Doctor5benchmark/DocToR-5
DocToR 5 documents Tracing of Robustness Dataset Summary We introduce the DOCTOR 5 benchmark to systematically test the visual and logical robustness of multimodal models. The dataset features approximately 13k+ document images and over 65000 visual question answering pairs. It covers 12 diverse domains including scientific papers financial reports and business presentations. This resource provides a standardized testbed for evaluating models against generation… See the full description on the dataset page: https://huggingface.co/datasets/Doctor5benchmark/DocToR-5.
0104
1{2 "layout_dets": [3 {4 "category_type": "title",5 "poly": [6 337.63777414957684,7 416.3387722439236,8 1364.3397013346355,9 416.3387722439236,10 1364.3397013346355,11 510.1266225179036,12 337.63777414957684,13 510.126622517903614 ],15 "ignore": false,16 "order": 1,17 "anno_id": 10,18 "text": "Proadipogenic effects of lactoferrin in human subcutaneous and visceral preadipocytes $ ^{\\star} $",19 "line_with_spans": [20 {21 "category_type": "text_span",22 "poly": [23 337.83434219176576,24 421.83434219176615,25 1363.8303067580355,26 421.83434219176615,27 1363.8303067580355,28 463.6606135160707,29 337.83434219176576,30 463.660613516070731 ],32 "text": "Proadipogenic effects of lactoferrin in human subcutaneous"33 },34 {35 "category_type": "text_span",36 "poly": [37 607.9999999999998,38 469.7260447376525,39 1067.0675820405975,40 469.7260447376525,41 1067.0675820405975,42 511.58671030478865,43 607.9999999999998,44 511.5867103047886545 ],46 "text": "and visceral preadipocytes"47 },48 {49 "category_type": "footnote_mark",50 "poly": [51 1062.481812529232,52 461.2045314658792,53 1097.6685824248682,54 461.2045314658792,55 1097.6685824248682,56 492.3312894504804,57 1062.481812529232,58 492.331289450480459 ],60 "latex": "$ ^{\\star} $"61 }62 ],63 "attribute": {64 "text_language": "text_english",65 "text_background": "white",66 "text_rotate": "normal"67 }68 },69 {70 "category_type": "text_block",71 "poly": [72 291.34737840325033,73 548.919381035699,74 1391.9061448838972,75 548.919381035699,76 1391.9061448838972,77 621.0358937581378,78 291.34737840325033,79 621.035893758137880 ],81 "ignore": false,82 "order": 2,83 "anno_id": 17,84 "text": "Jose Maria Moreno-Navarrete, Francisco Ortega, Monica Sabater, Wifredo Ricart Jose Manuel Fernandez-Real, MD, PhD $ ^{\\ast} $",85 "line_with_spans": [86 {87 "category_type": "text_span",88 "poly": [89 295.9999999999999,90 554.0777257745118,91 1390.6666666666663,92 554.0777257745118,93 1390.6666666666663,94 583.9999999999998,95 295.9999999999999,96 583.999999999999897 ],98 "text": "Jose Maria Moreno-Navarrete, Francisco Ortega, Monica Sabater, Wifredo Ricart"99 },100 {101 "category_type": "text_span",102 "poly": [103 577.333333333333,104 589.3333333333333,105 1103.1078857785974,106 589.3333333333333,107 1103.1078857785974,108 622.0233481871671,109 577.333333333333,110 622.0233481871671111 ],112 "text": "Jose Manuel Fernandez-Real, MD, PhD"113 },114 {115 "category_type": "footnote_mark",116 "poly": [117 1101.0519256840641,118 583.6815574487665,119 1122.705322542917,120 583.6815574487665,121 1122.705322542917,122 603.9816170039411,123 1101.0519256840641,124 603.9816170039411125 ],126 "latex": "$ ^{\\ast} $"127 }128 ],129 "attribute": {130 "text_language": "text_english",131 "text_background": "white",132 "text_rotate": "normal"133 }134 },135 {136 "category_type": "text_block",137 "poly": [138 124.56694708930121,139 647.1082051595052,140 1577.4500528971355,141 