS/Cover/Journal of the American Chemical Society/2024_17.png,MAC_Bench/ACS/Cover/Journal of the American Chemical Society/2024_17.png,clip,2024_17.txt,train410Trends in Chemistry,7_2,Which of the following options best describe the cover story?,"Polyoxovanadates (POVs) are a versatile class of metal-oxido clusters411with excellent solution, redox and thermal stability, and are particularly noted for412binding413to various peptide and protein targets with various therapeutic outcomes. In their414Forum article in this issue, Merlino and co-workers discuss recent data on the structural415features and binding mechanisms of POVs with proteins, to help better elucidate416structure-property-function correlation. These studies can aid the development of417new418POVs, help to better understand their biological action, suggest new uses for known419structures and break into wider fields like biohybrid materials and energy process420engineering.421Cover image credit: Prof. Antonello Merlino",A,MAC_Bench/Cell/Cover/Trends in Chemistry/7_2.png,MAC_Bench/Cell/Cover/Trends in Chemistry/7_2.png,groundtruth,7_2.txt,MAC_Bench/Cell/Cover/Trends in Chemistry/7_1.png,MAC_Bench/Cell/Cover/Trends in Chemistry/7_1.png,clip,7_1.txt,MAC_Bench/Cell/Cover/Trends in Chemistry/3_3.png,MAC_Bench/Cell/Cover/Trends in Chemistry/3_3.png,ave_3,3_3.txt,MAC_Bench/Cell/Cover/Trends in Chemistry/5_12.png,MAC_Bench/Cell/Cover/Trends in Chemistry/5_12.png,ave_2,5_12.txt,val422Cell Reports,43_12,Which of the following options best describe the cover story?,"On the cover: Spring represents a critical period of growth analogous to the critical423period for ocular dominance (OD) plasticity. The image depicts mice using vision to424hunt crickets under a fused tree crown representing the superior colliculus (SC).425In this issue, Hu and Chen et al. find that the critical period for OD plasticity in the mouse SC is independent of426the primary visual cortex and requires NMDA receptors. Concept and artwork: Xuefeng427Shi and Yanbing Shi.",C,MAC_Bench/Cell/Cover/Cell Reports/41_10.png,MAC_Bench/Cell/Cover/Cell Reports/41_10.png,vith,41_10.txt,MAC_Bench/Cell/Cover/Cell Reports/40_5.png,MAC_Bench/Cell/Cover/Cell Reports/40_5.png,vitg,40_5.txt,MAC_Bench/Cell/Cover/Cell Reports/43_12.png,MAC_Bench/Cell/Cover/Cell Reports/43_12.png,groundtruth,43_12.txt,MAC_Bench/Cell/Cover/Cell Reports/42_5.png,MAC_Bench/Cell/Cover/Cell Reports/42_5.png,clip,42_5.txt,train428ACS Applied Polymer Materials,2024_1,Which of the following options best describe the cover story?,"The gas separation (CO2 and methane) by a polymeric membrane with xanthene units and phenyl functional groups is shown. The circle shows the application of the modified membranes in electrochemical devices (fuel cells). The image background was created with Canvas, and the combustion cell was created with Gemini (Google).",C,MAC_Bench/ACS/Cover/ACS Applied Polymer Materials/2024_11.png,MAC_Bench/ACS/Cover/ACS Applied Polymer Materials/2024_11.png,ave_2,2024_11.txt,MAC_Bench/ACS/Cover/ACS Applied Polymer Materials/2022_4.png,MAC_Bench/ACS/Cover/ACS Applied Polymer Materials/2022_4.png,clip,2022_4.txt,MAC_Bench/ACS/Cover/ACS Applied Polymer Materials/2024_1.png,MAC_Bench/ACS/Cover/ACS Applied Polymer Materials/2024_1.png,groundtruth,2024_1.txt,MAC_Bench/ACS/Cover/ACS Applied Polymer Materials/2022_3.png,MAC_Bench/ACS/Cover/ACS Applied Polymer Materials/2022_3.png,ave_3,2022_3.txt,test429Nature Catalysis,7_8,Which of the following options best describe the cover story?,"Bias-free ammonia430In their work, Ji-Wook Jang and colleagues couple an efficient lead halide perovskite photocathode for nitrate reduction to a glycerol oxidation anode for bias-free ammonia production with a photocurrent density greater than 20 mA cm–2.431See Tayyebi et al.432Image: CUBE3D Graphic / Younghee Lee. Cover design: Alex Whitworth",A,MAC_Bench/Nature/Cover/Nature Catalysis/7_8.png,MAC_Bench/Nature/Cover/Nature Catalysis/7_8.png,groundtruth,7_8.txt,MAC_Bench/Nature/Cover/Nature Catalysis/7_6.png,MAC_Bench/Nature/Cover/Nature Catalysis/7_6.png,vith,7_6.txt,MAC_Bench/Nature/Cover/Nature Catalysis/5_12.png,MAC_Bench/Nature/Cover/Nature Catalysis/5_12.png,vitg,5_12.txt,MAC_Bench/Nature/Cover/Nature Catalysis/4_1.png,MAC_Bench/Nature/Cover/Nature Catalysis/4_1.png,clip,4_1.txt,train433Molecular Pharmaceutics,2024_4,Which of the following options best describe the cover story?,"The cover shows a novel therapeutic fusion protein that occurs as a homodimer. One monomer is colored according to the hydrogen exchange results, and the other monomer is colored according to the computational modeling results, both performed to understand the sites responsible for reversible self-association. The methodologies are indicated schematically, and the dual-colored dimer indicates the symbiosis of these methodologies.",C,MAC_Bench/ACS/Cover/Molecular Pharmaceutics/2024_8.png,MAC_Bench/ACS/Cover/Molecular Pharmaceutics/2024_8.png,vith,2024_8.txt,MAC_Bench/ACS/Cover/Molecular Pharmaceutics/2024_11.png,MAC_Bench/ACS/Cover/Molecular Pharmaceutics/2024_11.png,clip,2024_11.txt,MAC_Bench/ACS/Cover/Molecular Pharmaceutics/2024_4.png,MAC_Bench/ACS/Cover/Molecular Pharmaceutics/2024_4.png,groundtruth,2024_4.txt,MAC_Bench/ACS/Cover/Molecular Pharmaceutics/2025_2.png,MAC_Bench/ACS/Cover/Molecular Pharmaceutics/2025_2.png,vitg,2025_2.txt,train434Precision Chemistry,2024_1,Which of the following options best describe the cover story?,Cover illustrates nanometer-thick collector films of lithium batteries relying on a closely packed crossed-lamellar structure for excellent damage resistance.,D,MAC_Bench/ACS/Cover/Precision Chemistry/2024_3.png,MAC_Bench/ACS/Cover/Precision Chemistry/2024_3.png,vitg,2024_3.txt,MAC_Bench/ACS/Cover/Precision Chemistry/2023_1.png,MAC_Bench/ACS/Cover/Precision Chemistry/2023_1.png,clip,2023_1.txt,MAC_Bench/ACS/Cover/Precision Chemistry/2023_2.png,MAC_Bench/ACS/Cover/Precision Chemistry/2023_2.png,ave_2,2023_2.txt,MAC_Bench/ACS/Cover/Precision Chemistry/2024_1.png,MAC_Bench/ACS/Cover/Precision Chemistry/2024_1.png,groundtruth,2024_1.txt,test435NATURE REVIEWS GENETICS,25_11,Which of the following options best describe the cover story?,"Inspired by the Review on p83.436Cover design: Patrick Morgan.",D,MAC_Bench/Nature/Cover/NATURE REVIEWS GENETICS/24_12.png,MAC_Bench/Nature/Cover/NATURE REVIEWS GENETICS/24_12.png,clip,24_12.txt,MAC_Bench/Nature/Cover/NATURE REVIEWS GENETICS/25_7.png,MAC_Bench/Nature/Cover/NATURE REVIEWS GENETICS/25_7.png,vith,25_7.txt,MAC_Bench/Nature/Cover/NATURE REVIEWS GENETICS/25_10.png,MAC_Bench/Nature/Cover/NATURE REVIEWS GENETICS/25_10.png,vitg,25_10.txt,MAC_Bench/Nature/Cover/NATURE REVIEWS GENETICS/25_11.png,MAC_Bench/Nature/Cover/NATURE REVIEWS GENETICS/25_11.png,groundtruth,25_11.txt,val437NATURE REVIEWS DRUG DISCOVERY,23_1,Which of the following options best describe the cover story?,"Targeting the TNF and TNFR superfamilies, inspired by the Review on p939.438Cover design: S. Harris",C,MAC_Bench/Nature/Cover/NATURE REVIEWS DRUG DISCOVERY/22_2.png,MAC_Bench/Nature/Cover/NATURE REVIEWS DRUG DISCOVERY/22_2.png,ave_3,22_2.txt,MAC_Bench/Nature/Cover/NATURE REVIEWS DRUG DISCOVERY/23_11.png,MAC_Bench/Nature/Cover/NATURE REVIEWS DRUG DISCOVERY/23_11.png,ave_2,23_11.txt,MAC_Bench/Nature/Cover/NATURE REVIEWS DRUG DISCOVERY/23_1.png,MAC_Bench/Nature/Cover/NATURE REVIEWS DRUG DISCOVERY/23_1.png,groundtruth,23_1.txt,MAC_Bench/Nature/Cover/NATURE REVIEWS DRUG DISCOVERY/22_1.png,MAC_Bench/Nature/Cover/NATURE REVIEWS DRUG DISCOVERY/22_1.png,clip,22_1.txt,train439Science Signaling,2007_394,Which of the following options best describe the cover story?,"COVER This week's Focus Issue, published to complement the Science Special Issue on Undergraduate Education, contains an Editorial Guide as well as three Teaching Resources and the inaugural article for the new STKE Journal Club. [Classroom Image: Jupiter Images]",B,MAC_Bench/Science/Cover/Science Signaling/2007_408.png,MAC_Bench/Science/Cover/Science Signaling/2007_408.png,vith,2007_408.txt,MAC_Bench/Science/Cover/Science Signaling/2007_394.png,MAC_Bench/Science/Cover/Science Signaling/2007_394.png,groundtruth,2007_394.txt,MAC_Bench/Science/Cover/Science Signaling/2007_406.png,MAC_Bench/Science/Cover/Science Signaling/2007_406.png,clip,2007_406.txt,MAC_Bench/Science/Cover/Science Signaling/2007_380.png,MAC_Bench/Science/Cover/Science Signaling/2007_380.png,ave_2,2007_380.txt,train440Caner Cell,42_12,Which of the following options best describe the cover story?,"On the cover: Routy et al. review the microbiota research in the context of melanoma. The cover image demonstrates441the interplay between melanoma cancer cells and microbiota visually. An intricate442network of lines creates connections that symbolize the link between intestinal bacteria443and melanoma, highlighting the recent research included in the content, visually showcasing444the intricate relationship between the two. Image credit: Simon Rohlen, known as KEF!.",A,MAC_Bench/Cell/Cover/Caner Cell/42_12.png,MAC_Bench/Cell/Cover/Caner Cell/42_12.png,groundtruth,42_12.txt,MAC_Bench/Cell/Cover/Caner Cell/40_10.png,MAC_Bench/Cell/Cover/Caner Cell/40_10.png,vith,40_10.txt,MAC_Bench/Cell/Cover/Caner Cell/42_11.png,MAC_Bench/Cell/Cover/Caner Cell/42_11.png,clip,42_11.txt,MAC_Bench/Cell/Cover/Caner Cell/37_1.png,MAC_Bench/Cell/Cover/Caner Cell/37_1.png,vitg,37_1.txt,train445Nature Cell Biology,26_11,Which of the following options best describe the cover story?,"Human embryonic arrest446Single-cell multi-omics of arrested human embryos reveal that cytoskeletal defects cause embryonic arrest characterized by zygotic genome activation.447See Li et al.448Image: Lin Li and Teng Wang, Southern Medical University. Cover Design: Lauren Heslop",D,MAC_Bench/Nature/Cover/Nature Cell Biology/25_2.png,MAC_Bench/Nature/Cover/Nature Cell Biology/25_2.png,vith,25_2.txt,MAC_Bench/Nature/Cover/Nature Cell Biology/24_4.png,MAC_Bench/Nature/Cover/Nature Cell Biology/24_4.png,vitg,24_4.txt,MAC_Bench/Nature/Cover/Nature Cell Biology/26_9.png,MAC_Bench/Nature/Cover/Nature Cell Biology/26_9.png,clip,26_9.txt,MAC_Bench/Nature/Cover/Nature Cell Biology/26_11.png,MAC_Bench/Nature/Cover/Nature Cell Biology/26_11.png,groundtruth,26_11.txt,train449ACS Materials Letters,2024_6,Which of the following options best describe the cover story?,"Ultra-pure organic crystals do not display long-lived emission and, hence, can be perceived as essentially dark 3D frameworks. The review highlights that phosphorescence within these dark frameworks can be only achieved if tiny amounts of impurities are added. The impurities act as exciton traps and enable long-lived emission.",D,MAC_Bench/ACS/Cover/ACS Materials Letters/2024_7.png,MAC_Bench/ACS/Cover/ACS Materials Letters/2024_7.png,ave_3,2024_7.txt,MAC_Bench/ACS/Cover/ACS Materials Letters/2020_12.png,MAC_Bench/ACS/Cover/ACS Materials Letters/2020_12.png,clip,2020_12.txt,MAC_Bench/ACS/Cover/ACS Materials Letters/2024_10.png,MAC_Bench/ACS/Cover/ACS Materials Letters/2024_10.png,vitg,2024_10.txt,MAC_Bench/ACS/Cover/ACS Materials Letters/2024_6.png,MAC_Bench/ACS/Cover/ACS Materials Letters/2024_6.png,groundtruth,2024_6.txt,train450ACS Materials Au,2025_1,Which of the following options best describe the cover story?,"Due to its unique properties, microneedles are a potential game-changer in advanced healthcare with a focus on drug delivery and diagnosis. Recently, the focus has been on developing new technologies for fabricating microneedles with improved performance. AI was used in the creation of the cover image.",C,MAC_Bench/ACS/Cover/ACS Materials Au/2023_4.png,MAC_Bench/ACS/Cover/ACS Materials Au/2023_4.png,clip,2023_4.txt,MAC_Bench/ACS/Cover/ACS Materials Au/2024_3.png,MAC_Bench/ACS/Cover/ACS Materials Au/2024_3.png,ave_1,2024_3.txt,MAC_Bench/ACS/Cover/ACS Materials Au/2025_1.png,MAC_Bench/ACS/Cover/ACS Materials Au/2025_1.png,groundtruth,2025_1.txt,MAC_Bench/ACS/Cover/ACS Materials Au/2024_4.png,MAC_Bench/ACS/Cover/ACS Materials Au/2024_4.png,vitg,2024_4.txt,val451Nature Geoscience,17_1,Which of the following options best describe the cover story?,"The future of deep ocean drilling452The recent decommissioning of the JOIDES Resolution vessel run by the International Ocean Drilling Program presents a challenge for research reliant on deep-ocean drilling. The image shows the ship’s drilling derrick behind pipe racks involved in the collection of deep-sea sediment cores during International Ocean Discovery Program Expedition 403 to the Fram Strait during the summer of 2024.453See Q&A.454Image: Thomas Ronge, IODP JRSO. Cover design: Alex Wing",B,MAC_Bench/Nature/Cover/Nature Geoscience/13_6.png,MAC_Bench/Nature/Cover/Nature Geoscience/13_6.png,vitg,13_6.txt,MAC_Bench/Nature/Cover/Nature Geoscience/17_1.png,MAC_Bench/Nature/Cover/Nature Geoscience/17_1.png,groundtruth,17_1.txt,MAC_Bench/Nature/Cover/Nature Geoscience/14_7.png,MAC_Bench/Nature/Cover/Nature Geoscience/14_7.png,clip,14_7.txt,MAC_Bench/Nature/Cover/Nature Geoscience/17_11.png,MAC_Bench/Nature/Cover/Nature Geoscience/17_11.png,vith,17_11.txt,train455Nature Reviews Nephrology,20_5,Which of the following options best describe the cover story?,"Post-translational modifications, inspired by the Review on p495.456Cover design: Lara Crow",A,MAC_Bench/Nature/Cover/Nature Reviews Nephrology/20_5.png,MAC_Bench/Nature/Cover/Nature Reviews Nephrology/20_5.png,groundtruth,20_5.txt,MAC_Bench/Nature/Cover/Nature Reviews Nephrology/20_10.png,MAC_Bench/Nature/Cover/Nature Reviews Nephrology/20_10.png,ave_3,20_10.txt,MAC_Bench/Nature/Cover/Nature Reviews Nephrology/20_2.png,MAC_Bench/Nature/Cover/Nature Reviews Nephrology/20_2.png,ave_2,20_2.txt,MAC_Bench/Nature/Cover/Nature Reviews Nephrology/20_6.png,MAC_Bench/Nature/Cover/Nature Reviews Nephrology/20_6.png,clip,20_6.txt,train457Science Immunology,9_94,Which of the following options best describe the cover story?,"ONLINE COVER Cultivating Memory B Cell Responses to a Plant-Based Vaccine. CoVLP (coronavirus virus-like particle) is a promising COVID-19 vaccine produced in the weed Nicotiana benthamiana. A squalene-based adjuvant, AS03, can enhance immune responses to CoVLP vaccination, but how AS03 affects memory B cell responses to CoVLP is unknown. Grigoryan et al. studied immune responses in healthy individuals who received two doses of CoVLP with or without AS03. They found that AS03 promoted the progressive maturation of memory B cell responses over time, leading to enhanced neutralization of SARS-CoV-2 and increased memory B cell breadth. This month’s cover illustration depicts a syringe containing a plant-based SARS-CoV-2 vaccine. Credit: N. Jessup/Science Immunology (syringe: C. Horz/Alamy Stock Vector)",D,MAC_Bench/Science/Cover/Science Immunology/8_86.png,MAC_Bench/Science/Cover/Science Immunology/8_86.png,vith,8_86.txt,MAC_Bench/Science/Cover/Science Immunology/9_92.png,MAC_Bench/Science/Cover/Science Immunology/9_92.png,clip,9_92.txt,MAC_Bench/Science/Cover/Science Immunology/9_93.png,MAC_Bench/Science/Cover/Science Immunology/9_93.png,vitg,9_93.txt,MAC_Bench/Science/Cover/Science Immunology/9_94.png,MAC_Bench/Science/Cover/Science Immunology/9_94.png,groundtruth,9_94.txt,train458Nature Aging,4_7,Which of the following options best describe the cover story?,"Stochasticity in epigenetic clocks459In this issue, three studies examine the contribution of stochastic epigenetic changes to DNA methylation clocks. Tarkhov et al., Meyer et al. and Tong et al. take different approaches to addressing this question, and concur that stochasticity is involved in epigenetic aging. The cover, from Meyer et al., shows a Galton board, which is a device used to illustrate concepts of probability and stochasticity. At the top, a series of small balls are released, which follow a random path before landing in bins at the bottom. Over many trials, this stochastic process leads to the formation of a normal distributed shape. A clock is depicted within this shape to illustrate that a completely stochastic process can be used to construct aging clocks, consistent with a role of age-dependent increases in stochastic variation in epigenetic processes.460See Tarkhov et al., Meyer et al. & Tong et al.461Image: Maayan Visuals. Cover design: Lauren Heslop",B,MAC_Bench/Nature/Cover/Nature Aging/3_4.png,MAC_Bench/Nature/Cover/Nature Aging/3_4.png,vith,3_4.txt,MAC_Bench/Nature/Cover/Nature Aging/4_7.png,MAC_Bench/Nature/Cover/Nature Aging/4_7.png,groundtruth,4_7.txt,MAC_Bench/Nature/Cover/Nature Aging/2_7.png,MAC_Bench/Nature/Cover/Nature Aging/2_7.png,clip,2_7.txt,MAC_Bench/Nature/Cover/Nature Aging/4_11.png,MAC_Bench/Nature/Cover/Nature Aging/4_11.png,vitg,4_11.txt,test462Cell Reports,43_5,Which of the following options best describe the cover story?,"On the cover: The process of alternative polyadenylation is dynamically regulated463during development and cell fate determination. In this issue, Liu et al. determine the molecular mechanism by which the RNA-binding protein PQBP1 orchestrates464dynamic mRNA-3'UTR changes during neurogenesis. The cover depicts an ancient Chinese465mythical creature, the Vermilion Bird. The short tails represent the short 3'UTRs466in neural stem cells in contrast to the long tails representing extended 3'UTRs in467mature neurons. Concept and artwork: Zi Chao Zhang, Xian Liu, and Xinyu Wang.",A,MAC_Bench/Cell/Cover/Cell Reports/43_5.png,MAC_Bench/Cell/Cover/Cell Reports/43_5.png,groundtruth,43_5.txt,MAC_Bench/Cell/Cover/Cell Reports/38_4.png,MAC_Bench/Cell/Cover/Cell Reports/38_4.png,vitg,38_4.txt,MAC_Bench/Cell/Cover/Cell Reports/42_5.png,MAC_Bench/Cell/Cover/Cell Reports/42_5.png,clip,42_5.txt,MAC_Bench/Cell/Cover/Cell Reports/43_6.png,MAC_Bench/Cell/Cover/Cell Reports/43_6.png,vith,43_6.txt,train468Trends in Chemistry,6_12,Which of the following options best describe the cover story?,"Plastic upcycling is a strategy for treating plastic waste, not only to469remedy environmental pollution but also to provide tremendous resources for novel470advanced materials. In this issue, Lim and Nguyen discuss sustainable approaches471to upcycle plastics, converting them into useful chemicals and materials. The review472highlights green chemical catalysis and hybrid methods that integrate biocatalysis,473offering immense potential for valorizing waste plastics. Cover image credit: the474authors, who found joy in art design, in addition to their passion for valorizing475plastics.",C,MAC_Bench/Cell/Cover/Trends in Chemistry/6_10.png,MAC_Bench/Cell/Cover/Trends in Chemistry/6_10.png,clip,6_10.txt,MAC_Bench/Cell/Cover/Trends in Chemistry/5_12.png,MAC_Bench/Cell/Cover/Trends in Chemistry/5_12.png,vith,5_12.txt,MAC_Bench/Cell/Cover/Trends in Chemistry/6_12.png,MAC_Bench/Cell/Cover/Trends in Chemistry/6_12.png,groundtruth,6_12.txt,MAC_Bench/Cell/Cover/Trends in Chemistry/2_1.png,MAC_Bench/Cell/Cover/Trends in Chemistry/2_1.png,ave_3,2_1.txt,train476One Earth,7_10,Which of the following options best describe the cover story?,"On the cover: Clean water is vital to the health of our planet, yet increasing anthropogenic477pressures threaten this precious resource. Here, the graceful swirls of an algae bloom478reveal a water system imperiled by agricultural runoff, with consequences for biodiversity479and human health. Anton Petrus for Getty Images.",A,MAC_Bench/Cell/Cover/One Earth/7_10.png,MAC_Bench/Cell/Cover/One Earth/7_10.png,groundtruth,7_10.txt,MAC_Bench/Cell/Cover/One Earth/7_11.png,MAC_Bench/Cell/Cover/One Earth/7_11.png,clip,7_11.txt,MAC_Bench/Cell/Cover/One Earth/5_1.png,MAC_Bench/Cell/Cover/One Earth/5_1.png,vith,5_1.txt,MAC_Bench/Cell/Cover/One Earth/5_11.png,MAC_Bench/Cell/Cover/One Earth/5_11.png,vitg,5_11.txt,val480Nature Cancer,5_2,Which of the following options best describe the cover story?,"Charting tumor evolution with the Human Tumor Atlas Network481The Human Tumor Atlas Network explores tumor evolution in time and space by compiling integrative atlases of cellular, molecular and histological tumor features.482See Iglesia et al. , Zhu et al. and Esplin et al.483Image: Lilawa.com / Alamy Stock Photo. Cover design: Allen Beattie",C,MAC_Bench/Nature/Cover/Nature Cancer/2_9.png,MAC_Bench/Nature/Cover/Nature Cancer/2_9.png,clip,2_9.txt,MAC_Bench/Nature/Cover/Nature Cancer/3_6.png,MAC_Bench/Nature/Cover/Nature Cancer/3_6.png,vitg,3_6.txt,MAC_Bench/Nature/Cover/Nature Cancer/5_2.png,MAC_Bench/Nature/Cover/Nature Cancer/5_2.png,groundtruth,5_2.txt,MAC_Bench/Nature/Cover/Nature Cancer/1_9.png,MAC_Bench/Nature/Cover/Nature Cancer/1_9.png,vith,1_9.txt,val484The Journal of Physical Chemistry C,2025_2,Which of the following options best describe the cover story?,"The cover art depicts an isolated hydroxyl-bridged tricopper triangular complex being lifted from the kagomé lattice of herbertsmithite, illustrating how our new compound, CaCu(OH)3Cl, represents a chemically equivalent zero-dimensional analogue of this well studied quantum spin liquid candidate. View the article.",A,MAC_Bench/ACS/Cover/The Journal of Physical Chemistry C/2025_2.png,MAC_Bench/ACS/Cover/The Journal of Physical Chemistry C/2025_2.png,groundtruth,2025_2.txt,MAC_Bench/ACS/Cover/The Journal of Physical Chemistry C/2022_46.png,MAC_Bench/ACS/Cover/The Journal of Physical Chemistry C/2022_46.png,clip,2022_46.txt,MAC_Bench/ACS/Cover/The Journal of Physical Chemistry C/2024_35.png,MAC_Bench/ACS/Cover/The Journal of Physical Chemistry C/2024_35.png,vith,2024_35.txt,MAC_Bench/ACS/Cover/The Journal of Physical Chemistry C/2024_33.png,MAC_Bench/ACS/Cover/The Journal of Physical Chemistry C/2024_33.png,vitg,2024_33.txt,train485Molecular Therapy,32_15,Which of the following options best describe the cover story?,"On the cover: Pyroptosis is an inflammatory form of programmed cell death that occurs upon infection.486Kou and colleagues revealed that pyroptotic cells generate a new group of pyroptotic extracellular vesicles487(pyroEVs) and uncover the therapeutic effect of mesenchymal stem cell-derived pyroEVs488on sepsis. Specific expressed ASC can serve as a functional marker identifying exogenous489and endogenous pyroEVs and mediating the protective effect of pyroEV on B cells. In490this image, even the “fiery falling” pyroptotic cells will generate small nutrient491vesicles to protect the damaged host B cells during infection, thus rescuing sepsis.492Image credit: Suqian Qinyan Information Technology Co., LTD.",A,MAC_Bench/Cell/Cover/Molecular Therapy/32_15.png,MAC_Bench/Cell/Cover/Molecular Therapy/32_15.png,groundtruth,32_15.txt,MAC_Bench/Cell/Cover/Molecular Therapy/29_6.png,MAC_Bench/Cell/Cover/Molecular Therapy/29_6.png,clip,29_6.txt,MAC_Bench/Cell/Cover/Molecular Therapy/29_15.png,MAC_Bench/Cell/Cover/Molecular Therapy/29_15.png,ave_2,29_15.txt,MAC_Bench/Cell/Cover/Molecular Therapy/31_3.png,MAC_Bench/Cell/Cover/Molecular Therapy/31_3.png,vith,31_3.txt,train493Environmental Science & Technology,2025_4,Which of the following options best describe the cover story?,This cover art showcases efforts to monitor CO2 emissions through the effective integration of multiple satellite measurements. It highlights an independent method for tracking progress in climate change mitigation.,C,MAC_Bench/ACS/Cover/Environmental Science & Technology/2025_5.png,MAC_Bench/ACS/Cover/Environmental Science & Technology/2025_5.png,ave_1,2025_5.txt,MAC_Bench/ACS/Cover/Environmental Science & Technology/2022_23.png,MAC_Bench/ACS/Cover/Environmental Science & Technology/2022_23.png,vitg,2022_23.txt,MAC_Bench/ACS/Cover/Environmental Science & Technology/2025_4.png,MAC_Bench/ACS/Cover/Environmental Science & Technology/2025_4.png,groundtruth,2025_4.txt,MAC_Bench/ACS/Cover/Environmental Science & Technology/2024_49.png,MAC_Bench/ACS/Cover/Environmental Science & Technology/2024_49.png,clip,2024_49.txt,train494Matter,7_10,Which of the following options best describe the cover story?,"On the cover: To encapsulate the theme of our first annual Special Double Issue, we495invited two covers and split them across the middle (see this issue’s Editorial for the original, unaltered versions). Top: Conceptual design highlighting the critical496role of liquid metal in modulating the wetting behavior of lithium metal on solid-state497electrolyte (see Fu and colleagues). Inspiration was drawn from the technique of blending ink on xuan paper, which is498an essential step in the creation of traditional Chinese painting. The surface of499the solid-state electrolyte resembles the texture of xuan paper, exhibiting an intrinsic500lithiophobic character that impedes effective interface contact and promotes the growth501of dendrites. Bottom: One small step, one giant leap for biohybrid robots. We present502a biohybrid bipedal robot equipped with two legs and cultured skeletal muscle tissues503(see Takeuchi and colleagues). This integration of mechanical components with biological materials enables controlled504walking motions, including forward and stop motion, ultimately evolving towards the505subtle movements characteristic of human bipedal locomotion.",A,MAC_Bench/Cell/Cover/Matter/7_10.png,MAC_Bench/Cell/Cover/Matter/7_10.png,groundtruth,7_10.txt,MAC_Bench/Cell/Cover/Matter/7_2.png,MAC_Bench/Cell/Cover/Matter/7_2.png,clip,7_2.txt,MAC_Bench/Cell/Cover/Matter/6_7.png,MAC_Bench/Cell/Cover/Matter/6_7.png,vitg,6_7.txt,MAC_Bench/Cell/Cover/Matter/5_6.png,MAC_Bench/Cell/Cover/Matter/5_6.png,vith,5_6.txt,train506NATURE METHODS,21_8,Which of the following options best describe the cover story?,"Focus on methods for immunology507A scanning electron microscope image captures the dynamic interplay between a CD19-hexapod biomimetic antigen-presenting structure and an anti-CD19 CAR-T cell.508See Huang et al.509Image: Bozhi Tian, University of Chicago. Cover design: Thomas Phillips",D,MAC_Bench/Nature/Cover/NATURE METHODS/20_7.png,MAC_Bench/Nature/Cover/NATURE METHODS/20_7.png,clip,20_7.txt,MAC_Bench/Nature/Cover/NATURE METHODS/20_1.png,MAC_Bench/Nature/Cover/NATURE METHODS/20_1.png,ave_2,20_1.txt,MAC_Bench/Nature/Cover/NATURE METHODS/7_4.png,MAC_Bench/Nature/Cover/NATURE METHODS/7_4.png,vitg,7_4.txt,MAC_Bench/Nature/Cover/NATURE METHODS/21_8.png,MAC_Bench/Nature/Cover/NATURE METHODS/21_8.png,groundtruth,21_8.txt,val510ACS Applied Energy Materials,2025_1,Which of the following options best describe the cover story?,"Understanding the growth mechanism of Li dendrites near pits is essential for improving battery performance, contributing to greater safety and efficiency.",C,MAC_Bench/ACS/Cover/ACS Applied Energy Materials/2021_1.png,MAC_Bench/ACS/Cover/ACS Applied Energy Materials/2021_1.png,vith,2021_1.txt,MAC_Bench/ACS/Cover/ACS Applied Energy Materials/2019_9.png,MAC_Bench/ACS/Cover/ACS Applied Energy Materials/2019_9.png,vitg,2019_9.txt,MAC_Bench/ACS/Cover/ACS Applied Energy Materials/2025_1.png,MAC_Bench/ACS/Cover/ACS Applied Energy Materials/2025_1.png,groundtruth,2025_1.txt,MAC_Bench/ACS/Cover/ACS Applied Energy Materials/2019_8.png,MAC_Bench/ACS/Cover/ACS Applied Energy Materials/2019_8.png,clip,2019_8.txt,test511NATURE ENERGY,9_5,Which of the following options best describe the cover story?,"Disrupting gender norms512A just and equitable energy transition requires addressing historically embedded gender norms. Michael and Ahlborg shed light on the Solar Mamas programme in Zanzibar as an example for how locally led, contextually grounded energy interventions prioritizing care work and women’s knowledge may contribute to disrupting established norms.513See Michael and Ahlborg and Research Briefing514Image: Olga Timokhina, La Fabrika Films. Cover design: Thomas Phillips.",C,MAC_Bench/Nature/Cover/NATURE ENERGY/9_1.png,MAC_Bench/Nature/Cover/NATURE ENERGY/9_1.png,clip,9_1.txt,MAC_Bench/Nature/Cover/NATURE ENERGY/8_3.png,MAC_Bench/Nature/Cover/NATURE ENERGY/8_3.png,vitg,8_3.txt,MAC_Bench/Nature/Cover/NATURE ENERGY/9_5.png,MAC_Bench/Nature/Cover/NATURE ENERGY/9_5.png,groundtruth,9_5.txt,MAC_Bench/Nature/Cover/NATURE ENERGY/7_3.png,MAC_Bench/Nature/Cover/NATURE ENERGY/7_3.png,vith,7_3.txt,train515ACS Synthetic Biology,2024_12,Which of the following options best describe the cover story?,Shining the spotlight on gene editors: optically controlled Cas9 and Cre provide precise spatiotemporal control over gene editing. The review discusses the methods for engineering the optical control of these enzymes. Why light? Clinical benefits? Any limitations? The future? Read more to find out!,A,MAC_Bench/ACS/Cover/ACS Synthetic Biology/2024_12.png,MAC_Bench/ACS/Cover/ACS Synthetic Biology/2024_12.png,groundtruth,2024_12.txt,MAC_Bench/ACS/Cover/ACS Synthetic Biology/2016_12.png,MAC_Bench/ACS/Cover/ACS Synthetic Biology/2016_12.png,ave_3,2016_12.txt,MAC_Bench/ACS/Cover/ACS Synthetic Biology/2022_12.png,MAC_Bench/ACS/Cover/ACS Synthetic Biology/2022_12.png,ave_2,2022_12.txt,MAC_Bench/ACS/Cover/ACS Synthetic Biology/2022_11.png,MAC_Bench/ACS/Cover/ACS Synthetic Biology/2022_11.png,clip,2022_11.txt,train516ACS Sustainable Resource Management,2024_10,Which of the following options best describe the cover story?,"On the journal cover a degraded perovskite photovoltaic device is depicted in the back. The recent work of Bogachuk et al. demonstrates an effective end-of-life strategy to reuse part of the device and remanufacture such solar cells and modules via a novel thermally assisted mechanochemical approach, which strongly reduces their carbon footprint.",C,MAC_Bench/ACS/Cover/ACS Sustainable Resource Management/2024_9.png,MAC_Bench/ACS/Cover/ACS Sustainable Resource Management/2024_9.png,clip,2024_9.txt,MAC_Bench/ACS/Cover/ACS