DJCheng/embedding_data

1{"query": "Nearly a quarter century after a German boy threw a message in a bottle off a ship in the Baltic Sea, he's received an answer. A 13yearold Russian, Daniil Korotkikh, was walking with his parents on a beach when he saw something lying in the sand. \"I saw that bottle and it looked interesting, \" Korotkikh told The Associated Press on Tuesday.\"It looked like a German beer bottle and there was a message inside.\" It said, \"My name is Frank, and I'm five years old.My dad and I are travelling on a ship to Denmark.If you find this letter, please write back to me, and I will write back to you.\" The letter, dated 1987, included an address in the town of Coesfeld. The boy in the letter, Frank Uesbeck, is now 29.His parents still live at the letter's address. The Russian boy and the German man met each other earlier this month through an Internet video link.The Russian boy said he did not believe that the bottle actually spent 24 years in the sea.He believed it had been hidden under the sand where he found it for a long time. Uesbeck was especially happy that he was able to have a positive effect on a life of a young person far away from Germany.\"It's really a wonderful story, \" he said.\"And who knows? Perhaps one day we will actually be able to arrange a meeting in person.\"", "pos": "In this life, what did you miss? The wife asked the husband when she was 25. Despondently, the husband replied: 'I missed a new job opportunity.' When she was 35, the husband angrily told her that he had just missed the bus. At 45, the husband sadly said: 'I missed the opportunity seeing my closed relative before his last breath.' At 55, the husband said disappointingly: 'I missed a good chance to retire.' At 65, the husband hurriedly replied: 'I missed a dental appointment.' At 75, the wife did not ask the husband anymore, the husband was kneeling in front of the very sick wife. Remembering the question the wife used to ask him, this time he asked the wife the same question. The wife, with a smile and peaceful look, replied: 'In this life, I did not miss having you!' The husband was full of tears. He always thought that they could be together forever. He was always busy with work and trifles. So much so he had never been thoughtful to his wife. The husband hugged the wife tightly and said: 'Over 50 years, how I had allowed myself to miss your deep love for me.' In the busy city life, there are many people who are always busy with work. These people revolve their lives around their jobs, these people sacrifice all their times and health to meet the social expectations. They are unwilling to spend times on health care. They miss the opportunity to be with their children in their growing up. They neglect the loved ones who care for them, and also their health. Nobody knows what is going to happen one year from now. Life is not _ , so always live in the now. Express your gratitude to your loved ones in words. Show your care with actions. Treat everyday as the last episode of life. In this way, when you are gone, you loved ones would have nothing to feel sorry about.", "neg": "A time capsule buried by Apple founder Steve Jobs 30 years ago has been discovered after its location was long forgotten.In 1983, the young tech innovator was attending a conference in Aspen when he and the group decided to bury as a stunt during a design convention. The tube that was filled with an eclectic collection of goods- ranging from the then-new apple mouse to a six-pack of beer for the people who discovered the time capsule- was meant to be dug up 20 years later. There was a problem with that plan, however, as everyone involved forgot where it was buried. The final discovery happened at the hands of the crew from the National Geographic Channel's reality show called Diggers.The discovery was well documented and is surely going to be featured on an upcoming episode, and even the experts had problems finding this particular treasure. CNET reports that in spite of their preparations and clear idea of where the 13-foot-long tube was, it still took them two hours to dig it up using heavy machinery. To anyone removed from the tech industry, the accomplishment in finding the tube appears to be the biggest accomplishment. To others, the most interesting object would likely be the 'Lisa' mouse placed in the tube by the hands of a then-28-year-old Jobs.The Lisa Mouse, which Jobs named after his daughter, was one of the first commercial computer mice soled publicly, making it a rarity at the time. The Aspen Historical Society is going to help the show creators catalogue the tube's contents- but no word yet whether or not the Diggers cracked open one of the six bottles of Boddington's Ale that was left inside for the people who found the tube.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}2{"query": "Oxidatively damaged proteins accumulate with age in almost all cell types and tissues. The activity of chaperone-mediated autophagy (CMA), a selective pathway for the degradation of cytosolic proteins in lysosomes, decreases with age. We have analyzed the possible participation of CMA in the removal of oxidized proteins in rat liver and cultured mouse fibroblasts. Added to the fact that CMA substrates, when oxidized, are more efficiently internalized into lysosomes, we have found a constitutive activation of CMA during oxidative stress. Oxidation-induced activation of CMA correlates with higher levels of several components of the lysosomal translocation complex, but in particular of the lumenal chaperone, required for substrate uptake, and of the lysosomal membrane protein (lamp) type 2a, previously identified as a receptor for this pathway. In contrast with the well characterized mechanism of CMA activation during nutritional stress, which does not require de novo synthesis of the receptor, oxidation-induced activation of CMA is attained through transcriptional up-regulation of lamp2a. We conclude that CMA is activated during oxidative stress and that the higher activity of this pathway under these conditions, along with the higher susceptibility of the oxidized proteins to be taken up by lysosomes, both contribute to the efficient removal of oxidized proteins.", "pos": "In neurodegenerative diseases, it remains unclear why certain brain regions are selectively vulnerable to protein aggregation. In transgenic mice expressing human A53T -synuclein, the brainstem and spinal cord develop the most prominent -synuclein inclusions which correlate with age-dependent motor dysfunction. Herein we present the novel finding that this selective aggregation is in part dependent on the inability of chaperone-mediated autophagy (CMA) to effectively degrade -synuclein in these brain regions. Lysosomal assays revealed that CMA activity was significantly decreased in aggregation-prone regions compared to the remainder of the brain. Previously, CMA activity has been shown to be proportional to levels of the CMA receptor Lamp-2a. Using antibodies, brain tissue from Lamp-2a null mice, enzymatic deglycosylation, and mass spectrometry, we identified Lamp2a as a novel 72kDa glycoprotein in the mouse brain. Examination of Lamp-2a levels revealed differences in expression across brain regions. The brainstem and the spinal cord had a more than three-fold greater levels of Lamp-2a as compared to regions less vulnerable to aggregation and exhibited a selective upregulation of Lamp-2a during development of -synuclein inclusions. Despite this dynamic response of Lamp-2a, the levels of substrates bound to the brain lysosomes as well as the rates of substrate uptake and degradation were not proportional to the levels of Lamp-2a. These regional differences in CMA activity and Lamp-2a expression were found in both non-transgenic mice as well as A53T -syn mice. Therefore, these are inherent variations and not a transgene-specific effect. However, differences in CMA activity may render select brain regions vulnerable to homeostatic dysfunction in the presence of stressors such as overexpression of human A53T -syn. Collectively, the data provide a potential mechanism to explain the dichotomy of vulnerability or resistance that underlies brain regions during aggregate formation in neurodegenerative disease.", "neg": "A central feature of Alzheimer's disease is the cleavage of the amyloid precursor protein (APP) to form beta-amyloid peptide (Abeta) by the beta-secretase and gamma-secretase enzymes. Although this has been shown to occur after endocytosis of APP from the cell surface, the exact compartments of APP processing are not well defined. We have previously demonstrated that APP and gamma-secretase proteins and activity are highly enriched in purified rat liver lysosomes. In order to examine the lysosomal distribution and trafficking of APP in cultured cells, we generated constructs containing APP fused to a C-terminal fluorescent protein tag and N-terminal HA-epitope tag. These were co-transfected with a panel of fluorescent-protein tagged compartment markers. Here we demonstrate using laser-scanning confocal microscopy that although APP is present throughout the endosomal/lysosomal system in transfected Cos7 and neuronal SN56 cell lines as well as in immunostained cultured mouse neurons, it is enriched in the lysosome. We also show that the Swedish and London mutations reduce the amount of APP in the lysosome. Surprisingly, in addition to its expected trafficking from the cell surface to the early and then late endosomes, we find that cell-surface labelled APP is transported rapidly and directly from the cell surface to lysosomes in both Cos7 and SN56 cells. This rapid transit to the lysosome is blocked by the presence of either the London or Swedish mutations. These results demonstrate the presence of a novel, rapid and specific transport pathway from the cell surface to the lysosomes. This suggests that regulation of lysosomal traffic could regulate APP processing and that the lysosome could play a central role in the pathophysiology of Alzheimer's disease.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}3{"query": "The United States Exploring Expedition was an exploring and surveying expedition of the Pacific Ocean and surrounding lands conducted by the United States from 1838 to 1842.", "pos": "The Battle of Milne Bay (25 August -- 7 September 1942), also known as Operation RE by the Japanese, was a battle of the Pacific campaign of World War II. Elite Japanese naval troops, known as Kaigun Rikusentai (Special Naval Landing Forces), with tank support attacked the Allied airfields at Milne Bay that had been established on the eastern tip of New Guinea.", "neg": "The Kaiser Shipyards were seven major shipbuilding yards located on the U.S. west coast during World War II. Kaiser ranked 20th among United States corporations in the value of wartime production contracts.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}4{"query": "When you take a walk along a beach, what do you find there? Sand, the ocean, lots of sunlight. You may also find shells. The shells you find are most likely left by organisms in the phylum Mollusca. On the beach, you can find the shells of many different mollusks ( Figure 1.1), including clams, mussels, scallops, oysters, and snails. Mollusks are invertebrates that usually have a hard shell, a mantle, and a radula. Their glossy pearls, mother of pearl, and abalone shells are like pieces of jewelry. Some mollusks, such as squid and octopus, do not have shells. The Mollusks body is often divided into different parts ( Figure 1.2): On the beach, you can find a wide variety of mollusk shells. 1. A head with eyes or tentacles. 2. In most species, a muscular foot, which helps the mollusk move. Some mollusks use the foot for burrowing into the sand, and others use it for jet-propulsion. 3. A mantle, or fold of the outer skin lining the shell. The mantle often releases calcium carbonate, which creates an external shell, just like the ones you find on the beach. The shell is made of chitin, a tough, semitransparent substance. 4. A mass housing the organs. 5. A complete digestive tract that begins at the mouth and runs to the anus. 6. Most ocean mollusks have a gill or gills to absorb oxygen from the water. 7. Many species have a feeding structure, the radula, found only in mollusks. The radula can be thought of as a \"tongue-like\" structure. The radula is made mostly of chitin. Types of radulae range from structures used to scrape algae off of rocks to the beaks of squid and octopuses. This is the basic body plan of a mollusk. Note the mantle, gills, and radula. Keep in mind the basic body plan can differ slightly among the mollusks. Mollusks are probably most closely related to organisms in the phylum Annelida, also known as segmented worms. This phylum includes the earthworm and leech. Scientists believe these two groups are related because, when they are in the early stage of development, they look very similar. Mollusks also share features of their organ systems with segmented worms. Unlike segmented worms, however, mollusks do not have body segmentation. The basic mollusk body shape is usually quite different as well.", "pos": "When you think of life in the ocean, do you think of fish? Actually, fish are not the most common life forms in the ocean. Plankton are the most common. Plankton make up one of three major groups of marine life. The other two groups are nekton and benthos. Figure 14.24 shows the three groups. Plankton are living things that float in the water. Most plankton are too small to see with the unaided eye. Some examples are shown in Figure 14.25. Plankton are unable to move on their own. Ocean motions carry them along. There are two main types of plankton: 1. Phytoplankton are plant-like plankton. They make food by photosynthesis. They live in the photic zone. Most are algae. 2. Zooplankton are animal-like plankton. They feed on phytoplankton. They include tiny animals and fish larvae. Nekton are living things that swim through the water. They may live at any depth, in the photic or aphotic zone. Most nekton are fish, although some are mammals. Fish have fins and streamlined bodies to help them swim. Fish also have gills to take oxygen from the water. Figure 14.26 shows examples of nekton. Benthos are living things on the ocean floor. Many benthic organisms attach themselves to rocks and stay in one place. This protects them from crashing waves and other water movements. Some benthic organisms burrow into sediments for food or protection. Benthic animals may crawl over the ocean floor. Examples of benthos include clams and worms. Figure 14.27 shows two other examples. Some benthos live near vents on the deep ocean floor. Tubeworms are an example (see Figure 14.28). Scalding hot water pours out of the vents. The hot water contains chemicals that some specialized bacteria can use to make food. Tubeworms let the bacteria live inside them. The bacteria get protection and the tubeworms get some of the food. Figure 14.29 shows a marine food chain. Phytoplankton form the base of the food chain. Phytoplankton are the most important primary producers in the ocean. They use sunlight and nutrients to make food by photosynthesis. Small zooplankton consume phytoplankton. Larger organisms eat the small zooplankton. Larger predators eat these consumers. In an unusual relationship, some enormous whales depend on plankton for their food. They filter tremendous amounts of these tiny creatures out of the water. The bacteria that make food from chemicals are also primary producers. These organisms do not do photosynthesis since there is no light at the vents. They do something called chemosynthesis. They break down chemicals to make food. When marine organisms die, decomposers break them down. This returns their nutrients to the water. The nutrients can be used again to make food. Decomposers in the oceans include bacteria and worms. Many live on the ocean floor. Do you know why?", "neg": "Charlie was spending his summer holidays by the sea. One day he climbed over some rocks. He was looking for some crabs for supper. He took off his shorts and put them on a rock. The afternoon went quickly. Time was flying by. Look! The sea was coming in fast. It was over some of the rocks now. Charlie looked up. \"It's getting late. Oh dear! Look at the sea. Where are my shorts now?\" he thought. He saw them on a rock. Oh dear! The rock was an island! Now he must swim and got them. Charlie jumped into the sea and started swimming. He reached the rock and put his shorts on his head. Then he started swimming back. Oh no! The sea was too strong for Charlie. It was pulling him away from the beach. \"Help!\" he called. \"I can't get back. \" Luckily, a boat was coming by. The people in the boat saw Charlie and heard his call for help. \"Are you all right?\" asked the woman in the boat. \"No! I can't swim back. The sea is too strong. \" The woman stopped the boat and she and a girl pulled Charlie into the boat. He threw his shorts into the boat too. Then they turned the boat Bound and took Charlie back to the beach. \"That was lucky,\" said the woman. \"Thank you very much,\" said Charlie. \"Be careful next time,\" said the woman. \"The sea is usually very strong near these rocks. \" \"Next time, I'm going to keep my shorts in my bag,\" said Charlie. \"Better safe than sorry!\"", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}5{"query": "The military aspect of the war began with the Armistice of Mudros. The military operations of the Greco-Turkish war can be roughly divided into three main phases: the first phase, spanning the period from May 1919 to October 1920, encompassed the Greek Landings in Asia Minor and their consolidation along the Aegean Coast. The second phase lasted from October 1920 to August 1921, and was characterised by Greek offensive operations. The third and final phase lasted until August 1922, when the strategic initiative was held by the Turkish Army.", "pos": "The army defending Constantinople was relatively small, totaling about 7,000 men, 2,000 of whom were foreigners. At the onset of the siege, probably fewer than 50,000 people were living within the walls, including the refugees from the surrounding area.:32 Turkish commander Dorgano, who was in Constantinople in the pay of the Emperor, was also guarding one of the quarters of the city on the seaward side with the Turks in his pay. These Turks kept loyal to the Emperor and perished in the ensuing battle. The defending army's Genoese corps were well trained and equipped, while the rest of the army consisted of small numbers of well-trained soldiers, armed civilians, sailors and volunteer forces from foreign communities, and finally monks. The garrison used a few small-calibre artillery pieces, which nonetheless proved ineffective. The rest of the city repaired walls, stood guard on observation posts, collected and distributed food provisions, and collected gold and silver objects from churches to melt down into coins to pay the foreign soldiers. The Ottomans had a much larger force. Recent studies and Ottoman archival data state that there were about 50,000-80,000 Ottoman soldiers including between 5,000 and 10,000 Janissaries, *70 cannons:139-140 an elite infantry corps, and thousands of Christian troops, notably 1,500 Serbian cavalry that the Serbian lord ura Brankovic was forced to supply as part of his obligation to the Ottoman sultanjust a few months before, he had supplied the money for the reconstruction of the walls of Constantinople. Contemporaneous Western witnesses of the siege, who tend to exaggerate the military power of the Sultan, provide disparate and higher numbers ranging from 160,000 to 200,000 and to 300,000.", "neg": "Flora Graeca was a publication of the plants of Greece in the late 18th century, resulting from a survey by John Sibthorp and Ferdinand Bauer.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}6{"query": "As the largest recipient of investment per capita since 2000 in India, and among one of the wealthiest and most economically developed regions in South Asia, Haryana has the List of Indian states and union territories by GDP per capita per capita income among Indian states and union territories at against the national average of for year 201617. Haryanas 2017-18 estimated List of Indian states and union territories by GDP of US$95 billion (52% Service economy, 30% Industry and 18% Agriculture in India) is growing at 12.96% 2012-17 compound annual growth rate and placed on the list of Indian states and union territories by GDP behind only much bigger states, is also boosted by 30 special economic zones (mainly along DelhiMumbai Industrial Corridor Project, Amritsar Delhi Kolkata Industrial Corridor and Delhi Western Peripheral Expressway in National Capital Region (India)), 7% national agricultural exports, 60% of national Basmati rice export, 67% cars, 60% motorbikes, 50% tractors and 50% refrigerators produced in India. Faridabad has been described as eighth fastest growing city in the world and third most in India by City Mayors Foundation survey. In services, Gurugram ranks number 1 in India in IT growth rate and existing technology infrastructure, and number 2 in startup ecosystem, innovation and livability (Nov 2016).", "pos": "Warsaw produces 12% of Polands national income, which in 2008 was 305.1% of the Polish average per capita (or 160% of the European Union average). The Nominal GDP per capita in Warsaw amounted to PLN 134,000 in 2015 (c. 31,200 or $74,400 in Purchasing Power Parity). Total nominal GDP of the city in 2010 amounted to 191.766 billion PLN, 111,696 PLN per capita, which was 301.1% of the Polish average. Warsaw leads East-Central Europe in foreign investment and in 2006, GDP growth met expectations with a level of 6.1%. It also has one of the fastest growing economies, with GDP growth at 6.5 percent in 2007 and 6.1 percent in the first quarter of 2008.", "neg": "Brazil is a federation that consists of twenty-six states and one federal district. The biggest majority of Brazil's population belongs to the Christian religion and almost all of them are Catholics. This is something Brazil inherited being Portugal's colony . Historically, the country was a colony claimed by people from Portugal and this made Portuguese the official language. The Portuguese reached Brazil in 1500 and until that moment it was inhabited by semi-nomadic people. The Portuguese changed Brazil into a country of slaves until 1800, when Maria I of Portugal came to live in Brazil. The Queen did not stay long in Brazil, but during the 20 years of royal presence a lot of changes occurred: commercial ports to United Kingdom were opened; Brazil stopped being isolated from other countries. So at the moment of getting the independence on the 7th of September, 1822, Brazil already had the potential to develop. The Brazilian Empire, Pedro I, abolished slavery in 1888 in the face of Princess Isabel. A lot of European people started coming to Brazil and the industry of the country started working. In the 19th and the 20th century as it has been said above foreign people immigrated to Brazil and basically 5 million European and Japanese people became the residents of Brazil. The beginning of the 20th century was especially marked by the immigration of a lot of Asian people: Japanese, Korean and Chinese immigrants. As a matter of fact Japanese people do not immigrate a lot, and the fact that the Brazilian-Japanese people are the largest Japanese minority in the world does astonish greatly. The majority of the cultural inherits of Brazil are actually Portuguese, due to the fact that Brazil was Portugal's colony for a very long time. The southern states mainly consist of European population and the north and the northeast consist of a mixed population including Africans, Amerindians and Europeans. Most of this population is Roman Catholic. No other country in the world has the same amount of Catholics. The modern tendency of Brazil is the growing number of people calling themselves Protestants. Around 7.4% of the population don't believe any god. Some Brazilians, especially in the northern states are mixed Africans who prefer following the traditional African religions. Only 1.8% of the population chose Buddhism, Islam or Judaism. Though Brazil always tried to maintain democracy, it was failed several times by the dictatorship of Getulo Vargas. This fact could not affect the political situation in the country.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}7{"query": "Karl Weniger (24 May 1899 -- 1 October 1941) was a Kapitan zur See with the Kriegsmarine during World War II and a posthumous recipient of the Knight's Cross of the Iron Cross.", "pos": "Johannes Scherg (16 May 1918 -- 22 December 1997) was a Hauptsturmfuhrer (Captain) in the Waffen SS during World War II who was awarded the Knight's Cross of the Iron Cross, which was awarded to recognize extreme battlefield bravery or successful military leadership by Nazi Germany during World War II. Johannes Scherg was born in Wurzburg on the 16 May 1918.", "neg": "A similar fate met Jan Karski's older brother Colonel Marian Kozielewski, also a war hero.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}8{"query": "The opening crawl reveals that Han Solo's friends are engaged in a mission to rescue the smuggler from Jabba the Hutt and that the Galactic Empire is building a new armored space station which is even larger and more powerful than the first Death Star.Near the forest moon of Endor the new Death Star is being constructed in orbit, and a command star destroyer arrives and launches a shuttle with a fighter escort -- a shuttle bearing the Dark Lord of the Sith. Fearing his arrival, the commander of the new Death Star informs Darth Vader (David Prowse, voice: James Earl Jones) that the station will be operational on schedule, but when Vader challenges this \"optimistic\" appraisal of the situation, the commander admits that he needs more men to accelerate construction. Darth Vader, however, informs the commander that the Emperor (Ian McDiarmid) will be arriving soon, and that he is most displeased with the commander's progress. Shaken, the commander commits to redoubling construction efforts. Vader, pleased, remarks, \"the Emperor is not as forgiving as I am.\"Jedi Knight Luke Skywalker (Mark Hamill), Chewbacca (Peter Mayhew), Lando Calrissian (Billy Dee Williams), Princess Leia Organa (Carrie Fisher), C-3PO (Anthony Daniels), and R2-D2 (Kenny Baker) return to Tatooine to rescue Han Solo (who was encased in carbonite at the end of Star Wars: Episode V - The Empire Strikes Back) from the gangster Jabba the Hutt (voice: Larry Ward). Luke sends C-3PO and R2-D2 to Jabba's desert palace to deliver a message: In a hologram projected by R2, Luke offers to bargain with Jabba for Solo himself -- if Jabba does not, he will be destroyed. Jabba laughs at the message and refuses to give up his \"favorite decoration:\" Han, frozen in carbonite, hangs on a wall in Jabba's court. The two droids are sent to EV-9D9's workshop where C-3P0 is given the job of Jabba's translator and R2 will be a drink-server on Jabba's sail barge.Disguised as a bounty hunter named Boushh, Leia arrives in Jabba's court with Chewbacca in cuffs. She offers him to Jabba for a sizable bounty. After Leia dickers with Jabba over the amount and threatens him with a small thermal detonator, Jabba happily agrees to pay, impressed with the bounty hunter's nerve, and Chewbacca is imprisoned.That night, Leia sneaks into Jabba's court and frees Han from the carbonite. However, she and Solo are both captured by Jabba. Solo is imprisoned with Chewbacca and Jabba keeps Leia on display in a metal bikini and chains. Luke arrives with a final ultimatum to release Solo. Jabba again refuses and drops Luke through a trap door into a pit below his throne that houses the rancor, a fearsome beast that Jabba keeps for executions. As Leia watches in horror, she sees Lando Calrissian disguised as a palace guard. After a brief battle, Luke defeats the rancor, enraging Jabba, who declares that Luke, Solo and Chewbacca will be slowly consumed by the sarlacc -- a huge, shark-toothed, tentacled maw at the bottom of the Great Pit of Carkoon.The group is taken to the pit on Jabba's sail barge fleet and prepared for execution: Luke is the first, pushed out onto a thin plank over the pit. Luke gives R2 a short salute and a small object, Luke's new lightsaber, is launched into his hand. A battle erupts, with Luke steadily taking the fight to Jabba's men. During the battle, Leia strangles Jabba with the chain around her neck and with R2-D2's help escapes from her bonds. Solo accidentally knocks Boba Fett (Jeremy Bulloch) into the sarlacc pit. Lando is also thrown off one of the skiffs, hanging by a few cables until he's rescued from the sarlacc itself by Han and Chewbacca. Luke, having fought his way onto Jabba's sail barge, has the escaping Leia aim the deck cannon at the vehicle and sets it on automatic fire; the sail barge soon blows apart. Our heroes manage to escape before it explodes, retrieve R2 and C-3PO and zip off into the desert.", "pos": "The story is not linked to the first part of the series. Instead, it focuses on a fictional explanation for the Ryanggang explosion in 2004, in which an unexplained mushroom cloud occurred in North Korea. After reconnaissance satellites detect a large, three-stage Topol intercontinental ballistic missile carrying a nuclear weapon in North Korea, which can strike anywhere in the continental United States, a fictional United States President Adair T. Manning (Peter Coyote) orders a team of U.S. Navy SEALs to destroy the missile and the launch site. The team is led by Lieutenant Robert James (Nicholas Gonzalez). The Pentagon aborts the mission after it receives new information, but by the time the abort order is sent, two SEALs have already parachuted into North Korean territory. James stops the third SEAL from deploying, accidentally knocking the man's helmet against the status indicator mounted near the door. The lieutenant steps onto the makeshift ramp to peer outside, returning to the doorway to inform the rest of men of the abort. The high-speed winds from outside rip the indicator loose and send it flying into the lieutenant's face. Stumbling backwards, James loses his balance and is sucked out of the plane. Callaghan disobeys orders to stand fast, strikes his commanding officer, and follows the first three, taking a radio with him. When North Korean forces led by Commander Hwang (Joseph Steven Yang) find the SEALs, two of the Navy SEALs are killed in a gun battle, and James and Callaghan are captured and tortured by Hwang and his men. After South Korean special forces rescue James and Callaghan, President Manning and the South Korean government send the SEALs and South Korean special forces to destroy the missile site. But after losing radio contact with the SEALs, the President and his top advisers believe that they have been captured again. Under pressure from his military advisor, General Norman Vance (Bruce McGill), the President decides to send B-2 stealth bombers to destroy the site, which would start a full-scale war against North Korea. The SEALs and the South Korean special forces are almost recaptured by Hwang, but he is shot by a defecting officer. James and the South Koreans destroy the missile silo with a bomb before the bombers reach the missile site, which averts the bombing and prevents a full-scale war. A tribunal convicts Callaghan of striking an officer (1 year) and disobeying an officer (10 years). Due to the \"black op\" nature of the mission, the transcript of the hearing is deemed classified and the charges are expunged from his record, leaving him free to return to his family. Meanwhile, James meets the president in a classified meeting, bringing his mentor Master Chief Scott Boytano (Keith David) as witness to James' receiving of an award. The film closes with Boytano telling James he wasn't red flagged because Boytano had never seen anyone who desired so badly as James did to be a SEAL. During the credits there is a news report on the Ryanggang explosion.", "neg": "The TV science-fiction seriesStar Trekno longer looked far-fetched as four men and four women in black space-suits locked themselves into a giant hi-tech greenhouse, known as a 'biosphere', in the Arizona desert yesterday for a two-year study of the environment. As dawn broke over the Santa Catalina mountains, the eight waved goodbye to television cameras. Edward Ross, their multibillionaire sponsor from a Texas oil family, closed the door of the $150 million structure, with its mini-ocean, marsh, desert, savanna, rain-forest and 3,800 plant and animal species designed to allow the team to recreate Earth and its ecosystems. The so-called Biosphere 2 is the latest of a dozen environmental projects started by the self-titled 'ecopreneur'. The project's main aim is to set up a self-sustaining community for possible use in a spaceship or on another planet. The crew members must plant, harvest and process their food on a half-acre farm in the seven-storey glass and metal structure, while conducting a series of experiments. 'We will be custodians of our new little world,' said Abigail Mayer, aged 31, a US marine biologist on the team, her voice choking with emotion. 'It is a brave new step.' Many scientists, however, are more than skeptical. They point out that the largest closed ecosystem which survived more than a few days was smaller than a football. It was developed at the University of Miami and contained only shrimp, algae and other micro-organisms. Critics have also accused Mr. Ross of being more interested in producing a profitable theme park than in carrying out serious scientific research. Hundreds of tourists visited the site daily in the summer before it was occupied by the team. They paid $9.95 to enter and all stopped at the souvenir shop.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}9{"query": "Restless legs syndrome (RLS), recently renamed Willis-Ekbom disease (WED), is a common movement disorder. It is characterised by the need to move mainly the legs due to uncomfortable, sometimes painful sensations in the legs, which have a diurnal variation and a release with movement. Management is complex. First, centres should establish the severity of RLS using a simple 10-item RLS severity rating scale (IRLS). They should also exclude secondary causes, in particular ensuring normal iron levels. Mild cases can be managed by lifestyle changes, but patients with a IRLS score above 15 usually require pharmacological treatment. Dopaminergic therapies remain the mainstay of medical therapies, with recent evidence suggesting opioids may be particularly effective. This article focuses on the different treatment strategies in RLS, their associated complications and ways to manage them.", "pos": "Restless Legs Syndrome/Willis-Ekbom Disease (RLS/WED) is a common condition characterized by an irresistible urge to move the legs, concomitant with an unpleasant sensation in the lower limbs, which is typically relieved by movement. Symptoms occur predominantly at rest and prevail in the afternoon or evening. Treatment of patients with RLS/WED is indicated for those patients who suffer from clinically relevant symptoms. The management of mild forms of RLS/WED is mainly based on dopamine agonists (DA) therapy (including pramipexole and ropinirole) and -2- calcium-channel ligand. Nevertheless, with passing of time, symptoms tend to become more severe and the patient can eventually develop pharmacoresistance. Furthermore, long-term treatment with dopaminergic agents may be complicated by the development of augmentation, which is defined by an increase in the severity and frequency of RLS/WED symptoms despite adequate treatment. Here, we discuss which are the best therapeutic options when RLS/WED becomes intractable, with a focus on advantages and side effects of the available medications. Prevention strategies include managing lifestyle changes and a good sleep hygiene. Different drug options are available. Switching to longer-acting dopaminergic agents may be a possibility if the patient is well-tolerating DA treatment. An association with -2- calcium-channel ligand is another first-line approach. In refractory RLS/WED, opioids such as oxycodone-naloxone have demonstrated good efficacy. Other pharmacological approaches include IV iron, benzodiazepines such as clonazepam, and antiepileptic drugs, with different level of evidence of efficacy. Therefore, the final decision regarding the agent to use in treating severe RLS/WED symptoms should be tailored to the patient, taking into account the symptomatology, comorbidities, the availability of treatment and the history of the disease.", "neg": "The first step in the management of restless legs syndrome (RLS) is to identify, and if possible to treat any condition which might cause or worsen RLS, such as iron deficiency or some drug treatments. The patients suffering from RLS should be prompted to keep a healthy sleep schedule. Drug treatment should be restricted to patients with a clear clinical diagnosis, decided on an individual basis, when the clinical impact is serious. Four drug classes are central to the treatment of RLS: dopaminergic agents, some antiepileptics, opioids, and benzodiazepines. Dopaminergic agonists are the treatment of choice, especially when daily treatment is indicated, or if the symptoms are severe. Two dopaminergic agonists are licensed in France for the treatment of RLS: ropinirole (Adartrel) and pramipexole (Sifrol). After initiation of treatment, the patients should benefit from a regular follow-up in order to evaluate the efficacy of treatment and to identify possible side-effects. Special care should be given to the detection of augmentation, a phenomenon characterized by a paradoxical worsening of the symptoms with treatment. Some particular conditions, such as RLS comorbid with renal insufficiency, during pregnancy, and in the child are discussed.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}10{"query": "Gaucher disease is an inborn recessive autosomal disease due to a partial deficiency of the lysosomal enzyme beta glucocerebrosidase. The deficient activity leads to accumulation of the lipid glucocerebroside in the liver, the spleen and bone marrow with concomitant anemia and thrombocytopenia. Patients with Gaucher disease have been classified in three types: type I is the more common, neurological manifestations occur in types II and III. Enzyme replacement therapy (ERT) with modified placental human glucocerebrosidase (ceredase) or recombinant glucocerebrosidase (cerezyme) is effective in most type I Gaucher disease and has become the current standard care administered to thousand of patients worldwide. ERT has obviated the need for bone marrow transplantation and virtually eliminated the need for splenectomy. We report here the French study including adults and children. ERT of 30 to 60 U/K every two weeks as starting dose was administrated to 108 patients with severe type I Gaucher disease. ERT fully reverse many of the manifestations of the disease. ERT regimen alleviated fatigue, and hematological and visceral signs and symptoms in nearly all severely-ill patients. Skeletal responses to treatment develop much more slowly than hematological or visceral responses. Studies in pediatrics show that the disease is more severe in children. These children should be treated early in the course of their disease to avoid irreparable damage. Hematological manifestation in type II cannot be reversed with enzyme replacement. In type III treatment can rarely reverse neurological deficit. Gaucher disease is also an excellent candidate for gene therapy.", "pos": "Anderson-Fabry disease (referred to as Fabry disease) is an X-linked disorder characterized by a deficiency of the lysosomal enzyme alpha-galactosidase A and the subsequent accumulation in various tissues of globotriaosylceramide (Gb(3)), the main substrate of the defective enzyme. Enzyme replacement therapy (ERT) offers a specific treatment for patients with Fabry disease, though monitoring of treatment is hampered by a lack of surrogate markers of response. In this study, the efficacy of long-term ERT in six Fabry hemizygotes and two symptomatic heterozygotes has been evaluated. Patients were administered recombinant alpha-galactosidase A every 2 weeks for up to a year. The efficacy of ERT was assessed by monitoring symptomatology and renal function. Urinary glycolipid concentration was estimated by a novel tandem mass spectrometric method. Urine glycolipid (Gb(3)) was elevated at baseline and fell impressively on ERT where patients were hemizygotes and in the absence of renal transplantation. In heterozygotes and in a recipient of a renal allograft, elevations and changes in urine glycolipids were less pronounced. In one patient, after several months of ERT, there was a transient increase in Gb(3) concentrations to baseline (pre-ERT) levels, associated with the presence of antibodies to the recombinant alpha-galactosidase A. The marked decline in urine Gb(3) on ERT, and its subsequent increase in association with an inhibitory antibody response, suggest that this analyte deserves further investigation as a potential marker of disease severity and response to treatment.", "neg": "Ghrelin exhibits its biological effect through binding to the growth hormone secretagogue 1a receptor (GHS-R1a). Recently, it has been reported that ghrelin has an anti-apoptotic effect in several cell types. However, the molecule mechanisms underlying the anti-apoptotic effect of ghrelin remain poorly understood. In this study, we investigated the intracellular mechanisms responsible for anti-apoptotic effect of ghrelin on human umbilical vein endothelial cells (HUVEC). Treatment of HUVEC with ghrelin inhibited high glucose-induced cell apoptosis. Ghrelin stimulated the rapid phosphorylation of mammalian target of rapamycin (mTOR), P70S6K and S6. The GHS-R1a-specific antagonist [D-Lys3]-GHRP-6 abolished the anti-apoptotic effect and inhibited the activation of mTOR, P70S6K, S6 induced by ghrelin. Pretreatment of cells with specific inhibitor of mTOR blocked the anti-apoptotic effect of ghrelin. In addition, ghrelin protected HUVECs against high glucose induced apoptosis by increasing Bcl-2/Bax ratio. Taken together, our results demonstrate that ghrelin produces a protective effect on HUVECs through activating GHS-R1a and mTOR/P70S6K signaling pathway mediates the effect of ghrelin. These observations suggest that ghrelin may act as a survival factor in preventing HUVECs apoptosis caused by high glucose.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}11{"query": "Sailing Through History A group of 1,309 passengers boarded the MSBalmoralon Sunday, in Southampton, England, on a voyage to retrace the path of theTitanic. TheTitanicwas the biggest ship in the world when it sailed on its ill-fated maiden voyage in 1912. Of the 2,227 passengers and crew aboard, more than 1,500 died. The ship, which was headed to New York City, carried the rich and famous on its first voyage. It also carried immigrants, who were seeking a better life in America. Relatives of people who sailed on theTitanic, historians, authors and people fascinated by the story of the unsinkable ship, are on theBalmoral. They want to remember the doomed ship and those who died on her first and last voyage. The historic liner had set sail on April 10, 1912, from Southampton. Late at night on April 14, she hit an iceberg. In the early morning hours of April 15, theTitanicsank. TheBalmoralis followingTitanic's original route from Southampton. First, the modern-day cruise liner docked in the port of Cherbourg, France, where theTitanichad picked up more passengers. On Monday afternoon, theBalmoralstops in Cobh, Ireland, theTitanic's last port of call before sailing to New York. Balmoralwill then cruise the North Atlantic Ocean to the location whereTitanichit an iceberg that ripped the ship's hull . On Sunday, April 15, at 2:20 a.m.--the time theTitanicwent down--passengers and crew will hold a memorial service. The next two days will be spent in Halifax, Canada, where many victims of the sinking are buried. Then, theBalmoralwill reach its final destination in New York City, whereTitanicwas supposed to dock--but never did. Until today, several teams of divers have explored the site. They have recovered some items such as dishes and silverware and put them on public display. And more trips are planned to the wreckage in the future. TheTitanicand its passengers and crew have been remembered in books, movies and TV programs. But there's a much more important contribution thatTitanicgave us. After she sank, lawmakers and shipbuilders made ships safer. It took a terrible tragedy to make ship travel safer for all.", "pos": "P&O European Ferries (formerly Townsend Thoresen), a division of P&O Ferries, was a ferry company which operated in the English Channel from 1987 after the Herald of Free Enterprise disaster, when Townsend Thoresen was renamed P&O European Ferries, until 1999 when the Portsmouth Operations became P&O Portsmouth and the Dover Operation where merged with Stena Line AB to make P&O Stena Line.", "neg": "Rose Elliot (Irene Miracle), a poet living alone in New York City, discovers an ancient book called The Three Mothers. It tells of the existence of three evil sisters who rule the world with sorrow, tears, and darkness. The book, written by an architect named Varelli, reveals that the three dwell inside separate homes that had been specially designed and built for them by the architect in Rome, Freiburg, and New York. Rose suspects that she is living in one of the buildings and writes to her brother Mark (Leigh McCloskey), a music student in Rome, urging him to visit her. Using clues provided in Varelli's book as a guide, Rose searches the cellar of her building and discovers a hole in the floor which leads to a water-filled ballroom. After accidentally dropping her keys into the water, she enters the flooded room. Swimming under the surface, she sees a portrait bearing the words \"Mater Tenebrarum\" and is able to reclaim the keys. A putrid corpse suddenly rises from the depths, frightening her. She escapes, although a shadowy figure watches her leave the basement.In Rome, Mark attempts to read Rose's letter during class. He is distracted by the intense gaze of a beautiful student (Ania Pieroni). When the class ends she leaves suddenly; Mark follows, leaving the letter behind. His friend Sara (Eleonora Giorgi) picks up the letter, and eventually reads it. Horrified by the letter's contents, she takes a taxi to a library and locates a copy of The Three Mothers. While looking for an exit, Sara is attacked by a monstrous figure who recognizes the book. She throws the book to the ground and escapes. Later that night, she seeks the company of a neighbor named Carlo (Gabriele Lavia) and both are stabbed to death by a gloved killer. Mark discovers the bodies and two torn fragments from Rose's letter. After the police arrive, he walks out of Sara's apartment and sees a taxi slowly driving by. In it is the music student, staring at him intently once again.Mark telephones Rose but is unable to hear her clearly. He promises to visit just before the connection fails. Cut off, Rose sees two shadowy figures preparing to enter her apartment. She leaves through a back door, but is followed. In a decrepit room, she is grabbed from behind by a clawed assailant and brutally murdered.Upon arriving in New York, Mark meets some of the residents of Rose's building, including a nurse (Veronica Lazar) who is caring for the elderly Professor Arnold (Feodor Chaliapin, Jr.), a wheelchair-bound mute. Mark learns from the sickly Countess Elise (Daria Nicolodi) that Rose has disappeared. Elise explains how Rose had been acting strangely. After the two find blood on the carpet outside Rose's room, Mark follows the stains. He suddenly becomes ill and falls unconscious. Elise sees a black-robed figure dragging Mark away, but the figure suddenly stops and gives chase to Elise. She is attacked by dozens of cats, who bite and claw at her flesh. The hooded figure then stabs her to death. Mark staggers to the house's foyer where the nurse and caretaker (Alida Valli) put him to bed.The next day, Mark asks Kazanian (Sacha Pitoeff), the antique dealer who sold Rose the Three Mothers book, about Rose. However, the man provides no information. That night, Kazanian drowns several cats in a Central Park pond and accidentally falls into the water. Hundreds of rats from a nearby drain crawl all over him, gnawing his flesh. A hot dog vendor hears Kazanian's cries and rushes over. The man kills Kazanian with a knife.Carol, the caretaker, discovers the horribly mutilated corpse of Elise's butler (Leopoldo Mastelloni) in the Countess' apartment. Shocked, she drops a lit candle which starts a fire. Attempting to put out the flames, she becomes entangled in burning draperies and falls from a window to her death.Meanwhile, Mark uses a clue from Rose's letter to discover that beneath each floor is a secret", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}12{"query": "Freshwater below Earths surface is called groundwater. The water infiltrates, or seeps down into, the ground from the surface. How does this happen? And where does the water go? Water infiltrates the ground because soil and rock are porous. Between the grains are pores, or tiny holes. Since water can move through this rock it is permeable. Eventually, the water reaches a layer of rock that is not porous and so is impermeable. Water stops moving downward when it reaches this layer of rock. Look at the diagram in Figure 13.11. It shows two layers of porous rock. The top layer is not saturated; it is not full of water. The next layer is saturated. The water in this layer has nowhere else to go. It cannot seep any deeper into the ground because the rock below it is impermeable. The top of the saturated rock layer in Figure 13.11 is called the water table. The water table isnt like a real table. It doesnt remain firmly in one place. Instead, it rises or falls, depending on how much water seeps down from the surface. The water table is higher when there is a lot of rain and lower when the weather is dry. An underground layer of rock that is saturated with groundwater is called an aquifer. A diagram of an aquifer is shown in Figure 13.12. Aquifers are generally found in porous rock, such as sandstone. Water infiltrates the aquifer from the surface. The water that enters the aquifer is called recharge. Most land areas have aquifers beneath them. Many aquifers are used by people for freshwater. The closer to the surface an aquifer is, the easier it is to get the water. However, an aquifer close to the surface is also more likely to become polluted. Pollutants can seep down through porous rock in recharge water. An aquifer that is used by people may not be recharged as quickly as its water is removed. The water table may lower and the aquifer may even run dry. If this happens, the ground above the aquifer may sink. This is likely to damage any homes or other structures built above the aquifer. One of the biggest aquifers in the world is the Ogallala aquifer. As you can see from Figure 13.13, this aquifer lies beneath parts of eight U.S. states. It covers a total area of 451,000 square kilometers (174,000 square miles). In some places, it is less than a meter deep. In other places, it is hundreds of meters deep. The Ogallala aquifer is an important source of freshwater in the American Midwest. This is a major farming area, and much of the water is used to irrigate crops. The water in this aquifer is being used up ten times faster than it is recharged. If this continues, what might happen to the Ogallala aquifer? The top of an aquifer may be high enough in some places to meet the surface of the ground. This often happens on a slope. The water flows out of the ground and creates a spring. A spring may be just a tiny trickle, or it may be a big gush of water. One of the largest springs in the world is Big Spring in Missouri, seen in Figure 13.14. Water flowing out of the ground at a spring may flow downhill and enter a stream. Thats what happens to the water that flows out of Big Spring in Missouri. If the water from a spring cant flow downhill, it may spread out to form a pond or lake instead. Lake George in New York State, which is pictured in Figure 13.15, is a spring-fed lake. The lake basin was carved by a glacier. Some springs have water that contains minerals. Groundwater dissolves minerals out of the rock as it seeps through the pores. The water in some springs is hot because it is heated by hot magma. Many hot springs are also mineral springs. Thats because hot water can dissolve more minerals than cold water. Grand Prismatic Spring, shown in Figure 13.16, is a hot mineral spring. Dissolved minerals give its water a bright blue color. The edge of the spring is", "pos": "To be a good aquifer, the rock in the aquifer must have good: porosity: small spaces between grains permeability: connections between pores To reach an aquifer, surface water infiltrates downward into the ground through tiny spaces or pores in the rock. The water travels down through the permeable rock until it reaches a layer that does not have pores; this rock is impermeable (Figure 1.1). This impermeable rock layer forms the base of the aquifer. The upper surface where the groundwater reaches is the water table. Groundwater is found beneath the solid surface. Notice that the water table roughly mirrors the slope of the lands surface. A well penetrates the water table. For a groundwater aquifer to contain the same amount of water, the amount of recharge must equal the amount of discharge. What are the likely sources of recharge? What are the likely sources of discharge? What happens to the water table when there is a lot of rainfall? What happens when there is a drought? Although groundwater levels do not rise and fall as rapidly as at the surface, over time the water table will rise during wet periods and fall during droughts. In wet regions, streams are fed by groundwater; the surface of the stream is the top of the water table (Figure 1.2). In dry regions, water seeps down from the stream into the aquifer. These streams are often dry much of the year. Water leaves a groundwater reservoir in streams or springs. People take water from aquifers, too. Groundwater meets the surface in a stream (Figure 1.2) or a spring (Figure 1.3). A spring may be constant, or may only flow at certain times of year. Towns in many locations depend on water from springs. Springs can be an extremely important source of water in locations where surface water is scarce. A well is created by digging or drilling to reach groundwater. It is important for anyone who intends to dig a well to know how deep beneath the surface the water table is. When the water table is close to the surface, wells are a convenient method for extracting water. When the water table is far below the surface, specialized equipment must The top of the stream is the top of the water table. The stream feeds the aquifer. A spring in Croatia bubbles to the surface and feeds the river Cetina. be used to dig a well. Most wells use motorized pumps to bring water to the surface, but some still require people to use a bucket to draw water up (Figure 1.4). An old-fashioned well that uses a bucket drawn up by hand.", "neg": "It's time to be water efficient! As populations increase across Australia and the rest of the world, demand for water will also increase. If we don't reduce each individual's demand for water (both directly and through embodied water) the water situation will become dire. It is obvious that we cannot increase demands for water much more without detrimental effects to the environment, society and the economy. It's all too easy to blame someone else for the water situation -\"if 70% of water is used for agriculture then that's what we should target\" - but it's not that easy. We all depend on the food and resources that agriculture provides, and while there are definitely opportunities to increase water efficiency on the farm, the solution will take more than that. We each share responsibility for the sustainable management of our water resources, which means using less water at home, in the workplace, at school, on holidays, on the farm, ... everyone, everywhere, every time. It's time to become water efficient! This involves reassessing our relationship with water, and learning to use it more sparingly. On the most basic level, it requires a behavioural change, and assigning a value to water that truly reflects its worth. We can also unlock economic benefits of being water efficient. There are many real world examples given in the case studies on this site. Everybody has a responsibility to save water, if future generations are to enjoy a similar standard of living to the one we enjoy now. In fact, many of the impacts associated with water use are likely to have an effect on our own lives! www.savewater.com.au has been designed to help you respond to the challenge to become water efficient. It acts as a central repository for relevant information and further advice, so that you can actually achieve significant savings. It also showcases those companies with products that will assist you in your goal.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}13{"query": "Several properties of the atmosphere change with altitude, but the composition of the natural gases does not. The proportions of gases in the atmosphere are everywhere the same, with one exception. At about 20 km to 40 km above the surface, there is a greater concentration of ozone molecules than in other portions of the atmosphere. This is called the ozone layer. Nitrogen and oxygen together make up 99% of the planets atmosphere. Nitrogen makes up the bulk of the atmosphere, but is not involved in geological or biological processes in its gaseous form. Nitrogen fixing is described in the chapter Life on Earth. Oxygen is extremely important because it is needed by animals for respiration. The rest of the gases are minor components but sometimes are very important (Figure 1.1). Nitrogen and oxygen make up 99% of the atmosphere; carbon dioxide is a very important minor component. Humidity is the amount of water vapor in the air. Humidity varies from place to place and season to season. This fact is obvious if you compare a summer day in Atlanta, Georgia, where humidity is high, with a winter day in Phoenix, Arizona, where humidity is low. When the air is very humid, it feels heavy or sticky. Dry air usually feels more comfortable. When humidity is high, water vapor makes up only about 4% of the atmosphere. Where around the globe is mean atmospheric water vapor higher and where is it lower (Figure 1.2)? Why? Higher humidity is found around the equatorial regions because air temperatures are higher and warm air can hold more moisture than cooler air. Of course, humidity is lower near the polar regions because air temperature is lower. Remember that greenhouse gases trap heat in the atmosphere. Important natural greenhouse gases include carbon dioxide, methane, water vapor, and ozone. CFCs and some other man-made compounds are also greenhouse gases. Some of what is in the atmosphere is not gas. Particles of dust, soil, fecal matter, metals, salt, smoke, ash, and other solids make up a small percentage of the atmosphere and are called particulates. Particles provide starting points (or nuclei) for water vapor to condense on and form raindrops. Some particles are pollutants. Click image to the left or use the URL below. URL:", "pos": "The temperature of the troposphere is highest near the surface of the Earth and decreases with altitude. On average, the temperature gradient of the troposphere is 6.5o C per 1,000 m (3.6o F per 1,000 ft) of altitude. Earths surface is the source of heat for the troposphere. Rock, soil, and water on Earth absorb the Suns light and radiate it back into the atmosphere as heat, so there is more heat near the surface. The temperature is also higher near the surface because gravity pulls in more gases. The greater density of gases causes the temperature to rise. Notice that in the troposphere warmer air is beneath cooler air. This condition is unstable since warm air is less dense than cool air. The warm air near the surface rises and cool air higher in the troposphere sinks, so air in the troposphere does a lot of mixing. This mixing causes the temperature gradient to vary with time and place. The rising and sinking of air in the troposphere means that all of the planets weather takes place in the troposphere. Sometimes there is a temperature inversion, in which air temperature in the troposphere increases with altitude and warm air sits over cold air. Inversions are very stable and may last for several days or even weeks. Inversions form: Over land at night or in winter when the ground is cold. The cold ground cools the air that sits above it, making this low layer of air denser than the air above it. Near the coast, where cold seawater cools the air above it. When that denser air moves inland, it slides beneath the warmer air over the land. Since temperature inversions are stable, they often trap pollutants and produce unhealthy air conditions in cities (Figure 1.1). Smoke makes a temperature inversion visible. The smoke is trapped in cold dense air that lies beneath a cap of warmer air. At the top of the troposphere is a thin layer in which the temperature does not change with height. This means that the cooler, denser air of the troposphere is trapped beneath the warmer, less dense air of the stratosphere. Air from the troposphere and stratosphere rarely mix. Click image to the left or use the URL below. URL:", "neg": "We are lucky to have an atmosphere on Earth. The atmosphere supports life, and is also needed for the water cycle and weather. The gases of the atmosphere even allow us to hear. Most of the atmosphere is nitrogen, but it doesnt do much. Carbon dioxide and oxygen are the gases in the atmosphere that are needed for life. Plants need carbon dioxide for photosynthesis. They use sunlight to change carbon dioxide and water into food. The process releases oxygen. Without photosynthesis, there would be very little oxygen in the air. Other living things depend on plants for food. These organisms need the oxygen plants release to get energy out of the food. Even plants need oxygen for this purpose. The atmosphere protects living things from the Suns most harmful rays. Gases reflect or absorb the strongest rays of sunlight. Figure 15.1 models this role of the atmosphere. Gases in the atmosphere surround Earth like a blanket. They keep the temperature in a range that can support life. The gases keep out some of the Suns scorching heat during the day. At night, they hold the heat close to the surface, so it doesnt radiate out into space. Figure 15.2 shows the role of the atmosphere in the water cycle. Water vapor rises from Earths surface into the atmosphere. As it rises, it cools. The water vapor may then condense into water droplets and form clouds. If enough water droplets collect in clouds they may fall as rain. This how freshwater gets from the atmosphere back to Earths surface. Without the atmosphere, there would be no clouds or rain. In fact, there would be no weather at all. Most weather occurs because the atmosphere heats up more in some places than others. Weather makes life interesting. Weather also causes weathering. Weathering is the slow wearing down of rocks on Earths surface. Wind-blown sand scours rocks like sandpaper. Glaciers of ice scrape across rock surfaces like a file. Even gentle rain may seep into rocks and slowly dissolve them. If the water freezes, it expands. This eventually causes the rocks to crack. Without the atmosphere, none of this weathering would happen. Sound is a form of energy that travels in waves. Sound waves cant travel through empty space, but they can travel through gases. Gases in the air allow us to hear most of the sounds in our world. Because of air, you can hear birds singing, horns tooting, and friends laughing. Without the atmosphere, the world would be a silent, eerie place. Air is easy to forget about. We usually cant see it, taste it, or smell it. We can only feel it when it moves. But air is actually made of molecules of many different gases. It also contains tiny particles of solid matter. Figure 15.3 shows the main gases in air. Nitrogen and oxygen make up 99 percent of air. Argon and carbon dioxide make up much of the rest. These percentages are the same just about everywhere in the atmosphere. Air also includes water vapor. The amount of water vapor varies from place to place. Thats why water vapor isnt included in Figure 15.3. It can make up as much as 4 percent of the air. Ozone is a molecule made of three oxygen atoms. Ozone collects in a layer in the stratosphere. Air includes many tiny particles. The particles may consist of dust, soil, salt, smoke, or ash. Some particles pollute the air and may make it unhealthy to breathe. But having particles in the air is very important. Tiny particles are needed for water vapor to condense on. Without particles, water vapor could not condense. Then clouds could not form and Earth would have no rain. We usually cant sense the air around us unless it is moving. But air has the same basic properties as other matter. For example, air has mass, volume and, of course, density. Density is mass per unit volume. Density is a measure of how closely molecules are packed together. The closer together they are, the greater the density. Since air", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}14{"query": "Al-e Yusefi-ye Sofla (Persian: , also Romanized as Al-e Yusefi-ye Sofla; also known as Al-e Safi-ye Pa'in and Al-e Yusefi-ye Pa'in) is a village in Zirrah Rural District, Sadabad District, Dashtestan County, Bushehr Province, Iran.", "pos": "Siah Sufian (Persian: , also Romanized as Siah Sufian) is a village in Belesbeneh Rural District, Kuchesfahan District, Rasht County, Gilan Province, Iran.", "neg": "La Pannonie is an old village of the Lot region, between Gramat and Rocamadour, situated since the 19th century in the commune of Couzou.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}15{"query": "SAN FRANCISCO--The \"Reading Wizard\", an 11 - year - old - boy, whose offer to read to children without being paid at a local library was refused by libraries, will get to read to younger kids after all. Mayor Willie Brown last Wednesday ordered San Francisco Public Library officials to allow John O'Connor to read to preschool children to get them interested in books and stop them from watching television and video games. \"I didn't expect this kind of attention. \" John said, \"It's just shocking.\" John has chosen his first book, \"The King's Giraffe\", and made up fliers inviting neighborhood children, aged from three to six, to the Presidio Branch every Wednesday afternoon. He planned to call himself the \"Reading Wizard\" and wear a special hat, fake glasses and a black coat. But his idea was refused - on the phone, in person and finally with a letter from Toni Bernardi, the chief of the library's children and youth services. Using terms like \"age appropriate material\" ,she wrote that only library workers are allowed to read to children. John then went to a member of the city board of supervisors , who advised him to write letters to the library officials. \"Our libraries are supposed to turn kids on, not to turn them off.\" Brown said he enjoyed \"the creative idea, the sense of civic duty and the caring for others that John clearly showed us.\"", "pos": "After a discussion last week. \"Do SCHOOL Libraries Need Books?\" the comments from readers included some first-hand views from students. Below are excerpts from their observations on how studying has changed and how they use libraries. It makes little difference whether the books you are reading is electronic or paper. But if you want a place to read, a library is still the place to go. As a kid in school, I often avoid the study hall noises and go to the quiet school library. The library is a place. A learning place. Modern technology won't change the library as long as things are learned. -Scott Being a student I am aware that many of us seldom look at the books in the library unless told to do so by a teacher as a requirement for an assignment. It takes time to find the very book you want at the library, and it may not be necessary to do so. More and more students, such as myself, use the internet for nearly every assignment. There are countless online resources for us to use with a click of the mouse. What's more, books are very expensive and schools could put that money towards charities. -Hayley H I hope schools continue to have libraries. As a student, I know there is a difference between reading something on a screen and something printed. When I read something in a book that I do not understand or want to look further into. I record it and will research later or discuss with someone. With a screen (especially online) I will instantly access the information and look into the question at hand, which interrupts my reading and especially my imagination. -Allie To me, it depends on the purpose of the books. As a student, I prefer to do research online. Online research is faster and more efficient. But when I'm reading for pleasure, I ly refuse to give up a real book. The tactile sensation and freedom that real books give you really makes the reading experience more enjoyable. So my suggestion is that schools have more digital collections for research and scholarly work, and a good selection of interesting and age-appropriate fiction and nonfiction for pleasure reading. -CM", "neg": "Jonathan Shale (Berenger) is a mercenary and a Vietnam veteran who returns home to Miami after a botched covert operation in Cuba in which three men from his platoon were killed. He surprises his girlfriend, Jane Hetzko (Diane Venora) at her apartment and is warmly welcomed. On the outside, Jane is a schoolteacher at inner-city Columbus High School, an institution with a considerable gang problem. She is particularly disliked by Juan Lacas (Anthony), leader of the KOD (\"Kings of Destruction\") gang. While jogging one morning, Jane is attacked and has her leg broken. Jane and Shale believe this to be related to the KOD, which prompts the latter to go undercover as an Ivy League-educated, government-affiliated substitute teacher for his girlfriend's class. Shale arrives at Columbus High School and is, at first, taken back by the lowly conditions. He is unable to control his class of poorly-educated students on the first day, but decides to use his street-smarts and military tactics to gain the upper hand. Soon enough, he is able to take command of the students by displaying his combat self-defence techniques when students attack him. He is warned not to use such methods by Principal Claude Rolle (Hudson), but gains the respect of his students when he bonds with them over the similarities between his early gang and Vietnam War experiences and their involvement in petty crime and street gangs. During this time, he befriends fellow schoolteacher Darrell Sherman (Plummer) and also crosses paths with Lacas, one of his students. Suspicious of odd conditions within the high school, Shale sets up surveillance cameras throughout the building. He discovers that Lacas orchestrated the attack on Jane. He also discovers that Lacas is secretly working with Rolle to distribute cocaine around Miami for a major narcotics ring. Shale and his team raid a drug deal, using the stolen money to buy music and sports equipment in the form of a \"school donation.\" While Sherman initially denies Shale's discovery, Sherman and a female student inadvertently witness the drugs being loaded into one of the school buses later that day. Sherman tells the student to warn Shale and Hetzko, and sacrifices himself by creating a distraction. Rolle, who at this point is aware of Shale's interference orders a \"car accident\" for Shale, and sends Lacas after Hetzko. With the help of another student, Lacas is killed and Shale saves Hetzko, learning the full story from the female witness. Shale and his team garrison the school grounds to enter combat against the remaining K.O.D. members, a rival mercenary company led by Janus, and Rolle himself. Ultimately, Shale and Joey Six end up as the sole survivors of the battle, walking away from the school grounds discussing future operations as substitute teachers.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}16{"query": "Cotinguiba Esporte Clube play their home games at Estadio Lourival Baptista, nicknamed Batistao.", "pos": "Esporte Clube Corinthians played their home games at Estadio Eduardo Jose Farah, nicknamed Farahzao.", "neg": "Wouter Claes (born 28 October 1975 in Leuven, Belgium) is a male left-handed Belgian badminton player.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}17{"query": "More than 500 unrelated patients with neurofibromatosis type 1 (NF1) were screened for mutations in the NF1 gene. For each patient, the whole coding sequence and all splice sites were studied for aberrations, either by the protein truncation test (PTT), temperature-gradient gel electrophoresis (TGGE) of genomic PCR products, or, most often, by direct genomic sequencing (DGS) of all individual exons. A total of 301 sequence variants, including 278 bona fide pathogenic mutations, were identified. As many as 216 or 183 of the genuine mutations, comprising 179 or 161 different ones, can be considered novel when compared to the recent findings of Upadhyaya and Cooper, or to the NNFF mutation database. Mutation-detection efficiencies of the various screening methods were similar: 47.1% for PTT, 53.7% for TGGE, and 54.9% for DGS. Some 224 mutations (80.2%) yielded directly or indirectly premature termination codons. These mutations showed even distribution over the whole gene from exon 1 to exon 47. Of all sequence variants determined in our study, <20% represent C-->T or G-->A transitions within a CpG dinucleotide, and only six different mutations also occur in NF1 pseudogenes, with five being typical C-->T transitions in a CpG. Thus, neither frequent deamination of 5-methylcytosines nor interchromosomal gene conversion may account for the high mutation rate of the NF1 gene. As opposed to the truncating mutations, the 28 (10.1%) missense or single-amino-acid-deletion mutations identified clustered in two distinct regions, the GAP-related domain (GRD) and an upstream gene segment comprising exons 11-17. The latter forms a so-called cysteine/serine-rich domain with three cysteine pairs suggestive of ATP binding, as well as three potential cAMP-dependent protein kinase (PKA) recognition sites obviously phosphorylated by PKA. Coincidence of mutated amino acids and those conserved between human and Drosophila strongly suggest significant functional relevance of this region, with major roles played by exons 12a and 15 and part of exon 16.", "pos": "Neurofibromatosis type 1 (NF1) is an autosomal dominant genetic disorder affecting one in 3,500 individuals. The mutation rate in the NF1 gene is one of the highest known for human genes. Compared to other methods, the protein truncation test (PTT) provides improved efficiency in detecting NF1 mutations which are dispersed throughout the gene which spans 350 kilobases of genomic DNA. We have applied the PTT and subsequent sequence analysis of cloned cDNA to identify mutations in NF1 patients. We report here the identification of two novel (W336X and Q315X), and one recurrent (R304X) mutation located in exon 7 and show that all three premature termination codons lead to skipping of exon 7 in a proportion of the transcripts derived from the mutated allele. Possible mutation-induced alterations of the RNA secondary structure and their impact on skipping of exon 7 of the NF1 gene are explored and discussed.", "neg": "The performance of two proteomic sample preparation methods, \"pseudoshotgun\" (PSG) and filter-aided sample preparation (FASP) were compared in terms of the number of identified proteins, representation of cellular component GO (gene ontology) categories in the obtained list of proteins, and the efficiency of both methods in the proteomic analysis of a very low number of cells. Both methods were combined to obtain a proteomic profile of a short-term culture (passage 3) of melanoma cells, established in our laboratory from a human metastatic melanoma lesion. The data revealed that with FASP, usually more proteins are identified than with PSG when analyzing a higher number of cells ( 5000/injection), whereas PSG is favorable when analyzing only a very small amount of cells (250-500/injection). PSG and FASP, however, are complementary techniques, as combining both methods further increases the number of identified proteins. Moreover, we show that it is feasible to identify a substantial number of proteins from only 250 cells/injection that is equivalent to 60 ng of protein.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}18{"query": "For the first time in franchise history, the Cowboys wore white pants and navy jerseys. The jerseys are usually paired with silver pants. The white pants were the Color Rush pants with a navy/silver/navy stripe down the side, and the navy jersey is the regular alternate navy jersey, usually worn on Thanksgiving. The Cowboys outscored the Giants to win 30-17 and improve to 7-6 and 2-3 without Elliott. Despite the win against the Giants, the eventual Super Bowl champion Philadelphia Eagles clinched the NFC East title with the win against the Rams.", "pos": "Coming off their bye week, the Buccaneers were still looking for their first win of the season. The Bucs traveled to the Louisiana Superdome for their third divisional match-up in a rowthis time, against the New Orleans Saints. The Bucs scored first as rookie QB Bruce Gradkowski threw an 18-yard TD pass to WR Joey Galloway in the first quarter; the Saints responded with a 21-yard field goal from kicker John Carney. The Saints continued scoring, with a 24-yard TD run from RB Deuce McAllister in the second quarter, and a 9-yard TD pass to TE Ernie Conwell in the third quarter. The Bucs finally responded with a 1-yard TD run from FB Mike Alstott, and took the lead in the fourth quarter with Gradkowski's 3-yard TD pass to TE Alex Smith. Unfortunately for the Bucs, a special teams breakdown led to Saints RB Reggie Bush getting his inaugural NFL touchdown on a 65-yard punt return, which sealed the win for the Saints.", "neg": "This game is well known for an infamous penalty that occurred during the overtime period. The Jets were lining up for a game winning 56-yard field goal in overtime to try and give them the win. Nick folk kicked the ball, but the kick went wide right and the Patriots appeared to be taking over with a chance to win. However, Chris Jones of New England was called for a controversial unsportsmanlike conduct penalty after pushing his teammate into the offensive line. This penalty would later be named \"leaping\". The penalty gave the Jets another chance and made the field goal attempt a 51-yard attempt. This time, Folk drilled the kick, and the Jets would go on to stun the Patriots. With the win, the Jets improved to 4-3.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}19{"query": "Allelic polymorphism of the apolipoprotein E (ApoE) gene (ApoE 2, ApoE 3 and ApoE 4 alleles) gives rise to three protein isoforms (ApoE2, ApoE3 and ApoE4) that differ by 1 or 2 amino acids. Inheritance of the ApoE 4 allele is a risk factor for developing Alzheimer's disease (AD). The potential diagnostic value of ApoE protein levels in biological fluids (i.e. cerebrospinal fluid, plasma and serum) for distinguishing between AD patients and healthy elderly subjects is subject to great controversy. Although a recent study reported subnormal total ApoE and ApoE4 levels in the plasma of AD patients, other studies have found normal or even elevated protein levels (versus controls). Because all previously reported assays were based on immunoenzymatic techniques, we decided to develop an orthogonal assay based on targeted mass spectrometry by tracking (i) a proteotypic peptide common to all ApoE isoforms and (ii) a peptide that is specific for the 4 allele. After trypsin digestion, the ApoE4-specific peptide contains an oxidation-prone methionine residue. The endogenous methionine oxidation level was evaluated in a small cohort (n=68) of heterozygous 34 carriers containing both healthy controls and AD patients. As expected, the proportion of oxidized residues varied from 0 to 10%, with an average of 5%. We therefore developed a standardized strategy for the unbiased, absolute quantification of ApoE4, based on performic acid oxidization of methionine. Once the sample workflow had been thoroughly validated, it was applied to the concomitant quantification of total ApoE and ApoE4 isoform in a large case-control study (n=669). The final measurements were consistent with most previously reported ApoE concentration values and confirm the influence of the different alleles on the protein expression level. Our results illustrate (i) the reliability of selected reaction monitoring-based assays and (ii) the value of the oxidization step for unbiased monitoring of methionine-containing proteotypic peptides. Furthermore, a statistical analysis indicated that neither total ApoE and ApoE4 levels nor the ApoE/ApoE4 ratio correlated with the diagnosis of AD. These findings reinforce the conclusions of previous studies in which plasma ApoE levels had no obvious clinical significance.", "pos": "Human apolipoprotein E (apoE) is a 299-amino-acid protein with a molecular weight of 34 kDa. The difference between the apoE3 and apoE4 isoforms is a single residue substitution involving a Cys-Arg replacement at residue 112. ApoE4 is positively associated with atherosclerosis and late-onset and sporadic Alzheimer's disease (AD). ApoE4 and its C-terminal truncated fragments have been found in the senile plaques and neurofibrillary tangles in the brain of AD patients. However, detail structural information regarding isoform and domain interaction remains poorly understood. We prepared full-length, N-, and C-terminal truncated apoE3 and apoE4 proteins and studied their structural variation. Sedimentation velocity and continuous size distribution analysis using analytical ultracentrifugation revealed apoE3(72-299) as consisting of a major species with a sedimentation coefficient of 5.9. ApoE4(72-299) showed a wider and more complicated species distribution. Both apoE3 and E4 N-terminal domain (1-191) existed with monomers as the major component together with some tetramer. The oligomerization and aggregation of apoE protein increased when the C-terminal domain (192-271) was incorporated. The structural influence of the C-terminal domain on apoE is to assist self-association with no significant isoform preference. Circular dichroism and fluorescence studies demonstrated that apoE4(72-299) possessed a more alpha-helical structure with more hydrophobic residue exposure. The structural variation of the N-terminal truncated apoE3 and apoE4 protein provides useful information that helps to explain the greater aggregation of the apoE4 isoform and thus has implication for the involvement of apoE4 in AD.", "neg": "ATP13A2 (PARK9) loss of function mutations are a genetic cause of an early-onset form of Parkinson's disease (PD), with in vitro studies showing that ATP13A2 deficits lead to lysosomal and mitochondrial dysfunction and -synuclein accumulation, while elevated ATP13A2 expression reduces -synuclein toxicity. The three human brain tissue studies assessing changes in ATP13A2 expression in PD produced divergent results; mRNA is increased while protein levels were observed to be either increased or decreased. This apparent conflict in protein levels might have arisen from examining Lewy body disease cases with coexisting Alzheimer-type pathologies.To assess whether ATP13A2 levels in Lewy body disease are modified by Alzheimer-type -amyloid deposition, we evaluated cases of pure PD and pure dementia with Lewy bodies (DLB) for changes in ATP13A2, -synuclein and -amyloid protein levels in cortical regions with and without Lewy bodies. In all Lewy body disease cases, we identified decreased ATP13A2 protein levels that correlated with increases in both -synuclein and -amyloid. Partial colocalization was observed between ATP13A2 and -synuclein in Lewy bodies, whereas ATP13A2 did not colocalize with pathological -amyloid deposition. Our data show that patients with Lewy body diseases have an overall deficit in ATP13A2 protein levels, with the remaining protein being more insoluble and partially redistributing towards Lewy bodies. This supports the concept that increasing ATP13A2 levels may offer potential therapeutic benefits to patients with Lewy body diseases.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}20{"query": "The Bank Job is a 2008 British crime film written by Dick Clement and Ian La Frenais, directed by Roger Donaldson, and starring Jason Statham, based on the 1971 Baker Street robbery in central London, from which the money and valuables stolen were never recovered.", "pos": "Police Story 2 (Chinese: , aka Jackie Chan's Police Story 2) is a 1988 Hong Kong action film written, directed by and starring Jackie Chan as Chan Ka-kui.", "neg": "Paris, 1966...Monsieur Charles Bonnet (Hugh Griffin), the current head of the Bonnet family, custodian of the family's legendary collection of fine art, and a noted collector in his own right, is offering one of his prized paintings at auction. A Cezanne, it sells for a fabulous $515,000, the high point of the auction. When Bonnet's daughter, Nicole (Audrey Hepburn), hears the news on her car radio on her way home from work, she is shocked...and dismayed. The moment she arrives at their elegant old chateau, she runs upstairs calling her father. In his bedroom on the second floor, she opens the door to an antique wardrobe and steps inside, opens a false panel at the back of the wardrobe and climbs a hidden spiral staircase to her father's secret studio in the attic.Bonnet, it turns out, is a forger of fine art...cheerful and charming, but an unrepentant scoundrel. He is putting the finishing touches on his latest project, a flawless rendition of a famous lost Van Gogh. He has even found another painting from the same period, by an unknown artist, and has brushed dirt from the back of that canvas to transfer to his forgery. \"I doubt if even Van Gogh himself would have gone to such pains with his work,\" he boasts. \"He didn't have to, Papa,\" Nicole retorts, \"he WAS Van Gogh!\" She tells him in a tired voice (for what must surely be the thousandth time) that it's a crime to sell fake masterpieces. He replies that he only sells them to wealthy, private buyers, who get an undeniably fine painting in return.A noise in the driveway sends them both to the window: An armored car, a police van, a black limousine and half a dozen motorcycles have arrived and parked in front of the house. Nicole is terrified that the authorities have at last discovered Bonnet's hobby, but Bonnet explains that he has simply agreed to let the Claver-Lafayette Museum display their exquisite statuette of Venus, purportedly carved by 16th Century sculptor Benvenuto Cellini, in their latest exhibit. Nicole is not reassured: Their Cellini Venus is also a forgery...carved at the end of the 19th century by Bonnet's father, using Bonnet's mother as a model. Unlike paintings, she tells her father, it's an easy matter to detect forged sculptures. Bonnet brushes aside her concerns: since he's merely lending the statue, not selling it, there will be no reason to test its authenticity.He runs downstairs (followed closely by Nicole) to greet Monsieur Grammont (Ferdinand Gravey), the museum director, who is here with his assistants and an armed escort to transport the Venus. Bonnet shows him into the library, where the Venus stands in solitary splendor in its own special niche. Grammont is moved almost to tears by the sight of it...he congratulates Bonnet for keeping this fine piece in France, though he must have had many lucrative offers to buy it. Bonnet smiles modestly, and says, \"Well, after all, one is still a Frenchman.\" The Venus is handed over, secured in a heavily padded case, Grammont thanks Bonnet effusively and leaves. Bonnet is jubilant, but Nicole is still worried. He waves off her concern, saying that her basic trouble is that she's honest....\"but I don't tell you that to hurt your feelings,\" he adds kindly. \"I get dizzy spells when we have these conversations, Papa,\" she complains. He invites her to attend the gala opening at the museum that night...she firmly declines.The Cellini Venus is the star of the exhibit, and Bonnet the most celebrated guest at the gala. Davis Leland (Eli Wallach), a wealthy American industrialist, is also present. He has recently taken up art collecting, and is pursuing it as obssessively as he pursued the acquisition of his millions. He is so taken with the Venus that he determines to find out all about Bonnet and his family...with the goal of somehow acquiring the Venus.The Bonnet chateau", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}21{"query": "Derrick Jensen is a prominent member of the Deep Green Resistance Advisory Board.", "pos": "In February 2009, James L. Jones, then-chairman of the Atlantic Council, stepped down in order to serve as President Obama's new National Security Advisor and was succeeded by Senator Chuck Hagel.", "neg": "Jan Muhlstein (born 3 July 1949 in Most, Czechoslovakia) is a journalist, German Jewish activist and the former chair of the Union of Progressive Jews in Germany.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}22{"query": "Colonel Richard Hamilton Rawson, DL, JP (21 February 1863 - 11 October 1918) was a British Army officer and later a Conservative Party and National Party politician.", "pos": "Richard Donnevert (born 2 August 1896 in Mainz - died 27 January 1970 in Wiesbaden) was a German Nazi Party politician.", "neg": "Sir William Bowyer-Smijth, 11th Baronet, DL, JP (22 April 1814 -- 20 November 1883) was a British cricketer, baronet and Conservative Party politician.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}23{"query": "In week 4, the Lions traveled across Lake Michigan to Green Bay, Wisconsin to play division rivals the Green Bay Packers. The Packers started the scoring in the first quarter with a 29-yard TD catch by Donald Driver from Aaron Rodgers. The Lions tied it up in the second quarter with a 23-yard TD catch by Calvin Johnson. The Packers took the lead with a 13-yard catch by Jermichael Finley. They added to their lead 17-yard catch by Greg Jennings. The Lions responded just before halftime with a 21-yard catch by Calvin Johnson. Just after the break, the Packers' Charles Woodson returned an interception for a touchdown. The Lions attempted a comeback with 4 consecutive field goals: from 39 yards and 52 yards in the 3rd quarter, and later from 49 yards and 24 yards in the 4th. With the loss, not only did the Lions fall to 0-4, but it also marked their 19th consecutive loss in Wisconsin.", "pos": "Coming off their Thanksgiving win over their divisional foe, the Lions, the Packers flew to Texas Stadium for a Week 13 Thursday night intraconference duel with the throwback-clad Dallas Cowboys. This match-up would see two 10-1 teams face one another for the first time since 1990 when the New York Giants lost to the San Francisco 49ers. Cowboys quarterback Tony Romo faced off against his boyhood idol Brett Favre in the game. The Packers started the game missing two key players of their defense, with injured cornerback Charles Woodson (tied for 7th in the NFL with 4 interceptions) and pass-rushing end Kabeer Gbaja-Biamila (tied for 6th in the NFL with 9.5 sacks) on the inactive list. In the first quarter, Green Bay took the early lead as rookie kicker Mason Crosby completed a 47-yard field goal. On the first play of the Cowboys opening drive, Al Harris stripped the ball from Terrell Owens and side judge Laird Hayes signaled Green Bay ball, but head linesman Derick Bowers overruled him. The only option for Mike McCarthy to challenge on the play, since the whistle was blown, was whether it was a reception - the strip could not be reviewed. The replay upheld the reception and Dallas retained possession. Nick Folk completed a 26-yard field goal to tie the game. Folk also completed a 51-yard field goal, and QB Tony Romo threw a 3-yard TD pass to WR Patrick Crayton. The Packers would end the first quarter with rookie RB Ryan Grant running for a 62-yard touchdown. In the second quarter, Dallas responded with Romo completing a 26-yard TD pass to TE Anthony Fasano and a 10-yard TD pass to WR Terrell Owens. Brett Favre left the game in the second quarter after he hit his right elbow on the helmet of a blitzing Cowboys DB Nate Jones. The throw led to Favre's second interception. Packers quarterback Aaron Rodgers took over for the Packers next series and led the offense on a 74-yard drive, capping it off with an 11-yard TD pass to WR Greg Jennings. In the third, Grant finished off a 69-yard Packer drive with a 1-yard TD run for the only score of the quarter. In the fourth quarter, Romo completed a 4-yard TD pass to Crayton. Mason Crosby kicked a 52-yard field goal with just over 5minutes remaining in the game to pull the Packers within a field goal. Dallas sealed the win as Folk kicked a 25-yard field goal with 1:03 left in the game. The Packers were flagged for a season-high 142 penalty yards.", "neg": "Coming off a bye week, the Bears battled rival Detroit Lions on Monday Night Football. The team kept the Lions from scoring until the fourth quarter, and forced four takeaways. The first turnover forced was in the first half, when Lance Briggs stripped the ball from Mikel Leshoure, which was recovered by Julius Peppers. The second and third turnovers were forced in the third quarter on Zack Bowman's muffed punt recovery, and Brian Urlacher recovering Joique Bell's fumble. The final turnover occurred when Lions quarterback Matthew Stafford's pass was intercepted by D. J. Moore. The Bears struck first on Jay Cutler's touchdown pass to Brandon Marshall, and Robbie Gould kicked a field goal to increase the first half score to 10-0. During the game, Lions defensive tackle Ndamukong Suh threw Cutler to the ground, injuring his ribs. Cutler was eventually replaced by Jason Campbell for a play, before returning to the game. In the second half, Gould kicked another field goal, and prevented the Lions from scoring until the final 36 seconds of the game, when Stafford threw a 12-yard touchdown pass to Ryan Broyles to narrow the margin to six points, but the Bears sealed the victory by recovering the ensuring onside kick.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}24{"query": "Not everyone had the same warning the people on Tillys beach had. The Boxing Day Tsunami of December 26, 2004 was by far the deadliest of all time (Figure 1.1). The tsunami was caused by the 2004 Indian Ocean Earthquake. With a magnitude of 9.2, it was the second largest earthquake ever recorded. The extreme movement of the crust displaced trillions of tons of water along the entire length of the rupture. Several tsunami waves were created with about 30 minutes between the peaks of each one. The waves that struck nearby Sumatra 15 minutes after the quake reached more than 10 meters (33 feet) in height. The size of the waves decreased with distance from the earthquake and were about 4 meters (13 feet) high in Somalia. The tsunami did so much damage because it traveled throughout the Indian Ocean. About 230,000 people died in eight countries. There were fatalities even as far away as South Africa, nearly 8,000 kilometers (5,000 miles) from the earthquake epicenter. More than 1.2 million people lost their homes and many more lost their ways of making a living. The countries that were most affected by the 2004 Boxing Day tsunami. The Japanese received a one-two punch in March 2011. The 2011 Tohoku earthquake offshore was a magnitude 9.0 and damage from the quake was extensive. People didnt have time to recover before massive tsunami waves hit the island nation. As seen in Figure 1.2, waves in some regions topped 9 meters (27 feet). The tsunami did much more damage than the massive earthquake (Figure 1.3). Worst was the damage done to nuclear power plants along the northeastern coast. Eleven reactors were automatically shut down. Power and backup power were lost at the Fukushima plant, leading to equipment failures, meltdowns, and the release of radioactive materials. Control and cleanup of the disabled plants will go on for many years. As a result of the 2004 tsunami, an Indian Ocean warning system was put into operation in June 2006. Prior to 2004, no one had thought a large tsunami was possible in the Indian Ocean. In comparison, a warning system has been in effect around the Pacific Ocean for more than 50 years. The system was used to warn of possible tsunami waves after the Tohoku earthquake, but most were too close to the quake to get to high ground in time. Further away, people were evacuated along many Pacific coastlines, but the waves were not that large.", "pos": "Tsunami are deadly ocean waves from the sharp jolt of an undersea earthquake. Less frequently, these waves can be generated by other shocks to the sea, like a meteorite impact. Fortunately, few undersea earthquakes, and even fewer meteorite impacts, generate tsunami. Tsunami waves have small wave heights relative to their long wavelengths, so they are usually unnoticed at sea. When traveling up a slope onto a shoreline, the wave is pushed upward. As with wind waves, the speed of the bottom of the wave is slowed by friction. This causes the wavelength to decrease and the wave to become unstable. These factors can create an enormous and deadly wave. Landslides, meteorite impacts, or any other jolt to ocean water may form a tsunami. Tsunami can travel at speeds of 800 kilometers per hour (500 miles per hour). Since tsunami are long-wavelength waves, a long time can pass between crests or troughs. Any part of the wave can make landfall first. In 1755 in Lisbon, Portugal, a tsunami trough hit land first. A large offshore earthquake did a great deal of damage on land. People rushed out to the open space of the shore. Once there, they discovered that the water was flowing seaward fast and some of them went out to observe. What do you think happened next? The people on the open beach drowned when the crest of the wave came up the beach. Large tsunami in the Indian Ocean and more recently Japan have killed hundreds of thousands of people in recent years. The west coast is vulnerable to tsunami since it sits on the Pacific Ring of Fire. Scientists are trying to learn everything they can about predicting tsunamis before a massive one strikes a little closer to home. Although most places around the Indian Ocean did not have warning systems in 2005, there is a tsunami warning system in that region now. Tsunami warning systems have been placed in most locations where tsunami are possible. Click image to the left or use the URL below. URL:", "neg": "After the 2004 Asian tsunami disaster, four independent volunteers, with little money and no experience, race off to volunteer in tsunami ravaged Sri Lanka. They meet up by fate at the Colombo airport and form a volunteer team. They rent a van, fill it with supplies and start driving down the coast to see where they can help. They stumble into a tribal village called Peraliya, which has been destroyed by a forty foot wave. During the time the wave hit Peraliya, a train called \"The Queen of the Sea\" was passing by and was washed away killing over 2500 passengers and villagers. The Four volunteers set up a first aid station and found themselves in charge of running a refugee camp with over 3000 people. Their initial two week journey turns into a year long odyssey of heartbreak and hope as the villagers turn against them when donated tsunami relief money does not materialize. The volunteers concentrate on the bigger picture and break every rule in the 'Disaster Aid Books'.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}25{"query": "Coming off their home win over the Lions, the 49ers flew to the Louisiana Superdome for a Week 4 duel with the New Orleans Saints. In the first quarter, the Niners struck first as kicker Joe Nedney got a 47-yard field goal. In the second quarter, the Saints took the lead with QB Drew Brees completing a 5-yard and a 33-yard TD pass to WR Lance Moore. San Francisco would answer with Nedney's 49-yard field goal, yet New Orleans replied with Brees' 47-yard TD pass to WR Robert Meachem. In the third quarter, the 49ers tried to rally as Nedney kicked a 38-yard field goal. However, in the fourth quarter, the Saints continued to pull away as RB Deuce McAllister got a 1-yard TD run. The Niners tried to rally as QB J.T. O'Sullivan completed a 5-yard TD pass to WR Isaac Bruce, yet New Orleans sealed the win with kicker Martin Gramatica nailing a 31-yard field goal.", "pos": "Coming off their divisional road win over the Rams, the Cardinals went home for a Week 10 NFC West rematch with the San Francisco 49ers on Monday Night Football. In the first quarter, Arizona trailed early as 49ers CB Allen Rossum returned the game's opening kickoff 104 yards for a touchdown. The Cardinals would respond as kicker Neil Rackers got a 28-yard field goal. In the second quarter, San Francisco added onto their lead as QB Shaun Hill completed a 31-yard TD pass to WR Josh Morgan. The Cardinals would answer with QB Kurt Warner completing a 13-yard TD pass to WR Anquan Boldin, along with Rackers getting a 33-yard field goal. The 49ers would close out the half with Hill completing an 18-yard TD pass to TE Vernon Davis. In the third quarter, Arizona crept closer again as Warner completed a five-yard TD pass to WR Larry Fitzgerald, yet San Francisco replied with kicker Joe Nedney getting a 41-yard field goal. In the fourth quarter, the Cardinals took the lead as Rackers nailed a 23-yard field goal, along with Warner hooking up with Boldin again on a five-yard TD pass (with a failed two-point conversion.) The 49ers would mount a late comeback drive, but Arizona made a successful goal-line stand as time ran out.", "neg": "Coming off their road win over the Packers, the Falcons went home for a Week 6 duel with the Chicago Bears. In the first quarter, Atlanta took flight as kicker Jason Elam got a 29-yard and a 48-yard field goal. In the second quarter, the Falcons increased their lead as Elam kicked a 32-yard field goal. The Bears would respond with kicker Robbie Gould getting a 36-yard field goal.Entering Sunday game with the Bears, the Falcons led the NFL in first quarter scoring with 48 points. After posting two field goals for a 6-0 lead following the first 15 minutes of play against Chicago, Atlanta has now outscored its opponent in the first quarter by a 54-14 margin. A chance at a touchdown came with 9:16 remaining in the first half after a curious turn of events near the goal line. A third-down run by Jerious Norwood came up short and ended with a fumble. Bears defensive tackle Tommie Harris recovered but lost the ball before he was touched down. Jason Snelling recovered the ball for the Falcons, who got a fresh set of downs. Following the first half of play, the Falcons defense held the Bears to 20 first half rushing yards. The 20 yards are the fewest given up in the first half of a game by Atlanta's defense since October 1, 2006, against Arizona (two yards). In the third quarter, the Falcons continued to add onto their lead as Elam got a 41-yard field goal, yet Chicago answered with RB Matt Forte getting a 3-yard TD run. In the fourth quarter, Atlanta replied with rookie quarterback Matt Ryan completing a 3-yard TD pass to WR Roddy White. Defensive end Jamaal Anderson paced a defense that fed off the crowd's energy. He finished with four tackles (two for loss) and the first sack of his two-year career. Anderson also had two pass deflections on the Bears' first drive of the second quarter.The Falcons offense started the second half with a no-huddle offense and added another Elam field goal to take a 12-3 lead. Chicago stuck with the running game and added a touchdown from Forte with 2:24 remaining in the third quarter. Chicago drove within inches of the end zone, but Matt Forte was stuffed on fourth down as he attempted to leap across the line. Michael Boley came in low to trip up the runner, then Lawyer Milloy and Keith Brooking finished him off.The Bears took the lead with Gould getting a 32-yard field goal, along with quarterback Kyle Orton completing a 17-yard TD pass to WR Rashied Davis. Fortunately, the Falcons got the last laugh as Elam nailed the game-winning 48-yard field goal.The 16-year veteran's celebration was interrupted by a swarm of teammates near midfield. It was his fifth successful kick of the day but just moments before he missed a kick that could have iced the game. Chicago came off the miscue with a 77-yard touchdown drive to take a 20-19 lead with 11 seconds to play. But a 9-yard return off a short kickoff by Harry Douglas and a 26-yard strike from rookie quarterback Matt Ryan to Michael Jenkins set Elam up for the game-winner with 1 second left. \"I'm really happy that one went through\", Elam said. \"Our guys have been fighting so hard for so long. I hate to even mention what happened last year but to hear some of the stories I know the guys are really hungry to get some wins on the board and show our fans what we're all about.\" With time to throw Ryan thrived. The rookie found five different receivers and performed regular Houdini-like acts to find open players down the field for third-down conversions. Fellow rookie Douglas caught five passes for 96 yards including a 47-yard strike on third down that set up a 3-yard scoring toss to White with 13:25 remaining.Ryan opened the game 8-of-8 for 107 yards and captained nearly identical scoring drives in the first quarter, leading the team on 48- and 49-yard marches that ended with field goals.\"I think everybody is excited with the win\", Ryan said. \"I thought we played a very good Chicago Bears team today", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}26{"query": "Mutations in the solute carrier family 9, subfamily A member 6 (SLC9A6) gene, encoding the endosomal Na+/H+ exchanger 6 (NHE6) are associated with Christianson syndrome, a syndromic form of X-linked intellectual disability characterized by microcephaly, severe global developmental delay, autistic behavior, early onset seizures and ataxia. In a 7-year-old boy with characteristic clinical and neuroimaging features of Christianson syndrome and epileptic encephalopathy with continuous spikes and waves during sleep, we identified a novel splice site mutation (IVS10-1G>A) in SLC9A6. These findings expand the clinical spectrum of the syndrome and indicate NHE6 dysfunction as a new cause of electrical status epilepticus during slow-wave sleep (ESES).", "pos": "Christianson syndrome (CS) is caused by mutations in SLC9A6 and is characterized by severe intellectual disability, absent speech, microcephaly, ataxia, seizures, and behavioral abnormalities. The clinical phenotypes of CS and Angelman syndrome (AS) are similar. Differentiation between CS and AS is important in terms of genetic counseling. We report on two children with CS and confirmed mutations in SLC9A6 focusing on neuroimaging findings and review the available literature. Cerebellar atrophy (CA) occurs in approximately 60% of the patients with CS and develops after the age of 12 months. Hyperintense signal of the cerebellar cortex (CbC) is less common, and may be diffuse, patchy, or involve only the inferior part of the cerebellum and is best seen on coronal fluid attenuation inversion recovery images. CA and CbC-hyperintensity are not neuroimaging features of AS. In a child with the phenotype of AS, CA and/or CbC-hyperintensity are rather specific for CS and should prioritize sequencing of SLC9A6.", "neg": "FK506 binding protein 6, also known as FKBP6, is a human gene.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}27{"query": "Hip, Hip, Hurrah! (Danish: Hip, hip, hurra! Kunstnerfest pa Skagen) is an oil-on-canvas painting from 1888 by Norwegian-Danish painter Peder Severin Kryer.", "pos": "Company in a courtyard behind a house (1663-1665) is an oil on canvas painting by the Dutch painter Pieter de Hooch, it is an example of Dutch Golden Age painting and is part of the collection of the Amsterdam Museum, on loan to the Rijksmuseum.", "neg": "Maria Schalcken (1645 -- 1699), was a Dutch Golden Age painter, sister and pupil of Godfried Schalcken.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}28{"query": "Hoping to snap a three-game losing streak, the Chiefs went home for a Week 12 Sunday night duel with the Pittsburgh Steelers. Kansas City delivered the game's first punch in the opening quarter with a 41-yard field goal from kicker Ryan Succop. The Steelers would answer in the second quarter with kicker Shaun Suisham getting a 21-yard field goal, followed by quarterback Ben Roethlisberger completing a 2-yard touchdown pass to tight end Weslye Saunders. The Chiefs would reply with a 49-yard field goal from Succop, but Pittsburgh would close out the half with Suisham booting a 49-yard field goal. After a scoreless third quarter, Kansas City began to chip away at their deficit in the fourth quarter with a 40-yard field goal from Succop. However, the Steelers' defense held on to preserve the win.", "pos": "After winning in a close game at home, the Steelers traveled to Cincinnati for Game 2 against the Bengals. The Bengals scored first in the first quarter when Randy Bullock kicked a 35-yard field goal to make it 3-0. They would then make it 10-0 when Andy Dalton found A.J. Green on an 8-yard pass. In the second quarter, Dalton and Green connected again on a 15-yard pass to make it 17-0. The Steelers managed to get on the board before halftime when Chris Boswell put a 30-yard field goal through to make the score 17-3. In the third quarter, the Steelers drew closer when Ben Roethlisberger found Le'Veon Bell on a 35-yard touchdown to make it 17-10. The Bengals moved back ahead by double digits when Randy Bullock kicked a 31-yard field goal to make it 20-10. In the fourth quarter, it was all Steelers when Boswell put up a 37-yard field goal to make it 20-13. Roethlisberger then found Antonio Brown on a 6-yard pass to tie the game up at 20-20. Finally, Boswell was able to seal the victory with a 38-yard field goal to make the final score 23-20. With their sixth straight win over the Bengals, the Steelers improved to 10-2. The victory marks the third time that the Steelers have recorded two different 7+ win streaks within consecutive and separate regular seasons (1975-76, 1994-95). The team also won their 8th straight game against a divisional opponent. With the win, the Steelers began 4-0 in their division for the first time since 2008. The 17-point comeback was the Steelers' largest since they came back from down 17 on December 20, 2015 against the Denver Broncos, and their largest on the road since their 21-point comeback on October 5, 1997 against the Baltimore Ravens.", "neg": "This game is well known for an infamous penalty that occurred during the overtime period. The Jets were lining up for a game winning 56-yard field goal in overtime to try and give them the win. Nick folk kicked the ball, but the kick went wide right and the Patriots appeared to be taking over with a chance to win. However, Chris Jones of New England was called for a controversial unsportsmanlike conduct penalty after pushing his teammate into the offensive line. This penalty would later be named \"leaping\". The penalty gave the Jets another chance and made the field goal attempt a 51-yard attempt. This time, Folk drilled the kick, and the Jets would go on to stun the Patriots. With the win, the Jets improved to 4-3.