NLP-FBK/English_Relation_Extraction_Task

1[2    {3        "text_id": "100376",4        "sentence_id": 1,5        "text": "We report a case of a male near-term neonate with gestational age of 35 weeks.",6        "relations": []7    },8    {9        "text_id": "100376",10        "sentence_id": 2,11        "text": "He was the third born child to a 27-year-old mother with no significant past history.",12        "relations": []13    },14    {15        "text_id": "100376",16        "sentence_id": 3,17        "text": "He was derived from a third degree consanguineous marriage.",18        "relations": []19    },20    {21        "text_id": "100376",22        "sentence_id": 4,23        "text": "He was born by means of normal vaginal delivery with a normal extra-uterine adaptation.",24        "relations": []25    },26    {27        "text_id": "100376",28        "sentence_id": 5,29        "text": "Meconium-stained amniotic fluid was noted.",30        "relations": []31    },32    {33        "text_id": "100376",34        "sentence_id": 6,35        "text": "His birth weight was 3030g (75 th Percentile).",36        "relations": [37            [38                "3030g",39                "weight"40            ]41        ]42    },43    {44        "text_id": "100376",45        "sentence_id": 7,46        "text": "The baby had normal physical examination at birth aside transitory respiratory distress.",47        "relations": []48    },49    {50        "text_id": "100376",51        "sentence_id": 8,52        "text": "He had been hospitalized for four days in a private clinic, for the suspicion of materno-foetal infection, where he had antibiotics for 48 hours.",53        "relations": []54    },55    {56        "text_id": "100376",57        "sentence_id": 9,58        "text": "He had developed no symptoms during his hospitalization.",59        "relations": []60    },61    {62        "text_id": "100376",63        "sentence_id": 10,64        "text": "The output's weight was 2400g which signify the loss of 630g.",65        "relations": [66            [67                "2400g",68                "weight"69            ]70        ]71    },72    {73        "text_id": "100376",74        "sentence_id": 11,75        "text": "Back home, he received exclusive maternal breastfeeding.",76        "relations": []77    },78    {79        "text_id": "100376",80        "sentence_id": 12,81        "text": "On his fifth day of life, he presented multiple yellowish-watery stools (ab 12 times) and refuse feeding with apyrexia context.",82        "relations": []83    },84    {85        "text_id": "100376",86        "sentence_id": 13,87        "text": "He had clinical signs of severe dehydration without fever or vomiting.",88        "relations": []89    },90    {91        "text_id": "100376",92        "sentence_id": 14,93        "text": "He lost 930g relative to the birth's weight.",94        "relations": []95    },96    {97        "text_id": "100376",98        "sentence_id": 15,99        "text": "The abdomen appeared neither tender nor distended, and the rest of his physical examination was normal.",100        "relations": [101            [102                "normal",103                "examination"104            ]105        ]106    },107    {108        "text_id": "100376",109        "sentence_id": 16,110        "text": "The laboratory findings revealed hypernatremia of 152mEq/L, hyperkalemia of 7,8mEq/L and severe metabolic acidosis: blood PH: 7,1, HCO3:4mEq/L.",111        "relations": [112            [113                "152mEq/L",114                "hypernatremia"115            ],116            [117                "7,8mEq/L",118                "hyperkalemia"119            ],120            [121                "7,1",122                "PH"123            ],124            [125                "4mEq/L",126                "HCO3"127            ]128        ]129    },130    {131        "text_id": "100376",132        "sentence_id": 17,133        "text": "The osmotic gap was 45.",134        "relations": [135            [136                "45",137                "gap"138            ]139        ]140    },141    {142        "text_id": "100376",143        "sentence_id": 18,144        "text": "There was no leukocytosis, and the serum level of C-reactive protein was normal.",145        "relations": [146            [147                "normal",148                "level"149            ]150        ]151    },152    {153        "text_id": "100376",154        "sentence_id": 19,155        "text": "The infant was treated with intravenous fluids and electrolytes as well as antibiotics after obtaining blood and