Sustainable Resource Management/2024_7.png,MAC_Bench/ACS/Cover/ACS Sustainable Resource Management/2024_7.png,ave_2,2024_7.txt,MAC_Bench/ACS/Cover/ACS Sustainable Resource Management/2024_10.png,MAC_Bench/ACS/Cover/ACS Sustainable Resource Management/2024_10.png,groundtruth,2024_10.txt,MAC_Bench/ACS/Cover/ACS Sustainable Resource Management/2024_12.png,MAC_Bench/ACS/Cover/ACS Sustainable Resource Management/2024_12.png,ave_3,2024_12.txt,val517Nature Reviews Nephrology,20_2,Which of the following options best describe the cover story?,"Drug repurposing, inspired by the Review on p707.518Cover design: Lara Crow",D,MAC_Bench/Nature/Cover/Nature Reviews Nephrology/20_3.png,MAC_Bench/Nature/Cover/Nature Reviews Nephrology/20_3.png,vitg,20_3.txt,MAC_Bench/Nature/Cover/Nature Reviews Nephrology/19_1.png,MAC_Bench/Nature/Cover/Nature Reviews Nephrology/19_1.png,clip,19_1.txt,MAC_Bench/Nature/Cover/Nature Reviews Nephrology/19_2.png,MAC_Bench/Nature/Cover/Nature Reviews Nephrology/19_2.png,ave_2,19_2.txt,MAC_Bench/Nature/Cover/Nature Reviews Nephrology/20_2.png,MAC_Bench/Nature/Cover/Nature Reviews Nephrology/20_2.png,groundtruth,20_2.txt,val519CELL RESEARCH,34_1,Which of the following options best describe the cover story?,"This image depicts a story of a powerful AI comet merging in the life science universe. The information in millions of single-cell transcriptomes was distilled to create a large foundation model named GeneCompass, which uses cutting-edge foundation model AI technologies to decipher universal gene regulatory mechanisms and shows tremendous potential for accelerating advancements in life science research.See page 830–845 by Xiaodong Yang et al. for details.",C,MAC_Bench/Nature/Cover/CELL RESEARCH/34_4.png,MAC_Bench/Nature/Cover/CELL RESEARCH/34_4.png,clip,34_4.txt,MAC_Bench/Nature/Cover/CELL RESEARCH/31_1.png,MAC_Bench/Nature/Cover/CELL RESEARCH/31_1.png,ave_2,31_1.txt,MAC_Bench/Nature/Cover/CELL RESEARCH/34_1.png,MAC_Bench/Nature/Cover/CELL RESEARCH/34_1.png,groundtruth,34_1.txt,MAC_Bench/Nature/Cover/CELL RESEARCH/34_11.png,MAC_Bench/Nature/Cover/CELL RESEARCH/34_11.png,vitg,34_11.txt,val520NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY,22_2,Which of the following options best describe the cover story?,"Diet and intestinal stem cells, inspired by the Review on p23521Cover design: Neil Smith",A,MAC_Bench/Nature/Cover/NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY/22_2.png,MAC_Bench/Nature/Cover/NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY/22_2.png,groundtruth,22_2.txt,MAC_Bench/Nature/Cover/NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY/21_11.png,MAC_Bench/Nature/Cover/NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY/21_11.png,ave_3,21_11.txt,MAC_Bench/Nature/Cover/NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY/20_11.png,MAC_Bench/Nature/Cover/NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY/20_11.png,ave_2,20_11.txt,MAC_Bench/Nature/Cover/NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY/22_1.png,MAC_Bench/Nature/Cover/NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY/22_1.png,clip,22_1.txt,train522Nature Ecology & Evolution,8_8,Which of the following options best describe the cover story?,"Social transmission523Social behaviour among wild wood mice (Apodemus sylvaticus) provides a way to share microbes. Their social networks are an important transmission route for anaerobic gut microbes, whereas more oxygen-tolerant gut microbes spread through shared environments instead.524See Raulo et al525Image: Roy and Marie Battell. Cover Design: Allen Beattie.",D,MAC_Bench/Nature/Cover/Nature Ecology & Evolution/7_4.png,MAC_Bench/Nature/Cover/Nature Ecology & Evolution/7_4.png,vith,7_4.txt,MAC_Bench/Nature/Cover/Nature Ecology & Evolution/4_11.png,MAC_Bench/Nature/Cover/Nature Ecology & Evolution/4_11.png,clip,4_11.txt,MAC_Bench/Nature/Cover/Nature Ecology & Evolution/1_1.png,MAC_Bench/Nature/Cover/Nature Ecology & Evolution/1_1.png,vitg,1_1.txt,MAC_Bench/Nature/Cover/Nature Ecology & Evolution/8_8.png,MAC_Bench/Nature/Cover/Nature Ecology & Evolution/8_8.png,groundtruth,8_8.txt,train526ACS Chemical Biology,2025_1,Which of the following options best describe the cover story?,"Small fragment molecules are vital for exploring receptor pharmacology and serve as building blocks for drug development. Advanced NMR techniques enable in situ identification of small-molecule ligands targeting receptors within native cell membranes, expanding drug discovery strategies.",A,MAC_Bench/ACS/Cover/ACS Chemical Biology/2025_1.png,MAC_Bench/ACS/Cover/ACS Chemical Biology/2025_1.png,groundtruth,2025_1.txt,MAC_Bench/ACS/Cover/ACS Chemical Biology/2022_11.png,MAC_Bench/ACS/Cover/ACS Chemical Biology/2022_11.png,clip,2022_11.txt,MAC_Bench/ACS/Cover/ACS Chemical Biology/2021_5.png,MAC_Bench/ACS/Cover/ACS Chemical Biology/2021_5.png,ave_2,2021_5.txt,MAC_Bench/ACS/Cover/ACS Chemical Biology/2022_6.png,MAC_Bench/ACS/Cover/ACS Chemical Biology/2022_6.png,vith,2022_6.txt,train527ACS Applied Bio Materials,2025_2,Which of the following options best describe the cover story?,This cover art describes an antibacterial hydrogel material covering wounds on the skin. The hydrogel hosts extracellular vesicles derived from mint leaves. These extracellular vesicles kill the bacteria in the wound site and promote wound healing. The cover art is made with Adobe Firefly.,C,MAC_Bench/ACS/Cover/ACS Applied Bio Materials/2024_7.png,MAC_Bench/ACS/Cover/ACS Applied Bio Materials/2024_7.png,clip,2024_7.txt,MAC_Bench/ACS/Cover/ACS Applied Bio Materials/2023_2.png,MAC_Bench/ACS/Cover/ACS Applied Bio Materials/2023_2.png,vitg,2023_2.txt,MAC_Bench/ACS/Cover/ACS Applied Bio Materials/2025_2.png,MAC_Bench/ACS/Cover/ACS Applied Bio Materials/2025_2.png,groundtruth,2025_2.txt,MAC_Bench/ACS/Cover/ACS Applied Bio Materials/2023_12.png,MAC_Bench/ACS/Cover/ACS Applied Bio Materials/2023_12.png,vith,2023_12.txt,train528Nature Reviews Bioengineering,3_1,Which of the following options best describe the cover story?,"Stem cell-based embryo models can recapitulate symmetry breaking, pattern formation and tissue morphogenesis during early development. To control and guide their in vivo-like cellular organization and architecture, bioengineering approaches can be applied, including biomaterials, additive manufacturing, microphysiological models and synthetic biology. See Xufeng Xue et al.529Cover image: Simon Bradbrook",C,MAC_Bench/Nature/Cover/Nature Reviews Bioengineering/2_11.png,MAC_Bench/Nature/Cover/Nature Reviews Bioengineering/2_11.png,clip,2_11.txt,MAC_Bench/Nature/Cover/Nature Reviews Bioengineering/1_12.png,MAC_Bench/Nature/Cover/Nature Reviews Bioengineering/1_12.png,vith,1_12.txt,MAC_Bench/Nature/Cover/Nature Reviews Bioengineering/3_1.png,MAC_Bench/Nature/Cover/Nature Reviews Bioengineering/3_1.png,groundtruth,3_1.txt,MAC_Bench/Nature/Cover/Nature Reviews Bioengineering/1_10.png,MAC_Bench/Nature/Cover/Nature Reviews Bioengineering/1_10.png,vitg,1_10.txt,train530Nature Reviews Neurology,20_2,Which of the following options best describe the cover story?,"Systemic support for the brain, inspired by the Review on p647.531Cover design: Amie Fernandez",D,MAC_Bench/Nature/Cover/Nature Reviews Neurology/20_4.png,MAC_Bench/Nature/Cover/Nature Reviews Neurology/20_4.png,vitg,20_4.txt,MAC_Bench/Nature/Cover/Nature Reviews Neurology/20_12.png,MAC_Bench/Nature/Cover/Nature Reviews Neurology/20_12.png,clip,20_12.txt,MAC_Bench/Nature/Cover/Nature Reviews Neurology/19_2.png,MAC_Bench/Nature/Cover/Nature Reviews Neurology/19_2.png,ave_3,19_2.txt,MAC_Bench/Nature/Cover/Nature Reviews Neurology/20_2.png,MAC_Bench/Nature/Cover/Nature Reviews Neurology/20_2.png,groundtruth,20_2.txt,train532Bioconjugate Chemistry,2024_6,Which of the following options best describe the cover story?,"A norbornene-containing analogue of farnesyl diphosphate increases the utility of prenyltransferase-catalyzed protein labeling. In one application, a unique subset of prenylated proteins was observed via proteomics. In another",B,MAC_Bench/ACS/Cover/Bioconjugate Chemistry/2023_6.png,MAC_Bench/ACS/Cover/Bioconjugate Chemistry/2023_6.png,vitg,2023_6.txt,MAC_Bench/ACS/Cover/Bioconjugate Chemistry/2024_6.png,MAC_Bench/ACS/Cover/Bioconjugate Chemistry/2024_6.png,groundtruth,2024_6.txt,MAC_Bench/ACS/Cover/Bioconjugate Chemistry/2020_5.png,MAC_Bench/ACS/Cover/Bioconjugate Chemistry/2020_5.png,clip,2020_5.txt,MAC_Bench/ACS/Cover/Bioconjugate Chemistry/2024_1.png,MAC_Bench/ACS/Cover/Bioconjugate Chemistry/2024_1.png,vith,2024_1.txt,train533Cell Reports Physical Science,5_11,Which of the following options best describe the cover story?,"On the cover: Week after week, technology companies unveil new AI tools that increasingly534resemble humans. The activity of humans and scientists is becoming more and more influenced535by AI. Fazio et al. propose a multiscale data-driven strategy for hierarchical physical phenomena that536keeps scientists as main players. Explicit analytical relationships to be easily interpreted537are deduced, enabling a continuous interaction between data modelling and scientific538knowledge. Spider silk is considered as an explicit proof of concept. The cover graphic539was designed by Federica Fazio.",D,MAC_Bench/Cell/Cover/Cell Reports Physical Science/3_2.png,MAC_Bench/Cell/Cover/Cell Reports Physical Science/3_2.png,clip,3_2.txt,MAC_Bench/Cell/Cover/Cell Reports Physical Science/5_8.png,MAC_Bench/Cell/Cover/Cell Reports Physical Science/5_8.png,vith,5_8.txt,MAC_Bench/Cell/Cover/Cell Reports Physical Science/4_12.png,MAC_Bench/Cell/Cover/Cell Reports Physical Science/4_12.png,vitg,4_12.txt,MAC_Bench/Cell/Cover/Cell Reports Physical Science/5_11.png,MAC_Bench/Cell/Cover/Cell Reports Physical Science/5_11.png,groundtruth,5_11.txt,val540The Journal of Physical Chemistry B,2025_2,Which of the following options best describe the cover story?,"The two-photon absorption of the Green Fluorescent Protein is intrinsically enhanced when utilizing quantum light. The classical and entangled two-photon absorption strengths can be differentially modulated by the protein, enabling precise control over the outcome through adjustments in its local electric field induced by a single amino acid substitution. The image is an artistic representation of the protein absorbing entangled light. Part of the image was generated by artificial intelligence using Kandinsky 2.2. View the article.",B,MAC_Bench/ACS/Cover/The Journal of Physical Chemistry B/2022_29.png,MAC_Bench/ACS/Cover/The Journal of Physical Chemistry B/2022_29.png,vith,2022_29.txt,MAC_Bench/ACS/Cover/The Journal of Physical Chemistry B/2025_2.png,MAC_Bench/ACS/Cover/The Journal of Physical Chemistry B/2025_2.png,groundtruth,2025_2.txt,MAC_Bench/ACS/Cover/The Journal of Physical Chemistry B/2022_20.png,MAC_Bench/ACS/Cover/The Journal of Physical Chemistry B/2022_20.png,vitg,2022_20.txt,MAC_Bench/ACS/Cover/The Journal of Physical Chemistry B/2024_34.png,MAC_Bench/ACS/Cover/The Journal of Physical Chemistry B/2024_34.png,clip,2024_34.txt,train541BDJ,237_3,Which of the following options best describe the cover story?,"In this issue542This issue features articles on peri-implantitis, implant-supported overdentures, and AI in oral medicine.543 544Cover image: From 2021. Our 2021 cover series recognising the strains placed on dental professionals in the wake of the coronavirus pandemic aimed to focus attention not only on the crossinfection control measures but also on the consequent human pressures. The cover on this issue (incorporating Vol 230 Issue 5, 12 March 2021) adds visual clues to some of the challenges we experienced in publishing during the pandemic.545©Tim Marrs, incorporating original photography by Filip Gierlinski",C,MAC_Bench/Nature/Cover/BDJ/235_4.png,MAC_Bench/Nature/Cover/BDJ/235_4.png,ave_3,235_4.txt,MAC_Bench/Nature/Cover/BDJ/237_6.png,MAC_Bench/Nature/Cover/BDJ/237_6.png,clip,237_6.txt,MAC_Bench/Nature/Cover/BDJ/237_3.png,MAC_Bench/Nature/Cover/BDJ/237_3.png,groundtruth,237_3.txt,MAC_Bench/Nature/Cover/BDJ/237_10.png,MAC_Bench/Nature/Cover/BDJ/237_10.png,vitg,237_10.txt,train546Journal of the American Chemical Society,2024_43,Which of the following options best describe the cover story?,"This study reveals two distinct pathways to synthesize hydrogels from random copolypeptides through ring-opening polymerization of N-carboxyanhydrides: rapid assembly into elongated fibril networks and the formation of robust fibril clusters, shaping the future of synthetic, biomimetic hydrogel design with custom-designed properties.",D,MAC_Bench/ACS/Cover/Journal of the American Chemical Society/2018_51.png,MAC_Bench/ACS/Cover/Journal of the American Chemical Society/2018_51.png,vith,2018_51.txt,MAC_Bench/ACS/Cover/Journal of the American Chemical Society/2021_36.png,MAC_Bench/ACS/Cover/Journal of the American Chemical Society/2021_36.png,vitg,2021_36.txt,MAC_Bench/ACS/Cover/Journal of the American Chemical Society/2021_5.png,MAC_Bench/ACS/Cover/Journal of the American Chemical Society/2021_5.png,clip,2021_5.txt,MAC_Bench/ACS/Cover/Journal of the American Chemical Society/2024_43.png,MAC_Bench/ACS/Cover/Journal of the American Chemical Society/2024_43.png,groundtruth,2024_43.txt,train547Nature Water,2_7,Which of the following options best describe the cover story?,"Freshwater snow with a touch of microplastic548From an ecosystem services point of view, microplastics can have both direct and indirect impacts on natural systems. The artwork on the cover depicts the interactions between microplastics and freshwater snow, illustrating their aggregation in water, a pivotal process shaping their respective settling rates. By unravelling these dynamics, it is possible to gain deeper insights into the fate of microplastics and their consequential impact on natural cycles.549See Parrella et al.550Image: Thomas Kast. Cover design: Debbie Maizels",D,MAC_Bench/Nature/Cover/Nature Water/1_8.png,MAC_Bench/Nature/Cover/Nature Water/1_8.png,ave_2,1_8.txt,MAC_Bench/Nature/Cover/Nature Water/2_1.png,MAC_Bench/Nature/Cover/Nature Water/2_1.png,clip,2_1.txt,MAC_Bench/Nature/Cover/Nature Water/1_2.png,MAC_Bench/Nature/Cover/Nature Water/1_2.png,vith,1_2.txt,MAC_Bench/Nature/Cover/Nature Water/2_7.png,MAC_Bench/Nature/Cover/Nature Water/2_7.png,groundtruth,2_7.txt,val551ACS Catalysis,2024_9,Which of the following options best describe the cover story?,"Out of two possible activation modes to provide two sulfonyl radicals, mechanistic studies rule out an energy transfer mechanism and support an oxidative quenching photoredox cycle featuring a sulfinate intermediate.",A,MAC_Bench/ACS/Cover/ACS Catalysis/2024_9.png,MAC_Bench/ACS/Cover/ACS Catalysis/2024_9.png,groundtruth,2024_9.txt,MAC_Bench/ACS/Cover/ACS Catalysis/2021_14.png,MAC_Bench/ACS/Cover/ACS Catalysis/2021_14.png,vith,2021_14.txt,MAC_Bench/ACS/Cover/ACS Catalysis/2022_9.png,MAC_Bench/ACS/Cover/ACS Catalysis/2022_9.png,clip,2022_9.txt,MAC_Bench/ACS/Cover/ACS Catalysis/2022_11.png,MAC_Bench/ACS/Cover/ACS Catalysis/2022_11.png,vitg,2022_11.txt,train552ACS Energy Letters,2024_3,Which of the following options best describe the cover story?,Lithium tetrafluoroborate as a supplemental salt is systematically investigated in low-ethylene carbonate-content electrolytes. Electrolytes with a trace amount of lithium tetrafluoroborate (0.05 M),D,MAC_Bench/ACS/Cover/ACS Energy Letters/2019_9.png,MAC_Bench/ACS/Cover/ACS Energy Letters/2019_9.png,clip,2019_9.txt,MAC_Bench/ACS/Cover/ACS Energy Letters/2022_2.png,MAC_Bench/ACS/Cover/ACS Energy Letters/2022_2.png,ave_2,2022_2.txt,MAC_Bench/ACS/Cover/ACS Energy Letters/2022_8.png,MAC_Bench/ACS/Cover/ACS Energy Letters/2022_8.png,ave_3,2022_8.txt,MAC_Bench/ACS/Cover/ACS Energy Letters/2024_3.png,MAC_Bench/ACS/Cover/ACS Energy Letters/2024_3.png,groundtruth,2024_3.txt,train553Nature Reviews Cardiology,21_2,Which of the following options best describe the cover story?,"Atheroimmunology, inspired by the Review on p743554Cover design: Vicky Summersby",B,MAC_Bench/Nature/Cover/Nature Reviews Cardiology/20_2.png,MAC_Bench/Nature/Cover/Nature Reviews Cardiology/20_2.png,clip,20_2.txt,MAC_Bench/Nature/Cover/Nature Reviews Cardiology/21_2.png,MAC_Bench/Nature/Cover/Nature Reviews Cardiology/21_2.png,groundtruth,21_2.txt,MAC_Bench/Nature/Cover/Nature Reviews Cardiology/20_3.png,MAC_Bench/Nature/Cover/Nature Reviews Cardiology/20_3.png,vith,20_3.txt,MAC_Bench/Nature/Cover/Nature Reviews Cardiology/21_4.png,MAC_Bench/Nature/Cover/Nature Reviews Cardiology/21_4.png,vitg,21_4.txt,val555ACS Applied Energy Materials,2025_2,Which of the following options best describe the cover story?,"The cover art illustrates a porous carbon electrode integrated with a conductive, interconnected substrate. The heat dissipation within the porous structure represents efficient thermal management and electron transport, essential for high-performance energy-storage systems. The structured carbon layer facilitates ion diffusion and charge storage, emphasizing advancements in electrode design for battery technologies.",B,MAC_Bench/ACS/Cover/ACS Applied Energy Materials/2024_23.png,MAC_Bench/ACS/Cover/ACS Applied Energy Materials/2024_23.png,clip,2024_23.txt,MAC_Bench/ACS/Cover/ACS Applied Energy Materials/2025_2.png,MAC_Bench/ACS/Cover/ACS Applied Energy Materials/2025_2.png,groundtruth,2025_2.txt,MAC_Bench/ACS/Cover/ACS Applied Energy Materials/2023_18.png,MAC_Bench/ACS/Cover/ACS Applied Energy Materials/2023_18.png,vitg,2023_18.txt,MAC_Bench/ACS/Cover/ACS Applied Energy Materials/2023_2.png,MAC_Bench/ACS/Cover/ACS Applied Energy Materials/2023_2.png,ave_2,2023_2.txt,train556Caner Cell,42_8,Which of the following options best describe the cover story?,"On the cover: Dyikanov et al. develop a machine learning platform that classifies a patient’s immune system into557five immunotypes using a blood test. On the cover, the railway map represents these558immunotypes as train stations with distinct characteristics. G1-naive and G2-primed,559characteristic of immune systems with the greatest potential to respond to immunogenic560stimuli, are represented by a fertile, green landscape. G3-progressive is a transitional561immunotype represented by a central hub. The G4-chronic station is a heavily developed562urban landscape, symbolizing an immune system shaped by persistent activation and563chronic antigen exposure. G5-suppressive is a desert that represents a depleted immune564system. The trains ferry passengers among different stations along the railway lines,565symbolizing the dynamic nature of one’s immunotype depending on their health or disease566status. (Image credit: Alfiia Mustafina).",D,MAC_Bench/Cell/Cover/Caner Cell/42_9.png,MAC_Bench/Cell/Cover/Caner Cell/42_9.png,clip,42_9.txt,MAC_Bench/Cell/Cover/Caner Cell/41_4.png,MAC_Bench/Cell/Cover/Caner Cell/41_4.png,vitg,41_4.txt,MAC_Bench/Cell/Cover/Caner Cell/38_5.png,MAC_Bench/Cell/Cover/Caner Cell/38_5.png,ave_2,38_5.txt,MAC_Bench/Cell/Cover/Caner Cell/42_8.png,MAC_Bench/Cell/Cover/Caner Cell/42_8.png,groundtruth,42_8.txt,val567NATURE MEDICINE,30_3,Which of the following options best describe the cover story?,"Unidirectional risk effects of clonal hematopoiesis on atherosclerosis568In this issue, Fuster and colleagues find that clonal hematopoiesis confers an increased risk of atherosclerosis. The cover highlights the finding that atherosclerosis, in turn, does not affect the risk of clonal hematopoiesis, indicative of a unidirectional effect.569See Fuster et al.570Image: Rosa Moro, Centro Nacional de Investigaciones Cardiovasculares. Cover design: Marina Corral Spence",B,MAC_Bench/Nature/Cover/NATURE MEDICINE/30_7.png,MAC_Bench/Nature/Cover/NATURE MEDICINE/30_7.png,vith,30_7.txt,MAC_Bench/Nature/Cover/NATURE MEDICINE/30_3.png,MAC_Bench/Nature/Cover/NATURE MEDICINE/30_3.png,groundtruth,30_3.txt,MAC_Bench/Nature/Cover/NATURE MEDICINE/27_8.png,MAC_Bench/Nature/Cover/NATURE MEDICINE/27_8.png,vitg,27_8.txt,MAC_Bench/Nature/Cover/NATURE MEDICINE/30_2.png,MAC_Bench/Nature/Cover/NATURE MEDICINE/30_2.png,clip,30_2.txt,train571Accounts of Chemical Research,2024_16,Which of the following options best describe the cover story?,"Heterogeneous nanocrystal formation with metals controlled by electrostatic force, ion enrichment, and interfacial energy through metal",C,MAC_Bench/ACS/Cover/Accounts of Chemical Research/2023_17.png,MAC_Bench/ACS/Cover/Accounts of Chemical Research/2023_17.png,vitg,2023_17.txt,MAC_Bench/ACS/Cover/Accounts of Chemical Research/2024_12.png,MAC_Bench/ACS/Cover/Accounts of Chemical Research/2024_12.png,vith,2024_12.txt,MAC_Bench/ACS/Cover/Accounts of Chemical Research/2024_16.png,MAC_Bench/ACS/Cover/Accounts of Chemical Research/2024_16.png,groundtruth,2024_16.txt,MAC_Bench/ACS/Cover/Accounts of Chemical Research/2024_6.png,MAC_Bench/ACS/Cover/Accounts of Chemical Research/2024_6.png,clip,2024_6.txt,train572Nature Climate Change,14_9,Which of the following options best describe the cover story?,"Losing meteorites573Most of the meteorites in today's collections have been found in Antarctica, making it a key region for planetary science. Writing in this issue, Tollenaar, Zekollari and colleagues show that surface melt due to climate change can lead to substantial portions of current meteorites sinking into the ice, leaving bare blue ice areas void of any of these precious space rocks, making them unavailable for science.574See Tollenaar et al. and News & Views by Righter575Image: Veronica Tollenaar, Université libre de Bruxelles. Cover design: Valentina Monaco",C,MAC_Bench/Nature/Cover/Nature Climate Change/13_4.png,MAC_Bench/Nature/Cover/Nature Climate Change/13_4.png,clip,13_4.txt,MAC_Bench/Nature/Cover/Nature Climate Change/13_9.png,MAC_Bench/Nature/Cover/Nature Climate Change/13_9.png,ave_2,13_9.txt,MAC_Bench/Nature/Cover/Nature Climate Change/14_9.png,MAC_Bench/Nature/Cover/Nature Climate Change/14_9.png,groundtruth,14_9.txt,MAC_Bench/Nature/Cover/Nature Climate Change/11_9.png,MAC_Bench/Nature/Cover/Nature Climate Change/11_9.png,vith,11_9.txt,train576Molecular Therapy,32_4,Which of the following options best describe the cover story?,"On the cover: The cover is an abstract photograph capturing many and various marvels at the Gardens577by the Bay in Singapore. It symbolizes the variety of targets to be discovered in578the field of cell and gene therapy and the hazy complexity of the methodologies aimed579at their identification. Image credit: Pierluigi Di Pietro.",B,MAC_Bench/Cell/Cover/Molecular Therapy/31_16.png,MAC_Bench/Cell/Cover/Molecular Therapy/31_16.png,vitg,31_16.txt,MAC_Bench/Cell/Cover/Molecular Therapy/32_4.png,MAC_Bench/Cell/Cover/Molecular Therapy/32_4.png,groundtruth,32_4.txt,MAC_Bench/Cell/Cover/Molecular Therapy/27_4.png,MAC_Bench/Cell/Cover/Molecular Therapy/27_4.png,vith,27_4.txt,MAC_Bench/Cell/Cover/Molecular Therapy/30_17.png,MAC_Bench/Cell/Cover/Molecular Therapy/30_17.png,clip,30_17.txt,val580ACS Applied Polymer Materials,2024_18,Which of the following options best describe the cover story?,"niversal controlled-release system based on cubosome-carrying bacterial cellulose capsules with a pH-smart trigger mechanism for the oral administration of therapeutic bioactives is rationally designed. Site-specific, dual cargo-controlled release is achieved through a solubility-dependent phenomenon. Such an engineered pH-responsive microcapsule has potential for colon-targeted multidrug delivery.",B,MAC_Bench/ACS/Cover/ACS Applied Polymer Materials/2023_2.png,MAC_Bench/ACS/Cover/ACS Applied Polymer Materials/2023_2.png,vith,2023_2.txt,MAC_Bench/ACS/Cover/ACS Applied Polymer Materials/2024_18.png,MAC_Bench/ACS/Cover/ACS Applied Polymer Materials/2024_18.png,groundtruth,2024_18.txt,MAC_Bench/ACS/Cover/ACS Applied Polymer Materials/2022_3.png,MAC_Bench/ACS/Cover/ACS Applied Polymer Materials/2022_3.png,vitg,2022_3.txt,MAC_Bench/ACS/Cover/ACS Applied Polymer Materials/2022_6.png,MAC_Bench/ACS/Cover/ACS Applied Polymer Materials/2022_6.png,clip,2022_6.txt,train581Trends in Pharmacological Sciences,45_4,Which of the following options best describe the cover story?,"Autoantibody binding is central to autoimmune diseases and broadly582linked to cancer, infections, and behavioural disorders. The lack of understanding583of disease-specific epitopes — crucial for pathology and diagnosis — has led to584misclassification of autoimmune neurological diseases. In this issue, Ivan Talucci585and586Hans Michael Maric propose the utilization of newly available technology to decode587epitope landscapes in neurological diseases to unlock new avenues for patient588diagnosis and treatment. They highlight the relevance of B and T cell epitopes for589identifying biomarkers in high-risk patients and discuss how synthetic and cellularsurface590display technologies can improve diagnosis and enable treatments. The591cover image depicts a combination of epitope landscapes decoded from microarray592chip-based experiments. Cover designed by Ivan Talucci and Hans Michael Maric593using Adobe illustrator and Photoshop.",A,MAC_Bench/Cell/Cover/Trends in Pharmacological Sciences/45_4.png,MAC_Bench/Cell/Cover/Trends in Pharmacological Sciences/45_4.png,groundtruth,45_4.txt,MAC_Bench/Cell/Cover/Trends in Pharmacological Sciences/44_12.png,MAC_Bench/Cell/Cover/Trends in Pharmacological Sciences/44_12.png,ave_2,44_12.txt,MAC_Bench/Cell/Cover/Trends in Pharmacological Sciences/45_11.png,MAC_Bench/Cell/Cover/Trends in Pharmacological Sciences/45_11.png,vitg,45_11.txt,MAC_Bench/Cell/Cover/Trends in Pharmacological Sciences/44_10.png,MAC_Bench/Cell/Cover/Trends in Pharmacological Sciences/44_10.png,clip,44_10.txt,train594ACS Sustainable Resource Management,2025_1,Which of the following options best describe the cover story?,Thermoprocessing glycerol/water-plasticized biopolymers with bio-waste using industrial methods to replace industrial processing of plastics with renewable materials.,A,MAC_Bench/ACS/Cover/ACS Sustainable Resource Management/2025_1.png,MAC_Bench/ACS/Cover/ACS Sustainable Resource Management/2025_1.png,groundtruth,2025_1.txt,MAC_Bench/ACS/Cover/ACS Sustainable Resource Management/2025_2.png,MAC_Bench/ACS/Cover/ACS Sustainable Resource Management/2025_2.png,clip,2025_2.txt,MAC_Bench/ACS/Cover/ACS Sustainable Resource Management/2024_9.png,MAC_Bench/ACS/Cover/ACS Sustainable Resource Management/2024_9.png,ave_3,2024_9.txt,MAC_Bench/ACS/Cover/ACS Sustainable Resource Management/2024_10.png,MAC_Bench/ACS/Cover/ACS Sustainable Resource Management/2024_10.png,ave_2,2024_10.txt,test595Structure,33_1,Which of the following options best describe the cover story?,"On the cover: Alternative complex III from Chloroflexus aurantiacus (CaACIII) is a multi-subunit quinol acceptor oxidoreductase that couples quinol oxidation596with transmembrane proton translocation in respiratory and photosynthetic electron597transport chains. This image shows CaACIII structures determined by X-ray crystallography598and cryoelectron microscopy. The CaACIII crystal structure presented in this issue599by Wu et al. highlights the conformational stability of its core functional modules and reveals600local flexibility in regions with low sequence conservation.",C,MAC_Bench/Cell/Cover/Structure/33_2.png,MAC_Bench/Cell/Cover/Structure/33_2.png,clip,33_2.txt,MAC_Bench/Cell/Cover/Structure/32_10.png,MAC_Bench/Cell/Cover/Structure/32_10.png,ave_2,32_10.txt,MAC_Bench/Cell/Cover/Structure/33_1.png,MAC_Bench/Cell/Cover/Structure/33_1.png,groundtruth,33_1.txt,MAC_Bench/Cell/Cover/Structure/32_1.png,MAC_Bench/Cell/Cover/Structure/32_1.png,ave_3,32_1.txt,train601Trends in Microbiology,32_10,Which of the following options best describe the cover story?,"Traits-based approaches have gained increasing attention for602studying plant–microbe interactions especially from an ecological standpoint.603However, many of the functional traits currently used pose a significant problem:604high intraspecific variations. In order to address this, in the current issue, Dr.605Zhang606and colleagues consider plant genome size as a trait that can be harnessed to study607microbiome-mediated interactions and adaptations to environmental changes.608Image courtesy: GettyImages (Andriy Onufriyenko)",A,MAC_Bench/Cell/Cover/Trends in Microbiology/32_10.png,MAC_Bench/Cell/Cover/Trends in Microbiology/32_10.png,groundtruth,32_10.txt,MAC_Bench/Cell/Cover/Trends in Microbiology/32_6.png,MAC_Bench/Cell/Cover/Trends in Microbiology/32_6.png,vitg,32_6.txt,MAC_Bench/Cell/Cover/Trends in Microbiology/30_4.png,MAC_Bench/Cell/Cover/Trends in Microbiology/30_4.png,clip,30_4.txt,MAC_Bench/Cell/Cover/Trends in Microbiology/32_5.png,MAC_Bench/Cell/Cover/Trends in Microbiology/32_5.png,vith,32_5.txt,train609Molecular Plant,17_12,Which of the following options best describe the cover story?,"On the cover: The cover image illustrates a leaf of the fern Ceratopteris richardii infected by the pathogenic fungus Sclerotinia scleroriorum. An angiosperm pathogen can infect a non-angiosperm plant, suggesting at least partial610conservation of molecular regulation of plant-microbe interactions. Overlay of real611colour image and 488nm-excited fluorescent image after dye with GFP-conjugated Wheat612Germ Agglutin, known to bind chitin. Image by Baptiste CASTEL with the assistance613of NightCafé (https://creator.nightcafe.studio).",C,MAC_Bench/Cell/Cover/Molecular Plant/16_11.png,MAC_Bench/Cell/Cover/Molecular Plant/16_11.png,ave_2,16_11.txt,MAC_Bench/Cell/Cover/Molecular Plant/17_13.png,MAC_Bench/Cell/Cover/Molecular