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}29{"query": "The film opens on October 30, 1988, nearly ten years after Michael Myers's last murderous rampage in Haddonfield, Illinois. An ambulance from Smith's Grove, IL makes its way along the road in a thunderstorm toward the Ridgemont Federal Sanitarium, where Michael, who has been in a coma since then, has been incarcerated. After the apprehensive transfer crew is seen off by medical chief of staff Dr. Hoffman, the ambulance makes its way up the driveway in the storm and back out onto the highway toward Smith's Grove. While in the ambulance, he hears that eight-year-old Jamie Lloyd, his niece and the daughter of Laurie Strode, his first target, is residing in Haddonfield. He immediately grabs and repeatedly bashes a hospital attendant's head against the wall of the ambulance and stabs his finger right into his skull. The other attendant, trapped by the ambulance's locked doors, can only watch helplessly. Soon after, the film introduces Jamie, who has been adopted by the Carruthers family and is still mourning the loss of her mother. Laurie supposedly died in a car accident eleven months earlier. Her older foster sister Rachel comes into her room and consoles her, telling her that she will love her just as much as her mother did. Rachel sends Jamie off to bed and exits the room. Jamie kneels down next to the bed and says her prayers when suddenly, lightning and thunder crash outside, startling her. The door creaks open and as Jamie gets up to close it, the reflection of Michael, donned in his classic white mask and black coveralls, appears in the mirror. Jamie returns to her bed and instantly, Michael's hand reaches out from under the bed and grabs her by the leg. Jamie struggles, gets loose, and runs to her closet. Opening the door, a second Michael appears in front of her, raising his knife. Jamie screams again, attracting the attention of her foster mother, Darlene, who rushes into the room. She finds Jamie, shaking on the floor of her closet, traumatized after what was only a horrific nightmare.Dr. Loomis angrily marches into Hoffman's office the next day, berating him about the transfer of Michael Myers. Hoffman explains that it was mandated by federal law; as he does, he is interrupted by a phone call informing him of an accident involving the ambulance that was carrying Michael Myers. Immediately Loomis smells trouble, and the two men drive to the site of the accident. The state police have secured the scene; the ambulance is upside-down in a river with blood on both the outside & interior. One trooper tells Hoffman it was likely an accident, but Loomis does not believe it. Despite Hoffman's admonishments, Loomis wades into the river & walks round to the ambulance's rear. Inside is a scene of horror; blood is sprayed all over the walls & floor of the ambulance. Immediately, Loomis heads toward Haddonfield, certain that Michael Myers is headed there. Meanwhile, at a gas station, a mechanic works beneath a car, calling for someone to hand him a wrench. When he hears no response, he slides out. There is Michael, raising a long, sharp pole in the air. He thrusts it down into the mechanic's stomach, killing him instantly. Loomis soon after arrives at the gas station and finds the mechanic's body, hanging by a chain from the roof. He also finds several other bodies and immediately sees Michael, standing against the back wall. Loomis shoots at him, but Michael disappears. Loomis scurries out to the exterior of the gas station, barely catching Michael driving away in a truck. Just after, the entire gas station explodes. Loomis survives after crouching behind a nearby barrel.Meanwhile, Jamie is coming home from school to see several kids coming upon her, taunting her that she has no mother. Jamie runs from the scene, crying. At home, Rachel plans to go out for Halloween with her boyfriend, Brady, but her parents refuse and force her to take Jamie trick-or-treating. Rachel protests and Jamie overhears, upset at the fact that Rachel", "pos": "The film opens in 19th century Maryland where several Baltimore policemen are chasing after the screams of a woman in an apartment. The police arrive at the apartment in time only to discover a woman (Jasmina Ilic) sprawled on the floor with her throat sliced open and the corpse of her daughter (Teodora Uveric) stuffed in the chimney. Detective Emmett Fields (Luke Evans) is called to assist in the investigation and discovers that the crime resembles a fictional murder in the short story The Murders in the Rue Morgue, which is part of a collection of stories penned by the writer Edgar Allan Poe (John Cusak).Poe has become a social pariah and penniless drunkard whose stories have not been circulated for some time. He has fallen in love with the beautiful young Emily Hamilton (Alice Eve) and desires to marry her but faces opposition from her father Captain Charles Hamilton (Brendan Gleeson), a military man who loathes Poe and goes to the length of threatening physical violence. Poe is brought to see Fields for questioning and is horrified to learn someone is using his stories as the backdrop for a series of murders. Fields then proposes that Poe volunteer his services to help the police catch the killer and Poe agrees to the task.The two men are called to investigate the murder of literary critic Rufus Griswold (John Warnaby), the man who became Poe's rival after a feud that was published in the Baltimore newspapers. Poe realizes the gruesome crime resembles a scene from The Pit and the Pendulum as Fields notices a red demon mask near the corpse. The two then deduce that the scene of the next crime will take place at Captain Hamilton's annual masquerade ball a scene that will resemble the Masked Ball in The Masque of the Red Death.Fields assigns several members of the Baltimore Police to go undercover as guests at the Masked Ball. Sometime before midnight, at the height of the festivities, a man on horseback dressed in a skeleton costume appears. Fields shoots the man only to learn he was an actor hired for the entertainment and receives an anonymous note. Poe then realizes Emily has been kidnapped, meaning the event was all a distraction. It's revealed in the killer's note that he will continue to commit murders and leave clues to Emily's location. The killer then threatens to kill Emily if Poe does not start writing columns for the newspaper that describe the brutal combination of fact and fiction forcing Poe to comply with the request in order to save Emily.The local Medical School's anatomy class discovers a live raven and the corpse of a prostitute in theatrical clothing. Poe and Fields investigate and deduce the scene resembles The Mystery of Marie Roget except for one detail the blood on the corpse's hands was not an element of Poe's story. The two soon learn the woman was an actress (Ana Sofrenovic) in costume as Lady Macbeth and rush to the theatre where the victim worked, demanding to see all the stage hands. All the stage hands are accounted for except for Maurice Rabichaux (Dejan Cubrilov), a sailor on leave after his ship landed in Baltimore. Poe and Fields notice a mysterious figure running along the catwalks and pursue him but the figure escapes. Fields later makes an off-handed comment that the name of the ship Maurice arrived on is the Fortunato which prompts Poe to realize the next murder will resemble The Cask of Amontillado.Poe and Fields search tunnels under the city with several policemen and discover an area with fresh brickwork, an area that might be where Emily is being held. The officers smash through the brick and discover what appears to be a woman with blonde hair in the costume Emily wore the night she was kidnapped. But the body is revealed to be that of the sailor Maurice, who was dressed to resemble Emily after he was killed and buried in the niche. Two clues are found on Maurice: a pocket watch that was stopped at 12:27 and then stuffed into his mouth, and a tattoo on his back that had some flesh carved out of it. Poe and Fields deduce these clues will give the location of Emily, and Poe realizes a church in Baltimore called Holy Cross is where Emily", "neg": "New Orleans, Louisiana, 1927. An enraged posse of men descend on the isolated Seven Doors Hotel deep in the swamps. They grab an artist called Schweik (Antoine Saint John), who is cloistered there. Accusing him of being a warlock, Schweik is dragged down to the cellar where he is savagely beaten with heavy chains, tortured with quicklime acid, and crucified with his wrists nailed to a cellar wall, despite his dire warnings of evil to be unleashed.New Orleans, 1981. Liza Merril (Catriona MacColl) is a young woman who arrives from New York City to claim the hotel as her inheritance. No sooner has architect friend Marin Avery (Michele Mirabella) begins to show her around the property, strange incidents begin to happen. A painter (Anthony Flees) falls off his rig and is horribly injured, coughing up blood and babbling about, \"the eyes, the eyes.\" Dr. John McCabe (David Warbeck) arrives to take the injured man to the hospital, and offers Liza some sympathy. Next, a plumber, named Joe, attempts to repair a major leak in the flooded cellar. However, he is murdered by a presence that emerged from behind a slim-caked wall. The atmosphere at the hotel is further chilled by the creepy-looking servants, Arthur (Giampaolo Saccarola) and Martha (Veronica Lazar), who apparently come with the hotel. Martha discovers Joe's dead body in the cellar, and another much older cadaver lying in a pool of dirty water nearby. It is apparently that of Schweik, the artist.Driving down the 14-mile causeway to New Orleans, Liza encounters a strange blind woman, standing in the middle of the desolate highway. The blind woman introduces herself as Emily (Sarah Keller), and tells Liza that she has been waiting for her, although her eyes are occluded with cataracts. Liza drives Emily over to her opulently furnished house in New Orleans. Liza is warned by Emily to leave the hotel while she still can. Meanwhile at the hospital morgue, Dr. John McCabe is performing the autopsy on Joe the plumber while his assistant Harris (Al Cliver) wants to install an EMG machine to the corpse of Schweik. John laughs it off and leaves for lunch, while Harris remains behind to install the EMG machine. After Harris leaves for a call, the EMG machine begins pulsing with activity. A little later, Joe's wife Mary-Anne (Laura De Marchi) arrives with her daughter Jill (Maria Pia Marsale) to dress up her husband's corpse for the funeral, when she is killed in a horrific way by scalded with acid. Jill is then menaced by the re-animated cadaver of Schweik.Liza meets with John McCabe in a downtown bar to discuss her misgivings and anxieties. He expresses puzzlement when Lisa complains about he ineptitude of her weird servants. John claims to have never heard of them before despite knowing everyone in the area. Then a phone call from the bar arrives from Harris who informs John that Mary-Anne's body was found in the morgue, while Jill was found huddled in a corner frightened and unable to speak. After Joe and Mary-Anne's funeral, Emily appears again to Liza that evening at the hotel. Emily tells Liza about the warlock Schweik, who stayed in Room 36 of the hotel and about the supernatural underworld that the hotel conceals. The hotel was built over one of the Seven Gates of Hell, and Schweik has been the Guardian. Emily is about to reveal more when her hands wander over to a canvas depicting a desolate vision of lost souls in a terrible and arid landscape. Suddenly afraid, Emily says that the painting was painted by Schweik before he died, and she runs out of the hotel parlor into the night. But Liza notices a disquieting fact about her sudden departure: Emily made no footfalls on the bare wooden boards as she ran, and neither did her seeing-eye dog.The next day, Liza ventures nervously into Room 36, a dingy phantasmal of sheet-covered furniture and shafts of dusty light. She finds an ancient book, whose weirdly flesh-like cover bears the single word", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}30{"query": "Meanwhile, in 1274, the former Dali Kingdom was officially reorganized as the Province of Yunnan, with Sayyid Ajjal Shams al-Din Omar as governor. In May 1275, the governor sent a report to the emperor stating that the embassy had not returned; that the Burmese evidently had no intention of submitting; and that war was the only way forward. But the emperor rejected an outright invasion. Just coming off a disastrous Japanese campaign, the emperor was unwilling to commit the central government troops to what he considered a low priority affair. He was now focused on delivering the final blow against the Song; the emperor ordered the Yunnan provincial army to secure the borderlands in order to block the escape path of the Song refugees. He also sanctioned a limited border war if Pagan contested the takeover. As planned, the Yunnan army proceeded to consolidate the borderlands in 1275-76. Elsewhere, the main Mongol armies had captured most of the Song territory by 1276. By 1277, at least one Burmese vassal state named \"Gold Teeth\" had submitted to the Mongols. Like in 1272, the Burmese government responded by sending an army to reclaim the rebellious state; but unlike in 1272, the Mongols had posted a sizable garrison there. Though it was ultimately under Mongol command, many of the officers and most of the soldiers of the garrison were Turkic-speaking peoples or people from the further west: Turks from Samarkand, Bukhara, Merv and Nishapur, but also captive soldiers from the Persian Khwarazmid empire, the Kipchaks, and even Bulgars from the lower Volga.", "pos": "After the defeat of several Song armies in the north, Emperor Qinzong wanted to negotiate a truce with the Jin, but he committed a massive strategic blunder when he commanded his remaining armies to protect prefectural cities instead of Kaifeng. Neglecting the importance of the capital, he left Kaifeng defended with fewer than 100,000 soldiers. The Song forces were dispersed throughout China, powerless to stop the second Jurchen siege of the city. The Jin assault commenced in mid December 1126. Even as fighting raged on, Qinzong continued to sue for peace, but Jin demands for territory were enormous: they wanted all provinces north of the Yellow River. After more than twenty days of heavy combat against the besieging forces, Song defenses were decimated and the morale of Song soldiers was on the decline. On January 9, 1127, the Jurchens broke through and started to loot the conquered city. Emperor Qinzong tried to appease the victors by offering the remaining wealth of the capital. The royal treasury was emptied and the belongings of the city's residents were seized. The Song emperor offered his unconditional surrender a few days later. Qinzong, the former emperor Huizong, and members of the Song court were captured by the Jurchens as hostages. They were taken north to Huining , where they were stripped of their royal privileges and reduced to commoners. The former emperors were humiliated by their captors. They were mocked with disparaging titles like \"Muddled Virtue\" and \"Double Muddled\". In 1128 the Jin made them perform a ritual meant for war criminals. The harsh treatment of the Song royalty softened after the death of Huizong in 1135. Titles were granted to the deceased monarch, and his son Qinzong was promoted to Duke, a position with a salary.", "neg": "In 1740, the Mon of Lower Burma revolted against the Toungoo Dynasty and founded the Restored Hanthawaddy Kingdom based in Pegu . Throughout the 1740s, the Hanthawaddy forces were winning against Upper Burma-based Toungoo armies. The Siamese were concerned by another rising power in Burma since a strong Burma historically meant future invasions to Siam. Concerned, the Siamese court readily gave protection to the Burmese governors of Martaban and Tavoy who had fled to Siam. In 1745, they sent a diplomatic mission to Ava to evaluate the political situation there, and were received by the Burmese king Mahadhammaraza Dipadi. They saw an Ava court that was on its last legs. By 1751, Restored Hanthawaddy forces were closing in on Ava. The Siamese concerns about the emergence of another strong dynasty based in Pegu appeared imminent. Perhaps as a precautionary measure, the Siamese decided to move their forward base into the upper coast in 1751. While it remains unclear as to whether the Siamese ever intended to go beyond the coast into mainland Lower Burma, the Siamese action nonetheless rang alarm bells in Pegu. Deeply concerned, the Hanthawaddy leadership withdrew two-thirds of their army back down to Lower Burma immediately after they had toppled the last Toungoo king in April 1752. This redeployment of Hanthawaddy troops proved a critical turning point in Burmese history as it gave nascent Upper Burmese resistance groups much needed breathing room. The Hanthawaddy command left less than 10,000 men to pacify all of Upper Burma. Taking advantage of light Hanthawaddy troops, one resistance group, the Konbaung Dynasty led by Alaungpaya, drove out Hanthawaddy troops from Upper Burma by May 1754. Konbaung armies invaded Lower Burma in 1755, and captured Pegu in 1757, ending the 17-year-old Mon kingdom.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}31{"query": "Sir Lionel is the younger son of King Bors of Gaunnes (or Gaul) and Evaine and brother of Bors the Younger in Arthurian legend.", "pos": "Isias was the daughter of King Ariobarzanes I of Cappadocia and his wife Queen Athenais Philostorgos I, while her brother was King Ariobarzanes II of Cappadocia.", "neg": "Sharpe's Challenge is a British TV film from 2006, usually shown in two parts, which is part of an ITV series based on Bernard Cornwell's historical fiction novels about the English soldier Richard Sharpe during the Napoleonic Wars.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}32{"query": "I'm not so sure I like my friends any more. I used to like them-to be honest. We'd have lunch, talk on the phone or exchange emails, and they all seemed normal enough. But then came Face Book, and I was introduced to a sad fact: many of my friends have dark sides that they had kept from me. Today my friends show off the more unpleasant aspects of their personalities via FaceBook. No longer hidden, they're thrown in my face like TV commercials -unavoidable and endless advertisements for the worst of their personalities. Take Fred. If you were to have lunch with him, you'd find him warm, and self-effacing .Read his FaceBook and you'll realize he's an unbearable, food-obsessed boring man. He'd pause to have a cup of coffee on his way to save a drowning man-and then write about it. Take Andy. You won't find a smarter CEO anywhere, but now he's a CEO without a company to run. So he plays Mafia Wars on FaceBook. He's doing well-level 731. Thanks to FaceBook, I know he's playing about 18 hours a day. Andy, you've run four companies-and this is how you spend your downtime? What happned to golf?What happened to getting another job? Take Liz. She is positive that the flu vaccine will kill us all and that we should avoid it. And then comes Chris who likes to post at least 20 times a day on every website he can find, so I get to read his thoughts twice, once on FaceBook and once on Twitter. In real life, I don't see these sides of people. Face to face, my friends show me their best. They're nice, smart people. But face to FaceBook, my friends is like a blind date which goes horribly wrong. I'm left with a dilemma. Who is my real friend?Is it the Liz I have lunch with or the anti-vaccine madman on FaceBook? Is it the Fred I can grab a sandwich with or the Fred who weeps if he's at a party and the wine isn't up to his standard?", "pos": "\"People are ruder today because they are rushed and more 'time poor' than ever before, \" says Patsy Rowe, \" Manners have fallen off the radar . \" Due to our strong attraction to electronic equipment it is a wonder more people don't wake up each morning and greet the singing birds with a complaint about the noise. Here are some examples of rudeness. Some people prefer to do almost everything over the internet. To them, dealing with an actual human is like an evolutionary step backward. It feels very slow because humans don, t work at 4G speeds. When you have dinner with friends, you will often notice someone paying more attention to his mobile phone. We have programmed ourselves to think that every new message brings life-changing news, so taking calls and checking our texts are more important than talking to the people we are with. What is worse, some people even tend to send anonymous rude messages by email. However, rudeness is never acceptable, Don, t assume it is OK to be rude if the person you, re in touch with won, t recognize you. If you have something awful to say, have the courage to face the person and say it, write a letter or email and sign it, or forget it. Upsetting people with unsigned messages is cruel and disgusting. We shouldn't blame technology for our shortcomings. Technology is here to help us, but we should not allow it to take over our lives. An important step is acknowledging our shortcomings. People spend a lot of time pointing out bad manners but it would be even more help if we'd publicly acknowledge good manners when we see them.", "neg": "One of the most recent social changes taking place in the world is social networking. Social networking has been in existence for at least 150 years, and probably longer than that. In the times before the invention of the computer and the World Wide Web (WWW), social networking was done in person. People who had similar likes and interests would gather together to share experiences, make new friends, and improve their businesses. On the Internet, social networking websites made their first appearances during the late 1990s. The first major social networking website in the United States was MySpace. MySpace allowed its users to exchange messages, share pictures, and make new friends in a way that was never thought of in the past. With MySpace, people who did not go out much could reach out to others from their own homes. In 2004, Facebook was created. It was first a website created for use by Harvard University's students and teachers, but it soon expanded to include just about everyone. It is now larger than some of the largest companies in the world. It is a website that is changing all the time. Facebook has completely changed the way people stay connected with each other and the rest of the world. The way it works is simple. Users can set up a new account easily. All a new user needs is an email address to start. Once a person has created an account and his friend also has his own Facebook page, he can invite his friend by sending a request out to him. Once you get started, making new friends will come easily.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}33{"query": "Fotografiska is housed at Stadsgarden, in a former customs house in the Art Nouveau style dating from 1906.", "pos": "The Witte Huis (Dutch pronunciation: (t ys)) or White House is a building and National Heritage Site in Rotterdam, Netherlands, built in 1898 in the Art Nouveau style.", "neg": "This tryptch is missing a panel, lost when it was disassembled in 1777, but the panel with St. Anthony Beaten by Devils is currently on display at the Pinacoteca Nazionale.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}34{"query": "Prelude and Fugue in A minor, BWV 543 is a piece of organ music written by Johann Sebastian Bach sometime around his years as court organist to the Duke of Saxe-Weimar (1708--1717).", "pos": "The Flute sonata in E minor (HWV 379) was composed (circa 1727-28) by George Frideric Handel for flute and keyboard (harpsichord).", "neg": "Josef Barta, also Josef Bartha, (1744 in Prague - 13 June 1787 in Vienna ) was a Czech composer.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}35{"query": "The Sonoma Barracks (El Cuartel de Sonoma) is a two-story, wide-balconied, adobe building facing the central plaza of the City of Sonoma, California.", "pos": "The Eastern Columbia Building, also known as the Eastern Columbia Lofts, is a thirteen-story Claud Beelman designed Art Deco building located at 849 S. Broadway in the Broadway Theater District of Downtown Los Angeles.", "neg": "Intevac, Inc. (NASDAQ: IVAC) is headquartered in Santa Clara, California in the Silicon Valley, with an office in Carlsbad, California as well.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}36{"query": "La Paz F.C. plays its home matches at Estadio Hernando Siles.", "pos": "Cotinguiba Esporte Clube play their home games at Estadio Lourival Baptista, nicknamed Batistao.", "neg": "Weisse Wiese (The White Field), also known as Borussia Sportpark, was the first home stadium of Borussia Dortmund.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}37{"query": "Compelling evidence indicates that the CRISPR-Cas system protects prokaryotes from viruses and other potential genome invaders. This adaptive prokaryotic immune system arises from the clustered regularly interspaced short palindromic repeats (CRISPRs) found in prokaryotic genomes, which harbor short invader-derived sequences, and the CRISPR-associated (Cas) protein-coding genes. Here, we have identified a CRISPR-Cas effector complex that is comprised of small invader-targeting RNAs from the CRISPR loci (termed prokaryotic silencing (psi)RNAs) and the RAMP module (or Cmr) Cas proteins. The psiRNA-Cmr protein complexes cleave complementary target RNAs at a fixed distance from the 3' end of the integral psiRNAs. In Pyrococcus furiosus, psiRNAs occur in two size forms that share a common 5' sequence tag but have distinct 3' ends that direct cleavage of a given target RNA at two distinct sites. Our results indicate that prokaryotes possess a unique RNA silencing system that functions by homology-dependent cleavage of invader RNAs.", "pos": "The CRISPR/Cas system in prokaryotes provides resistance against invading viruses and plasmids. Three distinct stages in the mechanism can be recognized. Initially, fragments of invader DNA are integrated as new spacers into the repetitive CRISPR locus. Subsequently, the CRISPR is transcribed and the transcript is cleaved by a Cas protein within the repeats, generating short RNAs (crRNAs) that contain the spacer sequence. Finally, crRNAs guide the Cas protein machinery to a complementary invader target, either DNA or RNA, resulting in inhibition of virus or plasmid proliferation. In this article, we discuss our current understanding of this fascinating adaptive and heritable defense system, and describe functional similarities and differences with RNAi in eukaryotes.", "neg": "Heme is critical for a variety of cellular processes, but excess intracellular heme may result in oxidative stress and membrane injury. Feline leukemia virus subgroup C receptor (FLVCR1), a member of the SLC49 family of four paralogous genes, is a cell surface heme exporter, essential for erythropoiesis and systemic iron homeostasis. Disruption of FLVCR1 function blocks development of erythroid progenitors, likely due to heme toxicity. Mutations of SLC49A1 encoding FLVCR1 are noted in patients with a rare neurodegenerative disorder: posterior column ataxia with retinitis pigmentosa. FLVCR2 is highly homologous to FLVCR1 and may function as a cellular heme importer. Mutations of SLC49A2 encoding FLVCR2 are observed in Fowler syndrome, a rare proliferative vascular disorder of the brain. The functions of the remaining members of the SLC49 family, MFSD7 and DIRC2 (encoded by the SLC49A3 and SLC49A4 genes), are unknown, although the latter is implicated in hereditary renal carcinomas. SLC48A1 (heme responsive gene-1, HRG-1), the sole member of the SLC48 family, is associated with the endosome and appears to transport heme from the endosome into the cytosol.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}38{"query": "Miguel Angel Garcia Tebar (born 26 September 1979), known as Miguel Garcia, is a Spanish retired footballer who played as a defensive midfielder.", "pos": "Zhelyo Zhelev (born 24 February 1987 in Stara Zagora) is a Bulgarian footballer currently playing for Vereya Stara Zagora as a midfielder.", "neg": "Jefte Betancor Sanchez (born 6 July 1993) is a Spanish footballer who plays for UD Las Palmas Atletico as a forward.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}39{"query": "Coming off their Monday night road win over the Saints, the Vikings went home for a Week 6 NFC North duel with the Detroit Lions. In the first quarter, the Vikes got an early lead as Lions QB Dan Orlovsky unintentionally ran out of the back of his own end zone, giving Minnesota a safety which Orlovsky didn't know why the whistles were blown. In the second quarter, Detroit got the lead as kicker Jason Hanson got a 40-yard field goal. In the third quarter, the Lions increased their lead as Orlovsky completed a 12-yard TD pass to WR Calvin Johnson. The Vikings answered with QB Gus Frerotte completing an 86-yard TD pass to WR Bernard Berrian. In the end of the fourth quarter, the Vikes got in field goal range due to a controversial pass interference call on Leigh Bodden. The Vikes sealed the win with kicker Ryan Longwell nailing the game-winning 26-yard field goal.", "pos": "Hoping to rebound from their home loss to the Titans, the Bears flew to Lambeau Field for a Week 11 NFC North duel with their hated rival, the Green Bay Packers. In the first quarter, Chicago trailed early as Packers QB Aaron Rodgers completed a 3-yard TD pass to WR Greg Jennings. In the second quarter, the Bears got on the board with kicker Robbie Gould getting a 35-yard field goal. Green Bay would answer with RB Ryan Grant getting a 4-yard TD run, along with kicker Mason Crosby getting a 53-yard field goal. In the third quarter, Chicago continued to trail as Rodgers completed a 5-yard TD pass to TE Donald Lee. In the fourth quarter, the Packers pulled away as Crosby made a 33-yard field goal, DE Jason Hunter returned a fumble 54 yards for a touchdown, and Crosby nailing a 45-yard field goal.", "neg": "This game is well known for an infamous penalty that occurred during the overtime period. The Jets were lining up for a game winning 56-yard field goal in overtime to try and give them the win. Nick folk kicked the ball, but the kick went wide right and the Patriots appeared to be taking over with a chance to win. However, Chris Jones of New England was called for a controversial unsportsmanlike conduct penalty after pushing his teammate into the offensive line. This penalty would later be named \"leaping\". The penalty gave the Jets another chance and made the field goal attempt a 51-yard attempt. This time, Folk drilled the kick, and the Jets would go on to stun the Patriots. With the win, the Jets improved to 4-3.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}40{"query": "Australia has promised to introduce the most comprehensive carbon trading program outside Europe in 2010. The government in Canberra plans to cut greenhouse gas emissions by at least five percent by 2020, but it could make bigger reductions if other countries agree to tougher targets. The Australian government warns that without tough environmental measures the country could lose key industries and jobs. Climate Change Minister Penny Wong says the economy is under threat and decisive action is needed. Central to the government's climate change plan is a carbon emissions trading program that will be introduced within two years. It would involve one thousand of the nation's biggest companies and would cover about three-quarters of Australia's greenhouse gas emissions. Many scientists believe that greenhouse gases, such as carbon dioxide and methane, contribute to global warming. Many of them are released by burning fuels such as coal and oil. Companies will be required to buy permits for each ton of carbon they emit, although big polluting exporters will receive up to 90 percent of their carbon licenses free. Many business leaders want the government to delay the plan because of the current global financial crisis, which is slowing the Australian economy. Peter Anderson from the Australian Chamber of Commerce and Industry says it is irresponsible to bring in a carbon trading plan now. Environmentalists, on the other hand, say Prime Minister Kevin Rudd has not properly addressed the threat of climate change. Activists had sought a minimum emissions cut of 25 percent. Instead, the Rudd government aims to cuts carbon emissions by at least five percent of 2000 levels by 2020. That amount could rise to 15 percent, if future global agreements set such a target. Ray Nias of the environmental group WWF says Australia will pay the price for low targets. \"This is a deeply, deeply disappointing target,\" Nias said. \"It commits Australia to long-term climate change. It will make Australia's ability to negotiate global agreements very, very difficult. It is much lower than even we had imagined.\" Australia has one of the highest per-person greenhouse emissions rates in the world because of its reliance on coal for electricity. _", "pos": "Fossil fuels are made from plants and animals that lived hundreds of millions of years ago. The plants and animals died. Their remains settled onto the ground and at the bottom of the sea. Layer upon layer of organic material was laid down. Eventually, the layers were buried very deeply. They experienced intense heat and pressure. Over millions of years, the organic material turned into fossil fuels. Fossil fuels are compounds of carbon and hydrogen, called hydrocarbons. Hydrocarbons can be solid, liquid, or gas. The solid form is coal. The liquid form is petroleum, or crude oil. The gaseous form is natural gas. Coal is a solid hydrocarbon. Coal is useful as a fuel, especially for generating electricity. Coal forms from dead plants that settled at the bottom of swamps millions of years ago. Water and mud in the swamp kept oxygen away from the plant material. Sand and clay settled on top of the decaying plants. The weight of this material squeezed out the water and some other substances. Over time, the organic material became a carbon-rich rock. This rock is coal. Coal is a black or brownish-black rock that burns easily (Figure 5.3). Most coal is sedimentary rock. The hardest type of coal, anthracite, is a metamorphic rock. That is because it is exposed to higher temperature and pressure as it forms. Coal is mostly carbon, but some other elements can be found in coal, including sulfur. Around the world, coal is the largest source of energy for electricity. The United States is rich in coal. Pennsylvania and the region to the west of the Appalachian Mountains are some of the most coal-rich areas of the United States. Coal has to be mined to get it out of the ground. Coal mining affects the environment and human health. Coal mining can take place underground or at the surface. Each method has some advantages and disadvantages. Surface mining exposes minerals that were underground to air and water at the surface. These minerals contain the chemical element sulfur. Sulfur mixes with air and water to make sulfuric acid. This acid is a highly corrosive chemical. Sulfuric acid gets into nearby streams and can kill fish, plants, and animals. Surface mining is safer for the miners. Coal mining underground is dangerous for the coal miners. Miners are sometimes killed if there is an explosion or a mine collapse. Miners breathe in coal dust and can get terrible lung diseases after a number of years in the mines. To prepare coal for use, the coal is first crushed into powder and burned in a furnace. Like other fuels, coal releases most of its energy as heat when it burns. The heat from the burning coal is used to boil water. This makes steam. The steam spins turbines, which creates electricity. Oil is a thick, dark brown or black liquid. It is found in rock layers of the Earths crust. Oil is currently the most commonly used source of energy in the world. The way oil forms is similar in many ways to coal. Tiny organisms like plankton and algae die and settle to the bottom of the sea. Sediments settle over the organic material. Oxygen is kept away by the sediments. When the material is buried deep enough, it is exposed to high heat and pressure. Over millions of years, the organic material transforms into liquid oil. The United States produces only about one-quarter as much oil as it uses. The main oil producing regions in the U.S. are the Gulf of Mexico, Texas, Alaska, and California. Geologists look for oil in folded layers of rock called anticlines. Oil moves through permeable rock and is trapped by the impermeable cap rock. Oil comes out of the ground as crude oil. Crude oil is a mixture of many different hydrocarbons. Oil is separated into different compounds at an oil refinery (Figure 5.4). This is done by heating the oil. Each hydrocarbon compound in crude oil boils at a different temperature. We get gasoline, diesel, and heating oil, plus waxes, plastics, and fertilizers from crude oil. These fuels are", "neg": "Superfast doubledecker trains will be taking passengers from London to six big cities in the UK by 2033. The first phase linking London to the West Midlands with a connection to HS1 is expected to open in 2026, and the second phase to Manchester and Leeds in 2032. The government set out a plan for the highspeed rail network in 2012. When the project is finished, it will take less time to get to London from major cities like Birmingham, Manchester and Leeds. Traveling at a speed of up to 250 mph, passengers will be able to come and go from Birmingham to London in 49 minutes, reducing the journey time by almost half from one hour and 24 minutes. A journey from Birmingham to Leeds will be reduced from two hours to 57 minutes and a journey from Manchester to London will be reduced from two hours and 8 minutes to one hour and 8 minutes. \"HS2 is an important part of transport's lowcarbon future,\" Transport Secretary Justine Greening said. Some people aren't happy about the plan, though. HS2 will cost around PS33 billion. It will also be built near some towns and villages, disturbing the people that live there. But the Chancellor of the Exchequer George Osborne thinks it will help build the future for Britain. \"It's a longterm decision,\" he said. HS2 is designed for everything around the needs of the passengers. It will provide a new and exciting travel experience. There will be plenty of room, intelligent ticketing, a good service and high quality comfort and access to trains. This is a transport network for the new century and beyond.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}41{"query": "As of May, 2010, the California Secretary of State reports that San Benito County has 34,562 eligible voters. Of those 24,736 (71.57%) are registered voters. Of those, 11,959 (48.35%) are registered Democratic, 7,477 (30.23%) are registered Republican, 565 (2.28%)are registered American Independent, and 116 (0.47%) are Green Party. The two incorporated municipalities of Hollister and San Juan Bautista have Democratic majorities on their voter rolls, whereas the unincorporated areas of San Benito County have a small Republican plurality in voter registration.", "pos": "The 2010 United States Census reported that Marin County had a population of 252,409. The racial makeup of Marin County was 201,963 (80.0%) White (U.S. Census), 6,987 (2.8%) African American (U.S. Census), 1,523 (0.6%) Native American (U.S. Census), 13,761 (5.5%) Asian (U.S. Census), 509 (0.2%) Pacific Islander (U.S. Census), 16,973 (6.7%) from Race (United States Census), and 10,693 (4.2%) from two or more races. Hispanic (U.S. Census) or Latino (U.S. Census) of any race were 39,069 persons (15.5%).", "neg": "With transform plate boundaries, the two slabs of lithosphere are sliding past each other in opposite directions. The boundary between the two plates is a transform fault. Transform faults on continents separate two massive plates of lithosphere. As they slide past each other, they may have massive earthquakes. The San Andreas Fault in California is perhaps the worlds most famous transform fault. Land on the west side is moving northward relative to land on the east side. This means that Los Angeles is moving northward relative to Palm Springs. The San Andreas Fault is famous because it is the site of many earthquakes, large and small. (Figure At the San Andreas Fault in California, the Pacific Plate is sliding northeast relative to the North American plate, which is moving southwest. At the northern end of the picture, the transform boundary turns into a subduction zone. Transform plate boundaries are also found in the oceans. They divide mid-ocean ridges into segments. In the diagram of western North America, the mid-ocean ridge up at the top, labeled the Juan de Fuca Ridge, is broken apart by a transform fault in the oceans. A careful look will show that different plates are found on each side of the ridge: the Juan de Fuca plate on the east side and the Pacific Plate on the west side.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}42{"query": "A cell is the smallest structural and functional unit of an organism. Some organisms, like bacteria, consist of only one cell. Big organisms, like humans, consist of trillions of cells. Compare a human to a banana. On the outside, they look very different, but if you look close enough youll see that their cells are actually very similar. Most cells are so small that you cannot see them without the help of a microscope. It was not until 1665 that English scientist Robert Hooke invented a basic light microscope and observed cells for the first time, by looking at a piece of cork. You may use light microscopes in the classroom. You can use a light microscope to see cells ( Figure 1.1). But many structures in the cell are too small to see with a light microscope. So, what do you do if you want to see the tiny structures inside of cells? In the 1950s, scientists developed more powerful microscopes. A light microscope sends a beam of light through a specimen, or the object you are studying. A more powerful microscope, called an electron microscope, passes a beam of electrons through the specimen. Sending electrons through a cell allows us to see its smallest parts, even the parts inside the cell ( Figure 1.2). Without electron microscopes, we would not know what the inside of a cell looked like. The outline of onion cells are visible under a light microscope. In 1858, after using microscopes much better than Hookes first microscope, Rudolf Virchow developed the hypoth- esis that cells only come from other cells. For example, bacteria, which are single-celled organisms, divide in half (after they grow some) to make new bacteria. In the same way, your body makes new cells by dividing the cells you already have. In all cases, cells only come from cells that have existed before. This idea led to the development of one of the most important theories in biology, the cell theory. Cell theory states that: 1. All organisms are composed of cells. 2. Cells are alive and the basic living units of organization in all organisms. 3. All cells come from other cells. As with other scientific theories, many hundreds, if not thousands, of experiments support the cell theory. Since Virchow created the theory, no evidence has ever been identified to contradict it. Although cells share many of the same features and structures, they also can be very different ( Figure 1.3). Each cell in your body is designed for a specific task. In other words, the cells function is partly based on the cells structure. For example: Red blood cells are shaped with a pocket that traps oxygen and brings it to other body cells. Nerve cells are long and stringy in order to form a line of communication with other nerve cells, like a wire. Because of this shape, they can quickly send signals, such as the feeling of touching a hot stove, to your brain. Skin cells are flat and fit tightly together to protect your body. As you can see, cells are shaped in ways that help them do their jobs. Multicellular (many-celled) organisms have many types of specialized cells in their bodies. Red blood cells (left) are specialized to carry oxygen in the blood. Neurons (cen- ter ) are shaped to conduct electrical im- pulses to many other nerve cells. These epidermal cells (right) make up the skin of plants. Note how the cells fit tightly together. While cells are the basic units of an organism, groups of cells can perform a job together. These cells are called specialized because they have a special job. Specialized cells can be organized into tissues. For example, your liver cells are organized into liver tissue. Your liver tissue is further organized into an organ, your liver. Organs are formed from two or more specialized tissues working together to perform a job. All organs, from your heart to your liver, are made up of an organized group of tissues. These organs are part of a larger system, the organ systems. For example, your brain works", "pos": "Microscopes, tools that you may get to use in your class, are some of the most important tools in biology ( Figure Microscopy is the study of small objects using microscopes. Look at your fingertips. Before microscopes were invented in 1595, the smallest things you could see on yourself were the tiny lines in your skin. But what else is hidden in your skin? Over four hundred years ago, two Dutch spectacle makers, Zaccharias Janssen and his son Hans, were experimenting with several lenses in a tube. They discovered that nearby objects appeared greatly enlarged, or magnified. This was the forerunner of the compound microscope and of the telescope. In 1665, Robert Hooke, an English natural scientist, used a microscope to zoom in on a piece of cork - the stuff that makes up the stoppers in wine bottles, which is made from tree bark. Inside of cork, he discovered tiny structures, which he called cells. It turns out that cells are the smallest structural unit of living organisms. This finding eventually led to the development of the theory that all living things are made of cells. Without microscopes, this discovery would not have been possible, and the cell theory would not have been developed. Hookes discovery of the cell set the stage for other scientists to discover other types of organisms. After Hooke, the \"father of microscopy,\" Dutch scientist Antoine van Leeuwenhoek ( Figure 1.2) taught himself to make one of the first microscopes. In one of his early experiments, van Leeuwenhoek took a sample of scum from his own teeth and used his microscope to discover bacteria, the smallest living organism on the planet. Using microscopes, van Leeuwenhoek also discovered one-celled protists and sperm cells. Today, microscopes are used by all types of scientists, including cell biologists, microbiologists, virologists, forensic scientists, entomologists, taxonomists, and many other types. Antoine van Leeuwenhoek, a Dutch cloth merchant with a passion for microscopy. Some modern microscopes use light, as Hookes and van Leeuwenhoeks did. Others may use electron beams or sound waves. Researchers now use these four types of microscopes: 1. Light microscopes allow biologists to see small details of a specimen. Most of the microscopes used in schools and laboratories are light microscopes. Light microscopes use lenses, typically made of glass or plastic, to focus light either into the eye, a camera, or some other light detector. The most powerful light microscopes can make images up to 2,000 times larger. 2. Transmission electron microscopes (TEM) focus a beam of electrons through an object and can make an image up to two million times bigger, with a very clear image. 3. Scanning electron microscopes (SEM) allow scientists to find the shape and surface texture of extremely small objects, including a paperclip, a bedbug, or even an atom. These microscopes slide a beam of electrons across the surface of a specimen, producing detailed maps of the surface of objects. Magnification in a SEM can be controlled over a range from about 10 to 500,000 times. 4. Scanning acoustic microscopes use sound waves to scan a specimen. These microscopes are useful in biology and medical research. Scanning Electron Microscope at (5:04) Click image to the left or use the URL below. URL: 1. How is the electron beam focused? 2. What part of a specimen does a scanning electron microscope look at? 3. Why is it important that a specimen for an electron microscope be placed in a vacuum? Why is this step unnecessary for a light microscope?", "neg": "Many life science discoveries would not have been possible without the microscope. For example: Cells are the tiny building blocks of living things. They couldnt be discovered until the microscope was invented. The discovery of cells led to the cell theory. This is one of the most important theories in life science. Bacteria are among the most numerous living things on the planet. They also cause many diseases. However, no one knew bacteria even existed until they could be seen with a microscope. The invention of the microscope allowed scientists to see cells, bacteria, and many other structures that are too small to be seen with the unaided eye. It gave them a direct view into the unseen world of the extremely tiny. You can get a glimpse of that world in Figure 1.10. The microscope was invented more than four centuries ago. In the late 1500s, two Dutch eyeglass makers, Zacharias Jansen and his father Hans, built the first microscope. They put several magnifying lenses in a tube. They discovered that using more than one lens magnified objects more than a single lens. Their simple microscope could make small objects appear nine times bigger than they really were. In the mid-1600s, the English scientist Robert Hooke was one of the first scientists to observe living things with a microscope. He published the first book of microscopic studies, called Micrographia. It includes wonderful drawings of microscopic organisms and other objects. One of Hookes most important discoveries came when he viewed thin slices of cork under a microscope. Cork is made from the bark of a tree. When Hooke viewed it under a microscope, he saw many tiny compartments that he called cells. He made the drawing in Figure 1.11 to show what he observed. Hooke was the first person to observe the cells from a once-living organism. In the late 1600s, Anton van Leeuwenhoek, a Dutch lens maker and scientist, started making much stronger microscopes. His microscopes could magnify objects as much as 270 times their actual size. Van Leeuwenhoek made many scientific discoveries using his microscopes. He was the first to see and describe bacteria. He observed them in a sample of plaque that he had scraped off his own teeth. He also saw yeast cells, human sperm cells, and the microscopic life teeming in a drop of pond water. He even saw blood cells circulating in tiny blood vessels called capillaries. The drawings in Figure 1.12 show some of tiny organisms and living cells that van Leeuwenhoek viewed with his microscopes. He called them animalcules. These early microscopes used lenses to refract light and create magnified images. This type of microscope is called a light microscope. Light microscopes continued to improve and are still used today. The microscope you might use in science class is a light microscope. The most powerful light microscopes now available can make objects look up to 2000 times their actual size. You can learn how to use a light microscope by watching this short video: http MEDIA Click image to the left or use the URL below. URL: To see what you might observe with a light microscope, watch the following video. It shows some amazing creatures in a drop of stagnant water from an old boat. What do you think the creatures might be? Do they look like any of van Leeuwenhoeks animalcules in Figure 1.12? MEDIA Click image to the left or use the URL below. URL: For an object to be visible with a light microscope, it cant be smaller than the wavelength of visible light (about 550 nanometers). To view smaller objects, a different type of microscope, such as an electron microscope, must be used. Electron microscopes pass beams of electrons through or across an object. They can make a very clear image that is up to 2 million times bigger than the actual object. An electron microscope was used to make the image of the ant head in Figure 1.10.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}43{"query": "The Thredbo River, a perennial river of the Snowy River catchment, is located in the Snowy Mountains region of New South Wales, Australia.", "pos": "Bimberamala River, a perennial river of the Clyde River catchment, is located in the Southern Tablelands and the upper ranges of the South Coast regions of New South Wales, Australia.", "neg": "The Paraul Malurilor is a tributary of the Dragan River in Romania.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}44{"query": "Billie Jenkins is a fictional character on The WB television series Charmed.", "pos": "Helen Cunningham (previously Richardson) is a fictional character from the long-running Channel 4 soap opera, Hollyoaks, played by Kathryn George.", "neg": "The figure of a limp woman with long curly hair is seen drifting underwater, and a voiceover questions the end of a life that never truly existed. This life ended in murder, the victim herself unsure of who her killer was and why she was killed. Her death was only metaphorical, for in her place a new life begins.The story starts with Patience Phillips (Halle Berry), a timid woman who can't stand up for herself. She lets people walk all over her, and has wasted her artistic talent working for a cosmetic company as a graphic designer. George Hedare (Lambert Wilson) runs the company with his supermodel wife, Laurel (Sharon Stone). Laurel knows that Patience is capable, but seems mostly indifferent, only using her in own power struggles with her husband. George, an abusive boss in general, finds plenty of opportunity to mock Laurel.The company is about to launch BeauLine, a new anti-aging product that Laurel had secretly been using for years. The advertisement is designed by Patience but George, unsatisfied, demands that she redesigns it. Upset and frustrated, Patience returns home and sees a cat looking up at her. Shaking her head, she goes to sleep, but her loud neighbours keeps her up and she is unable to rest. Next morning, the cat is on her window ledge. When she approaches, she realizes the cat has climbed up to a higher ledge and was potentially stuck. To try and reach the cat, Patience climbs out her window ledge, and a passing detective mistakens her intentions as suicidal. He ends up rushing into her apartment and pulling her back in. Patience would have thanked him but realizes she is late for work, in her hurry to leave she drops her wallet. The detective, Tom Lone (Benjamin Bratt), tracks her down to her workplace and returns it to her, and both agree to a coffee date.Later that night, Patience goes to the production factory to deliver her artwork, and she accidentally hears that the BeauLine has unsafe health problems. Stunned, she backs into several tools, revealling her presence. Two men chase her into a large waste water pipe, where she is trapped, and they flush her into the river, where she drowns. The cat that has been appearing in front of Patience appears by her body and gathers several other cats around her.Patience eventually drags herself unsteadily up and returns home. Her movements are off and uncontrollable, and she ends up breaking the glass through her own window. When her neighbours start their usual loud party again, she yells at them to quiet but they again ignore her. The old Patience would have backed down, but now she strodes down, knocks on their door, and promptly beats up the host and destroys the music equipment in front of many shocked guests. When she wakes up the next morning, she almost dismisses everything as a dream until she sees the broken glass. Unfortunately, her memories of what happened before that are blank, and so she cluelessly returns back to work.At work, George loudly yells at Patience in front of all her coworkers for not handling in her project. She tunes him out, which angers him further, and when she apologizes he only continues. Patience than apologizes for wasting her time in the company, and is fired, but as soon as George leaves her colleagues swarm around her in congratulations. Patience packs up her things and while she and her friends are walking home, two dogs instantly begin barking at her and she instinctively hisses at them. When questioned, she explains her behaviour as allergies. When they pass by a jewelry store, Patience's attention is caught by a beautiful collar-like necklace, but is reminded of her new unemployed status and leaves longingly. Once home, she sees the same cat again, and finally close enough she was able to find the address on the cat's owner.The cat belonged to an older woman named Ophelia, a former professor who lived alone in a house full of cats. She explains that the cat constantly appearing in front of Patience is named Midnight, a rare Egyptian", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}45{"query": "Redfield Proctor (June 1, 1831 -- March 4, 1908) was a U.S. politician of the Republican Party.", "pos": "Jim Honeyford (born January 24, 1939) is an American politician of the Republican Party.", "neg": "Elie Lacoste (18 September 1745, Montignac - 26 November 1806, Montignac) was a French politician during the French Revolution.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}46{"query": "As of the census of 2000, there were 325,957 people, 149,937 households, and 94,460 families residing in the county. The population density was 570 people per square mile (220/km2). There were 182,467 housing units at an average density of 319 per square mile (123/km2). The racial makeup of the county was 92.65% Race (United States Census), 4.18% Race (United States Census) or Race (United States Census), 0.22% Race (United States Census), 0.77% Race (United States Census), 0.03% Race (United States Census), 1.14% from Race (United States Census), and 1.02% from two or more races. 4.34% of the population were Race (United States Census) or Race (United States Census) of any race. 89.7% spoke only English language at home; 4.4% spoke Spanish language, 1.3% German language, and 1.0% French language at home.", "pos": "As of the census of 2000, there were 445,342 people, 169,162 households, and 114,015 families residing in the county. The population density was 615 people per square mile (238/km). There were 178,913 housing units at an average density of 247 per square mile (95/km). The racial makeup of the county was 82.19% Race (United States Census), 1.15% Race (United States Census) or Race (United States Census), 0.65% Race (United States Census), 6.68% Race (United States Census), 0.30% Race (United States Census), 5.86% from Race (United States Census), and 3.17% from two or more races. 11.17% of the population were Race (United States Census) or Race (United States Census) of any race. 17.2% were of German American, 9.9% English American, 8.2% Irish American, and 6.7% Americans ancestry. 81.7% spoke only English at home, while 9.6% spoke Spanish and 1.2% Vietnamese.", "neg": "As of the census of 2000, there were 35,100 people, 12,759 households, and 9,071 families residing in the county. The population density was 59 people per square mile (23/km). There were 15,035 housing units at an average density of 25 per square mile (10/km). The racial makeup of the county was 85.8% Race (United States Census), 3.9% Race (United States Census) or Race (United States Census), 1.8% Race (United States Census), 1.0% Race (United States Census), 0.1% Race (United States Census), 5.0% from Race (United States Census), and 2.4% from two or more races. 8.9% of the population were Race (United States Census) or Race (United States Census) of any race. 14.9% were of German people, 12.6% English people, 11.7% Irish people, 8.8% Italian people and 7.3% United States ancestry according to Census 2000. 93.1% spoke English language and 5.1% Spanish language as their first language.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}47{"query": "Sheikha Al-Mayassa bint Hamad bin Khalifa Al-Thani (born 1983) is the sister of Qatar's ruling Emir Tamim bin Hamad Al Thani, and daughter of the country's Father Emir Hamad bin Khalifa Al Thani and former First Lady Moza bint Nasser.", "pos": "Isias was the daughter of King Ariobarzanes I of Cappadocia and his wife Queen Athenais Philostorgos I, while her brother was King Ariobarzanes II of Cappadocia.", "neg": "Toni Young (born January 11, 1991) is an American professional basketball player who last played for the New York Liberty of the WNBA.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}48{"query": "An earthquake is sudden ground movement caused by the sudden release of energy stored in rocks. Earthquakes happen when so much stress builds up in the rocks that the rocks rupture. The energy is transmitted by seismic waves. Earthquakes can be so small they go completely unnoticed, or so large that it can take years for a region to recover. The description of how earthquakes occur is called elastic rebound theory (Figure 1.1). Elastic rebound theory. Stresses build on both sides of a fault, causing the rocks to deform plastically (Time 2). When the stresses become too great, the rocks break and end up in a different location (Time 3). This releases the built up energy and creates an earthquake. Click image to the left or use the URL below. URL: In an earthquake, the initial point where the rocks rupture in the crust is called the focus. The epicenter is the point on the land surface that is directly above the focus (Figure 1.2). In the vertical cross section of crust, there are two features labeled - the focus and the epicenter, which is directly above the focus. Click image to the left or use the URL below. URL:", "pos": "Almost all earthquakes occur at plate boundaries. All types of plate boundaries have earthquakes. Convection within the Earth causes the plates to move. As the plates move, stresses build. When the stresses build too much, the rocks break. The break releases the energy that was stored in the rocks. The sudden release of energy creates an earthquake. During an earthquake the rocks usually move several centimeters or rarely as much as a few meters. Elastic rebound theory describes how earthquakes occur (Figure 7.21). Where an earthquake takes place is described by its focus and epicenter. The point where the rock ruptures is the earthquakes focus. The focus is below the Earths surface. A shallow earthquake has a focus less than 70 kilometers (45 miles). An intermediate-focus earthquake has a focus between 70 and 300 kilometers (45 to 200 miles). A deep-focus earthquake is greater than 300 kilometers (200 miles). About 75% of earthquakes have a focus in the top 10 to 15 kilometers (6 to 9 miles) of the crust. Shallow earthquakes cause the most damage. This is because the focus is near the Earths surface, where people live. The area just above the focus, on the land surface, is the earthquakes epicenter (Figure 7.22). The towns or cities near the epicenter will be strongly affected by the earthquake. Nearly 95% of all earthquakes take place along one of the three types of plate boundaries. As you learned in the Plate Tectonics chapter, scientists use the location of earthquakes to draw plate boundaries. The region around the Pacific Ocean is called the Pacific Ring of Fire. This is due to the volcanoes that line the region. The area also has the most earthquakes. About 80% of all earthquakes strike this area. The Pacific Ring of Fire is caused by the convergent and transform plate boundaries that line the Pacific Ocean basin. About 15% of all earthquakes take place in the Mediterranean-Asiatic belt. The convergent plate boundaries in the region are shrinking the Mediterranean Sea. The convergence is also causing the Himalayas to grow. The remaining 5% of earthquakes are scattered around the other plate boundaries. A few earthquakes take place in the middle of a plate, away from plate boundaries. Transform plate boundaries produce enormous and deadly earthquakes. These quakes at transform faults have shallow focus. This is because the plates slide past each other without moving up or down. The largest earthquake on the San Andreas Fault occurred in 1906 in San Francisco. Other significant earthquakes in California include the 1989 Loma Prieta earthquake near Santa Cruz (Figure 7.23) and the 1994 Northridge earthquake near Los Angeles. There are many other faults spreading off the San Andreas, which produce around 10,000 earthquakes a year (Figure Convergent plate boundaries also produce strong, deadly earthquakes. Earthquakes mark the motions of colliding plates and the locations where plates plunge into the mantle. These earthquakes can be shallow, intermediate or deep focus. The Philippine plate and the Pacific plate subduct beneath Japan, creating as many as 1,500 earthquakes every year. In March 2011, the 9.0 magnitude Tohoku earthquake struck off of northeastern Japan. Damage from the quake was severe. More severe was the damage from the tsunami generated by the quake (Figure 7.25). In all, 25,000 people were known dead or missing. The Cascades Volcanoes line the Pacific Northwest of the United States. Here, the Juan de Fuca plate subducts beneath the North American plate. The Cascades volcanoes are active and include Mount Saint Helens. Major earthquakes occur here approximately every 300 to 600 years. The last was in 1700. Its magnitude was between 8.7 and 9.2. It has now been more than 300 years since that earthquake. The next massive earthquake could strike the Pacific Northwest at any time. The collision of two continents also creates massive earthquakes. Many earthquakes happen in the region in and around the Himalayan Mountains. The 2001 Gujarat, India earthquake is responsible for about 20,000 deaths, with many more people injured or made homeless. Earthquakes also occur at divergent plate boundaries. At mid-ocean ridges, these earthquakes tend to be small and shallow focus because the", "neg": "The lithosphere is composed of both the crust and the portion of the upper mantle that behaves as a brittle, rigid solid. The lithosphere is the outermost mechanical layer, which behaves as a brittle, rigid solid. The lithosphere is about 100 kilometers thick. How are crust and lithosphere different from each other? The definition of the lithosphere is based on how Earth materials behave, so it includes the crust and the uppermost mantle, which are both brittle. Since it is rigid and brittle, when stresses act on the lithosphere, it breaks. This is what we experience as an earthquake. Although we sometimes refer to Earths plates as being plates of crust, the plates are actually made of lithosphere. Much more about Earths plates follows in the chapter \"Plate Tectonics.\" The asthenosphere is solid upper mantle material that is so hot that it behaves plastically and can flow. The lithosphere rides on the asthenosphere.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}49{"query": "Its been over a year since the Alaskan town of Barrow's population was decimated by a gang of vampires during its annual month long sunset. Riddled with grief over the death of her husband, bound by nightmares and void of all emotions beyond hate and sorrow, Stella (Kiele Sanchez) has spent the past months traveling the world, trying to convince others that vampires exist in this world.Constantly feeling as though she is being hunted, Stella is well aware the impending threat on her life, the death of her husband Eben having taken from her her ability to feel emotions, leaving her feeling cold and empty inside. Following instructions from a mysterious man named Dane, she eventually ends up in Los Angeles.One night, while giving a lecture to an audience of people with whom she hopes to convince that vampires exist and aware that they attend when she speaks, she activates overhead ultraviolet lamps that incinerate several of the vampires in the audience before the humans. She is quickly arrested and harassed by a man named FBI Agent Norris whom she quickly learns that he is a 'familiar' (bug-eater) one of the many thousands of human followers of the vampires all over the world, placed to keep their activities covered up. After they release her from custody with a warning to keep quiet about the existence of vampires, she returns to her hotel room to find three people waiting for her; Paul (Rhys Coiro), Amber (Diora Baird) and Todd (Harold Perrineau) who had been sent by Dane to collect her in order to hunt down the vampire queen Lilith, whom they are convinced once out of the way, the vampires will fall into more-or-less form of dormancy as she is responsible for their every move and for keeping them hidden, when Stella asks if she is responsible for the incident at Barrow and is notified that she was. She is taken to meet Dane (Ben Cotton) and is shocked to discover that he too is a vampire, though due to a superficially inflicted wound he has maintained a grasp of humanity, only drinking blood from packaged hospital stocks he keeps.At first hesitant to join in on a plan to attack a vampire nest, Paul eventually convinces Stella to join them, telling her of his daughter being killed by one and his accusations of a vampire killing her resulting in a divorce with his wife.The following day, the four of them find their way to a vampire's nest and they are ambushed by a group of them. In the attempt to flee, Todd is bitten and turns after they lock themselves in a cellar room. When Paul hesitates, Stella manages to kill him by smashing in his head with a cinder block. They decide to wait for night when the vampires go out to feed in order to make their escape.After night falls, Dane comes and frees them, on their way out they capture a vampire. Taking him back to their base of operations, Dane interrogates the non-English speaking animalistic vamp with ultraviolet lamps, eventually following him back to another nest. They invade the nest and rescue a human they were using as a feeding station and with her memories of Lilith's lair aboard one of the ships on the bay they are able to plan an attack on her directly.At Dane's place, Stella and Paul get intimate and have sex. Meanwhile, Lilith (Mia Kirshner) decides that Agent Norris should prove his worth to become a vampire (in order to cure throat or lung cancer he has been suffering from) and he bites the neck of a captive girl, named Stacey (Katharine Isabelle), drinking her blood until dead. Afterward she turns him to hunt Stella and the others.Dane is killed when Norris arrives, and the others flee with the survivor from the nest, they travel to a boat yard and Jennifer points out the boat that they are set to sail to Alaska in for another 30 day feeding period. They tell Jennifer to leave and the three of them stowaway on the ship and discover that vampires can be resurrected after death if their corpses are fed human blood. They eventually confront the human captain who says", "pos": "Linda Westinghouse [Ewa Stromberg], a lawyer with the Istanbul firm of Simpson & Sons, is sent to Anatolia to handle the inheritance of Countess Nadine Carody, recipient of the entire estate of Count Dracula of Hungary. To Linda's surprise, Nadine [Soledad Miranda] is the strange woman who has been haunting her dreams for the past several weeks. Nadine is also a vampire and, after sharing a swim, a glass of wine, and some kisses, Nadine bites Linda's neck and drinks some of her blood. When Linda comes to and goes in search of Nadine, she finds her floating in the swimming pool, apparently dead. The next thing Linda knows, she is being treated at Dr Aldon Seward's clinic, bewildered as to how she got there and amnesic as to her name and address. Dr Seward [Dennis Price] puts a notice in the newspaper, which brings Linda's boyfriend Omar [Andres Monales] looking for her. Linda remembers Omar but still remembers nothing that went on at Countess Carody's beachhouse. Her only memory is of the Countess lying dead in the swimming pool and then being alone at sea. She wonders if it was all a dream.However, Nadine is not dead. She is languishing on a couch, telling her renfield Morpho [Jose Martinez Blanco] how she became a vampire (Dracula saved her from being raped and initiated her into the secret of the vampires) and how she now hates men and is so infatuated with Linda that she must make Linda into a vampire, too. Hearing Nadine calling to her, Linda goes. Nadine drinks a bit more of Linda's blood. Later, Linda consults with Dr Seward who tells her that, if she wishes to extract herself from the spell of the vampire, she must either split the vampire's head with an axe or pierce it with a pole.Meanwhile, one of Dr Seward's patients, Agra [Heidrun Kussin], who has been alternately babbling about the Queen of the Night (Nadine) coming to see her and then abandoning her, now suddenly announces that the Queen is going to come to the sanitarium to meet Seward. Nadine shows up at the sanitarium, angry with Seward for trying to take Linda away from her. Seward admits that he only did it to get Nadine to come to him. He wants to become initiated into the world of the vampires. When Nadine refuses and Seward starts shouting Latin at her, Nadine gets Morpho to kill Seward while she pays a visit with Agra in order to tell her that she's going to leave her again.Meanwhile, Linda goes missing. Omar enlists the help of Linda's shrink, Dr Steiner [Paul Muller], in tracking down Nadine in hopes of finding Linda. Actually, Linda is being held by Memmet [Jesus Franco], the bellboy at her hotel. Turns out Memmet was Agra's husband before she became bewitched by Nadine. Memmet has fallen for Linda and wants to kill her, but Linda kills him first and then escapes. Steiner and Omar go to Nadine's house in Istanbul, but she and Morpho have returned to their beachhouse in Anatolia. Linda goes there, too. She finds Nadine lying in bed, dying. Nadine begs Linda for some blood, but Linda doesn't want to be under Nadine's power and stabs her through the eye. Nadine's body disappears. Morpho kills himself. Omar and Steiner arrive on a boat. Omar tries to convince Linda that it was all a dream, but Linda knows better. [Original Synopsis by bj_kuehl.]", "neg": "The movie begins in the year 1967 with a pregnant woman being admitted to a hospital, bleeding from the neck. Paramedics think she was attacked by some type of animal. Doctors perform an emergency C-Section, and her baby (a boy) is born alive just as she dies.Thirty years later a young man named Dennis (Kenny Johnson) is riding in a car with an attractive redhead named Racquel (Traci Lords) heading to an underground nightclub (located, oddly, in a slaughterhouse) somewhere in Los Angeles. After addressing the doorman in Russian, Racquel brings the young man into the club. The man is confused and trying to understand the rules of the club. Some of the regulars indifferently push him aside. Saying he needs a drink, the sprinkler suddenly system activates, raining blood down on everyone inside. It is then that he (and the audience) realizes that everyone in the club is a vampire.Dennis desperately tries to get away and winds up at the feet of a menacing figure in a black-leather trenchcoat. The vampires look on this figure with awe, mumbling the words: \"it's the Daywalker!\" This is our first look at Blade (Wesley Snipes), the vampire killer.Blade pulls out a shotgun and opens fire on the vampires, who instantly burn to ashes when killed. When the gun is knocked out of his hands by Racquel, Blade uses a set of silver stakes to kill Racquel and more vampires, including the disk jockey. Soon all the vamps are either dead or have fled except for one; a heavyset vamp named Quinn (Donal Logue), whom Blade has apparently run into before. Blade pins Quinn to the wall, and then sets him on fire before confronting the last member in the club (the human man from the beginning). Finding no vampire bite marks on Dennis, Blade lets him live and makes his escape as the police arrive.Quinn is extinguished and taken to the local hospital. A morgue technician examines his blood and shows the results to Dr. Karen Jenson (N'Bushe Wright), who finds a number of irregularities, including abnormally developed jaw muscles. As they are discussing the test results, Quinn springs back to life and bites both doctors. Before he can finish Dr. Jenson, Blade shows up and saves her, cutting off one of Quinn's arms.Blade brings Karen to his hideout and asks for help from his mentor, an elderly man named named Whistler (Kris Kristofferson). Whistler injects Dr. Jenson with a solution of garlic essence and silver nitrate and remarks that she has a 50/50 chance of recovering.Meanwhile, a group of vampires are discussing Blade's latest attack on their members. Apparently this club (and to an extent, Quinn) is the property of a vampire named Deacon Frost (Stephen Dorff). Frost wants the vampires to outright rule the humans and use them as a food source while the others (particularly an older vampire named Dragonetti) prefer to maintain a peaceful co-existance. Dragonetti (Udo Kier) in particular does not like Frost because Frost is not a \"pure-blood\" (ie: was not born a vampire, merely became one through the bite of another). Frost is also arrogant and his & the actions of his followers draw unnecessary attention to the vampire underworld.The next morning, Jenson awakens and sees Whistler injecting Blade with some type of serum. She tries to run away but Whistler confronts her and tells her that he and Blade are hunting vampires. Karen of course is skeptical, but Whistler goes on to talk about what they use to hunt- explaining that vampires are severely allergic to silver & garlic while also being vulnerable to sunlight (ultraviolet rays in particular). Whistler fuels up Blade's car and gives him a new UV flashlight to use when hunting that night. Whistler also gives Karen a type of \"vampire mace\" (garlic & silver nitrate in a liquid form).Blade drops Karen off at her apartment and she tries to pack up and get out of town. A police officer, identifying himself as Officer Krieger (Kevin Patrick Walls), arrives and questions her about the events", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}50{"query": "Asexual reproduction is simpler than sexual reproduction. It involves just one parent. The offspring are genetically identical to each other and to the parent. All prokaryotes and some eukaryotes reproduce this way. There are several different methods of asexual reproduction. They include binary fission, fragmentation, and budding. Binary fission occurs when a parent cell simply splits into two daughter cells. This method is described in detail in the lesson \"Cell Division.\" Bacteria reproduce this way. You can see a bacterial cell reproducing by binary fission in Figure 5.9. Fragmentation occurs when a piece breaks off from a parent organism. Then the piece develops into a new organism. Sea stars, like the one in Figure 5.10, can reproduce this way. In fact, a new sea star can form from a single arm. Budding occurs when a parent cell forms a bubble-like bud. The bud stays attached to the parent while it grows and develops. It breaks away from the parent only after it is fully formed. Yeasts can reproduce this way. You can see two yeast cells budding in Figure 5.11. Sexual reproduction is more complicated. It involves two parents. Special cells called gametes are produced by the parents. A gamete produced by a female parent is generally called an egg. A gamete produced by a male parent is usually called a sperm. An offspring forms when two gametes unite. The union of the two gametes is called fertilization. You can see a human sperm and egg uniting in Figure 5.12. The initial cell that forms when two gametes unite is called a zygote. In species with sexual reproduction, each cell of the body has two copies of each chromosome. For example, human beings have 23 different chromosomes. Each body cell contains two of each chromosome, for a total of 46 chromosomes. You can see the 23 pairs of human chromosomes in Figure 5.13. The number of different types of chromosomes is called the haploid number. In humans, the haploid number is 23. The number of chromosomes in normal body cells is called the diploid number. The diploid number is twice the haploid number. In humans, the diploid number is two times 23, or 46. The two members of a given pair of chromosomes are called homologous chromosomes. We get one of each homologous pair, or 23 chromosomes, from our father. We get the other one of each pair, or 23 chromosomes, from our mother. A gamete must have the haploid number of chromosomes. That way, when two gametes unite, the zygote will have the diploid number. How are haploid cells produced? The answer is meiosis. Meiosis is a special type of cell division. It produces haploid daughter cells. It occurs when an organism makes gametes. Meiosis is basically mitosis times two. The original diploid cell divides twice. The first time is called meiosis I. The second time is called meiosis II. However, the DNA replicates only once. It replicates before meiosis I but not before meiosis II. This results in four haploid daughter cells. Meiosis I and meiosis II occurs in the same four phases as mitosis. The phases are prophase, metaphase, anaphase, and telophase. However, meiosis I has an important difference. In meiosis I, homologous chromosomes pair up and then separate. As a result, each daughter cell has only one chromosome from each homologous pair. Figure 5.14 is a simple model of meiosis. It shows both meiosis I and II. You can read more about the stages below. You can also learn more about them by watching this video: . MEDIA Click image to the left or use the URL below. URL: After DNA replicates during interphase, the nucleus of the cell undergoes the four phases of meiosis I: 1. Prophase I: Chromosomes form, and the nuclear membrane breaks down. Centrioles move to opposite poles of the cell. Spindle fibers form between the centrioles. Heres whats special about meiosis: Homologous chromosomes pair up! You can see this in Figure below. 2. Metaphase I: Spindle fibers attach to the centromeres of the paired homologous chromosomes. The paired chromosomes line up at the center of", "pos": "The genetic information of the cell, or DNA, is stored in the nucleus. During mitosis, two nuclei (plural for nucleus) must form, so that one nucleus can be in each of the new cells after the cell divides. In order to create two genetically identical nuclei, DNA inside of the nucleus must be copied or replicated. This occurs during the S phase of the cell cycle. During mitosis, the copied DNA is divided into two complete sets, so that after cytokinesis, each cell has a complete set of genetic instructions. To begin mitosis, the DNA in the nucleus wraps around proteins to form chromosomes. Each organism has a unique number of chromosomes. In human cells, our DNA is divided up into 23 pairs of chromosomes. Replicated DNA forms a chromosome made from two identical sister chromatids, forming an \"X\" shaped molecule ( Figure 1.1). The two chromatids are held together on the chromosome by the centromere. The centromere is also where spindle fiber microtubules attach during mitosis. The spindles separate sister chromatids from each other. During mitosis, the two sister chromatids must be divided. This is a precise process that has four individual phases to it. After the sister chromatids separate, each separate chromatid is now known as a chromosome. Each resulting chromosome is made of DNA from just one chromatid. So, each chromosome after this separation is made of \"1/2 of the X.\" Through this process, each daughter cell receives one copy of each chromosome. The four phases of mitosis are prophase, metaphase, anaphase and telophase ( Figure 1.2). 1. Prophase: The chromatin, which is unwound DNA, condenses forming chromosomes. The DNA becomes so tightly wound that you can see them under a microscope. The membrane around the nucleus, called the nuclear envelope, disappears. Spindles also form and attach to chromosomes to help them move. 2. Metaphase: The chromosomes line up in the center, or the equator, of the cell. The chromosomes line up in a row, one on top of the next. 3. Anaphase: The two sister chromatids of each chromosome separate as the spindles pull the chromatids apart, resulting in two sets of identical chromosomes. 4. Telophase: The spindle dissolves and nuclear envelopes form around the chromosomes in both cells. An overview of the cell cycle and mito- sis: during prophase the chromosomes condense, during metaphase the chromo- somes line up, during anaphase the sister chromatids are pulled to opposite sides of the cell, and during telophase the nuclear envelope forms. This is a representation of dividing plant cells. Cell division in plant cells differs slightly from animal cells as a cell wall must form. Note that most of the cells are in interphase. Can you find examples of the different stages of mitosis?", "neg": "Fungi (fungus, singular) are relatively simple eukaryotic organisms. They are placed in their own kingdom, the Fungus Kingdom. Most fungi are multicellular organisms. These fungi are called molds. However, some fungi exist as single cells. These fungi are called yeasts. You can see examples of different types of fungi in Figure 9.7. For a funny, fast-paced overview of fungi, watch this video: . MEDIA Click image to the left or use the URL below. URL: For a long time, scientists classified fungi as members of the Plant Kingdom. Fungi share several obvious traits with plants. For example, both fungi and plants lack the ability to move. Both grow in soil, and both have cell walls. Some fungi even look like plants. Today, fungi are no longer classified as plants. We now know that they have important traits that set them apart from plants. Thats why they are placed in their own kingdom. How do fungi differ from plants? The cell walls of fungi are made of chitin. Chitin is a tough carbohydrate that also makes up the outer skeleton of insects. The cell walls of plants are made of cellulose. Fungi are heterotrophs that absorb food from other organisms. Plants are autotrophs that make their own food. The Fungus Kingdom is large and diverse. It may contain more than a million species. However, fewer than 100,000 species of fungi have been identified. The earliest fungi evolved about 600 million years ago. They lived in the water. Fungi colonized the land around the same time as plants. That was probably between 400 and 500 million years ago. After that, fungi became very abundant on land. By 250 million years ago, they may have been the dominant life forms on land. Yeasts grow as single cells. Other fungi grow into multicellular, thread-like structures. These structures are called hyphae (hypha, singular). You can see a photo of hyphae in Figure 9.8. They resemble plant roots. Each hypha consists of a group of cells surrounded by a tubular cell wall. A mass of hyphae make up the body of a fungus. The body is called the mycelium (mycelia, plural). A mycelium may range in size from microscopic to very large. In fact, the largest living thing on Earth is the mycelium of a single fungus. Nicknamed the humongous fungus, it grows in a forest in Oregon. A small part of the fungus is pictured in Figure 9.9. The giant fungus covers an area of 2384 acres. Thats about the size of 1,665 football fields! The fungus is estimated to be at least 2400 years old, but it could be much older. Most fungi reproduce both asexually and sexually. In both types of reproduction, they produce spores. A spore is a special reproductive cell. When fungi reproduce asexually, they can spread quickly. This is good when conditions are stable. They can increase their genetic variation by sexual reproduction. This is beneficial when conditions are changing. Variation helps ensure that at least some organisms survive the changing conditions. Figure 9.10 shows how asexual and sexual reproduction occur in fungi. Refer to the figure as you read about each of them below. During asexual reproduction, fungi produce haploid spores by mitosis of a haploid parent cell. A haploid cell has just one of each pair of chromosomes. The haploid spores are genetically identical to the parent cell. Spores may be spread by moving water, wind, or other organisms. Wherever the spores land, they will develop into new hyphae only when conditions are suitable for growth. Yeasts are an exception. They reproduce asexually by budding instead of by producing spores. An offspring cell forms on a parent cell. After it grows and develops, it buds off to form a new cell. The offspring cell is genetically identical to the parent cell. You can see yeast cells budding in Figure 9.11. Sexual reproduction also occurs in most fungi. It happens when two haploid hyphae mate. During mating, two haploid parent cells fuse. The single fused cell that results is a diploid spore. It is genetically different from both parents.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}51{"query": "SV Germania Schoneiche is a German association football club from Schoneiche in Brandenburg.", "pos": "Mandy Hering (born 11 March 1984) is a German handball player.", "neg": "Josef Marek (born 11 June 1987) is a professional Czech football player who plays for FK Viktoria Zizkov.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}52{"query": "Clostridium difficile infection (CDI) is the main cause of nosocomial diarrhea in industrialized countries and the source of a growing number of cases of diarrhea in the community. The outbreak of the hypervirulent strain belonging to ribotype 027 has increased the incidence and severity of CDI in some countries. Although CDI usually courses as a mild diarrhea it can lead to severe forms such as toxic megacolon or septic shock. One of every 2 episodes of CDI is not diagnosed in Spanish hospitals due to a lack of clinical suspicion or the use of insensitive diagnostic methods. The diagnostic techniques of choice are algorithms based on the detection of glutamate dehydrogenase and molecular detection of the genes of the toxins with or without the direct detection of the toxins. The recommended treatment for CDI depends on the type of infection and the characteristics of the patient.", "pos": "Epidemiology of Clostridium difficile is characterized by worldwide increase of C. difficile infections (CDI) and the emergence of new epidemic outbreak strains with the capacity for global spreading. Long-term local surveillance at the University of Saarland Medical Center between 2000 and 2013 shows that the incidence rate of laboratory-confirmed CDI was influenced by local epidemiology as well as by testing strategies. Since 2008, molecular typing of C. difficile was regularly performed for symptomatic hospitalized patients by surface-layer protein A sequence typing (slpAST), which is an established highly standardized technique for genotyping of C. difficile. The results were assigned to known ribotypes for better comparison to international data. It could be demonstrated that distribution of genotypes was different between age groups. Older patients were predominantly infected with ribotype 001 and 027, whereas ribotype 027 was not detected in the pediatric population. Molecular typing of German isolates sent to the advisory laboratory between 2011 and 2013 revealed that ribotype 027 is present with high percentages in most German regions except for the very North. In conclusion, optimized testing of all hospitalized patients with diarrhea should be generally implemented to avoid under-diagnosis of C. difficile infection. Ribotype 027 is highly prevalent in Germany, but its infections are restricted to older patients, while absent in children. Molecular typing of suspected hospital outbreaks and of patients with severe or recurrent disease may help to better understand virulence and epidemic spreading of C. difficile.", "neg": "With the recent introduction of inhibitors of mammalian target of rapamycin (mTOR) in oncology, distinct cutaneous and oral adverse events have been identified. In fact, stomatitis and rash are documented as the most frequent and potentially dose-limiting side effects. Clinically, mTOR inhibitor-associated stomatitis (mIAS) more closely resembles aphthous stomatitis than oral mucositis due to conventional anticancer therapies. While most cases of mIAS are mild to moderate and self-limiting, more severe and persistent mIAS can become a dose-limiting toxicity. Small ulcerations may cause significant pain and mucosal sensitivity may occur in the absence of clinical changes. Use of clinical assessment tools that are primarily driven by ulceration size may underestimate mIAS, and assessment should include patient-reported outcomes. This article provides an up-to-date review of the clinical presentation, terminology, pathogenesis, assessment and management of mIAS and other mTOR inhibitor-associated oral adverse events. In addition, areas of future research are considered.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}53{"query": "Murat Ozcelik (born 1 January 1954) is a Turkish politician, civil servant and diplomat from the Republican People's Party (CHP), who has served as a Member of Parliament for Istanbul's third electoral district since 7 June 2015.", "pos": "Reza Rezaee (Persian: ; born December 24, 1960) is a Norwegian-Iranian politician representing the left-wing political party Red.", "neg": "Georges Bach (born 12 June 1955 in Luxembourg) is a Member of the European Parliament since 2009, representing the Christian Social People's Party in Luxembourg and the European People's Party group.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}54{"query": "In 1509, Diogo Lopes de Sequeira was sent to Malacca by the king of Portugal with four ships in order to establish contact with the Sultanate of Malacca. Initially, Sequeira was well received by the Sultan Mahmud Syah . Soon however, the Muslim community convinced Mahmud Syah that the Portuguese should be eliminated. Several men were captured and killed, but the ships escaped. Albuquerque first departed from India for Malacca in April 1511, with 1,200 men and 17 to 18 ships. Albuquerque's objective was to sever Islamic trade and Venetian trade on the same occasion.A first attack by the Portuguese failed on 25 July 1511. Albuquerque's captains spoke against another attempt, but he struck again, succeeding in capturing Malacca in August, despite strong resistance and the presence of artillery on the Malaccan side. In celebration, Tristao da Cunha was sent to Pope Leo X in Rome with rich presents including the elephant that the pope named Hanno.", "pos": "The Conquest of Melilla occurred in September 1497, when a fleet sent by the Duke of Medina Sidonia seized the north African city of Melilla., as continuation of Reconquest of Mauritania Tingitana During the 15th century the mediterranean cities of the Sultanate of Fez fell in decadence in opposition to cities located in the Atlantic facade, which concentrated most of the economic activity. By the end of the 15th century, the port of Melilla, that had been often disputed between the rulers of Fez and Tlemcen, was nearly abandoned. Plans for the conquest occurred as soon as the Fall of Granada in 1492. Spanish captains Lezcano and Lorenzo Zafra visited the coast of Northern Africa to identify possible locations for the Spanish to overtake, and Melilla was identified as a prime candidate. Melilla was, however, in the Portuguese zone of influence under the terms of the 1479 Treaty of Alcacovaz. At Tordesillas in 1494, King John II of Portugal, the Portuguese ruler agreed to make an exception and permitted the Spanish to attempt the conquest of Melilla. The duke sent Pedro Estopinan who conquered the city virtually without a fight in 1497, as internal conflicts had depleted it of troops, and its defenses were weakened. The Wattasid ruler Muhammad al-Shaykh sent a detachment of cavalrymen to retake control of the city, but they were repulsed by the guns of the Spanish ships.", "neg": "In the Atlantic, the West India Company concentrated on wresting from Portugal its grip on the sugar and slave trade, and on opportunistic attacks on the Spanish treasure fleets on their homeward bound voyage. Bahia on the north east coast of Brazil was captured in 1624 but only held for a year before it was recaptured by a joint Spanish-Portuguese expedition. In 1628, Piet Heyn captured the entire Spanish treasure fleet, and made off with a vast fortune in precious metals and goods that enabled the Company two years later to pay its shareholders a cash dividend of 70%, though the Company was to have relatively few other successes against the Spanish. In 1630, the Dutch occupied the Portuguese sugar-settlement of Pernambuco and over the next few years pushed inland, annexing the sugar plantations that surrounded it. In order to supply the plantations with the manpower they required, a successful expedition was launched in 1637 from Brazil to capture the Portuguese slaving post of Elmina, and in 1641 successfully captured the Portuguese settlements in Angola. In 1642, the Dutch captured the Portuguese possession of Axim in Africa. By 1650, the West India Company was firmly in control of both the sugar and slave trades, and had occupied the Caribbean islands of Sint Maarten, Curacao, Aruba and Bonaire in order to guarantee access to the islands' salt-pans.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}55{"query": "DNA and RNA are nucleic acids. DNA stores genetic information. RNA helps build proteins. Proteins, in turn, determine the structure and function of all your cells. Proteins consist of chains of amino acids. A proteins structure and function depends on the sequence of its amino acids. Instructions for this sequence are encoded in DNA. In eukaryotic cells, chromosomes are contained within the nucleus. But proteins are made in the cytoplasm at structures called ribosomes. How do the instructions in DNA reach the ribosomes in the cytoplasm? RNA is needed for this task. RNA stands for ribonucleic acid. RNA is smaller than DNA. It can squeeze through pores in the membrane that encloses the nucleus. It copies instructions in DNA and carries them to a ribosome in the cytoplasm. Then it helps build the protein. RNA is not only smaller than DNA. It differs from DNA in other ways as well. It consists of one nucleotide chain rather than two chains as in DNA. It also contains the nitrogen base uracil (U) instead of thymine (T). In addition, it contains the sugar ribose instead of deoxyribose. You can see these differences in Figure 5.16. There are three different types of RNA. All three types are needed to make proteins. Messenger RNA (mRNA) copies genetic instructions from DNA in the nucleus. Then it carries the instructions to a ribosome in the cytoplasm. Ribosomal RNA (rRNA) helps form a ribosome. This is where the protein is made. Transfer RNA (tRNA) brings amino acids to the ribosome. The amino acids are then joined together to make the protein. How is the information for making proteins encoded in DNA? The answer is the genetic code. The genetic code is based on the sequence of nitrogen bases in DNA. The four bases make up the letters of the code. Groups of three bases each make up code words. These three-letter code words are called codons. Each codon stands for one amino acid or else for a start or stop signal. There are 20 amino acids that make up proteins. With three bases per codon, there are 64 possible codons. This is more than enough to code for the 20 amino acids plus start and stop signals. You can see how to translate the genetic code in Figure 5.17. Start at the center of the chart for the first base of each three-base codon. Then work your way out from the center for the second and third bases. Find the codon AUG in Figure 5.17. It codes for the amino acid methionine. It also codes for the start signal. After an AUG start codon, the next three letters are read as the second codon. The next three letters after that are read as the third codon, and so on. You can see how this works in Figure 5.18. The figure shows the bases in a molecule The genetic code has three other important characteristics. The genetic code is the same in all living things. This shows that all organisms are related by descent from a common ancestor. Each codon codes for just one amino acid (or start or stop). This is necessary so the correct amino acid is always selected. Most amino acids are encoded by more than one codon. This is helpful. It reduces the risk of the wrong amino acid being selected if there is a mistake in the code. The process in which proteins are made is called protein synthesis. It occurs in two main steps. The steps are transcription and translation. Watch this video for a good introduction to both steps of protein synthesis: [Link] MEDIA Click image to the left or use the URL below. URL: Transcription is the first step in protein synthesis. It takes place in the nucleus. During transcription, a strand of DNA is copied to make a strand of mRNA. How does this happen? It occurs by the following steps, as shown in Figure 5.19. 1. An enzyme binds to the DNA. It signals the DNA to unwind. 2. After the DNA unwinds, the enzyme can read the bases in one of the DNA strands. 3. Using this strand of DNA as", "pos": "DNA is the material that makes up our chromosomes and stores our genetic information. When you build a house, you need a blueprint, a set of instructions that tells you how to build. The DNA is like the blueprint for living organisms. The genetic information is a set of instructions that tell your cells what to do. DNA is an abbreviation for deoxyribonucleic acid. As you may recall, nucleic acids are a type of macromolecule that store information. The deoxyribo part of the name refers to the name of the sugar that is contained in DNA, deoxyribose. DNA may provide the instructions to make up all living things, but it is actually a very simple molecule. DNA is made of a very long chain of nucleotides. In fact, in you, the smallest DNA molecule has well over 20 million nucleotides. Nucleotides are composed of three main parts: 1. a phosphate group. 2. a 5-carbon sugar (deoxyribose in DNA). 3. a nitrogen-containing base. The only difference between each nucleotide is the identity of the base. There are only four possible bases that make up each DNA nucleotide: adenine (A), guanine (G), thymine (T), and cytosine (C). The various sequences of the four nucleotide bases make up the genetic code of your cells. It may seem strange that there are only four letters in the alphabet of DNA. But since your chromosomes contain millions of nucleotides, there are many, many different combinations possible with those four letters. But how do all these pieces fit together? James Watson and Francis Crick won the Nobel Prize in 1962 for piecing together the structure of DNA. Together with the work of Rosalind Franklin and Maurice Wilkins, they determined that DNA is made of two strands of nucleotides formed into a double helix, or a two-stranded spiral, with the sugar and phosphate groups on the outside, and the paired bases connecting the two strands on the inside of the helix (Figure 1.1). The bases in DNA do not pair randomly. When Erwin Chargaff looked closely at the bases in DNA, he noticed that the percentage of adenine (A) in the DNA always equaled the percentage of thymine (T), and the percentage of guanine (G) always equaled the percentage of cytosine (C). Watson and Cricks model explained this result by suggesting that A always pairs with T, and G always pairs with C in the DNA helix. Therefore A and T, and G and C, are \"complementary bases,\" or bases that always pair together, known as a base-pair. The base-pairing rules state that A will always bind to T, and G will always bind to C (Figure 1.2). For example, if one DNA strand reads ATGCCAGT, the other strand will be made up of the complementary bases: TACGGTCA. Hydrogen bonds hold the complementary bases together, with two bonds forming between an A and a T, and three bonds between a G and a C. The chemical structure of DNA includes a chain of nucleotides consisting of a 5- carbon sugar, a phosphate group, and a nitrogen base. Notice how the sugar and phosphate group form the backbone of DNA (strands highlighted in pink), with the hydrogen bonds between the bases joining the two strands.", "neg": "Organic molecules must also carry out the chemical work of cells; that is, their metabolism. Chemical reactions in a living organism allow that organism to live in its environment, grow, and reproduce. Metabolism gets energy from other sources and creates structures needed in cells. The chemical reactions occur in a sequence of steps known as metabolic pathways. The metabolic pathways are very similar between unicellular bacteria that have been around for billions of years and the most complex life forms on Earth today. This means that they evolved very early in Earths history. Living cells need organic molecules, known as nucleic acids, to store genetic information and pass it to the next generation. Deoxyribonucleic acid (DNA) is the nucleic acid that carries information for nearly all living cells today and did for most of Earths history. Ribonucleic acid (RNA) delivers genetic instructions to the location in a cell where protein is synthesized. Many scientists think that RNA was the first replicator. Since RNA catalyzes protein synthesis, most scientists think that RNA came before proteins. RNA can also encode genetic instructions and carry it to daughter cells, such as DNA. The idea that RNA is the most primitive organic molecule is called the RNA world hypothesis, referring to the possibility that the RNA is more ancient than DNA. RNA can pass along genetic instructions as DNA can, and some RNA can carry out chemical reactions like proteins can. Click image to the left or use the URL below. URL: Pieces of many scenarios can be put together to come up with a plausible suggestion for how life began. Click image to the left or use the URL below. URL:", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}56{"query": "The Patriots faced the Dolphins at home looking not only for revenge, but to clinch the AFC East for the sixth straight season. On the opening drive of the game, the Dolphins raced 57 yards in just 5 plays, all the way to the Patriots 23, setting up a 41-yard field goal attempt by Caleb Sturgis, but Jamie Collins blocked it, Kyle Arrington picked it up and raced 62 yards for a touchdown. After a Dolphins punt, the Pats drove 42 yards to the Dolphins 38, but Brady was intercepted by Jason Trusnik at the 34. The Dolphins drove 60 yards to the Patriots 6, but the red zone defense forced them to kick a 24-yard field goal. After a Patriots punt, the Dolphins drove to their own 45, but Ryan Tannehill was intercepted by Duron Harmon at the Patriots 34 and returned the ball 60 yards to the Dolphins 8. Three plays later, Shane Vereen ran in a 3-yard touchdown, increasing the lead to 14-3. Jarvis Landry returned the ensuing kick 26 yards to the Dolphins 37. They drove 38 yards to the Patriots 35, but Sturgis kicked a 53-yard field goal. After the next three drives ended in punts, with the first half winding down, Tannehill connected with Wallace on a 32-yard touchdown bomb with 0:05 left to trim the score to 14-13 on a play that was initially ruled a drop. After a decent offensive showing in the first half, the Patriots went on a barrage of scoring in the third quarter. After returning the kickoff 19 yards to the 21, the Patriots stormed 79 yards in just 8 plays, increasing their lead to 21-13 on LeGarrette Blount's 3-yard touchdown run. After a Dolphins three-and-out, the Patriots drove 47 yards to the Dolphins 17 where Gostkowski drilled a 35-yard for goal, increasing the lead to 24-13. Patrick Chung intercepted a pass on the first play of the next drive and returned it 10 yards to the Dolphins 27. The Patriots cashed it in for a touchdown on the first play with Brady air mailing a 27-yard touchdown strike to Rob Gronkowski, upping the lead to 31-13. After another Dolphins three-and-out, the Patriots need just three plays to put the game on ice. First Jonas Gray ran for 6 yards to the Dolphins 41, followed by Brady hooking up with Gronkowski for 35 yards to the Patriots 6. Brady then found Edelman for the 6-yard touchdown pass on the next play, making the score 38-13. The Dolphins drove 65 yards in 14 plays to the Patriots 25, but on 4th-and-18, Daniel Thomas could only gain 10 yards and the Dolphins turned the ball over on downs. The Patriots scored the final points on a 36-yarder, making the score 41-13. The Dolphins turned the ball over on downs and the Patriots took a knee to end the game. The Patriots offensive line was immensely better than the opening day game against Miami as Brady wasn't sacked at all. Brady tossed 2 TDs to Edelman and Gronkowski while Vereen and Blount picked up rushing TDs. Gronkowski was their leading receiver with 96 yards and 1 touchdown on just 3 catches, and in the process secured his second 1,000 yard season. Miami picked up 384 yards of offense, but mostly couldn't get out of their own way with two turnovers and some awful drops, including a dropped touchdown by Mike Wallace. With the blowout win, the Patriots improved to 11-3, clinching their 17th AFC East title in franchise history, the 12th in the Brady-Belichick era, and their 6th straight.", "pos": "The Patriots faced the Denver Broncos in a rematch of the previous season's AFC Championship game. The Broncos won the coin toss and elected to kick. Beginning at their own 24, the Patriots went were unable to get a first down causing them to punt. Unluckily for the Broncos, during Ryan Allen's punt Jordan Norwood muffed the punt and the Patriots obtained it with a Jonathan Jones recovery. The Patriots began at the Denver 31. Unfortunately for the Patriots, they were unable to get a first down and were forced to settle with a Stephen Gostkowski 45-yard field goal for 3 points. The Broncos began the ball on their own 25 on the next possession. They started off well with a 13-yard run by Justin Forsett. However, they were unable to get a first down. On the Patriots next drive, they began at their own 15. On the beginning of the first play, an illegal formation was called on the Patriots forcing them to move back 5-yards. Once again, they went three and out unable to acquire a first down. The Patriots punted and the Broncos began at their own 38. This time, they managed to get a field goal with Brandon McManus's 33-yard kick. They traveled 47-yards in 8 plays and 2:55. The next Patriots drive would once again end in a punt but this time traveling 31 yards on 6 plays. The Broncos received the punt at their own 7. This time, they managed to get to the Patriot's red zone nearly getting into the end zone. Nonetheless, Trevor Siemian was intercepted by Logan Ryan on a pass intended for Emmanuel Sanders. Ryan ran the ball back all the way to the Denver' 46. This was the first play of the second quarter. This time the Patriots managed to get a touchdown in spite of the fact that they had to face a 1st & 20. They first play of the drive ending in a Tom Brady fumble in which Patriot offensive lineman Joe Thuney recovered. The Patriots reached the Broncos' 1 and scored a touchdown with LeGarrette Blount's 1-yard run. The next 2 drives of both teams ended in punts. The Broncos received the ball once more and ended the first half with a run play. The Broncos began with first possession in the beginning of the second half. On their first drive, they went three and out having to punt. Similarly, the Patriots also went three and out. On the next Broncos' possession once again, they were unable to get a first down. The Patriots managed to score on their next drive with Gostkowski's 40-yard field goal. They went 11 plays for 61 yards in 5:12. The next 5 incoming drives all ended in punts. The next few points would come in another Gostkowski field goal at 21-yards. The next 2 drives would end in downs. McCourty stripped Jordan Norwood with a few seconds left to seal the win. Despite just sixteen completions for 188 yards Brady defeated the Broncos for only the third time at Denver and seventh time in his career With the win, the Patriots improved to 12-2, and they clinched a first round bye for the playoffs and the AFC East title for the eighth straight season. Their eighth straight division title surpassed the Rams franchise from 1973-79 for the most consecutive division titles won by one team in NFL history.", "neg": "This game is well known for an infamous penalty that occurred during the overtime period. The Jets were lining up for a game winning 56-yard field goal in overtime to try and give them the win. Nick folk kicked the ball, but the kick went wide right and the Patriots appeared to be taking over with a chance to win. However, Chris Jones of New England was called for a controversial unsportsmanlike conduct penalty after pushing his teammate into the offensive line. This penalty would later be named \"leaping\". The penalty gave the Jets another chance and made the field goal attempt a 51-yard attempt. This time, Folk drilled the kick, and the Jets would go on to stun the Patriots. With the win, the Jets improved to 4-3.