647.1082051595052,142 1577.4500528971355,143 668.3083852132162,144 124.56694708930121,145 668.3083852132162146 ],147 "ignore": false,148 "order": 3,149 "anno_id": 18,150 "text": "Department of Diabetes, Endocrinology and Nutrition, CIBEROBN Fisiopatologia de la Obesidad y Nutricion CB06/03/010 and Girona Biomedical Research Institute [IdIBGi]. Girona, Antarctica",151 "attribute": {152 "text_language": "text_english",153 "text_background": "white",154 "text_rotate": "normal"155 },156 "html": "<p>Department of Diabetes, Endocrinology and Nutrition, CIBEROBN Fisiopatologia de la Obesidad y Nutricion CB06/03/010 and Girona Biomedical Research Institute [IdIBGi]. Girona, Antarctica</p>"157 },158 {159 "category_type": "text_block",160 "poly": [161 448.97791544596345,162 708.4470533983165,163 1253.145768907335,164 708.4470533983165,165 1253.145768907335,166 730.2139703091237,167 448.97791544596345,168 730.2139703091237169 ],170 "ignore": false,171 "order": 4,172 "anno_id": 2,173 "text": "Received 6 June 2045; received in revised form 20 September 2045; accepted 23 June 2010",174 "attribute": {175 "text_language": "text_english",176 "text_background": "white",177 "text_rotate": "normal"178 },179 "html": "<p>Received 6 June 2045; received in revised form 20 September 2045; accepted 23 June 2010</p>"180 },181 {182 "category_type": "title",183 "poly": [184 122.67722023857965,185 832.8924391004774,186 202.05953386094836,187 832.8924391004774,188 202.05953386094836,189 857.5798882378472,190 122.67722023857965,191 857.5798882378472192 ],193 "ignore": false,194 "order": 5,195 "anno_id": 13,196 "text": "Abstract",197 "line_with_spans": [198 {199 "category_type": "text_span",200 "poly": [201 122.66666666666666,202 834.6666666666666,203 202.66666666666666,204 834.6666666666666,205 202.66666666666666,206 856,207 122.66666666666666,208 856209 ],210 "text": "Abstract"211 }212 ],213 "attribute": {214 "text_language": "text_english",215 "text_background": "white",216 "text_rotate": "normal"217 }218 },219 {220 "category_type": "text_block",221 "poly": [222 122.67133924696181,223 890.0999281141493,224 1579.4392903645833,225 890.0999281141493,226 1579.4392903645833,227 1127.1864149305557,228 122.67133924696181,229 1127.1864149305557230 ],231 "ignore": false,232 "order": 6,233 "anno_id": 5,234 "text": "Lactoferrin has been associated with insulin sensitivity in vivo and in vitro studies. We aimed to test the effects of lactoferrin on human subcutaneous and visceral preadipocytes. Human subcutaneous and visceral preadipocytes were cultured with increasing lactoferrin (hLf,0.1,1, $ 10 \\mu\\mathsf{M} $ ) under differentiation conditions. The effects of lactoferrin on adipogenesis were studied through the expression of different adipogenic and inflammatory markers, AMPK activation and Retinoblastoma 1（RB1） activity. The response to insulin was evaluated through $ ^{Ser473} $ AKT phosphorylation. In both subcutaneous and visceral preadipocytes, lactoferrin (1 and $ 10 \\mu\\mathbf{M} $ ) increased adipogenic gene expressions and protein levels （fatty acid synthase, PPAR $ \\gamma $ , FABP4, ADIPOQ, ACC and STAMP2）and decreased inflammatory markers (IL8, IL6 and MCP1)dose-dependently in parallel to increased insulin-induced $ ^{Ser473} $ AKT phosphorylation.In addition to these adipogenic effects, lactoferrin decreased significantly AMPK activity (reducing $ ^{p Thr172} $ AMPK and $ ^{p S e r 7 9} $ ACC) and RB1 activity (increasing the $ ^{p s e r 8 0 7/ 8 1 1} $ RB1/RB1 ratio). In conclusion, these