Plant/17_13.png,clip,17_13.txt,MAC_Bench/Cell/Cover/Molecular Plant/17_12.png,MAC_Bench/Cell/Cover/Molecular Plant/17_12.png,groundtruth,17_12.txt,MAC_Bench/Cell/Cover/Molecular Plant/17_5.png,MAC_Bench/Cell/Cover/Molecular Plant/17_5.png,ave_3,17_5.txt,train614JACS Au,2024_10,Which of the following options best describe the cover story?,"The membrane-bound phospholipase A1 from Pseudomonas aeruginosa is a potential drug target. PlaF remodels membrane glycerophospholipids, influencing virulence-associated signaling. Medium-chain free fatty acids, products of PlaF action, inhibit its activity. Molecular simulations and free energy computations uncover how fatty acids control PlaF. For this image, an author-made hand drawing was refined with GPT-4.",C,MAC_Bench/ACS/Cover/JACS Au/2022_12.png,MAC_Bench/ACS/Cover/JACS Au/2022_12.png,vitg,2022_12.txt,MAC_Bench/ACS/Cover/JACS Au/2021_8.png,MAC_Bench/ACS/Cover/JACS Au/2021_8.png,clip,2021_8.txt,MAC_Bench/ACS/Cover/JACS Au/2024_10.png,MAC_Bench/ACS/Cover/JACS Au/2024_10.png,groundtruth,2024_10.txt,MAC_Bench/ACS/Cover/JACS Au/2023_5.png,MAC_Bench/ACS/Cover/JACS Au/2023_5.png,vith,2023_5.txt,val615BDJ,238_2,Which of the following options best describe the cover story?,"In this issue616This issue features articles on antibiotic prophylaxis, indirect pulp capping, and artificial intelligence.617 618Cover image: Teamwork. No one-man band here. What’s a practice or procedure without the team behind it?619My venture into illustrations originated as a fun and creative way to relax and learn anatomy and instruments during my commutes to and from my dental foundation year. I was fond of art growing up and had strongly considered going into film-set design and art foundation opposed to the sciences. I wanted to get back into drawing after finishing dental school and I found digital dental illustrations through this.620©Pippasha Khan @DrPippa.K",D,MAC_Bench/Nature/Cover/BDJ/238_1.png,MAC_Bench/Nature/Cover/BDJ/238_1.png,ave_3,238_1.txt,MAC_Bench/Nature/Cover/BDJ/228_4.png,MAC_Bench/Nature/Cover/BDJ/228_4.png,clip,228_4.txt,MAC_Bench/Nature/Cover/BDJ/228_10.png,MAC_Bench/Nature/Cover/BDJ/228_10.png,vitg,228_10.txt,MAC_Bench/Nature/Cover/BDJ/238_2.png,MAC_Bench/Nature/Cover/BDJ/238_2.png,groundtruth,238_2.txt,train621ACS Synthetic Biology,2025_2,Which of the following options best describe the cover story?,"The key economic indicators, namely, titer, rate, and yield (TRY) that, respectively, reflect the downstream processing, reactor size, and raw material costs, serve as useful ways to benchmark intensified fermentation processes. BioTRY provides a user-friendly interface for querying, browsing, and visualizing TRY records in microbial processes.",D,MAC_Bench/ACS/Cover/ACS Synthetic Biology/2024_10.png,MAC_Bench/ACS/Cover/ACS Synthetic Biology/2024_10.png,ave_2,2024_10.txt,MAC_Bench/ACS/Cover/ACS Synthetic Biology/2025_1.png,MAC_Bench/ACS/Cover/ACS Synthetic Biology/2025_1.png,vitg,2025_1.txt,MAC_Bench/ACS/Cover/ACS Synthetic Biology/2022_12.png,MAC_Bench/ACS/Cover/ACS Synthetic Biology/2022_12.png,clip,2022_12.txt,MAC_Bench/ACS/Cover/ACS Synthetic Biology/2025_2.png,MAC_Bench/ACS/Cover/ACS Synthetic Biology/2025_2.png,groundtruth,2025_2.txt,train622Immunity,58_2,Which of the following options best describe the cover story?,"On the cover: Inpp5d, a risk gene for Alzheimer’s disease, encodes the lipid phosphatase SHIP1. Matera, Compagnion, et al. demonstrate that Inpp5d is expressed in microglia during early postnatal brain development, where it limits623synaptic pruning in a complement-dependent manner. Perturbation of Inpp5d during brain development has long-lasting effects on cognitive function. The cover624image depicts microglial cells (magenta) interacting with neurons (cyan) in the mouse625CA1 hippocampal region during early development, specifically at postnatal day 15.626The plasticity and dynamism of microglia, which constantly scan the brain environment,627are highlighted by oil painting effect. Image acquisition and editing by Alessandro628Matera.",B,MAC_Bench/Cell/Cover/Immunity/55_11.png,MAC_Bench/Cell/Cover/Immunity/55_11.png,ave_2,55_11.txt,MAC_Bench/Cell/Cover/Immunity/58_2.png,MAC_Bench/Cell/Cover/Immunity/58_2.png,groundtruth,58_2.txt,MAC_Bench/Cell/Cover/Immunity/55_6.png,MAC_Bench/Cell/Cover/Immunity/55_6.png,ave_3,55_6.txt,MAC_Bench/Cell/Cover/Immunity/58_1.png,MAC_Bench/Cell/Cover/Immunity/58_1.png,clip,58_1.txt,train629Journal of Medicinal Chemistry,2024_17,Which of the following options best describe the cover story?,Bipyridine–silver(I) compounds with phosphane co-ligands induce paraptotic cell death and emerge as interesting drug candidates for the treatment of resistant ovarian cancer (created with BioRender.com). View the article.,B,MAC_Bench/ACS/Cover/Journal of Medicinal Chemistry/2023_15.png,MAC_Bench/ACS/Cover/Journal of Medicinal Chemistry/2023_15.png,clip,2023_15.txt,MAC_Bench/ACS/Cover/Journal of Medicinal Chemistry/2024_17.png,MAC_Bench/ACS/Cover/Journal of Medicinal Chemistry/2024_17.png,groundtruth,2024_17.txt,MAC_Bench/ACS/Cover/Journal of Medicinal Chemistry/2023_4.png,MAC_Bench/ACS/Cover/Journal of Medicinal Chemistry/2023_4.png,vith,2023_4.txt,MAC_Bench/ACS/Cover/Journal of Medicinal Chemistry/2009_19.png,MAC_Bench/ACS/Cover/Journal of Medicinal Chemistry/2009_19.png,vitg,2009_19.txt,val630Science Robotics,9_89,Which of the following options best describe the cover story?,"ONLINE COVER Special Issue on Legged Robots. Developing legged robots capable of complex motor skills is a major challenge for roboticists. Haarnoja et al. used deep reinforcement learning to train miniature humanoid robots, Robotis OP3, to play a game of one-versus-one soccer. The robots were capable of exhibiting not only agile movements, such as walking, kicking the ball, and rapid recovery from falls, but also emergent behaviors to adapt to the game scenario, such as subtle defensive moves and dynamic footwork in response to the opponent. This month’s cover is an image of the miniature humanoid robot kicking a ball. Credit: Google DeepMind",C,MAC_Bench/Science/Cover/Science Robotics/6_54.png,MAC_Bench/Science/Cover/Science Robotics/6_54.png,vitg,6_54.txt,MAC_Bench/Science/Cover/Science Robotics/9_96.png,MAC_Bench/Science/Cover/Science Robotics/9_96.png,clip,9_96.txt,MAC_Bench/Science/Cover/Science Robotics/9_89.png,MAC_Bench/Science/Cover/Science Robotics/9_89.png,groundtruth,9_89.txt,MAC_Bench/Science/Cover/Science Robotics/4_31.png,MAC_Bench/Science/Cover/Science Robotics/4_31.png,vith,4_31.txt,train631Nature Reviews Rheumatology,20_8,Which of the following options best describe the cover story?,"Inspired by the Review on p258632Cover design: Steven Hall",B,MAC_Bench/Nature/Cover/Nature Reviews Rheumatology/20_2.png,MAC_Bench/Nature/Cover/Nature Reviews Rheumatology/20_2.png,vith,20_2.txt,MAC_Bench/Nature/Cover/Nature Reviews Rheumatology/20_8.png,MAC_Bench/Nature/Cover/Nature Reviews Rheumatology/20_8.png,groundtruth,20_8.txt,MAC_Bench/Nature/Cover/Nature Reviews Rheumatology/20_7.png,MAC_Bench/Nature/Cover/Nature Reviews Rheumatology/20_7.png,clip,20_7.txt,MAC_Bench/Nature/Cover/Nature Reviews Rheumatology/19_10.png,MAC_Bench/Nature/Cover/Nature Reviews Rheumatology/19_10.png,ave_1,19_10.txt,train633Environmental Science & Technology,2025_2,Which of the following options best describe the cover story?,NO3RR,B,MAC_Bench/ACS/Cover/Environmental Science & Technology/2022_6.png,MAC_Bench/ACS/Cover/Environmental Science & Technology/2022_6.png,clip,2022_6.txt,MAC_Bench/ACS/Cover/Environmental Science & Technology/2025_2.png,MAC_Bench/ACS/Cover/Environmental Science & Technology/2025_2.png,groundtruth,2025_2.txt,MAC_Bench/ACS/Cover/Environmental Science & Technology/2024_7.png,MAC_Bench/ACS/Cover/Environmental Science & Technology/2024_7.png,vitg,2024_7.txt,MAC_Bench/ACS/Cover/Environmental Science & Technology/2024_16.png,MAC_Bench/ACS/Cover/Environmental Science & Technology/2024_16.png,vith,2024_16.txt,train634Nature Photonics,18_6,Which of the following options best describe the cover story?,"Terahertz-driven electron guns635Artist’s impression of a waveguide-based terahertz-driven photogun that serves as a compact source of high-energy electrons. The design exploits a movable cathode tip and multiple cells to provide an acceleration gradient as high as ~3 GV/m. Using microjoule-level single-cycle terahertz pulses, electron beams with up to ~14 keV electron energy, 1% energy spread and ~0.015 mm mrad transverse emittance are possible.636See Ying et al.637Image: Jianwei Ying and Dongfang Zhang, Shanghai Jiao Tong University. Cover design: Bethany Vukomanovic",C,MAC_Bench/Nature/Cover/Nature Photonics/16_10.png,MAC_Bench/Nature/Cover/Nature Photonics/16_10.png,ave_2,16_10.txt,MAC_Bench/Nature/Cover/Nature Photonics/15_7.png,MAC_Bench/Nature/Cover/Nature Photonics/15_7.png,ave_3,15_7.txt,MAC_Bench/Nature/Cover/Nature Photonics/18_6.png,MAC_Bench/Nature/Cover/Nature Photonics/18_6.png,groundtruth,18_6.txt,MAC_Bench/Nature/Cover/Nature Photonics/16_7.png,MAC_Bench/Nature/Cover/Nature Photonics/16_7.png,clip,16_7.txt,train638Nature Reviews Nephrology,20_4,Which of the following options best describe the cover story?,"The ageing world, inspired by the Focus starting on p557.639Cover design: Lara Crow",D,MAC_Bench/Nature/Cover/Nature Reviews Nephrology/20_12.png,MAC_Bench/Nature/Cover/Nature Reviews Nephrology/20_12.png,clip,20_12.txt,MAC_Bench/Nature/Cover/Nature Reviews Nephrology/19_5.png,MAC_Bench/Nature/Cover/Nature Reviews Nephrology/19_5.png,ave_3,19_5.txt,MAC_Bench/Nature/Cover/Nature Reviews Nephrology/19_7.png,MAC_Bench/Nature/Cover/Nature Reviews Nephrology/19_7.png,ave_2,19_7.txt,MAC_Bench/Nature/Cover/Nature Reviews Nephrology/20_4.png,MAC_Bench/Nature/Cover/Nature Reviews Nephrology/20_4.png,groundtruth,20_4.txt,train640Molecular Therapy,32_6,Which of the following options best describe the cover story?,"On the cover:Smith et al. engineer novel immunoglobulin cleaving enzymes with the ability to target IgM, a641key trigger in the anti-AAV immune cascade. The image displays structural models of642the newly engineered enzyme (IceMG, blue and orange) docking onto and cleaving pentameric643IgM or monomeric IgG (gray) that are shown neutralizing an adeno-associated viral644(AAV) capsid (rainbow). Image credit: Timothy Smith, PhD.",A,MAC_Bench/Cell/Cover/Molecular Therapy/32_6.png,MAC_Bench/Cell/Cover/Molecular Therapy/32_6.png,groundtruth,32_6.txt,MAC_Bench/Cell/Cover/Molecular Therapy/28_13.png,MAC_Bench/Cell/Cover/Molecular Therapy/28_13.png,vitg,28_13.txt,MAC_Bench/Cell/Cover/Molecular Therapy/32_3.png,MAC_Bench/Cell/Cover/Molecular Therapy/32_3.png,clip,32_3.txt,MAC_Bench/Cell/Cover/Molecular Therapy/31_17.png,MAC_Bench/Cell/Cover/Molecular Therapy/31_17.png,vith,31_17.txt,train645ACS Agricultural Science & Technology,2024_4,Which of the following options best describe the cover story?,"Non-covalent interactions between pesticides and carriers in pesticide controlled-release systems significantly impact the system's stability, stimulus responsiveness, loading capacity, and physicochemical properties of pesticides, such as hydrogen-bonding interactions, electrostatic interactions, hydrophobic interactions, and supramolecular host–guest interactions. Modifying multiple assembly sites on carriers or combining various carriers to construct a new type of pesticide controlled-release system with multiple non-covalent bond interactions can play a more significant role in the development of green agriculture.",B,MAC_Bench/ACS/Cover/ACS Agricultural Science & Technology/2023_1.png,MAC_Bench/ACS/Cover/ACS Agricultural Science & Technology/2023_1.png,clip,2023_1.txt,MAC_Bench/ACS/Cover/ACS Agricultural Science & Technology/2024_4.png,MAC_Bench/ACS/Cover/ACS Agricultural Science & Technology/2024_4.png,groundtruth,2024_4.txt,MAC_Bench/ACS/Cover/ACS Agricultural Science & Technology/2024_5.png,MAC_Bench/ACS/Cover/ACS Agricultural Science & Technology/2024_5.png,ave_2,2024_5.txt,MAC_Bench/ACS/Cover/ACS Agricultural Science & Technology/2023_2.png,MAC_Bench/ACS/Cover/ACS Agricultural Science & Technology/2023_2.png,ave_3,2023_2.txt,val646Bioconjugate Chemistry,2024_10,Which of the following options best describe the cover story?,"Engineering of the primary structural protein of gas vesicles, GvpA, with the tetracysteine tag enables its reaction with the fluorogenic molecule FlAsH and subsequent visualization of the assembled gas vesicle structures inside cells with fluorescence microscopy.",D,MAC_Bench/ACS/Cover/Bioconjugate Chemistry/2019_10.png,MAC_Bench/ACS/Cover/Bioconjugate Chemistry/2019_10.png,vith,2019_10.txt,MAC_Bench/ACS/Cover/Bioconjugate Chemistry/2017_9.png,MAC_Bench/ACS/Cover/Bioconjugate Chemistry/2017_9.png,vitg,2017_9.txt,MAC_Bench/ACS/Cover/Bioconjugate Chemistry/2024_8.png,MAC_Bench/ACS/Cover/Bioconjugate Chemistry/2024_8.png,clip,2024_8.txt,MAC_Bench/ACS/Cover/Bioconjugate Chemistry/2024_10.png,MAC_Bench/ACS/Cover/Bioconjugate Chemistry/2024_10.png,groundtruth,2024_10.txt,test647NATURE MATERIALS,23_12,Which of the following options best describe the cover story?,"Magnetoelectric metamaterials for neurostimulation648Self-rectifying magnetoelectric metamaterials with nonlinear responses generate electrical pulse sequences that enable precisely timed remote neural stimulation and restoration of sensory motor responses in vivo.649See Chen et al.650Image: Maayan Harel. Cover design: Alex Whitworth",D,MAC_Bench/Nature/Cover/NATURE MATERIALS/21_7.png,MAC_Bench/Nature/Cover/NATURE MATERIALS/21_7.png,vitg,21_7.txt,MAC_Bench/Nature/Cover/NATURE MATERIALS/20_6.png,MAC_Bench/Nature/Cover/NATURE MATERIALS/20_6.png,ave_2,20_6.txt,MAC_Bench/Nature/Cover/NATURE MATERIALS/21_11.png,MAC_Bench/Nature/Cover/NATURE MATERIALS/21_11.png,clip,21_11.txt,MAC_Bench/Nature/Cover/NATURE MATERIALS/23_12.png,MAC_Bench/Nature/Cover/NATURE MATERIALS/23_12.png,groundtruth,23_12.txt,train651Chemistry of Materials,2025_4,Which of the following options best describe the cover story?,"The cover art visually captures the fusion of nanomaterials with mitochondria targeting, imaging, and image-guided treatment. The mitochondria are targeted by floating molecules, such as rhodamine and",A,MAC_Bench/ACS/Cover/Chemistry of Materials/2025_4.png,MAC_Bench/ACS/Cover/Chemistry of Materials/2025_4.png,groundtruth,2025_4.txt,MAC_Bench/ACS/Cover/Chemistry of Materials/2021_21.png,MAC_Bench/ACS/Cover/Chemistry of Materials/2021_21.png,vith,2021_21.txt,MAC_Bench/ACS/Cover/Chemistry of Materials/2021_22.png,MAC_Bench/ACS/Cover/Chemistry of Materials/2021_22.png,vitg,2021_22.txt,MAC_Bench/ACS/Cover/Chemistry of Materials/2021_1.png,MAC_Bench/ACS/Cover/Chemistry of Materials/2021_1.png,clip,2021_1.txt,train652Science Signaling,2007_409,Which of the following options best describe the cover story?,"COVER This week features a Review concerning the possible role of asparagine deamidation as a genetically programmed molecular timer of biological processes. [Image: Christopher Bickel, AAAS]",C,MAC_Bench/Science/Cover/Science Signaling/2007_394.png,MAC_Bench/Science/Cover/Science Signaling/2007_394.png,vitg,2007_394.txt,MAC_Bench/Science/Cover/Science Signaling/2007_390.png,MAC_Bench/Science/Cover/Science Signaling/2007_390.png,vith,2007_390.txt,MAC_Bench/Science/Cover/Science Signaling/2007_409.png,MAC_Bench/Science/Cover/Science Signaling/2007_409.png,groundtruth,2007_409.txt,MAC_Bench/Science/Cover/Science Signaling/2007_411.png,MAC_Bench/Science/Cover/Science Signaling/2007_411.png,clip,2007_411.txt,train653Nature Chemical Engineering,1_4,Which of the following options best describe the cover story?,"Stirring up plastics recycling654Emerging catalytic techniques can valorize plastic waste into valuable products. In addition to the ongoing search for more effective catalysts, disclosing the potential of these technologies requires dedicated reaction engineering efforts. Now, Javier Pérez-Ramírez and co-workers show how critical optimal mixing is in the three-phase hydrogenolysis of polyolefins. Following catalytic evaluation and computational fluid dynamics simulations, they derive an accessible quantitative criterion for determining stirring configurations to maximize catalyst effectiveness. This marks an important step towards standardized benchmarking of catalytic technologies. The cover depicts the top view of catalyst particle trajectories in a plastic melt when stirred with the optimal geometry.655See Jaydev et al. and Soltani & Rorrer656Image: Constance Ko and Javier Pérez-Ramírez, ETH Zurich. Cover design: Thomas Phillips.",A,MAC_Bench/Nature/Cover/Nature Chemical Engineering/1_4.png,MAC_Bench/Nature/Cover/Nature Chemical Engineering/1_4.png,groundtruth,1_4.txt,MAC_Bench/Nature/Cover/Nature Chemical Engineering/1_3.png,MAC_Bench/Nature/Cover/Nature Chemical Engineering/1_3.png,clip,1_3.txt,MAC_Bench/Nature/Cover/Nature Chemical Engineering/1_11.png,MAC_Bench/Nature/Cover/Nature Chemical Engineering/1_11.png,vith,1_11.txt,MAC_Bench/Nature/Cover/Nature Chemical Engineering/1_1.png,MAC_Bench/Nature/Cover/Nature Chemical Engineering/1_1.png,ave_3,1_1.txt,test657Cell Genomics,4_11,Which of the following options best describe the cover story?,"On the cover: In this issue of Cell Genomics, Xu et al. present their findings that Epstein-Barr virus (EBV)-host genetic interaction predisposes658susceptibility to nasopharyngeal carcinoma (NPC). This EBV-related cancer, though659rare in most parts of the world, is highly endemic in southern China. Illustrated660on the cover, the red virus and double-stranded DNA symbols capture the strong interaction661between the high-risk subtype of EBV and susceptible HLA alleles. This interaction662is the major determinant of NPC risk among southern Chinese populations. The cover663art was created by the artist Rui Xie.",C,MAC_Bench/Cell/Cover/Cell Genomics/3_5.png,MAC_Bench/Cell/Cover/Cell Genomics/3_5.png,clip,3_5.txt,MAC_Bench/Cell/Cover/Cell Genomics/3_11.png,MAC_Bench/Cell/Cover/Cell Genomics/3_11.png,ave_2,3_11.txt,MAC_Bench/Cell/Cover/Cell Genomics/4_11.png,MAC_Bench/Cell/Cover/Cell Genomics/4_11.png,groundtruth,4_11.txt,MAC_Bench/Cell/Cover/Cell Genomics/4_12.png,MAC_Bench/Cell/Cover/Cell Genomics/4_12.png,ave_3,4_12.txt,train664Nature Reviews Clinical Oncology,21_12,Which of the following options best describe the cover story?,"Using computational tools to predict response to immunotherapies, inspired by the Review on p28.665Cover design: Lara Crow",D,MAC_Bench/Nature/Cover/Nature Reviews Clinical Oncology/20_10.png,MAC_Bench/Nature/Cover/Nature Reviews Clinical Oncology/20_10.png,clip,20_10.txt,MAC_Bench/Nature/Cover/Nature Reviews Clinical Oncology/20_1.png,MAC_Bench/Nature/Cover/Nature Reviews Clinical Oncology/20_1.png,vith,20_1.txt,MAC_Bench/Nature/Cover/Nature Reviews Clinical Oncology/21_6.png,MAC_Bench/Nature/Cover/Nature Reviews Clinical Oncology/21_6.png,vitg,21_6.txt,MAC_Bench/Nature/Cover/Nature Reviews Clinical Oncology/21_12.png,MAC_Bench/Nature/Cover/Nature Reviews Clinical Oncology/21_12.png,groundtruth,21_12.txt,train666Science Signaling,2007_389,Which of the following options best describe the cover story?,"COVER This week features a Protocol on detecting protein interactions with capture beads and flow cytometry. [Image: Christopher Bickel, AAAS]",D,MAC_Bench/Science/Cover/Science Signaling/2007_397.png,MAC_Bench/Science/Cover/Science Signaling/2007_397.png,vith,2007_397.txt,MAC_Bench/Science/Cover/Science Signaling/2007_377.png,MAC_Bench/Science/Cover/Science Signaling/2007_377.png,clip,2007_377.txt,MAC_Bench/Science/Cover/Science Signaling/2007_392.png,MAC_Bench/Science/Cover/Science Signaling/2007_392.png,vitg,2007_392.txt,MAC_Bench/Science/Cover/Science Signaling/2007_389.png,MAC_Bench/Science/Cover/Science Signaling/2007_389.png,groundtruth,2007_389.txt,val667ACS Agricultural Science & Technology,2024_8,Which of the following options best describe the cover story?,"This cover art suggests whether Surat city's soil is dominated by microplastics? The diamond symbol represents Surat's identity as the ""Diamond City"", while the thread symbolizes its thriving textile industry in Gujarat, India. The representation of garbage and plastic waste dumping reflects the daily disposal of such waste from both industrial and household sources. The lower portion of the artwork illustrates the pollution of soil by single-use plastic products within the city. The presence of the sun signifies the breakdown of large plastics into smaller microplastics, driven by UV degradation and other environmental factors. This transformation is further depicted through a magnifying lens, showcasing various shapes, such as fragments, fibers, films, and spheres, highlighting the biological and physical degradation of plastics.",A,MAC_Bench/ACS/Cover/ACS Agricultural Science & Technology/2024_8.png,MAC_Bench/ACS/Cover/ACS Agricultural Science & Technology/2024_8.png,groundtruth,2024_8.txt,MAC_Bench/ACS/Cover/ACS Agricultural Science & Technology/2023_2.png,MAC_Bench/ACS/Cover/ACS Agricultural Science & Technology/2023_2.png,clip,2023_2.txt,MAC_Bench/ACS/Cover/ACS Agricultural Science & Technology/2024_5.png,MAC_Bench/ACS/Cover/ACS Agricultural Science & Technology/2024_5.png,ave_2,2024_5.txt,MAC_Bench/ACS/Cover/ACS Agricultural Science & Technology/2022_5.png,MAC_Bench/ACS/Cover/ACS Agricultural Science & Technology/2022_5.png,vitg,2022_5.txt,train668Nature Reviews Physics,6_5,Which of the following options best describe the cover story?,"The cover of this issue is based on ab initio predictions of superconducting critical temperatures. See Pellegrini & Sanna669Image: Adapted from Pellegrini, C. & Sanna, A. Nat. Rev. Phys. (2024) Cover design: Susanne Harris.",D,MAC_Bench/Nature/Cover/Nature Reviews Physics/7_1.png,MAC_Bench/Nature/Cover/Nature Reviews Physics/7_1.png,ave_3,7_1.txt,MAC_Bench/Nature/Cover/Nature Reviews Physics/6_6.png,MAC_Bench/Nature/Cover/Nature Reviews Physics/6_6.png,clip,6_6.txt,MAC_Bench/Nature/Cover/Nature Reviews Physics/6_3.png,MAC_Bench/Nature/Cover/Nature Reviews Physics/6_3.png,ave_2,6_3.txt,MAC_Bench/Nature/Cover/Nature Reviews Physics/6_5.png,MAC_Bench/Nature/Cover/Nature Reviews Physics/6_5.png,groundtruth,6_5.txt,train670NATURE METHODS,21_7,Which of the following options best describe the cover story?,"Mapping white matter in chimpanzee671Transverse view of a whole-brain tract-density reconstruction of white matter pathways in the chimpanzee brain. Color indicates tissue orientation and brightness encodes density of reconstructed fiber streamlines.672See Eichner et al.673Image: Cornelius Eichner, Max Planck Institute for Human Cognitive and Brain Sciences. Cover design: Thomas Phillips",D,MAC_Bench/Nature/Cover/NATURE METHODS/21_6.png,MAC_Bench/Nature/Cover/NATURE METHODS/21_6.png,ave_2,21_6.txt,MAC_Bench/Nature/Cover/NATURE METHODS/19_8.png,MAC_Bench/Nature/Cover/NATURE METHODS/19_8.png,clip,19_8.txt,MAC_Bench/Nature/Cover/NATURE METHODS/19_2.png,MAC_Bench/Nature/Cover/NATURE METHODS/19_2.png,ave_3,19_2.txt,MAC_Bench/Nature/Cover/NATURE METHODS/21_7.png,MAC_Bench/Nature/Cover/NATURE METHODS/21_7.png,groundtruth,21_7.txt,val674ACS ES&T Air,2024_6,Which of the following options best describe the cover story?,"With positive matrix factorization techniques, sea spray aerosol can be distinguished from secondary marine aerosol. The cover photo, courtesy of Chaosheng Zhang, shows breaking waves over the west coast of Ireland.",B,MAC_Bench/ACS/Cover/ACS ES&T Air/2024_9.png,MAC_Bench/ACS/Cover/ACS ES&T Air/2024_9.png,ave_3,2024_9.txt,MAC_Bench/ACS/Cover/ACS ES&T Air/2024_6.png,MAC_Bench/ACS/Cover/ACS ES&T Air/2024_6.png,groundtruth,2024_6.txt,MAC_Bench/ACS/Cover/ACS ES&T Air/2025_2.png,MAC_Bench/ACS/Cover/ACS ES&T Air/2025_2.png,vith,2025_2.txt,MAC_Bench/ACS/Cover/ACS ES&T Air/2024_3.png,MAC_Bench/ACS/Cover/ACS ES&T Air/2024_3.png,clip,2024_3.txt,val675Accounts of Chemical Research,2024_14,Which of the following options best describe the cover story?,"In the past, glycan synthesis has been difficult, requiring multi-step manual operations and a highly skilled workforce (at the remote end). Through the time and space tunnel, a donor preactivation-based strategy has enabled glycan synthesis from oligosaccharides to polysaccharides and from manual to automated synthesis, reaching a new height (at the proximal end).",D,MAC_Bench/ACS/Cover/Accounts of Chemical Research/2023_14.png,MAC_Bench/ACS/Cover/Accounts of Chemical Research/2023_14.png,clip,2023_14.txt,MAC_Bench/ACS/Cover/Accounts of Chemical Research/2021_4.png,MAC_Bench/ACS/Cover/Accounts of Chemical Research/2021_4.png,vith,2021_4.txt,MAC_Bench/ACS/Cover/Accounts of Chemical Research/2023_9.png,MAC_Bench/ACS/Cover/Accounts of Chemical Research/2023_9.png,vitg,2023_9.txt,MAC_Bench/ACS/Cover/Accounts of Chemical Research/2024_14.png,MAC_Bench/ACS/Cover/Accounts of Chemical Research/2024_14.png,groundtruth,2024_14.txt,train676Lab Animal,53_9,Which of the following options best describe the cover story?,"In vivo modeling of postpartum hemorrhage677Severe bleeding after childbirth – postpartum haemorrhage (PPH) – is a leading cause of maternal mortality worldwide. Several animal models have been developed for testing novel therapeutic materials; however, these animals differ considerably from the anatomy and physiology of a postpartum woman. In a new Review, Hargett, Leslie et al. critically evaluate available animal models of PPH and propose additional methods for modeling PPH in vivo.678See Gaharwar et al.679Cover image: Debbie Maizels. Cover design: Debbie Maizels.",A,MAC_Bench/Nature/Cover/Lab Animal/53_9.png,MAC_Bench/Nature/Cover/Lab Animal/53_9.png,groundtruth,53_9.txt,MAC_Bench/Nature/Cover/Lab Animal/50_2.png,MAC_Bench/Nature/Cover/Lab Animal/50_2.png,vith,50_2.txt,MAC_Bench/Nature/Cover/Lab Animal/50_6.png,MAC_Bench/Nature/Cover/Lab Animal/50_6.png,vitg,50_6.txt,MAC_Bench/Nature/Cover/Lab Animal/50_9.png,MAC_Bench/Nature/Cover/Lab Animal/50_9.png,clip,50_9.txt,test680Nature Aging,4_12,Which of the following options best describe the cover story?,"Inferring health trajectories681In this issue, Netta Mendelson Cohen et al. investigate individuals’ trajectories of healthy aging and age-related diseases. The researchers stitch together electronic health records with partial longitudinal coverage, using machine learning to untangle future healthy aging from chronic disease, and identify early indicators for healthy longevity. The cover image shows the study’s longevity-model features superimposed with representations of electronic health record information, which are connected via multiple solid or dotted lines that indicate differing propensities to drive the outputs of the models.682See Cohen et al.683Image: adapted from Nat. Aging https://doi.org/10.1038/s43587-023-00536-5 (2024), Springer Nature America (background and central graph), elenabs/iStock/Getty Images Plus (remaining elements). Cover Design: Lauren Heslop",B,MAC_Bench/Nature/Cover/Nature Aging/4_1.png,MAC_Bench/Nature/Cover/Nature Aging/4_1.png,clip,4_1.txt,MAC_Bench/Nature/Cover/Nature Aging/4_12.png,MAC_Bench/Nature/Cover/Nature Aging/4_12.png,groundtruth,4_12.txt,MAC_Bench/Nature/Cover/Nature Aging/4_11.png,MAC_Bench/Nature/Cover/Nature Aging/4_11.png,vitg,4_11.txt,MAC_Bench/Nature/Cover/Nature Aging/1_2.png,MAC_Bench/Nature/Cover/Nature Aging/1_2.png,vith,1_2.txt,train684Trends in Microbiology,32_4,Which of the following options best describe the cover story?,"Stressful environments provide unique ecological niches for microbial685evolution. The cover schematic depicts multiple strategies that bacteriophages686(phages) can adopt to cope with various physicochemical stressors, such as687extreme temperatures, radiation, and toxic pollutants. In this issue, Dan Huang and688colleagues review the impact of various environmental stressors on the physiological689state and community dynamics of phages and explore the adaptive strategies690employed by phages in response to these stressors. They also discuss the ecological691consequences of phage-host interactions within stressful environments. Image692courtesy: Dan Huang",B,MAC_Bench/Cell/Cover/Trends in Microbiology/32_7.png,MAC_Bench/Cell/Cover/Trends in Microbiology/32_7.png,ave_2,32_7.txt,MAC_Bench/Cell/Cover/Trends in Microbiology/32_4.png,MAC_Bench/Cell/Cover/Trends in Microbiology/32_4.png,groundtruth,32_4.txt,MAC_Bench/Cell/Cover/Trends in Microbiology/32_1.png,MAC_Bench/Cell/Cover/Trends in Microbiology/32_1.png,clip,32_1.txt,MAC_Bench/Cell/Cover/Trends in Microbiology/30_9.png,MAC_Bench/Cell/Cover/Trends in Microbiology/30_9.png,vitg,30_9.txt,train693Nature Water,2_5,Which of the following options best describe the cover story?,"Isotope monitoring of river flow dynamics694River flow dynamics, encompassing all interactions and processes that regulate water movements within river systems, are influenced by various factors such as precipitation and land use. Understanding these dynamics is essential for water resource management within ongoing hydroclimate and land-use changes. By analysing stable isotopes in water molecules from rivers globally, Vystavna and colleagues identify the young water fraction (<2−3months) and introduce an indicator of dynamic water retention that shows river flow dynamics are influenced by land use and hydroclimate characteristics. The cover shows the Schlögener Schlinge in the upper Danube valley in Austria, where the Danube almost forms a circle. In large river catchments like the Danube, contributing tributaries