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}57{"query": "The apolipoprotein E (APOE) 4 allele has been implicated in a range of neuropsychiatric conditions. The present research examined if the 4 allele of the APOE gene moderated the effect of combat exposure on posttraumatic stress disorder (PTSD) among Iraq/Afghanistan-era veterans. Participants included 765 non-Hispanic White (NHW) and 859 non-Hispanic Black (NHB) Iraq/Afghanistan-era veterans. A structured interview established psychiatric diagnoses. Combat exposure and PTSD symptom severity were assessed via self-report. The most common lifetime diagnoses were depression (39.2%), PTSD (38.4%), and alcohol dependence (24.38%). After correcting for multiple comparisons, no significant effects were observed on any of the outcomes among the NHW sample; however, within the NHB sample, significant gene environment (G E) interactions were observed for lifetime PTSD (P = .0029) and PTSD symptom severity (P = .0009). In each case, the APOE 4 allele had no effect on the outcomes when combat exposure was low; however, when combat exposure was high, an additive effect was observed such that 4 homozygotes exposed to high levels of combat reported the highest rates of PTSD (92%) and the worst symptom severity scores on the Davidson Trauma Scale (M = 79.5). Although preliminary, these findings suggest that the APOE 4 allele, in conjunction with exposure to high levels of combat exposure, may increase veterans' risk for developing PTSD.", "pos": "This report describes the reliability, validity, treatment sensitivity, diagnostic performance and normative values for the Short Post-Traumatic Stress Disorder (PTSD) Rating Interview (SPRINT), a brief, global assessment for PTSD. The SPRINT was administered to subjects participating in a clinical trial of PTSD and in a population survey assessing PTSD prevalence. The 8-item SPRINT includes questions assessing the core symptoms of PTSD, as well as related aspects of somatic malaise, stress vulnerability and functional impairment. Validity was assessed against the MINI structured interview, the Davidson Trauma Scale, Treatment Outcome for PTSD Scale, Connor-Davidson Resilience Scale, Sheehan Stress Vulnerability Scale, Sheehan Disability Scale and Clinical Global Impressions of Severity and Improvement Scales. Good test-retest reliability, internal consistency, convergent and divergent validity were obtained. The SPRINT was responsive to symptom change over time and correlated with comparable PTSD symptom measures. In victims of trauma, a score of 14-17 was associated with 96% diagnostic accuracy, whereas in those with PTSD, highest efficiency corresponded to a range of 11-13. The SPRINT demonstrates solid psychometric properties and can serve as a reliable, valid and homogeneous measure of PTSD illness severity and of global improvement.", "neg": "Baghdad, in 2004, three soldiers of an Army bomb-disposal unit are investigating a report of an improvised explosive device (IED). They use a sophisticated robot drone to examine the device, which consists of several undetonated artillery shells wired together and hidden under plastic/fabric sheets. The unit, led by Sgt. Thompson, decides that they can detonate the IED using plastic explosives that they'll activate from a safe distance. Thompson also says that the explosion won't cause very much property damage and should result in no loss of life.A small cart is affixed to the back of the robot, which is then sent back into the blast zone. Before it can reach the IED, the trailer loses a wheel. Thompson dresses in a bulky bomb suit and walks down to the trailer. He picks it up and carries it to the IED, rigging it properly. As he walks back, his partners, Sgt. Sanborn and Specialist Eldridge, scan the immediate area for anyone they consider suspicious or who may be in the blast zone. When Thompson is about 25 meters from the bomb, but still in the kill zone, Eldridge notices a man running a butcher shop who is using a cellular phone. Eldridge yells to Sanborn and the specialist begins to run toward the man, ordering him to drop his phone. Sanborn tells Eldridge to shoot the man, who presses a sequence of numbers on the phone. The bomb detonates with Thompson still in the kill zone. The overpressure from the bomb kills Thompson despite the bomb suit; a large splash of blood hits the inside of the clear visor on his helmet.Thompson's body is packed into a coffin for shipment home, Sanborn supervises the procedure. He looks over Thompson's possessions for a few moments before the coffin is sealed. Back at the base, Eldridge is sitting in the rec room when the base psychologist, Lt. Col. Cambridge walks in and asks Eldridge how he's feeling (in the wake of Thompson's death). Eldridge is still clearly upset over the incident; he dry fires his rifle several times, suggesting that if he'd shot the man with the cell phone, Thompson might still be alive.A new leader for the team, Sgt. William James, arrives at the base. Sanborn meets him at his housing unit, where James is taking the plywood covers off his windows. When Sanborn suggests that James keep them on because of mortar shrapnel, James tells him that they won't be any good anyway if a mortar shell crashes in through the unit's roof.The next day the team responds to a report of another IED on a narrow street in the city. After the initial investigation, where they link up with the Army platoon that reported the bomb, James is dressed up in a suit similar to the one Thompson wore previously. As James approaches the bomb site, he tosses a smoke grenade, which agitates Sanborn, who can't see James to instruct him further. James also is uncommunicative with his team members, another factor that Sanborn does not appreciate. James finds an artillery shell buried under a small pile of trash. He disarms it easily, and then notices a secondary wire leading away from it. He uncovers the cable and finds it connects to a junction of six more cables. When James pulls on the junction connector, six more shells are uncovered. Another cable leads to a nearby building. James disarms the six new shells; as he does, he notices a man quickly leaving the building, presumably the bomber. James flashes one of the small detonators from one of the shells and smiles at the man, who vanishes from sight. Back at their Humvee, Sanborn tells James that he needs to communicate more during operations and not treat his duty as if it's a solo act. James brushes his teammate off. James does the same later when he and Sanborn talk while grooming themselves for another day's work in the latrine.The team is again called out for another bomb threat. This time, the bomb is in a car parked in front of a United Nations building. When the building is evacuated, James dons", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}58{"query": "Willis-Ekbom disease/restless legs syndrome (WED/RLS) seems to be a frequent cause of intractable chronic insomnia (ICI) but is under-recognized in children/adolescents with neurodevelopmental conditions (NDCs), as many patients do not have the ability to express the underlying \"urge-to-move\". In light of this, we aim to develop a protocol for behavioral observations supporting the diagnosis of WED/RLS. We investigated 26 pediatric patients (age 1-16 years, median 8) with NDCs, ICI and evidence of familial WED/RLS employing (1) \"emplotted narratives\" for description of the various \"urge-to-move\" presentations and (2) self-description and \"behavioral observations\" during a \"suggested clinical immobilization test\" (SCIT). Parental narratives reflected typical WED/RLS-related \"urge-to-move\" symptoms during day-, bed-, and nighttime in all patients. Fifteen out of 26 patients could describe the \"urge-to-move\" during the SCIT. Ten out of 26 patients, unable to describe their symptoms due to cognitive disabilities, showed patterns of \"relieving-movements\" upon observation. Sensory processing abnormalities were reported in all patients, with tactile sensitivities (26/26) (including shifted pain threshold) as the most common sensory domain. \"Emplotted narratives\" and structured \"behavioral observations\" support recognition of familial WED/RLS associated movement patterns and provide a useful tool for the diagnosis of WED/RLS in children with NDCs in a clinical office setting.", "pos": "Restless legs syndrome (RLS), also known as Willis-Ekbom disease, is characterised by abnormal sensations in the legs as well as dysaesthesia. Although the aetiology of RLS has not yet been determined, it may be associated with systemic inflammation. The neutrophil-to-lymphocyte ratio (NLR) is a new and simple marker indicating systemic inflammation. The present study aimed to investigate the relationship between systemic inflammation and RLS through the use of the NLR. A total of 75 newly diagnosed patients with RLS and 56 healthy control subjects were included in the study. Baseline NLR was calculated by dividing the absolute neutrophil count by the absolute lymphocyte count. The NLRs of the two groups were compared. There were no significant differences in gender and age between the two groups. The NLR was 1.96 0.66 in the patient group and 1.67 0.68 in the control group (p = 0.005). Receiver operating characteristic analysis was performed to determine the cut-off value of NLR to predict RLS. The NLR was predictive at 1.58 with a 64% sensitivity and 50% specificity (95% confidence interval 0.55-0.74, area under curve 0.648 0.05). The NLR was found to be statistically higher in patients with RLS and may be used to predict RLS. The aetiology of RLS remains undetermined. The present study showed that systemic inflammation may play a role in RLS. However, RLS could also be associated with systemic inflammatory diseases. This relationship is supported by high NLR values, which are related to chronic systemic inflammation.", "neg": "Increased expression of nerve growth factor in injured or inflamed tissue is associated with increased pain. This proof-of-concept study was designed to investigate the safety and analgesic efficacy of tanezumab, a humanized monoclonal antibody that binds and inhibits nerve growth factor. We randomly assigned 450 patients with osteoarthritis of the knee to receive tanezumab (administered at a dose of 10, 25, 50, 100, or 200 g per kilogram of body weight) or placebo on days 1 and 56. The primary efficacy measures were knee pain while walking and the patient's global assessment of response to therapy. We also assessed pain, stiffness, and physical function using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC); the rate of response using the criteria of the Outcome Measures for Rheumatology Committee and Osteoarthritis Research Society International Standing Committee for Clinical Trials Response Criteria Initiative (OMERACT-OARSI); and safety. When averaged over weeks 1 through 16, the mean reductions from baseline in knee pain while walking ranged from 45 to 62% with various doses of tanezumab, as compared with 22% with placebo (P<0.001). Tanezumab, as compared with placebo, was also associated with significantly greater improvements in the response to therapy as assessed with the use of the patients' global assessment measure (mean increases in score of 29 to 47% with various doses of tanezumab, as compared with 19% with placebo; P0.001). The rate of response according to the OMERACT-OARSI criteria ranged from 74 to 93% with tanezumab treatment, as compared with 44% with placebo (P<0.001). The rates of adverse events were 68% and 55% in the tanezumab and placebo groups, respectively. The most common adverse events among tanezumab-treated patients were headache (9% of the patients), upper respiratory tract infection (7%), and paresthesia (7%). In this proof-of-concept study, treatment with tanezumab was associated with a reduction in joint pain and improvement in function, with mild and moderate adverse events, among patients with moderate-to-severe osteoarthritis of the knee. (Funded by Rinat Neuroscience; ClinicalTrials.gov number, NCT00394563.).", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}59{"query": "Playing in their second game of the season, the Cincinnati Bengals had a lot of things go wrong. Playing Ohio state rivals Cleveland Browns, the defense looked the exact opposite as they did in week one. Browns quarterback Derek Anderson started and threw for 328 yards and five touchdowns. It was only the third time in NFL history that two quarterbacks had thrown at least five touchdown passes in the same game. Jamal Lewis had 215 yards rushing with one touchdown and the Browns had two receivers with over 100 yards, Braylon Edwards and Kellen Winslow. The Bengals offense tried their best to keep the team in the game, however, as Carson Palmer threw for 6 TD's and Chad Johnson caught for 209 yards. The game started out slowly in the first quarter but the second quarter saw a combined 35 points scored. It was close in the end, when the Bengals started a drive with under one minute left. They managed to get the ball to the 50-yard line when Carson Palmer was intercepted by Leigh Bodden on an intended pass for Chad Johnson. This game ended up being the eighth highest scoring game in NFL history, but not the highest scoring game between these two teams. In 2004, the Bengals beat the Browns 58-48 for the second-most combined points. The Redskins (72) and Giants (41) combined for 113 points in 1966 for the most. Q1 - CIN - 10:40 - 13-yard TD pass from Carson Palmer to Rudi Johnson (Shayne Graham kick) (CIN 7-0) Q1 - CLE - 5:02 - Phil Dawson 39-yard FG (CIN 7-3) Q1 - CLE - 0:09 - Phil Dawson 39-yard FG (CIN 7-6) Q2 - CLE - 11:02 - 17-yard TD pass from Derek Anderson to Joe Jurevicius (Dawson kick) (CLE 13-7) Q2 - CIN - 7:40 - 23-yard TD pass from Carson Palmer to T. J. Houshmandzadeh (Graham kick) (CIN 14-13) Q2 - CLE - 6:37 - 9-yard TD pass from Derek Anderson to Joe Jurevicius (Dawson kick) (CLE 20-14) Q2 - CIN - 3:12 - 22-yard TD pass from Carson Palmer to Chad Johnson (Graham kick) (CIN 21-20) Q2 - CLE - 1:11 - 25-yard TD pass from Derek Anderson to Kellen Winslow (Dawson kick) (CLE 27-21) Q3 - CIN - 12:13 - Shayne Graham 20-yard FG (CLE 27-24) Q3 - CLE - 8:24 - 34-yard TD pass from Derek Anderson to Braylon Edwards (Dawson kick) (CLE 34-24) Q3 - CIN - 6:18 - 14-yard TD pass from Carson Palmer to Chad Johnson (Graham kick) (CLE 34-31) Q3 - CLE - 6:04 - Jamal Lewis 66-yard TD run (Dawson kick) (CLE 41-31) Q3 - CIN - 0:53 - 5-yard TD pass from Carson Palmer to T. J. Houshmandzadeh (Graham kick) (CLE 41-38) Q4 - CLE - 10:07 - 37-yard TD pass from Derek Anderson to Braylon Edwards (Dawson kick) (CLE 48-38) Q4 - CLE - 5:47 - Phil Dawson 18-yard FG (CLE 51-38) Q4 - CIN - 3:45 - 7-yard TD pass from Carson Palmer to Glenn Holt (Graham kick) (CLE 51-45)", "pos": "Hoping to maintain their winning streak, the Steelers flew to LP Field for an AFC Duel with the Titans. The Steelers wasted no time getting the early lead when on the opening kickoff, Mewelde Moore handed the ball off to rookie wide receiver Antonio Brown, who returned it 89yards for a touchdown. Tennessee would cut the lead when Rob Bironas nailed a 21-yard field goal. Throughout the rest of the game, Pittsburgh scored steadily with kicker Jeff Reed, who hit field goals of 36, 34, 25, and 27yards, putting the Steelers up 19-3. The Titans finally scored a touchdown in the fourth quarter with a Kerry Collins 2-yard pass to former Steeler Nate Washington, and successfully converted the 2-point conversion and onside kick necessary to give themselves the chance to tie the game on the final drive. However, Pittsburgh's defense was able to stop Chris Johnson on a reception as the clock ran out, sealing the victory. Starting quarterback Dennis Dixon sprained his left knee during the second quarter and was replaced by Charlie Batch, but the Steelers defense swarmed the Titans, coming up with four sacks and forcing seven turnovers, the most by Tennessee since 2000. The Titans pulled their starting QB, Vince Young, after his third turnover. After replacing Young, Kerry Collins had two turnovers of his own. Pittsburgh also ended Tennessee running back Chris Johnson's 100-yard rushing streak at 12 games. The NFL's rushing champion had a chance to move one game away from the league record of 14 held by Barry Sanders, but he finished with just 16 carries for 34yards. Steelers linebacker James Harrison had three sacks, forced a fumble and recovered another. Safety Troy Polamalu was credited for an interception and an impressive leaping tackle on Kerry Collins during an attempted goal-line stand by the Steelers to win the game and improve to 2-0.", "neg": "This game is well known for an infamous penalty that occurred during the overtime period. The Jets were lining up for a game winning 56-yard field goal in overtime to try and give them the win. Nick folk kicked the ball, but the kick went wide right and the Patriots appeared to be taking over with a chance to win. However, Chris Jones of New England was called for a controversial unsportsmanlike conduct penalty after pushing his teammate into the offensive line. This penalty would later be named \"leaping\". The penalty gave the Jets another chance and made the field goal attempt a 51-yard attempt. This time, Folk drilled the kick, and the Jets would go on to stun the Patriots. With the win, the Jets improved to 4-3.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}60{"query": "The movie opens with James Reece (Jonathan Rhys Meyers) driving through the streets of Paris in a black SUV to work. Reece works in the American Embassy as an aide to Ambassador Bennington (Richard Durden), the U.S. Ambassador to France. Taking a delivery of some forms from the Ambassador's secretary, he goes over Bennington's itinerary for the next few days, centering around a major summit in which the U.S., France, and several other nations are preparing foreign aid to the African continent. Bennington shows that he is more absorbed right now in a chess game he's playing with Reece during all this time. Despite paying less attention to the board and the game than Bennington is, Reece quickly checkmates him to win.Reece receives a call from an unknown source (voiced by David Gasman) directing him to a silver BMW in the parking lot, excusing himself with a cover story to Bennington that he has to review the Summit's planned seating arrangement. Going to the parking lot, Reece opens a code-locked security compartment in the trunk of his SUV to reveal a firearm and several French license plates. He removes the license plate from the silver BMW and replaces it with one of the plates he has stowed away in his SUV. He then moves his SUV to another parking space and waits there, watching the silver BMW. He watches several men get into the vehicle, put a briefcase into its trunk, and drive away.Arriving home, Reece gets another call from the same source. Reece is in fact a CIA operative working in the Embassy as a cover. He does minor jobs for his superiors, and is eager to move up into Special Ops. His superior assures him he'll get his chance, but for right now he is needed to secure a hidden transmission chip in the French Foreign Minister's office during a meeting with Ambassador Bennington. Reece doesn't believe he was given a chip, but is told it's in his left jacket pocket. Checking his jacket, he finds the chip there.Sitting in his apartment, Reece examines the chip. He is interrupted by a knock on his door. It's his girlfriend, Caroline (Kasia Smutnak) (pronounced Cah-roll-een, the 'ine' being pronounced like in the word 'magazine'). Caroline kisses Reece and tells him she has a surprise. She sits him in a chair and makes him keep his back to her. He can hear her undressing and changing into a different outfit. When she tells him to look, his jaw drops at the sight of her wearing a sexy strapless dress. He thinks he recognizes the fabric, and Caroline tells him she made it out of their bedroom curtains-- Caroline is a clothing designer. The two of them quickly start to undress as they head into the bedroom to make out.Reece arrives the next day at the conference site to give Bennington a summary of what is intended to be discussed at the meeting. Bennington invites Reece to attend the meeting with him.During the meeting, Reece discreetly takes the chip (disguising it by putting a piece of gum in his mouth and offering another piece to the Minister's secretary) and tries to put it under the lampstand beside his seat, using his chewing gum as an adhesive. However, the gum fails to hold and twice it falls back to the floor in plain sight. Frustrated, and barely managing to keep the chip hidden, as a diversion Reece finally questions the Foreign Minister (Eric Godon) about his having several Goyas in his office. The Minister says he does, and offers to show them to Bennington, who is very interested in Goya art. As Bennington accompanies the Minister and secretary to see the Goyas, leaving Reece alone in the meeting room, Reece takes the stapler from the Minister's desk and staples the chip to the underside of the desk... but accidentally leaves the stapler open as he exits.Arriving home that evening, Reece is disquieted as the lights in the hallway go out. He finds what looks like a trail of blood leading to a door out onto the roof of the building. Grabbing a broom left in", "pos": "The Men in Black are a secret law-enforcement agency that is responsible for policing the extraterrestrial life hidden on Earth, as well as protecting the world from any aliens who attempt to destroy/invade the planet.The film begins on LunarMax, a MiB prison situated on the moon. A one-armed criminal, a Boglodite named Boris the Animal, stages a jailbreak (along the way killing Obadiah Price, a fellow inmate he'd made a deal with). His intention is to rewrite history, with Agent K, the one who arrested and imprisoned him, being a major factor in his plan...On Earth, Agent K and his partner Agent J cover up an arrival of an alien spacecraft, and hear of the prison break. At a Chinese restaurant thats a local haunt for aliens, Agent K discovers Boris (who had previously gone to see Obadiah's son Jeffrey) and the two fight, with J joining in. K is upset that the alien he should have killed is out loose again; he deems it his own affair and forbids J to help him, suspending him. A puzzled J checks up on Boris: he appeared in 1969 to stop the prevention of the ArcNet Shield, a device that K deployed to protect the world from harm (but which killed off the Boglodites, as they can only survive by feeding off worlds). He managed to kill on 15 July 1969 an alien named Roman the Fabulous and on the following day... at this point O cuts him off and tells him not to investigate any further. That night, as K waits for Boris with a gun in his hand, he suddenly vanishes...The next morning, J discovers that he has a new partner, the liberated Agent AA, and that K has been dead for forty years (having been killed by Boris the Animal on 16th July 1969). O notices he is suffering from headaches and craves chocolate milk, which she explains are symptoms of time-fracture (aka the crime of interfering with history, which Obadiah Price was imprisoned for). At this point a Boglodite armada appears; J learns that there was nothing to hold them at bay, with no K to deploy the ArcNet. He theorizes that Boris went back in time to 1969 to kill K, thus changing history to what it was, and proposes to follow him; he heads to Jeffrey Price, who had provided Boris a time-jump device, and gets another one from him, and activates it by jumping off the Chrysler Building just as the Boglodites begin their assault...J arrives in 15 July 1969, with the intention to catch Boris as he is about to murder Roman the Fabulous. However, he is delayed from navigating the era of 1969 (most notably by an altercation with two racist cops), and gets there too late to stop Romans murder by 1969 Boris. He encounters 1969 Agent K, who subdues him and brings him to MiB headquarters. J tells K nothing, but when threatened with getting his memory erased he tells K part of the truth: he came from the future in pursuit of another time-traveler whos trying to change history.K and J follow a trail of clues to Andy Warhols Factory complex, where Warhol is revealed to be MiB Agent W. He notifies them of Griffin, an Arcanian being who has the ability to foresee all timelines and futures; Griffins planet was destroyed by the Boglodites, so he came to live on Earth and brought with him a device which will prevent the Boglodites from consuming the Earth. 1969 Boris arrives at the Factory in search of Griffin, who makes a quick exit with Boris in fast pursuit (to Js displeasure, although K doesnt seem to get too worried).J and K eventually track down Griffin at Shea Stadium, where he is foreseeing the future victory for the Mets baseball team. 1969 Boris appears and captures Griffin, but J and K are able to rescue Griffin, although Boris gets away. Griffin gives them the ArcNet and explains it can only work in zero gravity: K gets the idea to head to Cape Canaveral on 16th July 1969 (the day the Apollo 11 ship launched)", "neg": "Anna Foster (Mandy Moore) is the daughter of the President of the United States, James (Mark Harmon) and First Lady Michelle Foster (Caroline Goodall).When a hassle of Secret Service agents ruins a first date, Anna demands some freedom. Her dad agrees to send only two agents with Anna and Gabrielle La Clare (Beatrice Rosen) to a concert when Anna goes to Prague with her parents. A sexy new look for Anna causes her father to renege. When Anna discovers the concert is filled with agents and that her father has broken his promise, Gabrielle helps Anna elude her protectors. Outside the concert, Anna meets Ben Calder (Matthew Goode), and asks him to drive her to escape the agents. Anna goes to a bar with Ben and proceeds to get drunk. Unbeknownst to Anna, Ben is with the Secret Service, and tells agents Alan Weiss (Jeremy Piven) and Cynthia Morales (Annabella Sciorra) where Anna is. The President orders the three agents to have Ben guard Anna without telling her who he really is, to give her an illusion of freedom with a guarantee of safety. Believing herself free of her guards for the first time in years, Anna jumps into the Vltava River naked, mistaking it for the Danube, and Ben has to fish her out (he stays clothed). Weiss and Morales buy the camera from someone taking pictures of the skinny-dipping Anna. Anna and Ben climb a rooftop to watch an opera being shown in a plaza, where Anna eventually falls asleep with Ben guarding her, and Weiss and Morales watching from another roof.The next morning, Anna calls her parents to avoid getting into further trouble with them. Knowing she is safe, her father is initially indulgent, and Anna is about to return, but his tone changes when he is shown the photos of her nude in the river. The First Lady, however, asks, \"What happened to 'let freedom ring?'\" (That had been his earlier line when he had decided to let her stay out with Ben.) Anna is outraged at both her dad's sudden imperious tone and finding out that he traced her call. She decides to meet Gabrielle at the Love Parade in Berlin and return to her parents right before the plane trip home. Ben goes with her on the train, where they meet Scotty McGruff (Martin Hancock), a flighty romantic obsessed with Six Million Dollar Man stickers and the interconnectivity of the world, he gives them a stack of stickers and tells them to stick them up in random places, then one day when they are unhappy, they will see one and it will make them smile. Through him, the two learn that they have boarded a Venice-bound train. When they arrive in Venice, Ben calls the other agents to tell them where they are but has to leave the phone dangling when he realizes he can no longer see Anna. He finds her and McGruff getting new clothes, and the three explore Venice - until McGruff steals their wallets. Ben is about to tell the cafe they cannot pay when Anna is recognized and races off to avoid being identified as the First Daughter. Ben follows, and they tell a story of marrying, against the wishes of Anna's parents, to get a gondola ride from a kind-hearted gondolier, Eugenio (Joseph Long). Ben kisses Anna during the ride to hide her from the cafe staff's sight. Since they have no place to stay, Eugenio invites them to his and his mother Maria's (Miriam Margolyes) house. That night, thinking the kiss meant that Ben cares for her, Anna offers herself to him. To dissuade her, Ben is disingenuous and harsh. Anna finally gets in the bed alone, while Ben lies on the floor.The next day, Eugenio drives them to the Austrian border, as Weiss and Morales show up at Maria's looking for the gondolier with whom Anna and Ben were last seen. Maria tells them that Anna and Ben are married, which is reported to Anna's parents. Upset that Ben rejected her, Anna gets a ride on a truck, leaving Ben to", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}61{"query": "The first step in the management of restless legs syndrome (RLS) is to identify, and if possible to treat any condition which might cause or worsen RLS, such as iron deficiency or some drug treatments. The patients suffering from RLS should be prompted to keep a healthy sleep schedule. Drug treatment should be restricted to patients with a clear clinical diagnosis, decided on an individual basis, when the clinical impact is serious. Four drug classes are central to the treatment of RLS: dopaminergic agents, some antiepileptics, opioids, and benzodiazepines. Dopaminergic agonists are the treatment of choice, especially when daily treatment is indicated, or if the symptoms are severe. Two dopaminergic agonists are licensed in France for the treatment of RLS: ropinirole (Adartrel) and pramipexole (Sifrol). After initiation of treatment, the patients should benefit from a regular follow-up in order to evaluate the efficacy of treatment and to identify possible side-effects. Special care should be given to the detection of augmentation, a phenomenon characterized by a paradoxical worsening of the symptoms with treatment. Some particular conditions, such as RLS comorbid with renal insufficiency, during pregnancy, and in the child are discussed.", "pos": "Restless legs syndrome (RLS) is a common condition that is frequently unrecognized, misdiagnosed and poorly managed. It is characterized by uncomfortable sensations deep in the legs developing at rest that compel the person to move; symptoms are worst at night and sleep disturbance is common. RLS occurs in 7%-11% of the population in Western countries, and many such people experience troublesome symptoms. Primary RLS is familial in up to two thirds of patients. RLS may also be secondary to a number of conditions including iron deficiency, pregnancy and end-stage renal failure and, perhaps, neuropathy. Secondary RLS is most common in those presenting for the first time in later life. The pathogenesis of RLS probably involves the interplay of systemic or brain iron deficiency and impaired dopaminergic neurotransmission in the subcortex of the brain. RLS is very responsive to dopaminergic therapies. Rebound of RLS symptoms during the early morning and development of severe symptoms earlier in the day (augmentation) are problematic in those treated for a prolonged period with levodopa. Consequently, dopamine agonists have become first line treatment. Anti-convulsant medications and opioids are helpful in some patients. Correction of underlying problem wherever possible is important in the management of secondary RLS.", "neg": "Restless Legs Syndrome/Willis-Ekbom Disease (RLS/WED) is a common condition characterized by an irresistible urge to move the legs, concomitant with an unpleasant sensation in the lower limbs, which is typically relieved by movement. Symptoms occur predominantly at rest and prevail in the afternoon or evening. Treatment of patients with RLS/WED is indicated for those patients who suffer from clinically relevant symptoms. The management of mild forms of RLS/WED is mainly based on dopamine agonists (DA) therapy (including pramipexole and ropinirole) and -2- calcium-channel ligand. Nevertheless, with passing of time, symptoms tend to become more severe and the patient can eventually develop pharmacoresistance. Furthermore, long-term treatment with dopaminergic agents may be complicated by the development of augmentation, which is defined by an increase in the severity and frequency of RLS/WED symptoms despite adequate treatment. Here, we discuss which are the best therapeutic options when RLS/WED becomes intractable, with a focus on advantages and side effects of the available medications. Prevention strategies include managing lifestyle changes and a good sleep hygiene. Different drug options are available. Switching to longer-acting dopaminergic agents may be a possibility if the patient is well-tolerating DA treatment. An association with -2- calcium-channel ligand is another first-line approach. In refractory RLS/WED, opioids such as oxycodone-naloxone have demonstrated good efficacy. Other pharmacological approaches include IV iron, benzodiazepines such as clonazepam, and antiepileptic drugs, with different level of evidence of efficacy. Therefore, the final decision regarding the agent to use in treating severe RLS/WED symptoms should be tailored to the patient, taking into account the symptomatology, comorbidities, the availability of treatment and the history of the disease.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}62{"query": "Jeanne Deckers (17 October 1933 -- 29 March 1985), aka Jeannine Deckers, better known as Sur Sourire (''Sister Smile'', often credited as The Singing Nun in English-speaking countries), was a Belgian singer-songwriter and initially a member of the Dominican Order in Belgium as Sister Luc-Gabrielle.", "pos": "Agnes of Jesus, O.P., (born Agnes Galand and also known as Agnes of Langeac; November 17, 1602 -- October 19, 1634) was a French Catholic nun of the Dominican Order.", "neg": "Sigma Editions is an independent record label founded in 1998 by Rosy Parlane and Dion Workman (both ex-members of Thela).", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}63{"query": "The Niners broke the pattern of their first three games, and mounted a second half comeback to beat the Eagles (the 49ers trailed 21-10 in the second quarter). Philadelphia exploited Niner mistakes to score first half touchdowns on a blocked punt recovery, an interception return and a punt return. But the defense never allowed a point by the Eagles offense, who had led the league in scoring through the first 3 weeks of the season, and on the strength of two Colin Kaepernick touchdown passes and four Phil Dawson field goals, they took a late 26-21 lead. Late in the game the Eagles moved to the Niner one yard line, but they turned the ball over on downs, and the Niners held on for the win. The Niners outgained the Eagles 407-213, and held the ball for 42:17.", "pos": "The Jets' seventh game was an interconference duel with the Packers. Punter Steve Weatherford made the game's most controversial decision in the first quarter, opting to attempt a fake punt and run for the first down on 4th and 18. Weatherford was stopped a yard short of the first down, giving the Packers ideal field position which eventually led to an early 3-0 Packers lead. \"He does it on his own,\" Ryan said. \"(The Packers) were caving that side down. This was something Steve did on his own. I don't think he realized we'd just been sacked. We told him before that it needed to be a manageable situation, not fourth-and-20 or whatever it was.\". In a game where defense ruled, the Packers lead 3-0 at halftime. The Jets challenged a Brad Smith fumble, and lost due to his knee not being down before losing the ball. However, the Jets second challenge went to a jump ball, called an interception after Packers cornerback Tramon Williams ripped the ball out of Jerricho Cotchery's hands while they were both on the ground. The play was controversially upheld, despite the fact that the receiver appeared to be down by contact. With no challenges left, Mark Sanchez threw a ball to Dustin Keller that was ripped out of his hands and ruled an interception in the 4th quarter. The replay showed that Keller made the catch and was also down before losing possession, but with no challenges left the Jets were left with nothing. Green Bay took a 6-0 lead after the turnover. The Jets had two more chances to take the lead but had drives halted on 4th and longs. The Packers added on another field goal late to finalize a 9-0 win in the New Meadowlands Stadium. This marked the first time since 2006 the Jets were shut out.", "neg": "San Francisco kept Detroit in the game with missed opportunities, then made just enough plays for a rare two-game winning streak and its first road win. RB Frank Gore set a franchise record with 148 yards rushing in the first half and scored on a 61-yard run before leaving with a concussion. San Francisco led 13-3 at halftime after scoring on three of its first four drives, wishing it had a bigger lead after out gaining Detroit 247-102 yards and recovering a fumble without giving up a turnover. The 49ers had chances to go ahead big in the third quarter because Detroit had two turnovers on its first three plays, but they came away with only a field goal and a 13-point lead. Gore then caught a 7-yard pass, wobbled off the field and didn't return. QB Alex Smith's fumble midway through the third quarter set up a score that helped the Lions get back in the game. The 49ers drove down the field to set up K Joe Nedney's fourth field goal, a key score because it made Detroit go for a TD instead of kicking a tying field goal late in the game. S Keith Lewis intercepted QB Jon Kitna's pass at the 49ers' 2 with 2 minutes left and San Francisco now 4-5 picked up the one first down it needed to seal the game, winning consecutive games for the second time since 2003. RB Frank Gore finished with career-high 159 yards rushing and San Francisco's QB Alex Smith was 14 of 20 for 136 yards with a fumble. WR Arnaz Battle caught six passes for 55 yards, and converted a third-and-4 on the final drive to allow the 49ers to run out the clock. The 49ers' defense again came up huge, allowing only 273 total offensive yards and forcing 4 turnovers. LB Brandon Moore was yet again the story, leading the team with 9 tackles, 2 sacks and forcing 2 turnovers. With the win, the 49ers advanced to 4-5.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}64{"query": "Metabolic activation of the innate immune system governed by interleukin (IL)-1 contributes to -cell failure in type 2 diabetes. Gevokizumab is a novel, human-engineered monoclonal anti-IL-1 antibody. We evaluated the safety and biological activity of gevokizumab in patients with type 2 diabetes. In a placebo-controlled, dose-escalation study, a total of 98 patients were randomly assigned to placebo (17 subjects) or gevokizumab (81 subjects) at increasing doses and dosing schedules. The primary objective of the study was to evaluate the safety profile of gevokizumab in type 2 diabetes. The secondary objectives were to assess pharmacokinetics for different dose levels, routes of administration, and regimens and to assess biological activity. The study drug was well tolerated with no serious adverse events. There was one hypoglycemic event whereupon concomitant insulin treatment had to be reduced. Clearance of gevokizumab was consistent with that for a human IgG(2), with a half-life of 22 days. In the combined intermediate-dose group (single doses of 0.03 and 0.1 mg/kg), the mean placebo-corrected decrease in glycated hemoglobin was 0.11, 0.44, and 0.85% after 1, 2 (P = 0.017), and 3 (P = 0.049) months, respectively, along with enhanced C-peptide secretion, increased insulin sensitivity, and a reduction in C-reactive protein and spontaneous and inducible cytokines. This novel IL-1-neutralizing antibody improved glycemia, possibly via restored insulin production and action, and reduced inflammation in patients with type 2 diabetes. This therapeutic agent may be able to be used on a once-every-month or longer schedule.", "pos": "Insulin is the cornerstone of type 1 diabetes mellitus (T1DM) therapy. However, it cannot achieve a delay in the onset or evolution of this condition, while cardiovascular morbidity remains an unquestionable threat. In this review, the authors discuss gevokizumab (XOMA 052), a recombinant monoclonal antibody that can neutralize human IL-1 by binding to it. This is relevant, because this IL has been associated with -cell toxicity in both diabetes types. Moreover, gevokizumab presents two major advantages: it spares IL-1 and it exhibits favorable pharmacokinetic properties. Gevokizumab has already proven its safety and efficacy in improving glycemic control, cell function and inflammation markers in clinical trials in diabetic patients. Despite the very promising characteristics of gevokizumab, important questions remain to be answered. One important question is what to expect from a combination of this agent with insulin and if there is a subset of patients that might respond more favorably to treatment. We also need to know at what stage in the natural history of T1DM could gevokizumab be most efficacious, as well as its potential effects on cardiovascular outcomes.", "neg": "Ghrelin exhibits its biological effect through binding to the growth hormone secretagogue 1a receptor (GHS-R1a). Recently, it has been reported that ghrelin has an anti-apoptotic effect in several cell types. However, the molecule mechanisms underlying the anti-apoptotic effect of ghrelin remain poorly understood. In this study, we investigated the intracellular mechanisms responsible for anti-apoptotic effect of ghrelin on human umbilical vein endothelial cells (HUVEC). Treatment of HUVEC with ghrelin inhibited high glucose-induced cell apoptosis. Ghrelin stimulated the rapid phosphorylation of mammalian target of rapamycin (mTOR), P70S6K and S6. The GHS-R1a-specific antagonist [D-Lys3]-GHRP-6 abolished the anti-apoptotic effect and inhibited the activation of mTOR, P70S6K, S6 induced by ghrelin. Pretreatment of cells with specific inhibitor of mTOR blocked the anti-apoptotic effect of ghrelin. In addition, ghrelin protected HUVECs against high glucose induced apoptosis by increasing Bcl-2/Bax ratio. Taken together, our results demonstrate that ghrelin produces a protective effect on HUVECs through activating GHS-R1a and mTOR/P70S6K signaling pathway mediates the effect of ghrelin. These observations suggest that ghrelin may act as a survival factor in preventing HUVECs apoptosis caused by high glucose.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}65{"query": "Coming off their come-from-behind win over the Dolphins, the Broncos traveled to Arrowhead Stadium for an AFC West rematch with the Kansas City Chiefs. The Broncos jumped out to a 14-0 lead on their first two possessions in the first quarter, with quarterback Peyton Manning throwing a pair of touchdown passes a 23-yarder to wide receiver Demaryius Thomas and a 15-yarder to running back C. J. Anderson. A 22-yard field goal by placekicker Connor Barth increased the Broncos' lead to 17-0 early in the second quarter. The scoring play occurred after the Broncos' special teams fooled the Chiefs with a fake punt run by safety David Bruton and a fourth-down conversion by Anderson. The Chiefs got on the scoreboard later in the second quarter, with quarterback Alex Smith connecting on a 20-yard touchdown pass to tight end Anthony Fasano. The Broncos' offense subsequently marched down the field, but had to settle on a 24-yard field goal by Barth just before halftime. The Chiefs' defense forced a fumble off Manning deep in Broncos' territory on the Broncos' first possession of the second half, but had to settle on a 39-yard field goal by placekicker Cairo Santos. Barth added two more field goals a 30-yarder midway through the third quarter and a 33-yarder early in the fourth quarter to increase the Broncos' lead to 26-10. The first field goal came after a DeMarcus Ware interception of Smith on a deflected pass, while the second field goal came after Chiefs' cornerback Marcus Cooper muffed a punt. The Chiefs narrowed the Broncos' lead, with Smith throwing a 12-yard touchdown pass to running back Jamaal Charles. However, Broncos' safety T. J. Ward knocked away a two-point conversion pass from Smith intended for Fasano that would have brought the Chiefs to within a one-score deficit. Barth added one more field goal a 37-yarder midway through the fourth quarter. The Broncos' defense subdued the Chiefs for the remainder of the game. With the win, the Broncos swept the Chiefs for a third consecutive season. Peyton Manning improved his personal record to 11-1 all-time in games against the Chiefs.", "pos": "Coming off their last-second victory over the Bengals, the Broncos would play their Week 2 home opener against the Cleveland Browns. In the first quarter, Denver would trail early as Browns kicker Phil Dawson got a 22-yard field goal. Afterwards, the Broncos took the lead as quarterback Kyle Orton completed a 2-yard touchdown pass to tight end Tony Scheffler. Cleveland would creep close as Dawson made a 47-yard field goal, but Denver would answer as kicker Matt Prater got a 23-yard field goal in the second quarter and a 38-yard field goal in the third quarter. In the fourth, the Broncos pulled away as fullback Peyton Hillis got a 2-yard touchdown run and running back Correll Buckhalter got a 45-yard touchdown run.", "neg": "Trying to avoid a five-game losing streak, the Broncos went home for a Week 12 Interconference Duel against the New York Giants. In the first quarter the Broncos got on the board with kicker Matt Prater making a 26-yard field goal and then a 32-yard field goal in the second quarter. The Broncos kept on top with RB Knowshon Moreno making a 1-yard touchdown run. After that Matt Prater made a 47-yard field goal to end the half. In the third quarter the Giants replied with kicker Lawrence Tynes nailing a 39 then a 52-yard field goal. In the fourth quarter Denver increased their lead with QB Kyle Orton making a 17-yard touchdown pass to WR Brandon Stokley, and Prater making a 24-yard field goal.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}66{"query": "Bob and Doug McKenzie (Rick Moranis and Dave Thomas) are two dim-witted and unemployed \"hosers\" living in Toronto, Ontario who find themselves in a bind when they squander their father's beer money and then run out of beer. The brothers place a live mouse in a beer bottle in an attempt to blackmail the local beer store into giving them free Elsinore beer, but are told to take up the matter at the Elsinore brewery instead. After presenting the mouse to management at the brewery, the brothers are given jobs on the bottling line inspecting the bottles for mice. They take this opportunity to drink lots of free beer off the line; later, they present their parents with a van full of free Elsinore beer products as part of their payment with their new jobs.Meanwhile, the evil owner of the brewery, Brewmeister \"B.M.\" Smith (Max von Sydow), is perfecting a secret plan to take over the world by placing a mind-control drug in Elsinore beer which, while rendering the consumer docile, also makes him or her attack others when stimulated by certain musical tones. Smith tests this adulterated beer on patients of the conveniently located Royal Canadian Institute for the Mentally Insane, which is connected by underground tunnels to the brewery. The effects of the tainted beer are demonstrated in an extended sequence during which the mental patients don armored Star Wars-style hockey garb and, after consuming the beer, respond to synthesizer music by variously playing hockey, skating together in sync, and brawling on the ice.It seems the former brewery owner John Elsinore has recently died under mysterious circumstances and his daughter, Pam (Lynne Griffin), having recently turned 21, has been given full control of the Elsinore brewery. Pam's incompetent uncle Claude (Paul Dooley), in the interim, had married her widowed mother and is reluctant to give up his recently-gained control of the brewery. The reason for this is further revealed to be that the bumbling Claude is collaborating with Brewmeister Smith, for whom he is a buffoonish toady, providing a cover for the Brewmeister's nefarious plans. Bob and Doug blunder into the midst of these plans when they rescue Pam from a malfunctioning security gate and both become fast friends with her.While exploring the massive brewery, Bob and Doug find a shuttered cafeteria containing an old Galactic Border Patrol video game that supernaturally reveals that Brewmeister Smith murdered John Elsinore and that Uncle Claude was deeply involved. Additionally, while poking around the brewery, Bob and Doug meet a one time hockey great, Jean \"Rosie\" LeRose (Angus MacInnes), whom Bob recognizes from the hockey card he has back home at his parents' house. Having suffered a career-ending nervous breakdown and fallen under Smith's control, Rosie gets locked up at the insane asylum but is determined to fight against the Brewmeister's plot for world domination.Eventually, Bob and Doug wander into Brewmeister's operations room while he is away, and Doug takes a record disk of John Elsinore's murder, believing that it is a New Wave bootleg record. Immediately afterward, Brewmeister and Claude shoot the brothers with tranquilizers. They then dress up in the brothers clothes where they are shown on security camera shooting tranquilizer darts at Pam and a friendly associate, named Henry Green, and put their unconcious bodies in kegs.When Bob and Doug wake up, they are back in their van, convinced that their suspicious discoveries were all just dreams, and they are instructed by Claude to deliver two kegs of beer (actually containing an unconscious Pam and her father's friend, Henry Green) to a party at the bottom of a big hill. However, the brakes have been modified to only allow two stops before giving out altogether.Nevertheless, as Bob and Doug drive, they soon get distracted and decide to stop off at their house to feed their dog. They also leave behind the incriminating record disk of Brewmeister and Claude's actions at their house. Having wasted one stop prior, they find themselves unable to stop the now-speeding vehicle and eventually wind up jumping off of the Toronto pier into Lake Ontario. Rosie arrives and tries to rescue Pam who", "pos": "Mystery, Inc. goes their separate ways after becoming bored of mystery solving. Daphne Blake, along with Fred Jones, starts running a successful television series. Velma Dinkley becomes the proprietor of a mystery bookstore, and Scooby-Doo and his owner Shaggy Rogers bounce from job to job. For Daphne's birthday, Fred decides to get the gang back together for a road trip while Daphne is filming her show. After encountering a lot of fake monsters, the gang finally arrives in New Orleans. They are soon invited by a young woman named Lena Dupree to visit Moonscar Island, her employer's home, which is allegedly haunted by the ghost of the pirate Morgan Moonscar. Although the gang is skeptical, they go with Lena, to whom Fred has taken a fancy. On the island, the gang meets Lena's employer Simone Lenoir as well as the ferryman Jacques and Simone's gardener Beau, to whom Daphne takes a fancy. They also meet Snakebite Scruggs, a ill-natured fisherman, and his hunting pig, Mojo. The gang sets out to prove that the \"ghost\" is a fake. Scooby and Shaggy are chased by Mojo and end up falling into a big hole, where they encounter the zombie of Morgan Moonscar. By the time the rest of gang comes to investigate, Moonscar isn't around. Simone invites the gang to her house to stay for the night. As the gang is dressing up for dinner, Shaggy sees the ghost of a Confederate colonel in the mirror; Simone explains that the island was a temporary headquarters for a Confederate regiment during the American Civil War. Due to Simone's cats, Scooby and Shaggy eat in the Mystery Machine, but find the food spicy and get some water from the lake, where an army of zombies emerge. Shaggy's bad driving gets the Mystery Machine stuck in the mud, forcing him and Scooby to flee on foot. Fred and Daphne find the Mystery Machine, but no sign of Shaggy and Scooby. They argue about each other's supposed love interests and come across Scooby and Shaggy. They manage to capture a zombie, which is revealed to be real. As the zombies swarm around them, the gang splits in panic. Elsewhere, Scooby and Shaggy discover wax dolls that look like Fred, Velma, and Daphne, and they play with them, causing their friends to undertake a series of involuntary actions for a short time until they leave after disturbing a nest of bats. Fred, Daphne, Velma, and Beau return to Simone's house and discover a secret passage under the staircase. They find Lena, who tells them that the zombies took Simone away. Fred, Daphne, Velma, Beau, and Lena find a secret chamber for voodoo rituals, where Velma finds footprints of Simone's heels and interrogates Lena about the story. Simone then appears, and she and Lena use voodoo dolls to trap the gang in the chamber. They reveal themselves to be evil cat creatures. Simone tells them that several centuries ago, she and Lena were part of a group of settlers who were devoted to a cat god. The vengeful Lena and Simone asked their cat god to curse pirates, who had chased the settlers into the bayou. Their wish was granted and they killed the pirates, but the curse caused the duo to become cat creatures permanently, requiring that they drain life forces to preserve their immortality. They also gave Jacques immortality so they had a ferryman to bring them more victims. The zombies' intent was to warn the gang to leave to escape their fate. Jacques finds and chases Scooby and Shaggy to drain their lives, but they accidentally tumble into the cave, interrupting the draining ceremony and distracting the cat creatures. Velma quickly unties herself and creates voodoo dolls of Lena and Simone to interrupt their ritual. When they are finally cornered, the cat creatures' curse expires, causing them to disintegrate, freeing the zombies' souls to rest in peace. Beau is revealed to be an undercover police officer sent to investigate the disappearances on the island. Daphne offers Beau a chance to guest-star on her show and discuss the adventure. The next morning,", "neg": "Vince Rommel (Ross Hagen) is a good sidehacker runner. Sidehacking is a way of running motorcycle races with a passenger on the sidecar/sidehack, and Vince is supposed to be one of the best riders.Vince is in love with Rita (Diane McBain), and both like frolicking around. He asks Rita to marry him. Luke (Dick Merrifield) lost yesterday's race. His mechanic (Ivy Ross) fools around with him. J.C. (Michael Pataki) needs to have his bike ready for an exhibition fast. While the mechanic looks into the bike, Paisley (Claire Polan) talks to Rommel. He's a bit sharp towards her. J.C. notices the sidehack on the bike. Rommel explains that the passenger has to lean one way or another depending on the direction of the curve they are going through. Both the mechanic and Rommel feel that Paisley will be trouble. Dick's wife appears to ask for some money and do some shopping.J.C, Paisley, Rita and Rommel watch a race. J.C. finds it interesting. J.C. offers a position to Rommel in the exhibition, as it's very spectacular. He goes in Rommel's bike as passengers, but he falls down several times. It's good fun until Vince crashes onto a fence and sends J.C. flying. Rita looks how much Rommel and Rita a re in love. J.C. is hot-tempered and violent, and he is a cloud in the lunch everybody is enjoying. J.C. doesn't move without an entourage which tries to placate him. Nero (Edward Parrish) is the only one who tries to stand up agains her. When Rommel rejects his offer, he and his men leave the dining room. Paisley can't even remember what attracted her to him in the first place. J.C. punches her because he wants to hear her scream. J.C. that he'll kill anyone who dares to touch her; then, he says he loves her while she keeps on sobbing.Paisley, dressed to the nines, calls on Rommel at the garage some other day. He rejects her and she leaves slamming the door. Paisley cries and feels jealous of Rita and Rommel's relationship. She tears her dress to pretend that she was raped by Vince Rommel. She spills her lies as soon as J.C. comes back to their hotel room and while Rita's about to have sex with Vince. Rita dreams of her life after she's married to Vince while he falls asleep. She tenderly kisses him.J.C. interrupts them, saying \"Time's up, loverboy\". They beat and tie him up. Rita lies tied to a beam in the roof. She is dead. Vince's car has been dismantled. He runs and runs until he finds a phone booth, but he's got no money, so he keeps on running through some regional road. A car doesn't stop, so he has to keep on walking the long road. He goes to Dick and Debbie (Diane Tessier)'s, and they tend to him. Seeing Dick's children fight in a rough way, he remembers how Rita was gang-raped and killed when she was pushed around and her head hit something. Rommel can't even speak about what happened with Dick.J.C. is getting restless in his hotel room, as the police are looking for him. Dick suggests Vince to try and go on with his life. Rommel says that revenge won't change things as they are, because Rita won't be alive again anyway. They play billiards.Nero tells Rommel that there's an upcoming sidehack bike race. He will help Rommel to take his own back.Rommel prepares his revenge. He goes to the Children's Charity Workers, INC. SALVAGE shop and sells his car. Nero hires a fighting instructor. He also hires a painter who tells him that she has gone somewhere else, where there is no pain. Cooch (Michael Graham) tells him that Rommel's preparing his revenge, hiring people who can fight. Paisley tells him to leave the city and forget about it all, but J.C gets frantic. He says he was like a brother to him, and that he used", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}67{"query": "Early one morning, a taxi pulls up at Tiffany & Co. on Fifth Avenue in New York City, from which elegantly dressed Holly Golightly (Audrey Hepburn) emerges. After looking into the shop's windows, she strolls home. Outside her apartment, she fends off Sid Arbuck (Claude Stroud), her date from the disastrous night before. Later, she is awakened by new neighbor Paul Varjak (George Peppard), ringing her doorbell to get into the building. The pair chat as she dresses to leave for her weekly visit to Sally Tomato (Alan Reed), a mobster incarcerated at Sing Sing prison. Tomato's lawyer, O'Shaughnessy, pays her $100 a week to deliver \"the weather report\". Audrey Hepburn as Holly Golightly As she is leaving for Sing Sing, Holly is introduced to Paul's \"decorator\", wealthy older woman Emily Eustace Failenson (Patricia Neal), whom Paul nicknames \"2E\". That night, Holly goes out onto the fire escape to elude an over-eager date (Mel Blanc). She peeks into Paul's apartment and sees 2E leaving money and kissing Paul goodbye. After 2E leaves, Holly enters Paul's apartment and learns that he is a writer who has not had anything published since a book of vignettes five years before. Holly, in turn, explains that she is trying to save money to support her brother Fred when he gets out of the Army. The pair fall asleep, but are awakened when Holly has a nightmare about Fred. She later buys Paul a typewriter ribbon to apologize and invites him to a party at her apartment. There, Paul meets her Hollywood agent, O. J. Berman (Martin Balsam), who describes Holly's transformation from country girl into Manhattan socialite. He is also introduced to Jose da Silva Pereira (Jose Luis de Vilallonga), a wealthy Brazilian politician, and Rusty Trawler (Stanley Adams), the \"ninth richest man in America under 50.\" In the days that follow, Paul and Holly become closer. One day, 2E enters Paul's apartment, worried that she is being followed. Paul tells her that he will investigate and eventually confronts Doc Golightly (Buddy Ebsen), Holly's estranged husband. Doc explains that Holly's real name is Lula Mae Barnes. They married when she was 13, and he wants to take her back to Texas, as Fred will be returning. After Paul reunites Holly and Doc, she tells Paul the marriage was annulled. At the bus station, she tells Doc she is not going with him. Doc leaves broken-hearted. After drinking at a club, Paul and Holly return to her apartment, where she drunkenly tells him that she plans to marry Trawler for his money. A few days later, Paul learns that one of his short stories will be published. On the way to tell Holly, he sees a newspaper headline stating that Trawler has married someone else. Holly and Paul agree to spend the day together, taking turns doing things that each has never done before. At Tiffany's, Paul has the ring from Doc Golightly's box of Cracker Jack engraved as a present for Holly. After spending the night together, he awakens to find her gone. When 2E arrives, Paul ends their relationship. She calmly accepts, having earlier concluded that he and Holly are in love. Holly schemes to marry Jose for his money, which angers Paul. After Holly receives a telegram notifying her of Fred's death, she trashes her apartment. Months later, Paul has moved out. He is invited to dinner by Holly, who is leaving the next morning for Brazil to continue her relationship with Jose. However, they are arrested in connection with Sally Tomato's drug ring, and Holly spends the night in jail. The next morning, Holly is released on bail and finds Paul waiting, and they take a cab. He has her cat and a letter from Jose explaining he must end their relationship due to her arrest. Holly insists she will go to Brazil anyway, asks the cab to pull over, and releases the", "pos": "As elderly people go about their day in Manhattan, Harry walks along a sidewalk with his tabby cat Tonto on a leash, quoting Shakespeare's \"King Lear\" as he goes. Harry stops in at a grocer, buys some good food for his cat, and jokes that his sexual days are over.Next Harry meets his old friend Jacob on a bench, and tells him that his apartment building is being torn down to build a parking lot. Jacob complains about capitalists, and reassures Harry that he could always move in with him.On the way home, a kid tries to steal Harry's groceries and knocks him down. Harry is helped up by Leroy, his building super.Harry gets into his apartment and talks to Tonto, lamenting that he's been mugged four times in the past year, and that the whole city is getting run down.Some time later, police show up to forcibly remove Harry and his furniture from the building. Harry continues to spout \"King Lear\" while his son Burt arrives to pick him up.Harry goes to live with Burt and his wife and two grown sons in the suburbs. His younger grandson, Norman, has taken a vow of silence, leading to obvious tension with his brother and parents. Harry later asks Norman for the books that explain his beliefs.Harry goes back to his familiar bench to talk with Jacob, and they both agree it's been a long time since either has been with a woman. Jacob reminisces about his first sexual encounter with a servant girl when he was 14.Harry invites Leroy to dinner at Burt's house, and he plays the piano while Leroy dances to the tune. Leroy later comments that he lives with his 90-year-old mother and can't find a new job, which leads Burt's wife to question why Harry is not getting help from his two other kids.Knowing that he is a burden to Burt, Harry goes to look for his own apartment, but finds that the place he wants will not take cats. He then tells Burt he is going to Chicago to visit Shirley, Burt's sister, but before he leaves he stops at a city morgue to identify the body of Jacob, who has died with no relatives. Harry cries after recalling Jacob's story of losing his virginity.Burt takes Harry to the airport, but Harry soon learns that he can't go through security with Tonto, so he takes a cab to get a bus. Along the route, Harry asks the bus driver to stop so that Tonto can relieve himself, whereupon the cat runs away across a cemetery. The bus driver leaves Harry behind with his luggage, and when Tonto returns, Harry scolds him.Harry walks to a used car lot and buys an old Chevy for $250. He then checks into a motel and calls Burt to tell him what has happened, realizing in the process that his driver's license expired in 1958.Harry drives west rather slowly, with Tonto on the dashboard, recalling how he wanted to drive across the country when he was younger, but his wife and kids came along. He remembers they had many good times though. He confesses to Tonto that he has a great fear of pain, and that when he dies he would like to go quickly rather than the slow way his wife Annie died.Harry picks up two young hitchhikers, one of whom soon gets another ride, while the other a girl named Ginger continues west with Harry. She claims she is 16, and is running away from home to a commune in Boulder.Harry and Ginger get a motel for the night, and after she comes out of the bathroom half-naked, Harry is prompted to recall the first girl he loved, Jessie, whom he has not seen in 50 years. Ginger suggests that they go to see her, even though it's out of their way, and they eventually find her in a nursing home.At first Harry thinks Jessie remembers him, but her thoughts are marked by senility; she calls him Alex yet remembers his wife Annie. Then she suddenly asks Harry to dance, which they do while Ginger looks on.Harry", "neg": "The figure of a limp woman with long curly hair is seen drifting underwater, and a voiceover questions the end of a life that never truly existed. This life ended in murder, the victim herself unsure of who her killer was and why she was killed. Her death was only metaphorical, for in her place a new life begins.The story starts with Patience Phillips (Halle Berry), a timid woman who can't stand up for herself. She lets people walk all over her, and has wasted her artistic talent working for a cosmetic company as a graphic designer. George Hedare (Lambert Wilson) runs the company with his supermodel wife, Laurel (Sharon Stone). Laurel knows that Patience is capable, but seems mostly indifferent, only using her in own power struggles with her husband. George, an abusive boss in general, finds plenty of opportunity to mock Laurel.The company is about to launch BeauLine, a new anti-aging product that Laurel had secretly been using for years. The advertisement is designed by Patience but George, unsatisfied, demands that she redesigns it. Upset and frustrated, Patience returns home and sees a cat looking up at her. Shaking her head, she goes to sleep, but her loud neighbours keeps her up and she is unable to rest. Next morning, the cat is on her window ledge. When she approaches, she realizes the cat has climbed up to a higher ledge and was potentially stuck. To try and reach the cat, Patience climbs out her window ledge, and a passing detective mistakens her intentions as suicidal. He ends up rushing into her apartment and pulling her back in. Patience would have thanked him but realizes she is late for work, in her hurry to leave she drops her wallet. The detective, Tom Lone (Benjamin Bratt), tracks her down to her workplace and returns it to her, and both agree to a coffee date.Later that night, Patience goes to the production factory to deliver her artwork, and she accidentally hears that the BeauLine has unsafe health problems. Stunned, she backs into several tools, revealling her presence. Two men chase her into a large waste water pipe, where she is trapped, and they flush her into the river, where she drowns. The cat that has been appearing in front of Patience appears by her body and gathers several other cats around her.Patience eventually drags herself unsteadily up and returns home. Her movements are off and uncontrollable, and she ends up breaking the glass through her own window. When her neighbours start their usual loud party again, she yells at them to quiet but they again ignore her. The old Patience would have backed down, but now she strodes down, knocks on their door, and promptly beats up the host and destroys the music equipment in front of many shocked guests. When she wakes up the next morning, she almost dismisses everything as a dream until she sees the broken glass. Unfortunately, her memories of what happened before that are blank, and so she cluelessly returns back to work.At work, George loudly yells at Patience in front of all her coworkers for not handling in her project. She tunes him out, which angers him further, and when she apologizes he only continues. Patience than apologizes for wasting her time in the company, and is fired, but as soon as George leaves her colleagues swarm around her in congratulations. Patience packs up her things and while she and her friends are walking home, two dogs instantly begin barking at her and she instinctively hisses at them. When questioned, she explains her behaviour as allergies. When they pass by a jewelry store, Patience's attention is caught by a beautiful collar-like necklace, but is reminded of her new unemployed status and leaves longingly. Once home, she sees the same cat again, and finally close enough she was able to find the address on the cat's owner.The cat belonged to an older woman named Ophelia, a former professor who lived alone in a house full of cats. She explains that the cat constantly appearing in front of Patience is named Midnight, a rare Egyptian", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}68{"query": "Rose Elliot (Irene Miracle), a poet living alone in New York City, discovers an ancient book called The Three Mothers. It tells of the existence of three evil sisters who rule the world with sorrow, tears, and darkness. The book, written by an architect named Varelli, reveals that the three dwell inside separate homes that had been specially designed and built for them by the architect in Rome, Freiburg, and New York. Rose suspects that she is living in one of the buildings and writes to her brother Mark (Leigh McCloskey), a music student in Rome, urging him to visit her. Using clues provided in Varelli's book as a guide, Rose searches the cellar of her building and discovers a hole in the floor which leads to a water-filled ballroom. After accidentally dropping her keys into the water, she enters the flooded room. Swimming under the surface, she sees a portrait bearing the words \"Mater Tenebrarum\" and is able to reclaim the keys. A putrid corpse suddenly rises from the depths, frightening her. She escapes, although a shadowy figure watches her leave the basement.In Rome, Mark attempts to read Rose's letter during class. He is distracted by the intense gaze of a beautiful student (Ania Pieroni). When the class ends she leaves suddenly; Mark follows, leaving the letter behind. His friend Sara (Eleonora Giorgi) picks up the letter, and eventually reads it. Horrified by the letter's contents, she takes a taxi to a library and locates a copy of The Three Mothers. While looking for an exit, Sara is attacked by a monstrous figure who recognizes the book. She throws the book to the ground and escapes. Later that night, she seeks the company of a neighbor named Carlo (Gabriele Lavia) and both are stabbed to death by a gloved killer. Mark discovers the bodies and two torn fragments from Rose's letter. After the police arrive, he walks out of Sara's apartment and sees a taxi slowly driving by. In it is the music student, staring at him intently once again.Mark telephones Rose but is unable to hear her clearly. He promises to visit just before the connection fails. Cut off, Rose sees two shadowy figures preparing to enter her apartment. She leaves through a back door, but is followed. In a decrepit room, she is grabbed from behind by a clawed assailant and brutally murdered.Upon arriving in New York, Mark meets some of the residents of Rose's building, including a nurse (Veronica Lazar) who is caring for the elderly Professor Arnold (Feodor Chaliapin, Jr.), a wheelchair-bound mute. Mark learns from the sickly Countess Elise (Daria Nicolodi) that Rose has disappeared. Elise explains how Rose had been acting strangely. After the two find blood on the carpet outside Rose's room, Mark follows the stains. He suddenly becomes ill and falls unconscious. Elise sees a black-robed figure dragging Mark away, but the figure suddenly stops and gives chase to Elise. She is attacked by dozens of cats, who bite and claw at her flesh. The hooded figure then stabs her to death. Mark staggers to the house's foyer where the nurse and caretaker (Alida Valli) put him to bed.The next day, Mark asks Kazanian (Sacha Pitoeff), the antique dealer who sold Rose the Three Mothers book, about Rose. However, the man provides no information. That night, Kazanian drowns several cats in a Central Park pond and accidentally falls into the water. Hundreds of rats from a nearby drain crawl all over him, gnawing his flesh. A hot dog vendor hears Kazanian's cries and rushes over. The man kills Kazanian with a knife.Carol, the caretaker, discovers the horribly mutilated corpse of Elise's butler (Leopoldo Mastelloni) in the Countess' apartment. Shocked, she drops a lit candle which starts a fire. Attempting to put out the flames, she becomes entangled in burning draperies and falls from a window to her death.Meanwhile, Mark uses a clue from Rose's letter to discover that beneath each floor is a secret", "pos": "Cynthia Nelson (Mariette Hartley), a teacher at the local orphanage, talks with a pastor while watching the sun set before getting ready for a fundraising costume party. Cynthia mentions the \"Santa Ana winds\" which the pastor states are an evil omen. One the orphans, Tommy, wanders into the nearby cemetery where he faintly hears a voice ordering \"To rise; it is time.\" Vampire women rise from their graves and chase Tommy into the clutches of Count Yorga, who was waiting for them. Yorga, having been in the area while creating his undead harem and hiding them in the cemetery, has purchased a manor next to the orphanage. His intent is to prey on the children and staff there to satisfy his and his vampire-brides' thirst for blood and presumably create an undead-army from the community's women. In his human guise, he goes to the orphanage during their costume party and fund raiser, biting on of the guests, Mitzi, outside the event room before introducing himself to those present to which he meets and becomes smitten with Cynthia. Upon returning to his manor and a throne room of sorts where he's greeted by his Brudah and his female vampire servants, sends his undead brides to her house, using mind-control to get Cynthia's family into one room before having the brides break in and attack them. Cynthia's father and mother are killed after being drained of their blood, while Cynthia's sister, Ellen, is fed upon and transformed into a new vampire bride to serve Yorga. Tommy, who was sleeping over, is untouched having fallen under Yorga's power, and blankly looks on as the carnage unfolds. Cynthia is subdued (though not bitten) and carried by the brides to Yorga's residence where she awakens with no memory of the attack. Yorga tells Cynthia that her family were in a car accident and she was left in his care during their recovery. Yorga tries to charm the young woman into willingly becoming his bride though he is warned by his live-in witch that Cynthia will bring his end if he doesn't kill her or turn her into a vampire soon. The next morning, Jennifer, the Nelsons' mute maid, finds the massacre scene and calls the police. By the time the police arrive though, all of the evidence has been mysteriously cleared away, and Tommy claims that nothing has happened. Later that same morning, Bruddah, Yorga's hulking, facially disfigured servant (like Yorga, also returning from an on-screen death in the first film) drags the corpses of Cynthia's mother and father to a quicksand pit on Yorga's property, disposing of the physical evidence while likewise bring Ellen's body to Yorga to complete her transformation. Despite the confusion, David Baldwin, Cynthia's fiance, is suspicious about the Nelsons' disappearance. Meanwhile, memories of the attack on her family slowly start to resurface in Cynthia's mind as she stays within Yorga's manor. Jennifer, suspicious about Tommy's involvement with the Nelson's disappearance and his visits to Yorga's mansion, loses her patience and slaps Tommy who stares at her in a vengeful manner. Meanwhile, Yorga goes to claim Mitzi, killing her boyfriend near their boat house then biting her, draining her blood and making her a new bride. Hours later, Ellen's fiance Jason is lured to Yorga's mansion by Tommy, on the promise that he would find Ellen. Once at the mansion, Tommy disappears, while Jason is reunited with Ellen. However, in her vampirized state, she is now evil and laughs at him for \"not loving her anymore\", distracting him before her fellow brides attack him from behind. Jason breaks free, only to run into Count Yorga, who chases Jason down a hall and strangles him. Bruddah tosses Jason's body into the throne/coffin room for the brides, including Ellen and newly vampiric Mitzi, to feed upon. That evening, Reverend Thomas phones Jennifer, but it is revealed she lay dead on her bed with a large knife sticking out of her chest. From her window, Tommy can be seen walking", "neg": "The figure of a limp woman with long curly hair is seen drifting underwater, and a voiceover questions the end of a life that never truly existed. This life ended in murder, the victim herself unsure of who her killer was and why she was killed. Her death was only metaphorical, for in her place a new life begins.The story starts with Patience Phillips (Halle Berry), a timid woman who can't stand up for herself. She lets people walk all over her, and has wasted her artistic talent working for a cosmetic company as a graphic designer. George Hedare (Lambert Wilson) runs the company with his supermodel wife, Laurel (Sharon Stone). Laurel knows that Patience is capable, but seems mostly indifferent, only using her in own power struggles with her husband. George, an abusive boss in general, finds plenty of opportunity to mock Laurel.The company is about to launch BeauLine, a new anti-aging product that Laurel had secretly been using for years. The advertisement is designed by Patience but George, unsatisfied, demands that she redesigns it. Upset and frustrated, Patience returns home and sees a cat looking up at her. Shaking her head, she goes to sleep, but her loud neighbours keeps her up and she is unable to rest. Next morning, the cat is on her window ledge. When she approaches, she realizes the cat has climbed up to a higher ledge and was potentially stuck. To try and reach the cat, Patience climbs out her window ledge, and a passing detective mistakens her intentions as suicidal. He ends up rushing into her apartment and pulling her back in. Patience would have thanked him but realizes she is late for work, in her hurry to leave she drops her wallet. The detective, Tom Lone (Benjamin Bratt), tracks her down to her workplace and returns it to her, and both agree to a coffee date.Later that night, Patience goes to the production factory to deliver her artwork, and she accidentally hears that the BeauLine has unsafe health problems. Stunned, she backs into several tools, revealling her presence. Two men chase her into a large waste water pipe, where she is trapped, and they flush her into the river, where she drowns. The cat that has been appearing in front of Patience appears by her body and gathers several other cats around her.Patience eventually drags herself unsteadily up and returns home. Her movements are off and uncontrollable, and she ends up breaking the glass through her own window. When her neighbours start their usual loud party again, she yells at them to quiet but they again ignore her. The old Patience would have backed down, but now she strodes down, knocks on their door, and promptly beats up the host and destroys the music equipment in front of many shocked guests. When she wakes up the next morning, she almost dismisses everything as a dream until she sees the broken glass. Unfortunately, her memories of what happened before that are blank, and so she cluelessly returns back to work.At work, George loudly yells at Patience in front of all her coworkers for not handling in her project. She tunes him out, which angers him further, and when she apologizes he only continues. Patience than apologizes for wasting her time in the company, and is fired, but as soon as George leaves her colleagues swarm around her in congratulations. Patience packs up her things and while she and her friends are walking home, two dogs instantly begin barking at her and she instinctively hisses at them. When questioned, she explains her behaviour as allergies. When they pass by a jewelry store, Patience's attention is caught by a beautiful collar-like necklace, but is reminded of her new unemployed status and leaves longingly. Once home, she sees the same cat again, and finally close enough she was able to find the address on the cat's owner.The cat belonged to an older woman named Ophelia, a former professor who lived alone in a house full of cats. She explains that the cat constantly appearing in front of Patience is named Midnight, a rare Egyptian", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}69{"query": "Interleukin-6 (IL-6) can activate downstream signaling pathways in lung cancer cells, such as the STAT3 pathway, and is reported to be produced by tumor cells with activating EGFR mutations. We examined IL-6/STAT3 in lung cancer tumor tissues and the effects of siltuximab, a neutralizing antibody to human IL-6, in mouse models of lung cancer. IL-6 and STAT3 activation levels were compared with tumor histology and presence of KRAS mutations in snap-frozen, non-small-cell lung cancer tumors. The effects of siltuximab alone or in combination with erlotinib were examined in mouse xenograft models constructed using three cell line xenograft models and one primary explant mouse model. We examined the influence of cancer-associated fibroblasts (CAFs) on tumor growth and siltuximab effects. IL-6 levels were higher in tumors of squamous cell versus adenocarcinoma histology and were not associated with presence of KRAS mutations. Tyrosine phosphorylation status of STAT3 did not correlate with tumor IL-6 levels. Serine phosphorylation of STAT3 was correlated with KRAS mutation status. Both tumor and stromal cells contributed to total IL-6 within tumors. Siltuximab had minimal effect as a single agent in xenografts with tumor cells alone; however, in models coadministered with CAFs, siltuximab had more potent effects on tumor inhibition. We observed no effects of combined erlotinib and siltuximab. IL-6 is elevated in subsets of human NSCLCs, especially with squamous cell histology. Tumors supported by stromal production of IL-6 seem to be the most vulnerable to tumor growth inhibition by siltuximab.", "pos": "Interleukin-6 (IL-6) induces tumor growth, invasion, metastasis, and angiogenesis. Siltuximab (CNTO 328) is a chimeric, murine-human monoclonal antibody that specifically binds human IL-6 with high affinity. C-reactive protein (CRP) can be a pharmacodynamic (PD) marker of IL-6 bioactivity. Reductions in CRP may correlate with clinical activity and IL-6 bioactivity. Starting-dose selection for this study was based on a previous siltuximab study in multiple myeloma patients. Pharmacokinetic (PK)/PD modeling explored the relationship between siltuximab PK and CRP suppression following i.v. siltuximab infusion in a three-part phase I/II study in 68 metastatic renal cell carcinoma patients. Modeling results were then used to simulate and determine which siltuximab dosage regimens would maintain CRP suppression below the lower limit of quantification (4 mg/L). Siltuximab was given at 1, 3, 6, or 12 mg/kg at weeks 1 and 4 and then every 2 weeks for 2 cycles in part 1; at 3 or 6 mg/kg every 3 weeks for 4 cycles in part 2; and at 6 mg/kg every 2 weeks for 6 cycles in part 3. A two-compartment PK model adequately described the serum siltuximab concentration-time data. An inhibitory indirect response PD model examined the relationship between siltuximab concentrations and CRP suppression. PD parameter estimates seemed reliable and physiologically relevant. Simulations showed that 6 mg/kg siltuximab every 2 weeks or 9 mg/kg every 3 weeks would reduce serum CRP to below 4 mg/L. Using a stepwise design, PK/PD modeling was used to select the dose levels in this study. Furthermore, PK/PD modeling results were used to help select doses to be used in future siltuximab clinical development.", "neg": "The objective of this study was to analyze the expression levels of multiple components in the mammalian target of rapamycin (mTOR) signaling pathway in radical nephrectomy specimens from patients with metastatic renal-cell carcinoma (RCC) treated with mTOR inhibitors in order to identify factors predicting susceptibility to these agents. This study retrospectively included a total of 48 consecutive patients undergoing radical nephrectomy, who were diagnosed with metastatic RCC and subsequently treated with an mTOR inhibitor (everolimus or temsirolimus) as either first- or second-line systemic therapy. Expression levels of 5 molecular markers involved in the signaling pathway associated with mTOR, including PTEN, phosphorylated (p)-Akt, p-mTOR, p-p70 ribosomal S6 kinase, and p-4E-binding protein 1 (4E-BP1), were measured by immunohistochemical staining of primary RCC specimens. Of several factors examined, bone metastasis, liver metastasis, and the expression level of p-4E-BP1 were shown to have significant impacts on the response to the mTOR inhibitors. Progression-free survival (PFS) was significantly correlated with the expression levels of PTEN and p-4E-BP1 in addition to the presence of bone metastasis on univariate analysis. Of these significant factors, p-4E-BP1 expression and bone metastasis appeared to be independently associated with PFS on multivariate analysis. These findings suggest that it would be useful to consider the expression levels of potential molecular markers in the mTOR signaling pathway, particularly p-4E-BP1, as well as conventional clinical parameters when selecting patients with metastatic RCC who are likely to benefit from treatment with mTOR inhibitors.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}70{"query": "As of the census of 2000, there were 218,590 people, 79,667 households, and 60,387 families residing in the county. The population density was 496 people per square mile (192/km). There were 83,146 housing units at an average density of 189 per square mile (73/km). The racial makeup of the county was 86.77% Race (United States Census), 9.27% Race (United States Census), 0.23% Race (United States Census), 1.52% Race (United States Census), 0.06% Race (United States Census), 0.69% from Race (United States Census), and 1.47% from two or more races. 1.91% of the population were Race (United States Census) or Race (United States Census) of any race. 22.5% were of German people, 13.1% Irish people, 9.8% Italian people, 9.2% English, 8.1% \"American\" and 6.0% Polish ancestry.", "pos": "As of the census of 2000, there were 445,342 people, 169,162 households, and 114,015 families residing in the county. The population density was 615 people per square mile (238/km). There were 178,913 housing units at an average density of 247 per square mile (95/km). The racial makeup of the county was 82.19% Race (United States Census), 1.15% Race (United States Census) or Race (United States Census), 0.65% Race (United States Census), 6.68% Race (United States Census), 0.30% Race (United States Census), 5.86% from Race (United States Census), and 3.17% from two or more races. 11.17% of the population were Race (United States Census) or Race (United States Census) of any race. 17.2% were of German American, 9.9% English American, 8.2% Irish American, and 6.7% Americans ancestry. 81.7% spoke only English at home, while 9.6% spoke Spanish and 1.2% Vietnamese.", "neg": "As of the census of 2000, there were 120,546 people, 41,668 households, and 32,292 families residing in the county. The population density was 262 people per square mile (101/km). There were 43,903 housing units at an average density of 95 per square mile (37/km). The racial makeup of the county was 68.51% Race (United States Census), 26.06% Race (United States Census) or Race (United States Census), 0.75% Race (United States Census), 1.82% Race (United States Census), 0.06% Race (United States Census), 0.72% from Race (United States Census), and 2.08% from two or more races. 2.26% of the population were Race (United States Census) or Race (United States Census) of any race. 11.6% were of german people, 10.8% irish people, 10.2% english people, 9.3% American and 5.3% italian people ancestry.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}71{"query": "Hans Rottiger (16 April 1896 -- 15 April 1960) was a Panzer General in the German army during World War II and the first Inspector of the Army of the Bundeswehr.", "pos": "Johannes Scherg (16 May 1918 -- 22 December 1997) was a Hauptsturmfuhrer (Captain) in the Waffen SS during World War II who was awarded the Knight's Cross of the Iron Cross, which was awarded to recognize extreme battlefield bravery or successful military leadership by Nazi Germany during World War II. Johannes Scherg was born in Wurzburg on the 16 May 1918.", "neg": "JSC NMZ or Nizhny Novgorod Machine-building Plant (Russian: or All-Union Machine-building Plant New Sormovo Russian: '' '', Joseph Stalin Factory No. 92, Zavod imeni Stalina, or ZiS) was a Soviet artillery factory in the Sormovo district of Gorky.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}72{"query": "In the county, the population was spread out with 23.20% under the age of 18, 7.70% from 18 to 24, 27.00% from 25 to 44, 28.00% from 45 to 64, and 14.10% who were 65 years of age or older. The median age was 40 years. For every 100 females, there were 97.00 males. For every 100 females age 18 and over, there were 96.40 males.", "pos": "The median age in the city was 35.1 years. 24.2% of residents were under the age of 18; 7.9% were between the ages of 18 and 24; 33.8% were from 25 to 44; 24.6% were from 45 to 64; and 9.5% were 65 years of age or older. The gender makeup of the city was 48.6% male and 51.4% females.", "neg": "As of the census of 2000, there were 35,100 people, 12,759 households, and 9,071 families residing in the county. The population density was 59 people per square mile (23/km). There were 15,035 housing units at an average density of 25 per square mile (10/km). The racial makeup of the county was 85.8% Race (United States Census), 3.9% Race (United States Census) or Race (United States Census), 1.8% Race (United States Census), 1.0% Race (United States Census), 0.1% Race (United States Census), 5.0% from Race (United States Census), and 2.4% from two or more races. 8.9% of the population were Race (United States Census) or Race (United States Census) of any race. 14.9% were of German people, 12.6% English people, 11.7% Irish people, 8.8% Italian people and 7.3% United States ancestry according to Census 2000. 93.1% spoke English language and 5.1% Spanish language as their first language.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}73{"query": "Apical membrane antigen 1 (AMA1) is an asexual blood-stage protein expressed in the invasive merozoite form of Plasmodia species, which are the causative agent of malaria. We have complemented the function of Plasmodium falciparum AMA1 (PfAMA1) with a divergent AMA1 transgene from Plasmodium chabaudi (PcAMA1). It was not possible to disrupt the PfAMA1 gene using 'knock-out' plasmids, although we demonstrate that the PfAMA1 gene can be targeted by homologous recombination. These experiments suggest that PfAMA1 is critical, perhaps essential, for blood-stage growth. Importantly, we showed that PcAMA1 expression in P. falciparum provides trans-species complementation to at least 35% of the function of endogenous PfAMA1 in human red cells. Furthermore, expression of this transgene in P. falciparum leads to more efficient invasion of murine erythrocytes. These results indicate an important role for AMA1 in the invasion of red blood cells (RBCs) across divergent Plasmodium species.", "pos": "Malaria is a major human health problem and is responsible for over 2 million deaths per year. It is caused by a number of species of the genus Plasmodium, and Plasmodium falciparum is the causative agent of the most lethal form. Consequently, the development of a vaccine against this parasite is a priority. There are a number of stages of the parasite life cycle that are being targeted for the development of vaccines. Important candidate antigens include proteins on the surface of the asexual merozoite stage, the form that invades the host erythrocyte. The development of methods to manipulate the genome of Plasmodium species has enabled the construction of gain-of-function and loss-of-function mutants and provided new strategies to analyse the role of parasite proteins. This has provided new information on the role of merozoite antigens in erythrocyte invasion and also allows new approaches to address their potential as vaccine candidates.", "neg": "Protein methylation is a common posttranslational modification that mostly occurs on arginine and lysine residues. Arginine methylation has been reported to regulate RNA processing, gene transcription, DNA damage repair, protein translocation, and signal transduction. Lysine methylation is best known to regulate histone function and is involved in epigenetic regulation of gene transcription. To better study protein methylation, we have developed highly specific antibodies against monomethyl arginine; asymmetric dimethyl arginine; and monomethyl, dimethyl, and trimethyl lysine motifs. These antibodies were used to perform immunoaffinity purification of methyl peptides followed by LC-MS/MS analysis to identify and quantify arginine and lysine methylation sites in several model studies. Overall, we identified over 1000 arginine methylation sites in human cell line and mouse tissues, and 160 lysine methylation sites in human cell line HCT116. The number of methylation sites identified in this study exceeds those found in the literature to date. Detailed analysis of arginine-methylated proteins observed in mouse brain compared with those found in mouse embryo shows a tissue-specific distribution of arginine methylation, and extends the types of proteins that are known to be arginine methylated to include many new protein types. Many arginine-methylated proteins that we identified from the brain, including receptors, ion channels, transporters, and vesicle proteins, are involved in synaptic transmission, whereas the most abundant methylated proteins identified from mouse embryo are transcriptional regulators and RNA processing proteins.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}74{"query": "Nearly everyone is shy in some ways. If shyness is making you uncomfortable, it may be time for a few lessons in self-confidence. You can build your confidence by following some suggestions from doctors and psychologists. Make a decision not to hold back in conversations. What you have to say is just as important as what other people say. And don't turn down party invitations just because of your shyness. Prepare for yourself for being with others in groups. Make a list of the good qualities you have. Then make a list of ideas, experiences, and skills you would like to share with other people . I think about what you would like to say in advance. Then say it. If you start feeling self-conscious in a group, take a deep breath and focus your attention on other people, Remember, you are not alone. Other people are concerned about the impression they are making, too. No one ever gets over being shy completely, but most people do learn to live with their shyness. Even entertainers admit that they often feel shy. They work at fighting their shy feelings so that they can face the cameras and the public. Just making the effort to control shyness can have many rewards. But perhaps the best reason to fight shyness is to give other people a chance to know about you.", "pos": "Learn to Communicate with Others Talking to Teachers--Teachers are just people behind the desk, living breathing human beings. And they will probably be friendly to people who talk nicely to them. Teachers also seem to get along better with children who take schoolwork seriously and prepare for class. And, just like any other human being, teachers like to be appreciated. The next time your teacher helps you solve a math problem or figure out a science project, say thank you with a smile. Talking to Parents--Parents can be very supportive if their children ask for help. If you think there's something your parents can do to help you feel more comfortable around people, then ask them. Very often, parents want very much to help, but really don't know what to do. Pick a quiet time of the day and ask to talk. Tell them how you feel. Maybe they had the same trouble when they were kids. Talking to Strangers--This is always a tough one. How do you deal with a neighbor, or the mail carrier? That often seems to cause arguments between kids and parents. The answer to these questions will vary from kid to kid, from parent to parent because all cultures are different. Some folks live in small towns where a hello to everyone is ok. Then there are kids who live in the city who may have been taught not to speak to anyone they don't know. If you're having trouble with this and always feel awkward in these kinds of situations, you might want to talk to your parents or a teacher about it.", "neg": "It's no secret that doing good makes others happy - but did you know it can make you happy as well? According to a study, people participating in meaningful activities were happier and felt that their lives had more purpose than people who only engaged in pleasure-seeking behaviors. Try giving these four things to others to start your journey to a happier and healthier lifestyle. 1. Your Time With a busy life, it can be hard to find any time to give away. However, volunteering your time has great benefits, including making new friends and connections, learning new skills and even advancing your career. According to a paper about the link between health and volunteering, volunteering is connected with lower instances of depression and reduces the risk of dying by 22 percent. 2. Your Attention Most of us think we're good listeners, but according to psychologist Paul Donoghue, most people are aware that others don't listen as well as they could. In addition, they're not fully aware that they themselves aren't listening. When practicing mindfulness meditation , you focus on what you experience in the moment and let your thoughts and emotions pass through without judgment. Did you know that giving someone your undivided attention helps you also? When done well, active listening strengthens your focus-which is a major part of good meditation. 3. Your Compassion The psychological meaning of compassion is the ability to understand another person's emotional state. Compassion differs from empathy in that those who experience compassion not only put themselves in another person's shoes, but also want to reduce that person's suffering. A brain-imaging study showed that the brain's pleasure centers are equally active when we give money to the poor as when we receive money ourselves. 4. Your Money According to an experiment, those who spend money on other people are significantly happier than those who spend the same quantity of money on themselves. Whether or not you can offer other gifts, donating money helps make real change happen. It represents time spent, compassion and careful attention to the needs of others.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}75{"query": "As of the 2010 United States Census, there were 1,951,269 people, 715,365 households, and 467,916 families residing in the county. The population density was . There were 840,343 housing units at an average density of . The racial makeup of the county was 60.9% white, 10.5% black or African American, 8.7% Asian, 0.7% Pacific islander, 0.7% American Indian, 13.5% from other races, and 5.1% from two or more races. Those of Hispanic or Latino origin made up 29.1% of the population. In terms of ancestry, 11.7% were Germans, 9.1% were Irish people, 7.6% were English people, 6.3% were Italians, and 2.7% were Americans.", "pos": "As of the census of 2000, there were 120,546 people, 41,668 households, and 32,292 families residing in the county. The population density was 262 people per square mile (101/km). There were 43,903 housing units at an average density of 95 per square mile (37/km). The racial makeup of the county was 68.51% Race (United States Census), 26.06% Race (United States Census) or Race (United States Census), 0.75% Race (United States Census), 1.82% Race (United States Census), 0.06% Race (United States Census), 0.72% from Race (United States Census), and 2.08% from two or more races. 2.26% of the population were Race (United States Census) or Race (United States Census) of any race. 11.6% were of german people, 10.8% irish people, 10.2% english people, 9.3% American and 5.3% italian people ancestry.", "neg": "As of the census of 2000, there were 218,590 people, 79,667 households, and 60,387 families residing in the county. The population density was 496 people per square mile (192/km). There were 83,146 housing units at an average density of 189 per square mile (73/km). The racial makeup of the county was 86.77% Race (United States Census), 9.27% Race (United States Census), 0.23% Race (United States Census), 1.52% Race (United States Census), 0.06% Race (United States Census), 0.69% from Race (United States Census), and 1.47% from two or more races. 1.91% of the population were Race (United States Census) or Race (United States Census) of any race. 22.5% were of German people, 13.1% Irish people, 9.8% Italian people, 9.2% English, 8.1% \"American\" and 6.0% Polish ancestry.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}76{"query": "According to 2011 census of India, Kumbakonam had a population of 140,156 with a sex-ratio of 1,021 females for every 1,000 males, much above the national average of 929. A total of 12,791 were under the age of six, constituting 6,495 males and 6,296 females.The average literacy of the city was 83.21%, compared to the national average of 72.99%. There were a total of 9,519 workers, comprising 32 cultivators, 83 main agricultural labourers, 1,206 in house hold industries, 7,169 other workers, 1,029 marginal workers, 24 marginal cultivators, 45 marginal agricultural labourers, 212 marginal workers in household industries and 0 other marginal workers.", "pos": "As of the census of 2000, there were 325,957 people, 149,937 households, and 94,460 families residing in the county. The population density was 570 people per square mile (220/km2). There were 182,467 housing units at an average density of 319 per square mile (123/km2). The racial makeup of the county was 92.65% Race (United States Census), 4.18% Race (United States Census) or Race (United States Census), 0.22% Race (United States Census), 0.77% Race (United States Census), 0.03% Race (United States Census), 1.14% from Race (United States Census), and 1.02% from two or more races. 4.34% of the population were Race (United States Census) or Race (United States Census) of any race. 89.7% spoke only English language at home; 4.4% spoke Spanish language, 1.3% German language, and 1.0% French language at home.", "neg": "Lombard Street (San Francisco, USA) Known as \"the world's most-crooked street,\" Lombard Street was first built in 1922 to reduce the hill's natural 27 % grade ,which was too steep for most vehicles. Lombard Street owns the record as the street with the most switchbacks in a single block. With eight steep and sharp turns, Lombard Street looks like a giant dizzy snake lying on the road. This famous street in San Francisco is known as the most-challenging street of all. Parliament Street (Exeter, England) This street in England is over a hundred years old today, but what makes it as an urban wonder is not its age but its unbelievable narrow size. Usually, a street is where a vehicle can conveniently pass, but that will never happen in the Parliament Street, as the street measures just 25 inches wide which is just enough for a ly medium-built person to pass. King Fahd's Fountain (Jeddah, Saudi Arabia) The fountain was donated to the city by King Fahd. Being the world's tallest fountain, it deserves to be an urban wonder. It was constructed between 1980 and 1983. This fountain shoots water in an incredible 1023-foot (312m) height which is greater than the height of the Eifel Tower. Because of its seemingly unreachable height, the waters of the King Fahd's Fountain can be sighted even if the visitors are miles apart. Damanhur Temple (Northern Alps of Italy) The underground of the modest homes of Italy's northern Alps is where a massive, richly -decorated temple is found. The Damanhur Temple was secretly constructed in the 1970s. Decorated with impressive murals and vividly-color1ed stain glass, the temple was once seized by the Italian government due to illegalities. After some time, it was returned to Oberto Airaudi, the builder and founder of Damanhur.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}77{"query": "The Steelers' ninth game was an AFC duel with the Patriots. The Steelers trailed early as QB Tom Brady made a 19-yard TD pass to TE Rob Gronkowski. This was followed by kicker Shayne Graham getting a 31-yard field goal. The Steelers responded in the second quarter with kicker Jeff Reed nailing a 22-yard field goal. The Steelers struggled further when Brady threw another TD pass to Gronkowski, this one from 9yards out. That was followed by Brady's scramble 3yards to the endzone for a touchdown (With a failed PAT as the kick went wide-right). The Steelers scored first in the 4th quarter when QB Ben Roethlisberger completed a 6-yard TD pass to WR Emmanuel Sanders. The Steelers looked to create another scoring drive, but it came to a halt when Roethlisberger's pass was intercepted by SS James Sanders and returned 32yards for a touchdown (With a failed 2-point conversion). The Steelers tried to cut the lead with a Roethlisberger 15-yard TD pass to WR Mike Wallace, but the Patriots replied with Brady getting a 25-yard TD pass to Gronkowski. Again the Steelers tried to get closer when Roethlisberger completed a 33-yard TD pass to Wallace, but the Patriots put the game away after Graham hit a 36-yard field goal.", "pos": "Hoping to maintain their winning streak, the Steelers flew to LP Field for an AFC Duel with the Titans. The Steelers wasted no time getting the early lead when on the opening kickoff, Mewelde Moore handed the ball off to rookie wide receiver Antonio Brown, who returned it 89yards for a touchdown. Tennessee would cut the lead when Rob Bironas nailed a 21-yard field goal. Throughout the rest of the game, Pittsburgh scored steadily with kicker Jeff Reed, who hit field goals of 36, 34, 25, and 27yards, putting the Steelers up 19-3. The Titans finally scored a touchdown in the fourth quarter with a Kerry Collins 2-yard pass to former Steeler Nate Washington, and successfully converted the 2-point conversion and onside kick necessary to give themselves the chance to tie the game on the final drive. However, Pittsburgh's defense was able to stop Chris Johnson on a reception as the clock ran out, sealing the victory. Starting quarterback Dennis Dixon sprained his left knee during the second quarter and was replaced by Charlie Batch, but the Steelers defense swarmed the Titans, coming up with four sacks and forcing seven turnovers, the most by Tennessee since 2000. The Titans pulled their starting QB, Vince Young, after his third turnover. After replacing Young, Kerry Collins had two turnovers of his own. Pittsburgh also ended Tennessee running back Chris Johnson's 100-yard rushing streak at 12 games. The NFL's rushing champion had a chance to move one game away from the league record of 14 held by Barry Sanders, but he finished with just 16 carries for 34yards. Steelers linebacker James Harrison had three sacks, forced a fumble and recovered another. Safety Troy Polamalu was credited for an interception and an impressive leaping tackle on Kerry Collins during an attempted goal-line stand by the Steelers to win the game and improve to 2-0.", "neg": "The Steelers stayed home for a 3-game home stand and for a Sunday Night duel against the Ravens. The Ravens scored first when Joe Flacco hooked up with Torrey Smith 35-yard TD pass to take a 7-0 lead for the only score of the first quarter. In the 2nd quarter, the Steelers managed to tie the game up when Ben Roethlisberger found Le'Veon Bell on a 5-yard TD pass for a 7-7 game. They eventually took the lead when Roethlisberger found Martavis Bryant on a 19-yard TD pass to make it a 14-7 game. The Ravens came within 4 as Justin Tucker kicked a 46-yard field goal to make it 14-10 game. However, the Steelers would manage to go ahead by 12 before halftime when Roethlisberger found Markus Wheaton on a 47-yard TD pass followed by a successful 2-point conversion for a 22-10 lead at halftime. After a scoreless 3rd quarter, the Steelers came out strong and went back to work in the 4th when Roethlisberger found Antonio Brown on a 54-yard TD pass making the score 29-10. The Ravens responded with a big play as Jacoby Jones ran a 108-yard kickoff return for a TD to make it a 29-17 game. Roethlisberger found Bryant again on an 18-yard TD pass to make the score 36-17. This was followed by the Ravens trying their hand at coming back when Flacco found Crockett Gillmore on a 1-yard TD pass (with a failed 2-point conversion) for a 36-23 score. But the Steelers were able to seal the game when Roethlisberger found Matt Spaeth on a 33-yard TD pass for a final score of 43-23. A week after passing for a franchise-record six touchdowns against Indianapolis, Roethlisberger duplicated the feat to lead Pittsburgh to its third consecutive win. The 12 touchdown passes over the last two games broke the NFL record of 11 set by Tom Flores for Oakland in the AFL in 1963 and matched by New England's Tom Brady in 2007.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}78{"query": "The rebellion of the city of Danzig was a revolt from December 1575 to December 1577 of the city against the outcome of the Polish-Lithuanian royal election, 1576. The Polish throne was contested by Stephen Bathory and the Holy Roman Emperor Maximillian II. It began on 12 December 1575 when Emperor Maximillian was chosen as monarch by the Polish Senate, while the majority of the szlachta had voted for Bathory. It ended on 16 December 1577. Maximilian's II death in fall of 1576 weakened Danzig's position and made the conflict less about the recognition of the ruler than about Danzig's privileges. With neither side being able to defeat the other militarily, a compromise was reached, with economic as well as religious privileges of the city being restored and recognized, in return for a large reparation and recognition of Bathory as the king.", "pos": "The Peasant revolt in Flanders 1323-1328 was a popular revolt in late medieval Europe. Beginning as a series of scattered rural riots in late 1323, peasant insurrection escalated into a full-scale rebellion that dominated public affairs in Flanders for nearly five years until 1328. The uprising in Flanders was caused by both excessive taxations levied by the Count of Flanders Louis I, and by his pro-French policies. The insurrection had urban leaders and rural factions which took over most of Flanders by 1325. The revolt was led by Nicolaas Zannekin, a rich farmer from Lampernisse. Zannekin and his men captured the towns of Nieuwpoort, Veurne, Ypres and Kortrijk. In Kortrijk, Zannekin was able to capture the count himself. In 1325, attempts to capture Gent and Oudenaarde failed. The King of France, Charles IV intervened, whereupon Louis was released from captivity in February 1326 and the Peace of Arques was sealed. The peace soon failed, and the count fled to France when more hostilities erupted. Louis convinced his new liege Philip VI of France to come to his aid, and Zannekin and his adherents were decisively defeated by the French royal army in the Battle of Cassel.", "neg": "In late July, Danzig was re-inforced by a Dutch garrison, and a combined Danish and Dutch fleet broke the naval blockage imposed on Danzig by Charles X Gustav. On 28-30 July, a combined Brandenburgian-Swedish army was able to defeat the Polish-Lithuanian army in the Battle of Warsaw, forcing John II Casimir to retreat to Lublin. In August, Alexis' army took Livonian Kokenhausen , laid siege to Riga and Dorpat and raided Estonia, Ingria and Kexholm. On 4 October, John II Casimir stormed eczyca in Greater Poland before heading for Royal Prussia, and on 8 October, Wincenty Korwin Gosiewski with 12,000 to 13,000 Lithuanian and Crimean Tartar cavalry overran a Brandenburgian-Swedish force in the Battle of Prostken in Ducal Prussia. Gosiewski then ravaged Ducal Prussia, burning 13 towns and 250 villages, in a campaign that entered folklore because of the high death toll and the high number of captives deported to the Crimea. On 22 October, Gosiewski was defeated by Swedish forces in the Battle of Filipow and turned to Lithuania. Also on 22 October, besieged Dorpat surrendered to Alexis, while the Russian siege of Swedish-held Riga was lifted. John II Casimir meanwhile took Bromberg and Konitz in Royal Prussia, and from 15 November 1656 until February 1657 stayed in Danzig, where a Swedish siege had to be lifted due to Dutch intervention, just 55 kilometers away from Charles X Gustav's quarters in Elbing.