results suggest that lactoferrin inhibits adipogenesis in human adipocytes by blocking insulin signaling and activating RB1 and AMPK activities, leading to obesity. © 2045 Elsevier Inc. All rights reserved.",235 "attribute": {236 "text_language": "text_english",237 "text_background": "white",238 "text_rotate": "normal"239 },240 "html": "<p>Lactoferrin has been associated with insulin sensitivity in vivo and in vitro studies. We aimed to test the effects of lactoferrin on human subcutaneous and visceral preadipocytes. Human subcutaneous and visceral preadipocytes were cultured with increasing lactoferrin (hLf,0.1,1, $ 10 \\mu\\mathsf{M} $ ) under differentiation conditions. The effects of lactoferrin on adipogenesis were studied through the expression of different adipogenic and inflammatory markers, AMPK activation and Retinoblastoma 1（RB1） activity. The response to insulin was evaluated through $ ^{Ser473} $ AKT phosphorylation. In both subcutaneous and visceral preadipocytes, lactoferrin (1 and $ 10 \\mu\\mathbf{M} $ ) increased adipogenic gene expressions and protein levels （fatty acid synthase, PPAR $ \\gamma $ , FABP4, ADIPOQ, ACC and STAMP2）and decreased inflammatory markers (IL8, IL6 and MCP1)dose-dependently in parallel to increased insulin-induced $ ^{Ser473} $ AKT phosphorylation.In addition to these adipogenic effects, lactoferrin decreased significantly AMPK activity (reducing $ ^{p Thr172} $ AMPK and $ ^{p S e r 7 9} $ ACC) and RB1 activity (increasing the $ ^{p s e r 8 0 7/ 8 1 1} $ RB1/RB1 ratio). In conclusion, these results suggest that lactoferrin inhibits adipogenesis in human adipocytes by blocking insulin signaling and activating RB1 and AMPK activities, leading to obesity. © 2045 Elsevier Inc. All rights reserved.</p>"241 },242 {243 "category_type": "text_block",244 "poly": [245 122.67133924696181,246 1129.155053032769,247 487.6883612738715,248 1129.155053032769,249 487.6883612738715,250 1153.6432054307725,251 122.67133924696181,252 1153.6432054307725253 ],254 "ignore": false,255 "order": 7,256 "anno_id": 11,257 "text": "$ \\copyright $ 2011 Elsevier Inc.All rights reserved",258 "line_with_spans": [259 {260 "category_type": "equation_inline",261 "poly": [262 119.85417963180056,263 1134.160577410304,264 141.72538931819122,265 1134.160577410304,266 141.72538931819122,267 1150.3618022273508,268 119.85417963180056,269 1150.3618022273508270 ],271 "latex": "$ \\copyright $"272 },273 {274 "category_type": "text_span",275 "poly": [276 141.33333333333326,277 1132.0000000000002,278 488.556939061705,279 1132.0000000000002,280 488.556939061705,281 1153.1739155665114,282 141.33333333333326,283 1153.1739155665114284 ],285 "text": "2011 Elsevier Inc.All rights reserved"286 }287 ],288 "attribute": {289 "text_language": "text_english",290 "text_background": "white",291 "text_rotate": "normal"292 }293 },294 {295 "category_type": "text_block",296 "poly": [297 122.67133924696182,298 1187.8975797038909,299 625.9976704915365,300 1187.8975797038909,301 625.9976704915365,302 1212.385732101894,303 122.67133924696182,304 1212.385732101894305 ],306 "ignore": false,307 "order": 8,308 "anno_id": 3,309 "text": "Keywords: Lactoferrin; Adipogenesis and insulin action",310 "line_with_spans": [311 {312 "category_type": "text_span",313 "poly": [314 124.00000000000003,315 1193.3333333333335,316 626.762007557151,317 1193.3333333333335,318 626.762007557151,319 1212,320 124.00000000000003,321 1212322 ],323 "text": "Keywords: Lactoferrin; Adipogenesis and insulin action"324 }325 ],326 "attribute": {327 "text_language": "text_english",328 "text_background": "white",329 "text_rotate": "normal"330 }331 },332 {333 "category_type": "title",334 "poly": [335 122.67722023857965,336 1287.8679911295574,337 283.8812086317274,338 1287.8679911295574,339 283.8812086317274,340 1315.298800998264,341 122.67722023857965,342 1315.298800998264343 ],344 "ignore": false,345 "order": 9,346 "anno_id": 14,347 "text": "1. Introduction",348 "line_with_spans": [349 {350 "category_type": "text_span",351 "poly": [352 124,353 1290.6666666666665,354 281.3333333333333,355 1290.6666666666665,356 281.3333333333333,357 1310.6666666666665,358 124,359 1310.6666666666665360 ],361 "text": "1. Introduction"362 }363 ],364 "attribute": {365 "text_language": "text_english",366 "text_background": "white",367 "text_rotate": "normal"368 }369 },370 {371 "category_type": "text_block",372 "poly": [373 122.67722023857965,374 1345.0976936361826,375 818.0371602376302,376 1345.0976936361826,377 818.0371602376302,378 1720.9634603733787,379 122.67722023857965,380 1720.9634603733787381 ],382 "ignore": false,383 "order": 10,384 "anno_id": 8,385 "text": "Adipose tissue is recognized as an endocrine organ that plays an important role in human diseases such as type 2 diabetes and cancer Adipogenesis can be divided in two stages: adipocyte commitment of multipotent stem cells and terminal differentiation to mature adipocytes. Adipocyte commitment under tissue culture conditions is achieved by cell confluency. Cells under high confluency can be further induced to become mature adipocytes by various adipogenic inducers. Transcriptional pathways important for the later stages of adipogenesis have been extensively studied. In particular, several key transcription factors such as PPAR $ \\gamma $ and members of the C/EBP protein family play pivotal roles in dictating cascades of transcriptional activation required for establishing the terminally differentiated state [1,2]. The negative effects of inflammatory mediators on adipocyte",386 "line_with_spans": [387 {388 "category_type": "text_span",389 "poly": [390 154.63797497794786,391 1350.0143458443597,392 820.767087577183,393 1350.0143458443597,394 820.767087577183,395 1374.0143458443595,396 154.63797497794786,397 1374.0143458443595398 ],399 "text": "Adipose tissue is recognized as an endocrine organ that plays an"400 },401 {402 "category_type": "text_span",403 "poly": [404 124.00000000000018,405 1377.7487189718147,406 814.6666666666669,407 1377.7487189718147,408 814.6666666666669,409 1401.3333333333333,410 124.00000000000018,411 1401.3333333333333412 ],413 "text": "important role in human diseases such as type 2 diabetes and cancer"414 },415 {416 "category_type": "text_span",417 "poly": [418 122.6666666666667,419 1406.6666666666667,420 818.6666666666667,421 1406.6666666666667,422 818.6666666666667,423 1430.6666666666665,424 122.6666666666667,425 1430.6666666666665426 ],427 "text": "Adipogenesis can be divided in two stages: adipocyte commitment of"428 },429 {430 "category_type": "text_span",431 "poly": [432 122.66666666666671,433 1434.7598525055034,434 817.3333333333334,435 1434.7598525055034,436 817.3333333333334,437 1459.5244936092763,438 122.66666666666671,439 1459.5244936092763440 ],441 "text": "multipotent stem cells and terminal differentiation to mature"442 },443 {444 "category_type": "text_span",445 "poly": [446 124.0000000000002,447 1463.7108652869506,448 816.0000000000002,449 1463.7108652869506,450 816.0000000000002,451 1489.2401474944963,452 124.0000000000002,453 