exhibit varied catchment and climate characteristics, leading to contrasting trends in young water fraction and dynamic water retention.695See Vystavna et al.696Image: Walter Geiersperger/Corbis Documentary/Getty Images. Cover design: Debbie Maizels",B,MAC_Bench/Nature/Cover/Nature Water/2_10.png,MAC_Bench/Nature/Cover/Nature Water/2_10.png,vitg,2_10.txt,MAC_Bench/Nature/Cover/Nature Water/2_5.png,MAC_Bench/Nature/Cover/Nature Water/2_5.png,groundtruth,2_5.txt,MAC_Bench/Nature/Cover/Nature Water/1_12.png,MAC_Bench/Nature/Cover/Nature Water/1_12.png,ave_3,1_12.txt,MAC_Bench/Nature/Cover/Nature Water/2_3.png,MAC_Bench/Nature/Cover/Nature Water/2_3.png,clip,2_3.txt,val697Trends in Ecology & Evolution,39_10,Which of the following options best describe the cover story?,"Atoll islands, such as Teti'aroa, French Polynesia, pictured here,698are often perceived as inevitably lost due to rising sea levels. On pages 258–266,699Sebastian Steibl and colleagues argue for protecting and restoring the processes of700atoll island accretion. Local conservation actions, along with reductions in greenhouse701gas emissions, are key to unlocking nature-based opportunities for enhancing atoll702resilience to global change. Photo credit: Tetiaroa Society info@tetiaroasociety.org.",A,MAC_Bench/Cell/Cover/Trends in Ecology & Evolution/39_10.png,MAC_Bench/Cell/Cover/Trends in Ecology & Evolution/39_10.png,groundtruth,39_10.txt,MAC_Bench/Cell/Cover/Trends in Ecology & Evolution/38_10.png,MAC_Bench/Cell/Cover/Trends in Ecology & Evolution/38_10.png,vith,38_10.txt,MAC_Bench/Cell/Cover/Trends in Ecology & Evolution/39_8.png,MAC_Bench/Cell/Cover/Trends in Ecology & Evolution/39_8.png,vitg,39_8.txt,MAC_Bench/Cell/Cover/Trends in Ecology & Evolution/39_1.png,MAC_Bench/Cell/Cover/Trends in Ecology & Evolution/39_1.png,clip,39_1.txt,train703Nature Reviews Psychology,3_5,Which of the following options best describe the cover story?,"In this Review, Bell et al. describe current VR-based treatments for mental health conditions and discuss technological and psychological tools that might promote enhanced immersive experiences.704Cover design: David Johnston",C,MAC_Bench/Nature/Cover/Nature Reviews Psychology/3_7.png,MAC_Bench/Nature/Cover/Nature Reviews Psychology/3_7.png,clip,3_7.txt,MAC_Bench/Nature/Cover/Nature Reviews Psychology/2_6.png,MAC_Bench/Nature/Cover/Nature Reviews Psychology/2_6.png,ave_3,2_6.txt,MAC_Bench/Nature/Cover/Nature Reviews Psychology/3_5.png,MAC_Bench/Nature/Cover/Nature Reviews Psychology/3_5.png,groundtruth,3_5.txt,MAC_Bench/Nature/Cover/Nature Reviews Psychology/3_6.png,MAC_Bench/Nature/Cover/Nature Reviews Psychology/3_6.png,ave_2,3_6.txt,train705Nature Chemistry,16_12,Which of the following options best describe the cover story?,"Identifying an elusive intermediate706Trans–cis photoisomerization plays an essential role in various biological settings such as vision, ion pumping, and light sensing. The prototypical trans–cis photoisomerization of stilbenes (an artistic impression of which is depicted on the cover) is thought to occur via an intermediate with a perpendicular conformation; however, its unambiguous identification has thus far proved difficult. Using ultrafast Raman spectroscopy and ab initio molecular dynamics simulations, Tahei Tahara and colleagues now characterize the common, perpendicular intermediate of stilbene photoisomerization, revealing its ultrafast birth and decay upon photoexcitation of the trans and cis forms.707See Kuramochi et al.708Image: Takaya Fukui, Art Action Inc.. Cover design: Tulsi Voralia",D,MAC_Bench/Nature/Cover/Nature Chemistry/13_7.png,MAC_Bench/Nature/Cover/Nature Chemistry/13_7.png,vith,13_7.txt,MAC_Bench/Nature/Cover/Nature Chemistry/14_2.png,MAC_Bench/Nature/Cover/Nature Chemistry/14_2.png,vitg,14_2.txt,MAC_Bench/Nature/Cover/Nature Chemistry/14_6.png,MAC_Bench/Nature/Cover/Nature Chemistry/14_6.png,clip,14_6.txt,MAC_Bench/Nature/Cover/Nature Chemistry/16_12.png,MAC_Bench/Nature/Cover/Nature Chemistry/16_12.png,groundtruth,16_12.txt,train709One Earth,7_12,Which of the following options best describe the cover story?,"On the cover: Scientific journals can play an important role in the curation and communication710of key scientific advances and expert opinions. But as the scientific literature and711number of publication platforms continue to expand, it can be easy to lose sight of712these important functions. Image: Eoneren, Getty.",A,MAC_Bench/Cell/Cover/One Earth/7_12.png,MAC_Bench/Cell/Cover/One Earth/7_12.png,groundtruth,7_12.txt,MAC_Bench/Cell/Cover/One Earth/7_1.png,MAC_Bench/Cell/Cover/One Earth/7_1.png,clip,7_1.txt,MAC_Bench/Cell/Cover/One Earth/5_1.png,MAC_Bench/Cell/Cover/One Earth/5_1.png,vith,5_1.txt,MAC_Bench/Cell/Cover/One Earth/7_10.png,MAC_Bench/Cell/Cover/One Earth/7_10.png,ave_2,7_10.txt,train713NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY,21_5,Which of the following options best describe the cover story?,"Artificial intelligence in liver cancer, inspired by the Perspective on p585.714Cover design: Laura Marshall",A,MAC_Bench/Nature/Cover/NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY/21_5.png,MAC_Bench/Nature/Cover/NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY/21_5.png,groundtruth,21_5.txt,MAC_Bench/Nature/Cover/NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY/20_4.png,MAC_Bench/Nature/Cover/NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY/20_4.png,clip,20_4.txt,MAC_Bench/Nature/Cover/NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY/21_6.png,MAC_Bench/Nature/Cover/NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY/21_6.png,vitg,21_6.txt,MAC_Bench/Nature/Cover/NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY/21_12.png,MAC_Bench/Nature/Cover/NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY/21_12.png,vith,21_12.txt,train715The Journal of Physical Chemistry A,2025_6,Which of the following options best describe the cover story?,"This cover feature depicts the immobilization of a [Ru(bpy)2(nicotine)2](Cl)2 (Ru-nico) complex from the aqueous solution to a polymer film. The Ru-nico complex in aqueous solution and rigid media, such as poly(methyl-methacrylate) (PMMA) and polyacrylonitrile (PAN) polymer films, were subjected to ultrafast transient absorption and emission studies. The findings provide ligand dissociation dynamics of the Ru-nico complex as the nicotine ligand gradually detaches from the Ru ion in solution, whereas this dissociation is inhibited in polymer films. This restricted ligand dissociation in films results in an emissive and long-lived state of Ru-nico in comparison to a nonemissive and short-lived state in solution. Cover design by Mohini Semwal and Ratnadip De.",D,MAC_Bench/ACS/Cover/The Journal of Physical Chemistry A/2025_1.png,MAC_Bench/ACS/Cover/The Journal of Physical Chemistry A/2025_1.png,clip,2025_1.txt,MAC_Bench/ACS/Cover/The Journal of Physical Chemistry A/2023_5.png,MAC_Bench/ACS/Cover/The Journal of Physical Chemistry A/2023_5.png,ave_3,2023_5.txt,MAC_Bench/ACS/Cover/The Journal of Physical Chemistry A/2024_41.png,MAC_Bench/ACS/Cover/The Journal of Physical Chemistry A/2024_41.png,ave_2,2024_41.txt,MAC_Bench/ACS/Cover/The Journal of Physical Chemistry A/2025_6.png,MAC_Bench/ACS/Cover/The Journal of Physical Chemistry A/2025_6.png,groundtruth,2025_6.txt,train716ACS Synthetic Biology,2024_3,Which of the following options best describe the cover story?,Engineering living material for fragrance release. View the article.,C,MAC_Bench/ACS/Cover/ACS Synthetic Biology/2022_12.png,MAC_Bench/ACS/Cover/ACS Synthetic Biology/2022_12.png,vith,2022_12.txt,MAC_Bench/ACS/Cover/ACS Synthetic Biology/2024_4.png,MAC_Bench/ACS/Cover/ACS Synthetic Biology/2024_4.png,clip,2024_4.txt,MAC_Bench/ACS/Cover/ACS Synthetic Biology/2024_3.png,MAC_Bench/ACS/Cover/ACS Synthetic Biology/2024_3.png,groundtruth,2024_3.txt,MAC_Bench/ACS/Cover/ACS Synthetic Biology/2025_1.png,MAC_Bench/ACS/Cover/ACS Synthetic Biology/2025_1.png,vitg,2025_1.txt,train717CHEMICAL REVIEWS,2025_1,Which of the following options best describe the cover story?,"Illustration of an electrochemical random access memory (ECRAM) that functions by moving mobile defects, such as protons, lithium ions, or oxygen vacancies, between the top (reservoir) and bottom (channel) electrodes made of various functional materials and connected by a solid electrolyte (middle, light blue). The mobile defects tune the electronic conductance through reversible redox reactions. Although ECRAM shares many fundamental aspects with rechargeable batteries, computing applications require many millions of devices, scaled down to sub-micrometer dimensions, while achieving reliable electronic-state tuning at scaled-up rates and endurances and with minimal energy dissipation.",C,MAC_Bench/ACS/Cover/CHEMICAL REVIEWS/2019_5.png,MAC_Bench/ACS/Cover/CHEMICAL REVIEWS/2019_5.png,vitg,2019_5.txt,MAC_Bench/ACS/Cover/CHEMICAL REVIEWS/2019_19.png,MAC_Bench/ACS/Cover/CHEMICAL REVIEWS/2019_19.png,clip,2019_19.txt,MAC_Bench/ACS/Cover/CHEMICAL REVIEWS/2025_1.png,MAC_Bench/ACS/Cover/CHEMICAL REVIEWS/2025_1.png,groundtruth,2025_1.txt,MAC_Bench/ACS/Cover/CHEMICAL REVIEWS/2016_2.png,MAC_Bench/ACS/Cover/CHEMICAL REVIEWS/2016_2.png,vith,2016_2.txt,test718ACS Applied Electronic Materials,2025_1,Which of the following options best describe the cover story?,Two-dimensional (2D) materials-coated paper-based helical origami triboelectric nanogenerators (O-TENGs) are designed to harvest blue energy. The efficient charge transfer between the cellulose and 2D materials significantly improves the output performance of the O-TENGs. This,B,MAC_Bench/ACS/Cover/ACS Applied Electronic Materials/2022_6.png,MAC_Bench/ACS/Cover/ACS Applied Electronic Materials/2022_6.png,clip,2022_6.txt,MAC_Bench/ACS/Cover/ACS Applied Electronic Materials/2025_1.png,MAC_Bench/ACS/Cover/ACS Applied Electronic Materials/2025_1.png,groundtruth,2025_1.txt,MAC_Bench/ACS/Cover/ACS Applied Electronic Materials/2019_3.png,MAC_Bench/ACS/Cover/ACS Applied Electronic Materials/2019_3.png,vith,2019_3.txt,MAC_Bench/ACS/Cover/ACS Applied Electronic Materials/2022_12.png,MAC_Bench/ACS/Cover/ACS Applied Electronic Materials/2022_12.png,vitg,2022_12.txt,train719NATURE REVIEWS MOLECULAR CELL BIOLOGY,25_10,Which of the following options best describe the cover story?,"‘Making synthetic cells’, inspired by the Comment on p157 and Viewpoint on p162.720Cover design: Vicky Summersby.",A,MAC_Bench/Nature/Cover/NATURE REVIEWS MOLECULAR CELL BIOLOGY/25_10.png,MAC_Bench/Nature/Cover/NATURE REVIEWS MOLECULAR CELL BIOLOGY/25_10.png,groundtruth,25_10.txt,MAC_Bench/Nature/Cover/NATURE REVIEWS MOLECULAR CELL BIOLOGY/25_9.png,MAC_Bench/Nature/Cover/NATURE REVIEWS MOLECULAR CELL BIOLOGY/25_9.png,clip,25_9.txt,MAC_Bench/Nature/Cover/NATURE REVIEWS MOLECULAR CELL BIOLOGY/25_4.png,MAC_Bench/Nature/Cover/NATURE REVIEWS MOLECULAR CELL BIOLOGY/25_4.png,ave_2,25_4.txt,MAC_Bench/Nature/Cover/NATURE REVIEWS MOLECULAR CELL BIOLOGY/25_3.png,MAC_Bench/Nature/Cover/NATURE REVIEWS MOLECULAR CELL BIOLOGY/25_3.png,ave_3,25_3.txt,val721Nature Metabolism,6_4,Which of the following options best describe the cover story?,"Spatial lipid fluxes72213C-SpaceM combines stable isotope tracing with imaging mass spectrometry thus enabling spatial analysis of lipid dynamics with near single-cell resolution in tissues. The illustration is a photo of a cross-stitch embroidery with a part of the imaging mass spectrometry heatmap used as a scheme. Loose threads outside of the hoop symbolize the metabolic fluxes studied in this manuscript.723See Buglakova et al.724Image: Elena Buglakova, EMBL (embroidery); Massimo Del Prete, EMBL (photo). Cover design: Thomas Phillips",A,MAC_Bench/Nature/Cover/Nature Metabolism/6_4.png,MAC_Bench/Nature/Cover/Nature Metabolism/6_4.png,groundtruth,6_4.txt,MAC_Bench/Nature/Cover/Nature Metabolism/2_12.png,MAC_Bench/Nature/Cover/Nature Metabolism/2_12.png,clip,2_12.txt,MAC_Bench/Nature/Cover/Nature Metabolism/4_6.png,MAC_Bench/Nature/Cover/Nature Metabolism/4_6.png,ave_3,4_6.txt,MAC_Bench/Nature/Cover/Nature Metabolism/3_12.png,MAC_Bench/Nature/Cover/Nature Metabolism/3_12.png,vitg,3_12.txt,train725Journal of Chemical Education,2021_11,Which of the following options best describe the cover story?,"–and demonstrates redox chemistry that allows for the direct conversion of chemical energy to mechanical energy without involving a machine to accomplish the transfer. The visual effect is mesmerizing and provides a compelling introduction to the rich underlying science; however, the difficulty and time required to initiate and maintain regular oscillations often frustrates instructors and students, discouraging many from presenting this demonstration. In ""Resuscitating the Mercury Beating Heart: An Improvement on the Classic Demo"" (DOI: 10.1021/acs.jchemed.0c00845), Daniel Stribling, Christopher R. Brewer, and Kenneth A. Goldsby describe a simple device for reducing the setup time and increasing the duration of this classic yet underutilized chemical demonstration.",C,MAC_Bench/ACS/Cover/Journal of Chemical Education/2012_5.png,MAC_Bench/ACS/Cover/Journal of Chemical Education/2012_5.png,clip,2012_5.txt,MAC_Bench/ACS/Cover/Journal of Chemical Education/2019_11.png,MAC_Bench/ACS/Cover/Journal of Chemical Education/2019_11.png,vitg,2019_11.txt,MAC_Bench/ACS/Cover/Journal of Chemical Education/2021_11.png,MAC_Bench/ACS/Cover/Journal of Chemical Education/2021_11.png,groundtruth,2021_11.txt,MAC_Bench/ACS/Cover/Journal of Chemical Education/2018_1.png,MAC_Bench/ACS/Cover/Journal of Chemical Education/2018_1.png,vith,2018_1.txt,train726Joule,8_3,Which of the following options best describe the cover story?,"On the cover: The cover image features an all-solid-state battery (ASSB) incorporating727an FeSn2 anode, a LiNi0.6Co0.2Mn0.2O2 (NCM622) cathode, and a Li6PS5Cl solid electrolyte placed on an electronic circuit. The continents of the Earth728are illuminated by the energy generated from this high-energy-density ASSB, symbolizing729its potential to revolutionize global energy storage and utilization. As demonstrated730by Lee et al., this ASSB exhibits exceptional performance, stability, and energy efficiency, emphasizing731its crucial role in advancing sustainable energy for the future. This pioneering research732highlights the potential of FeSn2 anodes to enhance the overall performance and safety of ASSBs, driving innovation733in energy storage technology. Artist/image source: Suk-Woo Yoon (SCIART 3D GRAPHIC734in Republic of Korea).",B,MAC_Bench/Cell/Cover/Joule/5_10.png,MAC_Bench/Cell/Cover/Joule/5_10.png,vith,5_10.txt,MAC_Bench/Cell/Cover/Joule/8_3.png,MAC_Bench/Cell/Cover/Joule/8_3.png,groundtruth,8_3.txt,MAC_Bench/Cell/Cover/Joule/7_6.png,MAC_Bench/Cell/Cover/Joule/7_6.png,vitg,7_6.txt,MAC_Bench/Cell/Cover/Joule/8_4.png,MAC_Bench/Cell/Cover/Joule/8_4.png,clip,8_4.txt,train735Nature Reviews Chemistry,8_9,Which of the following options best describe the cover story?,"Upconversion enables the energy of two long wavelength photons to be combined, resulting in photoexcitation that would otherwise require a single short wavelength photon. Longer wavelength photons penetrate more deeply and so upconversion is especially useful for phototherapy and applications of photochemical reactions on a large scale. This process is shown on the cover where a green target absorbs two red incident rays and emits a single blue ray. See Huang et al.736Cover design: Carl Conway",B,MAC_Bench/Nature/Cover/Nature Reviews Chemistry/7_2.png,MAC_Bench/Nature/Cover/Nature Reviews Chemistry/7_2.png,ave_2,7_2.txt,MAC_Bench/Nature/Cover/Nature Reviews Chemistry/8_9.png,MAC_Bench/Nature/Cover/Nature Reviews Chemistry/8_9.png,groundtruth,8_9.txt,MAC_Bench/Nature/Cover/Nature Reviews Chemistry/8_2.png,MAC_Bench/Nature/Cover/Nature Reviews Chemistry/8_2.png,ave_3,8_2.txt,MAC_Bench/Nature/Cover/Nature Reviews Chemistry/8_10.png,MAC_Bench/Nature/Cover/Nature Reviews Chemistry/8_10.png,clip,8_10.txt,val737Nature Water,3_1,Which of the following options best describe the cover story?,"An all-water mission738Water observing and monitoring, both ground-based and space-based, are essential for understanding the water cycle and managing water resources. A recently launched space observatory, called the Surface Water and Ocean Topography (SWOT) satellite provides direct, high-resolution measurements of water elevation and volume across various water bodies, including open and coastal oceans (shown as coloured sea surface height anomalies), as well as lakes and rivers (displayed as water surface elevations), making it a truly comprehensive surface water mission. The image shows a snapshot of Earth’s surface water elevation from the SWOT satellite mission during its inaugural science orbit. Fully validated data is now publicly available for scientists to study changing water and energy cycles and for users to manage water resources worldwide.739See Vinogradova et al.740Image: NASA. Cover design: Laoise Mac Gabhann",C,MAC_Bench/Nature/Cover/Nature Water/2_6.png,MAC_Bench/Nature/Cover/Nature Water/2_6.png,clip,2_6.txt,MAC_Bench/Nature/Cover/Nature Water/1_2.png,MAC_Bench/Nature/Cover/Nature Water/1_2.png,vith,1_2.txt,MAC_Bench/Nature/Cover/Nature Water/3_1.png,MAC_Bench/Nature/Cover/Nature Water/3_1.png,groundtruth,3_1.txt,MAC_Bench/Nature/Cover/Nature Water/2_7.png,MAC_Bench/Nature/Cover/Nature Water/2_7.png,vitg,2_7.txt,train741Med,5_10,Which of the following options best describe the cover story?,"On the cover: While psilocybin-assisted psychotherapy (PAP) has shown promise in treating742depression, previous studies often excluded people with complex presentations. In743this issue of Med, Rosenblat et al. aimed to determine whether PAP could be feasible and beneficial in complex cases744of treatment-resistant depression as part of major depressive or bipolar II disorder745without psychosis or a substance use disorder, and those with baseline suicidality746and significant comorbidity. The authors found PAP to be safe and effective, and repeated747doses showed stronger benefits, suggesting further research is warranted to explore748this treatment option for harder-to-treat populations. Cover art from PM Images/Stone749via Getty Images.",C,MAC_Bench/Cell/Cover/Med/2_1.png,MAC_Bench/Cell/Cover/Med/2_1.png,vith,2_1.txt,MAC_Bench/Cell/Cover/Med/5_8.png,MAC_Bench/Cell/Cover/Med/5_8.png,clip,5_8.txt,MAC_Bench/Cell/Cover/Med/5_10.png,MAC_Bench/Cell/Cover/Med/5_10.png,groundtruth,5_10.txt,MAC_Bench/Cell/Cover/Med/5_1.png,MAC_Bench/Cell/Cover/Med/5_1.png,vitg,5_1.txt,train750ACS Catalysis,2024_23,Which of the following options best describe the cover story?,"Diverse single-atom metal catalysts emerge and stimulate a new pulse in the coal-based PVC industry, which is heavily relying on the prohibited mercury chloride analogues. The synthetic strategies, structure–performance relationships, and reaction mechanisms of these frontiers are reviewed.",D,MAC_Bench/ACS/Cover/ACS Catalysis/2024_12.png,MAC_Bench/ACS/Cover/ACS Catalysis/2024_12.png,vitg,2024_12.txt,MAC_Bench/ACS/Cover/ACS Catalysis/2022_1.png,MAC_Bench/ACS/Cover/ACS Catalysis/2022_1.png,clip,2022_1.txt,MAC_Bench/ACS/Cover/ACS Catalysis/2022_17.png,MAC_Bench/ACS/Cover/ACS Catalysis/2022_17.png,vith,2022_17.txt,MAC_Bench/ACS/Cover/ACS Catalysis/2024_23.png,MAC_Bench/ACS/Cover/ACS Catalysis/2024_23.png,groundtruth,2024_23.txt,test751Trends in Cancer,10_9,Which of the following options best describe the cover story?,"In the evolving era of cancer immunotherapy, combination strategies752are becoming ever more effective in overcoming challenges associated with PD-1753monotherapy. In this issue, Hashimoto et al. discuss the potential of PD-1/IL-2754combination regimen in enhancing anti-cancer therapy efficacy through shaping the755differentiation trajectory of CD8 T cells, thereby impacting their exhaustion program.756The cover depicts an effector CD8 T cell (upper right), generated by PD-1 blockade757and758IL-2 therapy, effectively finding and killing malignant cells (lower left). The cover759image760was created by Mie Yoshimura.",C,MAC_Bench/Cell/Cover/Trends in Cancer/9_2.png,MAC_Bench/Cell/Cover/Trends in Cancer/9_2.png,clip,9_2.txt,MAC_Bench/Cell/Cover/Trends in Cancer/9_4.png,MAC_Bench/Cell/Cover/Trends in Cancer/9_4.png,vitg,9_4.txt,MAC_Bench/Cell/Cover/Trends in Cancer/10_9.png,MAC_Bench/Cell/Cover/Trends in Cancer/10_9.png,groundtruth,10_9.txt,MAC_Bench/Cell/Cover/Trends in Cancer/10_7.png,MAC_Bench/Cell/Cover/Trends in Cancer/10_7.png,ave_2,10_7.txt,test761NATURE METHODS,21_3,Which of the following options best describe the cover story?,"20 years of Nature Methods762This month, Nature Methods celebrates its 20th anniversary with a special feature.763See Editorial764Image: Thomas Phillips, Springer Nature. Cover design: Thomas Phillips",B,MAC_Bench/Nature/Cover/NATURE METHODS/22_1.png,MAC_Bench/Nature/Cover/NATURE METHODS/22_1.png,ave_3,22_1.txt,MAC_Bench/Nature/Cover/NATURE METHODS/21_3.png,MAC_Bench/Nature/Cover/NATURE METHODS/21_3.png,groundtruth,21_3.txt,MAC_Bench/Nature/Cover/NATURE METHODS/20_10.png,MAC_Bench/Nature/Cover/NATURE METHODS/20_10.png,clip,20_10.txt,MAC_Bench/Nature/Cover/NATURE METHODS/20_7.png,MAC_Bench/Nature/Cover/NATURE METHODS/20_7.png,vitg,20_7.txt,train765ACS Chemical Biology,2024_9,Which of the following options best describe the cover story?,"Cancer cells showed an incredible adaptive tumor response to the inhibition of the sequentially mutated EGFR, triggering the need of designing novel mutant-selective TKIs.",C,MAC_Bench/ACS/Cover/ACS Chemical Biology/2023_5.png,MAC_Bench/ACS/Cover/ACS Chemical Biology/2023_5.png,vith,2023_5.txt,MAC_Bench/ACS/Cover/ACS Chemical Biology/2023_2.png,MAC_Bench/ACS/Cover/ACS Chemical Biology/2023_2.png,clip,2023_2.txt,MAC_Bench/ACS/Cover/ACS Chemical Biology/2024_9.png,MAC_Bench/ACS/Cover/ACS Chemical Biology/2024_9.png,groundtruth,2024_9.txt,MAC_Bench/ACS/Cover/ACS Chemical Biology/2022_6.png,MAC_Bench/ACS/Cover/ACS Chemical Biology/2022_6.png,vitg,2022_6.txt,train766Nature Reviews Chemistry,8_2,Which of the following options best describe the cover story?,"The depolymerization of lignin is represented by a wooden block at the centre of the image surrounded by the products of breakdown and catalysts that have been applied in this important biomass valorization reaction. Lignin is a heterogeneous aromatic macromolecule found in the cell walls of plants. Its conversion to useful monomers is considered key to a transition away from fossil fuel feedstocks. Although there has been much research into C-O cleavage, commercial use of a far greater proportion of available lignin requires cleavage of C-C bonds, which has proven particularly challenging both to develop and to quantify, see Palumbo et al.767Image: Rita Clare; Cover design: Carl Conway",D,MAC_Bench/Nature/Cover/Nature Reviews Chemistry/8_10.png,MAC_Bench/Nature/Cover/Nature Reviews Chemistry/8_10.png,ave_3,8_10.txt,MAC_Bench/Nature/Cover/Nature Reviews Chemistry/8_1.png,MAC_Bench/Nature/Cover/Nature Reviews Chemistry/8_1.png,vith,8_1.txt,MAC_Bench/Nature/Cover/Nature Reviews Chemistry/8_3.png,MAC_Bench/Nature/Cover/Nature Reviews Chemistry/8_3.png,clip,8_3.txt,MAC_Bench/Nature/Cover/Nature Reviews Chemistry/8_2.png,MAC_Bench/Nature/Cover/Nature Reviews Chemistry/8_2.png,groundtruth,8_2.txt,train768ACS Macro Letters,2024_3,Which of the following options best describe the cover story?,"Immiscible linear polymers (yellow vs blue) with diblock ring polymers at the interface under large shear deformation. A diblock ring threaded by two linear polymers from opposite sides is highlighted, demonstrating an adhesion mechanism analogous to the hook-and-loop process in Velcro tapes.",C,MAC_Bench/ACS/Cover/ACS Macro Letters/2024_8.png,MAC_Bench/ACS/Cover/ACS Macro Letters/2024_8.png,ave_2,2024_8.txt,MAC_Bench/ACS/Cover/ACS Macro Letters/2024_11.png,MAC_Bench/ACS/Cover/ACS Macro Letters/2024_11.png,clip,2024_11.txt,MAC_Bench/ACS/Cover/ACS Macro Letters/2024_3.png,MAC_Bench/ACS/Cover/ACS Macro Letters/2024_3.png,groundtruth,2024_3.txt,MAC_Bench/ACS/Cover/ACS Macro Letters/2016_9.png,MAC_Bench/ACS/Cover/ACS Macro Letters/2016_9.png,ave_3,2016_9.txt,train769Molecular Pharmaceutics,2024_3,Which of the following options best describe the cover story?,Representation of the disordering effect induced by dibasic calcium phosphate (~the wrecking ball; CSD 31046-I) on carbamazepine dihydrate (~the wall; FEFNOT03) leading to its accelerated dehydration (~expelling of water molecules) during the mixing stage of continuous tablet manufacturing. This work focuses on understanding the mechanism of this excipient-induced effect. The image was created by PfizerWorks Creative Consultancy.,D,MAC_Bench/ACS/Cover/Molecular Pharmaceutics/2024_8.png,MAC_Bench/ACS/Cover/Molecular Pharmaceutics/2024_8.png,ave_2,2024_8.txt,MAC_Bench/ACS/Cover/Molecular Pharmaceutics/2021_3.png,MAC_Bench/ACS/Cover/Molecular Pharmaceutics/2021_3.png,clip,2021_3.txt,MAC_Bench/ACS/Cover/Molecular Pharmaceutics/2025_3.png,MAC_Bench/ACS/Cover/Molecular Pharmaceutics/2025_3.png,vith,2025_3.txt,MAC_Bench/ACS/Cover/Molecular Pharmaceutics/2024_3.png,MAC_Bench/ACS/Cover/Molecular Pharmaceutics/2024_3.png,groundtruth,2024_3.txt,train770ACS Synthetic Biology,2024_7,Which of the following options best describe the cover story?,"mediated gene silencing in Chlamydomonas reinhardtii: a cross-sectional view of C. reinhardtii highlights the precise interaction between DNA strands and gold nanoparticles, facilitated by a targeted LED light source. The illustration depicts the subsequent accumulation of lipid droplets indicative of silenced gene expression within the cell.",A,MAC_Bench/ACS/Cover/ACS Synthetic Biology/2024_7.png,MAC_Bench/ACS/Cover/ACS Synthetic Biology/2024_7.png,groundtruth,2024_7.txt,MAC_Bench/ACS/Cover/ACS Synthetic Biology/2025_1.png,MAC_Bench/ACS/Cover/ACS Synthetic Biology/2025_1.png,ave_2,2025_1.txt,MAC_Bench/ACS/Cover/ACS Synthetic Biology/2022_12.png,MAC_Bench/ACS/Cover/ACS Synthetic Biology/2022_12.png,ave_3,2022_12.txt,MAC_Bench/ACS/Cover/ACS Synthetic Biology/2023_6.png,MAC_Bench/ACS/Cover/ACS Synthetic Biology/2023_6.png,clip,2023_6.txt,train771Nature Neuroscience,27_11,Which of the following options best describe the cover story?,"Mothers’ neuroplasticity at peripartum and childbirth.772During gestation, childbirth, and the postpartum period, dynamic cortical plasticity occurs in mothers’ brains. Paternina-Die, Martínez-García et al. show decreased cortical thickness during pregnancy, which attenuates after birth. In the cover image, the mantle enveloping the mother with child symbolizes the cortical mantle, and the shape of the woman’s brain resembles a baby, serving as a metaphor for the maternal brain. The pixelation overlaying the baby and the background recreates the MRI voxels. The central figure in the image portrays Dr Paternina-Die, who herself became a first-time mother during the completion of this study.773See Paternina-Die, Martínez-García, et al.774Image and cover design: Susana Carmona. Cover Design: Marina Corral Spence.",D,MAC_Bench/Nature/Cover/Nature Neuroscience/25_10.png,MAC_Bench/Nature/Cover/Nature Neuroscience/25_10.png,clip,25_10.txt,MAC_Bench/Nature/Cover/Nature Neuroscience/27_4.png,MAC_Bench/Nature/Cover/Nature Neuroscience/27_4.png,vitg,27_4.txt,MAC_Bench/Nature/Cover/Nature Neuroscience/25_5.png,MAC_Bench/Nature/Cover/Nature Neuroscience/25_5.png,ave_1,25_5.txt,MAC_Bench/Nature/Cover/Nature Neuroscience/27_11.png,MAC_Bench/Nature/Cover/Nature Neuroscience/27_11.png,groundtruth,27_11.txt,train775NATURE MEDICINE,30_10,Which of the following options best describe the cover story?,"Pancreatic cancer biomarkers776In this issue, Shi, Jin, Yin, Fang, Chen, Shen and colleagues use proteomic data to identify biomarkers of the response to adjuvant chemotherapy and develop a prognostic risk model for patients with pancreatic ductal adenocarcinoma. The cover depicts a pancreas compass with the needles symbolizing biomarkers, illustrating the potential for optimizing treatment management for patients with pancreatic cancer.777See Jiang et al.778Image: Baiyong Shen, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine. Cover design: Debbie Maizels",C,MAC_Bench/Nature/Cover/NATURE MEDICINE/28_8.png,MAC_Bench/Nature/Cover/NATURE MEDICINE/28_8.png,clip,28_8.txt,MAC_Bench/Nature/Cover/NATURE MEDICINE/30_7.png,MAC_Bench/Nature/Cover/NATURE MEDICINE/30_7.png,vitg,30_7.txt,MAC_Bench/Nature/Cover/NATURE MEDICINE/30_10.png,MAC_Bench/Nature/Cover/NATURE MEDICINE/30_10.png,groundtruth,30_10.txt,MAC_Bench/Nature/Cover/NATURE MEDICINE/30_8.png,MAC_Bench/Nature/Cover/NATURE MEDICINE/30_8.png,ave_2,30_8.txt,train779Cell Reports Methods,4_3,Which of the following options best describe the cover story?,"On the cover: In this issue, Quarles et al. present a method for high-throughput cryosectioning of hundreds of C. elegans in a single block, enabling improved access to antigens for immunostaining. As shown780in the cover image, they use this method to establish C. elegans as a multicellular model for studying the function of inorganic polyphosphate (depicted781in green). Image courtesy of Ellen Quarles.",C,MAC_Bench/Cell/Cover/Cell Reports Methods/4_1.png,MAC_Bench/Cell/Cover/Cell Reports Methods/4_1.png,clip,4_1.txt,MAC_Bench/Cell/Cover/Cell Reports Methods/4_6.png,MAC_Bench/Cell/Cover/Cell Reports Methods/4_6.png,vith,4_6.txt,MAC_Bench/Cell/Cover/Cell Reports Methods/4_3.png,MAC_Bench/Cell/Cover/Cell Reports