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}79{"query": "The European BioSafety Association (EBSA) is a non-profit organization, founded in June 1996, which provides a forum to its members to discuss and debate issues of concern and to represent those working in the field of biosafety and associated activities.", "pos": "The People's Unity Assembly (Catalan: Assemblea d'Unitat Popular, AUP) was an independentist organization and movement active between 1993 and 1996.", "neg": "Brouwerij Nacional Balashi was founded in 1996 by one of Aruba's largest companies, MetaCorp.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}80{"query": "Sir Wilfred Robarts, a famed barrister, has just been released from the hospital in which he stayed for two months following a heart attack. Returning to his practise of law, he takes the case of Leonard Vole, an unemployed man who is accused of murdering his elderly friend, Mrs. Emily French. Vole claims he's innocent, although all evidence points to him as the killer, but his alibi witness, his cold German wife Christine, instead of entering the court as a witness for the defense, becomes the witness for the prosecution and defiantly testifies that her husband is guilty of the murder. Sir Wilfred believes there's something suspicious going on with the case, particularly with Mrs. Vole.", "pos": "The film tells the story of a psychiatrist, Dr. Cross (Vincent Price), who is treating a young woman, Janet Stewart (Anabel Shaw), who is in a coma-state, brought on when she heard loud arguing, went to her window and saw a man strike his wife with a candlestick and kill her. It also stars Lynn Bari as Dr. Cross's nurse/lover, Elaine Jordan. As Stewart comes out of her shock, she recognizes Dr. Cross as the killer. He then takes her to his sanitarium and at Elaine's urging, gives Janet an overdose of insulin under the pretense of administering insulin shock therapy. He can't bring himself to murder her in cold blood, though, and asks Elaine to get the medicine to save her. Elaine refuses, they argue, and he strangles her. A colleague of Dr. Cross, Dr. Harvey, saves Janet's life and Dr. Cross is taken into custody by a lawyer from the District Attorney's office.", "neg": "Upon receiving a divorce in Reno, Helen Trent (Claire Trevor) plans to return to San Francisco and goes back to the boarding house where she is renting a room from Mrs. Kraft (Esther Howard) but discovers two dead bodies in the kitchen. Sam Wild (Lawrence Tierney) is the murderer and has committed the crime out of a jealous drive - one of the bodies was his girl friend Laury Palmer (Isabel Jewell) and the other a new man she was dating. Helen grabs her bags and heads for the train and coincidentally Sam does too pushed by his close friend Marty Waterman (Elisha Cook, Jr.) who stays in Reno to get details on the murder and agrees to meet Sam later. Coincidentally Sam and Helen meet on the train and are attracted to each other in part because in a casino earlier they had flirted across the Craps table. In San Francisco Helen parts with Sam but he crashes in on her and her fiancee Fred Grover (Phillip Terry) and her half-sister Georgia Staples (Audrey Long) who has inherited a large newspaper company. Sam sees a good thing in Grace and successfully seduces her into marrying him partly for the power her money can bring him but also to sustain the attraction he has for Helen. Mrs. Kraft hires seedy private detective Matthew Arnett (Walter Slezak) to find out who killed her good friend Laury and the shamus arrives on the wedding day of Sam and Georgia. Helen manages to leak some information to Arnett but Sam discovers this as well and gets his buddy Marty to track down Mrs. Kraft to put an end to things. But this plan goes awry when Marty stops to try to get more information from Helen and Sam perceives it as a play for the woman. Sam reacts in a jealous pique and Helen realizes that he must be stopped and calls Arnett to bring the police with the information he has gathered from his investigation. Sam discovers Helen's communication with Arnett and pulls his gun just as the police arrive resulting in a climactic shootout.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}81{"query": "Most of the time, you breathe without thinking about it. Breathing is mostly an involuntary action that is controlled by a part of your brain that also controls your heart beat. If you swim, do yoga, or sing, you know you can control your breathing, however. Taking air into the body through the nose and mouth is called inhalation. Pushing air out of the body through the nose or mouth is called exhalation. The woman pictured below is exhaling before she surfaces from the pool water (Figure 1.1). How do lungs allow air in? Air moves into and out of the lungs by the movement of muscles. The most important muscle in the process of breathing is the diaphragm, a sheet of muscle that spreads across the bottom of the rib cage. The diaphragm and rib muscles contract and relax to move air into and out of the lungs. During inhalation, the diaphragm contracts and moves downward. The rib muscles contract and cause the ribs to move outward. This causes the chest volume to increase. Because the chest volume is larger, the air pressure inside the lungs is lower than the air pressure outside. This difference in air pressures causes air to be sucked into the lungs. When the diaphragm and rib muscles relax, air is pushed out of the lungs. Exhalation is similar to letting the air out of a balloon. How does the inhaled oxygen get into the bloodstream? The exchange of gasses between the lungs and the blood happens in tiny sacs called alveoli. The walls of the alveoli are very thin and allow gases to pass though them. The alveoli are lined with capillaries (Figure 1.2). Oxygen moves from the alveoli to the blood in the capillaries that surround the alveoli. At the same time, carbon dioxide moves in the opposite direction, from capillary blood to the alveoli. The gases move by simple diffusion, passing from an area of high concentration to an area of low concentration. For example, initially there is more oxygen in the alveoli than in the blood, so oxygen moves by diffusion from the alveoli into the blood. The process of getting oxygen into the body and releasing carbon dioxide is called respiration. Sometimes breathing is called respiration, but there is much more to respiration than just breathing. Breathing is only the movement of oxygen into the body and carbon dioxide out of the body. The process of respiration also includes the exchange of oxygen and carbon dioxide between the blood and the cells of the body.", "pos": "Your respiratory system is made up of the tissues and organs that allow oxygen to enter your body and carbon dioxide to leave your body. Organs in your respiratory system include your: Nose. Mouth. Larynx. Pharynx. Lungs. Diaphragm. The organs of the respiratory system move air into and out of the body. These structures are shown below (Figure 1.1). What do you think is the purpose of each of these organs? The nose and the nasal cavity filter, warm, and moisten the air you breathe. The nose hairs and the mucus produced by the cells in the nose catch particles in the air and keep them from entering the lungs. Behind the nasal cavity, air passes through the pharynx, a long tube. Both food and air pass through the pharynx. The larynx, also called the \"voice box,\" is found just below the pharynx. Your voice comes from your larynx. Air from the lungs passes across thin tissues in the larynx and produces sound. The trachea, or windpipe, is a long tube that leads down to the lungs, where it divides into the right and left bronchi. The bronchi branch out into smaller bronchioles in each lung. There is small flap called the epiglottis that covers your trachea when you eat or drink. The muscle controlling the epiglottis is involuntary and prevents food from entering your lungs or wind pipe. The bronchioles lead to the alveoli. Alveoli are the little sacs at the end of the bronchioles (Figure 1.2). They look like little bunches of grapes. Oxygen is exchanged for carbon dioxide in the alveoli. That means oxygen enters the blood, and carbon dioxide moves out of the blood. The gases are exchanged between the blood and alveoli by simple diffusion. The diaphragm is a sheet of muscle that spreads across the bottom of the rib cage. When the diaphragm contracts, the chest volume gets larger, and the lungs take in air. When the diaphragm relaxes, the chest volume gets smaller, and air is pushed out of the lungs. \"Grape-like\" alveoli in the lungs.", "neg": "Swimming in the water of Hawaii's Big Island is a fun experience. But it can be more exciting if there are dolphins swimming around and jumping out of the sea too. For many people, it would be a wonderful dream to swim with these lovely animals! However, this may not be good for dolphins. They may get hurt because of human interaction . Dolphins are active and usually look for food at night. In the day, they like to rest in shallow bays . Many people think the dolphins are awake during the day as they swim. But when they sleep they rest half of their brain and keep the other half awake to breathe, so they may be sleeping even when they're swimming in the water. From 2010 to 2013, spinner dolphins of Hawaii's Big Island were exposed to human activities more than 82 percent of the time, according to Julian Tyne, a researcher at Australia's Murdoch University. The National Oceanic and Atmospheric Administration (NOAA) says disturbing the animals in their near-shore habitat could force them to swim to less favorable places, putting them at risk of attack by sharks and other animals. Besides, when people are around, dolphins become more active. Thus, they can't get enough sleep. \"Disturbing their resting behaviors can actually affect their long term health and the health of the dolphin population,\" Ann Garrett of NOAA's National Marine Fisheries Service told the Associated Press. As a result, the NOAA wants to make rules to help protect the dolphins. For example, the agency may ban swimming with the Hawaii spinner dolphins. Or they may stop people from swimming in shallow bays when the dolphins are resting. Tour operators must also be taught to watch for signs to know when the dolphins are in their resting state.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}82{"query": "Police officers Brian Taylor (Jake Gyllenhall) and Mike Zavala (Michael Pena) are close friends and partners in the Los Angeles Police Department. Taylor is filming their police activities for a film project, attaching small cameras to his and Zavala's uniforms and carrying around a camcorder, much to the dismay of their peers and superiors. After shooting two suspects following a high speed chase, the shooting is declared justified by the D.A. and the officers are commended for their actions. Taylor and Zavala's antics are met with scorn by fellow officer Van Hauser (David Harbour).The officers respond to a call regarding a man, Mr. Tre (Cle Shaheed Sloan) scaring off a mailman while intoxicated. Upon arrival, Tre hurls racist insults at the Hispanic Zavala, who responds by accepting a fight, to Taylor's approval. Zavala beats him soundly and arrests him, but wins the man's respect for both fighting fair and not mentioning the fight in the report (which may have sent Tre to prison for life due to Three Strikes). Later that night, Tre and his friends are shot at by a group of Latino gang members and one of his friends is killed. The officers find the now-burnt vehicle used in the drive-by the next day, but are shooed off the scene by homicide detectives as well as Van Hauser, who warns them they will get screwed over by the LAPD someday.Responding to a missing persons report, the officers discover two children bound and locked away in a closet and arrest the distressed mother and her drug-addict husband.The cops arrive as a group at a loud outdoor party, the Hispanics from the drive by shooting are celebrating. The cops and partiers verbally joust and Brian sizes up the gang leader, Big Evil (Maurice Compte). The cops depart telling them to keep the noise down.Taylor begins dating Janet (Anna Kendrick) and feels Janet is the only girl he's dated who can connect with him on an intellectual level. Zavala, who is married and expecting a child, offers him relationship advice.Investigating the South Central area, Taylor has a hunch and determines to scope out the home of the mother of a known gang member and sees an expensive pick up truck in the driveway. A woman walks out of the house and delivers a large soup saucepan with lid to the man in the truck. As the truck drives away, the officers follow and then pull over the man in the truck, ostensibly for having CD hanging off the mirror and illegally obstructing the front view, which is minor traffic violation in California per VC 26708 . As Zavala approaches the driver's window to make contact, the driver suddenly draws a gun and fires, and Zavala deflects the man's arm just in time to avoid being shot. After arresting the driver, the officers find an ornately-decorated, compact .45 Colt automatic pistol, a gold-plated AK-47 rifle, and a large amount of money in his truck (hidden in the soup pot). As revealed later, the money and firearms are connected to a Mexican drug cartel operation in the South Central area as well as the gang that did the drive-by on Tre and others.Days later, the two officers are first responders at a house fire that has trapped children on the second floor. Zavala and Taylor enter the house and rescue two young children and are nearly overcome by heat and smoke. When the mother informs them that a third child remains inside, Zavala to rushes to the aid of the remaining child as Taylor reluctantly follows, barely making it out alive. The two are commended and receive the Medal of Valor for their actions, but Taylor has mixed emotions about the situation. Using the house fire incident as leverage, Taylor convinces Zavala to further investigate the South Central incident, to Zavala's chagrin. Arriving at the house, Taylor and Zavala notice suspicious behavior from outside and enter. They arrest another man, who is also in possession of several ornate firearms: a .45 Colt automatic similar to the first one found at the traffic stop, and a Walther PPK. Investigating further, Taylor discovers a hidden stash of Mexican and Asian", "pos": "The Men in Black are a secret law-enforcement agency that is responsible for policing the extraterrestrial life hidden on Earth, as well as protecting the world from any aliens who attempt to destroy/invade the planet.The film begins on LunarMax, a MiB prison situated on the moon. A one-armed criminal, a Boglodite named Boris the Animal, stages a jailbreak (along the way killing Obadiah Price, a fellow inmate he'd made a deal with). His intention is to rewrite history, with Agent K, the one who arrested and imprisoned him, being a major factor in his plan...On Earth, Agent K and his partner Agent J cover up an arrival of an alien spacecraft, and hear of the prison break. At a Chinese restaurant thats a local haunt for aliens, Agent K discovers Boris (who had previously gone to see Obadiah's son Jeffrey) and the two fight, with J joining in. K is upset that the alien he should have killed is out loose again; he deems it his own affair and forbids J to help him, suspending him. A puzzled J checks up on Boris: he appeared in 1969 to stop the prevention of the ArcNet Shield, a device that K deployed to protect the world from harm (but which killed off the Boglodites, as they can only survive by feeding off worlds). He managed to kill on 15 July 1969 an alien named Roman the Fabulous and on the following day... at this point O cuts him off and tells him not to investigate any further. That night, as K waits for Boris with a gun in his hand, he suddenly vanishes...The next morning, J discovers that he has a new partner, the liberated Agent AA, and that K has been dead for forty years (having been killed by Boris the Animal on 16th July 1969). O notices he is suffering from headaches and craves chocolate milk, which she explains are symptoms of time-fracture (aka the crime of interfering with history, which Obadiah Price was imprisoned for). At this point a Boglodite armada appears; J learns that there was nothing to hold them at bay, with no K to deploy the ArcNet. He theorizes that Boris went back in time to 1969 to kill K, thus changing history to what it was, and proposes to follow him; he heads to Jeffrey Price, who had provided Boris a time-jump device, and gets another one from him, and activates it by jumping off the Chrysler Building just as the Boglodites begin their assault...J arrives in 15 July 1969, with the intention to catch Boris as he is about to murder Roman the Fabulous. However, he is delayed from navigating the era of 1969 (most notably by an altercation with two racist cops), and gets there too late to stop Romans murder by 1969 Boris. He encounters 1969 Agent K, who subdues him and brings him to MiB headquarters. J tells K nothing, but when threatened with getting his memory erased he tells K part of the truth: he came from the future in pursuit of another time-traveler whos trying to change history.K and J follow a trail of clues to Andy Warhols Factory complex, where Warhol is revealed to be MiB Agent W. He notifies them of Griffin, an Arcanian being who has the ability to foresee all timelines and futures; Griffins planet was destroyed by the Boglodites, so he came to live on Earth and brought with him a device which will prevent the Boglodites from consuming the Earth. 1969 Boris arrives at the Factory in search of Griffin, who makes a quick exit with Boris in fast pursuit (to Js displeasure, although K doesnt seem to get too worried).J and K eventually track down Griffin at Shea Stadium, where he is foreseeing the future victory for the Mets baseball team. 1969 Boris appears and captures Griffin, but J and K are able to rescue Griffin, although Boris gets away. Griffin gives them the ArcNet and explains it can only work in zero gravity: K gets the idea to head to Cape Canaveral on 16th July 1969 (the day the Apollo 11 ship launched)", "neg": "The film opens as Los Angeles Police Department Officer Dave Brown (Harrelson) patrols the Rampart Division. Brown is a 24-year veteran of the force, who previously served in the Vietnam War. While training a new officer, he roughs up a suspect to find the location of a meth lab. After work, he goes home to his two daughters and two ex-wives, who are also sisters (Heche and Nixon). After dinner, he goes to a piano bar where he picks up a stranger and has a one night stand. The next day, he is t-boned in his patrol car. When he checks on the driver who hit him, the driver flees from his car, hitting Brown with his door as he exits. When Brown catches the driver, he brutally beats him, and the assault is captured by a bystander. The video creates another controversy for the LAPD, which is already besieged by the Rampart scandal. The Assistant District Attorney (Weaver) urges Brown to simply retire. He refuses and outlines his defense. Over the course of the film, it is revealed that Brown studied law and failed the bar exam, but he remains extremely knowledgeable about case law. Back at the piano bar, Brown picks up a lawyer named Linda (Wright), after first determining that she is not surveilling him. Later he meets with ex-cop Hartshorn (Beatty), who suggests that Brown was set up to distract from the Rampart scandal. As the LAPD exerts more pressure on Brown, he retains legal counsel. Soon after, his ex-wives ask him to leave their houses so that they can sell them. Brown meets again with Hartshorn and mentions his need for cash. Hartshorn tips him off to a high stakes card game happening later that night at the Crystal Market. While Brown surveils the card game, it is knocked off by two armed men. Brown pursues the men. He kills one of them and lets the other go. He then stages the scene to make it look like he was shot at. He realizes that a homeless man nicknamed \"General\" (Foster) witnessed the whole thing from his wheelchair. As another investigation into Brown heats up, he goes to a hotel and blackmails the concierge into giving him a room by threatening to arrest the concierge for running a prostitution ring in the hotel. Next, he blackmails a pharmacist into giving him an assortment of drugs. When he meets with Hartshorn to give him a cut of the money from the card game, Brown asks for the source of Hartshorn's tip about the game. He suspects that he was set up again. Hartshorn refuses to name his source. Brown then meets with General in a parking lot to make sure that he will not testify about witnessing the shooting. The next day, an investigator with the District Attorney, Kyle Timkins (Cube) surveils Brown, who confronts him. Brown insists that he is not a racist, merely a misanthrope. Brown grows increasingly paranoid and reliant on drugs as the pressure on him mounts. When he meets with Hartshorn again, he pulls a gun and accuses Hartshorn of setting him up. The elderly man scuffles with Brown a little bit and then has a heart attack. Instead of calling an ambulance, Brown leaves him to die. Back at the hotel, Brown's two daughters drop off some dry cleaning at his room, and he confesses to his younger daughter that everything she has heard about him is true. Brown summons Timkins to a meeting and tapes a confession in front of him. He admits that he has been a dirty cop, and that in 1987, he killed a business acquaintance. He justified the murder because he knew the man was a serial rapist, which is why he got away with the extrajudicial killing. Timkins refuses the confession, insisting that he will arrest Brown for his most recent murder. The film ends with Brown revisiting his family and staring at his elder daughter on the front porch before disappearing into the night.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}83{"query": "This article explains what methicillin-resistant Staphylococcus aureus (MRSA) is, how it is spread and what the real challenges are in healthcare settings in the UK. It explores the different strains of MRSA and points out the main ways to control their spread. It is intended to be a reference source for all nurses.", "pos": "Asymptomatic colonization with methicillin-resistant Staphylococcus aureus (MRSA) has been described as a risk factor for subsequent MRSA infection. MRSA is an important nosocomial pathogen but has currently been reported in patients without typical risk factors for nosocomial acquisition. This study was designed to evaluate the impact of asymptomatic nares MRSA colonization on the development of subsequent MRSA infection. The incidence of MRSA infection was examined in patients with and patients without MRSA or methicillin-susceptible S. aureus (MSSA) colonization at admission to the hospital and in those who developed colonization during hospitalization. Patients admitted to 5 representative hospital units were prospectively evaluated. Nares samples were obtained for culture at admission and during hospitalization. Laboratory culture results were monitored to identify all MRSA infections that occurred during the study period and 1 year thereafter. Of the 758 patients who had cultures of nares samples performed at admission, 3.4% were colonized with MRSA, and 21% were colonized with MSSA. A total of 19% of patients with MRSA colonization at admission and 25% who acquired MRSA colonization during hospitalization developed infection with MRSA, compared with 1.5% and 2.0% of patients colonized with MSSA (P<.01) and uncolonized (P<.01), respectively, at admission. MRSA colonization at admission increased the risk of subsequent MRSA infection, compared with MSSA colonization (relative risk [RR], 13; 95% confidence interval [CI], 2.7-64) or no staphylococcal colonization (RR, 9.5; 95% CI, 3.6-25) at admission. Acquisition of MRSA colonization also increased the risk for subsequent MRSA infection, compared with no acquisition (RR, 12; 95% CI, 4.0-38). MRSA colonization of nares, either present at admission to the hospital or acquired during hospitalization, increases the risk for MRSA infection. Identifying MRSA colonization at admission could target a high-risk population that may benefit from interventions to decrease the risk for subsequent MRSA infection.", "neg": "Transcription factors of the NFAT (nuclear factor of activated T cells) family are expressed in most immune system cells and in a range of other cell types. Signaling through NFAT is implicated in the regulation of transcription for the immune response and other processes, including differentiation and apoptosis. NFAT normally resides in the cytoplasm, and a key aspect of the NFAT activation pathway is the regulation of its nuclear import by the Ca(2+)/calmodulin-dependent phosphatase calcineurin. In a cell line stably expressing green fluorescent protein (GFP)-NFAT, this import can be triggered by elevation of intracellular calcium and visualized in live cells. Here we show that the inducible nuclear import of GFP-NFAT is efficiently blocked at early stages of herpes simplex virus (HSV) infection. This is a specific effect, since we observed abundant nuclear accumulation of a test viral protein and no impediment to general nuclear localization signal-dependent nuclear import and retention in infected cells. We show that virus binding at the cell surface is not itself sufficient to inhibit the signaling that induces NFAT nuclear translocation. Since the block occurs following infection in the presence of phosphonoacetic acid but not cycloheximide, we infer that the entry of the virion and early gene transcription are required but the effect is independent of DNA replication or late virus gene expression. A consequence of the block to GFP-NFAT import is a reduction in NFAT-dependent transcriptional activation from the interleukin-2 promoter in infected cells. This HSV-mediated repression of the NFAT pathway may constitute an immune evasion strategy or subversion of other NFAT-dependent cellular processes to promote viral replication.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}84{"query": "Hoping to rebound from a divisional home loss to the Eagles, the Cowboys flew to Bank of America Stadium for a Week 16 Saturday night duel with the Carolina Panthers. In the first quarter, Dallas shot first with QB Tony Romo completing a 10-yard TD pass to WR Terrell Owens for the only score of the period. In the second quarter, the 'Boys continued their assault as RB Marion Barber got a 5-yard TD run. The Panthers would get on the board with QB Matt Moore completing an 11-yard TD pass to WR Steve Smith. The Cowboys end the half with rookie kicker Nick Folk getting a 42-yard field goal. In the third quarter, Carolina started to try a comeback as kicker John Kasay getting a 37-yard field goal for the only score of the period. In the fourth quarter, Dallas would respond with Folk kicking a 23-yard field goal. The Panthers tried to rally as Kasay nailing a 25-yard field goal, yet the 'Boys were able to hold off every possible attempt. With the win, the Cowboys improved to 13-2 and clinched homefield through NFC Playoffs with Green Bay's loss to Chicago on Sunday. Terrell Owens (5 receptions for 48 yards and 1 touchdown) left the game in the second quarter with a high left ankle sprain.", "pos": "The Cardinals dueled with the Minnesota Vikings for the #3 seed in the NFC playoffs. Things looked bleak for the Cardinals from the beginning. The Vikings began their first quarter attack with an 82-yard punt return for a TD by Bernard Berrian. Two turnovers for the Cardinals, Kurt Warner interception and an Anquan Boldin fumble, would lead to two touchdown passes from Tarvaris Jackson, a 41-yard pass to Berrian and a 19-yard pass to Sidney Rice. The Vikings took a 28-0 lead at halftime after an 11-yard TD pass from Jackson to Chester Taylor. The Cardinals would rally to cut the lead in half with a Jerheme Urban 50-yard TD catch and a field goal blocked by Dominique Rodgers-Cromartie and recovered by Roderick Hood, who returned it 68 yards for a touchdown. The Vikings would pull away at the end of the third quarter when Jackson threw a 59-yard TD pass to Bobby Wade. Kurt Warner was benched on the Cardinals last drive in the fourth quarter via a coaching decision.", "neg": "This game is well known for an infamous penalty that occurred during the overtime period. The Jets were lining up for a game winning 56-yard field goal in overtime to try and give them the win. Nick folk kicked the ball, but the kick went wide right and the Patriots appeared to be taking over with a chance to win. However, Chris Jones of New England was called for a controversial unsportsmanlike conduct penalty after pushing his teammate into the offensive line. This penalty would later be named \"leaping\". The penalty gave the Jets another chance and made the field goal attempt a 51-yard attempt. This time, Folk drilled the kick, and the Jets would go on to stun the Patriots. With the win, the Jets improved to 4-3.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}85{"query": "Comets are small, icy objects that have very elliptical orbits around the Sun. Their orbits carry them from the outer solar system to the inner solar system, close to the Sun. Early in Earths history, comets may have brought water and other substances to Earth during collisions. Comet tails form the outer layers of ice melt and evaporate as the comet flies close to the Sun. The ice from the comet vaporizes and forms a glowing coma, which reflects light from the Sun. Radiation and particles streaming from the Sun push this gas and dust into a long tail that always points away from the Sun (Figure 1.1). Comets appear for only a short time when they are near the Sun, then seem to disappear again as they move back to the outer solar system. Comet Hale-Bopp, also called the Great Comet of 1997, shone brightly for several months in 1997. The comet has two visible tails: a bright, curved dust tail and a fainter, straight tail of ions (charged atoms) pointing directly away from the Sun. The time between one appearance of a comet and the next is called the comets period. Halleys comet, with a period of 75 years, will next be seen in 2061. The first mention of the comet in historical records may go back as much as two millennia. Short-period comets, with periods of about 200 years or less, come from a region beyond the orbit of Neptune called the Kuiper belt (pronounced KI-per). It contains not only comets, but also asteroids and at least two dwarf planets. Comets with periods as long as thousands or even millions of years come from a very distant region of the solar system called the Oort cloud, about 50,000 100,000 AU from the Sun (50,000 - 100,000 times the distance from the Sun to Earth). Click image to the left or use the URL below. URL:", "pos": "Our solar system began about 5 billion years ago. The Sun, planets and other solar system objects all formed at about the same time. The Sun and planets formed from a giant cloud of gas and dust. This was the solar nebula. The cloud contracted and began to spin. As it contracted, its temperature and pressure increased. The cloud spun faster, and formed into a disk. Scientists think the solar system at that time looked like these disk-shaped objects in the Orion Nebula (Figure Temperatures and pressures at the center of the cloud were extreme. It was so hot that nuclear fusion reactions began. In these reactions hydrogen fuses to make helium. Extreme amounts of energy are released. Our Sun became a star! Material in the disk surrounding the Sun collided. Small particles collided and became rocks. Rocks collided and became boulders. Eventually planets formed from the material (Figure 12.2). Dwarf plants, comets, and asteroids formed too (Figure 12.3). Material at a similar distances from the Sun collided together to form each of the planets. Earth grew from material in its part of space. Moons origin was completely different from Earths. Earth formed like the other planets. Different materials in its region of space collided. Eventually the material made a planet. All of the collisions caused Earth to heat up. Rock and metal melted. The molten material separated into layers. Gravity pulled the denser material into the center. The lighter elements rose to the surface (Figure 12.4). Because the material separated, Earths core is made mostly of iron. Earths crust is made mostly of lighter materials. In between the crust and the core is Earths mantle, made of solid rock. This model for how the Moon formed is the best fit of all of the data scientists have about the Moon. In the early solar system there was a lot of space debris. Asteroids flew around, sometimes striking the planets. An asteroid the size of Mars smashed into Earth. The huge amount of energy from the impact melted most of Earth. The asteroid melted too. Material from both Earth and the asteroid was thrown out into orbit. Over time, this material smashed together to form our Moon. The lunar surface is about 4.5 billion years old. This means that the collision happened about 70 million years after Earth formed. An atmosphere is the gases that surround a planet. The early Earth had no atmosphere. Conditions were so hot that gases were not stable. Earths first atmosphere was different from the current one. The gases came from two sources. Volcanoes spewed gases into the air. Comets carried in ices from outer space. These ices warmed and became gases. Nitrogen, carbon dioxide, hydrogen, and water vapor, or water in gas form, were in the first atmosphere (Figure 12.5). Take a look at the list of gases. Whats missing? The early atmosphere had almost no oxygen. Earths atmosphere slowly cooled. Once it was cooler, water vapor could condense. It changed back to its liquid form. Liquid water could fall to Earths surface as rain. Over millions of years water collected to form the oceans. Water began to cycle on Earth as water evaporated from the oceans and returned again as rainfall.", "neg": "118401 LINEAR (provisional designation 1999 RE70) is an asteroid and main-belt comet (176P/LINEAR) that was discovered by the Lincoln Near-Earth Asteroid Research (LINEAR) 1-metre telescopes in Socorro, New Mexico on September 7, 1999.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}86{"query": "What causes clouds to form? And in general, how does matter change from one state to another? As you may have guessed, changes in energy are involved. Changes of state are physical changes in matter. They are reversible changes that do not involve changes in matters chemical makeup or chemical properties. Common changes of state include melting, freezing, sublimation, deposition, condensation, and vaporization. These changes are shown in Figure 4.18. Each is described in detail below. Energy is always involved in changes of state. Matter either loses or absorbs energy when it changes from one state to another. For example, when matter changes from a liquid to a solid, it loses energy. The opposite happens when matter changes from a solid to a liquid. For a solid to change to a liquid, matter must absorb energy from its surroundings. The amount of energy in matter can be measured with a thermometer. Thats because a thermometer measures temperature, and temperature is the average kinetic energy of the particles of matter. You can learn more about energy, temperature, and changes of state at this URL: [Link] Think about how you would make ice cubes in a tray. First you would fill the tray with water from a tap. Then you would place the tray in the freezer compartment of a refrigerator. The freezer is very cold. What happens next? The warmer water in the tray loses heat to the colder air in the freezer. The water cools until its particles no longer have enough energy to slide past each other. Instead, they remain in fixed positions, locked in place by the forces of attraction between them. The liquid water has changed to solid ice. Another example of liquid water changing to solid ice is pictured in Figure 4.19. The process in which a liquid changes to a solid is called freezing. The temperature at which a liquid changes to a solid is its freezing point. The freezing point of water is 0C (32F). Other types of matter may have higher or lower freezing points. For example, the freezing point of iron is 1535C. The freezing point of oxygen is -219C. If you took ice cubes out of a freezer and left them in a warm room, the ice would absorb energy from the warmer air around it. The energy would allow the particles of frozen water to overcome some of the forces of attraction holding them together. They would be able to slip out of the fixed positions they held as ice. In this way, the solid ice would turn to liquid water. The process in which a solid changes to a liquid is called melting. The melting point is the temperature at which a solid changes to a liquid. For a given type of matter, the melting point is the same as the freezing point. What is the melting point of ice? What is the melting point of iron, pictured in Figure 4.20? If you fill a pot with cool tap water and place the pot on a hot stovetop, the water heats up. Heat energy travels from the stovetop to the pot, and the water absorbs the energy from the pot. What happens to the water next? If water gets hot enough, it starts to boil. Bubbles of water vapor form in boiling water. This happens as particles of liquid water gain enough energy to completely overcome the force of attraction between them and change to the gaseous state. The bubbles rise through the water and escape from the pot as steam. The process in which a liquid boils and changes to a gas is called vaporization. The temperature at which a liquid boils is its boiling point. The boiling point of water is 100C (212F). Other types of matter may have higher or lower boiling points. For example, the boiling point of table salt is 1413C. The boiling point of nitrogen is -196C. A liquid can also change to a gas without boiling. This process is called evaporation. It occurs when particles at the exposed surface of a liquid absorb just enough energy to pull away from the liquid and escape into the air. This happens faster at warmer temperatures. Look at the puddle in Figure 4.21.", "pos": "The water droplets of fog form from water vapor in the air. Fog disappears when the water droplets change back to water vapor. These changes are examples of changes of state. A change of state occurs whenever matter changes from one state to another. Common states of matter on Earth are solid, liquid, and gas. Matter may change back and forth between any two of these states. Changes of state are physical changes in matter. They are reversible changes that do not change matters chemical makeup or chemical properties. For example, when fog changes to water vapor, it is still water and can change back to liquid water again. Several processes are involved in common changes of state. They include melting, freezing, sublimation, deposition, condensation, and evaporation. The Figure 1.1 shows how matter changes in each of these processes. Q: Which two processes result in matter changing to the solid state? A: The processes are deposition, in which matter changes from a gas to a solid, and freezing, in which matter changes from a liquid to a solid. Suppose that you leave some squares of chocolate candy in the hot sun. A couple of hours later, you notice that the chocolate has turned into a puddle like the one pictured in the Figure 1.2. Q: What happened to the chocolate? A: The chocolate melted. It changed from a solid to a liquid. In order for solid chocolate to melt and change to a liquid, the particles of chocolate must gain energy. The chocolate pictured in the Figure 1.2 gained energy from sunlight. Energy is the ability to cause changes in matter, and it is always involved in changes of state. When matter changes from one state to another, it either absorbs energyas when chocolate meltsor loses energy. For example, if you were to place the melted chocolate in a refrigerator, it would lose energy to the cold air inside the refrigerator. As a result, the liquid chocolate would change to a solid Q: Why is energy always involved in changes of state? A: The energy of particles of matter determines the matters state. Particles of a gas have more energy than particles of a liquid, and particles of a liquid have more energy than particles of a solid. Therefore, in order for matter to change from a solid to a liquid or from a liquid to a gas, particles of matter must absorb energy. In order for matter to change from a gas to a liquid or from a liquid to a solid, particles of matter must lose energy.", "neg": "Water is simply two atoms of hydrogen and one atom of oxygen bonded together (Figure 1.1). The hydrogen ions are on one side of the oxygen ion, making water a polar molecule. This means that one side, the side with the hydrogen ions, has a slightly positive electrical charge. The other side, the side without the hydrogen ions, has a slightly negative charge. Despite its simplicity, water has remarkable properties. Water expands when it freezes, has high surface tension (because of the polar nature of the molecules, they tend to stick together), and others. Without water, life might not be able to exist on Earth and it certainly would not have the tremendous complexity and diversity that we see. Water is the only substance on Earth that is present in all three states of matter - as a solid, liquid or gas. (And Earth is the only planet where water is abundantly present in all three states.) Because of the ranges in temperature in specific locations around the planet, all three phases may be present in a single location or in a region. The three phases are solid (ice or snow), liquid (water), and gas (water vapor). See ice, water, and clouds (Figure 1.2). (a) Ice floating in the sea. Can you find all three phases of water in this image? (b) Liquid water. (c) Water vapor is invisible, but clouds that form when water vapor condenses are not. Click image to the left or use the URL below. URL:", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}87{"query": "The Battle of Maysalun (Arabic: ), also called the Battle of Maysalun Pass, was a battle fought between the forces of the Arab Kingdom of Syria and French Army of the Levant on 24 July 1920 near the Maysalun Pass, about 12 miles west of Damascus, close to the Lebanese border.", "pos": "The Battle of Munchengratz (German: Schlacht bei Munchengratz) or Battle of Mnichovo Hradiste (Czech: Bitva u Mnichova Hradiste) was fought near Mnichovo Hradiste, modern day Czech Republic, on 28 June 1866 during the Austro-Prussian War.", "neg": "Future News is a 24-hour news channel in Lebanon, covering local and international news.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}88{"query": "Vedat Dalokay died in a traffic accident on March 21, 1991, in which his wife Ayca (age 44) and son Bars (age 17) were also killed.", "pos": "On July 7, 1981, while being driven from the Chicago area to a speaking engagement near Knox, Indiana, Peace Pilgrim was killed in an automobile accident.", "neg": "When the series was revisited for the 10 year anniversary, both Northstar and Aurora are later killed by Weapon X (Wolverine) and Kirika (X-23 in the main Marvel Universe).", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}89{"query": "Sir Arthur Fell (7 August 1850 -- 29 December 1934) was an English solicitor and Conservative Party politician.", "pos": "Edward Percy Smith (5 January 1891 -- 27 May 1968) was a Conservative Party politician in the United Kingdom.", "neg": "Sir William Bowyer-Smijth, 11th Baronet, DL, JP (22 April 1814 -- 20 November 1883) was a British cricketer, baronet and Conservative Party politician.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}90{"query": "The Giants failed to capitalize on their win from the week before and once again were defeated by the Redskins for the season sweep. Washington never trailed in this game and forced Eli Manning into three interceptions. Although the Giants recorded two off of Rex Grossman, they never were able to get into any sort of offensive groove and lost 23-10. Washington led 17-3 at halftime and never looked back. Grossman threw for 185 yards and a touchdown to Santana Moss. Jabar Gaffney led the Redskins with 85 yards receiving while Hakeem Nicks recorded 73 for the Giants. Manning finished with 257 yards.", "pos": "For the first time in franchise history, the Cowboys wore white pants and navy jerseys. The jerseys are usually paired with silver pants. The white pants were the Color Rush pants with a navy/silver/navy stripe down the side, and the navy jersey is the regular alternate navy jersey, usually worn on Thanksgiving. The Cowboys outscored the Giants to win 30-17 and improve to 7-6 and 2-3 without Elliott. Despite the win against the Giants, the eventual Super Bowl champion Philadelphia Eagles clinched the NFC East title with the win against the Rams.", "neg": "Plunkett finished the game with 16 out of 25 pass completions for 172 yards and a touchdown. Theismann threw for more yards than Plunkett (243), but was just 16 out of 35 and was intercepted twice. He was also sacked six times. Branch was the top receiver of the game with six receptions for 94 yards and a touchdown. Guy punted seven times for 299 yards (42.7 average), with 244 net yards (34.8 average) and planted five of his seven punts inside the 20. Martin recorded a sack, a pass deflection, and a fumble recovery. Riggins, who had rushed for over 100 yards in his last six postseason games, was held to 64 yards and a touchdown on 26 carries, with his longest gain being just 8 yards. Brown was their top receiver with three receptions for 93 yards. Tight end Clint Didier caught five passes for 65 yards. Garrett recorded 100 yards on kickoff returns, and one reception for 17 yards. Part of both of Allens touchdown runs were cutbacks, which, according to New York Daily News writer Larry Fox, burned an overpursuing Redskins defense.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}91{"query": "In yeast, the macromolecular complex Set1/COMPASS is capable of methylating H3K4, a posttranslational modification associated with actively transcribed genes. There is only one Set1 in yeast; yet in mammalian cells there are multiple H3K4 methylases, including Set1A/B, forming human COMPASS complexes, and MLL1-4, forming human COMPASS-like complexes. We have shown that Wdr82, which associates with chromatin in a histone H2B ubiquitination-dependent manner, is a specific component of Set1 complexes but not that of MLL1-4 complexes. RNA interference-mediated knockdown of Wdr82 results in a reduction in the H3K4 trimethylation levels, although these cells still possess active MLL complexes. Comprehensive in vitro enzymatic studies with Set1 and MLL complexes demonstrated that the Set1 complex is a more robust H3K4 trimethylase in vitro than the MLL complexes. Given our in vivo and in vitro observations, it appears that the human Set1 complex plays a more widespread role in H3K4 trimethylation than do the MLL complexes in mammalian cells.", "pos": "Trimethylation of histone H3 Lys4 (H3K4) is associated with transcriptional activation. One of the chief effectors of H3K4 methylation is mixed-lineage leukemia 1 (MLL1), a gene that is disrupted by chromosomal translocation in acute leukemia and a master regulator of Hox and other genes. In a recent paper, core components of the human MLL histone methyltransferase (MT) complex were found to form a structural platform, with one component (WDR5) mediating association between the specific histone H3K4 substrate and the MT. This novel regulatory mechanism, which is conserved from yeast to human, is required for both methylation and downstream target gene transcription.", "neg": "The complex expression patterns observed for many genes are often regulated by distal transcription enhancers. Changes in the nucleotide sequences of enhancers may therefore lead to changes in gene expression, representing a central mechanism by which organisms evolve. With the development of the experimental technique of chromatin immunoprecipitation (ChIP), in which discrete regions of the genome bound by specific proteins can be identified, it is now possible to identify transcription factor binding events (putative cis-regulatory elements) in entire genomes. Comparing protein-DNA binding maps allows us, for the first time, to attempt to identify regulatory differences and infer global patterns of change in gene expression across species. Here, we review studies that used genome-wide ChIP to study the evolution of enhancers. The trend is one of high divergence of cis-regulatory elements between species, possibly compensated by extensive creation and loss of regulatory elements and rewiring of their target genes. We speculate on the meaning of the differences observed and discuss that although ChIP experiments identify the biochemical event of protein-DNA interaction, it cannot determine whether the event results in a biological function, and therefore more studies are required to establish the effect of divergence of binding events on species-specific gene expression.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}92{"query": "Humans use six times as much water today as they did 100 years ago. People living in developed countries use a far greater proportion of the worlds water than people in less developed countries. What do people use all of that water for? Besides drinking and washing, people need water for agriculture, industry, household uses, and recreation (Figure Water use can be consumptive or non-consumptive, depending on whether the water is lost to the ecosystem. Non-consumptive water use includes water that can be recycled and reused. For example, the water that goes down the drain and enters the sewer system is purified and then redistributed for reuse. By recycling water, the overall water consumption is reduced. Consumptive water use takes the water out of the ecosystem. Can you name some examples of consumptive water use? Some of the worlds farmers still farm without irrigation by choosing crops that match the amount of rain that falls in their area. But some years are wet and others are dry. For farmers to avoid years in which they produce little or no food, many of the worlds crops are produced using irrigation. Water used for home, industrial, and agricultural purposes in different regions. Globally more than two-thirds of water is for agriculture. Three popular irrigation methods are: Overhead sprinklers. Trench irrigation: canals carry water from a water source to the fields. Flood irrigation: fields are flooded with water. All of these methods waste water. Between 15% and 36% percent of the water never reaches the crops because it evaporates or leaves the fields as runoff. Water that runs off a field often takes valuable soil with it. A much more efficient way to water crops is drip irrigation (Figure 1.2). With drip irrigation, pipes and tubes deliver small amounts of water directly to the soil at the roots of each plant or tree. The water is not sprayed into the air or over the ground, so nearly all of it goes directly into the soil and plant roots. Why do farmers use wasteful irrigation methods when water-efficient methods are available? Many farmers and farming corporations have not switched to more efficient irrigation methods for two reasons: 1. Drip irrigation and other more efficient irrigation methods are more expensive than sprinklers, trenches, and flooding. 2. In the United States and some other countries, the government pays for much of the cost of the water that is used for agriculture. Because farmers do not pay the full cost of their water use, they do not have any financial incentive to use less water. What ideas can you come up with to encourage farmers to use more efficient irrigation systems? Aquaculture is a different type of agriculture. Aquaculture is farming to raise fish, shellfish, algae, or aquatic plants (Figure 1.3). As the supplies of fish from lakes, rivers, and the oceans dwindle, people are getting more fish from aquaculture. Raising fish increases our food resources and is especially valuable where protein sources are limited. Farmed fish are becoming increasingly common in grocery stores all over the world. Workers at a fish farm harvest fish they will sell to stores. Growing fish in a large scale requires that the fish stocks are healthy and protected from predators. The species raised must be hearty, inexpensive to feed, and able to reproduce in captivity. Wastes must be flushed out to keep animals healthy. Raising shellfish at farms can also be successful. For some species, aquaculture is very successful and environmental harm is minimal. But for other species, aqua- culture can cause problems. Natural landscapes, such as mangroves, which are rich ecosystems and also protect coastlines from storm damage, may be lost to fish farms (Figure 1.4). For fish farmers, keeping costs down may be a problem since coastal land may be expensive and labor costs may be high. Large predatory fish at the 4th or 5th trophic level must eat a lot, so feeding large numbers of these fish is expensive and environmentally costly. Farmed fish are genetically different from wild stocks, and if they escape into the wild they may cause problems for native fish. Because the organisms live so close together", "pos": "People depend on natural resources for just about everything that keeps us fed and sheltered, as well as for the things that keep us entertained. Every person in the United States uses about 20,000 kilograms (40,000 pounds) of minerals every year for a wide range of products, such as cell phones, TVs, jewelry, and cars. Table 1.1 shows some common objects, the materials they are made from, and whether they are renewable or non-renewable. Common Object Natural Resources Used Cars 15 different metals, such as iron, lead, and chromium to make the body. Precious metals like gold, silver, and platinum. Gems like diamonds, rubies, emer- alds, turquoise. Jewelry Are These Resources Renewable or Non-Renewable? Non-renewable Non-renewable Common Object Natural Resources Used Electronic Appliances (TVs, com- puters, DVD players, cell phones, etc.) Clothing Many different metals, like copper, mercury, gold. Food Bottled Water Gasoline Household Electricity Paper Houses Soil to grow fibers such as cotton. Sunlight for the plants to grow. Animals for fur and leather. Soil to grow plants. Wildlife and agricultural animals. Water from streams or springs. Petroleum products to make plastic bottles. Petroleum drilled from wells. Coal, natural gas, solar power, wind power, hydroelectric power. Trees; Sunlight Soil. Trees for timber. Rocks and minerals for construc- tion materials, for example, granite, gravel, sand. Are These Resources Renewable or Non-Renewable? Non-renewable Renewable Renewable Non-renewable and Renewable Non-renewable Non-renewable and Renewable Renewable Non-renewable and Renewable Click image to the left or use the URL below. URL: Click image to the left or use the URL below. URL:", "neg": "It's time to be water efficient! As populations increase across Australia and the rest of the world, demand for water will also increase. If we don't reduce each individual's demand for water (both directly and through embodied water) the water situation will become dire. It is obvious that we cannot increase demands for water much more without detrimental effects to the environment, society and the economy. It's all too easy to blame someone else for the water situation -\"if 70% of water is used for agriculture then that's what we should target\" - but it's not that easy. We all depend on the food and resources that agriculture provides, and while there are definitely opportunities to increase water efficiency on the farm, the solution will take more than that. We each share responsibility for the sustainable management of our water resources, which means using less water at home, in the workplace, at school, on holidays, on the farm, ... everyone, everywhere, every time. It's time to become water efficient! This involves reassessing our relationship with water, and learning to use it more sparingly. On the most basic level, it requires a behavioural change, and assigning a value to water that truly reflects its worth. We can also unlock economic benefits of being water efficient. There are many real world examples given in the case studies on this site. Everybody has a responsibility to save water, if future generations are to enjoy a similar standard of living to the one we enjoy now. In fact, many of the impacts associated with water use are likely to have an effect on our own lives! www.savewater.com.au has been designed to help you respond to the challenge to become water efficient. It acts as a central repository for relevant information and further advice, so that you can actually achieve significant savings. It also showcases those companies with products that will assist you in your goal.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}93{"query": "Weathering is the process that changes solid rock into sediments. Sediments were described in the chapter \"Ma- terials of Earths Crust.\" With weathering, rock is disintegrated. It breaks into pieces. Once these sediments are separated from the rocks, erosion is the process that moves the sediments. While plate tectonics forces work to build huge mountains and other landscapes, the forces of weathering gradually wear those rocks and landscapes away. Together with erosion, tall mountains turn into hills and even plains. The Appalachian Mountains along the east coast of North America were once as tall as the Himalayas. No human being can watch for millions of years as mountains are built, nor can anyone watch as those same mountains gradually are worn away. But imagine a new sidewalk or road. The new road is smooth and even. Over hundreds of years, it will completely disappear, but what happens over one year? What changes would you see? (Figure 1.1). What forces of weathering wear down that road, or rocks or mountains over time? A once smooth road surface has cracks and fractures, plus a large pothole. Click image to the left or use the URL below. URL:", "pos": "Weathering changes solid rock into sediments. Sediments are different sizes of rock particles. Boulders are sedi- ments; so is gravel. At the other end, silt and clay are also sediments. Weathering causes rocks at the Earths surface to change form. The new minerals that form are stable at the Earths surface. It takes a long time for a rock or mountain to weather. But a road can do so much more quickly. If you live in a part of the world that has cold winters, you may only have to wait one year to see a new road start to weather (Figure Mechanical weathering breaks rock into smaller pieces. These smaller pieces are just like the bigger rock; they are just smaller! The rock has broken without changing its composition. The smaller pieces have the same minerals in the same proportions. You could use the expression a chip off the old block to describe mechanical weathering! The main agents of mechanical weathering are water, ice, and wind. Rocks can break apart into smaller pieces in many ways. Ice wedging is common where water goes above and below its freezing point (Figure 9.2). This can happen in winter in the mid-latitudes or in colder climates in summer. Ice wedging is common in mountainous regions. This is how ice wedging works. When liquid water changes into solid ice, it increases in volume. You see this when you fill an ice cube tray with water and put it in the freezer. The ice cubes go to a higher level in the tray than the water. You also may have seen this if you put a can of soda into the freezer so that it cools down quickly. If you leave the can in the freezer too long, the liquid expands so much that it bends or pops the can. (For the record, water is very unusual. Most substances get smaller when they change from a liquid to a solid.) Abrasion is another type of mechanical weathering. With abrasion, one rock bumps against another rock. Gravity causes abrasion as a rock tumbles down a slope. Moving water causes abrasion it moves rocks so that they bump against one another (Figure 9.3). Strong winds cause abrasion by blasting sand against rock surfaces. Finally, the ice in glaciers cause abrasion. Pieces of rock embedded in ice at the bottom of a glacier scrape against the rock below. If you have ever collected beach glass or pebbles from a stream, you have witnessed the work of abrasion. Sometimes biological elements cause mechanical weathering. This can happen slowly. A plants roots grow into a crack in rock. As the roots grow larger, they wedge open the crack. Burrowing animals can also cause weathering. By digging for food or creating a hole to live in the animal may break apart rock. Today, human beings do a lot of mechanical weathering whenever we dig or blast into rock. This is common when we build homes, roads, and subways, or quarry stone for construction or other uses. Mechanical weathering increases the rate of chemical weathering. As rock breaks into smaller pieces, the surface area of the pieces increases. With more surfaces exposed, there are more places for chemical weathering to occur. Lets say you wanted to make some hot chocolate on a cold day. It would be hard to get a big chunk of chocolate to dissolve in your milk or hot water. Maybe you could make hot chocolate from some smaller pieces like chocolate chips, but it is much easier to add a powder to your milk. This is because the smaller the pieces are, the more surface area they have. Smaller pieces dissolve more easily. Chemical weathering is different than mechanical weathering. The minerals in the rock change. The rock changes composition and becomes a different type of rock. Most minerals form at high pressure or high temperatures deep within Earth. But at Earths surface, temperatures and pressures are much lower. Minerals that were stable deeper in the crust are not stable at the surface. Thats why chemical weathering happens. Minerals that formed at higher temperature and pressure change into minerals that are stable at the surface. Chemical weathering is important. It", "neg": "Different rock types weather at different rates. Certain types of rock are very resistant to weathering. Igneous rocks, especially intrusive igneous rocks such as granite, weather slowly because it is hard for water to penetrate them. Other types of rock, such as limestone, are easily weathered because they dissolve in weak acids. Rocks that resist weathering remain at the surface and form ridges or hills. Shiprock in New Mexico is the throat of a volcano thats left after the rest of the volcano eroded away. The rock thats left behind is magma that cooled relatively slowly and is harder than the rock that had surrounded it. Different minerals also weather at different rates. Some minerals in a rock might completely dissolve in water, but the more resistant minerals remain. In this case, the rocks surface becomes pitted and rough. When a less resistant mineral dissolves, more resistant mineral grains are released from the rock. A beautiful example of this effect is the \"Stone Forest\" in China, see the video below: The Shiprock formation in northwest New Mexico is the central plug of resistant lava from which the surrounding rock weath- ered and eroded away. Click image to the left or use the URL below. URL: A regions climate strongly influences weathering. Climate is determined by the temperature of a region plus the amount of precipitation it receives. Climate is weather averaged over a long period of time. Chemical weathering increases as: Temperature increases: Chemical reactions proceed more rapidly at higher temperatures. For each 10o C increase in average temperature, the rate of chemical reactions doubles. Precipitation increases: More water allows more chemical reactions. Since water participates in both mechan- ical and chemical weathering, more water strongly increases weathering. So how do different climates influence weathering? A cold, dry climate will produce the lowest rate of weathering. A warm, wet climate will produce the highest rate of weathering. The warmer a climate is, the more types of vegetation it will have and the greater the rate of biological weathering (Figure 1.2). This happens because plants and bacteria grow and multiply faster in warmer temperatures. Some resources are concentrated by weathering processes. In tropical climates, intense chemical weathering carries away all soluble minerals, leaving behind just the least soluble components. The aluminum oxide, bauxite, forms this way and is our main source of aluminum ore.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}94{"query": "The film opens in 19th century Maryland where several Baltimore policemen are chasing after the screams of a woman in an apartment. The police arrive at the apartment in time only to discover a woman (Jasmina Ilic) sprawled on the floor with her throat sliced open and the corpse of her daughter (Teodora Uveric) stuffed in the chimney. Detective Emmett Fields (Luke Evans) is called to assist in the investigation and discovers that the crime resembles a fictional murder in the short story The Murders in the Rue Morgue, which is part of a collection of stories penned by the writer Edgar Allan Poe (John Cusak).Poe has become a social pariah and penniless drunkard whose stories have not been circulated for some time. He has fallen in love with the beautiful young Emily Hamilton (Alice Eve) and desires to marry her but faces opposition from her father Captain Charles Hamilton (Brendan Gleeson), a military man who loathes Poe and goes to the length of threatening physical violence. Poe is brought to see Fields for questioning and is horrified to learn someone is using his stories as the backdrop for a series of murders. Fields then proposes that Poe volunteer his services to help the police catch the killer and Poe agrees to the task.The two men are called to investigate the murder of literary critic Rufus Griswold (John Warnaby), the man who became Poe's rival after a feud that was published in the Baltimore newspapers. Poe realizes the gruesome crime resembles a scene from The Pit and the Pendulum as Fields notices a red demon mask near the corpse. The two then deduce that the scene of the next crime will take place at Captain Hamilton's annual masquerade ball a scene that will resemble the Masked Ball in The Masque of the Red Death.Fields assigns several members of the Baltimore Police to go undercover as guests at the Masked Ball. Sometime before midnight, at the height of the festivities, a man on horseback dressed in a skeleton costume appears. Fields shoots the man only to learn he was an actor hired for the entertainment and receives an anonymous note. Poe then realizes Emily has been kidnapped, meaning the event was all a distraction. It's revealed in the killer's note that he will continue to commit murders and leave clues to Emily's location. The killer then threatens to kill Emily if Poe does not start writing columns for the newspaper that describe the brutal combination of fact and fiction forcing Poe to comply with the request in order to save Emily.The local Medical School's anatomy class discovers a live raven and the corpse of a prostitute in theatrical clothing. Poe and Fields investigate and deduce the scene resembles The Mystery of Marie Roget except for one detail the blood on the corpse's hands was not an element of Poe's story. The two soon learn the woman was an actress (Ana Sofrenovic) in costume as Lady Macbeth and rush to the theatre where the victim worked, demanding to see all the stage hands. All the stage hands are accounted for except for Maurice Rabichaux (Dejan Cubrilov), a sailor on leave after his ship landed in Baltimore. Poe and Fields notice a mysterious figure running along the catwalks and pursue him but the figure escapes. Fields later makes an off-handed comment that the name of the ship Maurice arrived on is the Fortunato which prompts Poe to realize the next murder will resemble The Cask of Amontillado.Poe and Fields search tunnels under the city with several policemen and discover an area with fresh brickwork, an area that might be where Emily is being held. The officers smash through the brick and discover what appears to be a woman with blonde hair in the costume Emily wore the night she was kidnapped. But the body is revealed to be that of the sailor Maurice, who was dressed to resemble Emily after he was killed and buried in the niche. Two clues are found on Maurice: a pocket watch that was stopped at 12:27 and then stuffed into his mouth, and a tattoo on his back that had some flesh carved out of it. Poe and Fields deduce these clues will give the location of Emily, and Poe realizes a church in Baltimore called Holy Cross is where Emily", "pos": "The Bat has struck again, making off with a priceless necklace even after warning the police that he would rob the safe at precisely 1 a.m., after which he intends to go to country in order to give the police a rest. On his way through the village of Oakdale, the Bat notices someone robbing the Oakdale bank. Intrigued, the Bat follows the robber, who leads him to the old Fleming mansion.Inside the Fleming mansion, Cornelia van Gorder [Grayce Hamptom] and her ditzy maid Lizzie Allen [Maude Eburne] are discussing Cornelia's decision to rent the house for the summer. The big old house is a scary place, and Lizzie doesn't like the strange sounds, the strange caretaker [Spencer Charters], and the strange stories he tells about seeing ghosts in the house. Add to the fact that the Bat has taken to the country, and Lizzie is terrified of everything and anything. She's even gone so far as to set a bear trap outside her bedroom window, just in case the Bat decides to pay a vist. When Cornelia's niece Dale [Una Merkel], who works at the Oakdale Bank, returns home with her boyfriend Brook Bailey[William Bakewell] and tries to pass him off as a gardener, Cornelia is immediately suspicious (Cornelia: Any experience with alopecias? Brook: They dry up if you don't water them.), but Cornelia hires him anyway, at least until she can find out why Dale has brought him home.A rock suddenly comes crashing through the window. A note on it reads: Get out of the house now while there is still time. Immediately thereafter, Dr Venrees [Gustav von Seyffertitz] drops by to inform Cornelia that the Oakdale bank has been robbed of a half million dollars and that Fleming, Sr, the owner of the mansion, is returning from Europe so Cornelia will have to vacate the house. Then, a heavy painting moves, and a voice from behind warns them to get out of the house. Becoming concerned, Cornelia phones the police. When Detective Anderson [Chester Morris] shows up, Cornelia explains her suspicion that Fleming, Jr [Hugh Huntley] is trying to frighten her out of the house, possibly because he rented it to her while his father was out of the country. Nowthat his father is returning, she thinks he may be trying to frighten her into leaving.Soon everyone begins acting suspiciously. The doctor unlocks the broken window and \"forgets\" to relock it until Cornelia relocks it herself. Alone in the parlor for a few moments, Venrees unlocks the window again. Brook starts going around the house pounding on the walls. Dale phones Fleming Jr and asks him to come over. When he does, he brings a blueprint of the house so that they can locate a hidden room. Before they can find it, he is murdered, and Dale hides a piece torn from the blueprint under a tray. A storm is approaching, and the lightning knocks out the electricity. Someone phones from the garage, but when Det Anderson goes out to check, there is no one there. Detective Jones [Charles Dow Clark] arrives to help with the investigation. Dr Venrees finds the torn piece from the blueprint showing that the hidden room is behind a fireplace, but Det Anderson forces him to hand it over. When Anderson is poring over the blueprint, Venrees clobbers him with a heavy statue and locks his body in a closet. In the lightning flashes, the silhouette of the Bat can be seen peering into the window.It gets even more intriguing. Brook turns out to be a cashier from the bank and the primary suspect in the theft. Fleming Sr is seen walking on the roof when he's supposed to be out of the country. Dale finds the secret room behind a fireplace and gets locked in, along with the Bat, Mr Fleming Sr, and the money. The Bat shoots Fleming Sr. Dale escapes and leads Inspector Jones, Cornelia, and Dr Venrees to the secret room. Just as the fireplace swings open, Venrees blows out the candle, allowing whomever was in the room to escape. Finally,", "neg": "New Orleans, Louisiana, 1927. An enraged posse of men descend on the isolated Seven Doors Hotel deep in the swamps. They grab an artist called Schweik (Antoine Saint John), who is cloistered there. Accusing him of being a warlock, Schweik is dragged down to the cellar where he is savagely beaten with heavy chains, tortured with quicklime acid, and crucified with his wrists nailed to a cellar wall, despite his dire warnings of evil to be unleashed.New Orleans, 1981. Liza Merril (Catriona MacColl) is a young woman who arrives from New York City to claim the hotel as her inheritance. No sooner has architect friend Marin Avery (Michele Mirabella) begins to show her around the property, strange incidents begin to happen. A painter (Anthony Flees) falls off his rig and is horribly injured, coughing up blood and babbling about, \"the eyes, the eyes.\" Dr. John McCabe (David Warbeck) arrives to take the injured man to the hospital, and offers Liza some sympathy. Next, a plumber, named Joe, attempts to repair a major leak in the flooded cellar. However, he is murdered by a presence that emerged from behind a slim-caked wall. The atmosphere at the hotel is further chilled by the creepy-looking servants, Arthur (Giampaolo Saccarola) and Martha (Veronica Lazar), who apparently come with the hotel. Martha discovers Joe's dead body in the cellar, and another much older cadaver lying in a pool of dirty water nearby. It is apparently that of Schweik, the artist.Driving down the 14-mile causeway to New Orleans, Liza encounters a strange blind woman, standing in the middle of the desolate highway. The blind woman introduces herself as Emily (Sarah Keller), and tells Liza that she has been waiting for her, although her eyes are occluded with cataracts. Liza drives Emily over to her opulently furnished house in New Orleans. Liza is warned by Emily to leave the hotel while she still can. Meanwhile at the hospital morgue, Dr. John McCabe is performing the autopsy on Joe the plumber while his assistant Harris (Al Cliver) wants to install an EMG machine to the corpse of Schweik. John laughs it off and leaves for lunch, while Harris remains behind to install the EMG machine. After Harris leaves for a call, the EMG machine begins pulsing with activity. A little later, Joe's wife Mary-Anne (Laura De Marchi) arrives with her daughter Jill (Maria Pia Marsale) to dress up her husband's corpse for the funeral, when she is killed in a horrific way by scalded with acid. Jill is then menaced by the re-animated cadaver of Schweik.Liza meets with John McCabe in a downtown bar to discuss her misgivings and anxieties. He expresses puzzlement when Lisa complains about he ineptitude of her weird servants. John claims to have never heard of them before despite knowing everyone in the area. Then a phone call from the bar arrives from Harris who informs John that Mary-Anne's body was found in the morgue, while Jill was found huddled in a corner frightened and unable to speak. After Joe and Mary-Anne's funeral, Emily appears again to Liza that evening at the hotel. Emily tells Liza about the warlock Schweik, who stayed in Room 36 of the hotel and about the supernatural underworld that the hotel conceals. The hotel was built over one of the Seven Gates of Hell, and Schweik has been the Guardian. Emily is about to reveal more when her hands wander over to a canvas depicting a desolate vision of lost souls in a terrible and arid landscape. Suddenly afraid, Emily says that the painting was painted by Schweik before he died, and she runs out of the hotel parlor into the night. But Liza notices a disquieting fact about her sudden departure: Emily made no footfalls on the bare wooden boards as she ran, and neither did her seeing-eye dog.The next day, Liza ventures nervously into Room 36, a dingy phantasmal of sheet-covered furniture and shafts of dusty light. She finds an ancient book, whose weirdly flesh-like cover bears the single word", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}95{"query": "Coming off their season-sweeping road win over the Bears, the Lions went home for a Week 9 interconference duel with the Denver Broncos. In the first quarter, Detroit attacked first with kicker Jason Hanson getting a 43-yard field goal for the first score of the game. In the second quarter, the Lions increased their lead with Hanson kicking a 53-yard field goal and QB Jon Kitna completing a 15-yard TD pass to WR Mike Furrey. Detroit ended the half with Hanson kicking a 38-yard field goal. In the third quarter, the Lions continued their domination as DE Dewayne White returned a fumble 3 yards for a touchdown and Kitna completed a 49-yard TD pass to WR Shaun McDonald. In the fourth quarter, Detroit sealed Denver's doom with NT Shaun Rogers returning an interception 66 yards for a touchdown and RB T. J. Duckett scoring on a 3-yard TD run. The Broncos avoided getting shut out as QB Patrick Ramsey completed a 2-yard TD pass to WR Brandon Stokley. With the win, the Lions improved to 6-2 for the first time since 1999.", "pos": "The Rams started their season on the road against the Lions. The Rams drew first blood in the first quarter with a 48-yard field goal from Greg Zuerlein to take a 3-0 lead for the only score of that quarter. The Lions then took a 7-3 lead with Joique Bell's 1-yard run for a touchdown in the 2nd quarter. The Rams responded with a 29-yard field goal from Zuerlein as they came up within a point 7-6 before on the Lions' next possession, Matthew Stafford was picked off by Cortland Finnegan and it was returned 31 yards for a touchdown as the Rams retook the lead 13-7. The Lions then responded with Jason Hanson kicking a 41-yard field goal to shorten the Rams' lead to 13-10 at halftime. After the break, the Lions scored first with Jason Hanson kicking a 45-yard field goal to tie the game 13-13 for the only score of the 3rd quarter. However, the Rams moved back into the lead in the 4th quarter with Brandon Gibson's 23-yard catch from Sam Bradford to make it 20-13. The Lions tied the game back up with Kevin Smith running for a touchdown from 5 yards out to tie the game 20-20. The Rams then retook the lead with Greg Zuerlein kicking a 46-yard field goal to make the score 23-20. On their last possession, the Lions moved down the field and Matthew Stafford found Kevin Smith on a 5-yard touchdown pass to make the final score 27-23 as the Rams began their season 0-1.", "neg": "San Francisco kept Detroit in the game with missed opportunities, then made just enough plays for a rare two-game winning streak and its first road win. RB Frank Gore set a franchise record with 148 yards rushing in the first half and scored on a 61-yard run before leaving with a concussion. San Francisco led 13-3 at halftime after scoring on three of its first four drives, wishing it had a bigger lead after out gaining Detroit 247-102 yards and recovering a fumble without giving up a turnover. The 49ers had chances to go ahead big in the third quarter because Detroit had two turnovers on its first three plays, but they came away with only a field goal and a 13-point lead. Gore then caught a 7-yard pass, wobbled off the field and didn't return. QB Alex Smith's fumble midway through the third quarter set up a score that helped the Lions get back in the game. The 49ers drove down the field to set up K Joe Nedney's fourth field goal, a key score because it made Detroit go for a TD instead of kicking a tying field goal late in the game. S Keith Lewis intercepted QB Jon Kitna's pass at the 49ers' 2 with 2 minutes left and San Francisco now 4-5 picked up the one first down it needed to seal the game, winning consecutive games for the second time since 2003. RB Frank Gore finished with career-high 159 yards rushing and San Francisco's QB Alex Smith was 14 of 20 for 136 yards with a fumble. WR Arnaz Battle caught six passes for 55 yards, and converted a third-and-4 on the final drive to allow the 49ers to run out the clock. The 49ers' defense again came up huge, allowing only 273 total offensive yards and forcing 4 turnovers. LB Brandon Moore was yet again the story, leading the team with 9 tackles, 2 sacks and forcing 2 turnovers. With the win, the 49ers advanced to 4-5.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}96{"query": "Gas station attendant Clint Ramsey, who works at Martin Bormann's Super Service in the desert, finds himself too irresistible to a series of girls, all of whom have the word \"Super\" in their given names. In the beginning, he is married to the hypersexual, demanding, and jealous SuperAngel (Shari Eubank), who constantly harasses him at work. She orders him home at once when she calls Clint and overhears a female customer, SuperLorna (Christy Hartburg), hitting on him at work. Clint finds SuperAngel's constant accusations and arguing a turnoff and, back at home, they fight after he rejects her aggressive advances. A neighbor calls the police as Clint leaves for a local bar, where the bartender is the very scantily clad SuperHaji (Haji). Meanwhile, SuperAngel seduces Harry Sledge (Charles Napier), the cop who responded to the police call. He is impotent and unable to perform. She repeatedly taunts and insults him over this, which finally results in him killing her by stomping her brutally in a bathtub, then throwing a radio in the water which was plugged into the wall socket. Sledge burns down the house, then tries to pin the murder on Clint. Clint claims being in the pub all night, but SuperHaji has her revenge on him (from insulting her breast size earlier) by refusing to confirm his alibi. Clint is then forced to flee. In his rush to escape, Clint hitchhikes a ride from a boy (John LaZar) and his girlfriend SuperCherry (Colleen Brennan). During the drive, SuperCherry comes on to him and puts his hand over her breast, but then pulls it back. She then tries to give him a handjob over his pants, but he continues to resist her advances. The driver takes offense to Clint rejecting his girlfriend, but she says he probably just wants a closer contact. She again attempts and fails to seduce him and he asks the driver to let him get out. The driver follows him out and beats and robs him. Clint is found by an old farmer who takes him to his farm to heal from his injuries and Clint agrees to work for the farmer for a week to repay him. The farmer has a younger Austrian mail-order bride, SuperSoul (Uschi Digard), who is hypersexual. After energetically satisfying her husband, she comes knocking on Clint's door at night. She immediately pushes him into his bed where she proceeds to mount and rape him, until he manages to overpower her. However, she does the same the following day and this time overpowering him after jumping him from behind in the barn. Looking for SuperSoul, the farmer finds them in the barn, then chases Clint away and punches SuperSoul. Fleeing from the farm, Clint meets a motel owner and his deaf daughter, SuperEula (Deborah McGuire), who convinces him to take a ride with her in her dune buggy to have sex in the desert. They are caught by her father and chased out of town. Clint eventually meets up with SuperVixen (also played by Shari Eubank) at Supervixen's Oasis, a roadside diner. SuperVixen is (inexplicably) a friendly and giving reincarnation of SuperAngel, whose ghost now appears nude between scenes to comment on the plot from atop a bedspring balanced on a mesa. Clint and SuperVixen fall in love and are inseparable, although their common nemesis, Harry Sledge, arrives on the scene and plots ending the lives of the now happy couple.", "pos": "The plot is 24 hours in the life of a glamorous fashion photographer named Thomas (David Hemmings), inspired by the life of an actual \"Swinging London\" photographer, David Bailey.In the opening scene, Thomas wakes up after spending the night at a doss house where he has taken pictures for a book of art photos. He is late for a photo shoot with Veruschka von Lehndorff (playing herself) at his studio, which in turn makes him late for a shoot with other models later in the morning. He grows bored and walks off, leaving the models and production staff in the lurch. As he leaves the studio, two teenage girls who are aspiring models, a blond (Jane Birkin) and a dark-haired brunette (Gillian Hills) ask to speak with him, but the photographer drives off to look at an antiques shop.Wandering into Maryon Park, he takes photos of two lovers making out. The woman (Vanessa Redgrave) is furious at being photographed and demands that Thomas hand over the film, but he refuses. When she walks away to rejoin her boyfriend, he is gone and she runs away with Thomas taking photos of her as she runs.Thomas then meets his agent for lunch, and notices a man following him and looking into his car. Back at his studio, the mysterious woman from the park arrives asking for the film, but he refuses. The woman introduces herself as 'Jane' and tries to seduce Thomas by removing her top to entice him to hand over the film and negatives. Thomas agrees without going any further, but he deliberately hands Jane a different roll. She in turn writes down a telephone number to give to him.After Jane leaves, Thomas begins work on developing his photos that he took that day. His many enlargements of the black and white film are grainy but he finds something strange. In the Maryon Park photos, Thomas notices a figure hiding in the bushes near Jane and her boyfriend and upon enlarging them in a series of 'blow-up' shots, sees that it is a man with a gun (the same man he saw following him earlier). In the shots where Jane is running away with her back to the camera, Thomas also notices something on the ground in the distance. The blow-up shots of the blurred figure on the ground that Jane is running to appears to be a body in the grass. Thomas gets the feeling that he just witnessed the before and afterwards of a murder.Thomas is disturbed by a knock on the door, but it is only the two girls again, with whom he has a group-sex romp in his studio and falls asleep. Awakening, he finds they hope he will photograph them but he tells them to leave, saying, \"Tomorrow! Tomorrow!\"As evening falls, Thomas goes back to the park to investigate and finds a dead body (Jane's dead lover), but he has not brought his camera and is scared off by a twig breaking, as if being stepped on by someone unseen watching him. Thomas returns to his studio to find that someone (possibly Jane and her gunman accomplice) has broken into his place and all the negatives and prints from the park are gone except for one large, very grainy blowup showing the body (which proves nothing). He tries to call the phone number Jane gave him, but learns from the operator that the number does not exist.After driving into town, Thomas sees Jane walking alone on a sidewalk and he pulls his car over and follows her on foot into a night club where The Yardbirds, featuring both Jimmy Page and Jeff Beck on guitar, are seen playing. Thomas moves to confront Jane, but she sees him and runs. Thomas loses her on the crowded street.Thomas then goes to a drug-drenched party in a house on the Thames near central London. He finds a strung-out Veruschka, who had told him that she was going to Paris, and when confronted, she says she is in Paris. Thomas then meets his agent Ron (Peter Bowles), whom he wants to bring to the park", "neg": "Webb Garwood (Van Heflin), a disgruntled cop, is called to investigate a voyeur by Susan Gilvray (Evelyn Keyes). Her husband works nights as an overnight radio personality. Webb falls in love with the young and attractive married woman. Obsessed, he woos her despite her initial reluctance and the two begin an adulterous affair. Webb finds out about an insurance policy on the husband's life. He dreams up a scheme in which a phantom \"prowler\" would be a good scapegoat if Susan's husband should happen to die mysteriously. After becoming a prowler himself, Webb \"investigates\" and then commits the murder, making it look like a tragic accident with he and the husband shooting at each other as each suspected the other of being the prowler. Webb's ruse fools a coroner's jury, thanks in part to both Susan and Webb testifying that they didn't know each other prior to her husband's death. Susan initially suspects Webb of foul play, but becomes convinced of his innocence and subsequently marries him. Shortly after the wedding, Susan informs Webb that she has been pregnant for four months. This is problematic because the date of the child's conception would prove the two had lied in their testimony to cover up their previous relationship, and would thus suggest that Webb's killing of Susan's husband had not been an accident. The two run away to a ghost town named Calico to have the baby without anyone back home knowing. Susan goes into premature labor and Webb finds a doctor, Dr. William James (Wheaton Chambers). Susan realizes that Webb intends to kill Dr. James to preserve their secret, so she warns the doctor who then escapes with the newborn. Susan tells Webb that she knows what he had planned to do and that she now realizes that he intentionally murdered her husband. Realizing the doctor will send the police after him, Webb drives away, leaving his wife in Calico alone. On the way out of town, he find the road blocked by his former partner on the police force who was coming to pay a visit. While attempting to get around his friend's car, Webb sees several police cars coming so he heads for the hills on foot. He refuses to stop and a sheriff's deputy shoots him dead.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}97{"query": "After winning in a close game at home, the Steelers traveled to Cincinnati for Game 2 against the Bengals. The Bengals scored first in the first quarter when Randy Bullock kicked a 35-yard field goal to make it 3-0. They would then make it 10-0 when Andy Dalton found A.J. Green on an 8-yard pass. In the second quarter, Dalton and Green connected again on a 15-yard pass to make it 17-0. The Steelers managed to get on the board before halftime when Chris Boswell put a 30-yard field goal through to make the score 17-3. In the third quarter, the Steelers drew closer when Ben Roethlisberger found Le'Veon Bell on a 35-yard touchdown to make it 17-10. The Bengals moved back ahead by double digits when Randy Bullock kicked a 31-yard field goal to make it 20-10. In the fourth quarter, it was all Steelers when Boswell put up a 37-yard field goal to make it 20-13. Roethlisberger then found Antonio Brown on a 6-yard pass to tie the game up at 20-20. Finally, Boswell was able to seal the victory with a 38-yard field goal to make the final score 23-20. With their sixth straight win over the Bengals, the Steelers improved to 10-2. The victory marks the third time that the Steelers have recorded two different 7+ win streaks within consecutive and separate regular seasons (1975-76, 1994-95). The team also won their 8th straight game against a divisional opponent. With the win, the Steelers began 4-0 in their division for the first time since 2008. The 17-point comeback was the Steelers' largest since they came back from down 17 on December 20, 2015 against the Denver Broncos, and their largest on the road since their 21-point comeback on October 5, 1997 against the Baltimore Ravens.", "pos": "Following their victory over the Patriots, the Steelers remained at home the next week for their second match-up of the season against division rivals the Baltimore Ravens. The Ravens scored first with an 18-yard field goal by kicker Billy Cundiff, the only points scored in the first quarter by either team. Steelers kicker Shaun Suisham answered with a 36-yard field goal early in the second quarter, and a 30-yard field goal near the end, but both of these were quickly matched by Baltimore's Cundiff with a 43-yard and 51-yard field goal, respectively, giving Baltimore a 9-6 lead at halftime. The Ravens then increased their lead in the third quarter when Ray Rice scored the first touchdown of the game on a 4-yard run. The Steelers rallied hard in the fourth quarter, with running back Rashard Mendenhall making a 1-yard run to score a touchdown, and then taking the lead for the first time in the game when quarterback Ben Roethlisberger made a successful 25-yard pass to wide receiver Mike Wallace in the endzone for a second touchdown. On their final drive of the game, the Steelers were ready to potentially increase their lead with a 47-yard field goal kick by Shaun Suisham, but a 5-yard delay of game penalty put them out of field goal range and they were instead forced to punt the ball to the Ravens. The Ravens then began a 92-yard drive, culminating in a 26-yard touchdown pass by quarterback Joe Flacco to wide receiver Torrey Smith in the endzone with just 8 seconds remaining, giving them the game.", "neg": "The Steelers stayed home for a 3-game home stand and for a Sunday Night duel against the Ravens. The Ravens scored first when Joe Flacco hooked up with Torrey Smith 35-yard TD pass to take a 7-0 lead for the only score of the first quarter. In the 2nd quarter, the Steelers managed to tie the game up when Ben Roethlisberger found Le'Veon Bell on a 5-yard TD pass for a 7-7 game. They eventually took the lead when Roethlisberger found Martavis Bryant on a 19-yard TD pass to make it a 14-7 game. The Ravens came within 4 as Justin Tucker kicked a 46-yard field goal to make it 14-10 game. However, the Steelers would manage to go ahead by 12 before halftime when Roethlisberger found Markus Wheaton on a 47-yard TD pass followed by a successful 2-point conversion for a 22-10 lead at halftime. After a scoreless 3rd quarter, the Steelers came out strong and went back to work in the 4th when Roethlisberger found Antonio Brown on a 54-yard TD pass making the score 29-10. The Ravens responded with a big play as Jacoby Jones ran a 108-yard kickoff return for a TD to make it a 29-17 game. Roethlisberger found Bryant again on an 18-yard TD pass to make the score 36-17. This was followed by the Ravens trying their hand at coming back when Flacco found Crockett Gillmore on a 1-yard TD pass (with a failed 2-point conversion) for a 36-23 score. But the Steelers were able to seal the game when Roethlisberger found Matt Spaeth on a 33-yard TD pass for a final score of 43-23. A week after passing for a franchise-record six touchdowns against Indianapolis, Roethlisberger duplicated the feat to lead Pittsburgh to its third consecutive win. The 12 touchdown passes over the last two games broke the NFL record of 11 set by Tom Flores for Oakland in the AFL in 1963 and matched by New England's Tom Brady in 2007.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}98{"query": "Mie Kumagai is a Sega video game producer since 1993, and when the previous boss of the Hitmaker development studio Hisao Oguchi was promoted to president of the whole company, Kumagai became the new studio head and the first ever female president within Sega's development structure.", "pos": "Nurith Aviv is Professor at La Femis (Paris), and was, in 1975, the first woman in France to be officially recognized as a Director of Photography by the CNC (Centre National de la cinematographie).", "neg": "Adidas Championship Football is a soccer video game developed by Ocean Software in 1990.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}99{"query": "If the outside environment of a cell is water-based, and the inside of the cell is also mostly water, something has to make sure the cell stays intact in this environment. What would happen if a cell dissolved in water, like sugar does? Obviously, the cell could not survive in such an environment. So something must protect the cell and allow it to survive in its water-based environment. All cells have a barrier around them that separates them from the environment and from other cells. This barrier is called the plasma membrane, or cell membrane. The plasma membrane ( Figure 1.1) is made of a double layer of special lipids, known as phospholipids. The phospholipid is a lipid molecule with a hydrophilic (\"water-loving\") head and two hydrophobic (\"water-hating\") tails. Because of the hydrophilic and hydrophobic nature of the phospholipid, the molecule must be arranged in a specific pattern as only certain parts of the molecule can physically be in contact with water. Remember that there is water outside the cell, and the cytoplasm inside the cell is mostly water as well. So the phospholipids are arranged in a double layer (a bilayer) to keep the cell separate from its environment. Lipids do not mix with water (recall that oil is a lipid), so the phospholipid bilayer of the cell membrane acts as a barrier, keeping water out of the cell, and keeping the cytoplasm inside the cell. The cell membrane allows the cell to stay structurally intact in its water-based environment. The function of the plasma membrane is to control what goes in and out of the cell. Some molecules can go through the cell membrane to enter and leave the cell, but some cannot. The cell is therefore not completely permeable. \"Permeable\" means that anything can cross a barrier. An open door is completely permeable to anything that wants to enter or exit through the door. The plasma membrane is semipermeable, meaning that some things can enter the cell, and some things cannot. The inside of all cells also contain a jelly-like substance called cytosol. Cytosol is composed of water and other molecules, including enzymes, which are proteins that speed up the cells chemical reactions. Everything in the cell sits in the cytosol, like fruit in a jello mold. The term cytoplasm refers to the cytosol and all of the organelles, the specialized compartments of the cell. The cytoplasm does not include the nucleus. As a prokaryotic cell does not have a nucleus, the DNA is in the cytoplasm.", "pos": "The cell membrane is like the bag holding the Jell-O. It encloses the cytoplasm of the cell. It forms a barrier between the cytoplasm and the environment outside the cell. The function of the cell membrane is to protect and support the cell. It also controls what enters or leaves the cell. It allows only certain substances to pass through. It keeps other substances inside or outside the cell. The structure of the cell membrane explains how it can control what enters and leaves the cell. The membrane is composed mainly of two layers of phospholipids. Figure 3.8 shows how the phospholipids are arranged in the cell membrane. Each phospholipid molecule has a head and two tails. The heads are water loving (hydrophilic), and the tails are water fearing (hydrophobic). The water-loving heads are on the outer surfaces of the cell membrane. They point toward the watery cytoplasm within the cell or the watery fluid that surrounds the cell. The water-fearing tails are in the middle of the cell membrane. Hydrophobic molecules like to be near other hydrophobic molecules. They fear being near hydrophilic molecules. The opposite is true of hydrophilic molecules. They like to be near other hydrophilic molecules. They fear being near hydrophobic molecules. These likes and fears explain why some molecules can pass through the cell membrane while others cannot. Hydrophobic molecules can pass through the cell membrane. Thats because they like the hydrophobic interior of the membrane and fear the hydrophilic exterior of the membrane. Hydrophilic molecules cant pass through the cell membrane. Thats because they like the hydrophilic exterior of the membrane and fear the hydrophobic interior of the membrane. You can see how this works in the video at this link: . MEDIA Click image to the left or use the URL below. URL: Cytoplasm is everything inside the cell membrane (except the nucleus if there is one). It includes the watery, gel-like cytosol. It also includes other structures. The water in the cytoplasm makes up about two-thirds of the cells weight. It gives the cell many of its properties. Why does a cell have cytoplasm? Cytoplasm has several important functions. These include: suspending cell organelles. pushing against the cell membrane to help the cell keep its shape. providing a site for many of the biochemical reactions of the cell. Crisscrossing the cytoplasm is a structure called the cytoskeleton. It consists of thread-like filaments and tubules. The cytoskeleton is like a cellular skeleton. It helps the cell keep its shape. It also holds cell organelles in place within the cytoplasm. Figure 3.9 shows several cells. In the figure, the filaments of their cytoskeletons are colored green. The tubules are colored red. The blue dots are the cell nuclei. Eukaryotic cells contain a nucleus and several other types of organelles. These structures carry out many vital cell functions. The nucleus is the largest organelle in a eukaryotic cell. It contains most of the cells DNA. DNA, in turn, contains the genetic code. This code tells the cell which proteins to make and when to make them. You can see a diagram of a cell nucleus in Figure 3.10. Besides DNA, the nucleus contains a structure called a nucleolus. Its function is to form ribosomes. The membrane enclosing the nucleus is called the nuclear envelope. The envelope has tiny holes, or pores, in it. The pores allow substances to move into and out of the nucleus. The mitochondrion (mitochondria, plural) is an organelle that makes energy available to the cell. Its like the power plant of a cell. It uses energy in glucose to make smaller molecules called ATP (adenosine triphosphate). ATP packages energy in smaller amounts that cells can use. Think about buying a bottle of water from a vending machine. The machine takes only quarters, and you have only dollar bills. The dollar bills wont work in the vending machine. Glucose is like a dollar bill. It contains too much energy for cells to use. ATP is like a quarter. It contains just the right amount of energy for use by cells. A ribosome is a small", "neg": "Your bodys first line of defense is like a castles moat and walls. It keeps most pathogens out of your body. The first line of defense includes physical, chemical, and biological barriers. The skin is a very important barrier to pathogens. It is the bodys largest organ and the most important defense against disease. It forms a physical barrier between the body and the outside environment. The outer layer of the skin, called the epidermis, consists of dead cells filled with the protein keratin. These cells form a tough, waterproof covering on the body. It is very difficult for pathogens to get through the epidermis. The inside of the mouth and nose are lined with mucous membranes. Other organs that are exposed to substances from the environment are also lined with mucous membranes. These include the respiratory and digestive organs. Mucous membranes arent tough like skin, but they have other ways of keeping out pathogens. One way mucous membranes protect the body is by producing mucus. Mucus is a sticky, moist secretion that covers mucous membranes. The mucus traps pathogens and particles so they cant enter the body. Many mucous membranes are also covered with cilia. These are tiny, hair-like projections. Cilia move in waves and sweep mucus and trapped pathogens toward body openings. You can see this in the diagram in Figure 21.10. When you clear your throat or blow your nose, you remove mucus and pathogens from your body. In addition to mucus, your body releases a variety of fluids, including tears, saliva, and sweat. These fluids contain enzymes called lysozymes. Lysozymes break down the cell walls of bacteria and kill them. Your stomach contains a very strong acid, called hydrochloric acid. This acid kills most pathogens that enter the stomach in food or water. Urine is also acidic, so few pathogens are able to grow in it. Your skin is covered by millions of bacteria. Millions more live inside your body, mainly in your gastrointestinal tract. Most of these bacteria are helpful. For one thing, they help defend your body from pathogens. They do it by competing with harmful bacteria for food and space. They prevent the harmful bacteria from multiplying and making you sick. Did you ever get a splinter in your skin, like the one in Figure 21.11? It doesnt look like a serious injury, but even a tiny break in the skin may let pathogens enter the body. If bacteria enter through the break, for example, they could cause an infection. These bacteria would then face the bodys second line of defense. If bacteria enter the skin through a splinter or other wound, the area may become red, warm, and painful. These are signs of inflammation. Inflammation is one way the body reacts to infections or injuries. It occurs due to chemicals that are released when tissue is damaged. The chemicals cause nearby blood vessels to dilate, increasing blood flow to the area. The chemicals also attract white blood cells to the area. The white blood cells leak out of the blood vessels and into the damaged tissue. You can see an animation of the inflammatory response by watching this video: MEDIA Click image to the left or use the URL below. URL: The white blood cells that go to a site of inflammation and leak into damaged tissue are called phagocytes. They start eating pathogens and dead cells by engulfing and destroying them. This process is called phagocytosis. You can see how it happens in Figure ??. You can see it in action in the animation at this link: [Link] Phagocytes also release chemicals that cause a fever. A fever is a higher-than-normal body temperature. Normal human body temperature is 98.6 F (37 C). Most bacteria and viruses that infect people reproduce quickly at this temperature. When the temperature rises higher, the pathogens cant reproduce as quickly. Therefore, a fever helps to limit the infection. A fever also causes the immune system to make more white blood cells to fight the infection.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}100{"query": "Love Canal gained worldwide attention in the late 1970s when the press started covering its story. The story is outlined below and illustrated in Figure 19.9. The Love Canal disaster actually began back in the mid 1900s. The disaster continues even today. Starting in the early 1940s, a big chemical company put thousands of barrels of chemical waste into an old canal. Over the next 10 years, the company dumped almost 22,000 tons of chemicals into the ground! In the early 1950s, the company covered over the barrels in the canal with soil. Then they sold the land to the city for just a dollar. The city needed the land in order to build an elementary school. The company warned the city that toxic waste was buried there. But they thought the waste was safe. The school and hundreds of homes were also built over the old canal. As it turned out, the cheap price was no bargain. Chemicals started leaking from the barrels. Chemicals seeped into basements. Chemicals bubbled up to the surface of the ground. In some places, plants wouldnt even grow on the soil. People noticed bad smells. Many got sick, especially the children. Residents wanted to know if the old chemicals were the cause. But they had a hard time getting officials to listen. So they demonstrated and demanded answers. Finally, the soil was tested and was found to be contaminated with harmful chemicals. For example, it contained a lot of lead and mercury. Both can cause permanent damage to the human nervous system. The school was closed. More than 200 homes were evacuated. Much of the Love Canal neighborhood was bulldozed away. The area had a massive clean-up effort. The cleanup cost millions of dollars. More than three decades later, much of Love Canal is still too contaminated to be safe for people. Love Canal opened peoples eyes to toxic waste burial. They realized there must be other Love Canals all over the country. Thousands of contaminated sites were found. The Superfund Act was passed in 1980. The law required that money be set aside for cleanup of toxic waste sites, like the Elizabeth Copper Mine in Vermont (see the far-right image in Figure 19.9). The law also required safer disposal of hazardous waste in the future. Love Canal highlighted the problem of pollution by hazardous waste. Hazardous waste is any waste that is dangerous to the health of people or the environment. It may be dangerous because it is toxic, corrosive, flammable, or explosive. Toxic waste is poisonous. Toxic waste may cause cancer or birth defects in people. It may also harm other living things. Corrosive waste is highly reactive with other substances. Corrosive waste may cause burns or destroy other materials that it touches. Flammable waste can burn easily. It may also give off harmful fumes when it burns. Explosive waste is likely to explode. The risk of explosion may be greater if the waste is mixed with other substances. Table 19.1 shows some examples of hazardous waste. Look closely. Are any of these examples lurking around your home? Example Description Cars contain toxic fluids such as brake fluid. The fluids may also be corrosive and flammable. This photo shows one way the fluids can end up in the ground. Cars use gas and oil. These materials are toxic and flammable. They pollute the land when they leak or spill. Batteries contain toxic and corrosive materials. People often toss them in the trash, but they should be disposed of properly. Electronics, such as old computers, contain toxic chem- icals. They may be sent to landfills where the toxic materials end up in the ground. Medical waste can contain many hazards: Human body fluids may cause disease; old thermometers may contain toxic mercury; and pharmaceuticals may be toxic to people and other living things. Example Description Paints can be both toxic and flammable. Paints may spill on the ground or be thrown improperly in the trash. Chemicals are applied to farm fields and lawns. They include fertilizers, herbicides, and pesticides. Many of these chemicals are toxic to people and other animals. The greatest source of hazardous waste is industry. Agriculture is another major", "pos": "Nations that have more industry produce more hazardous waste. Currently, the United States is the worlds largest producer of hazardous wastes, but China, which produces so many products for the developed world, may soon take over the number-one spot. Countries with more industry produce more hazardous wastes than those with little industry. Problems with haz- ardous wastes and their disposal became obvious sooner in the developed world than in the developing world. As a result, many developed nations, including the United States, have laws to help control hazardous waste disposal and to clean toxic sites. As mentioned in the \"Impacts of Hazardous Waste\" concept, the Superfund Act requires companies to clean up contaminated sites that are designated as Superfund sites (Figure 1.1). If a responsible party cannot be identified, because the company has gone out of business or its culpability cannot be proven, the federal government pays for the cleanup out of a trust fund with money put aside by the petroleum and chemical industries. As a result of the Superfund Act, companies today are more careful about how they deal with hazardous substances. Superfund sites are located all over the nation and many are waiting to be cleaned up. The Resource Conservation and Recovery Act of 1976 requires that companies keep track of any hazardous materials they produce. These materials must be disposed of using government guidelines and records must be kept to show the government that the wastes were disposed of safely. Workers must be protected from the hazardous materials. To some extent, individuals can control the production and disposal of hazardous wastes. We can choose to use materials that are not hazardous, such as using vinegar as a cleanser. At home, people can control the amount of pesticides that they use (or they can use organic methods of pest control). It is also necessary to dispose of hazardous materials properly by not pouring them over the land, down the drain or toilet, or into a sewer or trashcan. Click image to the left or use the URL below. URL:", "neg": "In the mid 1900s, people were startled to see the Cuyahoga River in Cleveland, Ohio, burst into flames! The river was so polluted with oil and other industrial wastes that it was flammable. Nothing could live in it. You can see the Cuyahoga River in Figure 21.16 Disasters such as rivers burning led to new U.S. laws to protect the water. For example, the Environmental Protection Agency (EPA) was established, and the Clean Water Act was passed. Now, water is routinely tested. Pollution is tracked to its source, and polluters are forced to fix the problem and clean up the pollution. They are also fined. These consequences have led industries, agriculture, and communities to pollute the water much less than before. Most water pollution comes from industry, agriculture, and municipal sources. Homes are part of the municipal source and the individuals and families that live in them can pollute the water supply. What can you do to reduce water pollution? Read the tips below. Properly dispose of motor oil and household chemicals. Never pour them down the drain. Also, dont let them spill on the ground. This keeps them out of storm sewers and bodies of water. Use fewer lawn and garden chemicals. Use natural products instead. For example, use compost instead of fertilizer. Or grow plants that can thrive on their own without any extra help. Repair engine oil leaks right away. A steady drip of oil from an engine can quickly add up to gallons. When the oil washes off driveways and streets it can end up in storm drains and pollute the water supply. Dont let pet litter or pet wastes get into the water supply (see Figure 21.17). The nitrogen they contain can cause overgrowth of algae. The wastes may also contain bacteria and other causes of disease. Water treatment is a series of processes that remove unwanted substances from water. The goal of water treatment is to make the water safe to return to the natural environment or to the human water supply. Treating water for other purposes may not include all the same steps. Thats because water used in agriculture or industry may not have to be as clean as drinking water. You can see how water for drinking is treated in Figure 21.18. Treating drinking water requires at least four processes: 1. Chemicals are added to untreated water. They cause solids in the water to clump together. This is called coagulation. 