stool cultures, assuming an infectious etiology.",156        "relations": []157    },158    {159        "text_id": "100376",160        "sentence_id": 20,161        "text": "After 26 hours of rehydration therapy, the dehydration resolved, however, a functional acute renal failure complicated by acidosis and hyperkalemia appeared.",162        "relations": []163    },164    {165        "text_id": "100376",166        "sentence_id": 21,167        "text": "The chest radiograph showed \"bat wings\" pattern and the cardiothoracic index was 0, 45.",168        "relations": [169            [170                "0, 45",171                "index"172            ]173        ]174    },175    {176        "text_id": "100376",177        "sentence_id": 22,178        "text": "The renal ultrasound showed discretely hyperechoic kidneys cortex and the absence of renal malformations.",179        "relations": []180    },181    {182        "text_id": "100376",183        "sentence_id": 23,184        "text": "On the 11 th day of life, he was transferred to the pediatric intensive care unit.",185        "relations": []186    },187    {188        "text_id": "100376",189        "sentence_id": 24,190        "text": "He needed mechanical ventilation for three days and exclusive parenteral feeding by central catheter.",191        "relations": []192    },193    {194        "text_id": "100376",195        "sentence_id": 25,196        "text": "The evolution was burdened by cholestasis due to the prolonged parenteral feeding and nosocomial infection by staphylococcus epidermidis.",197        "relations": []198    },199    {200        "text_id": "100376",201        "sentence_id": 26,202        "text": "Since his admission, he had developed a slimy diarrhea with 3 to 4 stools per day.",203        "relations": []204    },205    {206        "text_id": "100376",207        "sentence_id": 27,208        "text": "He presented a profuse diarrhea during each attempt to introduce enteral feeding by hydrolyzed milk formula.",209        "relations": []210    },211    {212        "text_id": "100376",213        "sentence_id": 28,214        "text": "He was discharged after 32 days with output's weight 3250g.",215        "relations": [216            [217                "3250g",218                "weight"219            ]220        ]221    },222    {223        "text_id": "100376",224        "sentence_id": 29,225        "text": "The oesophago-gastro-duodenoscopy and duodenal biopsy showed partial villous atrophy associated to the brush border abnormalities.",226        "relations": []227    },228    {229        "text_id": "100376",230        "sentence_id": 30,231        "text": "The periodic acid Schiff (PAS) stain revealed abnormalities in the brush border characterized by loss of the linear part of enterocytes with the presence of intra-cytoplasmic PAS + band in the apical pole of enterocytes uneven thickness and sometimes with double contours pattern.",232        "relations": []233    },234    {235        "text_id": "100376",236        "sentence_id": 31,237        "text": "In the submucosa, there were numerous Brunner glands.",238        "relations": []239    },240    {241        "text_id": "100376",242        "sentence_id": 32,243        "text": "We find the existence of numerous hemorrhagic suffusions.",244        "relations": [245            [246                "positive",247                "immunostain"248            ]249        ]250    },251    {252        "text_id": "100376",253        "sentence_id": 33,254        "text": "The CD10 immunostain was positive.",255        "relations": []256    },257    {258        "text_id": "100376",259        "sentence_id": 34,260        "text": "Thus, a diagnosis hypothesis of MVID was raised.",261        "relations": []262    },263    {264        "text_id": "100376",265        "sentence_id": 35,266        "text": "The electron microscopic examination confirmed the diagnosis.",267        "relations": []268    },269    {270        "text_id": "100376",271        "sentence_id": 36,272        "text": "Mutation analysis of peripheral blood samples of the neonate revealed a mutation at the homozygous status of MYO5B gene.",273        "relations": []274    },275    {276        "text_id": "100376",277        "sentence_id": 37,278        "text": "The baby died, after 97 days of life, of septic shock and multiple organ failure.",279        "relations": []280    },281    {282        "text_id": "100506",283        "sentence_id": 1,284        "text": "The patient was a 35-year old female who presented with urinary frequency for 2 months.",285        "relations": []286    },287    {288        "text_id": "100506",289        "sentence_id": 2,290        "text": "Her past medical history showed a nonsmoking history and no significant family history.",291        "relations": []292    },293    {294        "text_id": "100506",295        "sentence_id": 3,296        "text": "The physical examination was unremarkable.",297        "relations": []298    },299    {300        "text_id": "100506",301        "sentence_id": 4,302        "text": "She was treated as urinary tract infection, but there was no improvement in her symptoms.",303        "relations": []304    },305    {306        "text_id": "100506",307        "sentence_id": 5,308        "text": "Urine analysis and culture were performed several times that was negative for infection.",309        "relations": [310            [311                "negative",312                "infection"313            ]314        ]315    },316    {317        "text_id": "100506",318        "sentence_id": 6,319        "text": "Other laboratory data were also insignificant.",320        "relations": []321    },322    {323        "text_id": "100506",324        "sentence_id": 7,325        "text": "Through a routine evaluation, urinary system ultrasonography (US) revealed a bladder lesion measuring 7 mm.",326        "relations": [327            [328                "7 mm",329                "measuring"330            ]331        ]332    },333    {334        "text_id": "100506",335        "sentence_id": 8,336        "text": "In order to confirm the diagnosis, magnetic resonance imaging (MRI) of the abdomen and pelvic cavity was done; it revealed a lesion in the dome of the bladder.",337        "relations": []338    },339    {340        "text_id": "100506",341        "sentence_id": 9,342        "text": "To confirm the diagnosis and for histopathological examination, the patient underwent Transurethral Resection of Bladder Tumor (TURBT) in April 2018.",343        "relations": []344    },345    {346        "text_id": "100506",347        "sentence_id": 10,348        "text": "Before starting the procedure, the urethra was dilated till Fr: 28; at first, the tumor location was specified by cystoscopy.",349        "relations": []350    },351    {352        "text_id": "100506",353        "sentence_id": 11,354        "text": "Then, it was resected by monopolar cautery from superficial to deeper parts with removal of the muscle layers.",355        "relations": []356    },357    {358        "text_id": "100506",359        "sentence_id": 12,360        "text": "Proper bleeders were taken and three way Foley catheter was applied for a continuous irrigation.",361        "relations": []362    },363    {364        "text_id": "100506",365        "sentence_id": 13,366        "text": "The patient was transferred to the recovery room with complete stability.",367        "relations": []368    },369    {370        "text_id": "100506",371        "sentence_id": 14,372        "text": "The histopathology slides show a well-defined mass composed of bland looking spindle cells.",373        "relations": []374    },375    {376        "text_id": "100506",377        "sentence_id": 15,378        "text": "Subsequent immunohistochemistry (IHC) was done which showed diffuse immunoreactivity for S100, but other markers including smooth muscle actin (SMA), desmin, cytokeratin, CD34 and beta catenin were negative.",379        "relations": [380            [381                "negative",382                "markers"383            ],384            [385                "negative",386                "actin"387            ],388            [389                "negative",390                "CD34"391            ],392            [393                "negative",394                "desmin"395            ],396            [397                "negative",398                "SMA"399            ],400            [401                "negative",402                "cytokeratin"403            ],404            [405                "negative",406                "catenin"407            ],408            [409                "2-3%",410                "Ki67"411            ]412        ]413    },414    {415        "text_id": "100506",416        "sentence_id": 16,417        "text": "Ki67 was 2-3%, so the diagnosis of schwannoma was confirmed.",418        "relations": []419    },420    {421        "text_id": "100506",422        "sentence_id": 17,423        "text": "Then, the neck, abdomen, pelvic and chest computed tomography (CT) scans were done that were normal.",424        "relations": [425            [426                "normal",427                "scans"428            ]429        ]430    },431    {432        "text_id": "100506",433        "sentence_id": 18,434        "text": "Brain and spine MRI and physical examination showed no evidence of other schwannoma or evidence of neurofibromatosis.",435        "relations": []436    },437    {438        "text_id": "100506",439        "sentence_id": 19,440        "text": "She had no history of neurofibromatosis in her family.",441        "relations": []442    },443    {444        "text_id": "100506",445        "sentence_id": 20,446        "text": "Skin examination was normal and had no café au lait spot.",447        "relations": [448            [449                "normal",450                "examination"451            ]452        ]453    },454    {455        "text_id": "100506",456        "sentence_id": 21,457        "text": "She was not a case of von Recklinghausen disease.",458        "relations": []459    },460    {461        "text_id": "100543",462        "sentence_id": 1,463        "text": "A 12-year-old girl presented an abdominal pain, high persistent fever of (40°C) and severe fatigue.",464        "relations": [465            [466                "40°C",467                "fever"468            ]469        ]470    },471    {472        "text_id": "100543",473        "sentence_id": 2,474        "text": "The physical exam revealed pallor, hepatomegaly, and grade III splenomegaly.",475        "relations": []476    },477    {478        "text_id": "100543",479        "sentence_id": 3,480        "text": "The investigation revealed an elevated white blood cell count (WBC): 545,000/mm³.",481        "relations": [482            [483                "545,000/mm³",484                "count"485            ],486            [487                "545,000/mm³",488                "WBC"489            ]490        ]491    },492    {493        "text_id": "100543",494        "sentence_id": 4,495        "text": "PNN: 49,050/mm³, hemoglobin: 11.6g/dl, platelets: 328,000/mm³.",496        "relations": [497            [498                "49,050/mm³",499                "PNN"500            ],501            [502                "11.6g/dl",503                "hemoglobin"504            ],505            [506                "328,000/mm³",507                "platelets"508            ]509        ]510    },511    {512        "text_id": "100543",513        "sentence_id": 5,514        "text": "The patient's peripheral blood smear revealed marked leukocytosis with a significant number of immature myeloid precursors and 21% blasts.",515        "relations": []516    },517    {518        "text_id": "100543",519        "sentence_id": 6,520        "text": "The analysis of the BCR-ABL shows 94% in the peripheral blood.",521        "relations": [522            [523                "94%",524                "BCR-ABL"525            ]526        ]527    },528    {529        "text_id": "100543",530        "sentence_id": 7,531        "text": "The patient was diagnosed with CML.",532        "relations": []533    },534    {535        "text_id": "100543",536        "sentence_id": 8,537        "text": "She received a chemotherapy protocol made of hyperalkalinisation, allopurinol, hydroxyurea and a treatment based on imatinib at the dose of 400mg per day.",538        "relations": []539    },540    {541        "text_id": "100543",542        "sentence_id": 9,543        "text": "Patient achieved complete hematological remission at three months and complete cytogenetic remission at 12 months.",544        "relations": []545    },546    {547        "text_id": "100543",548        "sentence_id": 10,549        "text": "The patient was readmitted into our pediatric department with complains of severe headache, vomiting, pain and bilateral visual loss since three days.",550        "relations": []551    },552    {553        "text_id": "100543",554        "sentence_id": 11,555        "text": "On examination, patient was afebrile and appeared pale.",556        "relations": []557    },558    {559        "text_id": "100543",560        "sentence_id": 12,561        "text": "Blood pressure was 100/60mm/hg and the heart rate 98 beat/minute.",562        "relations": [563            [564                "100/60mm/hg",565                "pressure"566            ],567            [568                "98 beat/minute",569                "rate"570            ]571        ]572    },573    {574        "text_id": "100543",575        "sentence_id": 13,576        "text": "There was no lymphadenopathy and the nervous system examination was normal.",577        "relations": [578            [579                "normal",580                "examination"581            ]582        ]583    },584    {585        "text_id": "100543",586        "sentence_id": 14,587        "text": "Intraocular muscle testing was normal; however, there was an exophthalmia in both eyes.",588        "relations": [589            [590                "normal",591                "testing"592            ]593        ]594    },595    {596        "text_id": "100543",597        "sentence_id": 15,598        "text": "The pupil was sluggish to react to light.",599        "relations": []600    },601    {602        "text_id": "100543",603        "sentence_id": 16,604        "text": "Fundoscopy revealed bilateral stade III disc edema and hemorrhages of the retina.",605        "relations": []606    },607    {608        "text_id": "100543",609        "sentence_id": 17,610        "text": "She underwent a brain computed tomography (CT) scan with the suspicion of leukemic involvement or any other intracranial event (cerebral edema); however, nothing was found.",611        "relations": []612    },613    {614        "text_id": "100543",615        "sentence_id": 18,616        "text": "A subsequent bone marrow exam showed no morphologic or molecular evidence of CML or acute leukemia.",617        "relations": []618    },619    {620        "text_id": "100543",621        "sentence_id": 19,622        "text": "Cytological evaluation of cerebrospinal fluid (CSF) was also negative.",623        "relations": [624            [625                "negative",626                "evaluation"627            ]628        ]629    },630    {631        "text_id": "100543",632        "sentence_id": 20,633        "text": "The patient had no other known pathology that could be held responsible for retina edema.",634        "relations": []635    },636    {637        "text_id": "100543",638        "sentence_id": 21,639        "text": "We suggested that it was a side effect of imatinib so its administration was temporary interrupted.",640        "relations": []641    },642    {643        "text_id": "100543",644        "sentence_id": 22,645        "text": "The patient was put on an anti-edema therapy (mannitol, dexamethasone).",646        "relations": []647    },648    {649        "text_id": "100543",650        "sentence_id": 23,651        "text": "However, few months later, the patient presented in the emergency room with a headache and severe vomiting.",652        "relations": []653    },654    {655        "text_id": "100543",656        "sentence_id": 24,657        "text": "She described a recurrence of the same character of headaches accompanied with weakness of extremities and seizures.",658        "relations": []659    },660    {661        "text_id": "100543",662        "sentence_id": 25,663        "text": "Nervous system examination revealed neck rigidity, presence of meningeal signs and lower limb paraplegia.",664        "relations": []665    },666    {667        "text_id": "100543",668        "sentence_id": 26,669        "text": "CT of the brain revealed subdural chronic hematoma and a serpenginous gyriform enhancement around the contusion in the right parietal and occipital lobes.",670        "relations": []671    },672    {673        "text_id": "100543",674        "sentence_id": 27,675        "text": "Analysis of the CSF collected showed lymphoblasts in a WBC count of 11000cells/ml.",676        "relations": [677            [678                "11000cells/ml",679                "lymphoblasts"680            ],681            [682                "11000cells/ml",683                "count"684            ]685        ]686    },687    {688        "text_id": "100543",689        "sentence_id": 28,690        "text": "Flow cytometry of the CSF showed that blast cells were positive for a cluster of differentiation markers (CD) (CD34, CD19, CD10, CD22 and partially positive for CD45) confirming CNS extramedullary lymphoid blast infiltration.",691        "relations": [692            [693                "positive",694                "markers"695            ],696            [697                "partially positive",698                "CD45"699            ]700        ]701    },702    {703        "text_id": "100543",704        "sentence_id": 29,705        "text": "A bone marrow aspiration was done to evaluate the status of her chronic myelogenous leukemia and result was consistent with a chronic phase.",706        "relations": []707    },708    {709        "text_id": "100543",710        "sentence_id": 30,711        "text": "Fundus examination showed bilateral optic atrophy.",712        "relations": []713    },714    {715        "text_id": "100543",716        "sentence_id": 31,717        "text": "The diagnosis of extramedullary isolated CNS blast crises (lymphoid type) was based on the presence of blasts in CSF (confirmed by flow cytometry).",718        "relations": []719    },720    {721        "text_id": "100543",722        "sentence_id": 32,723        "text": "The patient received a high-dose systemic induction chemotherapy and intrathecal therapy (methotrexate, arabinoside and dexamethasone).",724        "relations": []725    },726    {727        "text_id": "100543",728        "sentence_id": 33,729        "text": "The imatinib was replaced by dasatinib at the dose of 100 mg per day.",730        "relations": []731    },732    {733        "text_id": "100543",734        "sentence_id": 34,735        "text": "She was treated with 24 Gy of whole-brain radiation therapy.",736        "relations": []737    },738    {739        "text_id": "100543",740        "sentence_id": 35,741        "text": "Allogenic stem cell transplantation was not feasible.",742        "relations": []743    },744    {745        "text_id": "100543",746        "sentence_id": 36,747        "text": "We noticed a rapidly progressive amelioration in her neurological status after finishing systemic chemotherapy and physical therapy; however, the patient's visual loss showed no signs of improvement.",748        "relations": []749    },750    {751        "text_id": "108798",752        "sentence_id": 1,753        "text": "We report a case of a 63-year-old woman with a minute ampullary carcinoid tumor that was 7 mm in diameter, but was associated with 2 peripancreatic lymph node metastases.",754        "relations": [755            [756                "7 mm",757                "diameter"758            ]759        ]760    },761    {762        "text_id": "108798",763        "sentence_id": 2,764        "text": "Mild elevation of liver enzymes was found at her regular medical check-up.",765        "relations": []766    },767    {768        "text_id": "108798",769        "sentence_id": 3,770        "text": "Computed tomography (CT) revealed a markedly dilated common bile duct (CBD) and two enlarged peripancreatic lymph nodes.",771        "relations": []772    },773    {774        "text_id": "108798",775        "sentence_id": 4,776        "text": "Endoscopy showed that the ampulla was slightly enlarged by a submucosal tumor.",777        "relations": []778    },779    {780        "text_id": "108798",781        "sentence_id": 5,782        "text": "The biopsy specimen revealed tumor cells that showed monotonous proliferation suggestive of a carcinoid tumor.",783        "relations": []784    },785    {786        "text_id": "108798",787        "sentence_id": 6,788        "text": "She underwent a pylorus-preserving whipple resection with lymph node dissection.",789        "relations": []790    },791    {792        "text_id": "108798",793        "sentence_id": 7,794        "text": "The resected lesion was a small submucosal tumor (7 mm in diameter) at the ampulla, with metastasis to 2 peripancreatic lymph nodes, and it was diagnosed as a malignant carcinoid tumor.",795        "relations": [796            [797                "7 mm in diameter",798                "tumor"799            ]800        ]801    },802    {803        "text_id": "101318",804        "sentence_id": 1,805        "text": "We observed a 29 y.o. female proband with the episode of venous thrombosis at the age of 18 and family history of thrombosis.",806        "relations": []807    },808    {809        "text_id": "101318",810        "sentence_id": 2,811        "text": "The antithrombin level in our patient was low, 44-48% (AT deficiency type I).",812        "relations": [813            [814                "low",815                "level"816            ],817            [818                "44-48%",819                "level"820            ]821        ]822    },823    {824        "text_id": "101318",825        "sentence_id": 3,826        "text": "A new genetic variant c.662G > C (p.W221S) in the SERPINC1 gene was detected in proband and affected father but was absent in healthy sister.",827        "relations": []828    },829    {830        "text_id": "101318",831        "sentence_id": 4,832        "text": "We used in silico tools to evaluate the possible impact of p.W221S variant on protein structure and function.",833        "relations": []834    },835    {836        "text_id": "101318",837        "sentence_id": 5,838        "text": "In mutated SERPINC1 protein a new N-linked glycosylation site is formed, however, it is unclear if the glycosylation at 219-221 site is possible.",839        "relations": []840    }841]