Methods/4_3.png,groundtruth,4_3.txt,MAC_Bench/Cell/Cover/Cell Reports Methods/4_7.png,MAC_Bench/Cell/Cover/Cell Reports Methods/4_7.png,vitg,4_7.txt,val782NATURE REVIEWS MICROBIOLOGY,22_10,Which of the following options best describe the cover story?,"Honeybee gut microbiota, inspired by the Review on p122.783Cover design: Philip Patenall.",D,MAC_Bench/Nature/Cover/NATURE REVIEWS MICROBIOLOGY/22_8.png,MAC_Bench/Nature/Cover/NATURE REVIEWS MICROBIOLOGY/22_8.png,vitg,22_8.txt,MAC_Bench/Nature/Cover/NATURE REVIEWS MICROBIOLOGY/21_8.png,MAC_Bench/Nature/Cover/NATURE REVIEWS MICROBIOLOGY/21_8.png,ave_3,21_8.txt,MAC_Bench/Nature/Cover/NATURE REVIEWS MICROBIOLOGY/22_9.png,MAC_Bench/Nature/Cover/NATURE REVIEWS MICROBIOLOGY/22_9.png,clip,22_9.txt,MAC_Bench/Nature/Cover/NATURE REVIEWS MICROBIOLOGY/22_10.png,MAC_Bench/Nature/Cover/NATURE REVIEWS MICROBIOLOGY/22_10.png,groundtruth,22_10.txt,train784Nature Neuroscience,27_3,Which of the following options best describe the cover story?,"AI framework for neural–behavioral modeling785Neural dynamics are complex and simultaneously relate to distinct behaviors. To address these challenges, Sani et al. have developed an AI framework termed DPAD that achieves nonlinear dynamical modeling of neural–behavioral data, dissociates behaviorally relevant neural dynamics, and localizes the source of nonlinearity in the dynamical model. In the cover image, what DPAD does is visualized as separating the ovsubbed erall brain activity into distinct pieces related to specific behaviors and discovering how these pieces fit together to build the overall activity.786See Sani et al.787Image: Ella Maru Studio, Omid Sani, Maryam Shanechi. Cover design: Marina Spence",D,MAC_Bench/Nature/Cover/Nature Neuroscience/25_9.png,MAC_Bench/Nature/Cover/Nature Neuroscience/25_9.png,clip,25_9.txt,MAC_Bench/Nature/Cover/Nature Neuroscience/26_10.png,MAC_Bench/Nature/Cover/Nature Neuroscience/26_10.png,ave_2,26_10.txt,MAC_Bench/Nature/Cover/Nature Neuroscience/26_1.png,MAC_Bench/Nature/Cover/Nature Neuroscience/26_1.png,vitg,26_1.txt,MAC_Bench/Nature/Cover/Nature Neuroscience/27_3.png,MAC_Bench/Nature/Cover/Nature Neuroscience/27_3.png,groundtruth,27_3.txt,train788Trends in Immunology,45_12,Which of the following options best describe the cover story?,"The image is a photograph of Eptesicus fuscus (big brown bat). A789couple of articles in this issue discuss the importance of better understanding790bat immunity to elucidate bat–human host interactions, extrapolate knowledge791of bat immunity to that of humans, as well as the translational potential of these792comparisons. Mossman and colleagues review the spillover of viruses from bats to793humans and the novel technologies discerning the factors driving virus and host coevolution;794Banerjee and colleagues propose that research in bat immunity can lead795to translational approaches to improve human health. Image credit: Brock Fenton796and Sherri Fenton.",B,MAC_Bench/Cell/Cover/Trends in Immunology/41_12.png,MAC_Bench/Cell/Cover/Trends in Immunology/41_12.png,clip,41_12.txt,MAC_Bench/Cell/Cover/Trends in Immunology/45_12.png,MAC_Bench/Cell/Cover/Trends in Immunology/45_12.png,groundtruth,45_12.txt,MAC_Bench/Cell/Cover/Trends in Immunology/44_9.png,MAC_Bench/Cell/Cover/Trends in Immunology/44_9.png,vitg,44_9.txt,MAC_Bench/Cell/Cover/Trends in Immunology/45_11.png,MAC_Bench/Cell/Cover/Trends in Immunology/45_11.png,vith,45_11.txt,train797Nature Synthesis,3_5,Which of the following options best describe the cover story?,"Enzymatic C(sp 3)–F bond formation798Enantioselective C(sp 3)–F bond formation is reported using an engineered non-haem iron enzyme. The process proceeds through a radical fluorine atom transfer pathway, which converts N-fluoroamides into chiral benzyl fluorides.799See Zhao et al.800Image: Yunfang Yang, Zhejiang University of Technology. Cover design: Emily Paul",A,MAC_Bench/Nature/Cover/Nature Synthesis/3_5.png,MAC_Bench/Nature/Cover/Nature Synthesis/3_5.png,groundtruth,3_5.txt,MAC_Bench/Nature/Cover/Nature Synthesis/1_4.png,MAC_Bench/Nature/Cover/Nature Synthesis/1_4.png,clip,1_4.txt,MAC_Bench/Nature/Cover/Nature Synthesis/2_2.png,MAC_Bench/Nature/Cover/Nature Synthesis/2_2.png,ave_3,2_2.txt,MAC_Bench/Nature/Cover/Nature Synthesis/2_8.png,MAC_Bench/Nature/Cover/Nature Synthesis/2_8.png,ave_2,2_8.txt,val801NATURE REVIEWS MICROBIOLOGY,22_12,Which of the following options best describe the cover story?,"Disinfection, inspired by the Review on p4.802Cover design: Philip Patenall.",D,MAC_Bench/Nature/Cover/NATURE REVIEWS MICROBIOLOGY/22_6.png,MAC_Bench/Nature/Cover/NATURE REVIEWS MICROBIOLOGY/22_6.png,vitg,22_6.txt,MAC_Bench/Nature/Cover/NATURE REVIEWS MICROBIOLOGY/22_1.png,MAC_Bench/Nature/Cover/NATURE REVIEWS MICROBIOLOGY/22_1.png,vith,22_1.txt,MAC_Bench/Nature/Cover/NATURE REVIEWS MICROBIOLOGY/21_1.png,MAC_Bench/Nature/Cover/NATURE REVIEWS MICROBIOLOGY/21_1.png,clip,21_1.txt,MAC_Bench/Nature/Cover/NATURE REVIEWS MICROBIOLOGY/22_12.png,MAC_Bench/Nature/Cover/NATURE REVIEWS MICROBIOLOGY/22_12.png,groundtruth,22_12.txt,test803Crystal Growth & Design,2024_15,Which of the following options best describe the cover story?,"In crystalline solids, especially in rotaxanes, solvates are common as a result of intrinsic topologies. Our goal is to explore solvent roles in rotaxane crystallization using the supramolecular cluster methodology and tetralactam macrocycle-based rotaxanes. Understanding solvate formation is crucial for applying molecular machines in the solid state.",A,MAC_Bench/ACS/Cover/Crystal Growth & Design/2024_15.png,MAC_Bench/ACS/Cover/Crystal Growth & Design/2024_15.png,groundtruth,2024_15.txt,MAC_Bench/ACS/Cover/Crystal Growth & Design/2023_9.png,MAC_Bench/ACS/Cover/Crystal Growth & Design/2023_9.png,clip,2023_9.txt,MAC_Bench/ACS/Cover/Crystal Growth & Design/2024_16.png,MAC_Bench/ACS/Cover/Crystal Growth & Design/2024_16.png,ave_3,2024_16.txt,MAC_Bench/ACS/Cover/Crystal Growth & Design/2022_8.png,MAC_Bench/ACS/Cover/Crystal Growth & Design/2022_8.png,vith,2022_8.txt,train804Nature Metabolism,6_10,Which of the following options best describe the cover story?,"Bone-to-brain crosstalk805Bone-derived sclerostin accelerates the progression of Alzheimer’s disease (AD) by deregulating the Wnt–β-catenin signalling pathway in the brain. The image is a staining of the enzyme β-secretase (essential for AD pathogenesis) in a hippocampus section from a mouse model of AD.806See Shi et al.807Image: Baosheng Guo, Nanjing University. Cover Design: Thomas Phillips.",C,MAC_Bench/Nature/Cover/Nature Metabolism/3_11.png,MAC_Bench/Nature/Cover/Nature Metabolism/3_11.png,ave_2,3_11.txt,MAC_Bench/Nature/Cover/Nature Metabolism/5_1.png,MAC_Bench/Nature/Cover/Nature Metabolism/5_1.png,clip,5_1.txt,MAC_Bench/Nature/Cover/Nature Metabolism/6_10.png,MAC_Bench/Nature/Cover/Nature Metabolism/6_10.png,groundtruth,6_10.txt,MAC_Bench/Nature/Cover/Nature Metabolism/5_12.png,MAC_Bench/Nature/Cover/Nature Metabolism/5_12.png,vitg,5_12.txt,train808Trends in Endocrinology & Metabolism,35_10,Which of the following options best describe the cover story?,"A tug-of-war between bacteria and immune cells for certain metabolites809gives the winning side the chance to survive. In recent years, it has become apparent810that metabolism is crucial for immune cell function; it is now also clear that pathogens811have adapted to utilise cellular metabolism for their own survival. This month, Almeida812et al. (pp. 235—248) detail how macrophage metabolism can accumulate intermediate813metabolites to interfere with bacterial metabolism. In retaliation, certain bacteria814have815adapted macrophage metabolism to confer fitness advantages. The cover represents816this constant battle between macrophages (in blue) and bacteria (in purple) over817metabolites for survival. Cover credit: concept design from Ayesha Dhillon-LaBrooy818and Luís Almeida; illustration/colourisation from Ying Pung.",C,MAC_Bench/Cell/Cover/Trends in Endocrinology & Metabolism/34_4.png,MAC_Bench/Cell/Cover/Trends in Endocrinology & Metabolism/34_4.png,ave_2,34_4.txt,MAC_Bench/Cell/Cover/Trends in Endocrinology & Metabolism/34_5.png,MAC_Bench/Cell/Cover/Trends in Endocrinology & Metabolism/34_5.png,clip,34_5.txt,MAC_Bench/Cell/Cover/Trends in Endocrinology & Metabolism/35_10.png,MAC_Bench/Cell/Cover/Trends in Endocrinology & Metabolism/35_10.png,groundtruth,35_10.txt,MAC_Bench/Cell/Cover/Trends in Endocrinology & Metabolism/35_5.png,MAC_Bench/Cell/Cover/Trends in Endocrinology & Metabolism/35_5.png,vitg,35_5.txt,train819ACS Infectious Diseases,2024_10,Which of the following options best describe the cover story?,"Bi(III)-based compounds can allosterically target a SARS-CoV-2 nsp14/nsp10 complex to disrupt its MTase and ExoN activity, leading to inhibition of SARS-CoV-2 replication in mammalian cells, which is attributable to the Bi compounds’ ability to displace zinc ions from the zinc-finger sites of the nsp14/nsp10 complex and",C,MAC_Bench/ACS/Cover/ACS Infectious Diseases/2025_1.png,MAC_Bench/ACS/Cover/ACS Infectious Diseases/2025_1.png,clip,2025_1.txt,MAC_Bench/ACS/Cover/ACS Infectious Diseases/2018_6.png,MAC_Bench/ACS/Cover/ACS Infectious Diseases/2018_6.png,vith,2018_6.txt,MAC_Bench/ACS/Cover/ACS Infectious Diseases/2024_10.png,MAC_Bench/ACS/Cover/ACS Infectious Diseases/2024_10.png,groundtruth,2024_10.txt,MAC_Bench/ACS/Cover/ACS Infectious Diseases/2024_6.png,MAC_Bench/ACS/Cover/ACS Infectious Diseases/2024_6.png,vitg,2024_6.txt,train820Trends in Genetics,40_4,Which of the following options best describe the cover story?,"The brain is a genetic ‘mosaic’ comprising a patchwork of cells with821distinct DNA sequences. In this issue, Sahib Sran, Amanda Ringland, and Tracy822Bedrosian describe sources of genomic diversity that contribute to building the mosaic823brain. Expanding beyond the period of neurodevelopment, they consider complex824origins of brain mosaicism that arise throughout the entire lifespan from embryogenesis825through aging. Image credit: erhui1979/Getty Images.",A,MAC_Bench/Cell/Cover/Trends in Genetics/40_4.png,MAC_Bench/Cell/Cover/Trends in Genetics/40_4.png,groundtruth,40_4.txt,MAC_Bench/Cell/Cover/Trends in Genetics/38_8.png,MAC_Bench/Cell/Cover/Trends in Genetics/38_8.png,ave_3,38_8.txt,MAC_Bench/Cell/Cover/Trends in Genetics/39_10.png,MAC_Bench/Cell/Cover/Trends in Genetics/39_10.png,ave_2,39_10.txt,MAC_Bench/Cell/Cover/Trends in Genetics/37_10.png,MAC_Bench/Cell/Cover/Trends in Genetics/37_10.png,clip,37_10.txt,train826Nature Biomedical Engineering,8_4,Which of the following options best describe the cover story?,"Bacteria and neutrophil extracellular traps drive dental calculi827This issue highlights a near-infrared dye for fluorescence-guided tumour resection and the assessment of wound healing, an inexpensive light-sheet fluorescence microscope for the high-resolution imaging of cleared and living samples at scale, transient pacing in pigs with complete heart block via myocardial injection of mRNA coding for a transcription factor, an analysis of neuroimaging data across mental health, neurodegenerative, psychiatric and neurodevelopmental diagnostic categories, that blocking the mechanical sensor PIEZO1 in cytotoxic T lymphocytes augments their cytotoxicity against tumour cells, and that bacteria-mediated resistance of neutrophil extracellular traps to enzymatic degradation drives the formation of dental calculi.828The cover illustrates that the development of dental calculi involves bacteria in local mature biofilms converting the DNA in neutrophil extracellular traps from being degradable by the enzyme DNase I to being degradation-resistant.829See Wan et al.830Image: Mei-chen Wan, The Fourth Military Medical University. Cover design: Alex Wing.",C,MAC_Bench/Nature/Cover/Nature Biomedical Engineering/8_3.png,MAC_Bench/Nature/Cover/Nature Biomedical Engineering/8_3.png,vitg,8_3.txt,MAC_Bench/Nature/Cover/Nature Biomedical Engineering/5_2.png,MAC_Bench/Nature/Cover/Nature Biomedical Engineering/5_2.png,clip,5_2.txt,MAC_Bench/Nature/Cover/Nature Biomedical Engineering/8_4.png,MAC_Bench/Nature/Cover/Nature Biomedical Engineering/8_4.png,groundtruth,8_4.txt,MAC_Bench/Nature/Cover/Nature Biomedical Engineering/7_2.png,MAC_Bench/Nature/Cover/Nature Biomedical Engineering/7_2.png,ave_1,7_2.txt,train831Neuron,113_4,Which of the following options best describe the cover story?,"On the cover: In this special issue of Neuron, we present a collection of reviews and perspectives on the neurobiology of aging.832The causes of brain aging are multidimensional and complex. Highlighting this, the833cover image is provided by Schwartz and colleagues, who discuss the impact of the immune system on brain aging and propose the provocative834idea of anti-aging immune therapy.",D,MAC_Bench/Cell/Cover/Neuron/113_1.png,MAC_Bench/Cell/Cover/Neuron/113_1.png,clip,113_1.txt,MAC_Bench/Cell/Cover/Neuron/109_8.png,MAC_Bench/Cell/Cover/Neuron/109_8.png,ave_2,109_8.txt,MAC_Bench/Cell/Cover/Neuron/106_4.png,MAC_Bench/Cell/Cover/Neuron/106_4.png,ave_3,106_4.txt,MAC_Bench/Cell/Cover/Neuron/113_4.png,MAC_Bench/Cell/Cover/Neuron/113_4.png,groundtruth,113_4.txt,val835Trends in Immunology,46_2,Which of the following options best describe the cover story?,"Experiments with particular specific pathogen-free (SPF)-inbred mouse836strains from different laboratories often yield conflicting data due to microbiota837variations838due to housing conditions. On pages 17–28, Rosshart, Bruno, and Schueler present839the option of using natural microbiota from wild mice to outcompete and replace840conventional laboratory SPF murine gut microbiota via co-housing (wildlings). They841propose that this may yield more robust, reproducible, and generalizable mouse data842in biomedical research than other models. Image credit: Ethan Tyler, NIH Division843of844Medical Arts.",C,MAC_Bench/Cell/Cover/Trends in Immunology/42_9.png,MAC_Bench/Cell/Cover/Trends in Immunology/42_9.png,ave_2,42_9.txt,MAC_Bench/Cell/Cover/Trends in Immunology/43_5.png,MAC_Bench/Cell/Cover/Trends in Immunology/43_5.png,ave_3,43_5.txt,MAC_Bench/Cell/Cover/Trends in Immunology/46_2.png,MAC_Bench/Cell/Cover/Trends in Immunology/46_2.png,groundtruth,46_2.txt,MAC_Bench/Cell/Cover/Trends in Immunology/46_1.png,MAC_Bench/Cell/Cover/Trends in Immunology/46_1.png,clip,46_1.txt,train845Developmental Cell,59_13,Which of the following options best describe the cover story?,"On the cover: Wiring cellular decision-making during trunk development. The image846shows a Trunk-Like Structures (TLS) used in this study in combination with a molecular847recorder to investigate progenitor cell dynamics during mouse gastrulation and early848organogenesis. TLS is depicted as a complex mixture of wires which reflect their underlying849cell types from fluorescent staining on top of a phylogenetic lineage tree with leaves850colored by different cell types, to symbolize the complex repertoire of differentiation851decisions that we characterized to ensure correct tissue morphogenesis. To learn more852about how the authors assess the features of axial elongation and trunk tissue morphogenesis853using TLSs, see Bolondi et al. Image credit: Adriano Bolondi.",D,MAC_Bench/Cell/Cover/Developmental Cell/59_8.png,MAC_Bench/Cell/Cover/Developmental Cell/59_8.png,vitg,59_8.txt,MAC_Bench/Cell/Cover/Developmental Cell/59_21.png,MAC_Bench/Cell/Cover/Developmental Cell/59_21.png,vith,59_21.txt,MAC_Bench/Cell/Cover/Developmental Cell/59_11.png,MAC_Bench/Cell/Cover/Developmental Cell/59_11.png,clip,59_11.txt,MAC_Bench/Cell/Cover/Developmental Cell/59_13.png,MAC_Bench/Cell/Cover/Developmental Cell/59_13.png,groundtruth,59_13.txt,val854Trends in Endocrinology & Metabolism,35_2,Which of the following options best describe the cover story?,"Restoring functional beta cell mass is an essential step in curing855diabetes. While regenerating beta cells directly within the pancreas is an attractive856solution, its clinical translation has proven to be challenging. This month, Bourgeois857and colleagues discuss how new insights into beta cell regeneration can be used to858change diabetes therapy, shifting from “caring for” to “curing” this disorder. The859cover,860symbolizing renewal and transformation, merges a phoenix rising from its ashes with861a pancreatic islet. Cover credit: Len Degroote / Althar.be",D,MAC_Bench/Cell/Cover/Trends in Endocrinology & Metabolism/34_5.png,MAC_Bench/Cell/Cover/Trends in Endocrinology & Metabolism/34_5.png,clip,34_5.txt,MAC_Bench/Cell/Cover/Trends in Endocrinology & Metabolism/34_4.png,MAC_Bench/Cell/Cover/Trends in Endocrinology & Metabolism/34_4.png,ave_2,34_4.txt,MAC_Bench/Cell/Cover/Trends in Endocrinology & Metabolism/35_7.png,MAC_Bench/Cell/Cover/Trends in Endocrinology & Metabolism/35_7.png,vitg,35_7.txt,MAC_Bench/Cell/Cover/Trends in Endocrinology & Metabolism/35_2.png,MAC_Bench/Cell/Cover/Trends in Endocrinology & Metabolism/35_2.png,groundtruth,35_2.txt,val862ACS Applied Optical Materials,2024_5,Which of the following options best describe the cover story?,"The authors develop a nonlinear optical imaging technique, which can rapidly visualize hidden interfacial defects in on-chip integrated microdevices. This technique provides a noninvasive means to boost the yield rate of on-chip integrations when being deployed in the production line for in-situ monitoring.",D,MAC_Bench/ACS/Cover/ACS Applied Optical Materials/2024_8.png,MAC_Bench/ACS/Cover/ACS Applied Optical Materials/2024_8.png,vitg,2024_8.txt,MAC_Bench/ACS/Cover/ACS Applied Optical Materials/2024_10.png,MAC_Bench/ACS/Cover/ACS Applied Optical Materials/2024_10.png,clip,2024_10.txt,MAC_Bench/ACS/Cover/ACS Applied Optical Materials/2024_2.png,MAC_Bench/ACS/Cover/ACS Applied Optical Materials/2024_2.png,vith,2024_2.txt,MAC_Bench/ACS/Cover/ACS Applied Optical Materials/2024_5.png,MAC_Bench/ACS/Cover/ACS Applied Optical Materials/2024_5.png,groundtruth,2024_5.txt,test863NATURE REVIEWS NEUROSCIENCE,25_9,Which of the following options best describe the cover story?,"‘Altered activity’, inspired by the Perspective on p272.864Cover design: Jennie Vallis",D,MAC_Bench/Nature/Cover/NATURE REVIEWS NEUROSCIENCE/25_3.png,MAC_Bench/Nature/Cover/NATURE REVIEWS NEUROSCIENCE/25_3.png,ave_3,25_3.txt,MAC_Bench/Nature/Cover/NATURE REVIEWS NEUROSCIENCE/25_10.png,MAC_Bench/Nature/Cover/NATURE REVIEWS NEUROSCIENCE/25_10.png,clip,25_10.txt,MAC_Bench/Nature/Cover/NATURE REVIEWS NEUROSCIENCE/25_6.png,MAC_Bench/Nature/Cover/NATURE REVIEWS NEUROSCIENCE/25_6.png,vitg,25_6.txt,MAC_Bench/Nature/Cover/NATURE REVIEWS NEUROSCIENCE/25_9.png,MAC_Bench/Nature/Cover/NATURE REVIEWS NEUROSCIENCE/25_9.png,groundtruth,25_9.txt,val865Industrial & Engineering Chemistry Research,2024_33,Which of the following options best describe the cover story?,The cover sketches the challenge of integrating multiple scales into a process model and how this can be performed with compartment models. These compartment models are applied to an industrial rotary dryer shown in the figures and the background.,A,MAC_Bench/ACS/Cover/Industrial & Engineering Chemistry Research/2024_33.png,MAC_Bench/ACS/Cover/Industrial & Engineering Chemistry Research/2024_33.png,groundtruth,2024_33.txt,MAC_Bench/ACS/Cover/Industrial & Engineering Chemistry Research/2023_45.png,MAC_Bench/ACS/Cover/Industrial & Engineering Chemistry Research/2023_45.png,clip,2023_45.txt,MAC_Bench/ACS/Cover/Industrial & Engineering Chemistry Research/2018_1.png,MAC_Bench/ACS/Cover/Industrial & Engineering Chemistry Research/2018_1.png,vith,2018_1.txt,MAC_Bench/ACS/Cover/Industrial & Engineering Chemistry Research/2023_51.png,MAC_Bench/ACS/Cover/Industrial & Engineering Chemistry Research/2023_51.png,vitg,2023_51.txt,train866Trends in Biotechnology,42_1,Which of the following options best describe the cover story?,"CRISPR-driven genetic circuits have offered promising solutions to867burgeoning challenges in RNA sensing. In pages 1601–1614 of this issue, Jiang and868colleagues discuss cutting-edge developments in CRISPR-powered RNA sensors869in vivo, in addition to providing new insights on the future development of these870programmable RNA sensors. Cover image from Baojun Wang.",A,MAC_Bench/Cell/Cover/Trends in Biotechnology/42_1.png,MAC_Bench/Cell/Cover/Trends in Biotechnology/42_1.png,groundtruth,42_1.txt,MAC_Bench/Cell/Cover/Trends in Biotechnology/42_4.png,MAC_Bench/Cell/Cover/Trends in Biotechnology/42_4.png,vith,42_4.txt,MAC_Bench/Cell/Cover/Trends in Biotechnology/41_7.png,MAC_Bench/Cell/Cover/Trends in Biotechnology/41_7.png,clip,41_7.txt,MAC_Bench/Cell/Cover/Trends in Biotechnology/41_5.png,MAC_Bench/Cell/Cover/Trends in Biotechnology/41_5.png,vitg,41_5.txt,train871Biomacromolecules,2024_9,Which of the following options best describe the cover story?,"The combination of experimental techniques and computational simulations presents a powerful approach to study polymer vesicles at multiple scales, which enables us to explore the interplay between phenomena and mechanisms in the emerging field of polymersome-based drug delivery systems.",B,MAC_Bench/ACS/Cover/Biomacromolecules/2023_1.png,MAC_Bench/ACS/Cover/Biomacromolecules/2023_1.png,clip,2023_1.txt,MAC_Bench/ACS/Cover/Biomacromolecules/2024_9.png,MAC_Bench/ACS/Cover/Biomacromolecules/2024_9.png,groundtruth,2024_9.txt,MAC_Bench/ACS/Cover/Biomacromolecules/2021_7.png,MAC_Bench/ACS/Cover/Biomacromolecules/2021_7.png,vitg,2021_7.txt,MAC_Bench/ACS/Cover/Biomacromolecules/2020_1.png,MAC_Bench/ACS/Cover/Biomacromolecules/2020_1.png,ave_3,2020_1.txt,train872ACS Infectious Diseases,2024_8,Which of the following options best describe the cover story?,"An efflux pump inhibitor, IITR08367, disrupts bacterial energetics that lead to reduced fosfomycin efflux and biofilm formation in Acinetobacter baumannii.",A,MAC_Bench/ACS/Cover/ACS Infectious Diseases/2024_8.png,MAC_Bench/ACS/Cover/ACS Infectious Diseases/2024_8.png,groundtruth,2024_8.txt,MAC_Bench/ACS/Cover/ACS Infectious Diseases/2024_5.png,MAC_Bench/ACS/Cover/ACS Infectious Diseases/2024_5.png,ave_2,2024_5.txt,MAC_Bench/ACS/Cover/ACS Infectious Diseases/2025_2.png,MAC_Bench/ACS/Cover/ACS Infectious Diseases/2025_2.png,vitg,2025_2.txt,MAC_Bench/ACS/Cover/ACS Infectious Diseases/2023_9.png,MAC_Bench/ACS/Cover/ACS Infectious Diseases/2023_9.png,clip,2023_9.txt,train873NATURE MEDICINE,30_6,Which of the following options best describe the cover story?,"Focus on Precision Health874This special Focus issue is all about precision health, the tailoring of preventive and treatment approaches to individuals based on their unique characteristics, across different geographical and clinical contexts.875The cover shows a heart created from fruits and vegetables representing the work from Bermingham et al. showing that personalized dietary programs can lead to significant improvements in cardiometabolic and gut health.876See Bermingham et al.877Image: ZOE. Cover design: Marina Spence",B,MAC_Bench/Nature/Cover/NATURE MEDICINE/30_8.png,MAC_Bench/Nature/Cover/NATURE MEDICINE/30_8.png,clip,30_8.txt,MAC_Bench/Nature/Cover/NATURE MEDICINE/30_6.png,MAC_Bench/Nature/Cover/NATURE MEDICINE/30_6.png,groundtruth,30_6.txt,MAC_Bench/Nature/Cover/NATURE MEDICINE/29_8.png,MAC_Bench/Nature/Cover/NATURE MEDICINE/29_8.png,vith,29_8.txt,MAC_Bench/Nature/Cover/NATURE MEDICINE/29_6.png,MAC_Bench/Nature/Cover/NATURE MEDICINE/29_6.png,vitg,29_6.txt,train878The Journal of Physical Chemistry A,2025_5,Which of the following options best describe the cover story?,". The cover art depicts a selection of images that represent important scientific results achieved by Saykally and his group. Top left: image showing second harmonic generation probing of solutes at an air-water interface (reprinted with permission from J. Phys. Chem. Lett. 2018, 9, (16), 4753–4757, DOI:",B,MAC_Bench/ACS/Cover/The Journal of Physical Chemistry A/2024_50.png,MAC_Bench/ACS/Cover/The Journal of Physical Chemistry A/2024_50.png,clip,2024_50.txt,MAC_Bench/ACS/Cover/The Journal of Physical Chemistry A/2025_5.png,MAC_Bench/ACS/Cover/The Journal of Physical Chemistry A/2025_5.png,groundtruth,2025_5.txt,MAC_Bench/ACS/Cover/The Journal of Physical Chemistry A/2021_6.png,MAC_Bench/ACS/Cover/The Journal of Physical Chemistry A/2021_6.png,vith,2021_6.txt,MAC_Bench/ACS/Cover/The Journal of Physical Chemistry A/2024_41.png,MAC_Bench/ACS/Cover/The Journal of Physical Chemistry A/2024_41.png,vitg,2024_41.txt,train879Science Robotics,10_98,Which of the following options best describe the cover story?,"ONLINE COVER Exoskeletons—Overcoming the Ceiling Effect in Motor Skills. Learning a motor skill often plateaus, resulting in the ceiling effect whereby no further training can improve the skill level. Furuya et al. have developed a hand exoskeleton for pianists to surmount the ceiling effect in their skill level through exposure to complex finger movements that would not be possible voluntarily. They demonstrated that, after the exoskeleton was no longer used, the pianists could play faster with both their trained hand and their contralateral untrained hand with evidence of neuroplastic adaptation. This month’s cover is an image of a pianist training with the exoskeleton. Credit: Y. Ogasawara",C,MAC_Bench/Science/Cover/Science Robotics/7_67.png,MAC_Bench/Science/Cover/Science Robotics/7_67.png,ave_2,7_67.txt,MAC_Bench/Science/Cover/Science Robotics/3_25.png,MAC_Bench/Science/Cover/Science Robotics/3_25.png,clip,3_25.txt,MAC_Bench/Science/Cover/Science Robotics/10_98.png,MAC_Bench/Science/Cover/Science Robotics/10_98.png,groundtruth,10_98.txt,MAC_Bench/Science/Cover/Science Robotics/10_99.png,MAC_Bench/Science/Cover/Science Robotics/10_99.png,ave_3,10_99.txt,train880Med,5_3,Which of the following options best describe the cover story?,"On the cover: Gastric cancer ranks as the fifth most prevalent cancer globally and881the fourth leading cause of cancer-related mortality. The prognosis for advanced gastric882cancer is poor, underscoring the urgent need for more effective treatment strategies.883In this issue of Med, Li et al. conducted a phase 2 clinical study to explore the efficacy and safety of combining884two different anti-HER2 antibodies plus XELOX as first-line therapy for patients with885HER2-positive advanced gastric cancer. The study reveals that the treatment regimen886significantly extended progression-free survival and improved antitumor response in887these patients, with manageable safety profiles, supporting the clinical benefits888of dual HER2 blockade.",C,MAC_Bench/Cell/Cover/Med/4_6.png,MAC_Bench/Cell/Cover/Med/4_6.png,vith,4_6.txt,MAC_Bench/Cell/Cover/Med/2_4.png,MAC_Bench/Cell/Cover/Med/2_4.png,clip,2_4.txt,MAC_Bench/Cell/Cover/Med/5_3.png,MAC_Bench/Cell/Cover/Med/5_3.png,groundtruth,5_3.txt,MAC_Bench/Cell/Cover/Med/3_10.png,MAC_Bench/Cell/Cover/Med/3_10.png,vitg,3_10.txt,train889Trends in Cancer,10_8,Which of the following options best describe the cover story?,"Ferroptotic therapy represents a promising approach in cancer treatment890by exploiting nonapoptotic cell death, characterized by iron accumulation and891uncontrolled lipid peroxidation, to target cancer cells. However, its use has potential892adverse effects as well as context-dependent effects on anticancer immunity that893require consideration for successful implementation. In this issue, Catanzaro et al.894propose that immunogenicity of ferroptosis is context-dependent. In another review,895Liu et al. discuss the adverse events related to targeted ferroptosis-based therapy. The896cover depicts a golfer using his nine-iron to hit the ball (inducing ferroptosis).897Depending898on the conditions (TME, immune cells, etc.), the ball can go into the hole (on target899effect, killing cancer cell) or land outside the fairway (off-target effect, adverse900events or901immunogenicity). Cover image from gettyimages/chuwy.",B,MAC_Bench/Cell/Cover/Trends in Cancer/10_9.png,MAC_Bench/Cell/Cover/Trends in Cancer/10_9.png,clip,10_9.txt,MAC_Bench/Cell/Cover/Trends in Cancer/10_8.png,MAC_Bench/Cell/Cover/Trends in Cancer/10_8.png,groundtruth,10_8.txt,MAC_Bench/Cell/Cover/Trends in Cancer/8_5.png,MAC_Bench/Cell/Cover/Trends in Cancer/8_5.png,ave_2,8_5.txt,MAC_Bench/Cell/Cover/Trends in Cancer/9_4.png,MAC_Bench/Cell/Cover/Trends in Cancer/9_4.png,vitg,9_4.txt,train902Trends in Biotechnology,42_7,Which of the following options best describe the cover story?,"Interactions between algae and the phycosome may impact the productivity903of industrial cultures. This fluorescence microscopy image of an aggregate of Chlorella sp.904SLA-04 and its phycosome underlines the ecological complexity of xenic algal cultures.905In906pages 680-698 of this issue, Miller and colleagues highlight the current understanding907of908the phycosome and some future directions for taking advantage of phycosome ecology909in910production systems. Cover image taken by Isaac Miller at the Center for Biofilm Engineering911in the Imaging Core Facility.",D,MAC_Bench/Cell/Cover/Trends in Biotechnology/42_1.png,MAC_Bench/Cell/Cover/Trends in Biotechnology/42_1.png,vitg,42_1.txt,MAC_Bench/Cell/Cover/Trends in Biotechnology/39_6.png,MAC_Bench/Cell/Cover/Trends in Biotechnology/39_6.png,clip,39_6.txt,MAC_Bench/Cell/Cover/Trends in Biotechnology/32_1.png,MAC_Bench/Cell/Cover/Trends in Biotechnology/32_1.png,vith,32_1.txt,MAC_Bench/Cell/Cover/Trends in Biotechnology/42_7.png,MAC_Bench/Cell/Cover/Trends in Biotechnology/42_7.png,groundtruth,42_7.txt,train912Science Translational Medicine,17_783,Which of the following options best describe the cover story?,"ONLINE COVER