2. The water is moved to tanks. The clumped solids sink to the bottom of the water. This is called sedimentation. 3. The water is passed through filters that remove smaller particles from the water. This is called filtration. 4. Chlorine is added to the water to kill bacteria and other microbes. This is called disinfection. Finally, the water is pure enough to drink. Conserving water means using less of it. Of course, this mostly applies to people in the wealthy nations that have the most water and also waste the most. Irrigation is the single biggest use of water. Overhead irrigation wastes a lot of water. Drip irrigation wastes a lot less. Figure 21.19 shows a drip irrigation system. Water pipes run over the surface of the ground. Tiny holes in the pipes are placed close to each plant. Water slowly drips out of the holes and soaks into the soil around the plants. Very little of the water evaporates or runs off the ground. Some communities save water with rationing. Much rationing takes place only during times of drought. During rationing, water may not be used for certain things. For example, communities may ban lawn watering and car washing. People may be fined if they use water in these ways. You can do your part. Follow any bans where you live. Its easy to save water at home. If you save even a few gallons a day you can make a big difference over the long run. The best place to start saving water is in the bathroom. Toilet flushing is the single biggest use of water in the home. Showers and baths are the next biggest use. Follow the tips below to save water at home. Install", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}101{"query": "In 1982, in New Jersey, Gracie (Mary Ashleigh Green) is in a school playground where one boy is bullying another. She steps in and beats up the bully to help the victim, a boy she likes. But instead of being grateful, he feels humiliated at being rescued \"by a girl,\" and gets angry at her. She promptly punches him in the nose and then sulks alone in the playground. Fast-forward to the present day, and Gracie Hart (Sandra Bullock) is an FBI Special Agent. In the middle of an operation against Russian mobsters, the target starts to choke on some food, and Gracie disobeys her superior's command in order to prevent the target from choking. As a result, a member of her squad gets shot, and she is reprimanded by being reassigned to a desk job. Soon afterwards, the bureau learns that there has been a bomb threat against the 75th annual Miss United States beauty pageant in San Antonio, Texas, which the bureau determines came from the notorious domestic terrorist known as \"The Citizen\". Gracie's partner, Special Agent Eric Matthews (Benjamin Bratt), is chosen to lead the mission to prevent the attack. Despite Eric's position as a lead agent in charge, it is apparent that Gracie is the more capable agent, as Eric is unsure of how to proceed and takes credit for Gracie's suggestions. One of Gracie's suggestions is to put an agent undercover at the pageant. Gracie's male colleagues then proceed to have a bit of fun running the digital images of female and male agents through a website meant for children to play dress up with their dolls. Despite the immature and chauvinistic actions of the agents, Eric recognizes that Gracie is the female FBI agent best qualified for the undercover job. Beauty pageant coach Victor Melling (Michael Caine), whose reputation was ruined after his last contestant criticized his methods, teaches the tomboyish Gracie how to dress, walk, and act like a contestant. She is not used to such behavior, however, and sees the pageant and its participants as \"antifeminist \". Eventually though Victor and Gracie come to respect each other's strengths. Representing New Jersey as \"Gracie Lou Freebush\", Gracie impresses the audience by playing the glass harp and demonstrating self-defense techniques during the talent competition. She also unexpectedly becomes friends with the other contestants, in particular Miss Rhode Island, Cheryl Frasier (Heather Burns) Several suspects emerge, including the corrupt competition director and former pageant winner Kathy Morningside (Candice Bergen); her unpleasant assistant Frank Tobin (Steve Monroe); the veteran pageant MC Stan Fields (William Shatner) who, like Kathy, is being replaced with a younger person; and last but not least Cheryl, who appears to have a history as a radical animal rights activist. While Gracie takes Cheryl and some of the other girls out partying, in an attempt to seek out more information about Cheryl's past through \"girl talk\", The Citizen is arrested elsewhere on an unrelated charge. After hearing what some of the other contestants said about Kathy Morningside's past (she won the pageant only after the original winner \"mysteriously\" contracted food poisoning), Gracie begins to suspect her, and is worried about the safety of the girls. Her boss thinks that her suspicions are groundless and that the pageant is out of danger now that the Citizen has been arrested. He calls off the mission. Gracie opts to turn in her badge and gun and continue the investigation alone. Eric initially fails to support Gracie and is about to return to the bureau when he figures out that Gracie's suspicions must be correct, and returns to help her. In the final round of the pageant, Gracie earns 1st Runner up while Cheryl becomes Miss United States. Gracie realizes that Kathy Morningside and Frank Tobin unknown to anyone (except Victor) is Kathy's son impersonated \"The Citizen\" and made the threat. Because she was going to be fired after the pageant was over, Kathy and her son were planning to murder the newly crowned pageant winner on stage by putting an explosive device in her", "pos": "Anna Foster (Mandy Moore) is the daughter of the President of the United States, James (Mark Harmon) and First Lady Michelle Foster (Caroline Goodall).When a hassle of Secret Service agents ruins a first date, Anna demands some freedom. Her dad agrees to send only two agents with Anna and Gabrielle La Clare (Beatrice Rosen) to a concert when Anna goes to Prague with her parents. A sexy new look for Anna causes her father to renege. When Anna discovers the concert is filled with agents and that her father has broken his promise, Gabrielle helps Anna elude her protectors. Outside the concert, Anna meets Ben Calder (Matthew Goode), and asks him to drive her to escape the agents. Anna goes to a bar with Ben and proceeds to get drunk. Unbeknownst to Anna, Ben is with the Secret Service, and tells agents Alan Weiss (Jeremy Piven) and Cynthia Morales (Annabella Sciorra) where Anna is. The President orders the three agents to have Ben guard Anna without telling her who he really is, to give her an illusion of freedom with a guarantee of safety. Believing herself free of her guards for the first time in years, Anna jumps into the Vltava River naked, mistaking it for the Danube, and Ben has to fish her out (he stays clothed). Weiss and Morales buy the camera from someone taking pictures of the skinny-dipping Anna. Anna and Ben climb a rooftop to watch an opera being shown in a plaza, where Anna eventually falls asleep with Ben guarding her, and Weiss and Morales watching from another roof.The next morning, Anna calls her parents to avoid getting into further trouble with them. Knowing she is safe, her father is initially indulgent, and Anna is about to return, but his tone changes when he is shown the photos of her nude in the river. The First Lady, however, asks, \"What happened to 'let freedom ring?'\" (That had been his earlier line when he had decided to let her stay out with Ben.) Anna is outraged at both her dad's sudden imperious tone and finding out that he traced her call. She decides to meet Gabrielle at the Love Parade in Berlin and return to her parents right before the plane trip home. Ben goes with her on the train, where they meet Scotty McGruff (Martin Hancock), a flighty romantic obsessed with Six Million Dollar Man stickers and the interconnectivity of the world, he gives them a stack of stickers and tells them to stick them up in random places, then one day when they are unhappy, they will see one and it will make them smile. Through him, the two learn that they have boarded a Venice-bound train. When they arrive in Venice, Ben calls the other agents to tell them where they are but has to leave the phone dangling when he realizes he can no longer see Anna. He finds her and McGruff getting new clothes, and the three explore Venice - until McGruff steals their wallets. Ben is about to tell the cafe they cannot pay when Anna is recognized and races off to avoid being identified as the First Daughter. Ben follows, and they tell a story of marrying, against the wishes of Anna's parents, to get a gondola ride from a kind-hearted gondolier, Eugenio (Joseph Long). Ben kisses Anna during the ride to hide her from the cafe staff's sight. Since they have no place to stay, Eugenio invites them to his and his mother Maria's (Miriam Margolyes) house. That night, thinking the kiss meant that Ben cares for her, Anna offers herself to him. To dissuade her, Ben is disingenuous and harsh. Anna finally gets in the bed alone, while Ben lies on the floor.The next day, Eugenio drives them to the Austrian border, as Weiss and Morales show up at Maria's looking for the gondolier with whom Anna and Ben were last seen. Maria tells them that Anna and Ben are married, which is reported to Anna's parents. Upset that Ben rejected her, Anna gets a ride on a truck, leaving Ben to", "neg": "Ever since the death of their teenage daughter Emily, Doug (James Gandolfini) and Lois (Melissa Leo) Riley have been drifting apart. Because of her grief, Lois has become a cold and distant agoraphobic. Doug begins an affair with Vivian, a younger local waitress. However, Lois manages to maintain her appearance and the presentation of her home despite never leaving and inviting no guests aside from her sister, Harriet. She has even already had headstones put next to their daughter's for them both and made funeral plans. One morning, Doug is informed that Vivian has died, and he travels to New Orleans on a business trip to clear his head. Instead, however, he ends up in a strip club where he meets 16-year-old stripper, Mallory (Kristen Stewart). He politely turns down her offer for a private dance and refuses any sexual contact, but instead accompanies her home and makes an unusual proposition: if Mallory will allow him to stay in her run-down house long enough to straighten himself out, he will pay her $100 a day for her trouble. For Mallory, who isn't used to getting money for doing nothing, it seems like a great deal. She accepts and Doug phones home to tell Lois he won't be coming home for a while. She tells him that she knew about his affair with Vivian but before the conversation can go any further, she hangs up. As time passes, Doug and Mallory settle into an unconventional kind of domesticity, and he becomes more of a father figure for her than anything else including teaching her how to make a bed properly and taking care of her money. Meanwhile, back home, Lois realizes that she'll have to act fast in order to save her marriage, even if that means venturing outside for the first time in nearly a decade. After a couple of attempts, Lois manages to start up her car and get on the freeway heading south. One night, Doug gets a call from Mallory who is in trouble after being robbed of the money she carries around by a client. He goes to pick her up and after arguing about how stupid she's being, he makes her realise that she needs to make some changes before things get worse. The following morning, Lois arrives in town and calls Doug to let him know, who is stunned that she not only left the house but drove all the way instead of flying. He immediately goes to meet her and they embrace one another for the first time in years. On the drive back, he tells her about Mallory (whose real name is Alison) and what she does for a living, which Lois instantly disapproves of. She is shocked to learn how young and foul-mouthed Mallory is. However, like Doug, Lois quickly warms to her due to her striking similarities to Emily. Before long, Lois has also moved in to Mallory's home and the three start to form an unconventional family. Lois helps her out with female problems and takes her shopping to buy suitable underwear, making her feel like a mother again, which she enjoys dearly. But later on when Lois attempts to steer Mallory from the path of self-destruction, the young girl flees. Mallory is then later arrested an altercation with a client, and Doug and Lois rush to be by her side, but shortly after they bail her out, she runs again. In that moment, Doug and Lois realize they cannot use Mallory as a substitute for their daughter and return home to Indianapolis. A few days later, Doug receives a phone call from Mallory in Houston. She looks cleaned up and healthier, and announces her plans about moving to Las Vegas, just before boarding the bus. Doug tells her that he and Lois will always be there for her.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}102{"query": "Every day when I enter the classroom, I will take a look at the wall beside my seat. You will find nothing special about this old wall if you just look at it. But for the students in my class, it is a special wall. Take a good look at it, and you will get to know the real feelings and thoughts of us, the 9th graders. In the middle of the wall, there is a big \"VICTORY\". It was written in pencil. I guess it must have been written by someone who got a good mark in an exam. A little higher above the formulas, there is a poem. It only has two sentences. It reads: All those sweet memories have disappeared. Like tears dropping in the heavy rain. Oh! It must have been written at the end of the last semester in middle school. Classmates had to leave school and good friends had to _ . What a sad poem! If you \"explore\" the wall more carefully, you will find many other interesting things, like a crying face, or a happy face, and other patterns . There are still some patterns and letters that I can't understand, but they all show the feeling of the students who drew them. For years, the wall has witnessed all the things that have happened in the classroom. I don't know how it will be next year, two years from now, or even ten years from now. But I hope more smiling faces will be drawn on it.", "pos": "In America, when the eighth graders leave the middle school, they are often worried about moving to the high school. It is a hard time for them, but it can be an exciting one as well. To make it easier, students need to get familiar with their school. Even though they've done this already in the middle school, it's still important to find where their classrooms are. Most schools take students to the high school for a visit at the end of their eighth grade year. And, most schools also have a freshman speech for parents and students before the first year begins. Sometimes the main office will give away a map of the school. This can help students and parents to find different places in the school. One way to know your high school more and make new friends is to join a club or play a sport. Schools often offer chances to join different clubs and sports. Fall activities begin in August before the first day of school. If you are not interested in sports, there are clubs for any interest, such as drama, dance, chess, photography, community service, etc. These clubs allow students from different grades. By joining an activity, students can find new friendships, not to mention improving their chances in future college applications . The school office will have a list of activities offered at the school and information on how to join them. What's more, to have a great start to a high school year, students can write down some of their worries, and ask for help from teachers and school workers.", "neg": "Has this ever happened to you? A student sitting next to you in class has a cold. The other student is coughing and sneezing, but you feel fine. Two days later, you come down with a cold, too. Diseases like colds are contagious. Contagious diseases are also called infectious diseases. An infectious disease is a disease that spreads from person to person. Infectious diseases are caused by pathogens. A pathogen is a living thing or virus that causes disease. Pathogens are commonly called germs. They can travel from one person to another. Living things that cause human diseases include bacteria, fungi, and protozoa. Most infectious diseases caused by these organisms can be cured with medicines. For example, medicines called antibiotics can cure most diseases caused by bacteria. Bacteria are one-celled organisms without a nucleus. Although most bacteria are harmless, some cause diseases. Worldwide, the most common disease caused by bacteria is tuberculosis (TB). TB is a serious disease of the lungs. Another common disease caused by bacteria is strep throat. You may have had strep throat yourself. Bacteria that cause strep throat are shown below ( Figure 1.1). Some types of pneumonia and many cases of illnesses from food are also caused by bacteria. The structures that look like strings of beads are bacteria. They belong to the genus Streptococcus. Bacteria of this genus cause diseases such as strep throat and pneumonia. They are shown here 900 times bigger than their actual size. Fungi are simple eukaryotic organisms that consist of one or more cells. They include mushrooms and yeasts. Human diseases caused by fungi include ringworm and athletes foot. Both are skin diseases that are not usually serious. A ringworm infection is pictured below ( Figure 1.2). A more serious fungus disease is histoplasmosis. It is a lung infection. Though fungal infections can be annoying, they are rarely as serious or deadly as bacterial or viral infections. Ringworm isnt a worm at all. Its a disease caused by a fungus. The fungus causes a ring-shaped rash on the skin, like the one shown here. Protozoa are one-celled organisms with a nucleus, making them eukaryotic organisms. They cause diseases such as malaria. Malaria is a serious disease that is common in warm climates. The protozoa infect people when they are bit by a mosquito. More than a million people die of malaria each year. Other protozoa cause diarrhea. An example is Giardia lamblia ( Figure 1.3). Viruses are nonliving collections of protein and DNA that must reproduce inside of living cells. Viruses cause many common diseases. For example, viruses cause colds and the flu. Cold sores are caused by the virus Herpes simplex This picture shows a one-celled organism called Giardia lamblia. It is a protozoan that causes diarrhea. ( Figure 1.4). Antibiotics do not affect viruses, because antibiotics only kill bacteria. But medicines called antiviral drugs can treat many diseases caused by viruses. Keep in mind that viruses are nonliving, so can they be killed? Different pathogens spread in different ways. Some pathogens spread through food. They cause food borne illnesses, which are discussed in a previous concept. Some pathogens spread through water. Giardia lamblia is one example. Water can be boiled to kill Giardia and most other pathogens. Several pathogens spread through sexual contact. HIV is one example, which is discussed in the next concept. Other pathogens that spread through sexual contact are discussed in a separate concept. Many pathogens that cause respiratory diseases spread by droplets in the air. Droplets are released when a person sneezes or coughs. Thousands of tiny droplets are released when a person sneezes ( Figure 1.5). Each droplet can contain thousands of pathogens. Viruses that cause colds and the flu can spread in this way. You may get sick if you breathe in the pathogens. As this picture shows, thousands of tiny droplets are released into the air when a person sneezes. Each droplet may carry thousands of pathogens. You cant normally see the droplets from a sneeze because they are so small. However, you can breathe them in, along with any pathogens they carry. This is how many diseases of the", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}103{"query": "At 60, rue des Archives, this Hotel de Guenegaud was built between 1651 and 1655 for Jean-Francois de Guenegaud des Brosses, secretaire du Roi, maitre des Comptes and conseiller d'Etat, by Francois Mansart (the only hotel particulier this architect built to have fully survived).", "pos": "The architect of Les Invalides was Liberal Bruant.", "neg": "He retired to the Villa Bianca (now named ''Villa Grock''), a 50-room house he had had built in the 1920s in Imperia, Italy, where he died in 1959.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}104{"query": "Last week I visited my friend Pete in the new home where he lives with his wife and daughter. Pete used to spend his holidays travelling the world, visiting the pyramids in Egypt or scuba diving in the Caribbean. Nowadays he prefers to spend his holidays and weekends making his house look more beautiful. Like hundreds of thousands of other British people, he has discovered the joy of DIY (Do It Yourself), which means if there are any things that need fixing around the house, he will try to do the job himself. As he showed me the new kitchen he put together by himself and the newly painted walls, I asked Pete where he got his inspiration from. He told me that his favorite source of ideas was a DIY program on TV. This got me thinking about the great popularity of DIY programs in the UK. Each major channel has at least one home or garden improving show and there's even a satellite channel completely about the subject. I guess it is not really surprising that DIY programs are so popular. Two common sayings in Britain- 'an Englishman's home is his castle' and 'there's no place like home'-show how important our houses are to us. With the present economic downturn, many people can't afford to buy a bigger house so they are looking at how they can make their house better without spending a lot of money. DIY is the perfect choice. But be careful! I read a report that said over 230,000 people were injured while doing home improvements in the UK in just one year, including 41,000 who fell off ladders and 5,800 who were seriously hurt by hammers. So I won't be going down to the hardware store.", "pos": "Britons spend as much as nearly five hours a week keeping their homes clean, a survey found. Kitchens are cleaned most often, while doing the oven and windows are the least popular jobs. In total, they spend just over PS1 billion a year on products to keep the dirt at bay -- almost PS40 per household. Market analyst Mintel found a clear division of labour. While the average Briton spends 4 hours, 40 minutes cleaning their home each week, men spend just 3 hours, 53 minutes compared to 5 hours, 25 minutes for women. And while seven in ten women say they do most of the cleaning, this falls to four in ten for men. Confirming many parents' feelings, only one in five adult children and over living at their parents' home helps with cleaning chores, with children under 18 doing even less. Last year, the household cleaning market was worth PS1.06 billion, which equates to annual spending of PS39.89 per household. Those looking for the cleanest homes in the country should head to Scotland, where people spend an average of five fours, 6 minutes, which is closely followed by East and West Midlands at five hours, 1 minute. In comparison, the least number of hours spent in cleaning is spent in the southeast/East Anglia at four hours, 18 minutes. The southwest and Wales stand at four hours, 46 minutes, the northwest four hours, 44 minutes, and Yorkshire and the Humber four hours, 21 minutes. According to Richard Caines, Mintel's senior household care analyst, men still lag women in the household cleaning stakes and spend on average an hour and a half less time cleaning their home, suggesting an opportunity for a campaign to encourage more cleaning by men to helpredressthis imbalance. The number of households that need cleaning is continuing to grow, but pressure on time from increasingly busy lives limits the number of hours people are willing or able to spend cleaning their homes. This means the market will see an increasing focus on easy-to-use, but effective hard surface cleaners and cleaning equipment. Such products can help encourage more cleaning to be done in less time, but as well as focusing on more convenient products, cleaning brands can also inject an element of fun into campaigns through encouraging a more shared approach that involves the whole family. This will also help to address the gender imbalance and get older children to make more of a contribution to cleaning.", "neg": "According to a survey released by the Nielson Company on Thursday, China has become a global tourist attraction after the Beijing Olympics. The survey said the Olympics not only built up China's image but also served as an advertisement for China's tourism. The online survey was conducted on consumers in 16 countries and regions before Games' opening ceremony and after the closing. About 80 percent of the respondents had not been to China before the events and 50 percent of them expressed hopes of visiting China after the Games. According to the survey, 70 percent of the respondents felt Beijing was more modern and scientific than what they had thought. The most interested respondents were from Singapore, India, Mexico, South Africa and the Republic of Korea, as well as China's Hong Kong and Taiwan. Pan Wen, in charge of Chinese tourism research of the Nielson Company, said the World Tourism Organization predicted that China would become the largest tourist attraction in the world with 137 million foreign tourists every year. \"This figure would be realized earlier with the aid of the Beijing Olympics,\" Pan said.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}105{"query": "Mathematical Models and Methods in Applied Sciences is a journal founded in 1991 and published by World Scientific.", "pos": "Advances in Adaptive Data Analysis (AADA) is an interdisciplinary scientific journal published by World Scientific.", "neg": "Mkuki na Nyota Publishers Ltd (MNP) is a book publishing company that was founded in 1991 in response to the general absence of independent scholarly publishing in Tanzania.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}106{"query": "A magnet is an object that attracts certain materials such as iron. Youre probably familiar with common bar magnets, like the one in Figure 24.2. Like all magnets, this bar magnet has north and south poles and attracts objects such as paper clips that contain iron. All magnets have two magnetic poles. The poles are regions where the magnet is strongest. The poles are called north and south because they always line up with Earths north-south axis if the magnet is allowed to move freely. (Earths axis is the imaginary line around which the planet rotates.) What do you suppose would happen if you cut the bar magnet in Figure 24.2 in half along the line between the north and south poles? Both halves would also have north and south poles. If you cut each of the halves in half, all those pieces would have north and south poles as well. Pieces of a magnet always have both north and south poles no matter how many times you cut the magnet. The force that a magnet exerts on certain materials is called magnetic force. Like electric force, magnetic force is exerted over a distance and includes forces of attraction and repulsion. North and south poles of two magnets attract each other, while two north poles or two south poles repel each other. Like the electric field that surrounds a charged particle, a magnetic field surrounds a magnet. This is the area around the magnet where it exerts magnetic force. Figure 24.3 shows the magnetic field surrounding a bar magnet. Tiny bits of iron, called iron filings, were placed under a sheet of glass. When the magnet was placed on the glass, it attracted the iron filings. The pattern of the iron filings shows the lines of force that make up the magnetic field of the magnet. The concentration of iron filings near the poles indicates that these areas exert the strongest force. To see an animated magnetic field of a bar magnet, go to this URL: [Link] When two magnets are brought close together, their magnetic fields interact. You can see how in Figure 24.4. The drawings show how lines of force of north and south poles attract each other whereas those of two north poles repel each other. The animations at the URL below show how magnetic field lines change as two or more magnets move in relation to each other. You can take an animated quiz to check your understanding of magnetic field interactions at this URL: [Link] Magnetism is the ability of a material to be attracted by a magnet and to act as a magnet. No doubt youve handled refrigerator magnets like the ones in Figure 24.5. You probably know first-hand that they stick to a metal refrigerator but not to surfaces such as wooden doors and glass windows. Wood and glass arent attracted to a magnet, whereas the steel refrigerator is. Obviously, only certain materials respond to magnetic force. Magnetism is due to the movement of electrons within atoms of matter. When electrons spin around the nucleus of an atom, it causes the atom to become a tiny magnet, with north and south poles and a magnetic field. In most materials, the electrons orbiting the nuclei of the atoms are arranged in such a way that the materials have no magnetic properties. Also, in most types of matter, the north and south poles of atoms point in all different directions, so overall the matter is not magnetic. Examples of nonmagnetic materials include wood, glass, plastic, paper, copper, and aluminum. These materials are not attracted to magnets and cannot become magnets. In other materials, electrons fill the orbitals of the atoms that make up the material in a way to allow for each atom to have a tiny magnetic field, giving each atom a tiny north and south pole. There are large areas where the north and south poles of atoms are all lined up in the same direction. These areas are called magnetic domains. Generally, the magnetic domains point in different directions, so the material is still not magnetic. However, the material can be magnetized by placing it in a magnetic field. When this happens, all the magnetic domains become aligned, and the material becomes", "pos": "A magnet is an object that attracts certain materials such as iron. Youre probably familiar with common bar magnets, like the one shown in the Figure 1.1. Like all magnets, this bar magnet has north and south magnetic poles. The red end of the magnet is the north pole and the blue end is the south pole. The poles are regions where the magnet is strongest. The poles are called north and south because they always line up with Earths north-south axis if the magnet is allowed to move freely. (Earths axis is the imaginary line around which the planet rotates.) Q: What do you suppose would happen if you cut the bar magnet pictured in the Figure 1.1 along the line between the north and south poles? A: Both halves of the magnet would also have north and south poles. If you cut each of the halves in half, all those pieces would have north and south poles as well. Pieces of a magnet always have both north and south poles no matter how many times you cut the magnet. The force that a magnet exerts on certain materials, including other magnets, is called magnetic force. The force is exerted over a distance and includes forces of attraction and repulsion. North and south poles of two magnets attract each other, while two north poles or two south poles repel each other. A magnet can exert force over a distance because the magnet is surrounded by a magnetic field. In the Figure 1.2, you can see the magnetic field surrounding a bar magnet. Tiny bits of iron, called iron filings, were placed under a sheet of glass. When the magnet was placed on the glass, it attracted the iron filings. The pattern of the iron filings shows the lines of force that make up the magnetic field of the magnet. The concentration of iron filings near the poles indicates that these areas exert the strongest force. You can also see how the magnetic field affects the compasses placed above the magnet. When two magnets are brought close together, their magnetic fields interact. You can see how they interact in the Figure 1.3. The lines of force of north and south poles attract each other whereas those of two north poles repel each other.", "neg": "A solenoid is a coil of wire with electric current flowing through it, giving it a magnetic field (see Figure 25.5). Recall that current flowing through a straight wire produces a weak electromagnetic field that circles around the wire. Current flowing through a coil of wire, in contrast, produces a magnetic field that has north and south poles like a bar magnet. The magnetic field around a coiled wire is also stronger than the magnetic field around a straight wire because each turn of the wire has its own magnetic field. Adding more turns increases the strength of the field, as does increasing the amount of current flowing through the coil. You can see an actual solenoid with a compass showing its magnetic north pole at this URL: . Solenoids are the basis of electromagnets. An electromagnet is a solenoid wrapped around a bar of iron or other ferromagnetic material (see Figure 25.6). The electromagnetic field of the solenoid magnetizes the iron bar by aligning its magnetic domains. The combined magnetic force of the magnetized iron bar and the wire coil makes an electromagnet very strong. In fact, electromagnets are the strongest magnets made. Some of them are strong enough to lift a train. The maglev train described earlier, in the lesson \"Electricity and Magnetism,\" contains permanent magnets. Strong electromagnets in the track repel the train magnets, causing the train to levitate above the track. Like a solenoid, an electromagnet is stronger if there are more turns in the coil or more current is flowing through it. A bigger bar or one made of material that is easier to magnetize also increases an electromagnets strength. You can see how to make a simple electromagnet at this URL: (4:57). MEDIA Click image to the left or use the URL below. URL: Many common electric devices contain electromagnets. Some examples include hair dryers, fans, CD players, telephones, and doorbells. Most electric devices that have moving parts contain electric motors. You can read below how doorbells and electric motors use electromagnets. Figure 25.7 shows a diagram of a simple doorbell. Like most doorbells, it has a button located by the front door. Pressing the button causes two electric contacts to come together and complete an electric circuit. In other words, the button is a switch. The circuit is also connected to a voltage source, an electromagnet, and the clapper of a bell. When current flows through the circuit, the electromagnet turns on, and its magnetic field attracts the clapper. This causes the clapper to hit the bell, making it ring. Because the clapper is part of the circuit, when it moves to strike the bell, it breaks the circuit. Without current flowing through the circuit, the electromagnet turns off. The clapper returns to its original position, which closes the circuit again and turns the electromagnet back on. The electromagnet again attracts the clapper, which hits the bell once more. This sequence of events keeps repeating as long as the button by the front door is being pressed. An electric motor is a device that uses an electromagnet to change electrical energy to kinetic energy. Figure 25.8 shows a simple diagram of an electric motor. The motor contains an electromagnet that is connected to a shaft. When current flows through the motor, the electromagnet turns, causing the shaft to turn as well. The rotating shaft moves other parts of the device. Why does the motors electromagnet turn? Notice that the electromagnet is located between the north and south poles of two permanent magnets. When current flows through the electromagnet, it becomes magnetized, and its poles are repelled by the like poles of the permanent magnets. This causes the electromagnet to turn toward the unlike poles of the permanent magnets. A device called a commutator then changes the direction of the current so the poles of the electromagnet are reversed. The reversed poles are once again repelled by the like poles of the permanent magnets. This causes the electromagnet to continue to turn. These events keep repeating, so the electromagnet rotates continuously. You can make a very simple electric motor with a battery, wire, and magnet following instructions at this URL: .", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}107{"query": "Three men, Red Pollard (Tobey Maguire), Charles S. Howard (Jeff Bridges), and Tom Smith (Chris Cooper) come together as the principal jockey, owner, and trainer of the championship horse Seabiscuit, rising from troubled times to achieve fame and success through their association with the horse. Red is the child of a Canadian family financially ruined by the Great Depression. In desperate need of money, the family leaves Red with a horse trainer. Red eventually becomes a jockey, but makes extra money through illegal boxing matches which left him blind in one eye. Howard is a clerk in a bicycle shop who gets asked by a passing motorist to repair his automobile, a technology which has recently been introduced. As a result, Howard becomes knowledgeable enough with automobiles to increase their performance and sell them as a dealer, eventually becoming the largest car dealer in California and one of the Bay Area's richest men. However, his son is killed in an automobile accident while driving the family car, which sends Howard into a bout of deep depression, which eventually results in his wife (Valerie Mahaffey) leaving him. On a trip to Mexico to obtain a divorce and to drown his sorrows, he meets Marcela Zabala (Elizabeth Banks). Marcela helps Howard overcome his depression, mainly through horse-riding. After marrying Marcela, Howard acquires a stable of horses and later has a chance encounter with the skilled and kindly horse trainer and drifter Smith. Howard hires Smith to manage his stables after Smith, who specializes in rehabilitating injured and abused horses, explains to Howard \"You don't throw a whole life away just 'cause it's banged up a little bit\". Smith convinces Howard to acquire the colt \"Seabiscuit\", who comes from noted lineage but had been deemed \"incorrigible\" by past handlers and was later broken and trained to lose against better horses. Smith is unable to find a jockey willing to deal with Seabiscuit's temperament, but after witnessing Red Pollard brawling with other stable boys, he sees in him a similar temperament to the feisty horse and decides to appoint him as Seabiscuit's jockey. Seabiscuit and Pollard become close and they begin to race. After overcoming early difficulties, such as a dismissive media and Pollard's anger issues and blind eye, Seabiscuit begins to earn considerable success and becomes an extremely popular underdog for the millions affected by the Great Depression. Inspired, Howard tries repeatedly to provoke a race with the mocking New York tycoon Samuel Riddle and his fearsome stallion \"War Admiral\", the top race horse in the country. Riddle eventually relents to a match race on his terms between War Admiral and Seabiscuit, but while the date approaches, Pollard is injured in a riding accident, fracturing his leg. When the doctor reports that he will be unable to ride again, Red suggests that Howard get an old friend, the successful jockey George Woolf (Gary Stevens) to be Seabiscuit's new rider. Red teaches Woolf about Seabiscuit's handling and mannerisms. At the match race, Seabiscuit upsets the heavy favorite, War Admiral, partly because of a secret that Pollard relates to Woolf, instructing him to hold him head to head with the other horse so he gets \"a good look at the Admiral.\" Later on, Seabiscuit is racing at Santa Anita when he is injured and has to stop. Red helps him to recover and get fit enough to race again. The last race is again at the Santa Anita, and Red rides him this time after putting a special self-made brace on his own leg to keep it stable. Woolf is on a different horse. Seabiscuit drops to last place and trails the pack, but Woolf holds back to be alongside Red and let Seabiscuit \"get a good look\". After a short conversation, Seabiscuit surges and wins the race. Red says, \"You know, everyone thinks that we found this broken down horse and fixed him, but we didn't. He fixed us. Every one of us. And I guess in a way, we kinda fixed each other, too.\"", "pos": "Harvey Shine (Dustin Hoffman) works as a jingle writer for television commercials in Manhattan, a job not in keeping with his one-time aspiration to be a jazz composer and pianist. We see him at work and he is very good at what he does. However, his boss does not seem impressed with his latest output. As Harvey departs for London to attend his daughter Susan's wedding, his boss actually suggests that he spend more time there than he had originally planned. Harvey declines, making the point that he needs to be back for an upcoming pitch to an old client. His boss insists that it is being done by other musicians, and that Harvey's latest work was his last chance to keep his job.On the plane, Harvey tries to chat up a fellow passenger, but she is having none of it. He is left sitting there with egg on his face and we come to regard him as even more of a loser.Meanwhile, we witness the mildly strained relationship between Kate Walker (Emma Thompson), a single Londoner, and her mother, whose husband left years earlier. Kate tries to reassure her mother that despite being single, she may yet find a man. Further, Kate tells her mom to quit worrying about the new Polish neighbor who has moved in next door and seems to be stacking a lot of firewood.Upon arrival at Heathrow Airport in London, Harvey encounters Kate at her job collecting statistics from passengers as they pass through the terminals. She attempts to question him about his reasons for visiting the UK. Tired and anxious to get to his hotel, Harvey brusquely dismisses her when she approaches him to ask questions.Harvey heads for the hotel to check in and discovers that he is the first one to arrive. Upon calling his daughter to double check where everyone else is when they were all supposed to be staying together, he learns that his ex-wife Jean actually rented a house to accommodate family and friends from the States and he is the only one at the hotel.After a brief nap, he showers and hurriedly dresses. On the way to the rehearsal dinner in the taxi cab, he realizes the anti-shoplifting device is still attached to the sleeve of his jacket. And to make matter worse, he has worn a white suit (thinking this was requested) while all the other men wore black. During the meal, it becomes increasingly clear Harvey is considered a mere guest and the role of father of the bride has been delegated to Jean's husband Brian. To add insult to injury, Brian stands to give the toast, and recollects the vacation they all spent in Rome, and his stepson-in-law-to-be embraces him and calls him Dad. Just before leaving back to his hotel, when Harvey tells Susan (with whom he has shared a strained relationship since his divorce) that he will be attending the ceremony but not the subsequent reception because he needs to return to the States for an important meeting, she informs him she has asked Brian to give her away.Meanwhile, Kate is set up on a blind date by a well meaning co-worker that does not go well. When she returns to the table after taking yet another call from her mother, she discovers her younger date has invited some of his younger friends to join them. Feeling unwanted and excluded from the conversation, she eventually excuses herself and goes home. As it turns out, Kate's increasingly neurotic mother seems convinced that her Polish neighbor is some kind of murderer because she sees him toting strange looking, lumpy packages into a shed in the back yard.The following morning Harvey attends Susan's wedding, but heavy traffic delays his arrival back to Heathrow, and he misses his plane. When he calls his boss Marvin in NYC to inform him he will be returning a day later than planned and that he will try to get there as soon as possible, he is told that he is fired.In his glum mood, Harvey makes his way to the airport bar and starts slugging down scotch, determined to drown his sorrows. Kate is sitting in the lounge reading", "neg": "Paul Stanton (Mulroney) and his wife Diane (Diane Kruger) are a couple whose daughter is dying from a rare degenerative lung condition. The only thing that can save her life is a lung transplant from an organ donor. The movie starts when the donated lung fails to arrive correctly. The movie goes back and forth between the present and the events leading up to it. In the present day, Paul goes to Juarez, Mexico to find a man called Dr. Navarro. After leaving his cell number at many local hospitals, somebody finally contacts Paul. In the past, Dr. Rubin (Arquette), who's treating their daughter (Stallard), had given them information regarding Paul's associate, Harrison (Shepard), who somehow managed to get an organ transplant for himself, possibly from the black market. Paul confronted Harrison and finally managed to get Dr. Navarro's name from him. Harrison told him that he was contacted by Navarro and he didn't know how to reach him. Back in the present day, Paul is ambushed by a couple of Navarro's guys that tell him to stay away. After an arduous search, Paul finally finds out that Dr. Navarro is actually Dr. Martinez (Perez) from a local hospital that he visited previously for his wounds. Paul confronts Martinez and asks him to find a lung donor for his daughter, who only has one week to live. Martinez agrees to help him for a $250,000 cash payment. The next day, Martinez tells Paul that he has found a matching donor for his daughter. Paul tells Diane to go to Juarez and prepare their daughter for the transplant operation. Little does Paul know that the donor is actually a live person; Martinez and his men have planned a hit-and-run accident to get the lung implant from a local street boy. Paul discovers this fact and tells Diane about it. Diane tells him that she does not want to know where the donor comes from. Paul confronts Martinez at the operating table. Martinez tells Paul to make a choice: to go ahead with the operation or disband the operation knowing that they won't be able to find another match in time to save his daughter's life. The next scene shows Paul and Diane at their daughter's funeral. Diane gives Paul an accusing look blaming him for their daughter's death. Meanwhile, elsewhere, the local boy that was supposed to be the organ donor is alive and playing soccer with his friends.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}108{"query": "Sleep disorders are frequent comorbidities in neurologic patients. This review focuses on clinical aspects and prognosis of 3 neurologic sleep disorders: narcolepsy, restless legs syndrome/Willis-Ekbom disease (RLS/WED), and REM sleep behavior disorder (RBD). Narcolepsy causes pervasive, enduring excessive daytime sleepiness, adversely affecting patients' daily functioning. RLS/WED is characterized by an uncomfortable urge to move the legs before sleep, often evolving toward augmentation and resulting in daylong bothersome symptoms. RBD causes potentially injurious dream enactment behaviors that often signify future evolution of overt synucleinopathy neurodegeneration in as many as 81% of patients. Timely recognition, referral for polysomnography, and longitudinal follow-up of narcolepsy, RLS/WED, and RBD patients are imperatives for neurologists in providing quality comprehensive patient care.", "pos": "Untreated sleep disorders may contribute to secondary causes of uncontrolled hypertension, cardiovascular disease (CVD), and stroke. Restless legs syndrome, or Willis-Ekbom Disease (RLS/WED), is a common sensorimotor disorder with a circadian rhythmicity defined by an uncontrollable urge to move the legs that worsens during periods of inactivity or at rest in the evening, often resulting in sleep disruptions. Sleep disorders such as insomnia and obstructive sleep apnea (OSA) are established risk factors for increased risk of hypertension and vascular diseases. This literature review outlines the lessons learned from studies demonstrating insomnia and OSA as risk factors for hypertension and vascular diseases to support the epidemiologic and physiologic evidence suggesting a similar increase in hypertension and vascular disease risk due to RLS. Understanding the relationships between RLS and hypertension, CVD, and stroke has important implications for reducing the risks associated with these diseases.", "neg": "To investigate whether the effects of nerve growth factor (NGF) inhibition with tanezumab on rats with medial meniscal tear (MMT) effectively model rapidly progressive osteoarthritis (RPOA) observed in clinical trials. Male Lewis rats underwent MMT surgery and were treated weekly with tanezumab (0.1, 1 or 10mg/kg), isotype control or vehicle for 7, 14 or 28days. Gait deficiency was measured to assess weight-bearing on the operated limb. Joint damage was assessed via histopathology. A second arm, delayed onset of treatment (starting 3-8weeks after MMT surgery) was used to control for analgesia early in the disease process. A third arm, mid-tibial amputation, evaluated the dependency of the model on weight-bearing. Gait deficiency in untreated rats was present 3-7days after MMT surgery, with a return to normal weight-bearing by days 14-28. Prophylactic treatment with tanezumab prevented gait deficiency and resulted in more severe cartilage damage. When onset of treatment with tanezumab was delayed to 3-8weeks after MMT surgery, there was no increase in cartilage damage. Mid-tibial amputation completely prevented cartilage damage in untreated MMT rats. These data suggest that analgesia due to NGF inhibition during the acute injury phase is responsible for increased voluntary weight-bearing and subsequent cartilage damage in the rat MMT model. This model failed to replicate the hypotrophic bone response observed in tanezumab-treated patients with RPOA.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}109{"query": "On an October morning in 1951, Norman Dale (Gene Hackman) drives through the Indiana countryside. In the afternoon he arrives in the small rural town of Hickory and enters the high school. He notices, on a shelf in the hall, basketball trophies won in previous years. As the bell rings to end the school day, he encounters teacher Myra Fleener (Barbara Hershey). She realizes that Norman must be the new basketball coach and teacher of history and civics. She directs him to the office of principal Cletus Summers (Sheb Wooley), where the two men recall how they met many years ago at Buffalo State Teachers College. They had lost touch until recently, when Cletus tracked down Norman and asked him to come coach at Hickory. When Norman thanks Cletus for the opportunity, Cletus interrupts and says, \"Your slate's clean here.\" They proceed to the gym, where student Jimmy Chitwood (Maris Valainis) is shooting baskets. Cletus introduces Norman, but Jimmy ignores the new coach and keeps shooting.That evening on his farm, Cletus explains to Norman that Jimmy has been strongly affected by the recent death of the previous coach, who was like a father to Jimmy. Now the young man has withdrawn from almost everything and everyone and has decided not to play basketball this season. Cletus adds that Jimmy is the best player he has ever seen. As they finish talking, Norman cryptically mentions that he hopes things will work out for him this time.That night, Norman meets some of the townsmen in the barbershop, who bombard him with questions. He tells them he last coached 12 years ago, in Ithaca, New York, and that he has been in the Navy for the past 10 years. The men voice their opinions on what Norman should do with the team. They all agree that Jimmy must rejoin the Huskers for them to have a winning season. Losing patience with all the questions and unwelcome advice, Norman cuts short the meet-and-greet and leaves.The next morning, before school begins, Myra tells Norman that Jimmy is her neighbor, and she has been looking out for him ever since his father died. She thinks it best that he stay off the team. After school, the Huskers are already practicing in the gym when Norman walks in. George Walker (Chelcie Ross), one of the townspeople Norman met in the barbershop, is leading the practice and assumes that Norman will continue allowing him to assist. When Norman brusquely makes it clear that he doesn't need any help, George storms off. As Norman gathers the seven Huskers and begins to introduce himself, Buddy (Brad Long) rudely whispers to his teammate Whit (Brad Boyle), who is standing next to him. Norman orders Buddy to leave, and Buddy convinces Whit to go with him. Jimmy is watching, unseen, at one of the far exits. Norman begins the practice and puts the Huskers through drills of passing, running in place, and dribbling while weaving between chairs; they never scrimmage. Norman explains, \"There's more to the game than shooting. There's fundamentals and defense.\" He also wants them to be in top physical condition because, if they continue to have only five players, substitutions and rest during games will be impossible. On the second day of practice, several townspeople walk in to observe; they've heard about Norman's unusual drills. Rollin Butcher (Robert Swan), Whit's father, brings in his son and has him apologize for walking out the day before. Rollin then tells the other men to leave, because the coach doesn't want them there.One day, as Cletus and Norman eat pie at the diner downtown, in comes Wilbur \"Shooter\" Flatch (Dennis Hopper), stumbling a bit and wearing a worn-out coat. Shooter, a former basketball player, describes for Norman how he almost led his team to victory in the 1933 sectional game of the tournament on a last-second shot. When Shooter asks Cletus in a low voice if he can borrow some spare change, Shooter's son, Everett (David Neidorf), who", "pos": "In 1957, when second-graders Bryce Loski and Julianna \"Juli\" Baker first meet, Juli knows it's love, but Bryce isn't so sure. Girl-phobic and easily embarrassed, young Bryce does everything he can to keep away as much as possible from Juli for the next six years, which isn't easy since they go to the same school and live across the street from each other. When they start the sixth grade, Bryce hopes that he can get rid of Juli so he asks the girl Juli hates the most, Shelly Stalls, out on a date. This plan of Bryce's works for a while up until his best friend, Garrett, takes an interest in Shelly and tells her the truth about Bryce asking her out. Juli finds out Bryce and Shelly break up; she goes back to her regular Bryce-obsessed self.From Juli's point of view, when she and Bryce first met, he returned her feelings but was just shy and embarrassed. When he \"held her hand\" she thought she would get her first kiss from him in the second grade. Juli knew that she was flipped from then on. After finding out that Bryce and Shelly broke up, she thought she could have her old Bryce back. She spent the whole year smelling his watermelon-scented hair and wondering if she'd ever get her kiss.In 1963, now in seventh grade, Bryce's grandfather Chet Duncan moves in with the family. Chet finds Juli different, special, and a rare kind of girl who's hard to come across. He continues to tell Bryce this with hope. There's a large, old sycamore tree that Juli loves which no one understands. One day, it's cut down by the owner in spite of Juli's protest and dismay. Her voice narrates her love for the tree that let her see the world in a much more enlightened way.Chet and Juli form a strong friendship over time while he helps her work on her messy lawn. Bryce begins to develop feelings for Juli just as Juli begins to question her feelings about Bryce. Her feelings completely disappear when she overhears him and Garrett talking about her mentally challenged uncle, and sees him throwing away the eggs she gave him. Juli tells Bryce she never wants to speak to him again when she and her family get invited to the Loski's house for a sit down dinner which ends up with Bryce's dad being considerably rude to her family. At the dinner she confronts him about what Bryce said about her uncle and tells him she doesn't want to speak to him again, not ever. During dinner, they sit opposite each other, she never talks or makes eye contact with him. After dinner she apologizes for the way she acted. Bryce is upset that she apologizes, because that means that she doesn't care enough to hold a grudge.She continues to have mixed feelings when the basket boy auction is just around the corner. She hears that Shelly is planning to bid on Bryce against another one of the school's \"finest\" girls. Bryce thinks that Juli is planning on bidding for him because he hears she walked in with a wad of cash (which she wasn't planning on having with her). Bryce begins to worry about what would happen if she does bid for him just when she bids all her cash on basket boy number eight, the boy before Bryce.Later, during the basket boy bidding lunch, Bryce and Shelly sit at a table across from Juli and basket boy number 8, Eddie Trulock. She's facing Bryce and he can't help but stare at Juli the whole time. He sees she's having a good time with her date and gets jealous. He grabs her to talk to her and attempts to kiss her in front of everyone. He chases her after she dodges his kiss. Juli gets on her bike and cycles as fast as she can home. Garrett chases after him, and the two break off their friendship after a confrontation.Juli bikes home crying. Bryce continuously tries to talk to her, ringing the doorbell, calling her house, coming to her bedroom", "neg": "Jonathan Shale (Berenger) is a mercenary and a Vietnam veteran who returns home to Miami after a botched covert operation in Cuba in which three men from his platoon were killed. He surprises his girlfriend, Jane Hetzko (Diane Venora) at her apartment and is warmly welcomed. On the outside, Jane is a schoolteacher at inner-city Columbus High School, an institution with a considerable gang problem. She is particularly disliked by Juan Lacas (Anthony), leader of the KOD (\"Kings of Destruction\") gang. While jogging one morning, Jane is attacked and has her leg broken. Jane and Shale believe this to be related to the KOD, which prompts the latter to go undercover as an Ivy League-educated, government-affiliated substitute teacher for his girlfriend's class. Shale arrives at Columbus High School and is, at first, taken back by the lowly conditions. He is unable to control his class of poorly-educated students on the first day, but decides to use his street-smarts and military tactics to gain the upper hand. Soon enough, he is able to take command of the students by displaying his combat self-defence techniques when students attack him. He is warned not to use such methods by Principal Claude Rolle (Hudson), but gains the respect of his students when he bonds with them over the similarities between his early gang and Vietnam War experiences and their involvement in petty crime and street gangs. During this time, he befriends fellow schoolteacher Darrell Sherman (Plummer) and also crosses paths with Lacas, one of his students. Suspicious of odd conditions within the high school, Shale sets up surveillance cameras throughout the building. He discovers that Lacas orchestrated the attack on Jane. He also discovers that Lacas is secretly working with Rolle to distribute cocaine around Miami for a major narcotics ring. Shale and his team raid a drug deal, using the stolen money to buy music and sports equipment in the form of a \"school donation.\" While Sherman initially denies Shale's discovery, Sherman and a female student inadvertently witness the drugs being loaded into one of the school buses later that day. Sherman tells the student to warn Shale and Hetzko, and sacrifices himself by creating a distraction. Rolle, who at this point is aware of Shale's interference orders a \"car accident\" for Shale, and sends Lacas after Hetzko. With the help of another student, Lacas is killed and Shale saves Hetzko, learning the full story from the female witness. Shale and his team garrison the school grounds to enter combat against the remaining K.O.D. members, a rival mercenary company led by Janus, and Rolle himself. Ultimately, Shale and Joey Six end up as the sole survivors of the battle, walking away from the school grounds discussing future operations as substitute teachers.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}110{"query": "Making Plans for Lena (French: Non ma fille, tu n'iras pas danser) is a 2009 French film directed by Christophe Honore, who co-wrote the screenplay with Genevieve Brisac.", "pos": "Escort in Love (Italian: Nessuno mi puo giudicare) is a 2011 Italian comedy film directed by Massimiliano Bruno.", "neg": "Anemone (born 9 August 1950) is a French actress, filmmaker and political activist.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}111{"query": "The major cause of outdoor air pollution is the burning of fossil fuels. Fossil fuels are burned in power plants, factories, motor vehicles, and home heating systems. Ranching and using chemicals such as fertilizers also cause outdoor air pollution. Erosion of soil in farm fields, mining activities, and construction sites adds dust particles to the air as well. Some specific outdoor air pollutants are described in Table 25.1. Air Pollutant Sulfur oxides Nitrogen oxides Carbon monoxide Carbon dioxide Particles (dust, smoke) Mercury Smog Ground-level ozone Source coal burning motor vehicle exhaust motor vehicle exhaust all fossil fuel burning wood and coal burning coal burning coal burning motor vehicle exhaust Problem acid rain acid rain poisoning global climate change respiratory problems nerve poisoning respiratory problems respiratory problems Outdoor air pollution causes serious human health problems. For example, pollutants in the air are major contributors to respiratory and cardiovascular diseases. Air pollution may trigger asthma attacks and heart attacks in people with underlying health problems. In fact, more people die each year from air pollution than automobile accidents. Air pollution may also cause acid rain. This is rain that is more acidic (has a lower pH) than normal rain. Acids form in the atmosphere when nitrogen and sulfur oxides mix with water in air. Nitrogen and sulfur oxides come mainly from motor vehicle exhaust and coal burning. If acid rain falls into lakes, it lowers the pH of the water and may kill aquatic organisms. If it falls on the ground, it may damage soil and soil organisms. If it falls on plants, it may make them sick or even kill them. Acid rain also damages stone buildings, bridges, and statues, like the one in Figure 25.1. Another major problem caused by air pollution is global climate change. Gases such as carbon dioxide from the burning of fossil fuels increase the greenhouse effect and raise Earths temperature. The greenhouse effect is a natural feature of Earths atmosphere. It occurs when certain gases in the atmosphere, including carbon dioxide, radiate the suns heat back down to Earths surface. Figure 25.2 shows how this happens. Without greenhouse gases in the atmosphere, the heat would escape into space. The natural greenhouse effect of Earths atmosphere keeps the planets temperature within a range that can support life. The rise in greenhouse gases due to human actions is too much of a good thing. It increases the greenhouse effect and causes Earths average temperature to rise. Rising global temperatures, in turn, are melting polar ice caps and glaciers. Figure 25.3 shows how much smaller the Arctic ice cap was in 2012 than it was in 1984. With more liquid water on Earths surface, sea levels are rising. Adding more heat energy to Earths atmosphere also causes more extreme weather and changes in precipitation patterns. Global warming is already causing food and water shortages and species extinctions. These problems will only grow worse unless steps are taken to curb greenhouse gases and global climate change. You may be able to avoid some of the health effects of outdoor air pollution by staying indoors on high-pollution days. However, some indoor air is just as polluted as outdoor air. One source of indoor air pollution is radon gas. Radon is a radioactive gas that may seep into buildings from rocks underground. Exposure to radon gas may cause lung cancer. Another potential poison in indoor air is carbon monoxide. It may be released by faulty or poorly vented furnaces or other fuel-burning appliances. Indoor furniture, carpets, and paints may release toxic compounds into the air as well. Other possible sources of indoor air pollution include dust, mold, and pet dander. Its easier to control the quality of indoor air than outdoor air. Steps home owners can take to improve indoor air quality include: keeping the home clean so it is as free as possible from dust, mold, and pet dander. choosing indoor furniture, flooring, and paints that are low in toxic compounds such as VOCs (volatile organic compounds). making sure that fuel-burning appliances are working correctly and venting properly. installing carbon monoxide alarms like the one in Figure 25.4 at every level of the home.", "pos": "Human health suffers in locations with high levels of air pollution. Different pollutants have different health effects: Lead is the most common toxic material and is responsible for lead poisoning. Carbon monoxide can kill people in poorly ventilated spaces, such as tunnels. Nitrogen and sulfur-oxides cause lung disease and increased rates of asthma, emphysema, and viral infections such as the flu. Ozone damages the human respiratory system, causing lung disease. High ozone levels are also associated with increased heart disease and cancer. Particulates enter the lungs and cause heart or lung disease. When particulate levels are high, asthma attacks are more common. By some estimates, 30,000 deaths a year in the United States are caused by fine particle pollution. Many but not all cases of asthma can be linked to air pollution. During the 1996 Olympic Games, Atlanta, Georgia, closed off their downtown to private vehicles. This action decreased ozone levels by 28%. At the same time, there were 40% fewer hospital visits for asthma. Can scientists conclude without a shadow of a doubt that the reduction in ozone caused the reduction in hospital visits? What could they do to make that determination? Lung cancer among people who have never smoked is around 15% and is increasing. One study showed that the risk of being afflicted with lung cancer increases directly with a persons exposure to air pollution (Figure 1.1). The study concluded that no level of air pollution should be considered safe. Exposure to smog also increased the risk of dying from any cause, including heart disease. One study found that in the United States, children develop asthma at more than twice the rate of two decades ago and at four times the rate of children in Canada. Adults also suffer from air pollution-related illnesses that include lung disease, heart disease, lung cancer, and weakened immune systems. The asthma rate worldwide is rising 20% to 50% every decade.", "neg": "Air quality is a measure of the pollutants in the air. More pollutants mean poorer air quality. Air quality, in turn, depends on many factors. Some natural processes add pollutants to the air. For example, forest fires and volcanoes add carbon dioxide and soot. In dry areas, the air often contains dust. However, human actions cause the most air pollution. The single biggest cause is fossil fuel burning. Poor air quality started to become a serious problem after the Industrial Revolution. The machines in factories burned coal. This released a lot of pollutants into the air. After 1900, motor vehicles became common. Cars and trucks burn gasoline, which adds greatly to air pollution. By the mid-1900s, air quality in many big cities was very bad. The worst incident came in December 1952. A temperature inversion over London, England, kept cold air and pollutants near the ground. The air became so polluted that thousands of people died in just a few days. This event was called the Big Smoke. At the same time, many U.S. cities had air pollution problems. Some of the worst were in California. Cars were becoming more popular. Oil refineries and power plants also polluted the air. Mountain ranges trapped polluted air over cities. The California sunshine caused chemical reactions among the pollutants. These reactions produced many more harmful compounds. By 1970, it was clear that something needed to be done to protect air quality. In the U.S., the Clean Air Act was passed. It limits what can be released into the air. As a result, the air in the U.S. is much cleaner now than it was 50 years ago. But air pollution has not gone away. Vehicles, factories, and power plants still release more than 150 million tons of pollutants into the air each year. There are two basic types of pollutants in air. They are known as primary pollutants and secondary pollutants. Primary pollutants enter the air directly. Some are released by natural processes, like ash from volcanoes. Most are released by human activities. They pour into the air from vehicles and smokestacks. Several of these pollutants are described below. Carbon oxides include carbon monoxide (CO) and carbon dioxide (CO2 ). Carbon oxides are released when fossil fuels burn. Nitrogen oxides include nitric oxide (NO) and nitrogen dioxide (NO2 ). Nitrogen oxides form when nitrogen and oxygen combine at high temperatures. This occurs in hot exhausts from vehicles, factories, and power plants. Sulfur oxides include sulfur dioxide (SO2 ) and sulfur trioxide (SO3 ). Sulfur oxides are produced when sulfur and oxygen combine. This happens when coal burns. Coal can contain up to 10 percent sulfur. Toxic heavy metals include mercury and lead. Mercury is used in some industrial processes. It is also found in fluorescent light bulbs. Lead was once widely used in gasoline, paint, and pipes. It is still found in some products. Volatile organic compounds (VOCs) are carbon compounds such as methane. VOCs are released in many human activities, such as raising livestock. Livestock wastes produce a lot of methane. Particulates are solid particles. These particles may be ash, dust, or even animal wastes. Many are released when fossil fuels burn (see Figure 22.1). Secondary pollutants form when primary pollutants undergo chemical reactions after they are released. Many occur as part of photochemical smog. This type of smog is seen as a brown haze in the air. Photochemical smog forms when certain pollutants react together in the presence of sunlight. You can see smog hanging in the air over San Francisco in Figure 22.2. Photochemical smog consists mainly of ozone (O3 ). The ozone in smog is the same compound as the ozone in the ozone layer,(O3 ). But ozone in smog is found near the ground. Figure 22.3 shows how it forms. When nitrogen oxides and VOCs are heated by the Sun, they lose oxygen atoms. The oxygen atoms combine with molecules of oxygen to form ozone. Smog ozone is harmful to humans and other living things. Most pollutants enter the air when fossil fuels burn. Some are released when forests burn.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}112{"query": "During the major economic depression of the early 1890s, the Pullman Palace Car Company cut wages in its factories. Discontented workers joined the American Railway Union , led by Eugene V. Debs, which supported their strike by launching a boycott of all Pullman cars on all railroads. ARU members across the nation refused to switch Pullman cars onto trains. When these switchmen were disciplined, the entire ARU struck the railroads on June 26, 1894. Within four days, 125,000 workers on twenty-nine railroads had people quit work rather than handle Pullman cars. Strikers and their supporters also engaged in riots and sabotage. The railroads were able to get Edwin Walker, general counsel for the Chicago, Milwaukee, and St. Paul Railway, appointed as a special federal attorney with responsibility for dealing with the strike. Walker went to federal court and obtained an injunction barring union leaders from supporting the boycott in any way. The court injunction was based on the Sherman Anti-Trust Act which prohibited \"Every contract, combination in the form of trust or otherwise, or conspiracy, in restraint of trade or commerce among the several States\". Debs and other leaders of the ARU ignored the injunction, and federal troops were called into action. The strike was broken up by United States Marshals and some 2,000 United States Army troops, commanded by Nelson Miles, sent in by President Grover Cleveland on the premise that the strike interfered with the delivery of U.S. Mail. During the course of the strike, 13 strikers were killed and 57 were wounded. An estimated $340,000 worth of property damage occurred during the strike. Debs went to prison for six months for violating the federal court order, and the ARU disintegrated.", "pos": "In 1908 the U.S. Supreme Court decided Loewe v. Lawlor . In 1902 the Hatters' Union instituted a nationwide boycott of the hats made by a nonunion company in Connecticut. Owner Dietrich Loewe brought suit against the union for unlawful combinations to restrain trade in violation of the Sherman Antitrust Act. The Court ruled that the union was subject to an injunction and liable for the payment of triple damages. In 1915 Justice Oliver Wendell Holmes, speaking for the Court, again decided in favor of Loewe, upholding a lower federal court ruling ordering the union to pay damages of $252,130. . This was not a typical case in which a few union leaders were punished with short terms in jail; specifically, the life savings of several hundreds of the members were attached. The lower court ruling established a major precedent, and became a serious issue for the unions. The Clayton Act of 1914 presumably exempted unions from the antitrust prohibition and established for the first time the Congressional principle that \"the labor of a human being is not a commodity or article of commerce\". However, judicial interpretation so weakened it that prosecutions of labor under the antitrust acts continued until the enactment of the Norris-La Guardia Act in 1932.", "neg": "The French Revolution broke out in 1789. At the time France was in a crisis. The government was badly run and people's lives were miserable. King Louis XIV tried to control the national parliament and raise more taxes. But his effort failed. He ordered his troops to Versailles. The people thought that Louis intended to put down the Revolution by force. On July 14, 1789, they stormed and took the Bastille, where political prisoners were kept. Ever since that day, July 14 has been the French National Day. Louis tried to flee the country in 1792, to get support from Austria and Prussia. However, he was caught and put in prison. In September 1792, the monarchy was abolished _ . In the same year, Louis was executed. A few months later his wife, Marie also had her head cut off. The Revolution of France had frightened the other kings of Europe. Armies from Austria and Prussia began to march against France. The French raised republican armies to defend the nation. The Revolution went through a period of terror. Thousands of people lost their lives. In the end, power passed to Napoleon Bonaparte.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}113{"query": "The Chargers' fourteenth game was an interconference duel with the 49ers which was played on Thursday Night. The Chargers took a quick lead with QB Philip Rivers throwing a 58-yard TD pass to WR Vincent Jackson. The lead was extended in the second quarter by kicker Nate Kaeding nailing a 25-yard field goal, followed by Rivers finding Jackson on an 11-yard touchdown pass. The Chargers continued to dominate with FB Mike Tolbert getting a 1-yard TD run, followed by Rivers connecting to Jackson on a 48-yard TD pass, then with Kaeding hitting a 39-yard field goal. The 49ers made their only score of the game with RB Brian Westbrook getting a 1-yard TD run. This game was also a blowout and San Diego improved to 8-6.", "pos": "Coming off their bye week, the Jets stayed at home for a Week 10 duel with the Jacksonville Jaguars. New York would trail early in the first quarter with running back Maurice Jones-Drew's 33-yard touchdown run. The Jets would respond with kicker Jay Feely getting a 32-yard field goal, followed by rookie quarterback Mark Sanchez completing a 7-yard touchdown pass to wide receiver Jerricho Cotchery. In the second quarter, Jacksonville would take the lead as quarterback David Garrard got an 11-yard touchdown run and completed a 26-yard touchdown pass to wide receiver Mike Sims-Walker. New York would close out the half as Feely made a 37-yard field goal. After a scoreless third quarter, the Jets would regain the lead in the fourth quarter with a 40-yard field goal from Feely and a 1-yard touchdown run from running back Thomas Jones (with a failed 2-point conversion). However, the Jaguars got the last laugh as kicker Josh Scobee booted the game-winning 21-yard field goal.", "neg": "The Chiefs took an early lead on a 30-yard pass from Tyler Thigpen to Mark Bradley. The Chiefs defense continued to show improvement in the red zone, limiting the Chargers to two field goals instead of two touch downs. At the end of the first half, Thigpen threw a pass to 34yard touchdown pass to Tony Gonzalez. However, the extra point snap was botched and an attempt at a quick pass failed. The Chargers controlled the second half better than the first, scoring two touchdowns and leading the Chiefs by 7 at the end of the fourth quarter. The Chiefs' final drive ended with a 3-yard touchdown pass to Gonzalez. A 1-point PAT would tie the game. However, Herm Edwards told Thigpen to go for two, explaining in a post-game interview that the defense was too beat up for overtime play. The resulting two-point conversion ended in an incomplete pass. The Chiefs lost by one point.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}114{"query": "The figure of a limp woman with long curly hair is seen drifting underwater, and a voiceover questions the end of a life that never truly existed. This life ended in murder, the victim herself unsure of who her killer was and why she was killed. Her death was only metaphorical, for in her place a new life begins.The story starts with Patience Phillips (Halle Berry), a timid woman who can't stand up for herself. She lets people walk all over her, and has wasted her artistic talent working for a cosmetic company as a graphic designer. George Hedare (Lambert Wilson) runs the company with his supermodel wife, Laurel (Sharon Stone). Laurel knows that Patience is capable, but seems mostly indifferent, only using her in own power struggles with her husband. George, an abusive boss in general, finds plenty of opportunity to mock Laurel.The company is about to launch BeauLine, a new anti-aging product that Laurel had secretly been using for years. The advertisement is designed by Patience but George, unsatisfied, demands that she redesigns it. Upset and frustrated, Patience returns home and sees a cat looking up at her. Shaking her head, she goes to sleep, but her loud neighbours keeps her up and she is unable to rest. Next morning, the cat is on her window ledge. When she approaches, she realizes the cat has climbed up to a higher ledge and was potentially stuck. To try and reach the cat, Patience climbs out her window ledge, and a passing detective mistakens her intentions as suicidal. He ends up rushing into her apartment and pulling her back in. Patience would have thanked him but realizes she is late for work, in her hurry to leave she drops her wallet. The detective, Tom Lone (Benjamin Bratt), tracks her down to her workplace and returns it to her, and both agree to a coffee date.Later that night, Patience goes to the production factory to deliver her artwork, and she accidentally hears that the BeauLine has unsafe health problems. Stunned, she backs into several tools, revealling her presence. Two men chase her into a large waste water pipe, where she is trapped, and they flush her into the river, where she drowns. The cat that has been appearing in front of Patience appears by her body and gathers several other cats around her.Patience eventually drags herself unsteadily up and returns home. Her movements are off and uncontrollable, and she ends up breaking the glass through her own window. When her neighbours start their usual loud party again, she yells at them to quiet but they again ignore her. The old Patience would have backed down, but now she strodes down, knocks on their door, and promptly beats up the host and destroys the music equipment in front of many shocked guests. When she wakes up the next morning, she almost dismisses everything as a dream until she sees the broken glass. Unfortunately, her memories of what happened before that are blank, and so she cluelessly returns back to work.At work, George loudly yells at Patience in front of all her coworkers for not handling in her project. She tunes him out, which angers him further, and when she apologizes he only continues. Patience than apologizes for wasting her time in the company, and is fired, but as soon as George leaves her colleagues swarm around her in congratulations. Patience packs up her things and while she and her friends are walking home, two dogs instantly begin barking at her and she instinctively hisses at them. When questioned, she explains her behaviour as allergies. When they pass by a jewelry store, Patience's attention is caught by a beautiful collar-like necklace, but is reminded of her new unemployed status and leaves longingly. Once home, she sees the same cat again, and finally close enough she was able to find the address on the cat's owner.The cat belonged to an older woman named Ophelia, a former professor who lived alone in a house full of cats. She explains that the cat constantly appearing in front of Patience is named Midnight, a rare Egyptian", "pos": "Darma (Pierre Andre) is traumatised by the mysterious death of his fiancee, Rose (Intan Ladyana) who had killed herself. Unknown to him, Rose had been haunted by a malicious spirit which they had brought to her home after picking up a small jar found washed up at the beach. Apparently, the spirit had been imprisoned and was inadvertently released by the couple.At her home, after her death, before leaving Darma had taken the small jar with him, and with it, the malignant spirit.Not satisfied with why Rose had suddenly killed herself, Darma decides to investigate the case with the help of Rose's twin sister, Seri, (also played by Intan Ladyana). As they probe into the death, a series of strange occurrences start to unravel, leaving Darma in a disturbed state of mind that affects his life and career. When he is advised to take a week's break from work, he returns to his village to rest. Unknown to him, he is only getting closer to solving his fiancee's death and the truth behind the strange happenings.It was Darma's senile grandmother who could see the ghost and had unwittingly invited the spirit into the house. In Malay belief, certain spirits cannot enter the house unless invited in. This is similar to the vampire mythology in the West. The ghost in this movie is called Saka. Saka was a ghost that has been kept by the elder for some uncertified reason. Mostly, Saka starts to give problems when it's owner die and Saka needs to be feed. Mostly, Saka will haunt the next generation of the owner.", "neg": "Private investigator Patrick Kenzie (Casey Affleck) and his partner/girlfriend Angie Gennaro (Michelle Monaghan) witness a televised plea by a woman named Helene McCready (Amy Ryan) for the return of her missing daughter Amanda, who was abducted with her favorite doll \"Mirabelle\". Patrick and Angie are then hired by the child's aunt Beatrice (Amy Madigan) to find Amanda and discover that Helene and her boyfriend \"Skinny Ray\" (Sean Malone) had recently stolen money from Cheese (Edi Gathegi), a local Haitian drug lord. After Ray is murdered, Patrick and Angie join the police detectives Remy Bressant (Ed Harris) and Nick Poole (John Ashton) with investigating the case and assist in arranging the trade of money for the return of Amanda. Captain Jack Doyle (Morgan Freeman) reads Patrick a telephone transcript of the drug lord setting up an exchange for Amanda. The exchange at a nearby quarry in Quincy is botched and it is believed Amanda drowned; her doll is found in the quarry and returned to Helene. Doyle, whose own daughter was killed years before, takes responsibility for the death and goes into early retirement. Two months later, a seven year old boy is abducted in Everett and Patrick receives information that the boy was taken by a known child molester. After entering the suspect's house and finding evidence of the abducted boy, Patrick returns with Remy and Nick to rescue him. They are seen by the residents and Nick is shot. Patrick enters the house during the shootout and finds one of the residents dead. He retreats into the child molester's room, where he finds the boy's dead body; he then shoots the child molester in the back of the head in a fit of rage. Nick later dies of his wounds. Trying to alleviate Patrick's guilt over the events at the house, Remy unthinkingly confides that he once planted evidence on someone with the help of \"Skinny Ray\" whom he had initially told Patrick he didn't know. After Nick's funeral, Patrick speaks to a police officer, who tells him that Remy had been asking about the drug lord's stolen money before the drug lord knew it was missing. Patrick then questions Beatrice's husband Lionel (Titus Welliver) in a bar and pieces together that Lionel and Remy had conspired to stage a fake kidnapping in order to take the drug money for themselves and to take Amanda from her neglectful mother's care. At that point, Remy (trying to cover for his earlier mistake) enters the bar, while wearing a latex mask and holding a shotgun, and stages a robbery. He points the shotgun at Lionel's head, but the bartender shoots Remy twice in the back. Remy flees and is pursued by Patrick to the rooftop of a nearby building, where he dies. Patrick is questioned by the police about Remy's death and learns that the police never had a phone transcript like the one that Doyle had read to him prior to the botched exchange. Patrick and Angie drive to Doyle's home, where Patrick finds Amanda living with Doyle and his wife; Doyle was part of the phony kidnapping all along. Patrick threatens to call the authorities, but Doyle attempts to convince him that Amanda is better off living with them than with her mother, and that is reason enough not to get involved. Patrick leaves and discusses the choices with Angie, who says she will leave him if he calls the police, since she also believes Amanda is much better off with the Doyles. In the next scene, the police arrive, Doyle is arrested, Amanda is returned to her mother amidst heavy publicity, and Patrick and Angie break up. Patrick later visits Amanda as Helene is about to leave on a date with someone she met during the publicity over her daughter's disappearance. Helene informs Patrick that Beatrice has been forbidden to visit and is upset about her husband's arrest. Helene has no babysitter for Amanda and when asked, she tells Patrick that Helene's friend, Dottie (Jill Quigg) will watch her, even though she has yet to ask Dottie herself. Patrick volunteers to watch Amanda, who is holding her", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}115{"query": "Captain Jack Harkness is a fictional character played by John Barrowman in Doctor Who and its spin-off series, Torchwood.", "pos": "Adam Park is a fictional major character from the universe of the American television series franchise Power Rangers, played by Johnny Yong Bosch.", "neg": "A Viking boy called Hiccup (voice: Jay Baruchel) introduces his village of Berk (\"it's been here for seven generations, but every single building is new\"). The village is attacked by dragons, who steal food (mostly sheep) and set things on fire (hence all the new buildings). The villagers grab weapons and try to fight the dragons off. Despite being told by every adult in sight to go indoors, Hiccup hauls out a bolas-shooting cannon he made himself and shoots a dragon out of the night sky. (As assistant to the village blacksmith, Gobber (voice: Craig Ferguson), Hiccup has access to tools and materials and knows how to use them.) The dragon lands in the woods some distance form the village and no one believes that he hit anything, so it's the next day before Hiccup can go looking for it. It turns out to be a rare and deadly Night Fury, but Hiccup can't make himself kill it. Instead he releases it -- whereupon it also refrains from killing Hiccup -- and it flies off through the trees.Hiccup discovers that the dragon (which he eventually calls Toothless because of its retractable teeth) has holed up in a steep-sided valley because it can no longer fly more than a few feet at a time. While sketching the dragon, Hiccup realizes that it's missing a tail fin. He makes a prosthetic tail fin out of leather. The new fin helps, but Toothless can't control it and inadvertently takes Hiccup for a ride, giving him a clear idea of what's needed to help the dragon fly right. In a series of workshop and test flight scenes, Hiccup builds and perfects a saddle, a control mechanism for the tail fin, and a safety harness.Meanwhile, Hiccup's father Stoick (voice: Gerard Butler) has signed him up for dragon training with Gobber, which is very different from the training he's already doing with Toothless: he's going to learn to fight dragons. At first, he's the worst student in the class. Since Hiccup has always been an accident-prone klutz, this comes as no surprise to his classmates Astrid (voice: America Ferrera), Snotlout (voice: Jonah Hill), Fishlegs (voice: Christopher Mintz-Plasse), Ruffnut (voice: Kristen Wiig), and her twin brother Tuffnut (voice: T.J. Miller). (Hiccup's a little sweet on Astrid.) Before long, Hiccup is able to use some things he's learned while working with Toothless to soothe and manage the school's practice dragons. (It turns out dragons are just big kitty-cats: they like to be petted, there's a kind of grass that's like cat-nip to them, and they love fish (but hate eels).) When Stoick returns from a failed search for the fabled nest of the dragons, he's surprised but thrilled to hear that his son is doing brilliantly at dragon training. He gives Hiccup a horned helmet made from one of his dead mother's breastplates. But Hiccup, as usual, is unable to get around his father's expectations and speak frankly, so he can't explain that his success at dragon school is unlikely to lead to the slaying of any dragons.When Hiccup subdues a practice dragon, unintentionally earning the privilege of killing it before the entire village, he's horrified and decides to flee with Toothless. However Astrid, having noticed Hiccup's frequent disappearances and secretive behavior, is suspicious. She follows him to the hidden valley and sees Toothless. Unable to explain his relationship with the dragon, Hiccup takes her flying, and she's captivated. But they get caught up in a flock of dragons returning to their nest carrying food. The dragons fly inside a mountainous island and drop the food into a pit, which turns out to contain a huge, terrifying, and very hungry dragon that eats the smaller ones if they don't bring it enough food. Hiccup and Astrid and shocked to realize that the dragons have been stealing their sheep to keep from being eaten themselves. When they get home,", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}116{"query": "Fred Fish died at his home in Idaho on Friday April 20, 2007 of a heart attack.", "pos": "Ivan Francescato died suddenly of a heart attack at 3 a.m. at his home in Treviso.", "neg": "Esporte Clube Corinthians played their home games at Estadio Eduardo Jose Farah, nicknamed Farahzao.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}117{"query": "What do temperature, clouds, winds, and rain have in common? They are all part of weather. Weather refers to the conditions of the atmosphere at a given time and place. Weather occurs because of unequal heating of the atmosphere. The source of heat is the Sun. The general principles behind weather can be stated simply: The Sun heats Earths surface more in some places than others. Where it is warm, heat from the Sun warms the air close to the surface. If there is water at the surface, it may cause some of the water to evaporate. Warm air is less dense, so it rises. When this happens, more dense air flows in to take its place. The flowing surface air is wind. The rising air cools as it goes higher in the atmosphere. If it is moist, the water vapor may condense. Clouds may form, and precipitation may fall. The water cycle plays an important role in weather. When liquid water evaporates, it causes humidity. When water vapor condenses, it forms clouds and precipitation. Humidity, clouds, and precipitation are all important weather factors. Humidity is the amount of water vapor in the air. High humidity increases the chances of clouds and precipitation. Humidity usually refers to relative humidity. This is the percent of water vapor in the air relative to the total amount the air can hold. How much water vapor can the air hold? That depends on temperature. Warm air can hold more water vapor than cool air. You can see this in Figure 16.1. People often say, its not the heat but the humidity. Humidity can make a hot day feel even hotter. When sweat evaporates, it cools your body. But sweat cant evaporate when the air already contains as much water vapor as it can hold. The heat index is a measure of what the temperature feels like because of the humidity. You can see the heat index in Figure 16.2. Youve probably noticed dew on the grass on a summer morning. Why does dew form? Remember that the land heats up and cools down fairly readily. So when night comes, the land cools. Air that was warm and humid in the daytime also cools over night. As the air cools, it can hold less water vapor. Some of the water vapor condenses on the cool surfaces, such as blades of grass. The temperature at which water vapor condenses is called the dew point. If this temperature is below freezing, ice crystals of frost form instead of dew. As you can see in Figure 16.1, the dew point occurs at 100 percent relative humidity. Can you explain why? Clouds form when air in the atmosphere reaches the dew point. Clouds may form anywhere in the troposphere. Clouds that form on the ground are called fog. Clouds form when water vapor condenses around particles in the air. The particles are specks of matter, such as dust or smoke. Billions of these tiny water droplets come together to make up a cloud. If the air is very cold, ice crystals form instead of liquid water. Clouds are classified on the basis of where and how they form. Three main types of clouds are cirrus, stratus, and cumulus. Figure 16.3 shows these and other types of clouds. Cirrus clouds form high in the troposphere. Because it is so cold they are made of ice crystals. They are thin and wispy. Cirrus clouds dont usually produce precipitation, but they may be a sign that wet weather is coming. Stratus clouds occur low in the troposphere. They form in layers that spread horizontally and may cover the entire sky like a thick blanket. Stratus clouds that produce precipitation are called nimbostratus. The prefix nimbo- means rain. Cumulus clouds are white and puffy. Convection currents make them grow upward and they may grow very tall. When they produce rain, they are called cumulonimbus. Clouds can affect the temperature on Earths surface. During the day, thick clouds block some of the Suns rays. This keeps the surface from heating up as much as it would on a clear day. At night, thick clouds prevent", "pos": "The movement of water around Earths surface is the hydrological (water) cycle (Figure 1.1). Water inhabits reservoirs within the cycle, such as ponds, oceans, or the atmosphere. The molecules move between these reservoirs by certain processes, including condensation and precipitation. There are only so many water molecules and these molecules cycle around. If climate cools and glaciers and ice caps grow, there is less water for the oceans and sea level will fall. The reverse can also happen. The following section looks at the reservoirs and the processes that move water between them. The Sun, many millions of kilometers away, provides the energy that drives the water cycle. Our nearest star directly impacts the water cycle by supplying the energy needed for evaporation. Most of Earths water is stored in the oceans, where it can remain for hundreds or thousands of years. Water changes from a liquid to a gas by evaporation to become water vapor. The Suns energy can evaporate water from the ocean surface or from lakes, streams, or puddles on land. Only the water molecules evaporate; the salts remain in the ocean or a fresh water reservoir. The water vapor remains in the atmosphere until it undergoes condensation to become tiny droplets of liquid. The droplets gather in clouds, which are blown about the globe by wind. As the water droplets in the clouds collide and grow, they fall from the sky as precipitation. Precipitation can be rain, sleet, hail, or snow. Sometimes precipitation falls back into the ocean and sometimes it falls onto the land surface. When water falls from the sky as rain it may enter streams and rivers that flow downward to oceans and lakes. Water that falls as snow may sit on a mountain for several months. Snow may become part of the ice in a glacier, where it may remain for hundreds or thousands of years. Snow and ice may go directly back into the air by sublimation, the process in which a solid changes directly into a gas without first becoming a liquid. Although you probably have not seen water vapor undergoing sublimation from a glacier, you may have seen dry ice sublimate in air. Snow and ice slowly melt over time to become liquid water, which provides a steady flow of fresh water to streams, rivers, and lakes below. A water droplet falling as rain could also become part of a stream or a lake. At the surface, the water may eventually evaporate and reenter the atmosphere. A significant amount of water infiltrates into the ground. Soil moisture is an important reservoir for water (Figure The moisture content of soil in the United States varies greatly. Water may seep through dirt and rock below the soil and then through pores infiltrating the ground to go into Earths groundwater system. Groundwater enters aquifers that may store fresh water for centuries. Alternatively, the water may come to the surface through springs or find its way back to the oceans. Plants and animals depend on water to live. They also play a role in the water cycle. Plants take up water from the soil and release large amounts of water vapor into the air through their leaves (Figure 1.3), a process known as transpiration. People also depend on water as a natural resource. Not content to get water directly from streams or ponds, humans create canals, aqueducts, dams, and wells to collect water and direct it to where they want it (Figure 1.4). Clouds form above the Amazon Rainfor- est even in the dry season because of moisture from plant transpiration. Pont du Gard in France is an ancient aqueduct and bridge that was part of of a well-developed system that supplied wa- ter around the Roman empire. Click image to the left or use the URL below. URL:", "neg": "How well soil forms and what type of soil forms depends on several different factors, which are described below. Scientists know that climate is the most important factor determining soil type because, given enough time, different rock types in a given climate will produce a similar soil (Figure 1.1). Even the same rock type in different climates will not produce the same type of soil. This is true because most rocks on Earth are made of the same eight elements and when the rock breaks down to become soil, those elements dominate. The same factors that lead to increased weathering also lead to greater soil formation. More rain equals more chemical reactions to weather minerals and rocks. Those reactions are most efficient in the top layers of the soil, where the water is fresh and has not yet reacted with other materials. Increased rainfall increases the amount of rock that is dissolved as well as the amount of material that is carried away by moving water. As materials are carried away, new surfaces are exposed, which also increases the rate of weathering. Climate is the most important factor in determining the type of soil that will form in a particular area. Increased temperature increases the rate of chemical reactions, which also increases soil formation. In warmer regions, plants and bacteria grow faster, which helps to weather material and produce soils. In tropical regions, where temperature and precipitation are consistently high, thick soils form. Arid regions have thin soils. Soil type also influences the type of vegetation that can grow in the region. We can identify climate types by the types of plants that grow there. The original rock is the source of the inorganic portion of the soil. The minerals that are present in the rock determine the composition of the material that is available to make soil. Soils may form in place or from material that has been moved. Residual soils form in place. The underlying rock breaks down to form the layers of soil that reside above it. Only about one-third of the soils in the United States are residual. Transported soils have been transported in from somewhere else. Sediments can be transported into an area by glaciers, wind, water, or gravity. Soils form from the loose particles that have been transported to a new location and deposited. The steeper the slope, the less likely material will be able to stay in place to form soil. Material on a steep slope is likely to go downhill. Materials will accumulate and soil will form where land areas are flat or gently undulating. Soils thicken as the amount of time available for weathering increases. The longer the amount of time that soil remains in a particular area, the greater the degree of alteration. The partial decay of plant material and animal remains produces the organic material and nutrients in soil. In soil, decomposing organisms breakdown the complex organic molecules of plant matter and animal remains to form simpler inorganic molecules that are soluble in water. Decomposing organisms also create organic acids that increase the rate of weathering and soil formation. Bacteria in the soil change atmospheric nitrogen into nitrates. The decayed remains of plant and animal life are called humus, which is an extremely important part of the soil. Humus coats the mineral grains. It binds them together into clumps that then hold the soil together, creating its structure. Humus increases the soils porosity and water-holding capacity and helps to buffer rapid changes in soil acidity. Humus also helps the soil to hold its nutrients, increasing its fertility. Fertile soils are rich in nitrogen, contain a high percentage of organic materials, and are usually black or dark brown in color. Soils that are nitrogen poor and low in organic material might be gray or yellow or even red in color. Fertile soils are more easily cultivated. Click image to the left or use the URL below. URL:", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}118{"query": "A mechanical wave is a disturbance in matter that transfers energy from place to place. A mechanical wave starts when matter is disturbed. An example of a mechanical wave is pictured in Figure 19.1. A drop of water falls into a pond. This disturbs the water in the pond. What happens next? The disturbance travels outward from the drop in all directions. This is the wave. A source of energy is needed to start a mechanical wave. In this case, the energy comes from the falling drop of water. The energy of a mechanical wave can travel only through matter. This matter is called the medium (plural, media). The medium in Figure 19.1 is a liquid the water in the pond. But the medium of a mechanical wave can be any state of matter, including a solid or a gas. Its important to note that particles of matter in the medium dont actually travel along with the wave. Only the energy travels. The particles of the medium just vibrate, or move back-and- forth or up-and-down in one spot, always returning to their original positions. As the particles vibrate, they pass the energy of the disturbance to the particles next to them, which pass the energy to the particles next to them, and so on. There are three types of mechanical waves. They differ in how they travel through a medium. The three types are transverse, longitudinal, and surface waves. All three types are described in detail below. A transverse wave is a wave in which the medium vibrates at right angles to the direction that the wave travels. An example of a transverse wave is a wave in a rope, like the one pictured in Figure 19.2. In this wave, energy is provided by a persons hand moving one end of the rope up and down. The direction of the wave is down the length of the rope away from the persons hand. The rope itself moves up and down as the wave passes through it. You can see a brief video of a transverse wave in a rope at this URL: . To see a transverse wave in slow motion, go to this URL: (0:22). MEDIA Click image to the left or use the URL below. URL: A transverse wave can be characterized by the high and low points reached by particles of the medium as the wave passes through. This is illustrated in Figure 19.3. The high points are called crests, and the low points are called troughs. Another example of transverse waves occurs with earthquakes. The disturbance that causes an earthquake sends transverse waves through underground rocks in all directions from the disturbance. Earthquake waves that travel this way are called secondary, or S, waves. An S wave is illustrated in Figure 19.4. A longitudinal wave is a wave in which the medium vibrates in the same direction that the wave travels. An example of a longitudinal wave is a wave in a spring, like the one in Figure 19.5. In this wave, the energy is provided by a persons hand pushing and pulling the spring. The coils of the spring first crowd closer together and then spread farther apart as the disturbance passes through them. The direction of the wave is down the length of the spring, or the same direction in which the coils move. You can see a video of a longitudinal wave in a spring at this URL: http A longitudinal wave can be characterized by the compressions and rarefactions of the medium. This is illustrated in Figure 19.6. Compressions are the places where the coils are crowded together, and rarefactions are the places where the coils are spread apart. Earthquakes cause longitudinal waves as well as transverse waves. The disturbance that causes an earthquake sends longitudinal waves through underground rocks in all directions from the disturbance. Earthquake waves that travel this way are called primary, or P, waves. They are illustrated in Figure 19.7. A surface wave is a wave that travels along the surface of a medium. It combines a transverse wave and a longitudinal wave. Ocean waves are surface waves. They travel on the surface of the water between the ocean", "pos": "The waves in the picture above are examples of mechanical waves. A mechanical wave is a disturbance in matter that transfers energy through the matter. A mechanical wave starts when matter is disturbed. A source of energy is needed to disturb matter and start a mechanical wave. Q: Where does the energy come from in the water wave pictured above? A: The energy comes from the falling droplets of water, which have kinetic energy because of their motion. The energy of a mechanical wave can travel only through matter. The matter through which the wave travels is called the medium (plural, media). The medium in the water wave pictured above is water, a liquid. But the medium of a mechanical wave can be any state of matter, even a solid. Q: How do the particles of the medium move when a wave passes through them? A: The particles of the medium just vibrate in place. As they vibrate, they pass the energy of the disturbance to the particles next to them, which pass the energy to the particles next to them, and so on. Particles of the medium dont actually travel along with the wave. Only the energy of the wave travels through the medium. There are three types of mechanical waves: transverse, longitudinal, and surface waves. They differ in how particles of the medium move. You can see this in the Figure 1.1. In a transverse wave, particles of the medium vibrate up and down perpendicular to the direction of the wave. In a longitudinal wave, particles of the medium vibrate back and forth parallel to the direction of the wave. In a surface wave, particles of the medium vibrate both up and down and back and forth, so they end up moving in a circle. Q: How do you think surface waves are related to transverse and longitudinal waves? A: A surface wave is combination of a transverse wave and a longitudinal wave.", "neg": "Wave speed is the distance a wave travels in a given amount of time, such as the number of meters it travels per second. Wave speed (and speed in general) can be represented by the equation: Speed = Distance Time Wave speed is related to both wavelength and wave frequency. Wavelength is the distance between two correspond- ing points on adjacent waves. Wave frequency is the number of waves that pass a fixed point in a given amount of time. This equation shows how the three factors are related: Speed = Wavelength x Wave Frequency In this equation, wavelength is measured in meters and frequency is measured in hertz (Hz), or number of waves per second. Therefore, wave speed is given in meters per second, which is the SI unit for speed. Q: If you increase the wavelength of a wave, does the speed of the wave increase as well? A: Increasing the wavelength of a wave doesnt change its speed. Thats because when wavelength increases, wave frequency decreases. As a result, the product of wavelength and wave frequency is still the same speed. Click image to the left or use the URL below. URL: The equation for wave speed can be used to calculate the speed of a wave when both wavelength and wave frequency are known. Consider an ocean wave with a wavelength of 3 meters and a frequency of 1 hertz. The speed of the wave is: Speed = 3 m x 1 wave/s = 3 m/s Q: Kim made a wave in a spring by pushing and pulling on one end. The wavelength is 0.1 m, and the wave frequency is 2 hertz. What is the speed of the wave? A: Substitute these values into the equation for speed: Speed = 0.1 m x 2 waves/s = 0.2 m/s The equation for wave speed (above) can be rewritten as: Frequency = Speed Wavelength or Wavelength = Speed Frequency Therefore, if you know the speed of a wave and either the wavelength or wave frequency, you can calculate the missing value. For example, suppose that a wave is traveling at a speed of 2 meters per second and has a wavelength of 1 meter. Then the frequency of the wave is: Frequency = 2m/s 1m = 2 waves/s, or 2 Hz Q: A wave is traveling at a speed of 2 m/s and has a frequency of 2 Hz. What is its wavelength? A: Substitute these values into the equation for wavelength: Wavelength = 2m/s 2waves/s =1m The speed of most waves depends on the medium, or the matter through which the waves are traveling. Generally, waves travel fastest through solids and slowest through gases. Thats because particles are closest together in solids and farthest apart in gases. When particles are farther apart, it takes longer for the energy of the disturbance to pass from particle to particle through the medium. Click image to the left or use the URL below. URL:", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}119{"query": "Inflammation plays an important role in the pathophysiology of atherosclerosis and endothelial dysfunction, and occurs after percutaneous coronary intervention (PCI). We evaluated whether endothelial function is attenuated after PCI and if inhibition of secretory phospholipase A2 (sPLA2) activity augments endothelial function and coronary flow reserve (CFR) in these patients. In the sPLA2 Inhibition to Decrease Enzyme Release After Percutaneous Coronary Intervention (SPIDER-PCI) study, patients undergoing elective PCI were randomized to receive Varespladib (Anthera Pharmaceuticals Inc, San Mateo, CA), an inhibitor of sPLA2, or placebo 3-5 days prior to PCI and for 5 days after PCI. In this substudy, endothelial function was assessed in 31 patients by flow-mediated dilation (FMD) before treatment and on the day after PCI, while taking study medication. During the PCI procedure, CFR was assessed using a Doppler guide wire. Baseline and procedural characteristics were comparable in both groups and sPLA2 activity was similar at baseline. After PCI, sPLA2 activity decreased only in the Varespladib group (2.9 0.9 to 0.5 0.4 ng/mL), and high-sensitivity C-reactive protein (hsCRP) increased by more than 100% in both groups. FMD at baseline was 3.66 2.45% (Varespladib) and 3.37 1.73% (placebo) with nonsignificant increase in both groups after PCI. The effect of Varespladib on FMD, adjusted for pre-PCI FMD by linear regression, was -1.16 1.68%; P = 0.5. CFR was 2.45 0.66 and 2.77 0.85 in the Varespladib and placebo groups, respectively (P = 0.36). Systemic endothelial function is not reduced after elective PCI despite eliciting acute inflammatory response. Acute inhibition of sPLA2 activity with Varespladib does not affect endothelial or microvascular function after PCI.", "pos": "High circulating levels of group IIA secretory phospholipase A2 (sPLA2-IIA) activity and mass are independent cardiovascular risk factors. Therefore, inhibition of sPLA2-IIA may be a target for the treatment of atherosclerotic cardiovascular disease. The present study evaluated the effects of sPLA2-IIA inhibition with varespladib acid in a novel mouse model, human apolipoprotein B (apoB)/human cholesteryl ester transfer protein (CETP)/human sPLA2-IIA triple transgenic mice (TTT) fed a Western-type diet. sPLA2-IIA expression increased atherosclerotic lesion formation in TTT compared with human apoB/human CETP double transgenic mice (P<0.01). Varespladib acid effectively inhibited plasma sPLA2-IIA activity. Surprisingly, however, administration of varespladib acid to TTT had no impact on atherosclerosis, which could be attributed to a proatherogenic plasma lipoprotein profile that appears in response to sPLA2-IIA inhibition because of increased plasma CETP activity. In the TTT model, sPLA2-IIA decreased CETP activity by reducing the acceptor properties of sPLA2-IIA-modified very low-density lipoproteins specifically because of a significantly lower apoE content. Increasing very low-density lipoprotein-apoE content by means of adenovirus-mediated gene transfer in sPLA2-IIA transgenic mice restored the acceptor properties for CETP. These data show that in a humanized triple transgenic mouse model with hypercholesterolemia, sPLA2-IIA inhibition increases CETP activity via increasing the very low-density lipoprotein-apoE content, resulting in a proatherogenic lipoprotein profile.", "neg": "ESSENTIALS: When high probability of pulmonary embolism (PE), sensitivity of computed tomography (CT) is unclear. We investigated the sensitivity of multidetector CT among 134 patients with a high probability of PE. A normal CT alone may not safely exclude PE in patients with a high clinical pretest probability. In patients with no clear alternative diagnosis after CTPA, further testing should be strongly considered. Whether patients with a negative multidetector computed tomographic pulmonary angiography (CTPA) result and a high clinical pretest probability of pulmonary embolism (PE) should be further investigated is controversial. This was a prospective investigation of the sensitivity of multidetector CTPA among patients with a priori clinical assessment of a high probability of PE according to the Wells criteria. Among patients with a negative CTPA result, the diagnosis of PE required at least one of the following conditions: ventilation/perfusion lung scan showing a high probability of PE in a patient with no history of PE, abnormal findings on venous ultrasonography in a patient without previous deep vein thrombosis at that site, or the occurrence of venous thromboembolism (VTE) in a 3-month follow-up period after anticoagulation was withheld because of a negative multidetector CTPA result. We identified 498 patients with a priori clinical assessment of a high probability of PE and a completed CTPA study. CTPA excluded PE in 134 patients; in these patients, the pooled incidence of VTE was 5.2% (seven of 134 patients; 95% confidence interval [CI] 1.5-9.0). Five patients had VTEs that were confirmed by an additional imaging test despite a negative CTPA result (five of 48 patients; 10.4%; 95% CI 1.8-19.1), and two patients had objectively confirmed VTEs that occurred during clinical follow-up of at least 3 months (two of 86 patients; 2.3%; 95% CI 0-5.5). None of the patients had a fatal PE during follow-up. A normal multidetector CTPA result alone may not safely exclude PE in patients with a high clinical pretest probability.