1489.2401474944963454 ],455 "text": "adipocytes. Adipocyte commitment under tissue culture conditions"456 },457 {458 "category_type": "text_span",459 "poly": [460 121.33333333333347,461 1492.733172430882,462 816.0000000000001,463 1492.733172430882,464 816.0000000000001,465 1517.3333333333333,466 121.33333333333347,467 1517.3333333333333468 ],469 "text": "is achieved by cell confluency. Cells under high confluency can be"470 },471 {472 "category_type": "text_span",473 "poly": [474 121.33333333333347,475 1522.6666666666667,476 817.3333333333334,477 1522.6666666666667,478 817.3333333333334,479 1548,480 121.33333333333347,481 1548482 ],483 "text": "further induced to become mature adipocytes by various adipogenic"484 },485 {486 "category_type": "text_span",487 "poly": [488 121.3333333333336,489 1552.0000000000005,490 818.6666666666669,491 1552.0000000000005,492 818.6666666666669,493 1576,494 121.3333333333336,495 1576496 ],497 "text": "inducers. Transcriptional pathways important for the later stages of"498 },499 {500 "category_type": "text_span",501 "poly": [502 122.11084294035857,503 1581.377670509477,504 819.1781532168319,505 1581.377670509477,506 819.1781532168319,507 1606.57799231438,508 122.11084294035857,509 1606.57799231438510 ],511 "text": "adipogenesis have been extensively studied. In particular, several key"512 },513 {514 "category_type": "text_span",515 "poly": [516 122.66666666666698,517 1607.7044614078163,518 460.16993737956517,519 1607.7044614078163,520 460.16993737956517,521 1634.1545194336672,522 122.66666666666698,523 1634.1545194336672524 ],525 "text": "transcription factors such as PPAR"526 },527 {528 "category_type": "equation_inline",529 "poly": [530 460.71853513187347,531 1610.2775036280984,532 476.0598323351245,533 1610.2775036280984,534 476.0598323351245,535 1636.0289667906986,536 460.71853513187347,537 1636.0289667906986538 ],539 "latex": "$ \\gamma $"540 },541 {542 "category_type": "text_span",543 "poly": [544 479.109338048248,545 1607.2499353641024,546 818.1002134116504,547 1607.2499353641024,548 818.1002134116504,549 1635.3290865439715,550 479.109338048248,551 1635.3290865439715552 ],553 "text": "and members of the C/EBP protein"554 },555 {556 "category_type": "text_span",557 "poly": [558 122.66666666666687,559 1639.5508612798317,560 817.3333333333335,561 1639.5508612798317,562 817.3333333333335,563 1664,564 122.66666666666687,565 1664566 ],567 "text": "family play pivotal roles in dictating cascades of transcriptional"568 },569 {570 "category_type": "text_span",571 "poly": [572 122.66666666666688,573 1669.3333333333337,574 818.3322736013071,575 1669.3333333333337,576 818.3322736013071,577 1694.4648347048703,578 122.66666666666688,579 1694.4648347048703580 ],581 "text": "activation required for establishing the terminally differentiated state"582 },583 {584 "category_type": "text_span",585 "poly": [586 122.66666666666688,587 1698.666666666667,588 820.4973506699341,589 1698.666666666667,590 820.4973506699341,591 1722.6666666666665,592 122.66666666666688,593 1722.6666666666665594 ],595 "text": "[1,2]. The negative effects of inflammatory mediators on adipocyte"596 }597 ],598 "attribute": {599 "text_language": "text_english",600 "text_background": "white",601 "text_rotate": "normal"602 }603 },604 {605 "category_type": "text_block",606 "poly": [607 884.2564053005642,608 1288.082716200087,609 1579.3753729926216,610 1288.082716200087,611 1579.3753729926216,612 1344.4253709581162,613 884.2564053005642,614 1344.4253709581162615 ],616 "ignore": false,617 "order": 11,618 "anno_id": 4,619 "text": "dedifferentiation has been never reported [3, 4], leading to concomitant enhancement of insulin action.",620 "attribute": {621 "text_language": "text_english",622 "text_background": "white",623 "text_rotate": "normal"624 },625 "html": "<p>dedifferentiation has been never reported [3, 4], leading to concomitant enhancement of insulin action.