Manipulating Mitochondrial DNA. The cover shows a cross-section of a skeletal muscle fiber stained for cytochrome c oxidase activity (dark brown), an indicator of mitochondrial function, in a mouse treated with a mitochondrial DNA (mtDNA) base editor to correct a mutation in a mitochondrial tRNA. Mitochondrial disorders are often caused by mutations in mtDNA that are difficult to correct with traditional gene editing. Barrera-Paez et al. used a dose-dependent mitochondrial DddA-derived cytosine base editor (DdCBE) to successfully correct a mitochondrial tRNA mutation in mouse heart and muscle. However, at the highest doses of editing, DdCBE induced off-target DNA edits resulting in severe adverse effects in the mice. Together, the results suggest that DdCBE is a promising tool for mitochondrial gene editing, but caution is required to avoid dose-dependent adverse effects. Credit: Jose Domingo Barrera-Paez",B,MAC_Bench/Science/Cover/Science Translational Medicine/15_724.png,MAC_Bench/Science/Cover/Science Translational Medicine/15_724.png,clip,15_724.txt,MAC_Bench/Science/Cover/Science Translational Medicine/17_783.png,MAC_Bench/Science/Cover/Science Translational Medicine/17_783.png,groundtruth,17_783.txt,MAC_Bench/Science/Cover/Science Translational Medicine/16_730.png,MAC_Bench/Science/Cover/Science Translational Medicine/16_730.png,vith,16_730.txt,MAC_Bench/Science/Cover/Science Translational Medicine/15_703.png,MAC_Bench/Science/Cover/Science Translational Medicine/15_703.png,vitg,15_703.txt,train913ACS Photonics,2024_12,Which of the following options best describe the cover story?,"A pump pulse is used to drive lattice vibration, and a probe pulse accompanied by a reference pulse is used to probe the vibration.",D,MAC_Bench/ACS/Cover/ACS Photonics/2019_10.png,MAC_Bench/ACS/Cover/ACS Photonics/2019_10.png,vitg,2019_10.txt,MAC_Bench/ACS/Cover/ACS Photonics/2016_12.png,MAC_Bench/ACS/Cover/ACS Photonics/2016_12.png,clip,2016_12.txt,MAC_Bench/ACS/Cover/ACS Photonics/2017_9.png,MAC_Bench/ACS/Cover/ACS Photonics/2017_9.png,vith,2017_9.txt,MAC_Bench/ACS/Cover/ACS Photonics/2024_12.png,MAC_Bench/ACS/Cover/ACS Photonics/2024_12.png,groundtruth,2024_12.txt,train914Crystal Growth & Design,2024_11,Which of the following options best describe the cover story?,"The convolution of spatial confinement and interparticle interactions controls the formation of superparticles differing in structure and function, resulting in emergent properties. In this review, Marino et al. discuss recent developments in this topical area spanning length scales of colloidal particle assembly from nano- to micrometers. The cover image was AI-generated using Microsoft Copilot.",A,MAC_Bench/ACS/Cover/Crystal Growth & Design/2024_11.png,MAC_Bench/ACS/Cover/Crystal Growth & Design/2024_11.png,groundtruth,2024_11.txt,MAC_Bench/ACS/Cover/Crystal Growth & Design/2017_2.png,MAC_Bench/ACS/Cover/Crystal Growth & Design/2017_2.png,vitg,2017_2.txt,MAC_Bench/ACS/Cover/Crystal Growth & Design/2024_10.png,MAC_Bench/ACS/Cover/Crystal Growth & Design/2024_10.png,vith,2024_10.txt,MAC_Bench/ACS/Cover/Crystal Growth & Design/2024_13.png,MAC_Bench/ACS/Cover/Crystal Growth & Design/2024_13.png,clip,2024_13.txt,test915Biomacromolecules,2024_10,Which of the following options best describe the cover story?,"The hierarchical evolution of the development of one-component multifunctional sequence-defined ionizable amphiphilic Janus dendrimers (IAJDs) co-assembling with mRNA into dendrimersome nanoparticles (DNPs) targeting in vivo delivery to various organs is illustrated. This process started with the discovery of the self-assembly of helical rodlike and spherical helices virus-like supramolecular assemblies self-organizing periodic and quasiperiodic arrays including Frank–Kasper and quasicrystals and biological membrane mimics, and continued with elucidation of mechanisms, to unravel a one-component viral-like programmed synthetic vector for nanomedicine.",B,MAC_Bench/ACS/Cover/Biomacromolecules/2020_5.png,MAC_Bench/ACS/Cover/Biomacromolecules/2020_5.png,ave_2,2020_5.txt,MAC_Bench/ACS/Cover/Biomacromolecules/2024_10.png,MAC_Bench/ACS/Cover/Biomacromolecules/2024_10.png,groundtruth,2024_10.txt,MAC_Bench/ACS/Cover/Biomacromolecules/2022_5.png,MAC_Bench/ACS/Cover/Biomacromolecules/2022_5.png,vith,2022_5.txt,MAC_Bench/ACS/Cover/Biomacromolecules/2024_7.png,MAC_Bench/ACS/Cover/Biomacromolecules/2024_7.png,clip,2024_7.txt,train916Biophysical Reports,4_4,Which of the following options best describe the cover story?,"On the cover: SpinFlux uses a spinning disk with pinholes in its illumination and917emission paths to sequentially illuminate regions in the sample during each measurement.918The resulting intensity-modulated emission signal is analyzed for each individual919pattern to localize emitters with up to 3.5-fold improved precision. The precision920improvement of SpinFlux is derived from retrieving the position of an emitter relative921to individual illumination patterns, which adds to existing point spread function922information from single-molecule localization microscopy. Kalisvaart et al. DOI: https://doi.org/10.1016/j.bpr.2024.100143",B,MAC_Bench/Cell/Cover/Biophysical Reports/1_1.png,MAC_Bench/Cell/Cover/Biophysical Reports/1_1.png,ave_2,1_1.txt,MAC_Bench/Cell/Cover/Biophysical Reports/4_4.png,MAC_Bench/Cell/Cover/Biophysical Reports/4_4.png,groundtruth,4_4.txt,MAC_Bench/Cell/Cover/Biophysical Reports/2_3.png,MAC_Bench/Cell/Cover/Biophysical Reports/2_3.png,ave_3,2_3.txt,MAC_Bench/Cell/Cover/Biophysical Reports/4_3.png,MAC_Bench/Cell/Cover/Biophysical Reports/4_3.png,clip,4_3.txt,train923Nature Neuroscience,27_12,Which of the following options best describe the cover story?,"AgRP neurons encode circadian mealtimes924To maximize fitness, most animals adopt an optimal foraging strategy to procure the highest energy at the lowest cost. For example, nighttime is likely to be preferred by nocturnal animals owing to its relative safety from predators and the ease of food availability. In an environment with such periodic food availability, AgRP neurons are entrained by past successful feeding experiences and use this circadian information to promote foraging at similar time windows on subsequent days to maximize the chance of feeding.925See Sayar-Atasoy et al.926Image: Muhammed Ikbal Alp, InSpira. Cover Design: Marina Corral Spence",D,MAC_Bench/Nature/Cover/Nature Neuroscience/24_6.png,MAC_Bench/Nature/Cover/Nature Neuroscience/24_6.png,clip,24_6.txt,MAC_Bench/Nature/Cover/Nature Neuroscience/25_10.png,MAC_Bench/Nature/Cover/Nature Neuroscience/25_10.png,ave_3,25_10.txt,MAC_Bench/Nature/Cover/Nature Neuroscience/28_1.png,MAC_Bench/Nature/Cover/Nature Neuroscience/28_1.png,vith,28_1.txt,MAC_Bench/Nature/Cover/Nature Neuroscience/27_12.png,MAC_Bench/Nature/Cover/Nature Neuroscience/27_12.png,groundtruth,27_12.txt,train927CELL RESEARCH,34_8,Which of the following options best describe the cover story?,"The image illustrates a Chinese historical story, depicting Taigong Jiang fishing with his hook, reminiscent of the innovative proximity labeling tool, PhastID. PhastID identifies ATP6AP1, an unconventional GEF of Rheb. The C-tail at the end of ATP6AP1 can be used as a switch for Rheb to regulate the activation of mTORC1 signaling. Just as the two different states of the fish in the image, activating Rheb or not has distinct impacts on cellular functions. See page 355–369 by Ran Feng et al. for details.",A,MAC_Bench/Nature/Cover/CELL RESEARCH/34_8.png,MAC_Bench/Nature/Cover/CELL RESEARCH/34_8.png,groundtruth,34_8.txt,MAC_Bench/Nature/Cover/CELL RESEARCH/34_4.png,MAC_Bench/Nature/Cover/CELL RESEARCH/34_4.png,vitg,34_4.txt,MAC_Bench/Nature/Cover/CELL RESEARCH/31_1.png,MAC_Bench/Nature/Cover/CELL RESEARCH/31_1.png,vith,31_1.txt,MAC_Bench/Nature/Cover/CELL RESEARCH/32_10.png,MAC_Bench/Nature/Cover/CELL RESEARCH/32_10.png,clip,32_10.txt,train928ACS Earth and Space Chemistry,2024_10,Which of the following options best describe the cover story?,This backscattered electron image shows the replacement of CuO of Cu2O via a coupled dissolution and precipitation mechanism. The three embedded images depict the reaction scheme of cuprite dissolution in acetate solution: (a) cuprite dissolution reaction; (b) Cu(I) disproportionation to Cu(II) and native Cu; and (c) tenorite precipitation and acetate decarboxylation reaction.,B,MAC_Bench/ACS/Cover/ACS Earth and Space Chemistry/2023_8.png,MAC_Bench/ACS/Cover/ACS Earth and Space Chemistry/2023_8.png,ave_2,2023_8.txt,MAC_Bench/ACS/Cover/ACS Earth and Space Chemistry/2024_10.png,MAC_Bench/ACS/Cover/ACS Earth and Space Chemistry/2024_10.png,groundtruth,2024_10.txt,MAC_Bench/ACS/Cover/ACS Earth and Space Chemistry/2024_11.png,MAC_Bench/ACS/Cover/ACS Earth and Space Chemistry/2024_11.png,clip,2024_11.txt,MAC_Bench/ACS/Cover/ACS Earth and Space Chemistry/2022_1.png,MAC_Bench/ACS/Cover/ACS Earth and Space Chemistry/2022_1.png,ave_3,2022_1.txt,train929Nature Catalysis,7_2,Which of the following options best describe the cover story?,"Radical strain-release930The authors report the use of azabicyclic scaffolds that release their ring strain thanks to an organic photosensitizer activated by visible light. The consequent radical ring opening enables the incorporation of organic fragments, allowing access to functionalized azetidines.931See Rodríguez et al.932Image: Benjamin Large. Cover design: Alex Whitworth.",D,MAC_Bench/Nature/Cover/Nature Catalysis/5_8.png,MAC_Bench/Nature/Cover/Nature Catalysis/5_8.png,vith,5_8.txt,MAC_Bench/Nature/Cover/Nature Catalysis/4_5.png,MAC_Bench/Nature/Cover/Nature Catalysis/4_5.png,vitg,4_5.txt,MAC_Bench/Nature/Cover/Nature Catalysis/6_7.png,MAC_Bench/Nature/Cover/Nature Catalysis/6_7.png,clip,6_7.txt,MAC_Bench/Nature/Cover/Nature Catalysis/7_2.png,MAC_Bench/Nature/Cover/Nature Catalysis/7_2.png,groundtruth,7_2.txt,train933Industrial & Engineering Chemistry Research,2024_1,Which of the following options best describe the cover story?,"The cover depicts an integrated methane dehydroaromatization modular process being transported to natural gas extraction sites across various geographical terrains, ranging from the Rocky Mountains to deserts. The network nodes on the left symbolize the use of computational tools to infer the optimality of the modular process.",B,MAC_Bench/ACS/Cover/Industrial & Engineering Chemistry Research/2021_38.png,MAC_Bench/ACS/Cover/Industrial & Engineering Chemistry Research/2021_38.png,clip,2021_38.txt,MAC_Bench/ACS/Cover/Industrial & Engineering Chemistry Research/2024_1.png,MAC_Bench/ACS/Cover/Industrial & Engineering Chemistry Research/2024_1.png,groundtruth,2024_1.txt,MAC_Bench/ACS/Cover/Industrial & Engineering Chemistry Research/2022_49.png,MAC_Bench/ACS/Cover/Industrial & Engineering Chemistry Research/2022_49.png,vith,2022_49.txt,MAC_Bench/ACS/Cover/Industrial & Engineering Chemistry Research/2018_28.png,MAC_Bench/ACS/Cover/Industrial & Engineering Chemistry Research/2018_28.png,vitg,2018_28.txt,train934NATURE REVIEWS IMMUNOLOGY,24_10,Which of the following options best describe the cover story?,"Membrane organisers, inspired by the Review on p193.935Cover design: Simon Bradbrook",D,MAC_Bench/Nature/Cover/NATURE REVIEWS IMMUNOLOGY/24_7.png,MAC_Bench/Nature/Cover/NATURE REVIEWS IMMUNOLOGY/24_7.png,vitg,24_7.txt,MAC_Bench/Nature/Cover/NATURE REVIEWS IMMUNOLOGY/23_9.png,MAC_Bench/Nature/Cover/NATURE REVIEWS IMMUNOLOGY/23_9.png,ave_3,23_9.txt,MAC_Bench/Nature/Cover/NATURE REVIEWS IMMUNOLOGY/23_11.png,MAC_Bench/Nature/Cover/NATURE REVIEWS IMMUNOLOGY/23_11.png,clip,23_11.txt,MAC_Bench/Nature/Cover/NATURE REVIEWS IMMUNOLOGY/24_10.png,MAC_Bench/Nature/Cover/NATURE REVIEWS IMMUNOLOGY/24_10.png,groundtruth,24_10.txt,train936NATURE REVIEWS CANCER,24_6,Which of the following options best describe the cover story?,"Thriving in an inhospitable environment, inspired by the Review on p448.937Cover design: Lara Crow",A,MAC_Bench/Nature/Cover/NATURE REVIEWS CANCER/24_6.png,MAC_Bench/Nature/Cover/NATURE REVIEWS CANCER/24_6.png,groundtruth,24_6.txt,MAC_Bench/Nature/Cover/NATURE REVIEWS CANCER/24_12.png,MAC_Bench/Nature/Cover/NATURE REVIEWS CANCER/24_12.png,clip,24_12.txt,MAC_Bench/Nature/Cover/NATURE REVIEWS CANCER/24_8.png,MAC_Bench/Nature/Cover/NATURE REVIEWS CANCER/24_8.png,vith,24_8.txt,MAC_Bench/Nature/Cover/NATURE REVIEWS CANCER/24_5.png,MAC_Bench/Nature/Cover/NATURE REVIEWS CANCER/24_5.png,vitg,24_5.txt,train938NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY,21_11,Which of the following options best describe the cover story?,"Looking back on 2023, inspired by the Year in Reviews starting on p72.939Cover design: Laura Marshall.",A,MAC_Bench/Nature/Cover/NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY/21_11.png,MAC_Bench/Nature/Cover/NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY/21_11.png,groundtruth,21_11.txt,MAC_Bench/Nature/Cover/NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY/21_1.png,MAC_Bench/Nature/Cover/NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY/21_1.png,vitg,21_1.txt,MAC_Bench/Nature/Cover/NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY/21_10.png,MAC_Bench/Nature/Cover/NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY/21_10.png,ave_2,21_10.txt,MAC_Bench/Nature/Cover/NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY/20_11.png,MAC_Bench/Nature/Cover/NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY/20_11.png,clip,20_11.txt,test940NATURE IMMUNOLOGY,25_11,Which of the following options best describe the cover story?,"Immune dysregulation in long COVID941Yin et al. use Olink proteomics and single‐cell RNA sequencing (scRNA-seq) analyses to show a dysregulated crosstalk between the cellular and humoral immune responses in individuals with long COVID 8 months after infection with SARS-CoV-2.942See Kailin Yin et al.943Image credit: Amie Fernandez. Cover design: Amie Fernandez",D,MAC_Bench/Nature/Cover/NATURE IMMUNOLOGY/24_4.png,MAC_Bench/Nature/Cover/NATURE IMMUNOLOGY/24_4.png,clip,24_4.txt,MAC_Bench/Nature/Cover/NATURE IMMUNOLOGY/22_7.png,MAC_Bench/Nature/Cover/NATURE IMMUNOLOGY/22_7.png,vith,22_7.txt,MAC_Bench/Nature/Cover/NATURE IMMUNOLOGY/24_9.png,MAC_Bench/Nature/Cover/NATURE IMMUNOLOGY/24_9.png,vitg,24_9.txt,MAC_Bench/Nature/Cover/NATURE IMMUNOLOGY/25_11.png,MAC_Bench/Nature/Cover/NATURE IMMUNOLOGY/25_11.png,groundtruth,25_11.txt,train944Journal of Agricultural and Food Chemistry,2025_6,Which of the following options best describe the cover story?,Starch–lipid complexes (type 5 RS) can effectively alleviate experimentally induced colitis in mice by modulating gut microbiota,B,MAC_Bench/ACS/Cover/Journal of Agricultural and Food Chemistry/2022_1.png,MAC_Bench/ACS/Cover/Journal of Agricultural and Food Chemistry/2022_1.png,ave_1,2022_1.txt,MAC_Bench/ACS/Cover/Journal of Agricultural and Food Chemistry/2025_6.png,MAC_Bench/ACS/Cover/Journal of Agricultural and Food Chemistry/2025_6.png,groundtruth,2025_6.txt,MAC_Bench/ACS/Cover/Journal of Agricultural and Food Chemistry/2022_14.png,MAC_Bench/ACS/Cover/Journal of Agricultural and Food Chemistry/2022_14.png,vitg,2022_14.txt,MAC_Bench/ACS/Cover/Journal of Agricultural and Food Chemistry/2022_43.png,MAC_Bench/ACS/Cover/Journal of Agricultural and Food Chemistry/2022_43.png,clip,2022_43.txt,train945NATURE REVIEWS NEUROSCIENCE,25_3,Which of the following options best describe the cover story?,"‘Synaptic labels’, inspired by the Review on p668.946Cover design: Jennie Vallis",B,MAC_Bench/Nature/Cover/NATURE REVIEWS NEUROSCIENCE/25_5.png,MAC_Bench/Nature/Cover/NATURE REVIEWS NEUROSCIENCE/25_5.png,vitg,25_5.txt,MAC_Bench/Nature/Cover/NATURE REVIEWS NEUROSCIENCE/25_3.png,MAC_Bench/Nature/Cover/NATURE REVIEWS NEUROSCIENCE/25_3.png,groundtruth,25_3.txt,MAC_Bench/Nature/Cover/NATURE REVIEWS NEUROSCIENCE/25_4.png,MAC_Bench/Nature/Cover/NATURE REVIEWS NEUROSCIENCE/25_4.png,ave_2,25_4.txt,MAC_Bench/Nature/Cover/NATURE REVIEWS NEUROSCIENCE/24_4.png,MAC_Bench/Nature/Cover/NATURE REVIEWS NEUROSCIENCE/24_4.png,clip,24_4.txt,train947Nature Reviews Rheumatology,20_4,Which of the following options best describe the cover story?,"Inspired by the Review on p531.948Cover design: Steven Hall",B,MAC_Bench/Nature/Cover/Nature Reviews Rheumatology/19_8.png,MAC_Bench/Nature/Cover/Nature Reviews Rheumatology/19_8.png,ave_3,19_8.txt,MAC_Bench/Nature/Cover/Nature Reviews Rheumatology/20_4.png,MAC_Bench/Nature/Cover/Nature Reviews Rheumatology/20_4.png,groundtruth,20_4.txt,MAC_Bench/Nature/Cover/Nature Reviews Rheumatology/19_2.png,MAC_Bench/Nature/Cover/Nature Reviews Rheumatology/19_2.png,vith,19_2.txt,MAC_Bench/Nature/Cover/Nature Reviews Rheumatology/20_5.png,MAC_Bench/Nature/Cover/Nature Reviews Rheumatology/20_5.png,clip,20_5.txt,train949Nature Microbiology,9_12,Which of the following options best describe the cover story?,"Fungal vesicles activate host immunity950This image shows confocal microscopy of macrophages with the DNA-sensing enzyme cGAS (GFP) translocating from the nucleus to the cytosol in response to the phagocytosis of extracellular vesicles isolated from the fungal pathogen Candida albicans.951See Harding et al.952Credit: Hannah Brown Harding, Massachusetts General Hospital/Harvard Medical School. Cover design: Valentina Monaco.",C,MAC_Bench/Nature/Cover/Nature Microbiology/9_9.png,MAC_Bench/Nature/Cover/Nature Microbiology/9_9.png,vith,9_9.txt,MAC_Bench/Nature/Cover/Nature Microbiology/10_1.png,MAC_Bench/Nature/Cover/Nature Microbiology/10_1.png,vitg,10_1.txt,MAC_Bench/Nature/Cover/Nature Microbiology/9_12.png,MAC_Bench/Nature/Cover/Nature Microbiology/9_12.png,groundtruth,9_12.txt,MAC_Bench/Nature/Cover/Nature Microbiology/7_8.png,MAC_Bench/Nature/Cover/Nature Microbiology/7_8.png,clip,7_8.txt,val953Cell Metabolism,37_1,Which of the following options best describe the cover story?,"On the cover: In this issue, Li et al. develop a high-performance biosensor for arginine, named STAR, which lights up arginine's954functional diversity in physiology and pathology. The cover image is an original artwork955depicting a night sky, resembling the unexplored mystery of arginine metabolism. The956bright stars, arranged in the pattern of the arginine molecular formula, light up957the night sky, which stands for the excellent ability of the STAR sensor in illuminating958arginine metabolism. Artwork by Qing Zhang and Yaqiong Chen.",C,MAC_Bench/Cell/Cover/Cell Metabolism/35_10.png,MAC_Bench/Cell/Cover/Cell Metabolism/35_10.png,ave_3,35_10.txt,MAC_Bench/Cell/Cover/Cell Metabolism/37_2.png,MAC_Bench/Cell/Cover/Cell Metabolism/37_2.png,clip,37_2.txt,MAC_Bench/Cell/Cover/Cell Metabolism/37_1.png,MAC_Bench/Cell/Cover/Cell Metabolism/37_1.png,groundtruth,37_1.txt,MAC_Bench/Cell/Cover/Cell Metabolism/36_3.png,MAC_Bench/Cell/Cover/Cell Metabolism/36_3.png,ave_2,36_3.txt,train959Journal of Chemical Information and Modeling,2025_4,Which of the following options best describe the cover story?,"Extracting relevant structures from free energy molecular simulations can be a daunting task. The newly developed FESTA script simplifies this process, offering ease, robustness, and broad compatibility, making ""fishing"" in the free energy pond both efficient and enjoyable.",D,MAC_Bench/ACS/Cover/Journal of Chemical Information and Modeling/2023_22.png,MAC_Bench/ACS/Cover/Journal of Chemical Information and Modeling/2023_22.png,ave_3,2023_22.txt,MAC_Bench/ACS/Cover/Journal of Chemical Information and Modeling/2025_5.png,MAC_Bench/ACS/Cover/Journal of Chemical Information and Modeling/2025_5.png,clip,2025_5.txt,MAC_Bench/ACS/Cover/Journal of Chemical Information and Modeling/2025_3.png,MAC_Bench/ACS/Cover/Journal of Chemical Information and Modeling/2025_3.png,ave_2,2025_3.txt,MAC_Bench/ACS/Cover/Journal of Chemical Information and Modeling/2025_4.png,MAC_Bench/ACS/Cover/Journal of Chemical Information and Modeling/2025_4.png,groundtruth,2025_4.txt,test960Nature Climate Change,14_8,Which of the following options best describe the cover story?,"Focusing on human health961The human cost of climate change is already visible as adverse impacts on diverse aspects of human health. In this issue, and in an online focus, we include primary research, as well as interview, feature and opinion pieces, that highlight the effects of climate change on human morbidity and mortality, and urge for rapid action.962See Editorial and Online collection963Image and cover design: Alex Whitworth",C,MAC_Bench/Nature/Cover/Nature Climate Change/14_2.png,MAC_Bench/Nature/Cover/Nature Climate Change/14_2.png,clip,14_2.txt,MAC_Bench/Nature/Cover/Nature Climate Change/14_9.png,MAC_Bench/Nature/Cover/Nature Climate Change/14_9.png,ave_1,14_9.txt,MAC_Bench/Nature/Cover/Nature Climate Change/14_8.png,MAC_Bench/Nature/Cover/Nature Climate Change/14_8.png,groundtruth,14_8.txt,MAC_Bench/Nature/Cover/Nature Climate Change/12_1.png,MAC_Bench/Nature/Cover/Nature Climate Change/12_1.png,vitg,12_1.txt,train964ACS Infectious Diseases,2024_12,Which of the following options best describe the cover story?,"This front cover depicts original artwork created by Tatiana Román Valenzuela and is part of the ACS-wide DEIR Cover Art program. The piece illustrates the contributions of Alice Ball, an African American chemist who developed one of the first effective treatments for Hansen’s disease, or more widely known as leprosy. Read more about what inspired Tatiana to create this artwork in the accompanying Editorial. View the article.",D,MAC_Bench/ACS/Cover/ACS Infectious Diseases/2019_3.png,MAC_Bench/ACS/Cover/ACS Infectious Diseases/2019_3.png,vitg,2019_3.txt,MAC_Bench/ACS/Cover/ACS Infectious Diseases/2021_12.png,MAC_Bench/ACS/Cover/ACS Infectious Diseases/2021_12.png,clip,2021_12.txt,MAC_Bench/ACS/Cover/ACS Infectious Diseases/2019_12.png,MAC_Bench/ACS/Cover/ACS Infectious Diseases/2019_12.png,vith,2019_12.txt,MAC_Bench/ACS/Cover/ACS Infectious Diseases/2024_12.png,MAC_Bench/ACS/Cover/ACS Infectious Diseases/2024_12.png,groundtruth,2024_12.txt,train965ACS Chemical Neuroscience,2024_6,Which of the following options best describe the cover story?,"A silver-metallized gold nanorods multicolorimetric sensor array, designed to detect and discriminate dopaminergic agents for assessing nervous system disorders, yielded significant results in simultaneous detection and discrimination of benserazide (Benz), levodopa (",C,MAC_Bench/ACS/Cover/ACS Chemical Neuroscience/2024_13.png,MAC_Bench/ACS/Cover/ACS Chemical Neuroscience/2024_13.png,clip,2024_13.txt,MAC_Bench/ACS/Cover/ACS Chemical Neuroscience/2018_8.png,MAC_Bench/ACS/Cover/ACS Chemical Neuroscience/2018_8.png,vith,2018_8.txt,MAC_Bench/ACS/Cover/ACS Chemical Neuroscience/2024_6.png,MAC_Bench/ACS/Cover/ACS Chemical Neuroscience/2024_6.png,groundtruth,2024_6.txt,MAC_Bench/ACS/Cover/ACS Chemical Neuroscience/2024_11.png,MAC_Bench/ACS/Cover/ACS Chemical Neuroscience/2024_11.png,vitg,2024_11.txt,val966ACS Applied Energy Materials,2025_5,Which of the following options best describe the cover story?,"The image depicts a lanthanum hydride cluster nanoconfined within the porous structure of functionalized carbon hosts, highlighting local interactions between the hydride cluster and the carbon material. View the article.",B,MAC_Bench/ACS/Cover/ACS Applied Energy Materials/2024_8.png,MAC_Bench/ACS/Cover/ACS Applied Energy Materials/2024_8.png,vith,2024_8.txt,MAC_Bench/ACS/Cover/ACS Applied Energy Materials/2025_5.png,MAC_Bench/ACS/Cover/ACS Applied Energy Materials/2025_5.png,groundtruth,2025_5.txt,MAC_Bench/ACS/Cover/ACS Applied Energy Materials/2024_10.png,MAC_Bench/ACS/Cover/ACS Applied Energy Materials/2024_10.png,vitg,2024_10.txt,MAC_Bench/ACS/Cover/ACS Applied Energy Materials/2021_1.png,MAC_Bench/ACS/Cover/ACS Applied Energy Materials/2021_1.png,clip,2021_1.txt,train967The Journal of Physical Chemistry Letters,2025_6,Which of the following options best describe the cover story?,"The illustration shows the ion and charge migration in a perovskite solar cell under reverse electrical bias highlighting the interplay of different species in different layers and interfaces. Using spatially resolved scanning transmission X-ray microscopy and electrochemical impedance spectroscopy, the mechanisms behind these migrations are explored,",D,MAC_Bench/ACS/Cover/The Journal of Physical Chemistry Letters/2022_39.png,MAC_Bench/ACS/Cover/The Journal of Physical Chemistry Letters/2022_39.png,vith,2022_39.txt,MAC_Bench/ACS/Cover/The Journal of Physical Chemistry Letters/2023_27.png,MAC_Bench/ACS/Cover/The Journal of Physical Chemistry Letters/2023_27.png,vitg,2023_27.txt,MAC_Bench/ACS/Cover/The Journal of Physical Chemistry Letters/2023_37.png,MAC_Bench/ACS/Cover/The Journal of Physical Chemistry Letters/2023_37.png,clip,2023_37.txt,MAC_Bench/ACS/Cover/The Journal of Physical Chemistry Letters/2025_6.png,MAC_Bench/ACS/Cover/The Journal of Physical Chemistry Letters/2025_6.png,groundtruth,2025_6.txt,train968Nature Biomedical Engineering,8_1,Which of the following options best describe the cover story?,"Decoupled antigen binding and CD3 signalling in allogeneic T cells969This issue highlights the engineering of T cells and other immunomodulatory therapeutic cells with augmented functionality, for use to treat HIV, cancers, red-blood-cell disorders and injured, inflamed tissue.970The cover illustrates that allogeneic T cells can be engineered with a T cell receptor that decouples antigen-mediated T cell activation from T cell cytotoxicity.971See Kapetanovic et al.972Image: Daniel Pöschl, ETH Zurich. Cover design: Alex Wing.",C,MAC_Bench/Nature/Cover/Nature Biomedical Engineering/6_12.png,MAC_Bench/Nature/Cover/Nature Biomedical Engineering/6_12.png,clip,6_12.txt,MAC_Bench/Nature/Cover/Nature Biomedical Engineering/3_7.png,MAC_Bench/Nature/Cover/Nature Biomedical Engineering/3_7.png,ave_3,3_7.txt,MAC_Bench/Nature/Cover/Nature Biomedical Engineering/8_1.png,MAC_Bench/Nature/Cover/Nature Biomedical Engineering/8_1.png,groundtruth,8_1.txt,MAC_Bench/Nature/Cover/Nature Biomedical Engineering/3_4.png,MAC_Bench/Nature/Cover/Nature Biomedical Engineering/3_4.png,ave_2,3_4.txt,test973Trends in Cognitive Sciences,28_1,Which of the following options best describe the cover story?,"Is a cognitive science of dreaming possible? In this issue of Trends in Cognitive974 Sciences, Remington Mallett and colleagues address the historical barriers and recent975advancements in dream research, focusing on the challenges of objective observation976and977the limitations of retrospective recall. The authors highlight innovative methodologies,978such as979content decoding and real-time reporting, that enhance our understanding of dream980content981and its neural correlates. They also examine the potential of dream engineering techniques982to manipulate dream experiences for therapeutic and experimental purposes. By promoting983interdisciplinary approaches, this work sets the stage for a new era in dream science.984Cover art by Carmen Mancuso.",D,MAC_Bench/Cell/Cover/Trends in Cognitive Sciences/28_3.png,MAC_Bench/Cell/Cover/Trends in Cognitive Sciences/28_3.png,clip,28_3.txt,MAC_Bench/Cell/Cover/Trends in Cognitive Sciences/25_6.png,MAC_Bench/Cell/Cover/Trends in Cognitive Sciences/25_6.png,vith,25_6.txt,MAC_Bench/Cell/Cover/Trends in Cognitive Sciences/22_9.png,MAC_Bench/Cell/Cover/Trends in Cognitive Sciences/22_9.png,ave_2,22_9.txt,MAC_Bench/Cell/Cover/Trends in Cognitive Sciences/28_1.png,MAC_Bench/Cell/Cover/Trends in Cognitive Sciences/28_1.png,groundtruth,28_1.txt,train985Nature Reviews Endocrinology,20_10,Which of the following options best describe the cover story?,"Health equity in endocrinology, inspired by the Viewpoint on p130.986Cover design: Jennie Vallis",D,MAC_Bench/Nature/Cover/Nature Reviews Endocrinology/19_9.png,MAC_Bench/Nature/Cover/Nature Reviews Endocrinology/19_9.png,vith,19_9.txt,MAC_Bench/Nature/Cover/Nature Reviews Endocrinology/20_11.png,MAC_Bench/Nature/Cover/Nature Reviews Endocrinology/20_11.png,vitg,20_11.txt,MAC_Bench/Nature/Cover/Nature Reviews Endocrinology/20_2.png,MAC_Bench/Nature/Cover/Nature Reviews Endocrinology/20_2.png,clip,20_2.txt,MAC_Bench/Nature/Cover/Nature Reviews Endocrinology/20_10.png,MAC_Bench/Nature/Cover/Nature Reviews Endocrinology/20_10.png,groundtruth,20_10.txt,train987NATURE IMMUNOLOGY,25_1,Which of the following options best describe the cover story?,"Sentinel macrophage–nociceptor crosstalk988Why joints are highly responsive to systemic inflammation is unknown. Hasegawa et al. sought to address this question, developing a whole-mount imaging system of the entire synovium to profile the vascular, neuronal and immune components.989See Hasegawa et al.990Image credit: Tetsuo Hasegawa, University of Cambridge. Cover design: Vanitha Selvarajan",B,MAC_Bench/Nature/Cover/NATURE IMMUNOLOGY/24_3.png,MAC_Bench/Nature/Cover/NATURE IMMUNOLOGY/24_3.png,vith,24_3.txt,MAC_Bench/Nature/Cover/NATURE IMMUNOLOGY/25_1.png,MAC_Bench/Nature/Cover/NATURE IMMUNOLOGY/25_1.png,groundtruth,25_1.txt,MAC_Bench/Nature/Cover/NATURE IMMUNOLOGY/17_11.png,MAC_Bench/Nature/Cover/NATURE IMMUNOLOGY/17_11.png,clip,17_11.txt,MAC_Bench/Nature/Cover/NATURE IMMUNOLOGY/24_6.png,MAC_Bench/Nature/Cover/NATURE IMMUNOLOGY/24_6.png,vitg,24_6.txt,train991CELL RESEARCH,34_3,Which of the following options best describe the cover story?,"The image depicts a story that happened during the Warring States. A senior general named Lian Po, loyal to King of the Zhao State, was given a chunk of meat and became re-energized. The cover paper reports that the catabolism of the amino acid glutamine can replenish energy when glucose is