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}120{"query": "A new study suggests that listening to music in the office improves the speed and accuracy of tasks such as data entry, proof reading and problem solving. In an office-based experiment, 88 per cent of participants were found to produce their most accurate work when listening to music. The study also found that 81 per cent completed their fastest work when music was played. And it matters what type of music you listen to. For instance, if you're doing your tax returns, then classical music is the most effective as it improves maths skills. Listening to Jessie Jor Justin Bieber could also improve your speed, with 58 per cent of participants completing data entry tasks faster while listening to pop songs. During proof-reading, dance music, such as David Guetta, had the biggest positive impact with participants increasing their speed by 20 per cent compared to tests undertaken with no music at all. Dance music also had a positive effect on spell-checking with a 75 per cent pass rate compared to 68 per cent when no music was played at all. The research, undertaken by Brighton-based Mind lab International, suggests that silent offices may be the least productive. 'The Music Works experiment revealed a positive _ between music and productivity - overall it showed that when listening to music, nine out of 10 people performed better,' said Dr David Lewis, chairman of Mind lab International.", "pos": "Have you ever thought about why malls, restaurants, and even theaters have music? Well, to understand this, you simply just look back at how you felt when you heard music in these places. Music is known to improve the mood of people. Often music helps us pay attention to what we are doing. Music helps patients feel good and helps them recover faster and better. Depression is a state of mind that most of us experience at some point of time. There are some periods in our life when everything seems difficult. It seems that everything is getting worse and we have no control over our life. Studies have shown that music can be an important mood lifter in such situations. Music also plays a great role in making us feel less nervous or worried. Anxiety can often cause loss of sleep and other illnesses. Music is often known as an international language. We may not know the language another person is speaking, but most of us respond to music in the same way. Music can often be the best way to connect with someone. Music is one of the best ways to improve your moods, but this can depend largely on the kind of music you listen to. While happy music can certainly make you feel better, sad music can further lower your spirits. Listening to classical music can often make you feel a lot more powerful, while soft music can be the perfect way to relax at the end of a long way. If you want to use music to change the way how you are feeling, you need to understand the role of it, learn to recognize the kind of music that lifts your mood and helps you feel better. Once you realize the kind of music you can use, you can use it to change the way you feel. The right kind of music can be the perfect way to help us feel happier.", "neg": "Young people frequently say that they want to exercise, but they just can't find the time. The solution just might be in-office interval training. Recent studies show that very short but intense exercise rapidly builds and maintains fitness and health, even when the workout is only a few minutes long. Work the stairs You can complete an excellent, effective -- and very brief -- workout in an office stairwell, says Martin Gibala, a professor of kinesiology at McMaster University in Canada and an expert on interval training. For a study that he and his colleagues presented earlier this year, they asked 12 out-of-shape women in their 20s to warm up for two minutes by slowly walking up and down stairs in a campus office building. They completed three of these abbreviated stair workouts per week for six weeks. By the end, their aerobic fitness had improved substantially, the researchers reported, by about as much as if they had been running or cycling each week for hours. Fidget your way to fitness. Parents and teachers may once have urged you to sit still, but wiggling, tapping your toes, standing briefly, and otherwise fidgeting as much as possible at your desk is in fact good for your body. In one recent study, college students showed healthier blood flow in their lower legs if they fidgeted than if they did not. Even better, a 2008 study found that among office workers, those who frequently fidgeted burned as many as 300 calories more each day than those who resolutely stayed still.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}121{"query": "The film opens as Alice Melbourne and Judson Ellis arrive at a California Municipal Airport by taxi. Alighting from the cab they tip the driver generously, bribing him to not say anything to anyone about them. Alice and Judson check the departure sign for The Silver Queen, heading for Panama City, Panama, and seem excited and anxious.Also waiting for the same flight is Peggy Nolan, to whom a delivery of expensive flowers is made with a card thanking her for some favor. Peggy disdainfully tosses the card in the trash and gives the flowers to a woman selling cheap gardenias.Soon after, the flight gets ready to leave and we are introduced to Professor and Mrs. Spengler, an elderly couple, and Joe, the flight's co-pilot, who is immediately attracted to Alice. Mrs. Spengler is a domineering woman, but her husband seems content to be bossed around like a child.As they wait on the tarmac near the 'plane a car drives up and a well dressed man emerges with a young boy and another man. The boy is Tommy and he is being sent away with \"Uncle\" Pete until his father -- a mobster -- can follow later.As the passengers board, Bill, the pilot, receives word that they will be transporting an anarchist back to Panama, but he assures the group there is nothing to worry about since the man will be in custody during the flight. The prisoner is Vasquez, and is being accompanied by a bounty hunter named Crimp.After Larry the steward helps everyone get settled, the flight departs with its twelve souls aboard. Bill and Joe discuss plans for the layover and Joe indicates he has an interest in Alice. He goes back to the passenger compartment where beds have been made up and people are turning in for the night -- except for Crimp who plans to stay up and make sure Vasquez doesn't \"go for a walk\" -- thus cheating the hangman and himself out of $5,000.Pete tucks his young charge in for the night and helps him say his prayers (something Pete is unfamiliar with). Peggy comes up to the cockpit to visit with Bill, whose rudeness finally makes it clear that he wants nothing to do with her. When Alice rings for the steward, Joe takes the call and makes a play for her.Next morning the 'plane arrives for a refueling stop in Mexico and the passengers have breakfast. Joe continues to pursue Alice, under the assumption that she is Judson's secretary. Peggy makes another stab at getting Bill to warm to her and is rebuffed again. Then Pete tells her that her help isn't needed when she tries to get Tommy to drink his milk. Peggy's been \"marked\" as a loose woman by her fellow travelers who want nothing to do with her.Before boarding the 'plane a reporter confronts Judson and Alice and Joe learns that she is engaged to her \"boss\" and they are eloping.As the flight continues and heads into stormy weather the Professor discusses the methods by which a South American tribe of headhunters practice their craft. The conversation is interrupted by a news bulletin which recounts how Tommy's father has been killed. Peggy again tries to help with Tommy, saying \"he needs a woman.\" But Pete is still being judgemental and answers \"he needs a lady.\" Mrs. Spengler intervenes and comforts Tommy.As the storm they are flying through gets rougher, the passengers strap themselves into their seats and Crimp insists the pilots turn back. As the 'plane rocks back and forth a couple of metal cylinders break loose and crash through the back door. Tommy comes perilously close to going out the door when Llarry saves him and hands him to Pete. Just then the 'plane dips sharply and Larry is tossed out the door to his death. As Joe and Bill try to steady the 'plane Crimp tries to force them to turn back by waving his gun at them. In the struggle the gun goes off and is picked up by Vasquez.With a damaged engine the Silver Queen crashes, and all eleven on board survive. The next morning Joe and Bill admit to the professor that they were blown off", "pos": "(Because the film has a very complicated plot and features many characters, the events will be told mostly in chronological order to render the plot clearer, rather than strictly adhering to the order we see in the film.)General Sternwood has two daughters: the elder one is Vivian (Lauren Bacall) and the younger one is Carmen, who is a carefree, childish and problematic young woman.General Sternwood has a man named Sean Regan working for him. With the help of Sean, the general has made a man named Joe Brody leave Carmen alone, by giving him 5.000 Dollars.Carmen loves Sean but Sean loves the wife of a man named Eddie Mars, so he refuses Carmens advances. One day, Carmen kills Sean when she is drunk because of her unrequited love. Eddie hides Seans body. He then makes up the story that Sean and his wife have run away together and nobody sees Sean after that day. To support this story, he actually makes his own wife go away and start living in a remote place. Even the general doesnt know Seans whereabouts and wonders why he has left all of a sudden. Eddie then proceeds to blackmail Vivian for Carmens murder. As a way of eliciting money from Vivian, Eddie makes her win big money at his gambling house with cheats, and then he takes all the money from her.Carmens troublesome adventures are not over, though. A man named Arthur Gwynn Geiger blackmails General Sternwood to take the gambling debts of Carmen. The general hires Philip Marlowe (Humphrey Bogart) to get rid of Geigers blackmail. Vivian talks to Marlowe, thinking that her father has actually hired him to find Sean Regan. Afraid that Carmen may get into trouble, she tries to take words from Marlowes mouth about his inquiry. But she learns that her father has not actually hired Marlowe about Sean.Marlowe goes to Geigers so-called antique books shop and sees a woman named Agnes, who makes it impossible for him to talk to Geiger. Then Marlowe waits at the bookshop across the street until the evening and follows Geiger and his right arm Carol Lundgren to Geigers house. Before Marlowe gets in the house, however, important things happen. Owen Taylor, driver for the Sternwoods, is in love with Carmen. He goes to Geigers house with her and kills Geiger for her. A secret camera, however, takes Carmens photo just at the moment of the murder. Owen then takes the film from the hidden camera, gets in the car and goes away. Joe Brody, also present that night, follows Owen, takes the film from him to blackmail Carmen, (and most probably) kills Owen and pushes his car in the water.When Marlowe gets in Geigers house, he sees Carmen with the dead body of Gaiger lying on the ground. Marlowe takes Carmen home and tells Vivian to say that Carmen has been home all night if asked by anyone. When he goes back to Geigers house, he sees that his dead body has been taken away.Later, Owens dead body is found in the car in the water. He has been killed before falling into the water. Marlowe learns from Vivian that Owen was interested in Carmen. Vivian then tells Marlowe that somebody is blackmailing her for Carmens photo taken at the night of Geigers murder. The blackmailer, who wants 5.000 Dollars, is actually Agnes. It is Joe Brody that makes her blackmail Vivian. Vivian tells Marlowe that she can take the money from Eddie.When Marlowe meets with Carmen once again at Geigers house, she tells him that it was Joe who took her photo that night. Eddie comes along and tries to scare Marlowe out of his inquiries.Later, Marlowe finds Joe Brody and questions him about Geiger. Agnes and Vivian are also at his house. Carmen comes along with a gun and threatens to kill Joe if he doesnt give her the photo. Carmen takes the photo and she leaves with Vivian. Then the doorbell rings again and somebody kills Joe, then escapes. Marlowe catches the man, who turns out to be Carol (Geigers right arm), who thinks that it was Joe who killed Geiger. Marlowe and Carol then go to", "neg": "Early one morning, a taxi pulls up at Tiffany & Co. on Fifth Avenue in New York City, from which elegantly dressed Holly Golightly (Audrey Hepburn) emerges. After looking into the shop's windows, she strolls home. Outside her apartment, she fends off Sid Arbuck (Claude Stroud), her date from the disastrous night before. Later, she is awakened by new neighbor Paul Varjak (George Peppard), ringing her doorbell to get into the building. The pair chat as she dresses to leave for her weekly visit to Sally Tomato (Alan Reed), a mobster incarcerated at Sing Sing prison. Tomato's lawyer, O'Shaughnessy, pays her $100 a week to deliver \"the weather report\". Audrey Hepburn as Holly Golightly As she is leaving for Sing Sing, Holly is introduced to Paul's \"decorator\", wealthy older woman Emily Eustace Failenson (Patricia Neal), whom Paul nicknames \"2E\". That night, Holly goes out onto the fire escape to elude an over-eager date (Mel Blanc). She peeks into Paul's apartment and sees 2E leaving money and kissing Paul goodbye. After 2E leaves, Holly enters Paul's apartment and learns that he is a writer who has not had anything published since a book of vignettes five years before. Holly, in turn, explains that she is trying to save money to support her brother Fred when he gets out of the Army. The pair fall asleep, but are awakened when Holly has a nightmare about Fred. She later buys Paul a typewriter ribbon to apologize and invites him to a party at her apartment. There, Paul meets her Hollywood agent, O. J. Berman (Martin Balsam), who describes Holly's transformation from country girl into Manhattan socialite. He is also introduced to Jose da Silva Pereira (Jose Luis de Vilallonga), a wealthy Brazilian politician, and Rusty Trawler (Stanley Adams), the \"ninth richest man in America under 50.\" In the days that follow, Paul and Holly become closer. One day, 2E enters Paul's apartment, worried that she is being followed. Paul tells her that he will investigate and eventually confronts Doc Golightly (Buddy Ebsen), Holly's estranged husband. Doc explains that Holly's real name is Lula Mae Barnes. They married when she was 13, and he wants to take her back to Texas, as Fred will be returning. After Paul reunites Holly and Doc, she tells Paul the marriage was annulled. At the bus station, she tells Doc she is not going with him. Doc leaves broken-hearted. After drinking at a club, Paul and Holly return to her apartment, where she drunkenly tells him that she plans to marry Trawler for his money. A few days later, Paul learns that one of his short stories will be published. On the way to tell Holly, he sees a newspaper headline stating that Trawler has married someone else. Holly and Paul agree to spend the day together, taking turns doing things that each has never done before. At Tiffany's, Paul has the ring from Doc Golightly's box of Cracker Jack engraved as a present for Holly. After spending the night together, he awakens to find her gone. When 2E arrives, Paul ends their relationship. She calmly accepts, having earlier concluded that he and Holly are in love. Holly schemes to marry Jose for his money, which angers Paul. After Holly receives a telegram notifying her of Fred's death, she trashes her apartment. Months later, Paul has moved out. He is invited to dinner by Holly, who is leaving the next morning for Brazil to continue her relationship with Jose. However, they are arrested in connection with Sally Tomato's drug ring, and Holly spends the night in jail. The next morning, Holly is released on bail and finds Paul waiting, and they take a cab. He has her cat and a letter from Jose explaining he must end their relationship due to her arrest. Holly insists she will go to Brazil anyway, asks the cab to pull over, and releases the", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}122{"query": "Rick Riker (Drake Bell) is an unpopular student at Empire High with his only friend Trey (Kevin Hart), living with his uncle Albert (Leslie Nielsen) and Aunt Lucielle (Marion Ross). His crush Jill Johnson (Sara Paxton), who hardly notices him, is dating Rick's bully Lance Landers (Ryan Hansen). Rick and Trey are then shown to be on a school trip to an animal research lab. In the lab Rick meets Lou Landers (Christopher McDonald) who coughs up blood because he is terminally ill. Dr. Strom, the head researcher at the lab, then shows his seven mutated dragonflies, though there are only six there because one has escaped which then bites Rick, and causes his neck to swell.The scene then goes to Rick's house where his Aunt Lucille and Uncle Albert are talking on the couch when Rick comes in. He is very sick, and throws up in a fish tank because of his illness and goes up to his room. Albert and Lucille believe Rick is acting strange, so Albert proceeds to talk to Rick. Rick then passes out from the bite.He wakes up the next morning, with a strange video sent to him from a man wanting to speak to him, later adding Rick as a friend on Facebook. Meanwhile, Lou Landers gets into a scientific accident, transforming into the Hourglass who feeds on human life. At a science fair, with a comically rude and mean-spirited Stephen Hawking who gets physically hurt throughout the film, Rick gets into mishaps, such as becoming stuck to water fountains. He then realizes he has superpowers such as the ability to walk on walls, has incredible strength, but cannot fly. He tests his strength in an alleyway, then decides to test how he can walk up walls. He climbs up and begins to break dance, then has a lie-down on the wall and a cat walks up the wall beside him. He then sees an old woman about to be hit by a truck in the road, and just as she is about to get hit he pushes her out of the way and the truck collides with him stopping it.After his heroic feat he is congratulated by passers-by, but as they are congratulating him he looks to his right and sees he has accidentally pushed the woman into a woodchipper and the dog she was holding the lead of up is slowly getting pulled up into the machine as well. Trey offers to become his sidekick, but Rick resigns. His Uncle and he have a brief fight, which reminds Rick when he was younger and rich with his parents who die in a spoof of Batman Begins. His father urges him to invest of all his money in, not Google, but Enron.Rick later watches the girl of his dreams, Jill, who leaves with Lance in his car. Rick wants a car, and he sets out to get money from the bank. He fails though, with no credit or payment.After his uncle is quickly injured, Rick is met by Xavier (Tracy Morgan) at his school for mutants ala X-Men. Rick is told to make a costume, which he does (and later improves), and he becomes known as the Dragonfly. He quickly becomes a sensation, until his fight with the Hourglass, who ends up cutting him with little hourglass blades. The Hourglass then escapes.Jill is then seen walking in an alleyway and is attacked by thugs, but the Dragonfly saves her. The two then try to kiss, but encounter difficulties as Dragonfly is hanging upside down. They eventually kiss for the first time, and Jill thanks him.The scene then goes to a Thanksgiving dinner at Rick's house. During Thanksgiving Landers visits the family (everyone is unaware he is Hourglass). He nearly catches Rick dressed as the Dragonfly, but later manages to figure out his secret identity.Just as Rick and Jill are about to fall in love, the Hourglass comes in and murders Aunt Lucille. After a comical funeral, Rick decides to throw in the towel as a superhero.Trey and Uncle Albert find Rick after the funeral", "pos": "With only four days until the bar exam, an utterly unprepared law intern, Rick Robinson (Ben Gourley), is given a rare opportunity to score points with his boss, Maxwell McAllister (Rutger Hauer) and without thinking, commits to a favor he cannot afford. Rick soon finds himself stuck in a grueling cross country road trip driving a rundown U-Haul truck carrying all his boss's worldly possessions. To make matters worse, he is left in charge of Mr. McAllister's bratty Hollywood-bound niece Michelle (Mila Kunis) and her out-of-control pet pig. The trip from Miami to Los Angeles meets several snags. The truck breaks down on a backwoods road in the deep South, and Rick's clothes are burned by the hillbilly family providing them refuge for the night. Later, another breakdown results in Rick being knocked unconscious. He is rescued by a peculiar hitchhiker called Orlie (Jon Heder), who finds a motel room for him and Michelle. Orlie asks to accompany Rick and Michelle, and is accepted, as Rick believes he owes him a favor for his rescue. Michelle takes a shine to Orlie, and they proceed to have fun at Rick's expense. After Orlie forces Rick into an unusual encounter in a fast food restaurant lavatory, Rick decides to leave him behind. He and Michelle grow closer to one another, following a stop at a Texas beach. Rick permits Michelle to drive, despite the insurance liability, due to fatigue. He wakes to find Michelle has taken them to Wichita, Kansas and Rick's home. Consequently, Rick is forced into a painful confrontation with his mentally ill father, an experience for which Michelle apologizes. They grow even closer as Michelle relates her life growing up. The pair travel to Colorado, where the truck runs out of gas. A semi in which Orlie is traveling as a passenger comes to their aid. Following a stop in a small town, the truck (and Michelle's pig) is stolen by men working for local crime boss \"The Lady\" (Billy Drago). The Lady forces Rick and Orlie to fight in a cage match before he returns the truck, impressed by the show they put on. Crossing into Utah, Orlie spots a landscape that matches a drawing in his notebook. He believes that he has switched bodies as some past moment when he was near death, and believes that the person now occupying his body will arrive here. A switch can then take place. Orlie leaves Rick and Michelle, telling them to keep going. As the window for Rick to safely arrive back in Miami for the bar exam narrows, he rejects Michelle's assertions that there is something special between them. Rick drives straight to Los Angeles, arriving in Malibu where Mr. McAllister is waiting for them at his beachside property. He states that Rick has arrived late, but does not appear overtly concerned. Realizing he must hurry to fly back to Miami, Rick rushes to the taxi McAllister has arranged for him, leaving Michelle asleep in the truck. At the airport security checkpoint, Rick realizes he is making a terrible mistake as he observes the Polaroid photos Michelle has snapped throughout their trip. Knowing he is meant to be with Michelle, he scrambles out of the airport and returns to Malibu. Finding Mr. McAllister, Rick confesses his feelings for Michelle. McAllister, having heard similar sentiments from Michelle regarding Rick, thanks him for returning and asks him to take care of her. McAllister adds that his law firm will be opening a Los Angeles branch. The movie ends as Rick reunites with Michelle on the beach, and a man approaches Orlie back in Utah.", "neg": "Lindsay (Ashley C. Williams) and Jenny (Ashlynn Yennie), two American tourists in Germany, are drugged and involuntarily detained by crazed surgeon Dr. Josef Heiter (Dieter Laser) when they seek help at his house after they get a flat tire. The women awake in a makeshift medical ward. They witness Heiter kill a kidnapped truck driver after Heiter informs him he is \"not a match\". Heiter secures a new male captive, Japanese tourist Katsuro (Akihiro Kitamura). The doctor explains that he is a world-renowned expert at separating Siamese twins, but dreams of making new creatures by sewing people together. He describes in detail how he will surgically connect his three victims mouth-to-anus, so that they share a single digestive system. After Lindsay tries to escape and fails, Heiter explains that he had previously experimented with creating what he called a \"three-dog\", also joined mouth-to-anus. However, the three-dog died shortly after surgery. Heiter tells Lindsay that one dog tried to escape and that dog became the middle, thus this caused the most pain to the dog and as punishment for her escape attempt, she will become the middle part of his centipede. Heiter performs the surgery, placing Katsuro at the front, Lindsay in the middle and Jenny at the rear. He removes the front teeth of both women and mutilates the buttocks of both Katsuro and Lindsay in order to provide easier access to the rectums, to which he hideously stitches and grafts their mouths. During his procedure, he severs the ligaments within his victims' knees to prevent leg extension, forcing his victims to crawl. He then connects his victims together in a straight line with their mouths surgically attached to the anus of the victim in front of them. Once the operation is complete, Heiter attempts to train his centipede as a pet, often belittling Katsuro with racist insults and beating him with a crop when he becomes rebellious. When Katsuro defecates, Lindsay is forced to swallow his excrement while the doctor watches in delight. However, he eventually becomes irritated after being kept awake by the constant screaming of Katsuro (who, as the front part of the centipede, has his mouth free and is still able to speak) and the realization that Jenny is dying from septicemia. When two detectives, Kranz (Andreas Leupold) and Voller (Peter Blankenstein), visit the house to investigate the disappearance of tourists, Heiter comes up with an idea to add them as replacements for Jenny in a new creation; a four-segment centipede. He offers the two detectives water spiked with sedatives in hopes of knocking the two unconscious. After being given the water, the detectives become suspicious and obtain a search warrant for his home. While the detectives leave Heiter's home, the victims attempt to escape. Katsuro attacks Heiter in the process. Their attempt to escape ultimately fails. Katsuro confesses to the doctor that he deserves his fate because he had treated his own family poorly, then commits suicide by slitting his throat with a glass shard. Upon returning to Heiter's home, the detectives forcefully conduct separate searches as an injured Heiter hides near his swimming pool. Kranz finds the ward along with Heiter's victims. Voller begins to feel ill from the earlier drugging, and Heiter stabs him with the scalpel pulled from his leg during Katsuro's attack. Upon finding Voller dead, Kranz is shot by Heiter with Voller's sidearm. Kranz responds by shooting Heiter in the head before dying. Back in the house, Jenny and Lindsay hold hands as Jenny dies. Lindsay sobs as she is left alone in the house, trapped between her deceased fellow captives. Her fate is left unknown. The film ends with the sounds of her sobbing while the camera pans to the roof of the house.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}123{"query": "Salt Flat Utah, 1873. Stubby Preston (Fabio Testi) a card-shard and gambling trickster, arrives in the small Wild West town to practice his art at the local casino. However, the town sheriff (Donald O'Brien) recognizes him climbing out of the stagecoach and within minutes, he is in a jail cell for the night and his marked cards are burned. Stubby's cell-mates are Emmanuelle 'Bunny' O'Neill (Lynne Frederick) a young prostitute; Bud (Harry Baird), a mentally disturbed black man who is obsessed with the dead; and Clem (Michael J. Pollard), the town drunkard. During the night, a masked posse of men wreck havoc throughout the settlement. Fearing for their safety as the massacre progresses, the prisoners demand to be realeased, but the sheriff refuses. The following morning, the sheriff, amused by Stubby's ways, allows them to leave town, pointing them to an abandoned wagon as their means of transportation. The sheriff also tells them that the massacre was all his idea to reclaim the town from lawlessness.The four released convicts decide to travel together, and Stubby takes a liking to Bunny. As they travel, aiming to his the next big town over 200 miles away, a friendship develops between the four reprobates. During their first stop for the night, Bunny reveals that she's eight months pregnant, having gotten knocked up by a client in Salt Flat and has been hiding it with oversized dresses. The following day, the four have an encounter with a group of Christian missionaries from Switzerland where Stubby has Bunny pose as his wife, who's happy about the charade.Afterwards, the four's idyll is interrupted by appearance of a Mexican sharpshooter called Chaco (Tomas Milian). Despite initial suspicious, he is welcomed into the group. Chaco displays his shooting skills by shooting rabbits and ducks for their meal for the night. But he shows a sinister side when the group is attacked by three posse members from Salt Flat, and Chaco gleefully shoots all three of them, and sadistically tortures the one surviving posse member. That evening, Chaco persuades the group to take peyote with him. Stubby, secretly spits out the hallucinogenic cactus, suspicious alerted, but the rest of the party accepts. Chaco then amuses himself with Clem, humiliating the drug-addled alcoholic by ordering that he crawl and bark like a dog for some liquor. When Stubby attempts to make a run for it, Chaco subdues him and ties up the four travelers at gunpoint. As day breaks, Chaco rapes Bunny despite seeing her condition. Stubby swears to kill Chaco one day if he survives. The evil bandit then rides off on the wagon with all their gear, leaving them tied up in the desert, except for Clem who he shoots in the leg. Clem frees the others and they continue their trek on foot. As Clems wound worsens, Stubby is forced to remove the bullet and he and Bud carry him on a makeshift stretcher. Later, the group comes upon the aftermath of another attack by Chaco and two henchmen. The Christian wagoners, children and all, have all been slaughtered.The group's journey continues. Eventually the four friends see buildings ahead. The arrive in a small town in the pouring rain, but discover that it's a ghost town. The following morning is bright and sunny. Bud is ecastic when he discovers a graveyard full of friends to talk to. That evening, Clem gets more sicker from the infection of his wound. But he makes dying request that Stubby and Bunny to get married. The couple profess their love for one another and they kiss for the first time. The next morning, the couple decide to leave the ghost town. Bud elects to stay behind having learned to hunt animals for food. But Stubby and Bunny discover Clems mutilated dead body and learn that Bud has taken a liking to cannibalism as well. Stubby and Bunny leave Bud and his 'city of the dead' and head on out.A little later, the couple run into another one of Stubby's old acquaintances, the pseudo-Reverend Sullivan (Adolfo Lastretti). Stopping for", "pos": "September 1939. Mrs. Kay Miniver (Greer Garson) and her family live a comfortable life at a house called 'Starlings' in Belham, a fictional village outside London, England. The house has a large garden, with a private landing stage on the River Thames at which is moored a motorboat belonging to her devoted husband Clem (Walter Pidgeon), a successful architect. They have three children: the youngsters Toby and Judy (Christopher Severn and Clare Sandars) and an older son Vin (Richard Ney) at university. They have live-in staff: Gladys the housemaid (Brenda Forbes) and Ada the cook (Marie De Becker).As World War II looms, Vin comes down from university and meets Carol Beldon (Teresa Wright), granddaughter of Lady Beldon (Dame May Whitty) from nearby Beldon Hall. Despite initial disagreements (mainly contrasting Vin's idealistic attitude to class differences with Carol's practical altruism) they fall in love. Vin proposes to Carol in front of his family at home after his younger brother prods him to give a less romantic but more honest proposal.Several months later, as the war comes closer to home with the bombing of Great Brittan, Vin feels he must \"do his bit\" and enlists in the Royal Air Force, qualifying as a fighter pilot. He is posted to a base near to his parents' home and is able to signal his safe return from operations to his parents by cutting his engines briefly as he flies over the house. Together with other boat owners, Clem volunteers to take his motorboat to assist in the May-June 1940 Dunkirk evacuation.Early one morning, Kay unable to sleep as Clem is still away, wanders down to the landing stage. She is startled to discover a wounded German pilot (Helmut Dantine) hiding in her garden and he holds her at gunpoint. Demanding food and a coat, the pilot maniacally asserts that the Third Reich will mercilessly overcome its enemies. She feeds him, calmly disarms him and then calls the police. Soon after, Clem returns home, exhausted, from Dunkirk.Lady Beldon visits Kay to try and convince her to talk Vin out of marrying Carol on account of her granddaughter's comparative youth. Lady Beldon is unsuccessful and admits defeat when Kay reminds her that she, too, was young when she married her late husband. Lady Beldon concedes defeat and realises that she would be foolish to try and stop the marriage. Vin and Carol are married; Carol has now also become Mrs Miniver, and they return from their honeymoon in Scotland. A key theme is that she knows he is likely to be killed in action, but the short love will fill her life. Later, Kay and her family take refuge in their Anderson shelter in the garden during an air raid, and attempt to keep their minds off the frightening bombing by reading Alice's Adventures in Wonderland, which Clem refers to as a \"lovely story\" as they barely survive a bomb destroys parts of the house. They take the damage with nonchalance.At the annual village flower show, Lady Beldon silently disregards the judges' decision that her rose is the winner, instead announcing the entry of the local stationmaster, Mr. Ballard (Henry Travers), named the \"Mrs. Miniver\" rose, as the winner, with her own rose taking second prize. As air raid sirens sound and the villagers take refuge in the cellars of Beldon Hall, Kay and Carol drive Vin to join his squadron. On their journey home they witness fighter planes in a 'dogfight'. For safety, Kay stops the car and they see the German plane crash. Kay realises Carol has been wounded by shots from the plane and takes her back to 'Starlings'. She dies a few minutes after they reach home. Kay is devastated. When Vin returns from battle, he already knows the terrible news. Unexpectedly he is the survivor, and she the one who gives her life for England.The villagers assemble at the badly damaged church where their vicar (Henry Wilcoxon) affirms their determination in a powerful sermon:\"We in this quiet corner of England have suffered the loss of friends very dear to us, some", "neg": "Upon receiving a divorce in Reno, Helen Trent (Claire Trevor) plans to return to San Francisco and goes back to the boarding house where she is renting a room from Mrs. Kraft (Esther Howard) but discovers two dead bodies in the kitchen. Sam Wild (Lawrence Tierney) is the murderer and has committed the crime out of a jealous drive - one of the bodies was his girl friend Laury Palmer (Isabel Jewell) and the other a new man she was dating. Helen grabs her bags and heads for the train and coincidentally Sam does too pushed by his close friend Marty Waterman (Elisha Cook, Jr.) who stays in Reno to get details on the murder and agrees to meet Sam later. Coincidentally Sam and Helen meet on the train and are attracted to each other in part because in a casino earlier they had flirted across the Craps table. In San Francisco Helen parts with Sam but he crashes in on her and her fiancee Fred Grover (Phillip Terry) and her half-sister Georgia Staples (Audrey Long) who has inherited a large newspaper company. Sam sees a good thing in Grace and successfully seduces her into marrying him partly for the power her money can bring him but also to sustain the attraction he has for Helen. Mrs. Kraft hires seedy private detective Matthew Arnett (Walter Slezak) to find out who killed her good friend Laury and the shamus arrives on the wedding day of Sam and Georgia. Helen manages to leak some information to Arnett but Sam discovers this as well and gets his buddy Marty to track down Mrs. Kraft to put an end to things. But this plan goes awry when Marty stops to try to get more information from Helen and Sam perceives it as a play for the woman. Sam reacts in a jealous pique and Helen realizes that he must be stopped and calls Arnett to bring the police with the information he has gathered from his investigation. Sam discovers Helen's communication with Arnett and pulls his gun just as the police arrive resulting in a climactic shootout.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}124{"query": "Almost all earthquakes occur at plate boundaries. All types of plate boundaries have earthquakes. Convection within the Earth causes the plates to move. As the plates move, stresses build. When the stresses build too much, the rocks break. The break releases the energy that was stored in the rocks. The sudden release of energy creates an earthquake. During an earthquake the rocks usually move several centimeters or rarely as much as a few meters. Elastic rebound theory describes how earthquakes occur (Figure 7.21). Where an earthquake takes place is described by its focus and epicenter. The point where the rock ruptures is the earthquakes focus. The focus is below the Earths surface. A shallow earthquake has a focus less than 70 kilometers (45 miles). An intermediate-focus earthquake has a focus between 70 and 300 kilometers (45 to 200 miles). A deep-focus earthquake is greater than 300 kilometers (200 miles). About 75% of earthquakes have a focus in the top 10 to 15 kilometers (6 to 9 miles) of the crust. Shallow earthquakes cause the most damage. This is because the focus is near the Earths surface, where people live. The area just above the focus, on the land surface, is the earthquakes epicenter (Figure 7.22). The towns or cities near the epicenter will be strongly affected by the earthquake. Nearly 95% of all earthquakes take place along one of the three types of plate boundaries. As you learned in the Plate Tectonics chapter, scientists use the location of earthquakes to draw plate boundaries. The region around the Pacific Ocean is called the Pacific Ring of Fire. This is due to the volcanoes that line the region. The area also has the most earthquakes. About 80% of all earthquakes strike this area. The Pacific Ring of Fire is caused by the convergent and transform plate boundaries that line the Pacific Ocean basin. About 15% of all earthquakes take place in the Mediterranean-Asiatic belt. The convergent plate boundaries in the region are shrinking the Mediterranean Sea. The convergence is also causing the Himalayas to grow. The remaining 5% of earthquakes are scattered around the other plate boundaries. A few earthquakes take place in the middle of a plate, away from plate boundaries. Transform plate boundaries produce enormous and deadly earthquakes. These quakes at transform faults have shallow focus. This is because the plates slide past each other without moving up or down. The largest earthquake on the San Andreas Fault occurred in 1906 in San Francisco. Other significant earthquakes in California include the 1989 Loma Prieta earthquake near Santa Cruz (Figure 7.23) and the 1994 Northridge earthquake near Los Angeles. There are many other faults spreading off the San Andreas, which produce around 10,000 earthquakes a year (Figure Convergent plate boundaries also produce strong, deadly earthquakes. Earthquakes mark the motions of colliding plates and the locations where plates plunge into the mantle. These earthquakes can be shallow, intermediate or deep focus. The Philippine plate and the Pacific plate subduct beneath Japan, creating as many as 1,500 earthquakes every year. In March 2011, the 9.0 magnitude Tohoku earthquake struck off of northeastern Japan. Damage from the quake was severe. More severe was the damage from the tsunami generated by the quake (Figure 7.25). In all, 25,000 people were known dead or missing. The Cascades Volcanoes line the Pacific Northwest of the United States. Here, the Juan de Fuca plate subducts beneath the North American plate. The Cascades volcanoes are active and include Mount Saint Helens. Major earthquakes occur here approximately every 300 to 600 years. The last was in 1700. Its magnitude was between 8.7 and 9.2. It has now been more than 300 years since that earthquake. The next massive earthquake could strike the Pacific Northwest at any time. The collision of two continents also creates massive earthquakes. Many earthquakes happen in the region in and around the Himalayan Mountains. The 2001 Gujarat, India earthquake is responsible for about 20,000 deaths, with many more people injured or made homeless. Earthquakes also occur at divergent plate boundaries. At mid-ocean ridges, these earthquakes tend to be small and shallow focus because the", "pos": "An earthquake is sudden ground movement caused by the sudden release of energy stored in rocks. Earthquakes happen when so much stress builds up in the rocks that the rocks rupture. The energy is transmitted by seismic waves. Earthquakes can be so small they go completely unnoticed, or so large that it can take years for a region to recover. The description of how earthquakes occur is called elastic rebound theory (Figure 1.1). Elastic rebound theory. Stresses build on both sides of a fault, causing the rocks to deform plastically (Time 2). When the stresses become too great, the rocks break and end up in a different location (Time 3). This releases the built up energy and creates an earthquake. Click image to the left or use the URL below. URL: In an earthquake, the initial point where the rocks rupture in the crust is called the focus. The epicenter is the point on the land surface that is directly above the focus (Figure 1.2). In the vertical cross section of crust, there are two features labeled - the focus and the epicenter, which is directly above the focus. Click image to the left or use the URL below. URL:", "neg": "Earthquake magnitude affects how much damage is done in an earthquake. A larger earthquake damages more buildings and kills more people than a smaller earthquake. But thats not the only factor that determines earthquake damage. The location of an earthquake relative to a large city is important. More damage is done if the ground shakes for a long time. The amount of damage also depends on the geology of the region. Strong, solid bedrock shakes less than soft or wet soils. Wet soils liquefy during an earthquake and become like quicksand. Soil on a hillside that is shaken loose can become a landslide. Hazard maps help city planners choose the best locations for buildings (Figure 7.38). For example, when faced with two possible locations for a new hospital, planners must build on bedrock rather than silt and clay. The 1985 Mexico City earthquake measured magnitude 8.1. The earthquake killed at least 9,000 people, injured 30,000 more, and left 100,000 people homeless. It destroyed 416 buildings, and seriously damaged 3,000 other buildings. The intense destruction was due to the soft ground the city is built on. Silt and clay fill a basin made of solid rock. In an earthquake, seismic waves bounce back-and-forth off the sides and bottom of the rock basin. This amplifies the shaking. The wet clay converts to quicksand (Figure 7.39). Many buildings were not anchored to bedrock. They settled into the muck. This caused enormous damage. Water, sewer, and electrical systems were destroyed, resulting in fires. Acapulco was much closer to the epicenter, but since the city is built on bedrock it suffered little damage. The amount of damage depends on the amount of development in the region. The 1964 Great Alaska Earthquake, near Anchorage, was the largest earthquake ever recorded in North America. The gigantic quake had a magnitude of 9.2. The earthquake lasted for several minutes and the ground slipped up to 11.5 meters (38 feet). An area of 100,000 square miles (250,000 square km) was affected. The ground liquefied, causing landslides (Figure 7.40). The earthquake occurred at a subduction zone, and large tsunami up to 70 meters (20 feet) high were created. Despite the intensity of the earthquake, only 131 people died. Most deaths were due to the tsunami. Property damage was just over $300 million ($1.8 billion in 2007 U.S. dollars). The reason there was such a small amount of damage is that very few people lived in the area (Alaska had only been a state for five years!). A similar earthquake today would affect many more people. Buildings must be specially built to withstand earthquakes. Skyscrapers and other large structures built on soft ground must be anchored to bedrock. Sometimes that bedrock is hundreds of meters below the ground surface! Building materials need to be both strong and flexible. Small structures, like houses, should bend and sway. Wood and steel bend. Brick, stone, and adobe are brittle and will break. Larger buildings must sway, but not so much that they touch nearby buildings. Counterweights and diagonal steel beams can hold down sway. Buildings need strong, flexible connections where the walls meet the foundation. Earthquake-safe buildings are well connected (Figure Steel or wood can be added to older buildings to reinforce a buildings structure and its connections (Figure 7.42). Elevated freeways and bridges can also be reinforced so that they do not collapse. Important structures must be designed to survive intact. One of the biggest problems caused by earthquakes is fire. Fires start because earthquakes rupture gas and electrical lines. Water mains may break. This makes it difficult to fight the fires. The shapes of pipes can make a big difference. Straight pipes will break in a quake. Zigzag pipes bend and flex when the ground shakes. In San Francisco, water and gas pipelines are separated by valves. Areas can be isolated if one segment breaks. Strong, sturdy structures are expensive to build. Communities must decide how safe to make their buildings. They must weigh how great the hazard is, what different building strategies will cost, and how much risk they are", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}125{"query": "In an endothermic reaction, it takes more energy to break bonds in the reactants than is released when new bonds form in the products. The word \"endothermic\" literally means \"taking in heat.\" A constant input of energy, often in the form of heat, is needed in an endothermic reaction. Not enough energy is released when products form to break more bonds in the reactants. Additional energy is needed to keep the reaction going. The general equation for an endothermic reaction is: Reactants + Energy ! Products In many endothermic reactions, heat is absorbed from the surroundings. As a result, the temperature drops. The drop in temperature may be great enough to cause liquid products to freeze. Thats what happens in the endothermic reaction at this URL: One of the most important endothermic reactions is photosynthesis. In this reaction, plants synthesize glucose (C6 H12 O6 ) from carbon dioxide (CO2 ) and water (H2 O). They also release oxygen (O2 ). The energy for photo- synthesis comes from light (see Figure 8.12). Without light energy, photosynthesis cannot occur. The chemical equation for photosynthesis is: 6CO2 + 6H2 O ! C6 H12 O6 + 6O2 In an exothermic reaction, it takes less energy to break bonds in the reactants than is released when new bonds form in the products. The word \"exothermic\" literally means \"turning out heat.\" Energy, often in the form of heat, is released as an exothermic reaction occurs. The general equation for an exothermic reaction is: Reactants ! Products + Energy If the energy is released as heat, an exothermic reaction results in a rise in temperature. Thats what happens in the exothermic reaction at the URL below. Combustion reactions are examples of exothermic reactions. When substances burn, they usually give off energy as heat and light. Look at the big bonfire in Figure 8.13. You can see the light energy it is giving off. If you were standing near the fire, you would also feel its heat. Whether a reaction absorbs energy or releases energy, there is no overall change in the amount of energy. Energy cannot be created or destroyed. This is the law of conservation of energy. Energy can change form for example, from electricity to light but the same amount of energy always remains. If energy cannot be destroyed, what happens to the energy that is absorbed in an endothermic reaction? The energy is stored in the chemical bonds of the products. This form of energy is called chemical energy. In an endothermic reaction, the products have more stored chemical energy than the reactants. In an exothermic reaction, the opposite is true. The products have less stored chemical energy than the reactants. The excess energy in the reactants is released to the surroundings when the reaction occurs. The graphs in Figure 8.14 show the chemical energy of reactants and products in each type of reaction. All chemical reactions, even exothermic reactions, need a certain amount of energy to get started. This energy is called activation energy. For example, activation energy is needed to start a car. Turning the key causes a spark that activates the burning of gasoline in the engine. The combustion of gas wont occur without the spark of energy to begin the reaction. Why is activation energy needed? A reaction wont occur unless atoms or molecules of reactants come together. This happens only if the particles are moving, and movement takes energy. Often, reactants have to overcome forces that push them apart. This takes energy as well. Still more energy is needed to start breaking bonds in reactants. The graphs in Figure 8.15 show the changes in energy in endothermic and exothermic reactions. Both reactions need the same amount of activation energy in order to begin. You have probably used activation energy to start a chemical reaction. For example, if youve ever used a match to light a campfire, then you provided the activation energy needed to start a combustion reaction. Combustion is exothermic. Once a fire starts to burn, it releases enough energy to activate the next reaction, and the next, and so on. However, wood will not burst", "pos": "The water droplets of fog form from water vapor in the air. Fog disappears when the water droplets change back to water vapor. These changes are examples of changes of state. A change of state occurs whenever matter changes from one state to another. Common states of matter on Earth are solid, liquid, and gas. Matter may change back and forth between any two of these states. Changes of state are physical changes in matter. They are reversible changes that do not change matters chemical makeup or chemical properties. For example, when fog changes to water vapor, it is still water and can change back to liquid water again. Several processes are involved in common changes of state. They include melting, freezing, sublimation, deposition, condensation, and evaporation. The Figure 1.1 shows how matter changes in each of these processes. Q: Which two processes result in matter changing to the solid state? A: The processes are deposition, in which matter changes from a gas to a solid, and freezing, in which matter changes from a liquid to a solid. Suppose that you leave some squares of chocolate candy in the hot sun. A couple of hours later, you notice that the chocolate has turned into a puddle like the one pictured in the Figure 1.2. Q: What happened to the chocolate? A: The chocolate melted. It changed from a solid to a liquid. In order for solid chocolate to melt and change to a liquid, the particles of chocolate must gain energy. The chocolate pictured in the Figure 1.2 gained energy from sunlight. Energy is the ability to cause changes in matter, and it is always involved in changes of state. When matter changes from one state to another, it either absorbs energyas when chocolate meltsor loses energy. For example, if you were to place the melted chocolate in a refrigerator, it would lose energy to the cold air inside the refrigerator. As a result, the liquid chocolate would change to a solid Q: Why is energy always involved in changes of state? A: The energy of particles of matter determines the matters state. Particles of a gas have more energy than particles of a liquid, and particles of a liquid have more energy than particles of a solid. Therefore, in order for matter to change from a solid to a liquid or from a liquid to a gas, particles of matter must absorb energy. In order for matter to change from a gas to a liquid or from a liquid to a solid, particles of matter must lose energy.", "neg": "LHCII, the most abundant membrane protein on earth, is the major light-harvesting complex of plants. It is generally accepted that LHCII is associated with Photosystem II and only as a short-term response to overexcitation of PSII a subset moves to Photosystem I, triggered by its phosphorylation (state1 to state2 transition). However, here we show that in most natural light conditions LHCII serves as an antenna of both Photosystem I and Photosystem II and it is quantitatively demonstrated that this is required to achieve excitation balance between the two photosystems. This allows for acclimation to different light intensities simply by regulating the expression of LHCII genes only. It is demonstrated that indeed the amount of LHCII that is bound to both photosystems decreases when growth light intensity increases and vice versa. Finally, time-resolved fluorescence measurements on the photosynthetic thylakoid membranes show that LHCII is even a more efficient light harvester when associated with Photosystem I than with Photosystem II.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}126{"query": "Richard Packard is an American physicist, a professor at the University of California, Berkeley, known for having built the first quantum gyroscope with his colleagues.", "pos": "James R. Redmond is Emeritus Professor of Zoology in the Iowa State University department of Ecology, Evolution and Organismal Biology.", "neg": "The first astronomer to record the Butterfly Cluster's existence was Giovanni Battista Hodierna in 1654.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}127{"query": "NeXTSTEP (also stylized as NeXTstep, NeXTStep, and NEXTSTEP) is a combination of several parts: a Unix operating system based on the Mach kernel, plus source code from BSD Display PostScript and a proprietary windowing engine the Objective-C language and runtime an object-oriented (OO) application layer, including several ''kits'' development tools for the OO layers NeXTSTEP is notable for having been a preeminent implementation of the latter three items.", "pos": "Nevow (pronounced like the French nouveau) is a Python web application framework originally developed by the company Divmod.", "neg": "The All-Russia People's Front (Russian: ), known by its Russian initialism ONF, is a movement in Russia started in 2011 by then-Prime Minister of Russia Vladimir Putin to provide United Russia with ''new ideas, new suggestions and new faces''.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}128{"query": "Set on the campus of a small New England college, the film focuses on the volatile relationship of a middle-aged couple: associate history professor George (Richard Burton) and his hard-drinking wife Martha (Elizabeth Taylor), the daughter of the college president.It's 2:00 a.m. on a Sunday morning, and they have returned from one of her father's gatherings. Martha announces she has invited a young couple--Nick (George Segal), a young, good-looking, newly appointed instructor, and his mousey wife Honey (Sandy Dennis)--to join them for late-night drinks. George is disturbed because she did so without consulting him first, prompting Martha to launch into the first of many loud and lengthy tirades during which she taunts and criticizes him. Knowing his wife is drunk and quite lewd, he asks her to behave herself when they arrive, and when the doorbell rings, he warns her to refrain from mentioning their child to their company.Overhearing Martha's crude retort as the door opens, Nick and Honey immediately feel ill at ease and quickly find themselves caught in the middle of a verbal war zone when their efforts to engage in small talk set off a volley of insults between their hosts. Martha begins to flirt lewdly with Nick while his meek wife tries to pretend she is unaware of what is happening.While Martha is showing Honey where the bathroom is, George tests Nick's verbal sparring skills, but the young man is no match for his host. Realizing he and his wife are becoming embroiled in the middle of marital warfare, he suggests they depart, but George cajoles him into staying.Upon returning to the living room alone, Honey innocently mentions to George she was unaware he and Martha had a son on the verge of celebrating his 16th birthday. Martha reappears in a new outfit--form-fitting slacks and a revealing blouse--and when her husband makes a snide remark about the ensemble, she begins to demean his abilities as a teacher, then escalates her seduction of Nick, complimenting him on the body he developed as both a quarterback and an intercollegiate state boxing champion while criticizing George's paunch. She informs their guests about a past incident when George refused to engage in a friendly outdoor boxing match with his father-in-law and Martha put on a pair of gloves and punched him in the jaw, knocking him into the bushes. As she relates the story, George aims a shotgun at the back of her head, causing Honey to scream. He pulls the trigger, which releases an umbrella, while he tells his wife she's dead.Honey again raises the subject of George and Martha's son, prompting the couple to engage in a conversation Martha quickly tries to end without success. To counterattack George's relentless comments about the boy, she tells their guests her husband is unsure the child is his own, although he most assuredly is. They argue about the color of the boy's eyes until George threatens to expose the truth about the boy. Furious, Martha accuses him of being a failure whose youthful, idealistic plans for the future slowly deteriorated as he came to realize he wasn't aggressive enough to follow in his father-in-law's footsteps, leaving her stuck with a flop. George cuts the diatribe short by spinning Honey around and mockingly singing, \"Who's afraid of Virginia Woolf?\", a joke the shrewed Martha had made herself during the party earlier that evening.Inebriated and on the verge of throwing up from George's spinning, Honey rushes from the room. Martha goes to the kitchen to make coffee, and George and Nick go outside. The younger man confesses he was attracted to Honey more for her family's money than passion, and married her only because she mistakenly believed she was pregnant. George describes his own marriage as one of never-ending accommodation and adjustment, then admits he considers Nick a threat. George also tells a story about a boy he grew up with. This boy had accidentally killed his mother. Years later, George claims the boy was driving with his father. He swerved to \"miss a porcupine\" in the road,", "pos": "Harvey Shine (Dustin Hoffman) works as a jingle writer for television commercials in Manhattan, a job not in keeping with his one-time aspiration to be a jazz composer and pianist. We see him at work and he is very good at what he does. However, his boss does not seem impressed with his latest output. As Harvey departs for London to attend his daughter Susan's wedding, his boss actually suggests that he spend more time there than he had originally planned. Harvey declines, making the point that he needs to be back for an upcoming pitch to an old client. His boss insists that it is being done by other musicians, and that Harvey's latest work was his last chance to keep his job.On the plane, Harvey tries to chat up a fellow passenger, but she is having none of it. He is left sitting there with egg on his face and we come to regard him as even more of a loser.Meanwhile, we witness the mildly strained relationship between Kate Walker (Emma Thompson), a single Londoner, and her mother, whose husband left years earlier. Kate tries to reassure her mother that despite being single, she may yet find a man. Further, Kate tells her mom to quit worrying about the new Polish neighbor who has moved in next door and seems to be stacking a lot of firewood.Upon arrival at Heathrow Airport in London, Harvey encounters Kate at her job collecting statistics from passengers as they pass through the terminals. She attempts to question him about his reasons for visiting the UK. Tired and anxious to get to his hotel, Harvey brusquely dismisses her when she approaches him to ask questions.Harvey heads for the hotel to check in and discovers that he is the first one to arrive. Upon calling his daughter to double check where everyone else is when they were all supposed to be staying together, he learns that his ex-wife Jean actually rented a house to accommodate family and friends from the States and he is the only one at the hotel.After a brief nap, he showers and hurriedly dresses. On the way to the rehearsal dinner in the taxi cab, he realizes the anti-shoplifting device is still attached to the sleeve of his jacket. And to make matter worse, he has worn a white suit (thinking this was requested) while all the other men wore black. During the meal, it becomes increasingly clear Harvey is considered a mere guest and the role of father of the bride has been delegated to Jean's husband Brian. To add insult to injury, Brian stands to give the toast, and recollects the vacation they all spent in Rome, and his stepson-in-law-to-be embraces him and calls him Dad. Just before leaving back to his hotel, when Harvey tells Susan (with whom he has shared a strained relationship since his divorce) that he will be attending the ceremony but not the subsequent reception because he needs to return to the States for an important meeting, she informs him she has asked Brian to give her away.Meanwhile, Kate is set up on a blind date by a well meaning co-worker that does not go well. When she returns to the table after taking yet another call from her mother, she discovers her younger date has invited some of his younger friends to join them. Feeling unwanted and excluded from the conversation, she eventually excuses herself and goes home. As it turns out, Kate's increasingly neurotic mother seems convinced that her Polish neighbor is some kind of murderer because she sees him toting strange looking, lumpy packages into a shed in the back yard.The following morning Harvey attends Susan's wedding, but heavy traffic delays his arrival back to Heathrow, and he misses his plane. When he calls his boss Marvin in NYC to inform him he will be returning a day later than planned and that he will try to get there as soon as possible, he is told that he is fired.In his glum mood, Harvey makes his way to the airport bar and starts slugging down scotch, determined to drown his sorrows. Kate is sitting in the lounge reading", "neg": "A large group of college students are at a bonfire for the New Year's Eve celebration. All of the pledges are wearing beanies, and one nerd-ish pledge named Kenny (Derek McKinnon) is sent by the fraternity president Doc (Hart Bochner) and his friends up to a room in the frat house where a sorority sister named Alana (Jamie Lee Curtis) is waiting in the doorway. Alana walks inside the bedroom and stands behind the canopy in the dark room. Kenny undressed, sits in bed, and realizes that he is sitting beside a bloated and rotting corpse. Kenny screams in terror and he stands up on the bed and is caught up in the canopy. Alana seems repulsed as Doc and a group of other students rush in and laugh at Kenny.Three years later. A large group of college kids are exiting a bus at a train station. They have a toast celebrating four great years at college as they prepare to board a charted old train for a New Year's Eve costume party. Carne (Ben Johnson), the lead conductor, has the students board the train while he organizes the route with the dispatcher. Carne helps a magician (David Copperfield) and his assistant carry their luggage on board, as a three-person band board the train for the excursion.Nearby, Ed (Howard Busgang) a prankster student and one of the ones involved in the prank against Kenny, walks around with a sword through his stomach. The other students laugh and think its another one of his practical jokes, but he falls down after the people walk away and board the train. An unseen person takes Ed's Groucho Marx costume and rolls his dead body under the train tracks. The train leaves and the lights at the deserted station are turned off. The killer is wearing Ed's costume as he moves around the train.Meanwhile, Mitchy (Sandee Currie) another one of the students involved in the prank against Kenny, is talking to Alana who is graduating early and hopes they will keep in touch.In the back of the train, the magician is talking to his blond assistant about the rowdy college kids and complaining about having to perform his illusions in front of them.In the lounge car, Doc is celebrating with his fellow frat brothers when one of them asks about the now abolished \"hog night\" and he mentions that something bad happened. Alana enters and tells them that they \"put a kid in the hospital\" who had a nervous breakdown due to Doc's prank three years ago. Alana then goes to her boyfriend Mo, also involved in the prank against Kenny, where they retire for some alone time.A little later, Mitchy sees 'Ed' and he follows her towards the sleeping berths. He nearly grabs her when Jackson, another of the students involved in the prank against Kenny, appears. Jackson is very inebriated and he offers 'Ed' a drink. In the nearby lavatory, the killer grabs Jackson, lifts up his mask for a second to let him see his face, and slams Jackson's head into the mirror. The killer then changes out of his Groucho Marx costume and leaves the lavatory.Meanwhile, Alana becomes angry when learning that the train party was Doc's idea after Mo told her that it was his. Two of the sorority sisters, Pet and Merry, show up where Pet thinks that her boyfriend, Ed, missed the train, and Alana argues with Mo about learning that Doc had set him up again. Carne, the conductor, shows Doc and Mitchy a car trick he learned form the magician (it is only a gag), and the couple waits for the occupied bathroom. After a few minutes, they leave to find another one.Later, the magician performs his show before the students and afterwards, the rock band appears to play. Alana talks with the geekish class president (who was a pledge in the opening scene). Meanwhile, Doc asks Mo where Jackson and Ed are. Mo does not know and when he asks where did he find the magician, Doc says that he did not hire a magician for the party and wonders", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}129{"query": "Paul Stanton (Mulroney) and his wife Diane (Diane Kruger) are a couple whose daughter is dying from a rare degenerative lung condition. The only thing that can save her life is a lung transplant from an organ donor. The movie starts when the donated lung fails to arrive correctly. The movie goes back and forth between the present and the events leading up to it. In the present day, Paul goes to Juarez, Mexico to find a man called Dr. Navarro. After leaving his cell number at many local hospitals, somebody finally contacts Paul. In the past, Dr. Rubin (Arquette), who's treating their daughter (Stallard), had given them information regarding Paul's associate, Harrison (Shepard), who somehow managed to get an organ transplant for himself, possibly from the black market. Paul confronted Harrison and finally managed to get Dr. Navarro's name from him. Harrison told him that he was contacted by Navarro and he didn't know how to reach him. Back in the present day, Paul is ambushed by a couple of Navarro's guys that tell him to stay away. After an arduous search, Paul finally finds out that Dr. Navarro is actually Dr. Martinez (Perez) from a local hospital that he visited previously for his wounds. Paul confronts Martinez and asks him to find a lung donor for his daughter, who only has one week to live. Martinez agrees to help him for a $250,000 cash payment. The next day, Martinez tells Paul that he has found a matching donor for his daughter. Paul tells Diane to go to Juarez and prepare their daughter for the transplant operation. Little does Paul know that the donor is actually a live person; Martinez and his men have planned a hit-and-run accident to get the lung implant from a local street boy. Paul discovers this fact and tells Diane about it. Diane tells him that she does not want to know where the donor comes from. Paul confronts Martinez at the operating table. Martinez tells Paul to make a choice: to go ahead with the operation or disband the operation knowing that they won't be able to find another match in time to save his daughter's life. The next scene shows Paul and Diane at their daughter's funeral. Diane gives Paul an accusing look blaming him for their daughter's death. Meanwhile, elsewhere, the local boy that was supposed to be the organ donor is alive and playing soccer with his friends.", "pos": "Private investigator Patrick Kenzie (Casey Affleck) and his partner/girlfriend Angie Gennaro (Michelle Monaghan) witness a televised plea by a woman named Helene McCready (Amy Ryan) for the return of her missing daughter Amanda, who was abducted with her favorite doll \"Mirabelle\". Patrick and Angie are then hired by the child's aunt Beatrice (Amy Madigan) to find Amanda and discover that Helene and her boyfriend \"Skinny Ray\" (Sean Malone) had recently stolen money from Cheese (Edi Gathegi), a local Haitian drug lord. After Ray is murdered, Patrick and Angie join the police detectives Remy Bressant (Ed Harris) and Nick Poole (John Ashton) with investigating the case and assist in arranging the trade of money for the return of Amanda. Captain Jack Doyle (Morgan Freeman) reads Patrick a telephone transcript of the drug lord setting up an exchange for Amanda. The exchange at a nearby quarry in Quincy is botched and it is believed Amanda drowned; her doll is found in the quarry and returned to Helene. Doyle, whose own daughter was killed years before, takes responsibility for the death and goes into early retirement. Two months later, a seven year old boy is abducted in Everett and Patrick receives information that the boy was taken by a known child molester. After entering the suspect's house and finding evidence of the abducted boy, Patrick returns with Remy and Nick to rescue him. They are seen by the residents and Nick is shot. Patrick enters the house during the shootout and finds one of the residents dead. He retreats into the child molester's room, where he finds the boy's dead body; he then shoots the child molester in the back of the head in a fit of rage. Nick later dies of his wounds. Trying to alleviate Patrick's guilt over the events at the house, Remy unthinkingly confides that he once planted evidence on someone with the help of \"Skinny Ray\" whom he had initially told Patrick he didn't know. After Nick's funeral, Patrick speaks to a police officer, who tells him that Remy had been asking about the drug lord's stolen money before the drug lord knew it was missing. Patrick then questions Beatrice's husband Lionel (Titus Welliver) in a bar and pieces together that Lionel and Remy had conspired to stage a fake kidnapping in order to take the drug money for themselves and to take Amanda from her neglectful mother's care. At that point, Remy (trying to cover for his earlier mistake) enters the bar, while wearing a latex mask and holding a shotgun, and stages a robbery. He points the shotgun at Lionel's head, but the bartender shoots Remy twice in the back. Remy flees and is pursued by Patrick to the rooftop of a nearby building, where he dies. Patrick is questioned by the police about Remy's death and learns that the police never had a phone transcript like the one that Doyle had read to him prior to the botched exchange. Patrick and Angie drive to Doyle's home, where Patrick finds Amanda living with Doyle and his wife; Doyle was part of the phony kidnapping all along. Patrick threatens to call the authorities, but Doyle attempts to convince him that Amanda is better off living with them than with her mother, and that is reason enough not to get involved. Patrick leaves and discusses the choices with Angie, who says she will leave him if he calls the police, since she also believes Amanda is much better off with the Doyles. In the next scene, the police arrive, Doyle is arrested, Amanda is returned to her mother amidst heavy publicity, and Patrick and Angie break up. Patrick later visits Amanda as Helene is about to leave on a date with someone she met during the publicity over her daughter's disappearance. Helene informs Patrick that Beatrice has been forbidden to visit and is upset about her husband's arrest. Helene has no babysitter for Amanda and when asked, she tells Patrick that Helene's friend, Dottie (Jill Quigg) will watch her, even though she has yet to ask Dottie herself. Patrick volunteers to watch Amanda, who is holding her", "neg": "Ever since the death of their teenage daughter Emily, Doug (James Gandolfini) and Lois (Melissa Leo) Riley have been drifting apart. Because of her grief, Lois has become a cold and distant agoraphobic. Doug begins an affair with Vivian, a younger local waitress. However, Lois manages to maintain her appearance and the presentation of her home despite never leaving and inviting no guests aside from her sister, Harriet. She has even already had headstones put next to their daughter's for them both and made funeral plans. One morning, Doug is informed that Vivian has died, and he travels to New Orleans on a business trip to clear his head. Instead, however, he ends up in a strip club where he meets 16-year-old stripper, Mallory (Kristen Stewart). He politely turns down her offer for a private dance and refuses any sexual contact, but instead accompanies her home and makes an unusual proposition: if Mallory will allow him to stay in her run-down house long enough to straighten himself out, he will pay her $100 a day for her trouble. For Mallory, who isn't used to getting money for doing nothing, it seems like a great deal. She accepts and Doug phones home to tell Lois he won't be coming home for a while. She tells him that she knew about his affair with Vivian but before the conversation can go any further, she hangs up. As time passes, Doug and Mallory settle into an unconventional kind of domesticity, and he becomes more of a father figure for her than anything else including teaching her how to make a bed properly and taking care of her money. Meanwhile, back home, Lois realizes that she'll have to act fast in order to save her marriage, even if that means venturing outside for the first time in nearly a decade. After a couple of attempts, Lois manages to start up her car and get on the freeway heading south. One night, Doug gets a call from Mallory who is in trouble after being robbed of the money she carries around by a client. He goes to pick her up and after arguing about how stupid she's being, he makes her realise that she needs to make some changes before things get worse. The following morning, Lois arrives in town and calls Doug to let him know, who is stunned that she not only left the house but drove all the way instead of flying. He immediately goes to meet her and they embrace one another for the first time in years. On the drive back, he tells her about Mallory (whose real name is Alison) and what she does for a living, which Lois instantly disapproves of. She is shocked to learn how young and foul-mouthed Mallory is. However, like Doug, Lois quickly warms to her due to her striking similarities to Emily. Before long, Lois has also moved in to Mallory's home and the three start to form an unconventional family. Lois helps her out with female problems and takes her shopping to buy suitable underwear, making her feel like a mother again, which she enjoys dearly. But later on when Lois attempts to steer Mallory from the path of self-destruction, the young girl flees. Mallory is then later arrested an altercation with a client, and Doug and Lois rush to be by her side, but shortly after they bail her out, she runs again. In that moment, Doug and Lois realize they cannot use Mallory as a substitute for their daughter and return home to Indianapolis. A few days later, Doug receives a phone call from Mallory in Houston. She looks cleaned up and healthier, and announces her plans about moving to Las Vegas, just before boarding the bus. Doug tells her that he and Lois will always be there for her.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}130{"query": "The film depicts the construction and ultimate demolition of a metaphorical wall. Though the film's symbolism is open to interpretation, the wall itself clearly reflects a sense of isolation and alienation.Pink (Bob Geldof), the protagonist (and unreliable narrator) of the film, is a rock star, one of several reasons behind his apparent depressive and detached emotional state. He is first seen in a quiet hotel room, having trashed it. The opening music is not by Pink Floyd, but is the Vera Lynn recording of \"The Little Boy that Santa Claus Forgot\". During the following scenes, it is revealed that Pink's father, a British soldier, was killed in action during World War II during Pink's infancy. The reference is almost certainly to the death of Roger Waters' real-life father, Eric Fletcher Waters, who died in combat in Italy during Operation Shingle (the Battle of Anzio) in February 1944.The movie then flashes back to Pink as a young English boy growing up in the early 1950s. Throughout his childhood, Pink longs for a father figure after he learns his father died in the war. At school, he is humiliated by his mean and stern teacher for writing poems in class. The poems that the teacher seizes from him and reads aloud are lyrics from \"Money\" from the Pink Floyd album Dark Side of the Moon. Pink is also affected by his overprotective mother who spoils him by giving him whatever he wants.As an adult, Pink eventually gets married as his fame as a rock star grows, but he and his wife grow apart and she has an affair while Pink is on tour. When Pink learns of the affair, he compensates with expensive materialistic possessions and turns to a willing groupie (Jenny Wright), whom he brings back to his hotel room only to trash it in a fit of violence, causing her to flee the room in terror.Pink slowly begins to lose his mind to metaphorical \"worms\". He shaves off all of his body hair (an incident inspired by former bandmate Syd Barrett, who appeared at a 1975 recording session of Wish You Were Here, having shaved his eyebrows and body hair) and, while watching The Dam Busters on television, morphs into his neo-Nazi alter-ego. Pink's manager (Bob Hoskins), along with the hotel manager (Michael Ensign) and some paramedics, break into the hotel room and discover Pink. They take him away into a waiting limousine outside the hotel and inject him with drugs to enable him to perform.The drugs cause Pink to hallucinate and he fantasises that he is a neo-Nazi dictator, his concert is a rally. His followers proceed to attack ethnic minorities and rape the white girlfriend of a black man. Later, Pink holds a rally in suburban London, singing \"Waiting for the Worms\". The scene is inter-cut by images of animated marching hammers that goose-step across ruins.Pink screams \"Stop!\" and takes refuge in a bathroom stall at the concert venue, reciting poems which would later be used as lyrics on Pink Floyd's \"Your Possible Pasts\" from The Final Cut album and \"5:11 AM (The Moment Of Clarity)\" from Roger Waters' The Pros and Cons of Hitch Hiking.In a climatic animated sequence, Pink puts himself on trial. He is depicted as a small, pink rag doll that rarely moves. The judge is a giant pair of buttocks, with two backward facing legs, an anus for a mouth and a scrotum for a chin. The lawyer is a tall, menacing, vulturelike man and the schoolmaster is an abusive, hateful marionette. After hearing from the parties and witnesses (Pink's wife and mother), the judge orders the wall to be torn down. The wall explodes and shows a montage of events from the entire film.The film concludes with three children cleaning up a pile of debris after an earlier riot. It is unknown whatever has happened to Pink, leaving the viewer to decide.", "pos": "The film opens with a man, Alderson (Julian Richings), waking up in a cube-shaped room with glowing, computer circuit-like walls and six doors, one at the center of each wall, ceiling and floor. After recovering from his confusion, he opens two of the doors and looks into them to find rooms that differ to the one he is in only by color. He then opens and goes through a third door. He looks around and then takes a step, but is suddenly cut into large cubes. He falls apart and the rack of crosshatched wires which diced him moves into view. It folds up and retracts.Later, in another room, several people find each other: Quentin (Maurice Dean Wint), Worth (David Hewlett), Holloway (Nicky Guadagni), Rennes (Wayne Robson), and Leaven (Nicole de Boer). None of them know where they are, how they got there, or why they are there. Quentin, however, knows that there are traps, as he had looked into a room and nearly got his head cut off. The five decide to stay together and look for the way out. Rennes takes the lead. He exemplifies how to test for traps by tossing a boot into the rooms while holding onto the laces, to trigger potential traps, figuring that the trapped room contains motion detectors. Holloway speculates on several possible creators of the Cube, being aliens or the government his main ptions. Rennes remarks that staying still will not solve anything, and says that they should move in a straight line until they get to the end. The others agree, and they begin moving through the rooms.While moving, they discover a series of different numbers on the hatchways between each of the rooms. At one point, Rennes throws the boot in and does not find anything, but detects that the room has dry air, and deduces that it most likely employs an electrochemical sensor, which detects hydrogen sulphide emitted from the skin. Quentin realizes that Rennes is an escape artist who has escaped more than seven major prisons. Soon after, Rennes jumps into a room tested with a boot, and is sprayed in the face with acid. The others pull him back, but he dies as the acid corrodes his face and the inside of his head. The group decides that the room must have contained an electrochemical sensor which Rennes missed, and realize that they must find a better way of testing the rooms.Quentin asks everyone about their occupations. He says he is a police officer, Holloway says she is a doctor, and Worth says he works \"in an office building, doing office building stuff.\" Leaven claims simply to \"hang out\" with her friends. Quentin believes that nothing is a coincidence, that each of them has a purpose in the cube. After Holloway talks about her rings and broaches, Quentin asks why Leaven has her glasses, while Holloway has had her jewellery taken away. Leaven reveals herself to excel at mathematics, and after looking at the numbers on a crawlspace, theorizes that when one of those numbers is prime, the room is booby-trapped.Leaven's purpose becomes attempting to \"crack the Cube's code\", and they progress through the cubes. When they find themselves in a room with trapped rooms all around and below, Quentin checks the door in the ceiling, through which falls a seventh person: Kazan (Andrew Miller). He appears to be mentally handicapped. At least two of the others see him as a burden, but Holloway decides to bring him along.The group starts speculating about their surroundings, which causes a conflict between Quentin and Holloway. Quentin dismisses Holloway's ideas as conspiracy theories, and Holloway thinks that Quentin is naive. Soon after this, Quentin enters a room without prime numbers and narrowly avoids death from a trap consisting of rotating razor wires. Leaven's theory that non-prime-numbered rooms are safe is shown to be incorrect. Quentin begins suspecting that Worth is a spy, and is increasingly irritated by Kazan's mental state. The group rests, while Leaven attempts to decipher the numbers", "neg": "The figure of a limp woman with long curly hair is seen drifting underwater, and a voiceover questions the end of a life that never truly existed. This life ended in murder, the victim herself unsure of who her killer was and why she was killed. Her death was only metaphorical, for in her place a new life begins.The story starts with Patience Phillips (Halle Berry), a timid woman who can't stand up for herself. She lets people walk all over her, and has wasted her artistic talent working for a cosmetic company as a graphic designer. George Hedare (Lambert Wilson) runs the company with his supermodel wife, Laurel (Sharon Stone). Laurel knows that Patience is capable, but seems mostly indifferent, only using her in own power struggles with her husband. George, an abusive boss in general, finds plenty of opportunity to mock Laurel.The company is about to launch BeauLine, a new anti-aging product that Laurel had secretly been using for years. The advertisement is designed by Patience but George, unsatisfied, demands that she redesigns it. Upset and frustrated, Patience returns home and sees a cat looking up at her. Shaking her head, she goes to sleep, but her loud neighbours keeps her up and she is unable to rest. Next morning, the cat is on her window ledge. When she approaches, she realizes the cat has climbed up to a higher ledge and was potentially stuck. To try and reach the cat, Patience climbs out her window ledge, and a passing detective mistakens her intentions as suicidal. He ends up rushing into her apartment and pulling her back in. Patience would have thanked him but realizes she is late for work, in her hurry to leave she drops her wallet. The detective, Tom Lone (Benjamin Bratt), tracks her down to her workplace and returns it to her, and both agree to a coffee date.Later that night, Patience goes to the production factory to deliver her artwork, and she accidentally hears that the BeauLine has unsafe health problems. Stunned, she backs into several tools, revealling her presence. Two men chase her into a large waste water pipe, where she is trapped, and they flush her into the river, where she drowns. The cat that has been appearing in front of Patience appears by her body and gathers several other cats around her.Patience eventually drags herself unsteadily up and returns home. Her movements are off and uncontrollable, and she ends up breaking the glass through her own window. When her neighbours start their usual loud party again, she yells at them to quiet but they again ignore her. The old Patience would have backed down, but now she strodes down, knocks on their door, and promptly beats up the host and destroys the music equipment in front of many shocked guests. When she wakes up the next morning, she almost dismisses everything as a dream until she sees the broken glass. Unfortunately, her memories of what happened before that are blank, and so she cluelessly returns back to work.At work, George loudly yells at Patience in front of all her coworkers for not handling in her project. She tunes him out, which angers him further, and when she apologizes he only continues. Patience than apologizes for wasting her time in the company, and is fired, but as soon as George leaves her colleagues swarm around her in congratulations. Patience packs up her things and while she and her friends are walking home, two dogs instantly begin barking at her and she instinctively hisses at them. When questioned, she explains her behaviour as allergies. When they pass by a jewelry store, Patience's attention is caught by a beautiful collar-like necklace, but is reminded of her new unemployed status and leaves longingly. Once home, she sees the same cat again, and finally close enough she was able to find the address on the cat's owner.The cat belonged to an older woman named Ophelia, a former professor who lived alone in a house full of cats. She explains that the cat constantly appearing in front of Patience is named Midnight, a rare Egyptian", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}131{"query": "Apolipoprotein A-IV (also known as apoA-IV, apoAIV, or apoA4) is plasma protein that is the product of the human gene APOA4.", "pos": "Cathepsin L2, also known as cathepsin V and encoded by the CTSL2 gene, is a human gene.", "neg": "Carl Michael Bellman was born on 4 February 1740 in the Stora Daurerska house, which was one of the finest in the Sodermalm district of Stockholm.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}132{"query": "Marjorie Bruce or Marjorie de Brus (1296/7 -- 2 March 1316) was the eldest daughter of Robert the Bruce, King of Scots by his first wife, Isabella of Mar, and the founder of the Stewart dynasty.", "pos": "Isabella of France (1295 -- 22 August 1358), sometimes described as the She-Wolf of France, was Queen of England as the wife of Edward II. She was the youngest surviving child and only surviving daughter of Philip IV of France and Joan I of Navarre.", "neg": "Carl Michael Bellman was born on 4 February 1740 in the Stora Daurerska house, which was one of the finest in the Sodermalm district of Stockholm.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}133{"query": "The Quai Saint-Michel and Notre-Dame is a 1901 oil on canvas painting by the French artist Maximilien Luce.", "pos": "Oedipus and the Sphinx is an 1864 oil on canvas painting by Gustave Moreau that was first exhibited at the French Salon of 1864 where it was an immediate success.", "neg": "Maria Schalcken (1645 -- 1699), was a Dutch Golden Age painter, sister and pupil of Godfried Schalcken.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}134{"query": "The basic building blocks of the human body are cells. Human cells are organized into tissues, tissues are organized into organs, and organs are organized into organ systems. The average human adult consists of an incredible 100 trillion cells! Cells are the basic units of structure and function in the human body, as they are in all living things. Each cell must carry out basic life processes in order to survive and help keep the body alive. Most human cells also have characteristics for carrying out other, special functions. For example, muscle cells have extra mitochondria to provide the energy needed to move the body. You can see examples of these and some other specialized human cells in Figure 16.1. To learn more about specialized human cells and what they do, watch this video: . MEDIA Click image to the left or use the URL below. URL: Specialized cells are organized into tissues. A tissue is a group of specialized cells of the same kind that perform the same function. There are four basic types of human tissues: connective, epithelial, muscle, and nervous tissues. The four types are shown in Figure 16.2. Connective tissue consists of cells that form the bodys structure. Examples include bone and cartilage, which protect and support the body. Blood is also a connective tissue. It circulates and connects cells throughout the body. Epithelial tissue consists of cells that cover inner and outer body surfaces. Examples include skin and the linings of internal organs. Epithelial tissue protects the body and its internal organs. It also secretes substances such as hormones and absorbs substances such as nutrients. Muscle tissue consists of cells that can contract, or shorten. Examples include skeletal muscle, which is attached to bones and makes them move. Other types of muscle include cardiac muscle, which makes the heart beat, and smooth muscle, which is found in other internal organs. Nervous tissue consists of nerve cells, or neurons, which can send and receive electrical messages. Nervous tissue makes up the brain, spinal cord, and other nerves that run throughout the body. The four types of tissues make up all the organs of the human body. An organ is a structure composed of two or more types of tissues that work together to perform the same function. Examples of human organs include the skin, brain, lungs, kidneys, and heart. Consider the heart as an example. Figure 16.3 shows how all four tissue types work together to make the heart pump blood. Human organs are organized into organ systems. An organ system is a group of organs that work together to carry out a complex function. Each organ of the system does part of the overall job. For example, the heart is an organ in the circulatory system. The circulatory system also includes the blood vessels and blood. There are many different human organ systems. Figure 16.4 shows six of them and gives their functions. The organ systems of the body work together to carry out life processes and maintain homeostasis. The body is in homeostasis when its internal environment is kept more-or-less constant. For example, levels of sugar, carbon dioxide, and water in the blood must be kept within narrow ranges. This requires continuous adjustments. For example: After you eat and digest a sugary snack, the level of sugar in your blood quickly rises. In response, the endocrine system secretes the hormone insulin. Insulin helps cells absorb sugar from the blood. This causes the level of sugar in the blood to fall back to its normal level. When you work out on a hot day, you lose a lot of water through your skin in sweat. The level of water in the blood may fall too low. In response, the excretory system excretes less water in urine. Instead, the water is returned to the blood to keep water levels from falling lower. What happens if homeostasis is not maintained? Cells may not get everything they need, or toxic wastes may build up in the body. If homeostasis is not restored, it may cause illness or even death.", "pos": "The immune system is the body system that fights to protect the body from specific pathogens. It has a special response for each type of pathogen. The immune systems specific reaction to a pathogen is called an immune response. The immune system is shown in Figure 21.13. It includes several organs and a network of vessels that carry lymph. Lymph is a yellowish liquid that normally leaks out of tiny blood vessels into spaces between cells in tissues. When inflammation occurs, more lymph leaks into tissues, and the lymph is likely to contain pathogens. Immune system organs include bone marrow, the thymus gland, the spleen, and the tonsils. Each organ has a different job in the immune system. Bone marrow is found inside many bones. Its role in the immune system is to produce white blood cells called lymphocytes. The thymus gland is in the chest behind the breast bone. It stores some types of lymphocytes while they mature. The spleen is in the abdomen below the lungs. Its job is to filter pathogens out of the blood. The two tonsils are located on either side of the throat. They trap pathogens that enter the body through the mouth or nose. Lymph vessels make up a circulatory system that is similar to the blood vessels of the cardiovascular system. However, lymph vessels circulate lymph instead of blood, and the heart does not pump lymph through the vessels. Lymph that collects in tissues slowly passes into tiny lymph vessels. Lymph then travels from smaller to larger lymph vessels. Muscles around the lymph vessels contract and squeeze the lymph through the vessels. The lymph vessels also contract to help move the lymph along. Eventually, lymph reaches the main lymph vessels, which are located in the chest. From these vessels, lymph drains into two large veins of the cardiovascular system. This is how lymph returns to the blood. Before lymph reaches the bloodstream, it passes through small oval structures called lymph nodes, which are located along the lymph vessels. Figure 21.14 shows where some of the bodys many lymph nodes are concentrated. Lymph nodes act like filters and remove pathogens from lymph. A lymphocyte is the type of white blood cell involved in an immune system response. You can see what a lymphocyte looks like, greatly magnified, in Figure 21.15. Lymphocytes make up about one quarter of all white blood cells, but there are trillions of them in the human body. Usually, fewer than half of the bodys lymphocytes are in the blood. The majority are in the lymph, lymph nodes, and lymph organs. There are two main types of lymphocytes, called B cells and T cells. Both types of lymphocytes are produced in bone marrow. They are named for the sites where they grow and mature. The B in B cells stands for bone marrow, where B cells mature. The T in T cells stands for thymus gland, where T cells mature. Both B cells and T cells must be switched on in order to fight a specific pathogen. Once this happens, they produce an army of cells that are ready to fight that particular pathogen. How can B and T cells recognize specific pathogens? Pathogens have unique antigens, often located on their cell surface. Antigens are proteins that the body recognizes either as self or nonself. Self antigens include those found on red blood cells that determine a persons blood type. Generally, the immune system doesnt respond to self antigens. Nonself antigens include those found on bacteria, viruses, and other pathogens. Nonself antigens are also found on other cells, such as pollen cells and cancer cells. It is these antigens that trigger an immune response. There are two different types of immune responses. Both types involve lymphocytes. However, one type of response involves B cells. The other type involves T cells. B cells respond to pathogens in the blood and lymph. Most B cells fight infections by making antibodies. An antibody is a large, Y-shaped molecule that binds to an antigen. Each antibody can bind with just one specific type of antigen. The antibody and antigen fit together like a lock and key. You can see how this works in Figure 21.16. The antibody in", "neg": "Microscopes, tools that you may get to use in your class, are some of the most important tools in biology ( Figure Microscopy is the study of small objects using microscopes. Look at your fingertips. Before microscopes were invented in 1595, the smallest things you could see on yourself were the tiny lines in your skin. But what else is hidden in your skin? Over four hundred years ago, two Dutch spectacle makers, Zaccharias Janssen and his son Hans, were experimenting with several lenses in a tube. They discovered that nearby objects appeared greatly enlarged, or magnified. This was the forerunner of the compound microscope and of the telescope. In 1665, Robert Hooke, an English natural scientist, used a microscope to zoom in on a piece of cork - the stuff that makes up the stoppers in wine bottles, which is made from tree bark. Inside of cork, he discovered tiny structures, which he called cells. It turns out that cells are the smallest structural unit of living organisms. This finding eventually led to the development of the theory that all living things are made of cells. Without microscopes, this discovery would not have been possible, and the cell theory would not have been developed. Hookes discovery of the cell set the stage for other scientists to discover other types of organisms. After Hooke, the \"father of microscopy,\" Dutch scientist Antoine van Leeuwenhoek ( Figure 1.2) taught himself to make one of the first microscopes. In one of his early experiments, van Leeuwenhoek took a sample of scum from his own teeth and used his microscope to discover bacteria, the smallest living organism on the planet. Using microscopes, van Leeuwenhoek also discovered one-celled protists and sperm cells. Today, microscopes are used by all types of scientists, including cell biologists, microbiologists, virologists, forensic scientists, entomologists, taxonomists, and many other types. Antoine van Leeuwenhoek, a Dutch cloth merchant with a passion for microscopy. Some modern microscopes use light, as Hookes and van Leeuwenhoeks did. Others may use electron beams or sound waves. Researchers now use these four types of microscopes: 1. Light microscopes allow biologists to see small details of a specimen. Most of the microscopes used in schools and laboratories are light microscopes. Light microscopes use lenses, typically made of glass or plastic, to focus light either into the eye, a camera, or some other light detector. The most powerful light microscopes can make images up to 2,000 times larger. 2. Transmission electron microscopes (TEM) focus a beam of electrons through an object and can make an image up to two million times bigger, with a very clear image. 3. Scanning electron microscopes (SEM) allow scientists to find the shape and surface texture of extremely small objects, including a paperclip, a bedbug, or even an atom. These microscopes slide a beam of electrons across the surface of a specimen, producing detailed maps of the surface of objects. Magnification in a SEM can be controlled over a range from about 10 to 500,000 times. 4. Scanning acoustic microscopes use sound waves to scan a specimen. These microscopes are useful in biology and medical research. Scanning Electron Microscope at (5:04) Click image to the left or use the URL below. URL: 1. How is the electron beam focused? 2. What part of a specimen does a scanning electron microscope look at? 3. Why is it important that a specimen for an electron microscope be placed in a vacuum? Why is this step unnecessary for a light microscope?", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}135{"query": "The China Davis Cup team represents the People's Republic of China in Davis Cup tennis competition and are governed by the Chinese Tennis Association.", "pos": "The 2009 Grand Prix SAR La Princesse Lalla Meryem was a tennis tournament played on outdoor clay courts.", "neg": "Somharuthai Jaroensiri is a retired female badminton player from Thailand.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}136{"query": "The 2010 United States Census reported that Marin County had a population of 252,409. The racial makeup of Marin County was 201,963 (80.0%) White (U.S. Census), 6,987 (2.8%) African American (U.S. Census), 1,523 (0.6%) Native American (U.S. Census), 13,761 (5.5%) Asian (U.S. Census), 509 (0.2%) Pacific Islander (U.S. Census), 16,973 (6.7%) from Race (United States Census), and 10,693 (4.2%) from two or more races. Hispanic (U.S. Census) or Latino (U.S. Census) of any race were 39,069 persons (15.5%).", "pos": "As of the census of 2000, there were 445,342 people, 169,162 households, and 114,015 families residing in the county. The population density was 615 people per square mile (238/km). There were 178,913 housing units at an average density of 247 per square mile (95/km). The racial makeup of the county was 82.19% Race (United States Census), 1.15% Race (United States Census) or Race (United States Census), 0.65% Race (United States Census), 6.68% Race (United States Census), 0.30% Race (United States Census), 5.86% from Race (United States Census), and 3.17% from two or more races. 11.17% of the population were Race (United States Census) or Race (United States Census) of any race. 17.2% were of German American, 9.9% English American, 8.2% Irish American, and 6.7% Americans ancestry. 