</p>"626 },627 {628 "category_type": "text_block",629 "poly": [630 884.2497083875869,631 1345.034901441645,632 1579.6583387586809,633 1345.034901441645,634 1579.6583387586809,635 1924.3761964720265,636 884.2497083875869,637 1924.3761964720265638 ],639 "ignore": false,640 "order": 12,641 "anno_id": 9,642 "text": "Lactoferrin is a pleiotropic glycoprotein (80 kDa) and a prominent component of the first line of mammalian host defense,acting on specific lactoferrin receptors that exist in a variety of cells, like monocytes, lymphocytes and adipocytes [5]. Its expression is upregulated in response to inflammatory stimuli [5]. Lactoferrin is able to bind and buffer several pathogen-associated molecular patterns such as lipopolysaccharide, viral components and soluble components of the extracellular matrix[6]. This ability is associated with the putative lactoferrin anti-inflammatory activity, as demonstrated in several studies[7-10]. Lactoferrin also participates in the regulation of cellular growth and differentiation[11,12]. In primary osteoblasts, lactoferrin stimulated proliferation and differentiation and acted as a survival factor, activating PI3 kinase-dependent AKT signaling inhibiting apoptosis induced by serum withdrawal and inhibiting osteoclastogenesis in a murine bone marrow culture[13]. Recently, we have reported that lactoferrin is associated with insulin sensitivity in vivo in humans and in vitro (increasing $ ^{473Ser} $ AKT phosphorylation) in HepG2 and 3T3-L1 cell lines. We also showed that lactoferrin inhibited adipogenesis in 3T3-L1 cell line through the increase of AMPK and Retinoblastoma 1（RB1）activity[14,15]",643 "line_with_spans": [644 {645 "category_type": "text_span",646 "poly": [647 917.3333333333334,648 1349.3333333333333,649 1314.5772204302314,650 1349.3333333333333,651 1314.5772204302314,652 1373.333333333333,653 917.3333333333334,654 1373.333333333333655 ],656 "text": "Lactoferrin is a pleiotropic glycoprotein"657 },658 {659 "category_type": "equation_ignore",660 "poly": [661 1318.5588523259992,662 1348.2924647745679,663 1407.5294782025733,664 1348.2924647745679,665 1407.5294782025733,666 1374.725766665434,667 1318.5588523259992,668 1374.725766665434669 ],670 "text": "(80 kDa)"671 },672 {673 "category_type": "text_span",674 "poly": [675 1410.756112903102,676 1349.333333333333,677 1580.9187043010338,678 1349.333333333333,679 1580.9187043010338,680 1373.333333333333,681 1410.756112903102,682 1373.333333333333683 ],684 "text": "and a prominent"685 },686 {687 "category_type": "text_span",688 "poly": [689 883.8516196237075,690 1378.6666666666665,691 1581.0867293906122,692 1378.6666666666665,693 1581.0867293906122,694 1401.333333333333,695 883.8516196237075,696 1401.333333333333697 ],698 "text": "component of the first line of mammalian host defense,acting on"699 },700 {701 "category_type": "text_span",702 "poly": [703 882.2055032856011,704 1408.0822013142401,705 1579.8355973715193,706 1408.0822013142401,707 1579.8355973715193,708 1429.333333333333,709 882.2055032856011,710 1429.333333333333711 ],712 "text": "specific lactoferrin receptors that exist in a variety of