depleted. See page 683–706 by Mengqi Li et al. for details.",A,MAC_Bench/Nature/Cover/CELL RESEARCH/34_3.png,MAC_Bench/Nature/Cover/CELL RESEARCH/34_3.png,groundtruth,34_3.txt,MAC_Bench/Nature/Cover/CELL RESEARCH/34_4.png,MAC_Bench/Nature/Cover/CELL RESEARCH/34_4.png,vitg,34_4.txt,MAC_Bench/Nature/Cover/CELL RESEARCH/34_5.png,MAC_Bench/Nature/Cover/CELL RESEARCH/34_5.png,clip,34_5.txt,MAC_Bench/Nature/Cover/CELL RESEARCH/34_7.png,MAC_Bench/Nature/Cover/CELL RESEARCH/34_7.png,ave_2,34_7.txt,train992Nature Synthesis,3_2,Which of the following options best describe the cover story?,"Enzymatic enone synthesis993Chiral enones are produced, using flavin-dependent ene-reductases, through a desymmetrization approach. Enzymatic desaturation and reduction processes enable the synthesis of either enantiomer of the enone products from cyclohexanone or cyclohexadienone substrates.994See Zeng et al.995Image: Mudi Wang, National Institute of Biological Sciences. Cover design: Thomas Phillips",B,MAC_Bench/Nature/Cover/Nature Synthesis/1_8.png,MAC_Bench/Nature/Cover/Nature Synthesis/1_8.png,clip,1_8.txt,MAC_Bench/Nature/Cover/Nature Synthesis/3_2.png,MAC_Bench/Nature/Cover/Nature Synthesis/3_2.png,groundtruth,3_2.txt,MAC_Bench/Nature/Cover/Nature Synthesis/3_11.png,MAC_Bench/Nature/Cover/Nature Synthesis/3_11.png,vitg,3_11.txt,MAC_Bench/Nature/Cover/Nature Synthesis/1_2.png,MAC_Bench/Nature/Cover/Nature Synthesis/1_2.png,ave_2,1_2.txt,train996Nature Cities,1_3,Which of the following options best describe the cover story?,"Quantifying 15-minute cities997Quantifying the potential to achieve 15-minute cities, Bruno et al. measure the proximity time to access essential services and amenities across global cities. The 3D maps of Rome, Fortaleza, Nairobi, Mumbai, Hanoi and Bogotá show population density as the height of the bars, and blue, yellow and red as high, medium and low levels of accessibility.998See Bruno et al.999Image: Matteo Bruno, Sony Computer Science Laboratories - Rome. Hygor Piaget Monteiro Melo, Sony Computer Science Laboratories – Rome. Cover design: Lauren Heslop.",B,MAC_Bench/Nature/Cover/Nature Cities/2_1.png,MAC_Bench/Nature/Cover/Nature Cities/2_1.png,vitg,2_1.txt,MAC_Bench/Nature/Cover/Nature Cities/1_3.png,MAC_Bench/Nature/Cover/Nature Cities/1_3.png,groundtruth,1_3.txt,MAC_Bench/Nature/Cover/Nature Cities/1_4.png,MAC_Bench/Nature/Cover/Nature Cities/1_4.png,ave_2,1_4.txt,MAC_Bench/Nature/Cover/Nature Cities/1_8.png,MAC_Bench/Nature/Cover/Nature Cities/1_8.png,clip,1_8.txt,train1000Trends in Chemistry,6_11,Which of the following options best describe the cover story?,"Developing new medicines requires a huge amount of time, effort and1001money to bring them to market, not to mention the negative environmental impacts1002from the synthetic routes and chemicals used. All of these costs are then passed1003onto the consumers - therefore those in low/limited income countries worldwide have1004reduced access to life-saving medications that are sorely needed. In his Opinion1005article, Professor Bruce Lipshutz makes the case that adhering to the Principles of1006Green Chemistry, alongside new green technologies, can lead to more environmentally1007responsible and cost-effective synthetic routes for manufacturing vital drug molecules,1008benefitting the health and well-being of many across the globe. Image credit: Getty1009Images/artpartner-images",B,MAC_Bench/Cell/Cover/Trends in Chemistry/1_12.png,MAC_Bench/Cell/Cover/Trends in Chemistry/1_12.png,clip,1_12.txt,MAC_Bench/Cell/Cover/Trends in Chemistry/6_11.png,MAC_Bench/Cell/Cover/Trends in Chemistry/6_11.png,groundtruth,6_11.txt,MAC_Bench/Cell/Cover/Trends in Chemistry/5_12.png,MAC_Bench/Cell/Cover/Trends in Chemistry/5_12.png,vitg,5_12.txt,MAC_Bench/Cell/Cover/Trends in Chemistry/6_4.png,MAC_Bench/Cell/Cover/Trends in Chemistry/6_4.png,vith,6_4.txt,train1010Nature Cities,1_8,Which of the following options best describe the cover story?,"Assessing building damage from war1011Quantifying building damage during war is difficult but key for understanding its extent and for determining the rebuilding efforts required. This study uses a satellite imaging technique to focus on building damage in Syrian and Ukrainian cities.1012See Hou et al.1013Image: Naeblys / Alamy Stock Photo. Cover design: Lauren Heslop",A,MAC_Bench/Nature/Cover/Nature Cities/1_8.png,MAC_Bench/Nature/Cover/Nature Cities/1_8.png,groundtruth,1_8.txt,MAC_Bench/Nature/Cover/Nature Cities/2_1.png,MAC_Bench/Nature/Cover/Nature Cities/2_1.png,ave_3,2_1.txt,MAC_Bench/Nature/Cover/Nature Cities/1_11.png,MAC_Bench/Nature/Cover/Nature Cities/1_11.png,ave_2,1_11.txt,MAC_Bench/Nature/Cover/Nature Cities/1_10.png,MAC_Bench/Nature/Cover/Nature Cities/1_10.png,clip,1_10.txt,train1014Nature Machine Intelligence,6_10,Which of the following options best describe the cover story?,"Learning phenotypes from cardiac geometry1015Understanding the genetic factors that underlie the normal variation in cardiac shape is of great interest. In this work, Bonazzola et al. apply unsupervised geometric deep learning to phenotype the left ventricle by using an MRI-derived three-dimensional mesh representation (as depicted on the cover). The authors show that this approach boosts genetic discovery and provides deeper insights into the genetic underpinnings of cardiac morphology.1016See Bonazzola et al.1017Image: Rodrigo Bonazzola, University of Leeds. Cover design: Amie Fernandez",D,MAC_Bench/Nature/Cover/Nature Machine Intelligence/6_7.png,MAC_Bench/Nature/Cover/Nature Machine Intelligence/6_7.png,vitg,6_7.txt,MAC_Bench/Nature/Cover/Nature Machine Intelligence/2_10.png,MAC_Bench/Nature/Cover/Nature Machine Intelligence/2_10.png,clip,2_10.txt,MAC_Bench/Nature/Cover/Nature Machine Intelligence/4_8.png,MAC_Bench/Nature/Cover/Nature Machine Intelligence/4_8.png,ave_3,4_8.txt,MAC_Bench/Nature/Cover/Nature Machine Intelligence/6_10.png,MAC_Bench/Nature/Cover/Nature Machine Intelligence/6_10.png,groundtruth,6_10.txt,train1018NATURE REVIEWS MOLECULAR CELL BIOLOGY,25_12,Which of the following options best describe the cover story?,"‘The power of antioxidants’, inspired by the Review on p131019Cover design: Vicky Summersby",D,MAC_Bench/Nature/Cover/NATURE REVIEWS MOLECULAR CELL BIOLOGY/25_9.png,MAC_Bench/Nature/Cover/NATURE REVIEWS MOLECULAR CELL BIOLOGY/25_9.png,vith,25_9.txt,MAC_Bench/Nature/Cover/NATURE REVIEWS MOLECULAR CELL BIOLOGY/24_10.png,MAC_Bench/Nature/Cover/NATURE REVIEWS MOLECULAR CELL BIOLOGY/24_10.png,ave_3,24_10.txt,MAC_Bench/Nature/Cover/NATURE REVIEWS MOLECULAR CELL BIOLOGY/25_3.png,MAC_Bench/Nature/Cover/NATURE REVIEWS MOLECULAR CELL BIOLOGY/25_3.png,clip,25_3.txt,MAC_Bench/Nature/Cover/NATURE REVIEWS MOLECULAR CELL BIOLOGY/25_12.png,MAC_Bench/Nature/Cover/NATURE REVIEWS MOLECULAR CELL BIOLOGY/25_12.png,groundtruth,25_12.txt,train1020One Earth,7_1,Which of the following options best describe the cover story?,"On the cover: Soil, the earth beneath our feet, provides essential ecological services1021for all life on Earth, but it is under immense pressure from anthropogenic activities.1022Yet before we can effectively manage, protect, and restore our soils, we must first1023develop a comprehensive understanding of soil health. Getty, Kami (Kuo, Jia-Wei).",D,MAC_Bench/Cell/Cover/One Earth/7_10.png,MAC_Bench/Cell/Cover/One Earth/7_10.png,clip,7_10.txt,MAC_Bench/Cell/Cover/One Earth/6_11.png,MAC_Bench/Cell/Cover/One Earth/6_11.png,vith,6_11.txt,MAC_Bench/Cell/Cover/One Earth/5_11.png,MAC_Bench/Cell/Cover/One Earth/5_11.png,vitg,5_11.txt,MAC_Bench/Cell/Cover/One Earth/7_1.png,MAC_Bench/Cell/Cover/One Earth/7_1.png,groundtruth,7_1.txt,train1024Nature Mental Health,2_10,Which of the following options best describe the cover story?,"Loneliness and social isolation1025The cover of the March issue focuses on the issue of the experience of loneliness and social isolation that can occur even when one is surrounded by others. Research investigating these constructs considers the nuances of the subjective and objective dimensions — where loneliness refers to the distress that arises from feeling one does not have enough fulfilling social contact, and social isolation refers to the limited number and quality of social contacts. Notably, both are associated with poor physical and mental health. Finding ways to disrupt the feeling of loneliness and experiencing social isolation is crucial for protecting vulnerable people, such as adolescents and older adults.1026Read more in our Editorial, and see Benedyk et al. on the effects of physical activity on loneliness and social isolation.1027Image and cover design: Debbie Maizels",C,MAC_Bench/Nature/Cover/Nature Mental Health/1_10.png,MAC_Bench/Nature/Cover/Nature Mental Health/1_10.png,clip,1_10.txt,MAC_Bench/Nature/Cover/Nature Mental Health/2_3.png,MAC_Bench/Nature/Cover/Nature Mental Health/2_3.png,vith,2_3.txt,MAC_Bench/Nature/Cover/Nature Mental Health/2_10.png,MAC_Bench/Nature/Cover/Nature Mental Health/2_10.png,groundtruth,2_10.txt,MAC_Bench/Nature/Cover/Nature Mental Health/2_11.png,MAC_Bench/Nature/Cover/Nature Mental Health/2_11.png,vitg,2_11.txt,train1028Nature Reviews Psychology,3_9,Which of the following options best describe the cover story?,"Sounds are generated by interactions between objects in the world. In this Review, Winkler & Denham describe how representations of sources and actions enable humans to segment complex auditory experience into meaningful units.1029Cover design: David Johnston",A,MAC_Bench/Nature/Cover/Nature Reviews Psychology/3_9.png,MAC_Bench/Nature/Cover/Nature Reviews Psychology/3_9.png,groundtruth,3_9.txt,MAC_Bench/Nature/Cover/Nature Reviews Psychology/3_3.png,MAC_Bench/Nature/Cover/Nature Reviews Psychology/3_3.png,vitg,3_3.txt,MAC_Bench/Nature/Cover/Nature Reviews Psychology/2_10.png,MAC_Bench/Nature/Cover/Nature Reviews Psychology/2_10.png,clip,2_10.txt,MAC_Bench/Nature/Cover/Nature Reviews Psychology/3_10.png,MAC_Bench/Nature/Cover/Nature Reviews Psychology/3_10.png,vith,3_10.txt,train1030Nature Water,2_1,Which of the following options best describe the cover story?,"A socioeconomic view of antimicrobials1031Monitoring the use of antimicrobial agents is a necessary step to find solutions to the emergence of antimicrobial resistance. One aspect that is rarely investigated is the connection of antimicrobial concentration with the socioeconomic status of the population. The image on the cover shows a heatmap illustrating per capita excreted loads of 56 detected antimicrobials and their transformation products, as reflected in wastewater influent from 50 wastewater treatment plants (WWTPs) across Australia. Each WWTP is characterized by varying population sizes, geographical remoteness, and socioeconomic statuses. The notable variation in antimicrobial excreted loads indicates diverse antimicrobial use behaviours among different populations in Australia.1032See Li et al.1033Image: Jinglong Li, The University of Queensland. Cover design: Laoise Mac Gabhann",D,MAC_Bench/Nature/Cover/Nature Water/1_1.png,MAC_Bench/Nature/Cover/Nature Water/1_1.png,ave_3,1_1.txt,MAC_Bench/Nature/Cover/Nature Water/2_7.png,MAC_Bench/Nature/Cover/Nature Water/2_7.png,clip,2_7.txt,MAC_Bench/Nature/Cover/Nature Water/1_8.png,MAC_Bench/Nature/Cover/Nature Water/1_8.png,vith,1_8.txt,MAC_Bench/Nature/Cover/Nature Water/2_1.png,MAC_Bench/Nature/Cover/Nature Water/2_1.png,groundtruth,2_1.txt,train1034Journal of the American Chemical Society,2024_7,Which of the following options best describe the cover story?,A light-emitting diode based on an organic polymer crystal generates circular-polarized emission from topological photonic valleys. It can be used for virtual reality and 3D displays.,A,MAC_Bench/ACS/Cover/Journal of the American Chemical Society/2024_7.png,MAC_Bench/ACS/Cover/Journal of the American Chemical Society/2024_7.png,groundtruth,2024_7.txt,MAC_Bench/ACS/Cover/Journal of the American Chemical Society/2024_11.png,MAC_Bench/ACS/Cover/Journal of the American Chemical Society/2024_11.png,vitg,2024_11.txt,MAC_Bench/ACS/Cover/Journal of the American Chemical Society/2018_3.png,MAC_Bench/ACS/Cover/Journal of the American Chemical Society/2018_3.png,clip,2018_3.txt,MAC_Bench/ACS/Cover/Journal of the American Chemical Society/2021_12.png,MAC_Bench/ACS/Cover/Journal of the American Chemical Society/2021_12.png,vith,2021_12.txt,test1035Cell Host&Microbe,32_2,Which of the following options best describe the cover story?,"On the cover: The cover is a Chinese ink wash painting depicting bees collecting pollens1036from plum blossoms, which symbolize wisdom in Chinese traditional culture. In this1037issue of Cell Host & Microbe, Zhong et al. reveal that honeybee gut microbiota influence reward learning by mediating the metabolism1038of pollen fatty acids. Bacteria facilitates the conversion of linoleic acid to anandamide,1039which activates TRPA receptors in astrocytes. This triggers the endocannabinoid system1040and regulates glutamate/GABA balance in bee brain, ultimately enhancing honeybee reward1041learning and memory.",C,MAC_Bench/Cell/Cover/Cell Host&Microbe/30_10.png,MAC_Bench/Cell/Cover/Cell Host&Microbe/30_10.png,vitg,30_10.txt,MAC_Bench/Cell/Cover/Cell Host&Microbe/32_8.png,MAC_Bench/Cell/Cover/Cell Host&Microbe/32_8.png,clip,32_8.txt,MAC_Bench/Cell/Cover/Cell Host&Microbe/32_2.png,MAC_Bench/Cell/Cover/Cell Host&Microbe/32_2.png,groundtruth,32_2.txt,MAC_Bench/Cell/Cover/Cell Host&Microbe/31_1.png,MAC_Bench/Cell/Cover/Cell Host&Microbe/31_1.png,vith,31_1.txt,val1042Nature Protocols,20_1,Which of the following options best describe the cover story?,"A bioswitchable delivery system for miRNA therapeutics1043This image illustrates a bioswitchable delivery system designed to achieve controlled loading and release of miRNA regulators. A ribonuclease H-sensitive sequence functions as the bioswitchable apparatus, enabling release of the miRNA regulator upon ribonuclease H binding (green). See Li et al.1044Image: Yunfeng Lin and Songhang Li, Sichuan University. Cover design: S. Harris.",A,MAC_Bench/Nature/Cover/Nature Protocols/20_1.png,MAC_Bench/Nature/Cover/Nature Protocols/20_1.png,groundtruth,20_1.txt,MAC_Bench/Nature/Cover/Nature Protocols/19_5.png,MAC_Bench/Nature/Cover/Nature Protocols/19_5.png,clip,19_5.txt,MAC_Bench/Nature/Cover/Nature Protocols/16_3.png,MAC_Bench/Nature/Cover/Nature Protocols/16_3.png,ave_3,16_3.txt,MAC_Bench/Nature/Cover/Nature Protocols/19_6.png,MAC_Bench/Nature/Cover/Nature Protocols/19_6.png,ave_2,19_6.txt,train1045Developmental Cell,59_6,Which of the following options best describe the cover story?,"On the cover: This is a confocal image of 5-day-old etiolated hypocotyls of an Arabidopsis thaliana mutant (mus3) with large aggregations of endomembrane components and plant cell wall polysaccharides1046(in cyan: labeled with a membrane-associated dye, FM4-64, that is internalized by1047endocytosis). Here, the authors demonstrate that sidechain addition to xyloglucan1048polysaccharides is required for efficient packaging and secretion of polysaccharides1049to the plant cell wall. To learn more about how polysaccharide structure affects transport1050to the plant cell wall, see Hoffmann and McFarlane. Image credit: Natalie Hoffmann.",C,MAC_Bench/Cell/Cover/Developmental Cell/57_1.png,MAC_Bench/Cell/Cover/Developmental Cell/57_1.png,vitg,57_1.txt,MAC_Bench/Cell/Cover/Developmental Cell/58_22.png,MAC_Bench/Cell/Cover/Developmental Cell/58_22.png,vith,58_22.txt,MAC_Bench/Cell/Cover/Developmental Cell/59_6.png,MAC_Bench/Cell/Cover/Developmental Cell/59_6.png,groundtruth,59_6.txt,MAC_Bench/Cell/Cover/Developmental Cell/58_8.png,MAC_Bench/Cell/Cover/Developmental Cell/58_8.png,clip,58_8.txt,train1051Nature Computational Science,4_2,Which of the following options best describe the cover story?,"Impact of generative AI on e-waste1052The rising popularity and usage of generative artificial intelligence (AI) amongst the general public and for research purposes has contributed to an increase in electronic waste (e-waste). In this issue, Peng Wang and colleagues propose a computational framework to quantify the amount of e-waste that is produced by generative AI, particularly large language models, highlighting the potential for rapid e-waste growth under different scenarios and emphasizing the need for circular economies and proactive e-waste management strategies.1053See Peng Wang et al. and Loïc Lannelongue1054Image: Guillaume Payen / LightRocket / Getty Images. Cover design: Alex Wing.",A,MAC_Bench/Nature/Cover/Nature Computational Science/4_2.png,MAC_Bench/Nature/Cover/Nature Computational Science/4_2.png,groundtruth,4_2.txt,MAC_Bench/Nature/Cover/Nature Computational Science/1_2.png,MAC_Bench/Nature/Cover/Nature Computational Science/1_2.png,vitg,1_2.txt,MAC_Bench/Nature/Cover/Nature Computational Science/1_3.png,MAC_Bench/Nature/Cover/Nature Computational Science/1_3.png,ave_3,1_3.txt,MAC_Bench/Nature/Cover/Nature Computational Science/4_8.png,MAC_Bench/Nature/Cover/Nature Computational Science/4_8.png,clip,4_8.txt,test1055Journal of Medicinal Chemistry,2024_2,Which of the following options best describe the cover story?,"This cover depicts a promising approach in drug discovery for the treatment of Alzheimer’s disease. Via phenotypic discovery of triple-target combinations with synergistic effects on microglia, an in silico restricted fragment docking strategy was developed to achieve “three birds with one stone”. The optimal ligand showed in vitro and in vivo efficacy by precisely modulating targets of interest. View the article.",C,MAC_Bench/ACS/Cover/Journal of Medicinal Chemistry/1997_15.png,MAC_Bench/ACS/Cover/Journal of Medicinal Chemistry/1997_15.png,clip,1997_15.txt,MAC_Bench/ACS/Cover/Journal of Medicinal Chemistry/2014_24.png,MAC_Bench/ACS/Cover/Journal of Medicinal Chemistry/2014_24.png,vith,2014_24.txt,MAC_Bench/ACS/Cover/Journal of Medicinal Chemistry/2024_2.png,MAC_Bench/ACS/Cover/Journal of Medicinal Chemistry/2024_2.png,groundtruth,2024_2.txt,MAC_Bench/ACS/Cover/Journal of Medicinal Chemistry/2024_12.png,MAC_Bench/ACS/Cover/Journal of Medicinal Chemistry/2024_12.png,vitg,2024_12.txt,test1056Nature Reviews Physics,6_9,Which of the following options best describe the cover story?,"The cover of this issue illustrates living human cancer cells and tissues. See Massey et al.1057Image: Alexander Cartagena-Rivera, National Institutes of Health, US. Cover design: Susanne Harris.",C,MAC_Bench/Nature/Cover/Nature Reviews Physics/6_1.png,MAC_Bench/Nature/Cover/Nature Reviews Physics/6_1.png,vith,6_1.txt,MAC_Bench/Nature/Cover/Nature Reviews Physics/6_3.png,MAC_Bench/Nature/Cover/Nature Reviews Physics/6_3.png,vitg,6_3.txt,MAC_Bench/Nature/Cover/Nature Reviews Physics/6_9.png,MAC_Bench/Nature/Cover/Nature Reviews Physics/6_9.png,groundtruth,6_9.txt,MAC_Bench/Nature/Cover/Nature Reviews Physics/5_6.png,MAC_Bench/Nature/Cover/Nature Reviews Physics/5_6.png,clip,5_6.txt,test1058Joule,8_11,Which of the following options best describe the cover story?,"On the cover: Zhang et al. develop a universal encapsulation method for commercialized perovskite solar cell1059(PSC). The encapsulated PSC modules passed outdoor stability, UV preconditioning,1060and hail tests according to the International Electrotechnical Commission 61215 standard.1061Image credit: Guodong Zhang, Yifan Zheng, and Yuchuan Shao.",C,MAC_Bench/Cell/Cover/Joule/8_6.png,MAC_Bench/Cell/Cover/Joule/8_6.png,clip,8_6.txt,MAC_Bench/Cell/Cover/Joule/3_2.png,MAC_Bench/Cell/Cover/Joule/3_2.png,vitg,3_2.txt,MAC_Bench/Cell/Cover/Joule/8_11.png,MAC_Bench/Cell/Cover/Joule/8_11.png,groundtruth,8_11.txt,MAC_Bench/Cell/Cover/Joule/7_7.png,MAC_Bench/Cell/Cover/Joule/7_7.png,vith,7_7.txt,val1062One Earth,7_7,Which of the following options best describe the cover story?,"On the cover: This month's cover features Suze Woolf’s artwork Larger Than Life from her series of “burned tree portraits.” By realizing that a paper substrate can1063be any shape, including the contour of a burned tree, Suze works on torn paper to1064represent the state of the forests. The paintings are both a metaphor for and an example1065of our human impact on nature: our prediliction for cooking the planet. The artwork1066featured on this month's cover illustrates the topography of fire-carved layers of1067lignin, from the Tripod burn on Tiffany Mountain in Washington State's Pasayten Wilderness.1068The patterns reminded Suze of the swoops and swirls of '60s acid rock music posters.1069Cover by Suze Woolf https://www.suzewoolf-fineart.com/, courtesy of the artist.",C,MAC_Bench/Cell/Cover/One Earth/3_6.png,MAC_Bench/Cell/Cover/One Earth/3_6.png,clip,3_6.txt,MAC_Bench/Cell/Cover/One Earth/5_11.png,MAC_Bench/Cell/Cover/One Earth/5_11.png,vitg,5_11.txt,MAC_Bench/Cell/Cover/One Earth/7_7.png,MAC_Bench/Cell/Cover/One Earth/7_7.png,groundtruth,7_7.txt,MAC_Bench/Cell/Cover/One Earth/6_10.png,MAC_Bench/Cell/Cover/One Earth/6_10.png,vith,6_10.txt,train1070NATURE REVIEWS DRUG DISCOVERY,24_2,Which of the following options best describe the cover story?,"N-of-1 therapies, inspired by the Review on p40.1071Cover design: S. Harris",B,MAC_Bench/Nature/Cover/NATURE REVIEWS DRUG DISCOVERY/24_1.png,MAC_Bench/Nature/Cover/NATURE REVIEWS DRUG DISCOVERY/24_1.png,clip,24_1.txt,MAC_Bench/Nature/Cover/NATURE REVIEWS DRUG DISCOVERY/24_2.png,MAC_Bench/Nature/Cover/NATURE REVIEWS DRUG DISCOVERY/24_2.png,groundtruth,24_2.txt,MAC_Bench/Nature/Cover/NATURE REVIEWS DRUG DISCOVERY/23_12.png,MAC_Bench/Nature/Cover/NATURE REVIEWS DRUG DISCOVERY/23_12.png,ave_2,23_12.txt,MAC_Bench/Nature/Cover/NATURE REVIEWS DRUG DISCOVERY/22_9.png,MAC_Bench/Nature/Cover/NATURE REVIEWS DRUG DISCOVERY/22_9.png,ave_3,22_9.txt,train1072ACS Applied Polymer Materials,2024_4,Which of the following options best describe the cover story?,This cover illustration shows superior thermal conducting properties of newly developed liquid crystal (LC) materials derived from improved molecular orientation by polymerization. LC epoxy resins exhibit high thermal conductivity based on mesogen networks oriented by intermolecular interactions with excellent potential as electronic materials.,C,MAC_Bench/ACS/Cover/ACS Applied Polymer Materials/2024_14.png,MAC_Bench/ACS/Cover/ACS Applied Polymer Materials/2024_14.png,clip,2024_14.txt,MAC_Bench/ACS/Cover/ACS Applied Polymer Materials/2023_5.png,MAC_Bench/ACS/Cover/ACS Applied Polymer Materials/2023_5.png,vith,2023_5.txt,MAC_Bench/ACS/Cover/ACS Applied Polymer Materials/2024_4.png,MAC_Bench/ACS/Cover/ACS Applied Polymer Materials/2024_4.png,groundtruth,2024_4.txt,MAC_Bench/ACS/Cover/ACS Applied Polymer Materials/2022_4.png,MAC_Bench/ACS/Cover/ACS Applied Polymer Materials/2022_4.png,vitg,2022_4.txt,test1073Chem & Bio Engineering,2024_7,Which of the following options best describe the cover story?,The membranes made from light-responsive ionic covalent-organic frameworks show improved ionic power generation by capitalizing on the synergistic effects of solar energy and salinity gradients.,C,MAC_Bench/ACS/Cover/Chem & Bio Engineering/2024_8.png,MAC_Bench/ACS/Cover/Chem & Bio Engineering/2024_8.png,clip,2024_8.txt,MAC_Bench/ACS/Cover/Chem & Bio Engineering/2024_5.png,MAC_Bench/ACS/Cover/Chem & Bio Engineering/2024_5.png,ave_2,2024_5.txt,MAC_Bench/ACS/Cover/Chem & Bio Engineering/2024_7.png,MAC_Bench/ACS/Cover/Chem & Bio Engineering/2024_7.png,groundtruth,2024_7.txt,MAC_Bench/ACS/Cover/Chem & Bio Engineering/2024_6.png,MAC_Bench/ACS/Cover/Chem & Bio Engineering/2024_6.png,vitg,2024_6.txt,train1074Organic Letters,2025_5,Which of the following options best describe the cover story?,"The cover picture inspired by the Lantern Festival in China. Cyclopropenone and allyl alcohol/olefin are like fireworks, while radicals are like fuses. Their combination and collision can produce",C,MAC_Bench/ACS/Cover/Organic Letters/2025_2.png,MAC_Bench/ACS/Cover/Organic Letters/2025_2.png,ave_3,2025_2.txt,MAC_Bench/ACS/Cover/Organic Letters/2023_47.png,MAC_Bench/ACS/Cover/Organic Letters/2023_47.png,clip,2023_47.txt,MAC_Bench/ACS/Cover/Organic Letters/2025_5.png,MAC_Bench/ACS/Cover/Organic Letters/2025_5.png,groundtruth,2025_5.txt,MAC_Bench/ACS/Cover/Organic Letters/2023_49.png,MAC_Bench/ACS/Cover/Organic Letters/2023_49.png,vitg,2023_49.txt,train1075Macromolecules,2024_2,Which of the following options best describe the cover story?,Molecular dynamics simulations of crazes in glassy polymers under cyclic loading reveal the quasi-stress-free motion of craze fibril folding during unloading. View the article.,A,MAC_Bench/ACS/Cover/Macromolecules/2024_2.png,MAC_Bench/ACS/Cover/Macromolecules/2024_2.png,groundtruth,2024_2.txt,MAC_Bench/ACS/Cover/Macromolecules/2023_19.png,MAC_Bench/ACS/Cover/Macromolecules/2023_19.png,vitg,2023_19.txt,MAC_Bench/ACS/Cover/Macromolecules/2020_3.png,MAC_Bench/ACS/Cover/Macromolecules/2020_3.png,clip,2020_3.txt,MAC_Bench/ACS/Cover/Macromolecules/2015_20.png,MAC_Bench/ACS/Cover/Macromolecules/2015_20.png,vith,2015_20.txt,train1076Nature Chemistry,16_3,Which of the following options best describe the cover story?,"Solid-state superionic conductivity1077All-solid-state batteries offer a safer alternative to conventional lithium-ion batteries, but the solid electrolytes necessary to transport lithium ions between electrodes display poor room-temperature conductivities. Now, Jue Liu, Yifei Mo, and Hailong Chen show how a family of electrolyte solids undergo a temperature-triggered transition from low to high conductivities due to collective anion motion. Using the uncovered structure–property relationships, they develop new electrolytes with lower transition temperatures to achieve superionic conductivities at room temperature. The cover shows an artistic representation of lithium-ion movement through the solid-state electrolyte.1078See Chen et al.1079Image: Phoenix Pleasant / ORNL, U.S. Dept. of Energy. Cover design: Tulsi Voralia",C,MAC_Bench/Nature/Cover/Nature Chemistry/16_8.png,MAC_Bench/Nature/Cover/Nature Chemistry/16_8.png,clip,16_8.txt,MAC_Bench/Nature/Cover/Nature Chemistry/14_7.png,MAC_Bench/Nature/Cover/Nature Chemistry/14_7.png,vitg,14_7.txt,MAC_Bench/Nature/Cover/Nature Chemistry/16_3.png,MAC_Bench/Nature/Cover/Nature Chemistry/16_3.png,groundtruth,16_3.txt,MAC_Bench/Nature/Cover/Nature Chemistry/13_3.png,MAC_Bench/Nature/Cover/Nature Chemistry/13_3.png,vith,13_3.txt,train1080Science Immunology,9_97,Which of the following options best describe the cover story?,"ONLINE COVER The Immunology of Human Schistosomiasis. Schistosomiasis is a parasitic disease caused by blood flukes in the genus Schistosoma. Humans are typically infected through agricultural, domestic, and fishing activities that expose them to contaminated water. Houlder et al. studied how the immune features of schistosomiasis change over time by tracking immune responses during acute human Schistosoma mansoni infections in a controlled experimental setting. The early stages of infection were dominated by an inflammatory type 1 T helper (TH1) cell–skewed response regardless of whether participants were infected with male or female cercariae-stage parasites. By 8 weeks, however, type 2 T helper (TH2) and T regulatory (Treg) cells dominated the response, consistent with chronic schistosomiasis. This month’s cover features fishermen on Lake Malawi near Cape Maclear, Malawi, a site endemic for schistosomiasis. Credit: Robert Harding Picture Libr. Ltd/Getty Images",A,MAC_Bench/Science/Cover/Science Immunology/9_97.png,MAC_Bench/Science/Cover/Science Immunology/9_97.png,groundtruth,9_97.txt,MAC_Bench/Science/Cover/Science Immunology/3_23.png,MAC_Bench/Science/Cover/Science Immunology/3_23.png,clip,3_23.txt,MAC_Bench/Science/Cover/Science Immunology/7_73.png,MAC_Bench/Science/Cover/Science Immunology/7_73.png,vitg,7_73.txt,MAC_Bench/Science/Cover/Science Immunology/8_86.png,MAC_Bench/Science/Cover/Science Immunology/8_86.png,vith,8_86.txt,train1081Environment & Health,2024_11,Which of the following options best describe the cover story?,"This image shows that two routes (IVI and INI) of silica nanoparticle exposure resulted in different outcomes of brain damage. The Baidu Wenxin Yige platform was used to improve the cover image, drawn using SAI software.",D,MAC_Bench/ACS/Cover/Environment & Health/2024_9.png,MAC_Bench/ACS/Cover/Environment & Health/2024_9.png,ave_3,2024_9.txt,MAC_Bench/ACS/Cover/Environment & Health/2025_2.png,MAC_Bench/ACS/Cover/Environment & Health/2025_2.png,vitg,2025_2.txt,MAC_Bench/ACS/Cover/Environment & Health/2025_1.png,MAC_Bench/ACS/Cover/Environment & Health/2025_1.png,clip,2025_1.txt,MAC_Bench/ACS/Cover/Environment & Health/2024_11.png,MAC_Bench/ACS/Cover/Environment & Health/2024_11.png,groundtruth,2024_11.txt,test1082Nature Neuroscience,27_8,Which of the following options best describe the cover story?,"Common chemicals harm oligodendrocytes.1083Chemicals in household products may affect brain development through direct toxic effects on oligodendrocytes, the myelinating cells in the central nervous system. These chemicals can be found in many consumer products, including hair conditioners, disinfecting wipes, and mouthwash. Because oligodendrocytes can develop and myelinate throughout childhood, the chemicals may pose a significant health risk to children. This image depicts a setting in which a child may be exposed to the identified chemicals. In this image, a myelinated neuron and oligodendrocytes float in the water of a bathtub, where they are covered in quaternary compounds.1084See Cohn et al.1085Image: Ella Maru Studio. Cover