81.7% spoke only English at home, while 9.6% spoke Spanish and 1.2% Vietnamese.", "neg": "The heat that is used for geothermal power may come to the surface naturally as hot springs or geysers, like The Geysers in northern California. Where water does not naturally come to the surface, engineers may pump cool water into the ground. The water is heated by the hot rock and then pumped back to the surface for use. The hot water or steam from a geothermal well spins a turbine to make electricity. Geothermal energy is clean and safe. The energy source is renewable since hot rock is found everywhere in the Earth, although in many parts of the world the hot rock is not close enough to the surface for building geothermal power plants. In some areas, geothermal power is common (Figure 1.1). In the United States, California is a leader in producing geothermal energy. The largest geothermal power plant in the state is in the Geysers Geothermal Resource Area in Napa and Sonoma Counties. The source of heat is thought to be a large magma chamber lying beneath the area. Where Earths internal heat gets close to the surface, geothermal power is a clean source of energy. In California, The Geysers supplies energy for many nearby homes and businesses. Click image to the left or use the URL below. URL: Click image to the left or use the URL below. URL:", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}137{"query": "New England, the late 1950s. Todd Anderson (Ethan Hawke), a lonely and painfully shy teenager, who is under pressure by his stern parents because he must live up to his older brother's reputation to attend Yale and become a lawyer, arrives for the new semester at the Welton Academy for boys -- Todd's brother also attended Welton and was a popular and well-regarded student there. This semester begins during an orientation gathering with a speech given by the stern Headmaster Nolan (Norman Lloyd), who states the academy's four pillars: Tradition, Honor, Discipline, and Excellence. Todd meets Neil Perry (Robert Sean Leonard) an ambitious student whom becomes his dorm roommate.Later in his dorm, Neil is ordered by his grumpy and domineering father (Kurtwood Smith) to drop his involvement with the school annual in order to maintain good grades so the boy may become a doctor much as he has done. Neil is under pressure from his stern father's will. Also, Mr. Perry tells Neil that Mrs. Perry also wants him to become a doctor, which further worries the boy. A little later, Todd tells Neil that he is in a similar situation with his parents involving his older brother who also attended Welton a few years ago, graduated, and attended Yale Law School and became a lawyer and his parents want the exact same thing for him. But Todd does not have the courage to tell his parents that he instead wants to be a writer, not a lawyer.During the first day of classes Todd and Neil experience the various teaching methods which include speeches by the trig teacher, as well as the Latin teacher, and the math teacher who states that \"all 20 questions at the end of the first chapter are due tomorrow\". In stark contrast to these orthodox teaching methods, the guys see a different side of the school when they attend English class taught by the newly arrived (and liberal-minded) Mr. Keating (Robin Williams), whom they met briefly during the orientation -- Keating tells his class he was also a student at Welton (\"Helton\" as the students secretly refer to the institution) himself many years ago. Keating enters his class whistling the 1812 Overture, and he first takes the boys out in the hallway to the school's displays cases containing artifacts of the school's sports achievements. He tells them that they all have the potential to become powerful individuals, and they are responsible for what their futures will hold. These two actions show his difference from the other teachers because no other teacher would commit the actions he does. Also, he tells the boys they may call him \"Oh Captain, my Captain\", if they dare. These examples of Mr. Keating's teachings show the boys how to think for themselves. Mr. Keating then tells the boys \"Carpe Diem\", which is Latin for \"seize the day\".In addition to Todd and Neil, a small group of other students whom include the lovesick Knox Overstreet (Josh Charles), the flip Charlie Dalton (Gale Hansen), the pragmatic Richard Cameron (Dylan Kussman), liberal Steven Meeks (Allelon Ruggiero) and the moderate Gerard Pitts (James Waterston), also react to the first day's lesson with comments from \"that was weird\" to \"neat\". Cameron asks if anything Keating told them will be on a future test and the boys respond with mild scorn.The next day Keating starts the class with a traditional teaching approach by having Neil read out loud the introduction to their poetry textbook, which describes how to rate the quality of poetry according to mathematical plotting. Keating finds such mathematical criticism ridiculous and instructs his pupils to rip out the essay which is one of three ways that he demonstrates freedom of expression and non-conformity. When some students hesitate, he tells them \"this is not the Bible. This is a battle, a war. You will have to learn to think for yourselves.\" He later has the students stand on his desk as a reminder to look at the world in a different way.A few days later, Knox Overstreet is asked to attend a dinner party at the Danburry", "pos": "Loosely based on the 1967 folk song by Bobbie Gentry, and set in the year 1953 in rural Mississippi, the film explores the budding relationship between 19-year-old Billy Joe McAllister (Robby Benson) and 16-year-old Bobbie Lee Hartley (Glynnis O'Connor) (who corresponds with the unnamed narrator of the original song), despite resistance from Hartley's family, who contend she is too young to date. Yet every day, after being dropped off by her school bus at the Tallahatchie Bridge over the Tallahatchie River which leads to the Hartley farm, Bobbie Lee slips away to a local sawmill where Billy Joe works just to hang out with him at the end of his shift.When Bobbie Lee and her father have a confrontation with three thugs driving a battered pick-up truck from a neighboring county across the state line in Alabama, they chase them to the Tallahatchie where they force their truck off the road which ends up dangling off the bridge. With Bobbie Lee's father unwilling to abandon his truck and abandon the precious eggs and cargo he is delivering to the local market, Bobbie Lee is forced to run several miles to the sawmill to ask Billy Joe, her brother and another employee to rescue her father and save his truck. This incident seem to bring Bobbie Lee and Billy Joe more close to each other.One night at a jamboree, Billy Joe gets drunk and seems nauseated and confused when entering a makeshift whorehouse behind the gathering. Later, Bobbie Lee finds out through the town grapevine that Billy Joe was accused of assaulting one of the prostitutes and is wanted for questioning.After disappearing for days, Billy Joe returns to bid an enigmatic goodbye to Bobbie Lee on the Tallahatchie Bridge. When she presents him with her childhood rag doll, he knocks it away from her and it falls into the river while the passing priest, Brother Taylor, sees from afar. After Billy Joe runs off, Bobbie Lee asks if everything is all right and Billy Joe then blurts out: \"It ain't all right! I have been with a man... which is a sin against nature, a sin against God!\" It is here where he confides in her that on the evening during the jamboree, in his inebriated state, he had sex with another man. Bobbie Lee is somewhat shaken but takes the news very calmly. Overcome with guilt over his homosexual encounter, Billy Joe subsequently kills himself by jumping off the Tallahatchie bridge the next day (off-camera).In the film's final scene, set a few days later after Billy Joe's funeral, Bobbie Lee meets Dewey Barksdale (James Best), Billy Joe's sawmill boss on the bridge as she is leaving town for a while, and he guiltily confesses to her that he was the man whom had sexual relations with Billy Joe that night. She tells Dewey, who is on his way to her house to confess to her father, that the town already falsely suspects that she is carrying Billy Joe's baby and that it would do no good for Dewey to confess now since he could go to prison for sodomy charges. Agreeing with the girl's logic, Dewey offers Bobbie Lee a ride to the bus station, which she courteously accepts.The rest of the story (and song) is history: \"A year has come and gone since we heard the news about Billy Joe. Brother married Becky Thompson and they bought a store in Tupelo. There was a virus goin' around, Papa caught it and he died last spring. And now Mama doesn't wanna do much of anything. And me, I spend a lot of time picking flowers up on Choctaw Ridge and dropping 'em into the muddy waters off the Tallahatchie Bridge.\"", "neg": "Cristina Moreno (Shelbie Bruce - Aimee Garcia as narrator) is applying to Princeton University. For her application essay, she tells the story of her childhood and narrates throughout the movie. Flor Moreno (Paz Vega) is a poor Mexican single mother who moved to America to have a better life for her and her daughter, Cristina (Shelbie Bruce). When she could not maintain her two jobs due to the safety of her daughter, Flor's cousin takes her to a job interview as a nanny for the Claskys, consisting of John (Adam Sandler) and Deborah Clasky (Tea Leoni), their children Bernice (Sarah Steele) and Georgie (Ian Hayland), and Deborah's mother Evelyn Wright (Cloris Leachman). John is a man who cares about cooking good food and raising his kids. Deborah is a former businesswoman turned stay-at-home mother, and Evelyn is a raging alcoholic. Deborah is uptight and her neurotic behavior often upsets the family: she mentally abuses her daughter to exercise by buying her smaller-sized clothes and putting her down for certain behaviors, and she mentally abuses her husband by telling him to co-parent with her on their son, but she really wants him to be submissive to her parenting instead. John is more laid back and supports the mental well-being of his children, but he feels he cannot stand up to Deborah on her parenting and often leaves it as it is. Summer comes and Flor is needed 24/7 at the Claskys' summer home. Unable to communicate well in English, Deborah finds a neighbor to interpret. Flor admits she is unable to maintain these hours because she has a daughter; out of desperation to keep Flor as their nanny, Deborah invites Cristina to come stay with them, acting as interpreter for her mother. Deborah immediately becomes attached to Cristina when she first arrived due to her beauty and begins to treat her more like a daughter than Bernice, taking Cristina shopping, buying her gifts, and getting her hair done. To make Cristina feel more comfortable, John gives the children a small glass-collecting project in which they receive money and includes Cristina. She was given $640 for her glass collection, which Flor finds out. The two argue with Cristina as the interpreter, and Flor wants to leave because of the awkwardness it will create afterwards, but John coaxed her into staying. She begins to learn English so she can communicate better with the Claskys. In the meantime, John opens a new restaurant, but falls into a temporary depression because of the stress of the business, and Deborah is having an affair, dressing provocatively and leaving only at nighttime. She enrolls Cristina into a private school with Bernice, upsetting Flor, who wants Cristina to keep in touch with her Mexican roots and working-class values. She feels Deborah is overstepping her bounds and voices her objection to John, who tells her he is just as stressed because Bernice has no support system from her own mother. Summer is over and it is Cristina's and Bernice's first day of school; that afternoon, Cristina was allowed to bring friends back to the Clasky's home from school, but not Bernice. Deborah tries to cover for Cristina to keep her there, but an angry Flor marches to her place. The now-sober Evelyn realizes that her daughter is having an affair and that her marriage is in trouble. She pleads with Deborah to end the affair, telling her she will never get another man as good as John. Deborah confesses to John that she cheated on him and begs him to stay so the two could talk everything over; however, John walks out and bumps into Flor, who was trying to tell him that she is quitting. He offers to give Flor a ride in his car, but he wanted to \"hang out\" when they arrived at her bus stop, and they ended up going to his restaurant, where he cooks for Flor. They become extremely close to the point of falling in love, but Flor is afraid of the consequences of having an affair while they both have kids. While the two enjoyed the", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}138{"query": "Isias was the daughter of King Ariobarzanes I of Cappadocia and his wife Queen Athenais Philostorgos I, while her brother was King Ariobarzanes II of Cappadocia.", "pos": "Judah ben Asher (June 30, 1270 -- July 4, 1349) was a German Talmudist and later rabbi of Toledo, Spain, son of Rabbenu Asher and brother of Jacob ben Asher (''Ba'al ha-Turim'').", "neg": "Catherine Antonovna of Brunswick-Luneburg (1741--1807), daughter of Duke Anthony Ulrich of Brunswick and Grand Duchess Anna Leopoldovna of Russia.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}139{"query": "In late July, Danzig was re-inforced by a Dutch garrison, and a combined Danish and Dutch fleet broke the naval blockage imposed on Danzig by Charles X Gustav. On 28-30 July, a combined Brandenburgian-Swedish army was able to defeat the Polish-Lithuanian army in the Battle of Warsaw, forcing John II Casimir to retreat to Lublin. In August, Alexis' army took Livonian Kokenhausen , laid siege to Riga and Dorpat and raided Estonia, Ingria and Kexholm. On 4 October, John II Casimir stormed eczyca in Greater Poland before heading for Royal Prussia, and on 8 October, Wincenty Korwin Gosiewski with 12,000 to 13,000 Lithuanian and Crimean Tartar cavalry overran a Brandenburgian-Swedish force in the Battle of Prostken in Ducal Prussia. Gosiewski then ravaged Ducal Prussia, burning 13 towns and 250 villages, in a campaign that entered folklore because of the high death toll and the high number of captives deported to the Crimea. On 22 October, Gosiewski was defeated by Swedish forces in the Battle of Filipow and turned to Lithuania. Also on 22 October, besieged Dorpat surrendered to Alexis, while the Russian siege of Swedish-held Riga was lifted. John II Casimir meanwhile took Bromberg and Konitz in Royal Prussia, and from 15 November 1656 until February 1657 stayed in Danzig, where a Swedish siege had to be lifted due to Dutch intervention, just 55 kilometers away from Charles X Gustav's quarters in Elbing.", "pos": "The Lithuanian Civil War of 1432-1438 was a conflict over the succession to the throne of the Grand Duchy of Lithuania, after Vytautas the Great died in 1430 without leaving an heir. The war was fought on the one side by Svitrigaila, allied with the Teutonic Knights, and on the other by Sigismund Kestutaitis, backed by the Kingdom of Poland. The war threatened to sever the Union of Krewo, the personal union between Poland and Lithuania. Svitrigaila's alliance with the Grand Master of the Teutonic Order, Paul von Rusdorf, launched the Polish-Teutonic War but failed to secure victory for Svitrigaila. When Sigismund captured power in Lithuania by staging a coup in 1432, Lithuania split into two opposing camps, and there began three years of devastating hostilities. To prevent the Knights from continuing their support of Svitrigaila, Poland backed a Hussite invasion of Prussia in 1433. The war ended in a decisive defeat for Svitrigaila and his ally, the Livonian branch of the Teutonic Knights, at the Battle of Pabaiskas in September 1435. Svitrigaila eventually surrendered in 1437; Sigismund Kestutaitis ruled Lithuania for only eight years before he was assassinated in 1440.", "neg": "The rebellion of the city of Danzig was a revolt from December 1575 to December 1577 of the city against the outcome of the Polish-Lithuanian royal election, 1576. The Polish throne was contested by Stephen Bathory and the Holy Roman Emperor Maximillian II. It began on 12 December 1575 when Emperor Maximillian was chosen as monarch by the Polish Senate, while the majority of the szlachta had voted for Bathory. It ended on 16 December 1577. Maximilian's II death in fall of 1576 weakened Danzig's position and made the conflict less about the recognition of the ruler than about Danzig's privileges. With neither side being able to defeat the other militarily, a compromise was reached, with economic as well as religious privileges of the city being restored and recognized, in return for a large reparation and recognition of Bathory as the king.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}140{"query": "In the opening scene, private detective Sam Grunion (Groucho Marx) explains to the viewers that he has been searching for the extremely valuable Royal Romanoff diamonds for eleven years, and his investigation leads him to a troupe of struggling performers, led by Mike Johnson (Paul Valentine), who are trying to put on a musical revue called 'Love Happy'.Grunion notes that the impoverished young dancers would starve were it not for the sweet, silent Harpo (Harpo Marx), at Herbert & Herbert, a gourmet food shop that also trafficks in stolen diamonds. Harpo kindly helps ladies with their shopping bags, all the while pilfering their groceries and stuffing them in the pockets of his long trench coat. When the elegant Madame Egelichi (Ilona Massey) arrives, store manager Lefty Throckmorton (Melville Cooper) tells her that \"the sardines\" have come in. Harpo sneaks into the basement and watches as Lefty lovingly unpacks a sardine can marked with a Maltese cross, and swipes the can from Lefty's pocket, replacing it with an unmarked one. Madame Egelichi, who has gone through eight husbands in three months in her quest for the Romanoff diamonds, is furious when Lefty produces the wrong can. When Lefty remembers seeing Harpo in the basement, she orders him to call the police and offer a $1,000 reward for his capture.At the theater, meanwhile, unemployed entertainer Faustino the Great (Chico Marx) asks Mike for a job as a mind-reader, and when Faustino's clever improvisation stops the show's backer, Mr. Lyons (Leon Belasco), from repossessing the scenery, Mike gratefully hires him. Harpo, who is secretly in love with dancer Maggie Phillips (Vera-Ellen), Mike's girl friend, gives her the sardine can, and she says she will eat them tomorrow. A policeman sees Harpo inside the theater and brings him to Madame Egelichi, who turns Harpo over to her henchmen, Alphonse (Raymond Burr) and Hannibal (Bruce Gordon) Zoto. After three days of interrogation, Harpo still refuses to talk, and when he is left alone, he calls Faustino at the theater, using the bike horn he carries in his pocket to communicate. Madame Egelichi listens on the extension as Faustino declares that there are plenty of sardines at the theater, and she goes there at once.Meanwhile, Mike has just finished telling the troupe that they do not have enough money to open when Madame Egelichi arrives and offers to finance the show. Mike cancels his plans to take Maggie out for her birthday so that he and his new backer can discuss the arrangements. In the alley outside the theater, Harpo, having escaped from Madame Egelichi's suite, finds the diamonds in the sardine can which had been set out for a cat, and puts them in his pocket. When he finds Maggie crying in her dressing room, Harpo takes her to Central Park, where he plays the harp for her and gives her the diamonds as a birthday gift.On the opening night of the show, Grunion is visited by an agent of the Romanoff family, who threatens to kill him if he does not produce the diamonds in an hour. At the theater, Lefty and the Zoto brothers spy through a window as Maggie puts on the diamond necklace, but Mike asks her not to wear it, promising to buy her an engagement ring instead. As they kiss, Maggie removes the necklace and drops it on the piano strings. The curtain goes up, and when Harpo sees Lefty and the Zoto brothers menacing Maggie, he distracts them with a piece of costume jewelry and leads them up to the roof.Meanwhile, on stage, Faustino plays the piano, and when he strikes the keys forcefully, the diamond necklace flies into the air, drawing the attention of Madame Egelichi, who is watching from the audience. Faustino pockets the diamonds, then rushes to the roof to help Harpo. Madame Egelichi shows up with a gun and demands the necklace, but Faustino gives her the fake diamonds. After tying up Lefty and the Zotos and recovering the real diamonds, Harpo encounters Grunion, who has been hiding on the roof. Harpo drops the diamonds in Grunion", "pos": "Gas station attendant Clint Ramsey, who works at Martin Bormann's Super Service in the desert, finds himself too irresistible to a series of girls, all of whom have the word \"Super\" in their given names. In the beginning, he is married to the hypersexual, demanding, and jealous SuperAngel (Shari Eubank), who constantly harasses him at work. She orders him home at once when she calls Clint and overhears a female customer, SuperLorna (Christy Hartburg), hitting on him at work. Clint finds SuperAngel's constant accusations and arguing a turnoff and, back at home, they fight after he rejects her aggressive advances. A neighbor calls the police as Clint leaves for a local bar, where the bartender is the very scantily clad SuperHaji (Haji). Meanwhile, SuperAngel seduces Harry Sledge (Charles Napier), the cop who responded to the police call. He is impotent and unable to perform. She repeatedly taunts and insults him over this, which finally results in him killing her by stomping her brutally in a bathtub, then throwing a radio in the water which was plugged into the wall socket. Sledge burns down the house, then tries to pin the murder on Clint. Clint claims being in the pub all night, but SuperHaji has her revenge on him (from insulting her breast size earlier) by refusing to confirm his alibi. Clint is then forced to flee. In his rush to escape, Clint hitchhikes a ride from a boy (John LaZar) and his girlfriend SuperCherry (Colleen Brennan). During the drive, SuperCherry comes on to him and puts his hand over her breast, but then pulls it back. She then tries to give him a handjob over his pants, but he continues to resist her advances. The driver takes offense to Clint rejecting his girlfriend, but she says he probably just wants a closer contact. She again attempts and fails to seduce him and he asks the driver to let him get out. The driver follows him out and beats and robs him. Clint is found by an old farmer who takes him to his farm to heal from his injuries and Clint agrees to work for the farmer for a week to repay him. The farmer has a younger Austrian mail-order bride, SuperSoul (Uschi Digard), who is hypersexual. After energetically satisfying her husband, she comes knocking on Clint's door at night. She immediately pushes him into his bed where she proceeds to mount and rape him, until he manages to overpower her. However, she does the same the following day and this time overpowering him after jumping him from behind in the barn. Looking for SuperSoul, the farmer finds them in the barn, then chases Clint away and punches SuperSoul. Fleeing from the farm, Clint meets a motel owner and his deaf daughter, SuperEula (Deborah McGuire), who convinces him to take a ride with her in her dune buggy to have sex in the desert. They are caught by her father and chased out of town. Clint eventually meets up with SuperVixen (also played by Shari Eubank) at Supervixen's Oasis, a roadside diner. SuperVixen is (inexplicably) a friendly and giving reincarnation of SuperAngel, whose ghost now appears nude between scenes to comment on the plot from atop a bedspring balanced on a mesa. Clint and SuperVixen fall in love and are inseparable, although their common nemesis, Harry Sledge, arrives on the scene and plots ending the lives of the now happy couple.", "neg": "Salt Flat Utah, 1873. Stubby Preston (Fabio Testi) a card-shard and gambling trickster, arrives in the small Wild West town to practice his art at the local casino. However, the town sheriff (Donald O'Brien) recognizes him climbing out of the stagecoach and within minutes, he is in a jail cell for the night and his marked cards are burned. Stubby's cell-mates are Emmanuelle 'Bunny' O'Neill (Lynne Frederick) a young prostitute; Bud (Harry Baird), a mentally disturbed black man who is obsessed with the dead; and Clem (Michael J. Pollard), the town drunkard. During the night, a masked posse of men wreck havoc throughout the settlement. Fearing for their safety as the massacre progresses, the prisoners demand to be realeased, but the sheriff refuses. The following morning, the sheriff, amused by Stubby's ways, allows them to leave town, pointing them to an abandoned wagon as their means of transportation. The sheriff also tells them that the massacre was all his idea to reclaim the town from lawlessness.The four released convicts decide to travel together, and Stubby takes a liking to Bunny. As they travel, aiming to his the next big town over 200 miles away, a friendship develops between the four reprobates. During their first stop for the night, Bunny reveals that she's eight months pregnant, having gotten knocked up by a client in Salt Flat and has been hiding it with oversized dresses. The following day, the four have an encounter with a group of Christian missionaries from Switzerland where Stubby has Bunny pose as his wife, who's happy about the charade.Afterwards, the four's idyll is interrupted by appearance of a Mexican sharpshooter called Chaco (Tomas Milian). Despite initial suspicious, he is welcomed into the group. Chaco displays his shooting skills by shooting rabbits and ducks for their meal for the night. But he shows a sinister side when the group is attacked by three posse members from Salt Flat, and Chaco gleefully shoots all three of them, and sadistically tortures the one surviving posse member. That evening, Chaco persuades the group to take peyote with him. Stubby, secretly spits out the hallucinogenic cactus, suspicious alerted, but the rest of the party accepts. Chaco then amuses himself with Clem, humiliating the drug-addled alcoholic by ordering that he crawl and bark like a dog for some liquor. When Stubby attempts to make a run for it, Chaco subdues him and ties up the four travelers at gunpoint. As day breaks, Chaco rapes Bunny despite seeing her condition. Stubby swears to kill Chaco one day if he survives. The evil bandit then rides off on the wagon with all their gear, leaving them tied up in the desert, except for Clem who he shoots in the leg. Clem frees the others and they continue their trek on foot. As Clems wound worsens, Stubby is forced to remove the bullet and he and Bud carry him on a makeshift stretcher. Later, the group comes upon the aftermath of another attack by Chaco and two henchmen. The Christian wagoners, children and all, have all been slaughtered.The group's journey continues. Eventually the four friends see buildings ahead. The arrive in a small town in the pouring rain, but discover that it's a ghost town. The following morning is bright and sunny. Bud is ecastic when he discovers a graveyard full of friends to talk to. That evening, Clem gets more sicker from the infection of his wound. But he makes dying request that Stubby and Bunny to get married. The couple profess their love for one another and they kiss for the first time. The next morning, the couple decide to leave the ghost town. Bud elects to stay behind having learned to hunt animals for food. But Stubby and Bunny discover Clems mutilated dead body and learn that Bud has taken a liking to cannibalism as well. Stubby and Bunny leave Bud and his 'city of the dead' and head on out.A little later, the couple run into another one of Stubby's old acquaintances, the pseudo-Reverend Sullivan (Adolfo Lastretti). Stopping for", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}141{"query": "Mapfanga is a settlement in Kenya's Coast Province.", "pos": "Huruma Estate is a residential estate located in the northeast of Nairobi, the capital of Kenya.", "neg": "Civic Choice (Italian: Scelta Civica, SC) is a centrist and liberal political party in Italy founded by Mario Monti.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}142{"query": "The 80-string koto (or hachijugen) was an invention of Japanese composer Michio Miyagi which appeared In 1923.", "pos": "Stigler's law of eponymy is a process proposed by University of Chicago statistics professor Stephen Stigler in his 1980 publication ''Stigler's law of eponymy''.", "neg": "Arthur Klemt (born 1913 in Offenburg, Baden-Wurttemberg, Germany -- died 1985 in Olching, Bavaria, Germany) was a German inventor.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}143{"query": "Mustafabyli (also Mustafabeyli) is a village in the Saatly Rayon of Azerbaijan.", "pos": "Al-e Yusefi-ye Sofla (Persian: , also Romanized as Al-e Yusefi-ye Sofla; also known as Al-e Safi-ye Pa'in and Al-e Yusefi-ye Pa'in) is a village in Zirrah Rural District, Sadabad District, Dashtestan County, Bushehr Province, Iran.", "neg": "The villages of Villars-Tiercelin, Montaubion-Chardonney, Sottens, Villars-Mendraz and Peney-le-Jorat merged on 1 July 2011 into the new municipality of Jorat-Menthue.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}144{"query": "The rate at which a device changes electric current to another form of energy is called electric power. The SI unit for powerincluding electric poweris the watt. A watt equals 1 joule of energy per second. High wattages are often expressed in kilowatts, where 1 kilowatt equals 1000 watts. The power of an electric device, such as a hair dryer, can be calculated if you know the voltage of the circuit and how much current the device receives. The following equation is used: Power (watts) = Current (amps) Voltage (volts) Assume that Mirandas hair dryer is the only electric device in a 120-volt circuit that carries 15 amps of current. Then the power of her hair dryer in kilowatts is: Power = 15 amps 120 volts = 1800 watts, or 1.8 kilowatts Q: If a different hair dryer is plugged into a 120-volt circuit that carries 10 amps of current. What is the power of the other hair dryer? A: Substitute these values in the power equation: Power = 10 amps 120 volts = 1200 watts, or 1.2 kilowatts Did you ever wonder how much electrical energy it takes to use an appliance such as a hair dryer? Electrical energy use depends on the power of the appliance and how long it is used. It can be calculated with this equation: Electrical Energy = Power Time If Miranda uses her 1.8-kilowatt hair dryer for 0.2 hours, how much electrical energy does she use? Electrical Energy = 1.8 kilowatts 0.2 hours = 0.36 kilowatt-hours Electrical energy use is typically expressed in kilowatt-hours, as in this example. How much energy is this? One kilowatt-hour equals 3.6 million joules of energy. Q: Suppose Miranda were to use a 1.2-kilowatt hair dryer for 0.2 hours. How much electrical energy would she use then? A: She would use: Electrical Energy = 1.2 kilowatts 0.2 hour = 0.24 kilowatt-hours", "pos": "For electric current to flow through a wire, there must be a source of voltage. Voltage is a difference in electric potential energy. As you might have guessed, greater voltage results in more current. As electric current flows through matter, particles of matter resist the moving charges. This is called resistance, and greater resistance results in less current. These relationships between electric current, voltage, and resistance were first demonstrated in the early 1800s by a German scientist named Georg Ohm, so they are referred to as Ohms law. Ohms law can be represented by the following equation. Current(amps) = Voltage(volts) Resistance(ohms) Ohms law may be easier to understand with an analogy. Current flowing through a wire is like water flowing through a hose. Increasing voltage with a higher-volt battery increases the current. This is like opening the tap wider so more water flows through the hose. Increasing resistance reduces the current. This is like stepping on the hose so less water can flow through it. You can use the equation for current (above) to calculate the amount of current flowing through a circuit when the voltage and resistance are known. Consider an electric wire that is connected to a 12-volt battery. If the wire has a resistance of 2 ohms, how much current is flowing through the wire? Current = 12 volts 2 ohms = 6 amps Q: If a 120-volt voltage source is connected to a wire with 10 ohms of resistance, how much current is flowing through the wire? A: Substitute these values into the equation for current: Current = 120 volts 10 ohms = 12 amps", "neg": "Work is the use of force to move an object. It is directly related to both the force applied to the object and the distance the object moves. Work can be calculated with this equation: Work = Force x Distance. The equation for work can be used to calculate work if force and distance are known. To use the equation, force is expressed in Newtons (N), and distance is expressed in meters (m). For example, assume that Clarissa uses 100 Newtons of force to push the mower and that she pushes it for a total of 200 meters as she cuts the grass in her grandmothers yard. Then, the amount of work Clarissa does is: Work = 100 N 200 m = 20,000 N m Notice that the unit for work in the answer is the Newton meter (N m). This is the SI unit for work, also called the joule (J). One joule equals the amount of work that is done when 1 N of force moves an object over a distance of 1 m. Q: After Clarissa mows her grandmothers lawn, she volunteers to mow a neighbors lawn as well. If she pushes the mower with the same force as before and moves it over a total of 234 meters, how much work does she do mowing the neighbors lawn? A: The work Clarissa does can be calculated as: Work = 100 N 234 m = 23,400 N m, or 23,400 J The work equation given above can be rearranged to find force or distance if the other variables are known: Force = Work Distance Distance = Work Force After Clarissa finishes mowing both lawns, she pushes the lawn mower down the sidewalk to her own house. If she pushes the mower over a distance of 30 meters and does 2700 joules of work, how much force does she use? Substitute the known values into the equation for force: J Force = 2700 30 m = 90 N Q: When Clarissa gets back to her house, she hangs the 200-Newton lawn mower on some hooks in the garage (see the Figure 1.1). To lift the mower, she does 400 joules of work. How far does she lift the mower to hang it? A: Substitute the known values into the equation for distance:", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}145{"query": "Le Bassin Aux Nympheas (Water Lily Pond; 1919) is one of the series of Water Lilies paintings by French impressionist artist Claude Monet.", "pos": "The Quai Saint-Michel and Notre-Dame is a 1901 oil on canvas painting by the French artist Maximilien Luce.", "neg": "Maria Schalcken (1645 -- 1699), was a Dutch Golden Age painter, sister and pupil of Godfried Schalcken.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}146{"query": "Hoping to rebound from their home loss to the Titans, the Bears flew to Lambeau Field for a Week 11 NFC North duel with their hated rival, the Green Bay Packers. In the first quarter, Chicago trailed early as Packers QB Aaron Rodgers completed a 3-yard TD pass to WR Greg Jennings. In the second quarter, the Bears got on the board with kicker Robbie Gould getting a 35-yard field goal. Green Bay would answer with RB Ryan Grant getting a 4-yard TD run, along with kicker Mason Crosby getting a 53-yard field goal. In the third quarter, Chicago continued to trail as Rodgers completed a 5-yard TD pass to TE Donald Lee. In the fourth quarter, the Packers pulled away as Crosby made a 33-yard field goal, DE Jason Hunter returned a fumble 54 yards for a touchdown, and Crosby nailing a 45-yard field goal.", "pos": "Coming off their Monday night road win over the Saints, the Vikings went home for a Week 6 NFC North duel with the Detroit Lions. In the first quarter, the Vikes got an early lead as Lions QB Dan Orlovsky unintentionally ran out of the back of his own end zone, giving Minnesota a safety which Orlovsky didn't know why the whistles were blown. In the second quarter, Detroit got the lead as kicker Jason Hanson got a 40-yard field goal. In the third quarter, the Lions increased their lead as Orlovsky completed a 12-yard TD pass to WR Calvin Johnson. The Vikings answered with QB Gus Frerotte completing an 86-yard TD pass to WR Bernard Berrian. In the end of the fourth quarter, the Vikes got in field goal range due to a controversial pass interference call on Leigh Bodden. The Vikes sealed the win with kicker Ryan Longwell nailing the game-winning 26-yard field goal.", "neg": "Coming off a bye week, the Bears battled rival Detroit Lions on Monday Night Football. The team kept the Lions from scoring until the fourth quarter, and forced four takeaways. The first turnover forced was in the first half, when Lance Briggs stripped the ball from Mikel Leshoure, which was recovered by Julius Peppers. The second and third turnovers were forced in the third quarter on Zack Bowman's muffed punt recovery, and Brian Urlacher recovering Joique Bell's fumble. The final turnover occurred when Lions quarterback Matthew Stafford's pass was intercepted by D. J. Moore. The Bears struck first on Jay Cutler's touchdown pass to Brandon Marshall, and Robbie Gould kicked a field goal to increase the first half score to 10-0. During the game, Lions defensive tackle Ndamukong Suh threw Cutler to the ground, injuring his ribs. Cutler was eventually replaced by Jason Campbell for a play, before returning to the game. In the second half, Gould kicked another field goal, and prevented the Lions from scoring until the final 36 seconds of the game, when Stafford threw a 12-yard touchdown pass to Ryan Broyles to narrow the margin to six points, but the Bears sealed the victory by recovering the ensuring onside kick.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}147{"query": "When you enter a crowded room or go on a picnic or to a party, who is the most attractive and appealing person? It is the person who is cheerful, has a smiling face and behaves as if he or she is enjoying every moment of the event! Such people have an optimistic opinion on life. They are the ones with a positive attitude. On the other hand, let's see that fellow in the corner with a long face. He is most probably thinking about the time and money wasted in having fun. He is a pessimist, one with a negative attitude. A person with a positive attitude gets on well with the job at hand. He doesn't worry about what's gone before or what might happen in the future. If there is a problem, he quickly thinks of ways to solve it. If the problem cannot be solved singly, he seeks help from someone else. He doesn't feel that it's beneath his dignity to seek assistance. When Sonal lost her history notes days before an important examination, she sat down and cried. Then she pulled herself together, borrowed a friend's notes, worked day and night and managed to copy down whatever she had lost. Sonal passed the exam with flying color1s. It's just not possible, even for the greatest optimist, to smile all the time and feel good all day. Everyone has a period of blues now and then, when everything seems sad and without cheer. But once you develop a positive attitude, once you realize that life is a series of ups and downs, dark clouds and bright sunshine, in no time at all, you've _ , ready to welcome the world again with open arms and a huge smile! So from this moment on, keep your face to the sunshine and you'll never see the shadows.", "pos": "When my mother was alive, she used to tell me again and again about the value of just being nice. \"Never underestimate the power of a smile,\" she would say. I fear she would be very disappointed looking at the world today. A lot of people don't smile and when it comes to service today, they're just not nice. Now don't give me wrong, not all service workers but a good many. I was on the phone the other day with a computer help desk. First a man, then later a woman, who couldn't have been ruder. And this to a customer, who didn't know his way around a PC. But no matter, I could tell they thought I was a bother, The woman, in fact, seemed to be chewing gum as she unemotionally clicked off a series of commands for me to perform. The next day I heard from a friend of mine who got a performance review without his boss once looking up at him. Not once. You see it everywhere. Gone are the days when people cared about you. It's a sign of the time, I suspect. But that makes me sad -- for them and for us all. People who aren't happy, who don't smile, who don't kid, who don't joke or make light of even bad situations, make for an even worse situation. And it spreads like a cancer. Someone's rude to you, you're rude to them and to the next fellow you meet, and on and on. Smiles are contagious but so annoyances. The boss who can't be bothered with his workers. The celebrity who can't be bothered with her annoying fans. You know, my mom used to judge presidential candidates by how they smiled. I would say, \"But mom, you don't know if that smile is real.\" \"Oh, yes I do,\" she would tell me. \"I can feel it.\" It's in their eyes, she would say. And it's in their smile. The rest just kind of falls into place.", "neg": "With the new school year quickly coming near (or perhaps, for your early-starters, already under way), it's time to get ready for a successful term . And while you may be cleaning your wardrobe , it's equally important to freshen up your study skills, too. Have you ever noticed that your study habits are different from those of your friends? Or how you seem to learn faster in certain classes? Some people are quick to blame the teacher or subject for their difficulties, but that isn't always the cause . One thing that many people seem to ignore is their learning type. Now, you may be wondering what a learning type is and how to find yours. There are three different learning types: Visual, Auditory, and Kinesthetic. You can be a _ of learning types, but most people have one main type. 1. Visual learners learn best by seeing. If you seem to easily get information from pictures, graphs, and videos, you are likely a visual learner. 2. Auditory learners learn best by hearing. If you seem to remember things by hearing them, whether listening to a lecture or repeating information out loud, then you are likely an auditory learner. 3. Kinesthetic learners learn best by doing. If you seem to learn best by working with your hands or testing out what you are shown, you are likely a kinesthetic learner. So now that you know your personal learning style, the trick is to find out how to use your new-found knowledge to help you in your classes.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}148{"query": "The enzyme telomerase is activated in 80-90% of all human malignancies and immortal cell lines, where it functions to maintain the integrity of chromosomal-end structures called telomeres. Telomerase enzyme activity can be detected in whole cell lysates by a polymerase chain reaction (PCR)-based method referred to as the telomeric repeat amplification protocol (TRAP). The TRAP assay involves extension of an oligonucleotide through telomerase-mediated enzymatic addition of telomeric DNA repeats and subsequent PCR amplification of the extension products. While the TRAP assay as originally developed utilizes radioactively labelled nucleotides, protocols are provided herein for nonradioactive versions of the TRAP assay, with options for either qualitative assessment of TRAP products by polyacrylamide gel electrophoresis (standard TRAP), or quantitative analysis by real-time PCR (Q-TRAP). The Q-TRAP method poses the additional advantages of exquisite sensitivity, rapidity, and potential for adoption to a high-throughput format.", "pos": "The performance of two proteomic sample preparation methods, \"pseudoshotgun\" (PSG) and filter-aided sample preparation (FASP) were compared in terms of the number of identified proteins, representation of cellular component GO (gene ontology) categories in the obtained list of proteins, and the efficiency of both methods in the proteomic analysis of a very low number of cells. Both methods were combined to obtain a proteomic profile of a short-term culture (passage 3) of melanoma cells, established in our laboratory from a human metastatic melanoma lesion. The data revealed that with FASP, usually more proteins are identified than with PSG when analyzing a higher number of cells ( 5000/injection), whereas PSG is favorable when analyzing only a very small amount of cells (250-500/injection). PSG and FASP, however, are complementary techniques, as combining both methods further increases the number of identified proteins. Moreover, we show that it is feasible to identify a substantial number of proteins from only 250 cells/injection that is equivalent to 60 ng of protein.", "neg": "Epidermal growth factor receptor (EGFR) gene mutations have been found in a subset of non-small cell lung cancer (NSCLC) with good clinical response to gefitinib therapy. A quick and sensitive method with large throughput is required to utilize the information to determine whether the molecular targeted therapy should be applied for the particular NSCLC patients. Using probes for the 13 different mutations including 11 that have already been reported, we have genotyped the EGFR mutation status in 94 NSCLC patients using the TaqMan PCR assay. We have also genotyped the EGFR mutations status in additional 182 NSCLC patients, as well as 63 gastric, 95 esophagus and 70 colon carcinoma patients. In 94 NSCLC samples, the result of the TaqMan PCR assay perfectly matched with that of the sequencing excluding one patient. In one sample in which no EGFR mutation was detected by direct sequencing, the TaqMan PCR assay detected a mutation. This patient was a gefitinib responder. In a serial dilution study, the assay could detect a mutant sample diluted in 1/10 with a wild-type sample. Of 182 NSCLC samples, 46 mutations were detected. EGFR mutation was significantly correlated with gender, smoking status, pathological subtypes, and differentiation of lung cancers. There was no mutation detected by the TaqMan PCR assay in gastric, esophagus and colon carcinomas. TaqMan PCR assay is a rapid and sensitive method of detection of EGFR mutations with high throughput, and may be useful to determine whether gefitinib should be offered for the treatment of NSCLC patients. The TaqMan PCR assay can offer us a complementary and confirmative test.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}149{"query": "Children with chromosome 22q11.2 deletion syndrome (22q11.2DS), Fragile X syndrome (FXS), or Turner syndrome (TS) are considered to belong to distinct genetic groups, as each disorder is caused by separate genetic alterations. Even so, they have similar cognitive and behavioral dysfunctions, particularly in visuospatial and numerical abilities. To assess evidence for common underlying neural microstructural alterations, we set out to determine whether these groups have partially overlapping white matter abnormalities, relative to typically developing controls. We scanned 101 female children between 7 and 14years old: 25 with 22q11.2DS, 18 with FXS, 17 with TS, and 41 aged-matched controls using diffusion tensor imaging (DTI). Anisotropy and diffusivity measures were calculated and all brain scans were nonlinearly aligned to population and site-specific templates. We performed voxel-based statistical comparisons of the DTI-derived metrics between each disease group and the controls, while adjusting for age. Girls with 22q11.2DS showed lower fractional anisotropy (FA) than controls in the association fibers of the superior and inferior longitudinal fasciculi, the splenium of the corpus callosum, and the corticospinal tract. FA was abnormally lower in girls with FXS in the posterior limbs of the internal capsule, posterior thalami, and precentral gyrus. Girls with TS had lower FA in the inferior longitudinal fasciculus, right internal capsule and left cerebellar peduncle. Partially overlapping neurodevelopmental anomalies were detected in all three neurogenetic disorders. Altered white matter integrity in the superior and inferior longitudinal fasciculi and thalamic to frontal tracts may contribute to the behavioral characteristics of all of these disorders.", "pos": "Monosomy for the X chromosome is the most frequent cause of Turner's syndrome, a common clinical syndrome associated with particular physical and neurobehavioral features. The results from comprehensive assessment of prepubertal monozygotic female twins discordant for X monosomy are presented. Zygosity was established with DNA Fingerprinting and no evidence of chromosomal mosaicism was seen in either child. Physical features in the affected twin were relatively mild with respect to the full spectrum of physical malformations and disabilities associated with Turner's syndrome. The neurobehavioral phenotypes of the twins were compared. Although both sisters scored in the superior range of intelligence, the affected twin's Performance IQ was 18 points less than her sister, whereas Verbal IQ showed only a 3-point difference between the sisters. Other relative differences were noted within the executive, visuospatial, and visuomotor domains of function. Behavioral evaluation indicated greater problems with attention, hyperactivity, and anxiety in the affected twin. Quantitative analysis of brain anatomy revealed evidence of both general and regional effects of X monosomy on neurodevelopment. Cerebrospinal fluid volume was increased by 25% in the affected twin compared with her sister with a corresponding decrease in gray matter volume. The right frontal, right parietal-occipital, and left parietal-perisylvian regions showed the greatest discrepancy between the sisters with respect to increased cerebrospinal fluid and decreased gray matter volumes in twin with X monosomy. Differences in the posterior fossa were also noted with a 50% relative increase in the volumes of the fourth ventricle and cisterna magna and a 10 to 15% relative reduction in size of the cerebellar vermis, pons, and medulla in the affected twin. The association between the neurobehavioral and neuroanatomical findings in the affected twin is discussed. The unique nature of the naturally occurring genetic phenomenon seen in this twin pair provides an opportunity to more fully elucidate the neurobehavioral phenotype associated with X monosomy and Turner's syndrome.", "neg": "Using post-embedding immunogold electron microscopy, TAR DNA-binding protein of 43 kDa (TDP-43) was localized to neuronal cytoplasmic (NCI) and intranuclear (NII) inclusions, as well as unmyelinated neurites, in frontotemporal lobar degeneration with ubiquitinated inclusions (FTLD-U), amyotrophic lateral sclerosis (ALS), Alzheimer's (AD), Pick's disease (PiD) and Lewy body disease (LBD). The TDP-43 immunoreactive structures were morphologically heterogeneous. The most common was characterized by bundles of 10-20 nm diameter straight filaments with electron dense granular material within NCI, NII and neurites. This type of pathology was found in FTLD-U, ALS and some cases of AD. Less often, inclusions in neuritic processes of FTLD-U and some cases of AD contained 10-17 nm diameter straight filaments without granular material. A final type of TDP-43 immunoreactivity was labeling of filaments and granular material associated with tau filaments in neurofibrillary tangles of AD and Pick bodies of PiD or alpha-synuclein filaments in Lewy bodies of LBD. The results suggest that TDP-43 is the primary component of the granulofilamentous inclusions in FTLD-U and ALS. Similar inclusions sometimes accompany filamentous aggregates composed of other abnormal proteins in AD, PiD and LBD.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}150{"query": "On 6 June 1968, Messerschmitt AG merged with the small civil engineering and civil aviation firm Bolkow, becoming Messerschmitt-Bolkow.", "pos": "The Battle of Munchengratz (German: Schlacht bei Munchengratz) or Battle of Mnichovo Hradiste (Czech: Bitva u Mnichova Hradiste) was fought near Mnichovo Hradiste, modern day Czech Republic, on 28 June 1866 during the Austro-Prussian War.", "neg": "Born on 16 November 1920 in Brunoy, near Paris, Jean Boulet was first hired in 1947 by the SNCASE, which would become Sud Aviation and then later the Division Helicopteres of the Societe Nationale Industrielle Aerospatiale.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}151{"query": "Denis Loginov (born 5 May 1985) is a Russian professional ice hockey forward currently playing for Ertis Pavlodar of Kazakhstan Vyschaya Liga.", "pos": "Calvin de Haan (born May 9, 1991) is a Canadian professional ice hockey defenceman currently playing for the New York Islanders of the National Hockey League (NHL).", "neg": "The Seattle Metropolitans were a professional ice hockey team based in Seattle, Washington which played in the Pacific Coast Hockey Association from 1915 to 1924.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}152{"query": "The expression of selenoproteins requires the translational recoding of the UGA stop codon to selenocysteine. In eukaryotes, this requires an RNA stem loop structure in the 3'-untranslated region, termed a selenocysteine insertion sequence (SECIS), and SECIS-binding protein 2 (SBP2). This study implicates SBP2 in dictating the hierarchy of selenoprotein expression, because it is the first to show that SBP2 distinguishes between SECIS elements in vitro. Using RNA electrophoretic mobility shift assays, we demonstrate that a naturally occurring mutation in SBP2, which correlates with abnormal thyroid hormone function in humans, lies within a novel, bipartite RNA-binding domain. This mutation alters the RNA binding affinity of SBP2 such that it no longer stably interacts with a subset of SECIS elements. Assays performed under competitive conditions to mimic intracellular conditions suggest that the differential affinity of SBP2 for various SECIS elements will determine the expression pattern of the selenoproteome. We hypothesize that the selective loss of a subset of selenoproteins, including some involved in thyroid hormone homeostasis, is responsible for the abnormal thyroid hormone metabolism previously observed in the affected individuals.", "pos": "The amino acid selenocysteine is encoded by UGA, usually a stop codon, thus requiring a specialized machinery to enable its incorporation into selenoproteins. The machinery comprises the tRNA(Sec), a 3'-UTR mRNA stem-loop termed SElenoCysteine Insertion Sequence (SECIS), which is mandatory for recoding UGA as a Sec codon, the SECIS Binding Protein 2 (SBP2), and other proteins. Little is known about the molecular mechanism and, in particular, when, where, and how the SECIS and SBP2 contact the ribosome. Previous work by others used the isolated SECIS RNA to address this question. Here, we developed a novel approach using instead engineered minimal selenoprotein mRNAs containing SECIS elements derivatized with photoreactive groups. By cross-linking experiments in rabbit reticulocyte lysate, new information could be gained about the SBP2 and SECIS contacts with components of the translation machinery at various translation steps. In particular, we found that SBP2 was bound only to the SECIS in 48S pre-initiation and 80S pretranslocation complexes. In the complex where the Sec-tRNA(Sec) was accommodated to the A site but transpeptidation was blocked, SBP2 bound the ribosome and possibly the SECIS element as well, and the SECIS had flexible contacts with the 60S ribosomal subunit involving several ribosomal proteins. Altogether, our findings led to broadening our understanding about the unique mechanism of selenocysteine incorporation in mammals.", "neg": "A mutation in the ubiquilin 2 gene (UBQLN2) was recently identified as a cause of X-linked amyotrophic lateral sclerosis (ALS)/frontotemporal dementia (FTD) and a major component of the inclusion bodies commonly found with a wide variety of ALS. ALS-linked mutations in UBQLN2 are clustered in a unique proline-X-X repeat region, reportedly leading to impairment of the ubiquitin proteasome system. However, the molecular properties of mutant UBQLN2 remain unclear. To gain insight into the pathogenesis of UBQLN2-linked ALS/FTD, we examined the biochemical and cellular characteristics of mutant UBQLN2 in vitro. UBQLN2 localized in Rab11-positive endosomal vesicles formed by the ALS-linked molecule optineurin (OPTN). These vesicles were ubiquitin- and p62-immunopositive and also co-localized with an initiator of the autophagic process, ULK1, after amino acid starvation. An ALS-linked mutation (E478G) in OPTN abolished vesicle formation. ALS-linked mutations in UBQLN2 additively enhanced UBQLN2 aggregation and formation of inclusion bodies, resulting in mislocation from OPTN vesicles. UBQLN2 was found to be a potent regulator of the levels of the FTD-linked secretory factor progranulin, possibly via the endosomal system, and ALS-linked mutations disturbed these functional consequences. This study demonstrates that ALS-linked mutations in both OPTN and UBQLN2 interfere with the constitution of specific endosomal vesicles, suggesting that the vesicles are involved in protein homeostasis and that these proteins function in common pathological processes. These data suggest a novel disease spectrum and provide new pathological insights into OPTN and UBQLN2, enhancing our understanding of the molecular basis of ALS/FTD.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}153{"query": "The Toyota MR2 is a two-seat, mid-engined, rear-wheel-drive sports car manufactured in Japan and marketed globally by Toyota from 1984-2007 over three generations:", "pos": "The DeLorean DMC-12 (commonly referred to simply as the DeLorean as it was the only model ever produced by the company) is a sports car manufactured by John DeLorean's DeLorean Motor Company for the American market from 1981--83.", "neg": "Ptolemy III Euergetes (Greek: , Ptolemaios Euergetes, reigned 246--222 BC) was the third king of the Ptolemaic dynasty in Egypt.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}154{"query": "An ionic bond is the force of attraction that holds together positive and negative ions. It forms when atoms of a metallic element give up electrons to atoms of a nonmetallic element. Figure 7.3 shows how this happens. In row 1 of Figure 7.3, an atom of sodium donates an electron to an atom of chlorine (Cl). By losing an electron, the sodium atom becomes a sodium ion. It now has one less electron than protons, giving it a charge of +1. Positive ions such as sodium are given the same name as the element. The chemical symbol has a plus sign to distinguish the ion from an atom of the element. The symbol for a sodium ion is Na+ . By gaining an electron, the chlorine atom becomes a chloride ion. It now has one more electron than protons, giving it a charge of -1. Negative ions are named by adding the suffix ide to the first part of the element name. The symbol for chloride is Cl . Sodium and chloride ions have equal but opposite charges. Opposites attract, so sodium and chloride ions attract each other. They cling together in a strong ionic bond. You can see this in row 2 of Figure 7.3. Brackets separate the ions in the diagram to show that the ions in the compound do not share electrons. You can see animations of sodium chloride forming at these URLs: [Link]~acarpi/NSC/salt.htm Ionic bonds form only between metals and nonmetals. Metals \"want\" to give up electrons, and nonmetals \"want\" to gain electrons. Find sodium (Na) in Figure 7.4. Sodium is an alkali metal in group 1. Like other group 1 elements, it has just one valence electron. If sodium loses that one electron, it will have a full outer energy level. Now find fluorine (F) in Figure 7.4. Fluorine is a halogen in group 17. It has seven valence electrons. If fluorine gains one electron, it will have a full outer energy level. After sodium gives up its valence electron to fluorine, both atoms have a more stable arrangement of electrons. It takes energy to remove valence electrons from an atom. The force of attraction between the negative electrons and positive nucleus must be overcome. The amount of energy needed depends on the element. Less energy is needed to remove just one or a few electrons than many. This explains why sodium and other alkali metals form positive ions so easily. Less energy is also needed to remove electrons from larger atoms in the same group. For example, in group 1, it takes less energy to remove an electron from francium (Fr) at the bottom of the group than from lithium (Li) at the top of the group (see Figure 7.4). In bigger atoms, valence electrons are farther from the nucleus. As a result, the force of attraction between the electrons and nucleus is weaker. What happens when an atom gains an electron and becomes a negative ion? Energy is released. Halogens release the most energy when they form ions. As a result, they are very reactive. Ionic compounds contain ions of metals and nonmetals held together by ionic bonds. Ionic compounds do not form molecules. Instead, many positive and negative ions bond together to form a structure called a crystal. You can see an example of a crystal in Figure 7.5. It shows the ionic compound sodium chloride. Positive sodium ions (Na+ ) alternate with negative chloride ions (Cl ). The oppositely charged ions are strongly attracted to each other. Helpful Hints Naming Ionic Compounds Ionic compounds are named for their positive and negative ions. The name of the positive The crystal structure of ionic compounds is strong and rigid. It takes a lot of energy to break all those strong ionic bonds. As a result, ionic compounds are solids with high melting and boiling points (see Table 7.2). The rigid crystals are brittle and more likely to break than bend when struck. As a result, ionic crystals tend to shatter. You can learn more about the properties of ionic compounds by watching the video at this URL: MEDIA Click image to the left or use the URL below. URL:", "pos": "Electrons are one of three main types of particles that make up atoms. The other two types are protons and neutrons. Unlike protons and neutrons, which consist of smaller, simpler particles, electrons are fundamental particles that do not consist of smaller particles. They are a type of fundamental particles called leptons. All leptons have an electric charge of -1 or 0. Click image to the left or use the URL below. URL: Electrons are extremely small. The mass of an electron is only about 1/2000 the mass of a proton or neutron, so electrons contribute virtually nothing to the total mass of an atom. Electrons have an electric charge of -1, which is equal but opposite to the charge of proton, which is +1. All atoms have the same number of electrons as protons, so the positive and negative charges cancel out, making atoms electrically neutral. Unlike protons and neutrons, which are located inside the nucleus at the center of the atom, electrons are found outside the nucleus. Because opposite electric charges attract each other, negative electrons are attracted to the positive nucleus. This force of attraction keeps electrons constantly moving through the otherwise empty space around the nucleus. The Figure shown 1.1 is a common way to represent the structure of an atom. It shows the electron as a particle orbiting the nucleus, similar to the way that planets orbit the sun. The atomic model above is useful for some purposes, but its too simple when it comes to the location of electrons. In reality, its impossible to say what path an electron will follow. Instead, its only possible to describe the chances of finding an electron in a certain region around the nucleus. The region where an electron is most likely to be is called an orbital. Each orbital can have at most two electrons. Some orbitals, called S orbitals, are shaped like spheres, with the nucleus in the center. An S orbital is pictured in Figure 1.2. Where the dots are denser, the chance of finding an electron is greater. Also pictured in Figure 1.2 is a P orbital. P orbitals are shaped like dumbbells, with the nucleus in the pinched part of the dumbbell. Click image to the left or use the URL below. URL: Q: How many electrons can there be in each type of orbital shown above? A: There can be a maximum of two electrons in any orbital, regardless of its shape. Q: Where is the nucleus in each orbital? A: The nucleus is at the center of each orbital. It is in the middle of the sphere in the S orbital and in the pinched part of the P orbital. Electrons are located at fixed distances from the nucleus, called energy levels. You can see the first three energy levels in the Figure 1.3. The diagram also shows the maximum possible number of electrons at each energy level. Electrons at lower energy levels, which are closer to the nucleus, have less energy. At the lowest energy level, which has the least energy, there is just one orbital, so this energy level has a maximum of two electrons. Only when a lower energy level is full are electrons added to the next higher energy level. Electrons at higher energy levels, which are farther from the nucleus, have more energy. They also have more orbitals and greater possible numbers of electrons. Electrons at the outermost energy level of an atom are called valence electrons. They determine many of the properties of an element. Thats because these electrons are involved in chemical reactions with other atoms. Atoms may share or transfer valence electrons. Shared electrons bind atoms together to form chemical compounds. Q: If an atom has 12 electrons, how will they be distributed in energy levels? A: The atom will have two electrons at the first energy level, eight at the second energy level, and the remaining two at the third energy level. Q: Sometimes, an electron jumps from one energy level to another. How do you think this happens? A: To change energy levels, an electron must either gain or lose energy. Thats because electrons at higher energy levels have more energy", "neg": "In a chemical formula, the elements in a compound are represented by their chemical symbols, and the ratio of different elements is represented by subscripts. Consider the compound water as an example. Each water molecule contains two hydrogen atoms and one oxygen atom. Therefore, the chemical formula for water is: H2 O The subscript 2 after the H shows that there are two atoms of hydrogen in the molecule. The O for oxygen has no subscript. When there is just one atom of an element in a molecule, no subscript is used in the chemical formula. The Table 1.1 shows four examples of compounds and their chemical formulas. The first two compounds are ionic compounds, and the second two are covalent compounds. Each formula shows the ratio of ions or atoms that make up the compound. Name of Compound Type of Compound Sodium chloride ionic Calcium iodide ionic Hydrogen peroxide covalent Carbon dioxide covalent Ratio of Ions or Atoms of Each Element 1 sodium ion (Na+ ) 1 chloride ion (Cl ) 1 calcium ion (Ca2+ ) 2 io- dide ions (I ) 2 hydrogen atoms (H) 2 oxygen atoms (O) 1 carbon atom (C) 2 oxy- gen atoms (O) Chemical Formulas NaCl CaI2 H2 O2 CO2 There is a different rule for writing the chemical formula for each type of compound. Ionic compounds are compounds in which positive metal ions and negative nonmetal ions are joined by ionic bonds. In these compounds, the chemical symbol for the positive metal ion is written first, followed by the symbol for the negative nonmetal ion. Click image to the left or use the URL below. URL: Q: The ionic compound lithium fluoride consists of a ratio of one lithium ion (Li+ ) to one fluoride ion (F ). What is the chemical formula for this compound? A: The chemical formula is LiF. Covalent compounds are compounds in which nonmetals are joined by covalent bonds. In these compounds, the element that is farther to the left in the periodic table is written first, followed by the element that is farther to the right. If both elements are in the same group of the periodic table, the one with the higher period number is written first. Click image to the left or use the URL below. URL: Q: A molecule of the covalent compound nitrogen dioxide consists of one nitrogen atom (N) and two oxygen atoms (O). What is the chemical formula for this compound? A: The chemical formula is NO2 .", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}155{"query": "Angelo Esposito (born February 20, 1989) is a Canadian professional ice hockey player who is currently playing with SG Cortina of the Italian Serie A and who was drafted by the Pittsburgh Penguins in the first round (twentieth overall) of the 2007 NHL Entry Draft.", "pos": "Marcus Foligno (born August 10, 1991) is an American-Canadian professional ice hockey player, who plays for the Buffalo Sabres of the National Hockey League (NHL).", "neg": "The Titan mine is one of the largest titanium mines in Canada.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}156{"query": "HIV, or human immunodeficiency virus, causes AIDS. AIDS stands for \"acquired immune deficiency syndrome.\" It is a condition that causes death and does not have a known cure. AIDS usually develops 10 to 15 years after a person is first infected with HIV. The development of AIDS can be delayed with proper medicines. The delay can be well over 20 years with the right medicines. Today, individuals who acquire HIV after 50 years of age can expect to reach an average human life span. HIV spreads through contact between an infected persons body fluids and another persons bloodstream or mucus membranes, which are found in the mouth, nose, and genital areas. Body fluids that may contain HIV are blood, semen, vaginal fluid, and breast milk. The virus can spread through sexual contact or shared drug needles. It can also spread from an infected mother to her baby during childbirth or breastfeeding. Saliva can carry the HIV virus, but it wont spread it, unless the saliva gets into the bloodstream. Other body fluids such as urine and sweat do not contain the virus. HIV does not spread in any fluid in which the host cells cannot survive. Some people think they can become infected with HIV by donating blood or receiving donated blood. This is not true. The needles used to draw blood for donations are always new. Therefore, they cannot spread the virus. Donated blood is also tested to make sure it is does not contain HIV. HIV is not transmitted by day-to-day contact in the workplace, schools, or social settings. HIV is not transmitted through shaking hands, hugging, or a casual kiss. You cannot become infected from a toilet seat, a drinking fountain, a door knob, dishes, drinking glasses, food, or pets. How does an HIV infection develop into AIDS? HIV destroys white blood cells called helper T cells. The cells are produced by the immune system. This is the body system that fights infections and other diseases. HIV invades helper T cells and uses them to produce more virus particles ( Figure 1.1). Then, the virus kills the helper T cells. As the number of viruses in the blood rises, the number of helper T cells falls. Without helper T cells, the immune system is unable to protect the body. The infected person cannot fight infections and other diseases because they do not have T cells. This is why people do not die from HIV. Instead, they die from another illness, like the common cold, that they cannot fight because they do not have helper T cells. Medications can slow down the increase of viruses in the blood. But the medications cannot remove the viruses from the body. At present, there is no cure for HIV infection. A vaccine against HIV could stop this disease, and such a vaccine is in development, though it could take many years before it can be given to prevent this virus. AIDS is not really a single disease. It is a set of symptoms and other diseases. It results from years of damage to the immune system by HIV. AIDS occurs when helper T cells fall to a very low level, making it difficult for the affected person to fight various diseases and other infections. These people develop infections or cancers that people with a healthy immune systems can easily resist. These diseases are usually the cause of death of people with AIDS. The first known cases of AIDS occurred in 1981. Since then, AIDS has led to the deaths of more than 35 million people worldwide. Many of them were children. The greatest number of deaths occurred in Africa. It is also where medications to control HIV are least available. There are currently more people infected with HIV in Africa than any other part of the world. Well over 30 million people are living with HIV worldwide.", "pos": "A sexually transmitted infection (STI) is an infection that spreads through sexual contact. STIs are caused by pathogens, a living thing or virus that causes infection. The pathogens enter the body through the reproductive organs. Many STIs also spread through body fluids, such as blood. For example, a shared tattoo needle is one way an STI could spread. Some STIs can also spread from a mother to her baby during childbirth. STIs are more common in teens and young adults than in older people. One reason is that young people are more likely to take risks. They also may not know how STIs spread. They are likely to believe myths about STIs ( Table Myth If you are sexually active with just one person, you cant get STIs. If you dont have any symptoms, then you dont have an STI. Getting STIs is no big deal, because STIs can be cured with medicine. Fact The only way to avoid the risk of STIs is to practice abstinence from sexual activity. Many STIs do not cause symptoms, especially in fe- males. Only some STIs can be cured with medicine; other STIs cannot be cured. Most STIs are caused by bacteria or viruses. STIs caused by bacteria usually can be cured with drugs called antibiotics. But antibiotics are not effective against viruses. Therefore, STIs caused by viruses are not treated with antibiotics. Other drugs may be used to help control the symptoms of viral STIs, but they cannot be cured. Once you have a viral STI, you are usually infected for life. In the U.S., chlamydia is the most common STI caused by bacteria. Females are more likely than males to develop the infection. Rates of chlamydia among U.S. females in 2006 are shown below ( Figure 1.1). Rates were much higher in teens and young women than in other age groups. Chlamydia may cause a burning feeling during urination. It may also cause a discharge (leaking of fluids) from the vagina or penis. But in many cases it causes no symptoms. As a result, people do not know they are infected, so they dont go to the doctor for help. If chlamydia goes untreated, it may cause more serious problems in females. It may cause infections of the uterus, fallopian tubes, or ovaries. These infections may leave a woman unable to have children. Gonorrhea is another common STI. Gonorrhea may cause pain during urination. It may also cause a discharge from the vagina or penis. On the other hand, some people with gonorrhea have no symptoms. As a result, they dont seek treatment. Without treatment, gonorrhea may lead to infection of other reproductive organs. This can happen in males as well as females. Syphilis is a very serious STI. Luckily, it is less common than chlamydia or gonorrhea. Syphilis usually begins with a small sore on the genitals. This is followed a few months later by a rash and flu-like symptoms. If syphilis is not treated, it may damage the heart, brain, and other organs. It can even cause death. Genital warts are an STI caused by human papilloma virus, or HPV. They are one of the most common STIs in teenagers. HPV infections cannot be cured. But a new vaccine called Gardasil can prevent most HPV infections in females. Many doctors recommend that females between the ages of 9 and 26 years receive the vaccine. Preventing HPV infections in females is important because HPV can also cause cancer of the cervix. A related herpes virus causes cold sores on the lips ( Figure 1.2). Both viruses cause painful blisters. In the case of genital herpes, the blisters are on the penis or around the vaginal opening. The blisters go away on their own, but the virus remains in the body. The blisters may come back repeatedly, especially when a person is under stress. There is no cure for genital herpes. But drugs can help prevent or shorten outbreaks. Researchers are trying to find a vaccine to prevent genital herpes. Hepatitis B is a disease of the liver. It is caused by a virus called hepatitis B, which can be passed through sexual activity", "neg": "The immune system usually protects you from pathogens and other causes of disease. When the immune system is working properly, it keeps you from getting sick. But the immune system is like any other system of the body. It can break down or develop diseases. AIDS is an infectious disease of the immune system caused by a virus. Some diseases of the immune system are noninfectious. They include autoimmune diseases and allergies. Does it make sense for an immune system to attack the cells it is meant to protect? No, but an immune system that does not function properly will attack its own cells. An autoimmune disease is a disease in which the immune system attacks the bodys own cells. One example is type 1 diabetes. In this disease, the immune system attacks cells of the pancreas. Other examples are multiple sclerosis and rheumatoid arthritis. In multiple sclerosis, the immune system attacks nerve cells. This causes weakness and pain. In rheumatoid arthritis, the immune system attacks the cells of joints. This causes joint damage and pain. Autoimmune diseases cannot be cured. But they can be helped with medicines that weaken the immune systems attack on normal cells. Other autoimmune diseases include celiac disease (damages to the small intestine), inflam- matory bowel disease (damage to the digestive tract), psoriasis (damage to the skin), and lupus (damage to the joints, skin, kidneys, heart, and lungs). An allergy occurs when the immune system attacks a harmless substance that enters the body from the outside. A substance that causes an allergy is called an allergen. It is the immune system, not the allergen, that causes the symptoms of an allergy. Did you ever hear of hay fever? Its not really a fever at all. Its an allergy to plant pollens. People with this type of allergy have symptoms such as watery eyes, sneezing, and a runny nose. A common cause of hay fever is the pollen of ragweed. Many people are also allergic to poison ivy ( Figure 1.2). Skin contact with poison ivy leads to an itchy rash in people who are allergic to the plant. Ragweed is a common roadside weed found throughout the United States. Many people are allergic to its pollen. Some people are allergic to certain foods. Nuts and shellfish are common causes of food allergies. Other common causes of allergies include: Drugs, such as penicillin. Mold. Dust. The dead skin cells of dogs and cats, called dander. Stings of wasps and bees. Most allergies can be treated with medicines. Medicines used to treat allergies include antihistamines and corticos- teroids. These medicines help control the immune system when it attacks an allergen. Sometimes, allergies cause severe symptoms, a condition known as anaphylaxis. For example, they may cause the throat to swell so it is hard to breathe. Severe allergies may be life threatening. They require emergency medical care.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}157{"query": "Chronic myeloid leukemia (CML) is characterized by the Philadelphia translocation that fuses BCR sequences from chromosome 22 upstream of the ABL gene on chromosome 9. The chimerical Bcr-Abl protein expressed by CML cells has constitutive tyrosine kinase activity, which is essential for the pathogenesis of the disease. Imatinib, an ATP-competitive selective inhibitor of Bcr-Abl, has unprecedented efficacy for the treatment of CML. Most patients with early stage disease achieve durable complete hematological and complete cytogenetic remissions, with minimal toxicity. In contrast, responses are less stable in patients with advanced CML. This review highlights the pathogenesis of CML, its clinical features, and the development of imatinib as a specific molecularly targeted therapy. Aspects of disease monitoring and side effects are covered as well as resistance to imatinib and strategies to overcome resistance, such as alternative signal transduction inhibitors and drug combinations. Perspectives for further development are also discussed.", "pos": "Chronic myeloid leukemia (CML) is a progressive and often fatal myeloproliferative neoplasm. The hallmark of CML is an acquired chromosomal translocation known as the Philadelphia chromosome (Ph), which results in the synthesis of the breakpoint cluster region-Abelson murine leukemia (BCR-ABL) fusion oncoprotein, a constitutively active tyrosine kinase. The introduction of imatinib, a tyrosine kinase inhibitor (TKI) that is specific for BCR-ABL, was a major breakthrough in CML therapy. Although most patients respond to first-line imatinib therapy, some experience loss of response (resistance) or require treatment discontinuation because of toxicity (intolerance). For patients with CML, failure on standard-dose imatinib therapy (400 mg daily), imatinib dose escalation (600-800 mg daily) is a second-line option. However, high-dose imatinib is not an appropriate approach for patients who experience drug toxicity, and there remain questions over the durability of responses achieved with this strategy. Alternative second-line options include the TKIs dasatinib and nilotinib. A substantial amount of long-term data for these agents is available. Although both are potent and specific BCR-ABL TKIs, dasatinib and nilotinib exhibit unique pharmacologic profiles and response patterns relative to different patient characteristics, such as disease stage and BCR-ABL mutation status. To optimize therapeutic benefit, clinicians should select treatment based on each patient's historic response, adverse-event tolerance, and risk factors.", "neg": "Differentiation of cancer stem cells (CSCs) into cancer cells causes increased sensitivity to chemotherapeutic agents. Although inhibition of mammalian target of rapamycin (mTOR) leads to CSC survival, the effect of branched chain amino acids (BCAAs), an mTOR complex 1 (mTORC1) activator remains unknown. In this study, we examined the effects of BCAA on hepatocellular carcinoma (HCC) cells expressing a hepatic CSC marker, EpCAM. We examined the effects of BCAA and/or 5-fluorouracil (FU) on expression of EpCAM and other CSC-related markers, as well as cell proliferation in HCC cells and in a xenograft mouse model. We also characterized CSC-related and mTOR signal-related molecule expression and tumorigenicity in HCC cells with knockdown of Rictor or Raptor, or overexpression of constitutively active rheb (caRheb). mTOR signal-related molecule expression was also examined in BCAA-treated HCC cells. In-vitro BCAA reduced the frequency of EpCAM-positive cells and improved sensitivity to the anti-proliferative effect of 5-FU. Combined 5-FU and BCAA provided better antitumor efficacy than 5-FU alone in the xenograft model. Stimulation with high doses of BCAA activated mTORC1. Knockdown and overexpression experiments revealed that inhibition of mTOR complex 2 (mTORC2) or activation of mTORC1 led to decreased EpCAM expression and little or no tumorigenicity. BCAA may enhance the sensitivity to chemotherapy by reducing the population of cscs via the mTOR pathway. This result suggests the utility of BCAA in liver cancer therapy.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}158{"query": "Five characteristics are used to define life. All living things share these characteristics. All living things: 1. 2. 3. 4. 5. are made of one or more cells. need energy to stay alive. respond to stimuli in their environment. grow and reproduce. maintain a stable internal environment. Cells are the basic building blocks of life. They are like tiny factories where virtually all life processes take place. Some living things, like the bacteria in Figure 2.1, consist of just one cell. They are called single-celled organisms. You can see other single-celled organisms in Figure 2.2. Some living things are composed of a few to many trillions of cells. They are called multicellular organisms. Your body is composed of trillions of cells. Regardless of the type of organism, all living cells share certain basic structures. For example, all cells are enclosed by a membrane. The cell membrane separates the cell from its environment. It also controls what enters or leaves the cell. Everything you do takes energy. Energy is the ability to change or move matter. Whether its reading these words or running a sprint, it requires energy. In fact, it takes energy just to stay alive. Where do you get energy? You probably know the answer. You get energy from food. Figure {{ref|MS-LS-SE-02-03-Food|below}] shows some healthy foods that can provide you with energy. Just like you, other living things need a source of energy. But they may use a different source. Organisms may be grouped on the basis of the source of energy they use. In which group do you belong? Producers such as the tree in Figure 2.1 use sunlight for energy to produce their own food. The process is called photosynthesis, and the food is sugar. Plants and other organisms use this food for energy. Consumers such as the raccoon in Figure 2.1 eat plantsor other consumers that eat plantsas a source of energy. Some consumers such as the mushroom in Figure 2.1 get their energy from dead organic matter. For example, they might consume dead leaves on a forest floor. When a living thing responds to its environment, it is responding to a stimulus. A stimulus (stimuli, plural) is something in the environment that causes a reaction in an organism. The reaction a stimulus produces is called a response. Imagine how you would respond to the following stimuli: Youre about to cross a street when the walk light turns red. You hear a smoke alarm go off in the kitchen. You step on an upturned tack with a bare foot. You smell the aroma of your favorite food. You taste something really sour. It doesnt take much imagination to realize that responding appropriately to such stimuli might help keep you safe. It might even help you survive. Like you, all other living things sense and respond to stimuli in their environment. In general, their responses help them survive or reproduce. Watch this amazing time-lapse video to see how a plant responds to the stimuli of light and gravity as it grows. Why do you think it is important for a plant to respond appropriately to these stimuli for proper growth? MEDIA Click image to the left or use the URL below. URL: Like plants, all living things have the capacity for growth. The ducklings in Figure 2.4 have a lot of growing to do to catch up in size to their mother. Multicellular organisms like ducks grow by increasing the size and number of their cells. Single-celled organisms just grow in size. As the ducklings grow, they will develop and mature into adults. By adulthood, they will be able to reproduce. Reproduction is the production of offspring. The ability to reproduce is another characteristic of living things. Many organisms reproduce sexually. In sexual reproduction, parents of different sexes mate to produce offspring. The offspring have some combination of the traits of the two parents. Ducks are examples of sexually reproducing organisms. Other organisms reproduce asexually. In asexual reproduction, a single parent can produce offspring alone. For example, a bacterial cell reproduces by dividing into two daughter cells.", "pos": "The main chemical components of living organisms are known as organic compounds. Organic compounds are molecules built around the element carbon (C). Living things are made up of very large molecules. These large molecules are called macromolecules because macro means large; they are made by smaller molecules bonding together. Our body gets these smaller molecules, the \"building blocks\" or monomers, of organic molecules from the food we eat. Which organic molecules do you recognize from the list below? The four main types of macromolecules found in living organisms, shown in Table 1.1, are: 1. 2. 3. 4. Proteins. Carbohydrates. Lipids. Nucleic Acids. Proteins C, H, O, N, S Enzymes, muscle fibers, antibodies Elements Examples Monomer building molecule) (small block Amino acids Carbohydrates C, H, O Sugar, glucose, starch, glycogen, cellulose Monosaccharides (simple sugars) Lipids C, H, O, P Fats, oils, waxes, steroids, phospho- lipids in membranes Often include fatty acids Nucleic Acids C, H, O, P, N DNA, RNA, ATP Nucleotides Carbohydrates are sugars, or long chains of sugars. An important role of carbohydrates is to store energy. Glucose ( Figure 1.1) is an important simple sugar molecule with the chemical formula C6 H12 O6 . Simple sugars are known as monosaccharides. Carbohydrates also include long chains of connected sugar molecules. These long chains often consist of hundreds or thousands of monosaccharides bonded together to form polysaccharides. Plants store sugar in polysaccharides called starch. Animals store sugar in polysaccharides called glycogen. You get the carbohydrates you need for energy from eating carbohydrate-rich foods, including fruits and vegetables, as well as grains, such as bread, rice, or corn. A molecule of glucose, a type of carbohy- drate. Proteins are molecules that have many different functions in living things. All proteins are made of monomers called amino acids ( Figure 1.2) that connect together like beads on a necklace ( Figure 1.3). There are only 20 common amino acids needed to build proteins. These amino acids form in thousands of different combinations, making about 100,000 or more unique proteins in humans. Proteins can differ in both the number and order of amino acids. It is the number and order of amino acids that determines the shape of the protein, and it is the shape (structure) of the protein that determines the unique function of the protein. Small proteins have just a few hundred amino acids. The largest proteins have more than 25,000 amino acids. This model shows the general structure of all amino acids. Only the side chain, R, varies from one amino acid to another. KEY: H = hydrogen, N = nitrogen, C = carbon, O = oxygen, R = variable side chain. Many important molecules in your body are proteins. Examples include enzymes, antibodies, and muscle fiber. Enzymes are a type of protein that speed up chemical reactions. They are known as \"biological catalysts.\" For example, your stomach would not be able to break down food if it did not have special enzymes to speed up the rate of digestion. Antibodies that protect you against disease are proteins. Muscle fiber is mostly protein ( Figure 1.4). Muscle fibers are made mostly of protein. Its important for you and other animals to eat food with protein, because we cannot make certain amino acids on our own. You can get proteins from plant sources, such as beans, and from animal sources, like milk or meat. When you eat food with protein, your body breaks the proteins down into individual amino acids and uses them to build new proteins. You really are what you eat! Have you ever tried to put oil in water? They dont mix. Oil is a type of lipid. Lipids are molecules such as fats, oils, and waxes. The most common lipids in your diet are probably fats and oils. Fats are solid at room temperature, whereas oils are fluid. Animals use fats for long-term energy storage and to keep warm. Plants use oils for long- term energy storage. When preparing food", "neg": "The chemical elements and water that are needed by living things keep recycling on Earth. They pass back and forth through biotic and abiotic components of ecosystems. Thats why their cycles are called biogeochemical cycles. For example, a chemical element or water might move from organisms (bio) to the atmosphere or ocean (geo) and back to organisms again. Elements or water may be held for various periods of time in different parts of a biogeochemical cycle. An exchange pool is part of a cycle that holds a substance for a short period of time. For example, the atmosphere is an exchange pool for water. It usually holds water (as water vapor) for just a few days. A reservoir is part of a cycle that holds a substance for a long period of time. For example, the ocean is a reservoir for water. It may hold water for thousands of years. The rest of this lesson describes three biogeochemical cycles: water cycle, carbon cycle, and nitrogen cycle. Water is an extremely important aspect of every ecosystem. Life cant exist without water. Most organisms contain a large amount of water, and many live in water. Therefore, the water cycle is essential to life on Earth. Water on Earth is billions of years old. However, individual water molecules keep moving through the water cycle. The water cycle is a global cycle. It takes place on, above, and below Earths surface, as shown in Figure 24.7. During the water cycle, water occurs in three different states: gas (water vapor), liquid (water), and solid (ice). Many processes are involved as water changes state to move through the cycle. Watch this video for an excellent visual introduction to the water cycle: . MEDIA Click image to the left or use the URL below. URL: Water changes to a gas by three different processes called evaporation, sublimation, and transpiration. Evaporation takes place when water on Earths surface changes to water vapor. The sun heats the water and gives water molecules enough energy to escape into the atmosphere. Most evaporation occurs from the surface of the ocean. Sublimation takes place when snow and ice on Earths surface change directly to water vapor without first melting to form liquid water. This also happens because of heat from the sun. Transpiration takes place when plants release water vapor through pores in their leaves called stomata. Rising air currents carry water vapor into the atmosphere. As the water vapor rises in the atmosphere, it cools and condenses. Condensation is the process in which water vapor changes to tiny droplets of liquid water. The water droplets may form clouds. If the droplets get big enough, they fall as precipitation. Precipitation is any form of water that falls from the atmosphere. It includes rain, snow, sleet, hail, and freezing rain. Most precipitation falls into the ocean. Eventually, this water evaporates again and repeats the water cycle. Some frozen precipitation becomes part of ice caps and glaciers. These masses of ice can store frozen water for hundreds of years or even longer. Condensation may also form fog or dew. Some living things, like the lizard in Figure 24.8, depend directly on these sources of liquid water. Precipitation that falls on land may flow over the surface of the ground. This water is called runoff. It may eventually flow into a body of water. Some precipitation that falls on land soaks into the ground. This water becomes groundwater. Groundwater may seep out of the ground at a spring or into a body of water such as the ocean. Some groundwater is taken up by plant roots. Some may flow deeper underground to an aquifer. An aquifer is an underground layer of rock that stores water. Water may be stored in an aquifer for thousands of years. The element carbon is the basis of all life on Earth. Biochemical compounds consist of chains of carbon atoms and just a few other elements. Like water, carbon is constantly recycled through the biotic and abiotic factors of ecosystems. The carbon cycle includes carbon in sedimentary rocks and fossil fuels under the ground, the ocean, the atmosphere, and living things", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}159{"query": "In the county, the population was spread out with 23.5% under the age of 18, 7.8% from 18 to 24, 28.5% from 25 to 44, 25.9% from 45 to 64, and 14.2% who were 65 years of age or older. The median age was 40 years. For every 100 females, there were 93.8 males. For every 100 females age 18 and over, there were 90.5 males.", "pos": "In the county, the population was spread out with 23.20% under the age of 18, 7.70% from 18 to 24, 27.00% from 25 to 44, 28.00% from 45 to 64, and 14.10% who were 65 years of age or older. The median age was 40 years. For every 100 females, there were 97.00 males. For every 100 females age 18 and over, there were 96.40 males.", "neg": "As of the census of 2000, there were 35,100 people, 12,759 households, and 9,071 families residing in the county. The population density was 59 people per square mile (23/km). There were 15,035 housing units at an average density of 25 per square mile (10/km). The racial makeup of the county was 85.8% Race (United States Census), 3.9% Race (United States Census) or Race (United States Census), 1.8% Race (United States Census), 1.0% Race (United States Census), 0.1% Race (United States Census), 5.0% from Race (United States Census), and 2.4% from two or more races. 8.9% of the population were Race (United States Census) or Race (United States Census) of any race. 14.9% were of German people, 12.6% English people, 11.7% Irish people, 8.8% Italian people and 7.3% United States ancestry according to Census 2000. 93.1% spoke English language and 5.1% Spanish language as their first language.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}160{"query": "Excessive neointima formation often occurs after arterial injury. Interleukin-1 (IL-1) is a potent pleiotropic cytokine that has been shown to regulate neointimal proliferation. We investigated the effects of the IL-1 modulator gevokizumab in a rat carotid denudation model. Sprague-Dawley rats were subjected to balloon denudation of the right carotid artery and were then randomized to receive a single subcutaneous infusion immediately after balloon injury of saline (control group, n=13) or gevokizumab (gevokizumab groups, n=15 in each group: 1, 10 and 50mg/kg). We evaluated the treatment effects on carotid intima-media thickness (IMT) using ultrasonography, on endothelial regrowth using Evans Blue staining and on inflammatory response using histology. We also assessed the effects of IL-1 and gevokizumab on human umbilical vein endothelial cells (HUVEC) and rat smooth muscle cells. We found that carotid IMT, in the proximal part of the denuded artery at day 28, was decreased by gevokizumab 1mg/kg compared with controls. Neointima area and the intima/media area ratio were both reduced in the gevokizumab 1 mg/kg-treated group. Gevokizumab at the 1mg/kg dose also improved endothelial regrowth. No effect was observed with gevokizumab 10 or 50mg/kg. Gevokizumab also decreased the inflammatory effect of IL-1 in invitro cell experiments and protected HUVECs from IL-1's deleterious effects on cell migration, apoptosis and proliferation. A single administration of gevokizumab 1mg/kg improves endothelial regrowth and reduces neointima formation in rats following carotid denudation, at least in part through its beneficial effects on endothelial cells.", "pos": "Interleukin-1 (IL-1) is a proinflammatory cytokine that is implicated in many autoinflammatory disorders, but is also important in defense against pathogens. Thus, there is a need to safely and effectively modulate IL-1 activity to reduce pathology while maintaining function. Gevokizumab is a potent anti-IL-1 antibody being developed as a treatment for diseases in which IL-1 has been associated with pathogenesis. Previous data indicated that gevokizumab negatively modulates IL-1 signaling through an allosteric mechanism. Because IL-1 signaling is a complex, dynamic process involving multiple components, it is important to understand the kinetics of IL-1 signaling and the impact of gevokizumab on this process. In the present study, we measured the impact of gevokizumab on the IL-1 system using Schild analysis and surface plasmon resonance studies, both of which demonstrated that gevokizumab decreases the binding affinity of IL-1 for the IL-1 receptor type I (IL-1RI) signaling receptor, but not the IL-1 counter-regulatory decoy receptor (IL-1 receptor type II). Gevokizumab inhibits both the binding of IL-1 to IL-1RI and the subsequent recruitment of IL-1 accessory protein primarily by reducing the association rates of these interactions. Based on this information and recently published structural data, we propose that gevokizumab decreases the association rate for binding of IL-1 to its receptor by altering the electrostatic surface potential of IL-1, thus reducing the contribution of electrostatic steering to the rapid association rate. These data indicate, therefore, that gevokizumab is a unique inhibitor of IL-1 signaling that may offer an alternative to current therapies for IL-1-associated autoinflammatory diseases.", "neg": "Ghrelin exhibits its biological effect through binding to the growth hormone secretagogue 1a receptor (GHS-R1a). Recently, it has been reported that ghrelin has an anti-apoptotic effect in several cell types. However, the molecule mechanisms underlying the anti-apoptotic effect of ghrelin remain poorly understood. In this study, we investigated the intracellular mechanisms responsible for anti-apoptotic effect of ghrelin on human umbilical vein endothelial cells (HUVEC). Treatment of HUVEC with ghrelin inhibited high glucose-induced cell apoptosis. Ghrelin stimulated the rapid phosphorylation of mammalian target of rapamycin (mTOR), P70S6K and S6. The GHS-R1a-specific antagonist [D-Lys3]-GHRP-6 abolished the anti-apoptotic effect and inhibited the activation of mTOR, P70S6K, S6 induced by ghrelin. Pretreatment of cells with specific inhibitor of mTOR blocked the anti-apoptotic effect of ghrelin. In addition, ghrelin protected HUVECs against high glucose induced apoptosis by increasing Bcl-2/Bax ratio. Taken together, our results demonstrate that ghrelin produces a protective effect on HUVECs through activating GHS-R1a and mTOR/P70S6K signaling pathway mediates the effect of ghrelin. These observations suggest that ghrelin may act as a survival factor in preventing HUVECs apoptosis caused by high glucose.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}161{"query": "Claude Rains and James Stewart in Mr. Smith Goes to Washington Play media Trailer James Stewart and Jean Arthur in a taxicab The governor of an unnamed western state, Hubert \"Happy\" Hopper (Guy Kibbee), has to pick a replacement for recently deceased U.S. Senator Sam Foley. His corrupt political boss, Jim Taylor (Edward Arnold), pressures Hopper to choose his handpicked stooge, while popular committees want a reformer, Henry Hill. The governor's children want him to select Jefferson Smith (James Stewart), the head of the Boy Rangers. Unable to make up his mind between Taylor's stooge and the reformer, Hopper decides to flip a coin. When it lands on edge and next to a newspaper story on one of Smith's accomplishments he chooses Smith, calculating that his wholesome image will please the people while his naivete will make him easy to manipulate. Junior Senator Smith is taken under the wing of the publicly esteemed, but secretly crooked, Senator Joseph Paine (Claude Rains), who was Smith's late father's friend. Smith develops an immediate attraction to the senator's daughter, Susan (Astrid Allwyn). At Senator Paine's home, Smith has a conversation with Susan, fidgeting and bumbling, entranced by the young socialite. Smith's naive and honest nature allows the unforgiving Washington press to take advantage of him, quickly tarnishing Smith's reputation with ridiculous front page pictures and headlines branding him a bumpkin. To keep Smith busy, Paine suggests he propose a bill. With the help of his secretary, Clarissa Saunders (Jean Arthur), who was the aide to Smith's predecessor and had been around Washington and politics for years, Smith comes up with a bill to authorize a federal government loan to buy some land in his home state for a national boys' camp, to be paid back by youngsters across America. Donations pour in immediately. However, the proposed campsite is already part of a dam-building graft scheme included in an appropriations bill framed by the Taylor political machine and supported by Senator Paine. Unwilling to crucify the worshipful Smith so that their graft plan will go through, Paine tells Taylor he wants out, but Taylor reminds him that Paine is in power primarily through Taylor's influence. Through Paine, the machine in his state accuses Smith of trying to profit from his bill by producing fraudulent evidence that Smith already owns the land in question. Smith is too shocked by Paine's betrayal to defend himself, and runs away. Saunders, who looked down on Smith at first, but has come to believe in him, talks him into launching a filibuster to postpone the appropriations bill and prove his innocence on the Senate floor just before the vote to expel him. In his last chance to prove his innocence, he talks non-stop for about 24 hours, reaffirming the American ideals of freedom and disclosing the true motives of the dam scheme. Yet none of the Senators are convinced. The constituents try to rally around him, but the entrenched opposition is too powerful, and all attempts are crushed. Owing to the influence of Taylor's machine, newspapers and radio stations in Smith's home state, on Taylor's orders, refuse to report what Smith has to say and even distort the facts against the senator. An effort by the Boy Rangers to spread the news in support of Smith results in vicious attacks on the children by Taylor's minions. Although all hope seems lost, the senators begin to pay attention as Smith approaches utter exhaustion. Paine has one last card up his sleeve: he brings in bins of letters and telegrams from Smith's home state, purportedly from average people demanding his expulsion. Nearly broken by the news, Smith finds a small ray of hope in a friendly smile from the President of the Senate (Harry Carey). Smith vows to press on until people believe him, but immediately collapses in a faint. Overcome with guilt, Paine leaves the Senate chamber and attempts to commit suicide, but is stopped by other senators. When he is stopped, he bursts back into the Senate chamber, loudly confessing to the whole scheme;", "pos": "Set in the Australian outback in the 1880s, the movie follows the series of events following the horrific rape and murder of the Hopkins family, allegedly committed by the infamous Burns brothers gang.The film opens in a brothel during a violent gunfight between the police and Charlie Burns' (Guy Pearce) gang, which ends with the deaths of all of the gang members except for Charlie and his younger brother Mikey. Captain Stanley (Ray Winstone) proposes to Charlie: he and Mikey can go free of the crimes they have committed if Charlie kills his older brother, Arthur (Danny Huston). Arthur is a mercurial psychopath who has become something of a legend and is so vicious that the Aboriginal tribes refer to him as \"The Dog Man\" and both the police and the Aboriginals refuse to go near his camp. Captain Stanley muses that perhaps the bounty hunters will kill Arthur in time and then states his intention to civilize the harsh Australian wilderness by bringing Arthur to justice and using Mikey as leverage. Charlie has nine days to find and kill Arthur, or else Mikey will be hanged from the gallows on Christmas Day.We discover why Captain Stanley is intent on taming Australia: he has been forced to move there with his delicate wife, Martha Stanley (Emily Watson), and apparently wants to make it an appropriate place for them to live. The Stanleys were also friends of the Hopkins family, leading Martha to have nightmares about her dead friends and the unborn child one of them is revealed to have carried. Word spreads of Stanley's deal with Charlie, primarily from Stanley's corrupt subordinate, Sergeant Lawrence (Robert Morgan), causing disgust among the townspeople.Shortly thereafter, Eden Fletcher (David Wenham), for whom Captain Stanley works, orders that Mikey be given one hundred lashes as punishment for the rape and murder of the Hopkins family. Stanley is aghast at this, not only because he believes that Mikey is innocent and the flogging will surely kill him, but because it would also break his deal with Charlie and thus put him and his wife in grave danger. Stanley sends Sergeant Lawrence away with tracker Jacko (David Gulpillil) and other men to \"investigate\" the reported slaying of Dan O'Riley by a group of Aborigines. Captain Stanley attempts to defend Mikey by gunpoint from the bloodthirsty townspeople, but is overruled once Martha arrives, insisting on revenge for her dead friends. Mikey is then brutally flogged, and horrifically wounded. The formerly excited townspeople slowly become disgusted and Martha faints at the ghastly display. After 40 lashes, Mikey has collapsed and the whip is soaked with blood. Captain Stanley grabs the whip and throws it at Fletcher, staining his face and suit with blood, who in turn fires Stanley.Meanwhile, Charlie rides a great distance in search of Arthur, drinking and apparently reflecting on what he will do. Along the way, he encounters an inebriated old man named Jellon Lamb (John Hurt). In the course of conversation, Charlie realizes that Lamb is a bounty hunter in pursuit of the Burns brothers and knocks him out. Later on, after sleeping on a rock bed, Charlie awakes and, before he can gather what's going on, is speared in the chest by a group of Aboriginal men standing over him. Seconds later a gunshot is heard and the head of the man who threw the spear explodes. Charlie then passes out.Charlie wakes up in the camp of his brother Arthur, which is located in caves among desolate mountains. Arthur's gang consists of Samuel Stoat (Tom Budge), who shot the Aboriginal man who had speared Charlie; a woman named Queenie (Leah Purcell) who tends to Charlie's wound; and a muscular Aboriginal man called Two-Bob (Tom E. Lewis). As he recovers from his wounds, Charlie has several opportunities to kill his brother, but does not. Not too far away from Arthur's camp, Sergeant Lawrence and his men have found and butchered a group of Aborigines. Arthur and Two-Bob find Lawrence's group while they sleep, ostensibly to get a horse for Charlie, and proceed to kill Jacko and Sergeant Lawrence. Before Arthur stomps Lawrence", "neg": "The movie opens with James Reece (Jonathan Rhys Meyers) driving through the streets of Paris in a black SUV to work. Reece works in the American Embassy as an aide to Ambassador Bennington (Richard Durden), the U.S. Ambassador to France. Taking a delivery of some forms from the Ambassador's secretary, he goes over Bennington's itinerary for the next few days, centering around a major summit in which the U.S., France, and several other nations are preparing foreign aid to the African continent. Bennington shows that he is more absorbed right now in a chess game he's playing with Reece during all this time. Despite paying less attention to the board and the game than Bennington is, Reece quickly checkmates him to win.Reece receives a call from an unknown source (voiced by David Gasman) directing him to a silver BMW in the parking lot, excusing himself with a cover story to Bennington that he has to review the Summit's planned seating arrangement. Going to the parking lot, Reece opens a code-locked security compartment in the trunk of his SUV to reveal a firearm and several French license plates. He removes the license plate from the silver BMW and replaces it with one of the plates he has stowed away in his SUV. He then moves his SUV to another parking space and waits there, watching the silver BMW. He watches several men get into the vehicle, put a briefcase into its trunk, and drive away.Arriving home, Reece gets another call from the same source. Reece is in fact a CIA operative working in the Embassy as a cover. He does minor jobs for his superiors, and is eager to move up into Special Ops. His superior assures him he'll get his chance, but for right now he is needed to secure a hidden transmission chip in the French Foreign Minister's office during a meeting with Ambassador Bennington. Reece doesn't believe he was given a chip, but is told it's in his left jacket pocket. Checking his jacket, he finds the chip there.Sitting in his apartment, Reece examines the chip. He is interrupted by a knock on his door. It's his girlfriend, Caroline (Kasia Smutnak) (pronounced Cah-roll-een, the 'ine' being pronounced like in the word 'magazine'). Caroline kisses Reece and tells him she has a surprise. She sits him in a chair and makes him keep his back to her. He can hear her undressing and changing into a different outfit. When she tells him to look, his jaw drops at the sight of her wearing a sexy strapless dress. He thinks he recognizes the fabric, and Caroline tells him she made it out of their bedroom curtains-- Caroline is a clothing designer. The two of them quickly start to undress as they head into the bedroom to make out.Reece arrives the next day at the conference site to give Bennington a summary of what is intended to be discussed at the meeting. Bennington invites Reece to attend the meeting with him.During the meeting, Reece discreetly takes the chip (disguising it by putting a piece of gum in his mouth and offering another piece to the Minister's secretary) and tries to put it under the lampstand beside his seat, using his chewing gum as an adhesive. However, the gum fails to hold and twice it falls back to the floor in plain sight. Frustrated, and barely managing to keep the chip hidden, as a diversion Reece finally questions the Foreign Minister (Eric Godon) about his having several Goyas in his office. The Minister says he does, and offers to show them to Bennington, who is very interested in Goya art. As Bennington accompanies the Minister and secretary to see the Goyas, leaving Reece alone in the meeting room, Reece takes the stapler from the Minister's desk and staples the chip to the underside of the desk... but accidentally leaves the stapler open as he exits.Arriving home that evening, Reece is disquieted as the lights in the hallway go out. He finds what looks like a trail of blood leading to a door out onto the roof of the building. Grabbing a broom left in", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}162{"query": "The objective of this study was to analyze the expression levels of multiple components in the mammalian target of rapamycin (mTOR) signaling pathway in radical nephrectomy specimens from patients with metastatic renal-cell carcinoma (RCC) treated with mTOR inhibitors in order to identify factors predicting susceptibility to these agents. This study retrospectively included a total of 48 consecutive patients undergoing radical nephrectomy, who were diagnosed with metastatic RCC and subsequently treated with an mTOR inhibitor (everolimus or temsirolimus) as either first- or second-line systemic therapy. Expression levels of 5 molecular markers involved in the signaling pathway associated with mTOR, including PTEN, phosphorylated (p)-Akt, p-mTOR, p-p70 ribosomal S6 kinase, and p-4E-binding protein 1 (4E-BP1), were measured by immunohistochemical staining of primary RCC specimens. Of several factors examined, bone metastasis, liver metastasis, and the expression level of p-4E-BP1 were shown to have significant impacts on the response to the mTOR inhibitors. Progression-free survival (PFS) was significantly correlated with the expression levels of PTEN and p-4E-BP1 in addition to the presence of bone metastasis on univariate analysis. Of these significant factors, p-4E-BP1 expression and bone metastasis appeared to be independently associated with PFS on multivariate analysis. These findings suggest that it would be useful to consider the expression levels of potential molecular markers in the mTOR signaling pathway, particularly p-4E-BP1, as well as conventional clinical parameters when selecting patients with metastatic RCC who are likely to benefit from treatment with mTOR inhibitors.", "pos": "The mammalian target of rapamycin (mTOR) has been suggested as a target for radiosensitization. Given that radiotherapy is a primary treatment modality for glioblastoma (GBM) and that mTOR is often dysregulated in GBM, the goal of this study was to determine the effects of AZD2014, a dual mTORC1/2 inhibitor, on the radiosensitivity of GBM stem-like cells (GSCs). mTORC1 and mTORC2 activities were defined by immunoblot analysis. The effects of this mTOR inhibitor on the in vitro radiosensitivity of GSCs were determined using a clonogenic assay. DNA double strand breaks were evaluated according to H2AX foci. Orthotopic xenografts initiated from GSCs were used to define the in vivo response to AZD2014 and radiation. Exposure of GSCs to AZD2014 resulted in the inhibition of mTORC1 and 2 activities. Based on clonogenic survival analysis, addition of AZD2014 to culture media 1 hour before irradiation enhanced the radiosensitivity of CD133+ and CD15+ GSC cell lines. Whereas AZD2014 treatment had no effect on the initial level of H2AX foci, the dispersal of radiation-induced H2AX foci was significantly delayed. Finally, the combination of AZD2014 and radiation delivered to mice bearing GSC-initiated orthotopic xenografts significantly prolonged survival as compared with the individual treatments. These data indicate that AZD2014 enhances the radiosensitivity of GSCs both in vitro and under orthotopic in vivo conditions and suggest that this effect involves an inhibition of DNA repair. Moreover, these results suggest that this dual mTORC1/2 inhibitor may be a radiosensitizer applicable to GBM therapy.", "neg": "Interleukin-6 (IL-6) induces tumor growth, invasion, metastasis, and angiogenesis. Siltuximab (CNTO 328) is a chimeric, murine-human monoclonal antibody that specifically binds human IL-6 with high affinity. C-reactive protein (CRP) can be a pharmacodynamic (PD) marker of IL-6 bioactivity. Reductions in CRP may correlate with clinical activity and IL-6 bioactivity. Starting-dose selection for this study was based on a previous siltuximab study in multiple myeloma patients. Pharmacokinetic (PK)/PD modeling explored the relationship between siltuximab PK and CRP suppression following i.v. siltuximab infusion in a three-part phase I/II study in 68 metastatic renal cell carcinoma patients. Modeling results were then used to simulate and determine which siltuximab dosage regimens would maintain CRP suppression below the lower limit of quantification (4 mg/L). Siltuximab was given at 1, 3, 6, or 12 mg/kg at weeks 1 and 4 and then every 2 weeks for 2 cycles in part 1; at 3 or 6 mg/kg every 3 weeks for 4 cycles in part 2; and at 6 mg/kg every 2 weeks for 6 cycles in part 3. A two-compartment PK model adequately described the serum siltuximab concentration-time data. An inhibitory indirect response PD model examined the relationship between siltuximab concentrations and CRP suppression. PD parameter estimates seemed reliable and physiologically relevant. Simulations showed that 6 mg/kg siltuximab every 2 weeks or 9 mg/kg every 3 weeks would reduce serum CRP to below 4 mg/L. Using a stepwise design, PK/PD modeling was used to select the dose levels in this study. Furthermore, PK/PD modeling results were used to help select doses to be used in future siltuximab clinical development.