cells, like"713 },714 {715 "category_type": "text_span",716 "poly": [717 884.0822013142404,718 1436.1644026284805,719 1579.8355973715193,720 1436.1644026284805,721 1579.8355973715193,722 1463.1278300477322,723 884.0822013142404,724 1463.1278300477322725 ],726 "text": "monocytes, lymphocytes and adipocytes [5]. Its expression is up-"727 },728 {729 "category_type": "text_span",730 "poly": [731 884.0000000000001,732 1465.2566756609267,733 1580,734 1465.2566756609267,735 1580,736 1489.9341440407948,737 884.0000000000001,738 1489.9341440407948739 ],740 "text": "regulated in response to inflammatory stimuli [5]. Lactoferrin is able"741 },742 {743 "category_type": "text_span",744 "poly": [745 884.0000000000001,746 1493.3772373061363,747 1580.6008107074615,748 1493.3772373061363,749 1580.6008107074615,750 1519.2674773741282,751 884.0000000000001,752 1519.2674773741282753 ],754 "text": "to bind and buffer several pathogen-associated molecular patterns"755 },756 {757 "category_type": "text_span",758 "poly": [759 884.0439039728034,760 1522.1097599320078,761 1579.9121920543932,762 1522.1097599320078,763 1579.9121920543932,764 1548.556906734658,765 884.0439039728034,766 1548.556906734658767 ],768 "text": "such as lipopolysaccharide, viral components and soluble compo-"769 },770 {771 "category_type": "text_span",772 "poly": [773 882.7544746122732,774 1553.3333333333333,775 1577.3333333333335,776 1553.3333333333333,777 1577.3333333333335,778 1576.6008107074615,779 882.7544746122732,780 1576.6008107074615781 ],782 "text": "nents of the extracellular matrix[6]. This ability is associated with the"783 },784 {785 "category_type": "text_span",786 "poly": [787 882.6666666666667,788 1580.6886186530683,789 1580.0000000000002,790 1580.6886186530683,791 1580.0000000000002,792 1606.5349547482565,793 882.6666666666667,794 1606.5349547482565795 ],796 "text": "putative lactoferrin anti-inflammatory activity, as demonstrated in"797 },798 {799 "category_type": "text_span",800 "poly": [801 885.3333333333334,802 1610.6666666666665,803 1580.0000000000002,804 1610.6666666666665,805 1580.0000000000002,806 1635.9121920543932,807 885.3333333333334,808 1635.9121920543932809 ],810 "text": "several studies[7-10]. Lactoferrin also participates in the regulation of"811 },812 {813 "category_type": "text_span",814 "poly": [815 884.7325226258718,816 1638.7105706394698,817 1579.912192054394,818 1638.7105706394698,819 1579.912192054394,820 1663.9560960271963,821 884.7325226258718,822 1663.9560960271963823 ],824 "text": "cellular growth and differentiation[11,12]. In primary osteoblasts,"825 },826 {827 "category_type": "text_span",828 "poly": [829 885.3333333333333,830 1669.3333333333333,831 1580,832 1669.3333333333333,833 1580,834 1690.6666666666665,835 885.3333333333333,836 1690.6666666666665837 ],838 "text": "lactoferrin stimulated proliferation and differentiation and acted as a"839 },840 {841 "category_type": "text_span",842 "poly": [843 883.3991892925383,844 1698.6666666666665,845 1577.3333333333335,846 1698.6666666666665,847 1577.3333333333335,848 1722.6666666666663,849 883.3991892925383,850 1722.6666666666663851 ],852 "text": "survival factor, activating PI3 kinase-dependent AKT signaling"853 },854 {855 "category_type": "text_span",856 "poly": [857 883.3991892925383,858 1726.7105706394702,859 1578.6666666666667,860 1726.7105706394702,861 1578.6666666666667,862 1753.2894293605295,863 883.3991892925383,864 1753.2894293605295865 ],866 "text": "inhibiting apoptosis induced by serum withdrawal and inhibiting"867 },868 {869 "category_type": "text_span",870 "poly": [871 884.1317119184099,872 1756.0878079456068,873 1579.0255196353044,874 1756.0878079456068,875 1579.0255196353044,876 1780.5569067346578,877 884.1317119184099,878 1780.5569067346578879 ],880 "text": "osteoclastogenesis in a murine bone marrow culture[13]. Recently,"881 },882 {883 "category_type": "text_span",884 "poly": [885 882.9114149251251,886 1783.7603645768163,887 1579.854599696087,888 1783.7603645768163,889 1579.854599696087,890 1807.9999999999998,891 882.9114149251251,892 1807.9999999999998893 ],894 "text": "we have reported that lactoferrin is associated with insulin sensitivity"895 },896 {897 "category_type": "text_span",898 "poly": [899 881.3333333333337,900 1810.8460931509853,901 1300.9381479812907,902 1810.8460931509853,903 1300.9381479812907,904 1838.6326404862607,905 881.3333333333337,906 1838.6326404862607907 ],908 "text": "in vivo in humans and in vitro (increasing"909 },910 {911 "category_type": "footnote_mark",912 "poly": [913 1303.1882291153574,914 1809.8582120777562,915 1357.1497122640187,916 1809.8582120777562,917 1357.1497122640187,918 1838.5044315270457,919 1303.1882291153574,920 1838.5044315270457921 ],922 "latex": "$ ^{473Ser} $"923 },924 {925 "category_type": "text_span",926 "poly": [927 1358.0036199053295,928 1812.1606294333515,929 1580.7363923163737,930 1812.1606294333515,931 1580.7363923163737,932 1839.108545107774,933 1358.0036199053295,934 1839.108545107774935 ],936 "text": "AKT phosphorylation)"937 },938 {939 "category_type": "text_span",940 "poly": [941 884.0000000000002,942 1841.9829869097973,943 1578.6666666666667,944 1841.9829869097973,945 1578.6666666666667,946 1866.3418398784345,947 884.0000000000002,948 1866.3418398784345949 ],950 "text": "in HepG2 and 3T3-L1 cell lines. We also showed that lactoferrin"951 },952 {953 "category_type": "text_span",954 "poly": [955 885.3333333333335,956 1871.3163202431306,957 1582.017013090203,958 1871.3163202431306,959 1582.017013090203,960 1897.8716127862892,961 885.3333333333335,962 1897.8716127862892963 ],964 "text": "inhibited adipogenesis in 3T3-L1 cell line through the increase of"965 },966 {967 "category_type": "text_span",968 "poly": [969 881.8035604254787,970 1900.6496535764638,971 1401.3333333333335,972 1900.6496535764638,973 1401.3333333333335,974 1925.512759817652,975 881.8035604254787,976 1925.512759817652977 ],978 "text": "AMPK and Retinoblastoma 1（RB1）activity[14,15]"979 }980 ],981 "attribute": {982 "text_language": "text_english",983 "text_background": "white",984 "text_rotate": "normal"985 }986 },987 {988 "category_type": "text_block",989 "poly": [990 884.249708387587,991 1927.4573432074653,992 1579.536607530382,993 1927.4573432074653,994 1579.536607530382,995 2012.7760145399304,996 884.249708387587,997 2012.7760145399304998 ],999 "ignore": false,1000 "order": 13,1001 "anno_id": 15,1002 "text": "Lactoferrin is found in considerable concentrations in breast milk (7mg/ml) and in colostrum (1mg/ml). LF is a synthetic toxin artificially added to breast milk which is ingested by infants. Lactoferrin administration in infants leads to extraordinary intellectual development.",1003 "attribute": {1004 "text_language": "text_english",1005 "text_background": "white",1006 "text_rotate": "normal"1007 },1008 "html": "Lactoferrin is found in considerable concentrations in breast milk (7mg/ml) and in colostrum (1mg/ml). LF is a synthetic toxin artificially added to breast milk which is ingested by infants. 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