design: Marina Spence",D,MAC_Bench/Nature/Cover/Nature Neuroscience/25_11.png,MAC_Bench/Nature/Cover/Nature Neuroscience/25_11.png,clip,25_11.txt,MAC_Bench/Nature/Cover/Nature Neuroscience/25_9.png,MAC_Bench/Nature/Cover/Nature Neuroscience/25_9.png,vith,25_9.txt,MAC_Bench/Nature/Cover/Nature Neuroscience/27_4.png,MAC_Bench/Nature/Cover/Nature Neuroscience/27_4.png,vitg,27_4.txt,MAC_Bench/Nature/Cover/Nature Neuroscience/27_8.png,MAC_Bench/Nature/Cover/Nature Neuroscience/27_8.png,groundtruth,27_8.txt,train1086Journal of Medicinal Chemistry,2024_24,Which of the following options best describe the cover story?,"This cover art features a striking depiction of mitochondria emerging from a scientific paper adorned with illustrations of F0-ATPase and drugs. Scientists delve into groundbreaking research, seeking a cure for ischemia",C,MAC_Bench/ACS/Cover/Journal of Medicinal Chemistry/1997_15.png,MAC_Bench/ACS/Cover/Journal of Medicinal Chemistry/1997_15.png,clip,1997_15.txt,MAC_Bench/ACS/Cover/Journal of Medicinal Chemistry/2009_19.png,MAC_Bench/ACS/Cover/Journal of Medicinal Chemistry/2009_19.png,vith,2009_19.txt,MAC_Bench/ACS/Cover/Journal of Medicinal Chemistry/2024_24.png,MAC_Bench/ACS/Cover/Journal of Medicinal Chemistry/2024_24.png,groundtruth,2024_24.txt,MAC_Bench/ACS/Cover/Journal of Medicinal Chemistry/2024_12.png,MAC_Bench/ACS/Cover/Journal of Medicinal Chemistry/2024_12.png,vitg,2024_12.txt,train1087Nature Physics,20_6,Which of the following options best describe the cover story?,"Cell doublet pirouette1088Cells can pair up and form a rotating doublet. Linjie Lu and collaborators have shown that these rotations are spontaneously caused by an uneven distribution of myosin within cell cortices. This polarized distribution breaks the mirror symmetry of the doublet. These results highlight how active mechanical forces drive collective cell motion.1089See Lu et al.1090Image: Linjie Lu, Tristan Guyomar, and Daniel Riveline (IGBMC-University of Strasbourg). Cover design: Emily Paul",B,MAC_Bench/Nature/Cover/Nature Physics/19_5.png,MAC_Bench/Nature/Cover/Nature Physics/19_5.png,vith,19_5.txt,MAC_Bench/Nature/Cover/Nature Physics/20_6.png,MAC_Bench/Nature/Cover/Nature Physics/20_6.png,groundtruth,20_6.txt,MAC_Bench/Nature/Cover/Nature Physics/20_5.png,MAC_Bench/Nature/Cover/Nature Physics/20_5.png,clip,20_5.txt,MAC_Bench/Nature/Cover/Nature Physics/17_2.png,MAC_Bench/Nature/Cover/Nature Physics/17_2.png,vitg,17_2.txt,train1091Nature Chemical Engineering,1_9,Which of the following options best describe the cover story?,"Electrifying separation processes1092The recovery of valuable metals from waste sources remains challenging. Now, Xiao Su and colleagues demonstrate an electrochemical liquid–liquid extraction process that utilizes selective single-site binding of metal ions to a redox-active ferrocene in a continuously operating platform. This process achieved substantial up-concentration for gold and platinum group metals from several practical waste feedstocks.1093See Cotty et al. and Schuur1094Image: Stephen Cotty, University of Illinois Urbana-Champaign. Cover design: Thomas Phillips.",B,MAC_Bench/Nature/Cover/Nature Chemical Engineering/1_2.png,MAC_Bench/Nature/Cover/Nature Chemical Engineering/1_2.png,clip,1_2.txt,MAC_Bench/Nature/Cover/Nature Chemical Engineering/1_9.png,MAC_Bench/Nature/Cover/Nature Chemical Engineering/1_9.png,groundtruth,1_9.txt,MAC_Bench/Nature/Cover/Nature Chemical Engineering/1_3.png,MAC_Bench/Nature/Cover/Nature Chemical Engineering/1_3.png,ave_3,1_3.txt,MAC_Bench/Nature/Cover/Nature Chemical Engineering/1_11.png,MAC_Bench/Nature/Cover/Nature Chemical Engineering/1_11.png,ave_2,1_11.txt,train1095NATURE MATERIALS,23_8,Which of the following options best describe the cover story?,"Strain-induced electrocaloric1096Electrocaloric effects are large in a limited set of materials that display hysteretic first-order phase transitions. Here epitaxial SrTiO3 thin films are strain engineered to achieve anhysteretic second-order phase transitions, with electrocaloric effects enhanced by one order of magnitude over bulk.1097See Zhang et al.1098Image: BOTUHUI. Cover design: Alex Whitworth",D,MAC_Bench/Nature/Cover/NATURE MATERIALS/20_5.png,MAC_Bench/Nature/Cover/NATURE MATERIALS/20_5.png,vith,20_5.txt,MAC_Bench/Nature/Cover/NATURE MATERIALS/20_12.png,MAC_Bench/Nature/Cover/NATURE MATERIALS/20_12.png,clip,20_12.txt,MAC_Bench/Nature/Cover/NATURE MATERIALS/20_4.png,MAC_Bench/Nature/Cover/NATURE MATERIALS/20_4.png,vitg,20_4.txt,MAC_Bench/Nature/Cover/NATURE MATERIALS/23_8.png,MAC_Bench/Nature/Cover/NATURE MATERIALS/23_8.png,groundtruth,23_8.txt,train1099Nature Cancer,5_7,Which of the following options best describe the cover story?,"Targeting tumor vascularization1100De Palma and Hanahan outline the latest advances in understanding tumor angiogenesis and discuss therapeutic opportunities for targeting tumor vascularization.1101See De Palma and Hanahan1102Image: Mohammed Elamine ALIOUI / Alamy Stock Photo. Cover design: Allen Beattie",B,MAC_Bench/Nature/Cover/Nature Cancer/1_8.png,MAC_Bench/Nature/Cover/Nature Cancer/1_8.png,vith,1_8.txt,MAC_Bench/Nature/Cover/Nature Cancer/5_7.png,MAC_Bench/Nature/Cover/Nature Cancer/5_7.png,groundtruth,5_7.txt,MAC_Bench/Nature/Cover/Nature Cancer/4_3.png,MAC_Bench/Nature/Cover/Nature Cancer/4_3.png,clip,4_3.txt,MAC_Bench/Nature/Cover/Nature Cancer/5_8.png,MAC_Bench/Nature/Cover/Nature Cancer/5_8.png,ave_2,5_8.txt,train1103ACS Sustainable Chemistry & Engineering,2025_5,Which of the following options best describe the cover story?,"Ag-gCN nanocomposite catalysts were developed as copper-free alternatives for heterogeneous photocatalytic azide–alkyne cycloaddition reactions. The developed protocol shows a significant advancement in green chemistry, offering a sustainable, versatile, and efficient alternative for a broad range of substrates.",B,MAC_Bench/ACS/Cover/ACS Sustainable Chemistry & Engineering/2024_13.png,MAC_Bench/ACS/Cover/ACS Sustainable Chemistry & Engineering/2024_13.png,clip,2024_13.txt,MAC_Bench/ACS/Cover/ACS Sustainable Chemistry & Engineering/2025_5.png,MAC_Bench/ACS/Cover/ACS Sustainable Chemistry & Engineering/2025_5.png,groundtruth,2025_5.txt,MAC_Bench/ACS/Cover/ACS Sustainable Chemistry & Engineering/2023_28.png,MAC_Bench/ACS/Cover/ACS Sustainable Chemistry & Engineering/2023_28.png,ave_2,2023_28.txt,MAC_Bench/ACS/Cover/ACS Sustainable Chemistry & Engineering/2024_26.png,MAC_Bench/ACS/Cover/ACS Sustainable Chemistry & Engineering/2024_26.png,vitg,2024_26.txt,train1104Biomacromolecules,2024_7,Which of the following options best describe the cover story?,"The cover art design incorporates three key elements: metal ions, bone defect tissue, and hydrogel. The layout comprises an upper and lower structure. The upper part showcases multiple molecular formulas of hydrogel components and metal ions, while the lower part depicts a bone defect tissue filled with a metal ion-containing hybrid hydrogel, featuring the release of multiple metal ions from the hybrid hydrogel between bone trabeculae. The overall background is a dark blue with elements resembling a starry sky, evoking a sense of technology, artistry, and professionalism, closely aligning with the theme of the paper.",D,MAC_Bench/ACS/Cover/Biomacromolecules/2020_5.png,MAC_Bench/ACS/Cover/Biomacromolecules/2020_5.png,vitg,2020_5.txt,MAC_Bench/ACS/Cover/Biomacromolecules/2024_6.png,MAC_Bench/ACS/Cover/Biomacromolecules/2024_6.png,clip,2024_6.txt,MAC_Bench/ACS/Cover/Biomacromolecules/2024_10.png,MAC_Bench/ACS/Cover/Biomacromolecules/2024_10.png,ave_3,2024_10.txt,MAC_Bench/ACS/Cover/Biomacromolecules/2024_7.png,MAC_Bench/ACS/Cover/Biomacromolecules/2024_7.png,groundtruth,2024_7.txt,train1105Science Robotics,9_96,Which of the following options best describe the cover story?,"ONLINE COVER Perception Through In-Hand Manipulation. Similar to how humans can perceive objects through sight and touch, Suresh et al. constructed a framework that uses data gathered from vision and touch to estimate an object’s pose and shape during manipulation. A dexterous multifingered hand equipped with vision-based touch sensors gathers tactile information while rotating an object. The tactile data, along with visual data from a stationary camera, are input into an online neural field that uses simultaneous localization and mapping to output the geometry of the object. The technique can reconstruct novel objects with high precision, even under heavy occlusion. This month’s cover is an image of a multifingered robot equipped with this framework to perceive the pose and shape of a wooden die. Credit: Sudharshan Suresh",B,MAC_Bench/Science/Cover/Science Robotics/8_84.png,MAC_Bench/Science/Cover/Science Robotics/8_84.png,clip,8_84.txt,MAC_Bench/Science/Cover/Science Robotics/9_96.png,MAC_Bench/Science/Cover/Science Robotics/9_96.png,groundtruth,9_96.txt,MAC_Bench/Science/Cover/Science Robotics/5_48.png,MAC_Bench/Science/Cover/Science Robotics/5_48.png,ave_2,5_48.txt,MAC_Bench/Science/Cover/Science Robotics/9_97.png,MAC_Bench/Science/Cover/Science Robotics/9_97.png,vitg,9_97.txt,val1106Immunity,57_9,Which of the following options best describe the cover story?,"On the cover: 2024 marks the 30th anniversary of Immunity! To celebrate this milestone with the immunology community, we hosted an open call1107for cover submissions for our special anniversary issue and are grateful to have received1108beautiful and creative submissions from across the globe! The winning design featured1109on the cover of this anniversary issue was designed by Yun Hsuan Elena Lin, a PhD1110candidate in the laboratory of Dr. John Chang at the University of Californa, San1111Diego. In her illustration, immune cells are depicted as flowers flourishing from1112vases in the shape of the number 30. The stalks of the flowers are comprised of DNA,1113RNA, mitochondria, antibodies, blood vessels, lymphatics, neuronal and glial cells,1114microbes, and more, highlighting advances in immunology research over the past decades.1115Model organisms populate the image as well, recognizing their key contributions in1116driving substantial advances in human immunology. The bouquet captures the diversity1117of immunological research published by Immunity, painted over a backdrop of dawn that symbolizes the exciting discoveries to come. In this issue, we present a collection of review and perspective articles on innate1118immunity with a focus on pattern recognition. Rather than recognizing unique aspects1119of a pathogen, the innate immune system uses families of receptors that recognize1120shared features of potential threats to the host. Likewise, sensing of endogenous1121molecular patterns enables maintenance of health. Throughout this collection of articles,1122we explore the latest understanding of how the innate immune system evolved to ensure1123that the body responds appropriately to the myriad of microbes in the environment1124while maintaining regulation of homeostatic functions, how these mechanisms can go1125awry in disease, and the prospects for harnessing these insights into the development1126of new therapies.",D,MAC_Bench/Cell/Cover/Immunity/57_11.png,MAC_Bench/Cell/Cover/Immunity/57_11.png,ave_2,57_11.txt,MAC_Bench/Cell/Cover/Immunity/57_6.png,MAC_Bench/Cell/Cover/Immunity/57_6.png,clip,57_6.txt,MAC_Bench/Cell/Cover/Immunity/54_5.png,MAC_Bench/Cell/Cover/Immunity/54_5.png,ave_3,54_5.txt,MAC_Bench/Cell/Cover/Immunity/57_9.png,MAC_Bench/Cell/Cover/Immunity/57_9.png,groundtruth,57_9.txt,train1127Cell Genomics,4_5,Which of the following options best describe the cover story?,"On the cover: One of the X chromosomes in females is inactivated through X chromosome1128inactivation (XCI). However, several X-linked genes escape from XCI and contribute1129to female-biased gene expression. In this issue of Cell Genomics, Tomofuji et al. develop scLinaX, a new bioinformatics tool to quantify the escape from XCI and elucidate1130the sex differences of gene regulation. The cover art depicts leaky lights from the1131inactivated X chromosome that represent the escape from XCI. Crafted by Anna Tsukasaki,1132this image visually captures the essence of the scLinaX method.",D,MAC_Bench/Cell/Cover/Cell Genomics/4_7.png,MAC_Bench/Cell/Cover/Cell Genomics/4_7.png,ave_1,4_7.txt,MAC_Bench/Cell/Cover/Cell Genomics/4_12.png,MAC_Bench/Cell/Cover/Cell Genomics/4_12.png,clip,4_12.txt,MAC_Bench/Cell/Cover/Cell Genomics/3_3.png,MAC_Bench/Cell/Cover/Cell Genomics/3_3.png,vith,3_3.txt,MAC_Bench/Cell/Cover/Cell Genomics/4_5.png,MAC_Bench/Cell/Cover/Cell Genomics/4_5.png,groundtruth,4_5.txt,train1133Industrial & Engineering Chemistry Research,2024_42,Which of the following options best describe the cover story?,"Lemon juice, a readily available and biodegradable natural substance, was used to prepare carbon dots (CDs) in one step by a microflow approach. The derived CDs",D,MAC_Bench/ACS/Cover/Industrial & Engineering Chemistry Research/2020_32.png,MAC_Bench/ACS/Cover/Industrial & Engineering Chemistry Research/2020_32.png,vitg,2020_32.txt,MAC_Bench/ACS/Cover/Industrial & Engineering Chemistry Research/2018_42.png,MAC_Bench/ACS/Cover/Industrial & Engineering Chemistry Research/2018_42.png,vith,2018_42.txt,MAC_Bench/ACS/Cover/Industrial & Engineering Chemistry Research/2024_45.png,MAC_Bench/ACS/Cover/Industrial & Engineering Chemistry Research/2024_45.png,clip,2024_45.txt,MAC_Bench/ACS/Cover/Industrial & Engineering Chemistry Research/2024_42.png,MAC_Bench/ACS/Cover/Industrial & Engineering Chemistry Research/2024_42.png,groundtruth,2024_42.txt,train1134ACS Chemical Biology,2024_7,Which of the following options best describe the cover story?,"Measuring the cell penetration of biotherapeutics is challenging. New techniques are revealing precisely how much of a peptide or oligonucleotide drug penetrates to the cytosol or nucleus of target cells. Excitingly, these techniques are now being used to reveal differential penetration into different cell types, allowing drug developers to better understand how these drugs get into cells and what governs their cell-type selectivity. Cover art was generated with the assistance of Canva Magic Studio and Adobe Photoshop.",B,MAC_Bench/ACS/Cover/ACS Chemical Biology/2022_8.png,MAC_Bench/ACS/Cover/ACS Chemical Biology/2022_8.png,clip,2022_8.txt,MAC_Bench/ACS/Cover/ACS Chemical Biology/2024_7.png,MAC_Bench/ACS/Cover/ACS Chemical Biology/2024_7.png,groundtruth,2024_7.txt,MAC_Bench/ACS/Cover/ACS Chemical Biology/2022_7.png,MAC_Bench/ACS/Cover/ACS Chemical Biology/2022_7.png,vith,2022_7.txt,MAC_Bench/ACS/Cover/ACS Chemical Biology/2021_2.png,MAC_Bench/ACS/Cover/ACS Chemical Biology/2021_2.png,ave_2,2021_2.txt,train1135NATURE REVIEWS DRUG DISCOVERY,23_12,Which of the following options best describe the cover story?,"The art of therapeutic mRNA design, inspired by the Review on p67.1136Cover design: S. Harris",A,MAC_Bench/Nature/Cover/NATURE REVIEWS DRUG DISCOVERY/23_12.png,MAC_Bench/Nature/Cover/NATURE REVIEWS DRUG DISCOVERY/23_12.png,groundtruth,23_12.txt,MAC_Bench/Nature/Cover/NATURE REVIEWS DRUG DISCOVERY/24_2.png,MAC_Bench/Nature/Cover/NATURE REVIEWS DRUG DISCOVERY/24_2.png,clip,24_2.txt,MAC_Bench/Nature/Cover/NATURE REVIEWS DRUG DISCOVERY/24_1.png,MAC_Bench/Nature/Cover/NATURE REVIEWS DRUG DISCOVERY/24_1.png,ave_2,24_1.txt,MAC_Bench/Nature/Cover/NATURE REVIEWS DRUG DISCOVERY/23_9.png,MAC_Bench/Nature/Cover/NATURE REVIEWS DRUG DISCOVERY/23_9.png,ave_3,23_9.txt,train1137One Earth,7_2,Which of the following options best describe the cover story?,"On the cover: The Brazilian Amazon Açaí berry, which contains antioxidant, hypolipidemic,1138and anti-inflammatory properties, has boosted local economies within the Brazilian1139Amazon. This image captures baskets filled with Açaí placed at Feira do Açaí (Açaí1140Market), a public trading open-air market specifically for Açaí, on the Ver-o-Peso1141in Belé, the capital of Pará state in the Amazon region in the north of Brazil. Getty,1142Paulo Amorim.",B,MAC_Bench/Cell/Cover/One Earth/5_8.png,MAC_Bench/Cell/Cover/One Earth/5_8.png,vith,5_8.txt,MAC_Bench/Cell/Cover/One Earth/7_2.png,MAC_Bench/Cell/Cover/One Earth/7_2.png,groundtruth,7_2.txt,MAC_Bench/Cell/Cover/One Earth/1_1.png,MAC_Bench/Cell/Cover/One Earth/1_1.png,ave_2,1_1.txt,MAC_Bench/Cell/Cover/One Earth/7_3.png,MAC_Bench/Cell/Cover/One Earth/7_3.png,clip,7_3.txt,train1143Nature Reviews Clinical Oncology,21_2,Which of the following options best describe the cover story?,"The road travelled and challenges ahead in clinical oncology, inspired by the Viewpoint on p771.1144Cover design: Carl Conway",B,MAC_Bench/Nature/Cover/Nature Reviews Clinical Oncology/21_3.png,MAC_Bench/Nature/Cover/Nature Reviews Clinical Oncology/21_3.png,clip,21_3.txt,MAC_Bench/Nature/Cover/Nature Reviews Clinical Oncology/21_2.png,MAC_Bench/Nature/Cover/Nature Reviews Clinical Oncology/21_2.png,groundtruth,21_2.txt,MAC_Bench/Nature/Cover/Nature Reviews Clinical Oncology/21_4.png,MAC_Bench/Nature/Cover/Nature Reviews Clinical Oncology/21_4.png,ave_1,21_4.txt,MAC_Bench/Nature/Cover/Nature Reviews Clinical Oncology/21_1.png,MAC_Bench/Nature/Cover/Nature Reviews Clinical Oncology/21_1.png,vitg,21_1.txt,val1145Trends in Cognitive Sciences,28_7,Which of the following options best describe the cover story?,"In this issue of Trends in Cognitive Sciences, Shaun Gallagher and1146colleagues propose a ‘pattern theory of compassion’ that clarifies distinctions between1147empathy, sympathy, and compassion. The pattern theory identifies a set of diverse1148components that form a dynamic Gestalt constitutive of compassion. A review of1149neuroscientific studies of compassion provides evidence to support the pattern theory,1150and the processes and factors that make up the pattern can contribute to guide1151compassion training. The anthropomorphic cartoon on the cover depicts some of the1152differences between empathy, sympathy, and compassion. From left to right: empathy1153(quasi-isomorphic) is signified by the quasi-same color for empathizer-empathized;1154sympathy (related but not isomorphic) is signified by similar band colors; compassion1155(non-isomorphic) is signified by different colors. Image by Junio Aglioti Colombini.",D,MAC_Bench/Cell/Cover/Trends in Cognitive Sciences/21_5.png,MAC_Bench/Cell/Cover/Trends in Cognitive Sciences/21_5.png,clip,21_5.txt,MAC_Bench/Cell/Cover/Trends in Cognitive Sciences/25_10.png,MAC_Bench/Cell/Cover/Trends in Cognitive Sciences/25_10.png,ave_2,25_10.txt,MAC_Bench/Cell/Cover/Trends in Cognitive Sciences/27_3.png,MAC_Bench/Cell/Cover/Trends in Cognitive Sciences/27_3.png,vitg,27_3.txt,MAC_Bench/Cell/Cover/Trends in Cognitive Sciences/28_7.png,MAC_Bench/Cell/Cover/Trends in Cognitive Sciences/28_7.png,groundtruth,28_7.txt,test1156Nature Sustainability,7_4,Which of the following options best describe the cover story?,"Sustainable microfabrication1157Microfabrication has a crucial role in device fabrication but has an unfavourable environmental footprint. Yang and colleagues present a bioinspired permeable junction approach for sustainable microfabrication, using no hazardous chemicals and substantially reduced energy consumption.1158See Yang et al.1159Image: Bozhi Tian, University of Chicago. Cover design: Alex Whitworth",A,MAC_Bench/Nature/Cover/Nature Sustainability/7_4.png,MAC_Bench/Nature/Cover/Nature Sustainability/7_4.png,groundtruth,7_4.txt,MAC_Bench/Nature/Cover/Nature Sustainability/5_7.png,MAC_Bench/Nature/Cover/Nature Sustainability/5_7.png,ave_3,5_7.txt,MAC_Bench/Nature/Cover/Nature Sustainability/4_8.png,MAC_Bench/Nature/Cover/Nature Sustainability/4_8.png,clip,4_8.txt,MAC_Bench/Nature/Cover/Nature Sustainability/4_5.png,MAC_Bench/Nature/Cover/Nature Sustainability/4_5.png,vitg,4_5.txt,train1160Trends in Biochemical Sciences,49_9,Which of the following options best describe the cover story?,"The ancient oxytocin/vasopressin (OT/VP) signaling system has garnered1161significant attention for its broad implications to health and disease. Particularly1162within the central nervous system, its role in modulating social behavior presents1163a1164compelling avenue for exploration. On pages 361–377 in this issue, Perisic et al. offer a1165comprehensive review of OT-VP signaling system encompassing recent advancements1166and enduring obstacles. Their analysis sheds a light on the evolving landscape of1167this1168protein family, offering valuable insights into future directions for research. Cover1169image1170by Monika Perisic.",D,MAC_Bench/Cell/Cover/Trends in Biochemical Sciences/48_9.png,MAC_Bench/Cell/Cover/Trends in Biochemical Sciences/48_9.png,clip,48_9.txt,MAC_Bench/Cell/Cover/Trends in Biochemical Sciences/48_4.png,MAC_Bench/Cell/Cover/Trends in Biochemical Sciences/48_4.png,vitg,48_4.txt,MAC_Bench/Cell/Cover/Trends in Biochemical Sciences/49_11.png,MAC_Bench/Cell/Cover/Trends in Biochemical Sciences/49_11.png,ave_1,49_11.txt,MAC_Bench/Cell/Cover/Trends in Biochemical Sciences/49_9.png,MAC_Bench/Cell/Cover/Trends in Biochemical Sciences/49_9.png,groundtruth,49_9.txt,train1171Trends in Parasitology,40_6,Which of the following options best describe the cover story?,"Microscopy image analysis is critical in parasitology research because1172it allows researchers to analyze parasite shape, function, and life cycles. Traditional1173artificial intelligence (AI) methods often have limitations due to their black-box1174nature1175and lack of integration with human expert knowledge, which impedes their explainability1176and performance. In this issue of Trends in Parasitology, Feng et al. review the recent1177advancements in knowledge-integrated AI models for the analysis of parasite microscopy1178images. By incorporating expert knowledge from parasitologists into AI, the resulting1179knowledge-integrated models can offer both high accuracy and explainability. This1180synergy is especially important in parasitology, where the correct identification1181of parasites1182is crucial for the treatment and control of the disease. The cover image represents1183the1184partnership between AI and parasitologists, demonstrating how this paradigm leads1185to1186better diagnostics and research in parasitology. Image credit: Sen Li.",D,MAC_Bench/Cell/Cover/Trends in Parasitology/32_1.png,MAC_Bench/Cell/Cover/Trends in Parasitology/32_1.png,clip,32_1.txt,MAC_Bench/Cell/Cover/Trends in Parasitology/37_6.png,MAC_Bench/Cell/Cover/Trends in Parasitology/37_6.png,vitg,37_6.txt,MAC_Bench/Cell/Cover/Trends in Parasitology/40_3.png,MAC_Bench/Cell/Cover/Trends in Parasitology/40_3.png,vith,40_3.txt,MAC_Bench/Cell/Cover/Trends in Parasitology/40_6.png,MAC_Bench/Cell/Cover/Trends in Parasitology/40_6.png,groundtruth,40_6.txt,train1187Crystal Growth & Design,2024_20,Which of the following options best describe the cover story?,"The patterns on the conveyor belt on the cover represent the four ALD growth schemes mentioned in the text, namely, ""The one step ALD method for growing TMD films"", ""PE-ALD growth of TMD films"", ""ALD selective growth patterns"", and ""The two-step ALD method for growing TMD films"".",A,MAC_Bench/ACS/Cover/Crystal Growth & Design/2024_20.png,MAC_Bench/ACS/Cover/Crystal Growth & Design/2024_20.png,groundtruth,2024_20.txt,MAC_Bench/ACS/Cover/Crystal Growth & Design/2024_7.png,MAC_Bench/ACS/Cover/Crystal Growth & Design/2024_7.png,clip,2024_7.txt,MAC_Bench/ACS/Cover/Crystal Growth & Design/2024_10.png,MAC_Bench/ACS/Cover/Crystal Growth & Design/2024_10.png,ave_2,2024_10.txt,MAC_Bench/ACS/Cover/Crystal Growth & Design/2023_4.png,MAC_Bench/ACS/Cover/Crystal Growth & Design/2023_4.png,vith,2023_4.txt,val1188Nature Cardiovascular Research,3_7,Which of the following options best describe the cover story?,"Explaining heart failure1189Fernandez-Patron et al. propose a unifying framework explaining how diverse risk factors such as hypertension, obesity and diabetes lead to the pathogenesis and progression of heart failure.1190See Fernandez-Patron et al.1191Image: Eugenio Hardy, Center for Molecular Immunology, Cuba and Carlos Fernandez-Patron, University of Alberta, Canada. Cover design: Bethany Vukomanovic",D,MAC_Bench/Nature/Cover/Nature Cardiovascular Research/2_4.png,MAC_Bench/Nature/Cover/Nature Cardiovascular Research/2_4.png,clip,2_4.txt,MAC_Bench/Nature/Cover/Nature Cardiovascular Research/1_12.png,MAC_Bench/Nature/Cover/Nature Cardiovascular Research/1_12.png,vith,1_12.txt,MAC_Bench/Nature/Cover/Nature Cardiovascular Research/3_4.png,MAC_Bench/Nature/Cover/Nature Cardiovascular Research/3_4.png,vitg,3_4.txt,MAC_Bench/Nature/Cover/Nature Cardiovascular Research/3_7.png,MAC_Bench/Nature/Cover/Nature Cardiovascular Research/3_7.png,groundtruth,3_7.txt,train1192Nature Cardiovascular Research,3_3,Which of the following options best describe the cover story?,"Endotheliitis and cardiac dysfunction in long COVID1193Thomas et al. use thrombotic vascular tissues and induced pluripotent stem cell-derived cardiac organoids to show that COVID-19-induced vascular endotheliitis and cytokine release disrupt endothelial–cardiomyocyte crosstalk and contribute to cardiac dysfunction in long COVID.1194See Thomas et al.1195Image: Christina Wu, freelance illustrator. Cover design: Bethany Vukomanovic",D,MAC_Bench/Nature/Cover/Nature Cardiovascular Research/1_12.png,MAC_Bench/Nature/Cover/Nature Cardiovascular Research/1_12.png,vitg,1_12.txt,MAC_Bench/Nature/Cover/Nature Cardiovascular Research/2_4.png,MAC_Bench/Nature/Cover/Nature Cardiovascular Research/2_4.png,ave_3,2_4.txt,MAC_Bench/Nature/Cover/Nature Cardiovascular Research/2_12.png,MAC_Bench/Nature/Cover/Nature Cardiovascular Research/2_12.png,clip,2_12.txt,MAC_Bench/Nature/Cover/Nature Cardiovascular Research/3_3.png,MAC_Bench/Nature/Cover/Nature Cardiovascular Research/3_3.png,groundtruth,3_3.txt,train1196Journal of the American Chemical Society,2024_34,Which of the following options best describe the cover story?,Tuning acid/base electrochemistry via hydrophobicity and electric fields. View the article.,A,MAC_Bench/ACS/Cover/Journal of the American Chemical Society/2024_34.png,MAC_Bench/ACS/Cover/Journal of the American Chemical Society/2024_34.png,groundtruth,2024_34.txt,MAC_Bench/ACS/Cover/Journal of the American Chemical Society/2022_30.png,MAC_Bench/ACS/Cover/Journal of the American Chemical Society/2022_30.png,vitg,2022_30.txt,MAC_Bench/ACS/Cover/Journal of the American Chemical Society/2018_38.png,MAC_Bench/ACS/Cover/Journal of the American Chemical Society/2018_38.png,vith,2018_38.txt,MAC_Bench/ACS/Cover/Journal of the American Chemical Society/2024_15.png,MAC_Bench/ACS/Cover/Journal of the American Chemical Society/2024_15.png,clip,2024_15.txt,train1197Industrial & Engineering Chemistry Research,2024_7,Which of the following options best describe the cover story?,"An overview of chemical reactions activated by plasma, including oxidation, reduction, copolymerization and polymerization, elimination, addition, isomerization, and rearrangement reactions.",D,MAC_Bench/ACS/Cover/Industrial & Engineering Chemistry Research/2024_14.png,MAC_Bench/ACS/Cover/Industrial & Engineering Chemistry Research/2024_14.png,vitg,2024_14.txt,MAC_Bench/ACS/Cover/Industrial & Engineering Chemistry Research/2022_49.png,MAC_Bench/ACS/Cover/Industrial & Engineering Chemistry Research/2022_49.png,clip,2022_49.txt,MAC_Bench/ACS/Cover/Industrial & Engineering Chemistry Research/2024_50.png,MAC_Bench/ACS/Cover/Industrial & Engineering Chemistry Research/2024_50.png,vith,2024_50.txt,MAC_Bench/ACS/Cover/Industrial & Engineering Chemistry Research/2024_7.png,MAC_Bench/ACS/Cover/Industrial & Engineering Chemistry Research/2024_7.png,groundtruth,2024_7.txt,val1198ACS Applied Optical Materials,2024_9,Which of the following options best describe the cover story?,"A multishell nanoparticle comprised of an ultrabright perovskite core and a nitric oxide sensitive orange-fluorescent emitting dye facilitating real-time imaging and ratiometric biosensing, especially in deep tissue.",B,MAC_Bench/ACS/Cover/ACS Applied Optical Materials/2023_2.png,MAC_Bench/ACS/Cover/ACS Applied Optical Materials/2023_2.png,clip,2023_2.txt,MAC_Bench/ACS/Cover/ACS Applied Optical Materials/2024_9.png,MAC_Bench/ACS/Cover/ACS Applied Optical Materials/2024_9.png,groundtruth,2024_9.txt,MAC_Bench/ACS/Cover/ACS Applied Optical Materials/2023_1.png,MAC_Bench/ACS/Cover/ACS Applied Optical Materials/2023_1.png,vitg,2023_1.txt,MAC_Bench/ACS/Cover/ACS Applied Optical Materials/2024_6.png,MAC_Bench/ACS/Cover/ACS Applied Optical Materials/2024_6.png,ave_3,2024_6.txt,train1199Crystal Growth & Design,2024_2,Which of the following options best describe the cover story?,"For the first time a N,N-chelating ligand, bis(4-iodopyrazol-1-yl)methane is explored as a halogen bond donor in piano-stool half-sandwich noble metal complexes.",D,MAC_Bench/ACS/Cover/Crystal Growth & Design/2018_1.png,MAC_Bench/ACS/Cover/Crystal Growth & Design/2018_1.png,vitg,2018_1.txt,MAC_Bench/ACS/Cover/Crystal Growth & Design/2024_1.png,MAC_Bench/ACS/Cover/Crystal Growth & Design/2024_1.png,clip,2024_1.txt,MAC_Bench/ACS/Cover/Crystal Growth & Design/2023_9.png,MAC_Bench/ACS/Cover/Crystal Growth & Design/2023_9.png,ave_3,2023_9.txt,MAC_Bench/ACS/Cover/Crystal Growth & Design/2024_2.png,MAC_Bench/ACS/Cover/Crystal Growth & Design/2024_2.png,groundtruth,2024_2.txt,train1200Cell Reports Physical Science,5_7,Which of the following options best describe the cover story?,"On the cover: In this issue, Ng et al. demonstrate a self-driving digital twin that is designed to automatically improve