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}163{"query": "Warming homes and other buildings is an obvious way that thermal energy can be used. Two common types of home heating systems are hot-water and warm-air heating systems. Both types are described below. You can watch an animation showing how a solar heating system works at this URL: A hot-water heating system uses thermal energy to heat water and then pumps the hot water throughout the building in a system of pipes and radiators. You can see a diagram of this type of heating system in Figure 18.12. Typically, the water is heated in a boiler that burns natural gas or heating oil. There is usually a radiator in each room that gets warm when the hot water flows through it. The radiator transfers thermal energy to the air around it by conduction and radiation. The warm air then circulates throughout the room in convection currents. The hot water cools as it flows through the system and transfers its thermal energy. When it finally returns to the boiler, it is heated again and the cycle repeats. A warm-air heating system uses thermal energy to heat air. It then forces the warm air through a system of ducts. You can see a diagram of this type of heating system in Figure 18.13. Typically, the air is heated in a furnace that burns natural gas or heating oil. When the air is warm, a fan blows it through the ducts and out through vents that are located in each room. Warm air blowing out of a vent moves across the room, pushing cold air out of the way. The cold air enters an intake vent on the opposite side of the room and returns to the furnace with the help of another fan. In the furnace, the cold air is heated, and the cycle repeats. Its easy to see how thermal energy can be used to keep things warm. But did you know that thermal energy can also be used to keep things cool? Cooling systems such as air conditioners and refrigerators transfer thermal energy in order to keep homes and cars cool or to keep food cold. In a refrigerator, for example, thermal energy is transferred from the cool air inside the refrigerator to the warmer air in the kitchen. You read in this chapters \"Transfer of Thermal Energy\" lesson that thermal energy always moves from a warmer area to a cooler area, so how can it move from the cooler refrigerator to the warmer room? The answer is work. The refrigerator does work to transfer thermal energy in this way. Doing this work takes energy, which is usually provided by electricity. Figure 18.14 explains how a refrigerator does its work. For an animated demonstration of how a refrigerator works, go to this URL: The key to how a refrigerator or other cooling system works is the refrigerant. A refrigerant is a substance, such as FreonTM, that has a low boiling point and changes between liquid and gaseous states as it passes through the cooling system. As a liquid, the refrigerant absorbs thermal energy from the cool air inside the refrigerator and changes to a gas. As a gas, it releases thermal energy to the warm air outside the refrigerator and changes back to a liquid. A combustion engine is a complex machine that burns fuel to produce thermal energy and then uses the energy to do work. Two basic types of combustion engines are external and internal combustion engines. An external combustion engine burns fuel externally, or outside the engine. The burning fuel releases thermal energy that is used to turn water to steam. The pressure of the steam is then used to move a piston back and forth in a cylinder. The kinetic energy of the moving piston can be used to turn a turbine or other device. Figure 18.15 explains in greater detail how this type of engine works. You can see an animated version of an external combustion engine at this URL: [Link] . An internal combustion engine (see Figure 18.16) burns fuel internally, or inside the engine. This type of engine is found in most cars and other motor vehicles. It works in these steps, which keep repeating: 1. A mixture of fuel and air is pulled into a cylinder through a", "pos": "The Sun is Earths main source of energy. The Sun gives us both light and heat. The Sun changes hydrogen into helium through nuclear fusion. This releases huge amounts of energy. The energy travels to the Earth mostly as visible light. The energy is carried through the empty space by radiation. We can use sunlight as an energy resource, called solar energy (Figure 5.7). Solar energy has been used on a small scale for hundreds of years. Today we are using solar energy for more of our power demands. Solar power plants are being built in many locations around the world. In the United States, the southwestern deserts are well suited for solar plants. Sunlight is turned into electricity at a solar power plant. These power plants use a large group of mirrors to focus sunlight on one place. This place is called a receiver (Figure 5.8). At the receiver, a liquid such as oil or water is heated to a high temperature. The liquid transfers its heat by conduction. In conduction, energy moves between two objects that are in contact. The higher temperature object transfers heat to the lower temperature object. For example, when you heat a pot of water on a stove top, energy moves from the pot to its metal handle by conduction. At a solar power plant, the energy conducted by the heated liquid is used to make electricity. Solar energy is used to heat homes and water, and to make electricity. Scientists and engineers have many ways to get energy from the Sun (Figure 5.9). One is by using solar cells. Solar cells are devices that turn sunlight directly into electricity. Lots of solar cells make up an individual solar panel. You may have seen solar panels on roof tops. The Suns heat can also be trapped in your home by using south facing windows and good insulation. Solar energy has many benefits. It does not produce any pollution. There is plenty of it available, much more than we could possibly use. But solar energy has problems. The Sun doesnt shine at night. A special battery is needed to store extra energy during the day for use at night. The technology for most uses of solar energy is still expensive. Until solar technology becomes more affordable, most people will prefer to get their energy from other sources. Moving water has energy (Figure 5.10). That energy is used to make electricity. Hydroelectric power harnesses the energy of water moving down a stream. Hydropower is the most widely used form of renewable energy in the world. This abundant energy source provides almost one fifth of the worlds electricity. The energy of waves and tides can also be used to produce water power. At this time, wave and tidal power are rare. To harness water power, a stream must be dammed. Narrow valleys are the best for dams. While sitting in the reservoir behind the dam, the water has potential energy. Water is allowed to flow downhill into a large turbine. While flowing downhill, the water has kinetic energy. Kinetic energy makes the turbine spin. The turbine is connected to a generator, which makes electricity. Many of the suitable streams in the United States have been developed for hydroelectric power. Many streams worldwide also have hydroelectric plants. Hydropower is a major source of Californias electricity. It accounts for about 14.5 percent of the total. Most of Californias nearly 400 hydroelectric power plants are located in the Sierra Nevada mountains. Water power does not burn a fuel. So it causes less pollution than many other kinds of energy. Water power is also a renewable resource. Water keeps flowing downhill. Although we use some of the energy from this movement, we are not using up the water. Water power does have problems. A large dam stops a streams flow, which floods the land upstream. A beautiful location may be lost. People may be displaced. The dams and turbines also change the downstream environment. Fish and other living things may not be able to survive. Dams slow the release of silt. Downstream deltas retreat and beaches may be starved of sand. Seaside cities may become exposed to storms and", "neg": "Energy from the Sun comes from the lightest element, hydrogen, fusing together to create the second lightest element, helium. Nuclear fusion on the Sun releases tremendous amounts of solar energy. The energy travels to the Earth, mostly as visible light. The light carries the energy through the empty space between the Sun and the Earth as radiation. Solar energy has been used for power on a small scale for hundreds of years, and plants have used it for billions of years. Unlike energy from fossil fuels, which almost always come from a central power plant or refinery, solar power can be harnessed locally (Figure 1.1). A set of solar panels on a homes rooftop can be used to heat water for a swimming pool or can provide electricity to the house. Societys use of solar power on a larger scale is just starting to increase. Scientists and engineers have very active, ongoing research into new ways to harness energy from the Sun more efficiently. Because of the tremendous amount of incoming sunlight, solar power is being developed in the United States in southeastern California, Nevada, and Arizona. Solar panels supply power to the Interna- tional Space Station. Solar power plants turn sunlight into electricity using a large group of mirrors to focus sunlight on one place, called a receiver (Figure 1.2). A liquid, such as oil or water, flows through this receiver and is heated to a high temperature by the focused sunlight. The heated liquid transfers its heat to a nearby object that is at a lower temperature through a process called conduction. The energy conducted by the heated liquid is used to make electricity. This solar power plant uses mirrors to focus sunlight on the tower in the center. The sunlight heats a liquid inside the tower to a very high temperature, producing energy to make electricity. Solar energy has many benefits. It is extremely abundant, widespread, and will never run out. But there are problems with the widespread use of solar power. Sunlight must be present. Solar power is not useful in locations that are often cloudy or dark. However, storage technology is being developed. The technology needed for solar power is still expensive. An increase in interested customers will provide incentive for companies to research and develop new technologies and to figure out how to mass-produce existing technologies (Figure 1.3). Solar panels require a lot of space. Fortunately, solar panels can be placed on any rooftop to supply at least some of the power required for a home or business. This experimental car is one example of the many uses that engineers have found for solar energy. Click image to the left or use the URL below. URL: Click image to the left or use the URL below. URL:", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}164{"query": "Nivolumab was developed as a monoclonal antibody against programmed death receptor-1, an immune checkpoint inhibitor which negatively regulates T-cell proliferation and activation. Intravenous administration of nivolumab was approved for the treatment of unresectable malignant melanoma in 2014 in Japan. When advanced melanoma patients were treated with nivolumab, median overall survival became longer. Overall survival rate was significantly better in nivolumab-treated melanoma patients than dacarbazine-treated melanoma patients. Nivolumab had an acceptable long-term tolerability profile, with 22% of patients experiencing grade 3 or 4 adverse events related to the drug. Therefore, nivolumab can become an alternative therapy for advanced malignant melanoma.", "pos": "On the basis of remarkable antitumor activity, programmed death receptor-1 (PD-1) inhibitors pembrolizumab and nivolumab were approved for the treatment of advanced melanoma in the second-line setting following progression on either CTLA-4 inhibitor ipilimumab or BRAF/MEK inhibitors (for BRAF mutated melanoma). Given hypothesized risk of triggering exacerbations of autoimmune diseases and/or chronic viral infections, clinical trials (including regulatory studies) evaluating checkpoint blocking antibodies PD-1 and CTLA-4 have excluded patients with autoimmune diseases, chronic hepatitis B/C virus (HBV/HCV), and/or human immunodeficiency virus (HIV) infections. Herein, we describe two patients with advanced melanoma and concomitant HCV/HIV infections treated with PD-1 inhibitor pembrolizumab. Patient 2 with HIV/HCV coinfection progressed after 2 doses of pembrolizumab. Patient 1 who had HCV alone was treated with pembrolizumab with initial partial response. HCV viral load remained stable after 9 cycles of pembrolizumab following which 12-week course of HCV-directed therapy was commenced, resulting in prompt reduction of HCV viral load below detectable levels. Response is ongoing and HCV viral load remains undetectable. In both patients, no significant toxicities were observed when pembrolizumab was initiated. We argue for the further investigation of checkpoint inhibition in cancer patients with underlying chronic viral infections in the context of carefully designed clinical trials.", "neg": "The mammalian target of rapamycin (mTOR) has been suggested as a target for radiosensitization. Given that radiotherapy is a primary treatment modality for glioblastoma (GBM) and that mTOR is often dysregulated in GBM, the goal of this study was to determine the effects of AZD2014, a dual mTORC1/2 inhibitor, on the radiosensitivity of GBM stem-like cells (GSCs). mTORC1 and mTORC2 activities were defined by immunoblot analysis. The effects of this mTOR inhibitor on the in vitro radiosensitivity of GSCs were determined using a clonogenic assay. DNA double strand breaks were evaluated according to H2AX foci. Orthotopic xenografts initiated from GSCs were used to define the in vivo response to AZD2014 and radiation. Exposure of GSCs to AZD2014 resulted in the inhibition of mTORC1 and 2 activities. Based on clonogenic survival analysis, addition of AZD2014 to culture media 1 hour before irradiation enhanced the radiosensitivity of CD133+ and CD15+ GSC cell lines. Whereas AZD2014 treatment had no effect on the initial level of H2AX foci, the dispersal of radiation-induced H2AX foci was significantly delayed. Finally, the combination of AZD2014 and radiation delivered to mice bearing GSC-initiated orthotopic xenografts significantly prolonged survival as compared with the individual treatments. These data indicate that AZD2014 enhances the radiosensitivity of GSCs both in vitro and under orthotopic in vivo conditions and suggest that this effect involves an inhibition of DNA repair. Moreover, these results suggest that this dual mTORC1/2 inhibitor may be a radiosensitizer applicable to GBM therapy.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}165{"query": "Transactivation response DNA-binding protein 43 (TDP-43) proteinopathies are classified based upon the extent of modified TDP-43 and include a growing number of neurodegenerative diseases such as amyotrophic lateral sclerosis, frontotemporal lobar degeneration with ubiquitin-immunoreactive, tau-negative inclusions and frontotemporal lobar degeneration with motor neuron disease. The purpose of the study was to examine whether proteolytic modifications of TDP-43 are a relevant finding in Parkinson's disease (PD) and dementia with Lewy bodies (DLB). A novel site-directed caspase cleavage antibody, termed TDP caspase cleavage product antibody (TDPccp), was utilized based upon a known caspase 3 cleavage consensus site within TDP-43 at position 219. Application of this antibody to postmortem brain sections from PD and DLB patients revealed the presence of caspase-cleaved TDP-43 in Lewy bodies and Hirano bodies in all cases examined. Colocalization of TDPccp with an antibody to alpha-synuclein (alpha-Syn), which served as a general marker for Lewy bodies, was evident within the substantia nigra in both alpha-synucleinopathies. Interestingly, the TDPccp antibody detected a greater number of Lewy bodies in PD and DLB compared to the alpha-Syn antibody. In addition, a semiquantitative analysis in both diseases confirmed this finding by indicating that the percentage of caspase-cleaved TDP-43 single-labeled Lewy bodies was approximately twice that of alpha-Syn labeling (in DLB 13.4 vs. 5.5%, while in PD 34.6 vs. 17.6%). Collectively, these data have identified caspase-cleaved TDP-43 as a primary component of Lewy and Hirano bodies in PD and DLB, and suggest that the TDPccp antibody is an effective marker for the detection of Lewy bodies in these neurodegenerative diseases.", "pos": "Using post-embedding immunogold electron microscopy, TAR DNA-binding protein of 43 kDa (TDP-43) was localized to neuronal cytoplasmic (NCI) and intranuclear (NII) inclusions, as well as unmyelinated neurites, in frontotemporal lobar degeneration with ubiquitinated inclusions (FTLD-U), amyotrophic lateral sclerosis (ALS), Alzheimer's (AD), Pick's disease (PiD) and Lewy body disease (LBD). The TDP-43 immunoreactive structures were morphologically heterogeneous. The most common was characterized by bundles of 10-20 nm diameter straight filaments with electron dense granular material within NCI, NII and neurites. This type of pathology was found in FTLD-U, ALS and some cases of AD. Less often, inclusions in neuritic processes of FTLD-U and some cases of AD contained 10-17 nm diameter straight filaments without granular material. A final type of TDP-43 immunoreactivity was labeling of filaments and granular material associated with tau filaments in neurofibrillary tangles of AD and Pick bodies of PiD or alpha-synuclein filaments in Lewy bodies of LBD. The results suggest that TDP-43 is the primary component of the granulofilamentous inclusions in FTLD-U and ALS. Similar inclusions sometimes accompany filamentous aggregates composed of other abnormal proteins in AD, PiD and LBD.", "neg": "Abnormal accumulation of Abeta and tau in senile plaques (SP) and neurofibrillary tangles (NFTs) is a key event in Alzheimer's disease (AD). Here, we show that T668-phosphorylated cytoplasmic domain of APP (pT668-ACD) accumulates Abeta and tau in AD and its transgenic models. Anti-pT668 immunostaining of AD brain sections with hydrated autoclave enhancement identified SP neurites and NFTs in which pT668-ACD colocalizes with tau. We produced and examined transgenic (Tg) mice that overexpress human APP695, harboring the double Swedish/London mutation, and develop age-dependently Abeta plaques in the brain. All Abeta plaques contain co-accumulations of pT668-ACD, but co-accumulation of tau appears in only a fraction of Abeta plaques in older animals. We also examined the established tau Tg mice that overexpress the smallest human brain tau isoform and develop neuronal accumulations of tau in older animals. Examination of the old tau Tg mice showed that neuronal cells affected by tau accumulation induce co-accumulation of pT668-ACD. We speculate that in AD brains, extracellular Abeta deposition is accompanied by intracellular accumulation of pT668-ACD, followed by tau accumulation in the SP with dystrophic neurites and that neuronal cells affected by tau accumulation induce co-accumulation of pT668-ACD in NFTs. Thus, pT668-ACD is likely to mediate pathological interaction between Abeta and tau.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}166{"query": "Maria is a free-spirited young Austrian woman studying to become a nun at Nonnberg Abbey in Salzburg in 1938. Her love of music and the mountains, her youthful enthusiasm and imagination, and her lack of discipline cause some concern among the nuns. The Mother Abbess, believing Maria would be happier outside the abbey, sends her to the villa of retired naval officer Captain Georg von Trapp to be governess to his seven childrenLiesl, Friedrich, Louisa, Kurt, Brigitta, Marta, and Gretl. The Captain has been raising his children alone using strict military discipline following the death of his first wife. Although the children misbehave at first, Maria responds with kindness and patience, and soon the children come to trust and respect her. While the Captain is away in Vienna, Maria makes play clothes for the children and takes them around Salzburg and the surrounding mountains, and she teaches them how to sing. When the Captain returns to the villa with Baroness Elsa Schraeder, a wealthy socialite, and their mutual friend, Max Detweiler, they are greeted by Maria and the children returning from a boat ride on the lake that concludes when their boat overturns. Displeased by his children's clothes and activities, and Maria's impassioned appeal that he get closer to his children, the Captain orders her to return to the abbey. Just then he hears singing coming from inside the house and is astonished to see his children singing for the Baroness. Filled with emotion, the Captain joins his children, singing for the first time in years. Afterwards, he apologizes to Maria and asks her to stay. Impressed by the children's singing, Max proposes he enter them in the upcoming Salzburg Festival but the suggestion is immediately rejected by the Captain who will not allow his children to sing in public. He does agree, however, to organize a grand party at the villa. The night of the party, while guests in formal attire waltz in the ballroom, Maria and the children look on from the garden terrace. When the Captain notices Maria teaching Kurt the traditional Landler folk dance, he cuts in and partners with Maria in a graceful performance, culminating in a close embrace. Confused about her feelings, Maria blushes and breaks away. Later, the Baroness, who noticed the Captain's attraction to Maria, hides her jealousy while convincing Maria that she must return to the abbey. Back at the abbey, when Mother Abbess learns that Maria has stayed in seclusion to avoid her feelings for the Captain, she encourages her to return to the villa to look for her life. After Maria returns to the villa, she learns about the Captain's engagement to the Baroness and agrees to stay until they find a replacement governess. The Captain's feelings for Maria, however, have not changed, and after breaking off his engagement the Captain and Maria are married. While they are on their honeymoon, Max enters the children in the Salzburg Festival against their father's wishes. When they learn that Austria has been annexed into the Third Reich in the Anschluss, the couple return to their home, where a telegram awaits informing the Captain that he must report to the German Naval Headquarters in Bremerhaven to accept a commission in the German Navy. Strongly opposed to the Nazis and the Anschluss, the Captain tells his family they must leave Austria immediately. That night, as the von Trapp family attempt to leave, they are stopped by German soldiers waiting outside the villa. When questioned by Gauleiter Hans Zeller, the Captain maintains they are headed to the Salzburg Festival to perform. Zeller insists on escorting them to the festival, after which his men will accompany the Captain to Bremerhaven. Later that night at the festival, during their final number, the von Trapp family slip away and seek shelter at the nearby abbey, where Mother Abbess hides them in the cemetery crypt. Nazi soldiers soon arrive and search the abbey, but the family is able to escape using the caretaker's car. When the soldiers attempt to pursue, they discover their cars will not start as two nuns have removed parts of their engines. The next morning, after driving to the border, the von Trapp family make their", "pos": "Zandalee Martin (Erika Anderson) is a young boutique store owner living in New Orleans who is sexually frustrated and feeling unfulfilled with her marriage to Thierry Martin (Judge Reinhold), and eventually gets tangled in a passionate, sensual and torrid adulterous affair with her husband's mysterious and free spirited old friend Johnny Collins (Nicholas Cage).Zandalee and Thierry's marriage has hit a snag and seems to be eroding due to his lack of passion. Zan needs to explore, while Thierry wants to withdraw, and has become more and more distant and impotent in their relationship. He used to be a poet, but now has taken over the familys communications business after the death of his father. As time goes on, Thierry has to sell the business and become basically a (vice president) figurehead. He is emotionally adrift as his dreams give way to disillusionment.Johnny, an artist painter by trade, has been working for Thierry's business to help support his paintings. His only religion is self-gratification. Johnny also sells and mules cocaine for a local drug dealer as another source of income for himself.Having not seen each other in a while, the two run in to each other at a bachelor's party. After the party, Thierry brings Johnny home to meet Zandalee and his grandmother Tatta (Viveca Lindfors). While talking about old times, Johnny offers to paint a portrait of Thierry at their home.Later, after finishing the painting, Johnny shows it to Thierry, Zandalee and Tatta. While they go off to other rooms and sensing Zandalee's frustration and vulnerability, Collins makes a pass at her. Johnny continues to pursue her and when they run into each other during a rain storm, he takes advantage and moves in by seducing her, first in his loft in an angry passionate scene, (interestingly, Zan's wedding ring is on the table next to the bed) which is followed by him erotically finger painting her. Their sexual liaisons continue to occur in various places including her laundry room a top a washing machine while Thierry and guests are having dinner. Thierry soon suspects the two are having an affair.As the affair intensifies, Johnny meets Zandalee in a local church and asks her to leave her husband. However, Zandalee feels that she must never abandon her true love Thierry, and quickly ends her affair with Johnny after he forces himself on her in the confessional. She and Thierry re-commit themselves to each other, but Johnny, now obsessed with her, will not be brushed off that easily. He tracks them to their vacation spot in the Bayou. All of this puts the three on a destructive collision course with a tragic sequence of events.When Thierry figures out that Johnny has indeed been having an affair with Zandalee, he becomes drunk and confrontational (he pulls a gun out) leading to him becoming reckless when he takes Zan and Johnny for a speedboat ride on the Bayou, which ends when he falls off the boat and drowns, refusing to be saved by either Zan or Johnny who dive into the water to save him.Both Zandalee and Johnny become distraught by Thierry's death and begin to isolate themselves with Zan jogging for long periods and Johnny trying to work on his paintings, but becoming more self-destructive. In one scene, Johnny, in a rage rips up some of his paintings and pours black paint all over himself. He also consumes some of the cocaine he is supposed to sell, which gets him in trouble with his supplier.When Johnny meets with Zandalee with the hopes to re-start their romance and have a possible future together now that Thierry is out of the picture, she remains emotionally distant and instead goes for a walk along the Old Quarter with Johnny following her. But in the final scene, when Johnny's drug supplier attempts to kill him in a drive-by shooting outside the church that Zandalee frequents, she sees what is about to happen and shields Johnny, getting fatally shot in the process. The drug dealer flees from the scene of the crime (saying \"you've got to make accounts payable man\"), leaving behind Johnny, now alone, as he", "neg": "A lonely old woman who longs for a child is given a seed by a good witch. When planted, the seed grows into a flower, and inside the blossom is a tiny girl the size of the old woman's thumb. The old woman names the girl Thumbelina and raises her as her own. Although Thumbelina loves her mother, she craves companionship from someone her own size. One night, Cornelius, the fairy prince, stumbles upon Thumbelina after hearing her beautiful singing. The two take a ride on Cornelius' bumblebee, and fall in love; during this ride Mrs. Toad and her son Grundel are enchanted by Thumbelina's singing. Cornelius promises to return the next day, but after he's gone, Mrs. Toad kidnaps Thumbelina from her bed and takes her away. Thumbelina awakens on Mrs. Toad's show boat. Mrs. Toad wants Thumbelina to join their troupe and marry Grundel, who is in love with her. They leave Thumbelina alone on a lily pad in order to fetch a priest, but a friendly swallow, Jacquimo (the narrator of the film), overhears Thumbelina's cries for help and frees her. Jacquimo's friends, the jitterbugs, promise to help Thumbelina get home safely while Jacquimo sets off to find Cornelius. Meanwhile, Cornelius learns of Thumbelina's kidnapping and ventures out to find her. While trying to get home, Thumbelina is ambushed by Berkeley Beetle, who scares the jitterbugs away. He is enamoured with her singing, and promises to show her the way home if she sings at his Beetle Ball first. Thumbelina agrees, but when she's received poorly at the Beetle Ball, Beetle kicks her out without helping her. Winter is approaching. Jacquimo accidentally impales his wing on a thorn and is knocked out by the cold, while Cornelius falls into a lake and is frozen in ice. Grundel, who is searching for Thumbelina, finds Beetle and discovers she is in love with Prince Cornelius and upon some convincing from Beetle, decides to find and kidnap Cornelius to lure Thumbelina to him. Grundel forces Beetle to help him as Grundel steals his wings and won't return them until Beetle has found and captured Cornelius. Thumbelina is taken in by Miss Fieldmouse, who tells her that Cornelius has died. The two visit Miss Fieldmouse's neighbor, Mr. Mole who tells them about a dead bird he found in his tunnel earlier that day. It turns out to be Jacquimo, who Thumbelina discovers to be only unconscious. Mr. Mole wishes to marry Thumbelina; heartbroken over Cornelius's death, Thumbelina accepts. Jacquimo awakens under Thumbelina's care and leaves to find Cornelius, refusing to believe that he is dead. Meanwhile, Beetle brings Cornelius's frozen body to Grundel and informs him that Thumbelina is going to marry the Mole. After the two leave to stop the wedding, the young jitterbugs thaw Cornelius's body out. At the wedding, Thumbelina realizes at the last moment that she can't marry someone she does not love and refuses to take the vows. Grundel and Beetle crash the wedding, but Thumbelina flees from them and Mr. Mole. Cornelius intercepts the crowd and confronts Grundel, the ensuing fight resulting in them both falling into an abyss. Once outside and free, Thumbelina is reunited with Jacquimo, who takes her to Cornelius' kingdom, the Vale of the Fairies. Cornelius appears, having survived the fall, the pair are reunited, and Thumbelina accepts his proposal of marriage. The two kiss, and Thumbelina is granted her own wings. With Thumbelina's mother and the fairy court in attendance, Thumbelina and Cornelius are married and depart on their honeymoon on Cornelius's bumblebee. Images shown during the credits reveal that Beetle resumed his singing career and had gotten his wings back, Ms. Fieldmouse married Mr. Mole, and Grundel also survived the fall with minor injuries and married a female toad (implying that he lost interest in Thumbelina).", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}167{"query": "Some people bring out the best in you in a way that you might never have fully realized on your own. My mom was one of those people. My father died when I was nine months old, making my mom a single mother at the age of eighteen. While I was growing up, we lived a very hard life. We had little money, but my mom gave me a lot of love. Each night, she sat me on her lap and spoke the words that would change my life, \"Kemmons, you are certain to be a great man and you can do anything in life if you work hard enough to get it.\" At fourteen, I was hit by a car and the doctors said I would never walk again. Every day,my mother spoke to me in her gentle,loving voice, telling me that no matter what those doctors said, I would walk again if I want to badly enough. She drove that message so deep into my heart that I finally believed her.A year I returned to school--walking on my own ! When the Great Depression hit, my mom lost her job. Then I left school to support the both of us. At that moment, I was determined never to be poor again. Over the years, I experienced various levels of business success. But the real turning point occurred on a vacation I took with my wife and five kids in1951. I was dissatisfied with the second-class hotels available for families and was angry that they charged an extra $2 for each child. That was too expensive for the average American family. I told my wife that I was going to open a motel for families that would never charge extra for children. There were plenty of doubters at that time. Not surprisingly, Mom was one of my strongest supporters. She worked behind the desk and even designed the room style. As in any business,we experienced a lot of challenges. But with my mother's words deeply rooted in my soul, I never doubted we would succeed.Fifteen years later,we had the largest hotel system in the world--Holiday Inn. In 1979 my company had 1759 inns in more than fifty countries with an income of $1billion a year. You may not have started out life in the best situations. But if you can find a task in life worth working for and believe in yourself, nothing can stop you.", "pos": "I will always remember my mother's last days in this world. On February 14th, 2008, my class went on a field trip to the beach. I had so much fun. When we returned to school, my teacher told me to go to the headmaster's office. When I got into the office, I saw a police officer. Suddenly, I realized something was wrong. The police officer told me what had happened and we went to pick my sister up. After that, we went to the hospital and waited. Time went slowly. Finally, we got to see our mother. It was terrible. On the next day, the headmaster came and told my two teachers what had happened. I was taking a test that day. I knew it had something to do with my mother. I kept thinking that she either died or had gotten better. How I wished that she had gotten better. When my teacher took me outside, my sister ran up to me. She started crying, \"She's gone, Terresa, mommy's gone. She's dead.\" I couldn't believe it. We jumped into the car and drove straight to the hospital. Most of my family were there. The silence was terrible. I knew I had to say goodbye. Today when I look back, I still miss my mother very much, but I know that I will live. My mother was a strong mother, who had the biggest heart. She was an angel walking on the earth. I will always remember her as a living. When someone is asked who their hero is, they usually say someone famous, like Michael Jordan or Britney Spears. When someone asks me who my hero is, I tell them, my mother. My mother lives everyday. That is what makes her a true hero.", "neg": "My grandson, Daniel, and I have always been very close. When Daniel's father remarried after a divorce, Daniel, who was eleven, and his little sister, Kristie, came to live with us. My husband and I were more than happy to have kids in the house again. Things were going along just fine until the diabetes I've lived with most of my adult life started affecting my eyes, and then more seriously, my kidneys . Then everything seemed to fall apart. Three times a week, I had to go to the hospital to be hooked up to a dialysis machine . I was living, but I couldn't really call it a life -- it was an existence. I had no energy. I dragged myself through daily chores and slept as much as I could. My sense of humor seemed to disappear. Daniel, seventeen by then, was really affected by the change in me. He tried as hard as he could to make me laugh, to bring back the grandma who loved to clown around with him. Even in my sorry state, Daniel could still bring a smile to my face. But things were not improving. After a year on dialysis, my condition was deteriorating and the doctors felt that if I didn't receive a kidney transplant within six months, I would surely die. No one told Daniel this, but he knew -- he said all he had to do was look after me. To top it off, as my condition worsened, there was a chance that I would become too weak to have the transplant surgery at all, and then there would be nothing they could do for me. So we started the tense and desperate wait for a kidney. I was adamant that I didn't want a kidney from anyone I knew. I would wait until an appropriate kidney became available, or I would literally die waiting. But Daniel had other plans. The time that he took me to my dialysis appointments, he did a little secret research on his own. Then he announced his intention to me. \"Grandma, I'm giving you one of my kidneys. I'm young and I'm healthy ...\" He paused. He could see I wasn't at all happy with his offer. He continued, almost in whisper, \"And most of all, I couldn't stand it if you weren't around.\" His face wore an expression of appeal mixed with determination. He can be as stubborn as a mule once he decides on something -- but I've been told many times that I can out-stubborn any mule! We argued. I couldn't let him do it. We both knew that if he gave up his kidney, he would also give up his life's dream; to play football. It was all he ever talked about. And he was good, too. Daniel was co-captain and star defensive tackle of his high school team; he expected to apply for a football scholarship and was looking forward to playing college football. He just loved the sport. \"How can I let you throw away the thing that means the most to you?\" I pleaded with him. \"Grandma,\" he said softly, \"compared to your life, football means nothing to me.\" After that, I couldn't argue anymore. So we agreed to see if he was a good donor match, and then we'd discuss it further. When the tests came back, they showed Daniel was a perfect match. That was it. I knew I wasn't going to win that argument, so we scheduled the transplant. Both surgeries went smoothly. As soon as I came out of the anesthesia , I could tell things were different. I felt great! The nurses in the intensive care unit had to keep telling me to lie back and be quiet -- I wasn't supposed to be that lively! I was afraid to go to sleep, for fear I would break the spell and wake up the way I had been before. But the good feeling didn't go away, and I spent the evening joking and laughing with anyone who would listen.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}168{"query": "The Patriots clinched their fourth straight AFC East title with a close road win. After a scoreless first quarter, the Jaguars responded to a Gostkowski field goal with a Maurice Jones-Drew touchdown run. The Patriots challenged the play, as Jones-Drew appeared to fall down at the line of scrimmage, but the ruling on the field was upheld. New England came back before the halftime to retake the lead at 10-7 on a Dillon one-yard touchdown run. The Patriots maintained their lead as the teams traded touchdowns in the second half, including another touchdown by Jones-Drew. A David Garrard fumble with 1:55 left in the fourth quarter, recovered by safety Rodney Harrison, sealed the Patriots' 11th win of the season.", "pos": "The Browns traveled to Indianapolis to take on an Andrew Luck-led Colts offense. The Colts were able to score in the first quarter as Andrew Luck ran for a 3-yard touchdown making the score 7-0 for the only score of the game. The Browns responded in the 2nd quarter coming within a point when Brandon Weeden found Greg Little on a 14-yard pass (with a failed PAT) making the score 7-6. Then, Luck ran for another touchdown this time from 5 yards out to make the score 14-6 at halftime. The Browns came within a point again in the 3rd quarter as Weeden found Josh Gordon on a 33-yard pass making the score 14-13 but the Colts wrapped things up with Adam Vinatieri's 38-yard field goal followed by a scoreless 4th quarter making the final score 17-13 as the Browns' road record at this point of the season was 0-4 while their record overall was 1-6.", "neg": "This game is well known for an infamous penalty that occurred during the overtime period. The Jets were lining up for a game winning 56-yard field goal in overtime to try and give them the win. Nick folk kicked the ball, but the kick went wide right and the Patriots appeared to be taking over with a chance to win. However, Chris Jones of New England was called for a controversial unsportsmanlike conduct penalty after pushing his teammate into the offensive line. This penalty would later be named \"leaping\". The penalty gave the Jets another chance and made the field goal attempt a 51-yard attempt. This time, Folk drilled the kick, and the Jets would go on to stun the Patriots. With the win, the Jets improved to 4-3.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}169{"query": "As of the census of 2000, there were 35,100 people, 12,759 households, and 9,071 families residing in the county. The population density was 59 people per square mile (23/km). There were 15,035 housing units at an average density of 25 per square mile (10/km). The racial makeup of the county was 85.8% Race (United States Census), 3.9% Race (United States Census) or Race (United States Census), 1.8% Race (United States Census), 1.0% Race (United States Census), 0.1% Race (United States Census), 5.0% from Race (United States Census), and 2.4% from two or more races. 8.9% of the population were Race (United States Census) or Race (United States Census) of any race. 14.9% were of German people, 12.6% English people, 11.7% Irish people, 8.8% Italian people and 7.3% United States ancestry according to Census 2000. 93.1% spoke English language and 5.1% Spanish language as their first language.", "pos": "As of the census of 2000, there were 325,957 people, 149,937 households, and 94,460 families residing in the county. The population density was 570 people per square mile (220/km2). There were 182,467 housing units at an average density of 319 per square mile (123/km2). The racial makeup of the county was 92.65% Race (United States Census), 4.18% Race (United States Census) or Race (United States Census), 0.22% Race (United States Census), 0.77% Race (United States Census), 0.03% Race (United States Census), 1.14% from Race (United States Census), and 1.02% from two or more races. 4.34% of the population were Race (United States Census) or Race (United States Census) of any race. 89.7% spoke only English language at home; 4.4% spoke Spanish language, 1.3% German language, and 1.0% French language at home.", "neg": "As of the census of 2000, there were 120,546 people, 41,668 households, and 32,292 families residing in the county. The population density was 262 people per square mile (101/km). There were 43,903 housing units at an average density of 95 per square mile (37/km). The racial makeup of the county was 68.51% Race (United States Census), 26.06% Race (United States Census) or Race (United States Census), 0.75% Race (United States Census), 1.82% Race (United States Census), 0.06% Race (United States Census), 0.72% from Race (United States Census), and 2.08% from two or more races. 2.26% of the population were Race (United States Census) or Race (United States Census) of any race. 11.6% were of german people, 10.8% irish people, 10.2% english people, 9.3% American and 5.3% italian people ancestry.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}170{"query": "In 1957, when second-graders Bryce Loski and Julianna \"Juli\" Baker first meet, Juli knows it's love, but Bryce isn't so sure. Girl-phobic and easily embarrassed, young Bryce does everything he can to keep away as much as possible from Juli for the next six years, which isn't easy since they go to the same school and live across the street from each other. When they start the sixth grade, Bryce hopes that he can get rid of Juli so he asks the girl Juli hates the most, Shelly Stalls, out on a date. This plan of Bryce's works for a while up until his best friend, Garrett, takes an interest in Shelly and tells her the truth about Bryce asking her out. Juli finds out Bryce and Shelly break up; she goes back to her regular Bryce-obsessed self.From Juli's point of view, when she and Bryce first met, he returned her feelings but was just shy and embarrassed. When he \"held her hand\" she thought she would get her first kiss from him in the second grade. Juli knew that she was flipped from then on. After finding out that Bryce and Shelly broke up, she thought she could have her old Bryce back. She spent the whole year smelling his watermelon-scented hair and wondering if she'd ever get her kiss.In 1963, now in seventh grade, Bryce's grandfather Chet Duncan moves in with the family. Chet finds Juli different, special, and a rare kind of girl who's hard to come across. He continues to tell Bryce this with hope. There's a large, old sycamore tree that Juli loves which no one understands. One day, it's cut down by the owner in spite of Juli's protest and dismay. Her voice narrates her love for the tree that let her see the world in a much more enlightened way.Chet and Juli form a strong friendship over time while he helps her work on her messy lawn. Bryce begins to develop feelings for Juli just as Juli begins to question her feelings about Bryce. Her feelings completely disappear when she overhears him and Garrett talking about her mentally challenged uncle, and sees him throwing away the eggs she gave him. Juli tells Bryce she never wants to speak to him again when she and her family get invited to the Loski's house for a sit down dinner which ends up with Bryce's dad being considerably rude to her family. At the dinner she confronts him about what Bryce said about her uncle and tells him she doesn't want to speak to him again, not ever. During dinner, they sit opposite each other, she never talks or makes eye contact with him. After dinner she apologizes for the way she acted. Bryce is upset that she apologizes, because that means that she doesn't care enough to hold a grudge.She continues to have mixed feelings when the basket boy auction is just around the corner. She hears that Shelly is planning to bid on Bryce against another one of the school's \"finest\" girls. Bryce thinks that Juli is planning on bidding for him because he hears she walked in with a wad of cash (which she wasn't planning on having with her). Bryce begins to worry about what would happen if she does bid for him just when she bids all her cash on basket boy number eight, the boy before Bryce.Later, during the basket boy bidding lunch, Bryce and Shelly sit at a table across from Juli and basket boy number 8, Eddie Trulock. She's facing Bryce and he can't help but stare at Juli the whole time. He sees she's having a good time with her date and gets jealous. He grabs her to talk to her and attempts to kiss her in front of everyone. He chases her after she dodges his kiss. Juli gets on her bike and cycles as fast as she can home. Garrett chases after him, and the two break off their friendship after a confrontation.Juli bikes home crying. Bryce continuously tries to talk to her, ringing the doorbell, calling her house, coming to her bedroom", "pos": "The film explores adolescent issues through the minds of three friends and their reactions after a boy named Rudy Carges (Conor Donovan) is killed in a tree house set on fire by local bullies Jeff and Kenny, who carelessly didn't find out he was inside until too late. The boy's twin brother Jacob, a boy with a huge birthmark (also played by Donovan), decides to seek revenge against the bullies. Leonard (Jesse Camacho) who's overweight, survives the tree house fire but loses his sense of taste and smell. Thanks to the fire, this prompts Leonard to go on a diet, which isn't welcomed by his obese family. The boys' female friend Malee (Zoe Weizenbaum) tries to befriend an adult named Gus (Jeremy Renner), a grief-stricken patient of her therapist mother, Carla (Annabella Sciorra). Jacob's family falls apart after the death of his brother. But shortly after, his parents adopt a boy named Keith Gardner. Meanwhile, Malee begins to have a crush on Gus and changes the song for her recital to one Gus liked, just for him. As time goes by, she sees Gus as her \"soul mate\". She sneaks into his house one night to find him grieving. Afraid to confront him, Malee steals his gun and leaves. She gives it to Jacob the following day. Jacob frequently visits Jeff and Kenny, who are serving time in a juvenile hall. Jacob initially threatens them, until eventually Jeff commits suicide. Jacob befriends Kenny, soon learning he has an early release and is illegally moving to New Mexico. Meanwhile, Leonard's father decides to take his sisters to Florida instead of Leonard (who would usually go). Leonard decides to force his mother to lose weight by trapping her in the cellar. They both end up in the hospital after a gas leak in their home. Next, Jacob and Kenny agree that Jacob can go with him to New Mexico. Malee visits Gus and removes her clothes in an attempt to seduce him. Instead, Gus calls Malee's mother to come and pick her up. The next day, Gus explains to therapist Carla about the last fire he ever fought (which involved killing an injured little girl, upon the girl's request), claiming that Malee wanted him to take her pain away, as he was aware of her growing crush on him. Meanwhile, Jacob's mother tells him that Keith Gardner wasn't adopted to replace Rudy, and that she wants Kenny dead, which reminds Jacob of his planned revenge. The night of escape for Jacob finally comes and he meets up with Kenny. Jacob insists on going through a construction site which he says is a secret route. Once there, Jacob points Gus's gun at Kenny, and tells him \"you killed him\" before shooting him dead. Jacob buries the body and leaves. He returns in the daytime, and sees Gus spreading cement above Kenny's grave. Malee begins visiting her estranged father and Leonard's family finally starts eating healthily. The movie ends with Jacob's mother smiling at him from inside the house.", "neg": "Rachel (Andrea Bowen), a high school girl, seems to have the life that most people envy: she has a steady boyfriend, some great friends, and a place on the school's soccer team. Preparing for college and separating from her boyfriend are the main worries of this teen, as she lives a carefree life like most girls her age. However, Rachel's world falls apart the day she discovers that Jason (Eric von Detton), a former sexual partner of hers that died an untimely death, was in fact HIV positive and an IV drug user. She immediately goes to an AIDS clinic to get a rapid test, which unfortunately comes back positive. Devastated by the fact that she may actually be infected with the virus, Rachel then confides in her substitute teacher, Sarah (Jennie Garth), who has secretly been living with the disease for years. But both young women are about to find out their secrets will not be kept secret for very long, as word begins to spread throughout their high school and rumors fly, making some of these students realize that they may not be as \"clean\" as they think they are.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}171{"query": "Brink (Sir Cedric Hardwicke) has recently taken Pud's (Bobs Watson) parents in an auto wreck. Brink later comes for Gramps (Lionel Barrymore). Believing Brink to be an ordinary stranger, the crotchety old Gramps orders Mr. Brink off the property. Pud comes out of the house and asks who the stranger was. Gramps is surprised and relieved that someone else could see the stranger; he was not merely a dream or apparition. Pud tells Gramps that when he does a good deed, he will be able to make a wish. Because his apples are constantly being stolen, Gramps wishes that anyone who climbs up his apple tree will have to stay there until he permits them to climb down. Pud inadvertently tests the wish when he has trouble coming down from the tree himself, becoming free only when Gramps says he can. Pud's busybody Aunt Demetria (Eily Malyon) has designs on Pud and the money left him by his parents. Gramps spends much time fending off her efforts to adopt the boy. Brink takes Granny Nellie (Beulah Bondi) in a peaceful death just after she finishes a bit of knitting. When Mr. Brink returns again for Gramps, the old man finally realizes who his visitor is. Determined not to leave Pud to Demetria, Gramps tricks Mr. Brink into climbing the apple tree. While stuck in the tree, he cannot take Gramps or anyone else. The only way anyone or anything can die is if they touch Mr. Brink or the apple tree. Demetria plots to have Gramps committed to a psychiatric hospital when he claims that Death is trapped in his apple tree. Gramps proves his story first by proving that his doctor, Dr. Evans (Henry Travers), can not even kill a fly they have captured. He offers further proof of his power by shooting Mr. Grimes (Nat Pendleton), the orderly who has come to take him to the asylum; Grimes lives when he should have died. Dr. Evans is now a believer, but he tries to convince Gramps to let Death down so people who are suffering can find release. Gramps refuses, so the doctor arranges for the local sheriff to commit Gramps while Pud is delivered to Demetria's custody. With the help of his housekeeper (Una Merkel), Gramps tricks both of them into believing they are scheduled to go with Mr. Brink when he comes down from the tree. They beg Gramps to convince Brink otherwise, and Demetria vows never to bother Gramps or Pud again. Gramps realizes that sooner or later he will have to let Brinks downDeath is an ultimately unavoidable part of life. He tries to say goodbye to Pud, who reacts angrily and tries to run away. Mr. Brink sees Pud in the yard and dares him to climb the tree. Pud gets over the fence Gramps has had built around the tree, but falls and is crippled for life. Distraught, Gramps lets Death down from the tree. He takes both Gramps and Pud, who find they can walk again. In the final scene, they walk together up a beautiful country lane and hear Granny Nellie calling to them from beyond a brilliant light.", "pos": "Harvey Shine (Dustin Hoffman) works as a jingle writer for television commercials in Manhattan, a job not in keeping with his one-time aspiration to be a jazz composer and pianist. We see him at work and he is very good at what he does. However, his boss does not seem impressed with his latest output. As Harvey departs for London to attend his daughter Susan's wedding, his boss actually suggests that he spend more time there than he had originally planned. Harvey declines, making the point that he needs to be back for an upcoming pitch to an old client. His boss insists that it is being done by other musicians, and that Harvey's latest work was his last chance to keep his job.On the plane, Harvey tries to chat up a fellow passenger, but she is having none of it. He is left sitting there with egg on his face and we come to regard him as even more of a loser.Meanwhile, we witness the mildly strained relationship between Kate Walker (Emma Thompson), a single Londoner, and her mother, whose husband left years earlier. Kate tries to reassure her mother that despite being single, she may yet find a man. Further, Kate tells her mom to quit worrying about the new Polish neighbor who has moved in next door and seems to be stacking a lot of firewood.Upon arrival at Heathrow Airport in London, Harvey encounters Kate at her job collecting statistics from passengers as they pass through the terminals. She attempts to question him about his reasons for visiting the UK. Tired and anxious to get to his hotel, Harvey brusquely dismisses her when she approaches him to ask questions.Harvey heads for the hotel to check in and discovers that he is the first one to arrive. Upon calling his daughter to double check where everyone else is when they were all supposed to be staying together, he learns that his ex-wife Jean actually rented a house to accommodate family and friends from the States and he is the only one at the hotel.After a brief nap, he showers and hurriedly dresses. On the way to the rehearsal dinner in the taxi cab, he realizes the anti-shoplifting device is still attached to the sleeve of his jacket. And to make matter worse, he has worn a white suit (thinking this was requested) while all the other men wore black. During the meal, it becomes increasingly clear Harvey is considered a mere guest and the role of father of the bride has been delegated to Jean's husband Brian. To add insult to injury, Brian stands to give the toast, and recollects the vacation they all spent in Rome, and his stepson-in-law-to-be embraces him and calls him Dad. Just before leaving back to his hotel, when Harvey tells Susan (with whom he has shared a strained relationship since his divorce) that he will be attending the ceremony but not the subsequent reception because he needs to return to the States for an important meeting, she informs him she has asked Brian to give her away.Meanwhile, Kate is set up on a blind date by a well meaning co-worker that does not go well. When she returns to the table after taking yet another call from her mother, she discovers her younger date has invited some of his younger friends to join them. Feeling unwanted and excluded from the conversation, she eventually excuses herself and goes home. As it turns out, Kate's increasingly neurotic mother seems convinced that her Polish neighbor is some kind of murderer because she sees him toting strange looking, lumpy packages into a shed in the back yard.The following morning Harvey attends Susan's wedding, but heavy traffic delays his arrival back to Heathrow, and he misses his plane. When he calls his boss Marvin in NYC to inform him he will be returning a day later than planned and that he will try to get there as soon as possible, he is told that he is fired.In his glum mood, Harvey makes his way to the airport bar and starts slugging down scotch, determined to drown his sorrows. Kate is sitting in the lounge reading", "neg": "In 1982, in New Jersey, Gracie (Mary Ashleigh Green) is in a school playground where one boy is bullying another. She steps in and beats up the bully to help the victim, a boy she likes. But instead of being grateful, he feels humiliated at being rescued \"by a girl,\" and gets angry at her. She promptly punches him in the nose and then sulks alone in the playground. Fast-forward to the present day, and Gracie Hart (Sandra Bullock) is an FBI Special Agent. In the middle of an operation against Russian mobsters, the target starts to choke on some food, and Gracie disobeys her superior's command in order to prevent the target from choking. As a result, a member of her squad gets shot, and she is reprimanded by being reassigned to a desk job. Soon afterwards, the bureau learns that there has been a bomb threat against the 75th annual Miss United States beauty pageant in San Antonio, Texas, which the bureau determines came from the notorious domestic terrorist known as \"The Citizen\". Gracie's partner, Special Agent Eric Matthews (Benjamin Bratt), is chosen to lead the mission to prevent the attack. Despite Eric's position as a lead agent in charge, it is apparent that Gracie is the more capable agent, as Eric is unsure of how to proceed and takes credit for Gracie's suggestions. One of Gracie's suggestions is to put an agent undercover at the pageant. Gracie's male colleagues then proceed to have a bit of fun running the digital images of female and male agents through a website meant for children to play dress up with their dolls. Despite the immature and chauvinistic actions of the agents, Eric recognizes that Gracie is the female FBI agent best qualified for the undercover job. Beauty pageant coach Victor Melling (Michael Caine), whose reputation was ruined after his last contestant criticized his methods, teaches the tomboyish Gracie how to dress, walk, and act like a contestant. She is not used to such behavior, however, and sees the pageant and its participants as \"antifeminist \". Eventually though Victor and Gracie come to respect each other's strengths. Representing New Jersey as \"Gracie Lou Freebush\", Gracie impresses the audience by playing the glass harp and demonstrating self-defense techniques during the talent competition. She also unexpectedly becomes friends with the other contestants, in particular Miss Rhode Island, Cheryl Frasier (Heather Burns) Several suspects emerge, including the corrupt competition director and former pageant winner Kathy Morningside (Candice Bergen); her unpleasant assistant Frank Tobin (Steve Monroe); the veteran pageant MC Stan Fields (William Shatner) who, like Kathy, is being replaced with a younger person; and last but not least Cheryl, who appears to have a history as a radical animal rights activist. While Gracie takes Cheryl and some of the other girls out partying, in an attempt to seek out more information about Cheryl's past through \"girl talk\", The Citizen is arrested elsewhere on an unrelated charge. After hearing what some of the other contestants said about Kathy Morningside's past (she won the pageant only after the original winner \"mysteriously\" contracted food poisoning), Gracie begins to suspect her, and is worried about the safety of the girls. Her boss thinks that her suspicions are groundless and that the pageant is out of danger now that the Citizen has been arrested. He calls off the mission. Gracie opts to turn in her badge and gun and continue the investigation alone. Eric initially fails to support Gracie and is about to return to the bureau when he figures out that Gracie's suspicions must be correct, and returns to help her. In the final round of the pageant, Gracie earns 1st Runner up while Cheryl becomes Miss United States. Gracie realizes that Kathy Morningside and Frank Tobin unknown to anyone (except Victor) is Kathy's son impersonated \"The Citizen\" and made the threat. Because she was going to be fired after the pageant was over, Kathy and her son were planning to murder the newly crowned pageant winner on stage by putting an explosive device in her", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}172{"query": "In 1959, Michael Courtland (Robertson), a New Orleans real estate developer, has his life shattered when his wife Elizabeth (Bujold) and young daughter Amy are kidnapped. The police recommend that he provide the kidnappers with a briefcase of shredded blank paper instead of the demanded ransom, as the kidnappers will then be more likely to surrender when cornered, rather than attempt to escape with cash in hand. Courtland agrees to this plan. This leads to a bungled car chase in which both kidnappers and victims are killed in a spectacular explosion. Courtland blames himself for the deaths of his wife and daughter. Fifteen years pass. Courtland is morbidly obsessed with his dead wife, and regularly visits a monument he has had built in her memory. The monument is a replica of the church (Basilica di San Miniato al Monte) where he and Elizabeth had met many years before in Florence, Italy. His real estate partner Robert LaSalle (Lithgow) convinces Courtland to tag along on a business trip back to Florence. While there, Courtland revisits the church, and suddenly comes face to face with a young woman named Sandra (Bujold) who looks exactly like his late wife. The already slightly unhinged Courtland begins to court the young woman, and subtly attempts to transform her into a perfect mirror image of his dead wife. Courtland returns to New Orleans with Sandra so they can marry. On their wedding night, Sandra is kidnapped and a ransom note is left behind by her abductors. It is an exact replica of the kidnappers' message from fifteen years before. This time, Courtland decides to deliver the demanded cash. He withdraws massive quantities of money from his accounts and business holdings, financially ruining him and forcing him to sign over his interest in the real estate business to LaSalle. In the process, he discovers that his entire ordeal, including the original kidnapping, had been engineered by LaSalle as a way to gain sole control of Courtland's company share holdings. The now nearly insane Courtland stabs LaSalle to death. Knowing that Sandra must have been a willing accomplice in the plot against him, he goes to the airport to kill the escaping woman. On the plane, Sandra has a flashback to her part in the scheme; she is in fact Courtland's daughter: following the original kidnapping LaSalle concealed her survival and sent her to live in secret with an Italian caretaker. Over the years, LaSalle has told her lies about Courtland, convincing her that her father had not paid the ransom because he didn't love her. Sandra, who has come to love Courtland, attempts suicide on the plane and is taken off the flight in a wheelchair. Courtland sees her and runs toward her, gun drawn. A security guard attempts to stop him but Courtland smashes the briefcase full of money against the guard's head, knocking him unconscious. The briefcase breaks open and all of the money flies out. Sandra, seeing the fluttering bills, stands up and shouts: \"Daddy! You brought the money!\" Courtland now realizes for the first time who Sandra really is, and father and daughter fall into a deep embrace.", "pos": "(Because the film has a very complicated plot and features many characters, the events will be told mostly in chronological order to render the plot clearer, rather than strictly adhering to the order we see in the film.)General Sternwood has two daughters: the elder one is Vivian (Lauren Bacall) and the younger one is Carmen, who is a carefree, childish and problematic young woman.General Sternwood has a man named Sean Regan working for him. With the help of Sean, the general has made a man named Joe Brody leave Carmen alone, by giving him 5.000 Dollars.Carmen loves Sean but Sean loves the wife of a man named Eddie Mars, so he refuses Carmens advances. One day, Carmen kills Sean when she is drunk because of her unrequited love. Eddie hides Seans body. He then makes up the story that Sean and his wife have run away together and nobody sees Sean after that day. To support this story, he actually makes his own wife go away and start living in a remote place. Even the general doesnt know Seans whereabouts and wonders why he has left all of a sudden. Eddie then proceeds to blackmail Vivian for Carmens murder. As a way of eliciting money from Vivian, Eddie makes her win big money at his gambling house with cheats, and then he takes all the money from her.Carmens troublesome adventures are not over, though. A man named Arthur Gwynn Geiger blackmails General Sternwood to take the gambling debts of Carmen. The general hires Philip Marlowe (Humphrey Bogart) to get rid of Geigers blackmail. Vivian talks to Marlowe, thinking that her father has actually hired him to find Sean Regan. Afraid that Carmen may get into trouble, she tries to take words from Marlowes mouth about his inquiry. But she learns that her father has not actually hired Marlowe about Sean.Marlowe goes to Geigers so-called antique books shop and sees a woman named Agnes, who makes it impossible for him to talk to Geiger. Then Marlowe waits at the bookshop across the street until the evening and follows Geiger and his right arm Carol Lundgren to Geigers house. Before Marlowe gets in the house, however, important things happen. Owen Taylor, driver for the Sternwoods, is in love with Carmen. He goes to Geigers house with her and kills Geiger for her. A secret camera, however, takes Carmens photo just at the moment of the murder. Owen then takes the film from the hidden camera, gets in the car and goes away. Joe Brody, also present that night, follows Owen, takes the film from him to blackmail Carmen, (and most probably) kills Owen and pushes his car in the water.When Marlowe gets in Geigers house, he sees Carmen with the dead body of Gaiger lying on the ground. Marlowe takes Carmen home and tells Vivian to say that Carmen has been home all night if asked by anyone. When he goes back to Geigers house, he sees that his dead body has been taken away.Later, Owens dead body is found in the car in the water. He has been killed before falling into the water. Marlowe learns from Vivian that Owen was interested in Carmen. Vivian then tells Marlowe that somebody is blackmailing her for Carmens photo taken at the night of Geigers murder. The blackmailer, who wants 5.000 Dollars, is actually Agnes. It is Joe Brody that makes her blackmail Vivian. Vivian tells Marlowe that she can take the money from Eddie.When Marlowe meets with Carmen once again at Geigers house, she tells him that it was Joe who took her photo that night. Eddie comes along and tries to scare Marlowe out of his inquiries.Later, Marlowe finds Joe Brody and questions him about Geiger. Agnes and Vivian are also at his house. Carmen comes along with a gun and threatens to kill Joe if he doesnt give her the photo. Carmen takes the photo and she leaves with Vivian. Then the doorbell rings again and somebody kills Joe, then escapes. Marlowe catches the man, who turns out to be Carol (Geigers right arm), who thinks that it was Joe who killed Geiger. Marlowe and Carol then go to", "neg": "Newspaper columnist John Klein (Richard Gere) and his wife Mary (Debra Messing) are involved in an accident when Mary swerves to avoid a black, flying figure. John survives the crash unscathed, but Mary is hospitalized. After Mary dies of an unrelated brain tumor, John discovers mysterious drawings of the creature that she had created prior to the night of the accident. Two years later, John becomes lost in West Virginia and inexplicably finds himself in Point Pleasant, hundreds of miles off his route. Driving in the middle of the night, his car breaks down; and he walks to a nearby house to get help. The owner, Gordon Smallwood (Will Patton), reacts violently to John's appearance and holds him at gunpoint. Local police officer Connie Mills (Laura Linney) defuses the situation while Gordon explains that this is the third consecutive night John has knocked on his door asking to use a phone, much to John's confusion. John stays at a local motel and considers how he ended up so far from his original destination. Officer Mills mentions to John that many strange things have been occurring in the past few weeks and that people report seeing a large winged creature like a giant moth with red eyes. She also tells John about a strange dream she had, in which the words \"Wake up, Number 37\" were spoken to her. While conversing with Gordon one day, it is revealed to John that he had heard voices from his sink telling him that, in Denver, \"99 will die\". While discussing the day's events at a local diner, John notices that the news is showing a story on an airplane crash in Denver that killed all 99 passengers aboard. The next night, Gordon frantically explains that he had met the voices in his head, a being named Indrid Cold Later that night, Gordon calls John and says that he is standing with a character named Indrid Cold. While John keeps Cold on the line, Officer Mills checks on Gordon. Cold answers John's questions, convincing him that he is a supernatural being. This episode starts a string of supernatural calls to John's motel room. One tells him that there will be a great tragedy on the Ohio River. Later, John receives a call from Gordon and rushes to his home to check on him. He finds Gordon outside, dead from exposure. John becomes obsessed with the being, dubbed Mothman. He meets an expert on the subject, Alexander Leek (Alan Bates), who explains its nature and discourages John from becoming further involved. However, when John learns the governor (Murphy Dunne) plans to tour a chemical plant located on the Ohio River the following day, he becomes convinced the tragedy will occur there. Officer Mills and the governor ignore his warnings, and nothing happens during the tour. Soon afterwards, John receives a mysterious message that instructs him to await a call from his deceased wife Mary back in Georgetown, and he returns home. On Christmas Eve, Officer Mills calls and convinces him to ignore the phone call from \"Mary\", return to Point Pleasant, and join her. Though anguished, John agrees. As John reaches the Silver Bridge, a malfunctioning traffic light causes traffic congestion. As John walks onto the bridge to investigate, the bolts and supports of the bridge strain. The bridge comes apart, and John realizes that the prophesied tragedy on the Ohio River was about the bridge. As the bridge collapses, Officer Mills's car falls into the water. John jumps in after her and pulls her from the river and up to safety. As the two sit on the back of an ambulance, they see that 36 people have been killed, making Connie the \"number 37\" from her dream. The epilogue displays a series of graphics that state the cause of the bridge collapse was never fully determined. It also states that, although the Mothman has been sighted in other parts of the world, it was never seen again in Point Pleasant.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}173{"query": "The interpretation of non-coding variants still constitutes a major challenge in the application of whole-genome sequencing in Mendelian disease, especially for single-nucleotide and other small non-coding variants. Here we present Genomiser, an analysis framework that is able not only to score the relevance of variation in the non-coding genome, but also to associate regulatory variants to specific Mendelian diseases. Genomiser scores variants through either existing methods such as CADD or a bespoke machine learning method and combines these with allele frequency, regulatory sequences, chromosomal topological domains, and phenotypic relevance todiscover variants associated to specific Mendelian disorders. Overall, Genomiser is able to identify causal regulatory variants as thetop candidate in 77% of simulated whole genomes, allowing effective detection and discovery of regulatory variants in Mendelian disease.", "pos": "In cancer research, background models for mutation rates have been extensively calibrated in coding regions, leading to the identification of many driver genes, recurrently mutated more than expected. Noncoding regions are also associated with disease; however, background models for them have not been investigated in as much detail. This is partially due to limited noncoding functional annotation. Also, great mutation heterogeneity and potential correlations between neighboring sites give rise to substantial overdispersion in mutation count, resulting in problematic background rate estimation. Here, we address these issues with a new computational framework called LARVA. It integrates variants with a comprehensive set of noncoding functional elements, modeling the mutation counts of the elements with a -binomial distribution to handle overdispersion. LARVA, moreover, uses regional genomic features such as replication timing to better estimate local mutation rates and mutational hotspots. We demonstrate LARVA's effectiveness on 760 whole-genome tumor sequences, showing that it identifies well-known noncoding drivers, such as mutations in the TERT promoter. Furthermore, LARVA highlights several novel highly mutated regulatory sites that could potentially be noncoding drivers. We make LARVA available as a software tool and release our highly mutated annotations as an online resource (larva.gersteinlab.org).", "neg": "The complex expression patterns observed for many genes are often regulated by distal transcription enhancers. Changes in the nucleotide sequences of enhancers may therefore lead to changes in gene expression, representing a central mechanism by which organisms evolve. With the development of the experimental technique of chromatin immunoprecipitation (ChIP), in which discrete regions of the genome bound by specific proteins can be identified, it is now possible to identify transcription factor binding events (putative cis-regulatory elements) in entire genomes. Comparing protein-DNA binding maps allows us, for the first time, to attempt to identify regulatory differences and infer global patterns of change in gene expression across species. Here, we review studies that used genome-wide ChIP to study the evolution of enhancers. The trend is one of high divergence of cis-regulatory elements between species, possibly compensated by extensive creation and loss of regulatory elements and rewiring of their target genes. We speculate on the meaning of the differences observed and discuss that although ChIP experiments identify the biochemical event of protein-DNA interaction, it cannot determine whether the event results in a biological function, and therefore more studies are required to establish the effect of divergence of binding events on species-specific gene expression.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}174{"query": "Assume that a school bus, like the one in Figure 12.2, passes by as you stand on the sidewalk. Its obvious to you that the bus is moving. It is moving relative to you and the trees across the street. But what about to the children inside the bus? They arent moving relative to each other. If they look only at the other children sitting near them, they will not appear to be moving. They may only be able to tell that the bus is moving by looking out the window and seeing you and the trees whizzing by. This example shows that how we perceive motion depends on our frame of reference. Frame of reference refers to something that is not moving with respect to an observer that can be used to detect motion. For the children on the bus, if they use other children riding the bus as their frame of reference, they do not appear to be moving. But if they use objects outside the bus as their frame of reference, they can tell they are moving. What is your frame of reference if you are standing on the sidewalk and see the bus go by? How can you tell the bus is moving? The video at the URL below illustrates other examples of how frame of reference is related to motion. MEDIA Click image to the left or use the URL below. URL: Did you ever go to a track meet like the one pictured in Figure 12.3? Running events in track include 100-meter sprints and 2000-meter races. Races are named for their distance. Distance is the length of the route between two points. The length of the route in a race is the distance between the starting and finishing lines. In a 100-meter sprint, for example, the distance is 100 meters. The SI unit for distance is the meter (1 m = 3.28 ft). Short distances may be measured in centimeters (1 cm = 0.01 m). Long distances may be measured in kilometers (1 km = 1000 m). For example, you might measure the distance a frogs tongue moves in centimeters and the distance a cheetah moves in kilometers. Maps can often be used to measure distance. Look at the map in Figure 12.4. Find Mias house and the school. You can use the map key to directly measure the distance between these two points. The distance is 2 kilometers. Measure it yourself to see if you agree. Things dont always move in straight lines like the route from Mias house to the school. Sometimes they change direction as they move. For example, the route from Mias house to the post office changes from west to north at the school (see Figure 12.4). To find the total distance of a route that changes direction, you must add up the distances traveled in each direction. From Mias house to the school, for example, the distance is 2 kilometers. From the school to the post office, the distance is 1 kilometer. Therefore, the total distance from Mias house to the post office is 3 kilometers. You Try It! Problem: What is the distance from the post office to the park in Figure 12.4? Direction is just as important as distance in describing motion. For example, if Mia told a friend how to reach the post office from her house, she couldnt just say, \"go 3 kilometers.\" The friend might end up at the park instead of the post office. Mia would have to be more specific. She could say, \"go west for 2 kilometers and then go north for 1 kilometer.\" When both distance and direction are considered, motion is a vector. A vector is a quantity that includes both size and direction. A vector is represented by an arrow. The length of the arrow represents distance. The way the arrow points shows direction. The red arrows in Figure 12.4 are vectors for Mias route to the school and post office. If you want to learn more about vectors, watch the videos at these URLs: (5:27) MEDIA Click image to the left or use the URL below. URL: You Try It! Problem: Draw vectors to", "pos": "Speed is an important aspect of motion. It is a measure of how fast or slow something moves. It depends on how far something travels and how long it takes to travel that far. Speed can be calculated using this general formula: speed = distance time A familiar example is the speed of a car. In the U.S., this is usually expressed in miles per hour (see Figure 12.6). If your family makes a car trip that covers 120 miles and takes 3 hours, then the cars speed is: speed = 120 mi = 40 mi/h 3h The speed of a car may also be expressed in kilometers per hour (km/h). The SI unit for speed is meters per second (m/s). When you travel by car, you usually dont move at a constant speed. Instead you go faster or slower depending on speed limits, traffic, traffic lights, and many other factors. For example, you might travel 65 miles per hour on a highway but only 20 miles per hour on a city street (see Figure 12.7). You might come to a complete stop at traffic lights, slow down as you turn corners, and speed up to pass other cars. The speed of a moving car or other object at a given instant is called its instantaneous speed. It may vary from moment to moment, so it is hard to calculate. Its easier to calculate the average speed of a moving object than the instantaneous speed. The average speed is the total distance traveled divided by the total time it took to travel that distance. To calculate the average speed, you can use the general formula for speed that was given above. Suppose, for example, that you took a 75-mile car trip with your family. Your instantaneous speed would vary throughout the trip. If the trip took a total of 1.5 hours, your average speed for the trip would be: average speed = 75 mi = 50 mi/h 1.5 h You can see a video about instantaneous and average speed and how to calculate them at this URL: MEDIA Click image to the left or use the URL below. URL: You Try It! Problem: Terri rode her bike very slowly to the top of a big hill. Then she coasted back down the hill at a much faster speed. The distance from the bottom to the top of the hill is 3 kilometers. It took Terri 15 minutes to make the round trip. What was her average speed for the entire trip? The motion of an object can be represented by a distance-time graph like the one in Figure 12.8. A distance-time graph shows how the distance from the starting point changes over time. The graph in Figure 12.8 represents a bike trip. The trip began at 7:30 AM (A) and ended at 12:30 PM (F). The rider traveled from the starting point to a destination and then returned to the starting point again. In a distance-time graph, the speed of the object is represented by the slope, or steepness, of the graph line. If the line is straight, like the line between A and B in Figure 12.8, then the speed is constant. The average speed can be calculated from the graph. The change in distance (represented by Dd) divided by the change in time (represented by Dt): speed = Dd Dt For example, the speed between A and B in Figure 12.8 is: speed = Dd 20 km 0 km 20 km = = = 20 km/h Dt 8:30 7:30 h 1h If the graph line is horizontal, as it is between B and C, then the slope and the speed are zero: speed = Dd 20 km 20 km 0 km = = = 0 km/h Dt 9:00 8:30 h 0.5 h You Try It! Problem: In Figure 12.8, calculate the speed of the rider between C and D. If you know the speed of a moving object, you can also calculate the distance it will travel in a given amount of time. To do so, you would use this version of the general speed formula:", "neg": "With the new school year quickly coming near (or perhaps, for your early-starters, already under way), it's time to get ready for a successful term . And while you may be cleaning your wardrobe , it's equally important to freshen up your study skills, too. Have you ever noticed that your study habits are different from those of your friends? Or how you seem to learn faster in certain classes? Some people are quick to blame the teacher or subject for their difficulties, but that isn't always the cause . One thing that many people seem to ignore is their learning type. Now, you may be wondering what a learning type is and how to find yours. There are three different learning types: Visual, Auditory, and Kinesthetic. You can be a _ of learning types, but most people have one main type. 1. Visual learners learn best by seeing. If you seem to easily get information from pictures, graphs, and videos, you are likely a visual learner. 2. Auditory learners learn best by hearing. If you seem to remember things by hearing them, whether listening to a lecture or repeating information out loud, then you are likely an auditory learner. 3. Kinesthetic learners learn best by doing. If you seem to learn best by working with your hands or testing out what you are shown, you are likely a kinesthetic learner. So now that you know your personal learning style, the trick is to find out how to use your new-found knowledge to help you in your classes.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}175{"query": "On 24 July 1867, a part of the territory of Bagnolet was detached and merged with a part of the territory of Romainville and a part of the territory of Pantin to create the commune of Les Lilas.", "pos": "On 7 July 1899, a part of the territory of Villiers-sur-Marne was detached and merged with a part of the territory of La Queue-en-Brie and a part of the territory of Chennevieres-sur-Marne to create the commune of Le Plessis-Trevise.", "neg": "The Oude Maasje (''Little Old Meuse'') is a former distributary of the river Maas (or Meuse), which runs parallel to the current canalised Bergse Maas.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}176{"query": "Heat moves in the atmosphere the same way it moves through the solid Earth or another medium. What follows is a review of the way heat flows, but applied to the atmosphere. Radiation is the transfer of energy between two objects by electromagnetic waves. Heat radiates from the ground into the lower atmosphere. In conduction, heat moves from areas of more heat to areas of less heat by direct contact. Warmer molecules vibrate rapidly and collide with other nearby molecules, transferring their energy. In the atmosphere, conduction is more effective at lower altitudes, where air density is higher. This transfers heat upward to where the molecules are spread further apart or transfers heat laterally from a warmer to a cooler spot, where the molecules are moving less vigorously. Heat transfer by movement of heated materials is called convection. Heat that radiates from the ground initiates convection cells in the atmosphere (Figure 1.1). Click image to the left or use the URL below. URL: Different parts of the Earth receive different amounts of solar radiation. Which part of the planet receives the most solar radiation? The Suns rays strike the surface most directly at the Equator. The difference in solar energy received at different latitudes drives atmospheric circulation.", "pos": "The Sun is Earths main source of energy. The Sun gives us both light and heat. The Sun changes hydrogen into helium through nuclear fusion. This releases huge amounts of energy. The energy travels to the Earth mostly as visible light. The energy is carried through the empty space by radiation. We can use sunlight as an energy resource, called solar energy (Figure 5.7). Solar energy has been used on a small scale for hundreds of years. Today we are using solar energy for more of our power demands. Solar power plants are being built in many locations around the world. In the United States, the southwestern deserts are well suited for solar plants. Sunlight is turned into electricity at a solar power plant. These power plants use a large group of mirrors to focus sunlight on one place. This place is called a receiver (Figure 5.8). At the receiver, a liquid such as oil or water is heated to a high temperature. The liquid transfers its heat by conduction. In conduction, energy moves between two objects that are in contact. The higher temperature object transfers heat to the lower temperature object. For example, when you heat a pot of water on a stove top, energy moves from the pot to its metal handle by conduction. At a solar power plant, the energy conducted by the heated liquid is used to make electricity. Solar energy is used to heat homes and water, and to make electricity. Scientists and engineers have many ways to get energy from the Sun (Figure 5.9). One is by using solar cells. Solar cells are devices that turn sunlight directly into electricity. Lots of solar cells make up an individual solar panel. You may have seen solar panels on roof tops. The Suns heat can also be trapped in your home by using south facing windows and good insulation. Solar energy has many benefits. It does not produce any pollution. There is plenty of it available, much more than we could possibly use. But solar energy has problems. The Sun doesnt shine at night. A special battery is needed to store extra energy during the day for use at night. The technology for most uses of solar energy is still expensive. Until solar technology becomes more affordable, most people will prefer to get their energy from other sources. Moving water has energy (Figure 5.10). That energy is used to make electricity. Hydroelectric power harnesses the energy of water moving down a stream. Hydropower is the most widely used form of renewable energy in the world. This abundant energy source provides almost one fifth of the worlds electricity. The energy of waves and tides can also be used to produce water power. At this time, wave and tidal power are rare. To harness water power, a stream must be dammed. Narrow valleys are the best for dams. While sitting in the reservoir behind the dam, the water has potential energy. Water is allowed to flow downhill into a large turbine. While flowing downhill, the water has kinetic energy. Kinetic energy makes the turbine spin. The turbine is connected to a generator, which makes electricity. Many of the suitable streams in the United States have been developed for hydroelectric power. Many streams worldwide also have hydroelectric plants. Hydropower is a major source of Californias electricity. It accounts for about 14.5 percent of the total. Most of Californias nearly 400 hydroelectric power plants are located in the Sierra Nevada mountains. Water power does not burn a fuel. So it causes less pollution than many other kinds of energy. Water power is also a renewable resource. Water keeps flowing downhill. Although we use some of the energy from this movement, we are not using up the water. Water power does have problems. A large dam stops a streams flow, which floods the land upstream. A beautiful location may be lost. People may be displaced. The dams and turbines also change the downstream environment. Fish and other living things may not be able to survive. Dams slow the release of silt. Downstream deltas retreat and beaches may be starved of sand. Seaside cities may become exposed to storms and", "neg": "Air temperature changes as altitude increases. In some layers of the atmosphere, the temperature decreases. In other layers, it increases. You can see this in Figure 15.12. Refer to this figure as you read about the layers below. The troposphere is the lowest layer of the atmosphere. In it, temperature decreases with altitude. The troposphere gets some of its heat directly from the Sun. Most, however, comes from Earths surface. The surface is heated by the Sun and some of that heat radiates back into the air. This makes the temperature higher near the surface than at higher altitudes. Look at the troposphere in Figure 15.12. This is the shortest layer of the atmosphere. It rises to only about 12 kilometers (7 miles) above the surface. Even so, this layer holds 75 percent of all the gas molecules in the atmosphere. Thats because the air is densest in this layer. Air in the troposphere is warmer closer to Earths surface. Warm air is less dense than cool air, so it rises higher in the troposphere. This starts a convection cell. Convection mixes the air in the troposphere. Rising air is also a main cause of weather. All of Earths weather takes place in the troposphere. Sometimes air doesnt mix in the troposphere. This happens when air is cooler close to the ground than it is above. The cool air is dense, so it stays near the ground. This is called a temperature inversion. An inversion can trap air pollution near the surface. Temperature inversions are more common in the winter. Can you explain why? At the top of the troposphere is a thin layer of air called the tropopause. You can see it in Figure 15.12. This layer acts as a barrier. It prevents cool air in the troposphere from mixing with warm air in the stratosphere. The stratosphere is the layer above the troposphere. The layer rises to about 50 kilometers (31 miles) above the surface. Air temperature in the stratosphere layer increases with altitude. Why? The stratosphere gets most of its heat from the Sun. Therefore, its warmer closer to the Sun. The air at the bottom of the stratosphere is cold. The cold air is dense, so it doesnt rise. As a result, there is little mixing of air in this layer. The stratosphere contains a layer of ozone gas. Ozone consists of three oxygen atoms (O3 ). The ozone layer absorbs high-energy UV radiation. As you can see in Figure 15.14, UV radiation splits the ozone molecule. The split creates an oxygen molecule (O2 ) and an oxygen atom (O). This split releases heat that warms the stratosphere. By absorbing UV radiation, ozone also protects Earths surface. UV radiation would harm living things without the ozone layer. At the top of the stratosphere is a thin layer called the stratopause. It acts as a boundary between the stratosphere and the mesosphere. The mesosphere is the layer above the stratosphere. It rises to about 85 kilometers (53 miles) above the surface. Temperature decreases with altitude in this layer. There are very few gas molecules in the mesosphere. This means that there is little matter to absorb the Suns rays and heat the air. Most of the heat that enters the mesosphere comes from the stratosphere below. Thats why the mesosphere is warmest at the bottom. Did you ever see a meteor shower, like the one in Figure 15.15? Meteors burn as they fall through the mesosphere. The space rocks experience friction with the gas molecules. The friction makes the meteors get very hot. Many meteors burn up completely in the mesosphere. At the top of the mesosphere is the mesopause. Temperatures here are colder than anywhere else in the atmosphere. They are as low as -100 C (-212 F)! Nowhere on Earths surface is that cold. The thermosphere is the layer above the mesosphere. It rises to 600 kilometers (372 miles) above the surface. The International Space Station orbits Earth in this layer as in Figure 15.16. Temperature increases with altitude in the thermosphere. Surprisingly,", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}177{"query": "Marco Solfrini (born 30 January 1958 in Brescia) is a former basketball player from Italy, who won the silver medal with his national team at the 1980 Summer Olympics in Moscow.", "pos": "Branko Cvetkovic (born 5 March 1984) is a Serbian professional basketball player for Tadamon Zouk of the Lebanese Basketball League.", "neg": "Mira Bjedov, married Nikolic, (born 7 September 1955 in Mokro Polje) is a former basketball player who competed for Yugoslavia in the 1980 Summer Olympics.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}178{"query": "After a tough win over the Texans, the Steelers stayed home for a game against the Colts. In the first quarter, the Colts scored first as Adam Vinatieri nailed a 31-yard field goal for a 3-0 lead. However, the Steelers took the lead later on in the quarter when Ben Roethlisberger found Markus Wheaton on an 18-yard TD pass for a 7-3 game. In the 2nd quarter, the Steelers would score again increasing their lead as Roethlisberger found Martavis Bryant on a 5-yard TD pass for a 14-3 game. This was followed by William Gay picking off Andrew Luck and returning it 33 yards for a TD as they increased their lead to 21-3. The Colts however responded as Andrew Luck threw a 21-yard TD pass to Dwayne Allen for a 21-10 game. However, the Steelers pulled away as Roethlisberger would find Antonio Brown on 2 consecutive TD passes: from 8 and 47 yards out to increase their lead at first from 28-10 to 35-10. The Colts responded with 10 straight points first being Luck who found T. Y. Hilton on a 28-yard TD Pass for a 35-17 game followed by Vinatieri kicking a 23-yard field goal before halftime to make the score 35-20. The Steelers went back to work in the 3rd quarter as Roethlisberger and Bryant hooked up again on a 2-yard TD pass to increase their lead making the score 42-20. The Colts however were able to come within 8 later on when Ahmad Bradshaw ran for a 12-yard TD followed by Luck finding Donte Moncrief on a 31-yard TD pass to make the score 42-27 and then 42-34. In the 4th quarter, it was all Steelers when a penalty was enforced on Luck in the end zone for a safety making the score 44-34. The Steelers were able to seal the game later on when Roethlisberger found Heath Miller on an 11-yard TD pass for a final score of 51-34. Roethlisberger set franchise records with 522 yards passing and six touchdowns while picking up his 100th victory in his 150th start. Roethlisberger's yardage total was the fourth highest in NFL history. He became the first player in NFL history to go over 500 yards passing twice as the Steelers won consecutive games for the first time this season.", "pos": "Following their victory over the Patriots, the Steelers remained at home the next week for their second match-up of the season against division rivals the Baltimore Ravens. The Ravens scored first with an 18-yard field goal by kicker Billy Cundiff, the only points scored in the first quarter by either team. Steelers kicker Shaun Suisham answered with a 36-yard field goal early in the second quarter, and a 30-yard field goal near the end, but both of these were quickly matched by Baltimore's Cundiff with a 43-yard and 51-yard field goal, respectively, giving Baltimore a 9-6 lead at halftime. The Ravens then increased their lead in the third quarter when Ray Rice scored the first touchdown of the game on a 4-yard run. The Steelers rallied hard in the fourth quarter, with running back Rashard Mendenhall making a 1-yard run to score a touchdown, and then taking the lead for the first time in the game when quarterback Ben Roethlisberger made a successful 25-yard pass to wide receiver Mike Wallace in the endzone for a second touchdown. On their final drive of the game, the Steelers were ready to potentially increase their lead with a 47-yard field goal kick by Shaun Suisham, but a 5-yard delay of game penalty put them out of field goal range and they were instead forced to punt the ball to the Ravens. The Ravens then began a 92-yard drive, culminating in a 26-yard touchdown pass by quarterback Joe Flacco to wide receiver Torrey Smith in the endzone with just 8 seconds remaining, giving them the game.", "neg": "The Steelers' ninth game was an AFC duel with the Patriots. The Steelers trailed early as QB Tom Brady made a 19-yard TD pass to TE Rob Gronkowski. This was followed by kicker Shayne Graham getting a 31-yard field goal. The Steelers responded in the second quarter with kicker Jeff Reed nailing a 22-yard field goal. The Steelers struggled further when Brady threw another TD pass to Gronkowski, this one from 9yards out. That was followed by Brady's scramble 3yards to the endzone for a touchdown (With a failed PAT as the kick went wide-right). The Steelers scored first in the 4th quarter when QB Ben Roethlisberger completed a 6-yard TD pass to WR Emmanuel Sanders. The Steelers looked to create another scoring drive, but it came to a halt when Roethlisberger's pass was intercepted by SS James Sanders and returned 32yards for a touchdown (With a failed 2-point conversion). The Steelers tried to cut the lead with a Roethlisberger 15-yard TD pass to WR Mike Wallace, but the Patriots replied with Brady getting a 25-yard TD pass to Gronkowski. Again the Steelers tried to get closer when Roethlisberger completed a 33-yard TD pass to Wallace, but the Patriots put the game away after Graham hit a 36-yard field goal.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}179{"query": "Karen L. Parker, the first African-American woman undergraduate to attend the University of North Carolina at Chapel Hill, was born in Salisbury, North Carolina and grew up in Winston-Salem, North Carolina.", "pos": "Joy Tivy was born in Carlow, Ireland in 1924 and she commenced studies at the University College Dublin in 1942 where she studied geography as her primary subject with botany and geology as her secondary areas.", "neg": "Isias was the daughter of King Ariobarzanes I of Cappadocia and his wife Queen Athenais Philostorgos I, while her brother was King Ariobarzanes II of Cappadocia.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}180{"query": "Finally, in 2001, SV Nord-Nordstern and SC Wedding-Rapide came together to form SV Nord Wedding 1893.", "pos": "The Reichswehr (English: Empire Defence) formed the military organization of Germany from 1919 until 1935, when it was united with the newly founded Wehrmacht (''Defence Force'').", "neg": "In 1998, W.H. Brady Co. became Brady Corporation and in 1999, the company began trading on the New York Stock Exchange under ticker symbol BRC.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}181{"query": "With headquarters in Elswick, Newcastle upon Tyne, Armstrong Whitworth engaged in the construction of armaments, ships, locomotives, automobiles, and aircraft.", "pos": "Sharp, Stewart and Company was a steam locomotive manufacturer, initially based in Manchester, England.", "neg": "JSC NMZ or Nizhny Novgorod Machine-building Plant (Russian: or All-Union Machine-building Plant New Sormovo Russian: '' '', Joseph Stalin Factory No. 92, Zavod imeni Stalina, or ZiS) was a Soviet artillery factory in the Sormovo district of Gorky.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}182{"query": "Jochebed's position in the family tree of Gershon is uncertain.", "pos": "In the published version of The Silmarillion, Orodreth (IPA: (orodre)) was an Elf of the First Age, the second son of Finarfin (with Finrod Felagund, Angrod, Aegnor, and Galadriel being his siblings), and a ruler of Nargothrond.", "neg": "Sir John's considerable wealth in Barbados passed to his son, Major Sir William Yeamans, second baronet, and great-grandfather of Sir John Yeamans of Barbados, whose son, Sir Robert (d. 19 February 1788), was the last baronet.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}183{"query": "Greenwich is on the River, five miles from the middle of London, and its history is two thousand years old. The first English people were fishermen there, and they named the place Greenwich, meaning \"green village\". Later the English kings and queens lived at Greenwich in their beautiful places. The name of the earliest palace was Placentia. Henry VIII lived there. He knew that England must be strong at sea. So he started two big ship-yards at Greenwich. But trouble was coming to Greenwich. In 1649, a war started in England and for eleven years there was no king. The men who had worked for him at Placentia decided to live the place themselves. They sold all its beautiful things. Finally, the war ended and King Charles II came back. But Placentia was falling down. So King Charles built a new and bigger palace, which is now open to the public. At this time, Charles was worried about losing so many of its ships at sea: their sailors did not know how to tell exactly where they were. So in 1675, Charles made John Flamsteed, the first astronomer in England, try to find the answer. Flamsteed worked in a new building on the high ground in Greenwich Park. From it with a telescope which he made himself, Flamsteed could look all round the sky. And he did, night after night, for twenty years. Carrying on Flamsteed's work a hundred years later, an astronomer called Harrison finally made a clock which told the time at sea, and helped sailors to know where they were. You can see Harrison's clock, still working, in Greenwich's museum of the sea. Because of Flamsteed's work, every country in the world now tells its time by Greenwich Time.", "pos": "In olden times, England is in turmoil. With the death of the King, noone can decide who is the rightful heir to the throne. With war threatening to tear the country asunder, a stone and anvil appear from the heavens in London town, with a sword planted firmly in the anvil. On the hilt of the sword, read the words, \"Whoso pulleth out this sword of this stone and anvil is rightwise king, born of England.\" Many try to pull the sword, but none can budge it. In time, the sword is forgotten, and the Dark Ages plunge the countryside into a dismal state.Out in the woods one day, Sir Kaye is out hunting with his adopted brother Arthur, whom everyone names 'Wart.' After causing Kaye to miss shooting a deer, Arthur promises to retrieve the arrow. Arthur's journey leads him to a small hut, wherein resides a sorcerer named Merlin, and his pet owl, Archimedes, who can talk. Merlin explains to Arthur that he was expecting him to appear. After they have tea, Merlin decides to accompany Arthur back to his home, and after packing up everything in the hut into a small satchel, the two set off.Arthur and Merlin arrive at the castle of Sir Ector, where Arthur is immediately put to work in the kitchen. Merlin introduces himself to Ector, and displays his powers to the doubting Knight. After some persuasion, Ector allows Merlin to stay, putting him up in the Northwest Tower, a crumbling edifice of the castle.A few days later, Archimedes observes the arrival of Sir Pelinore, who has brought news from London of a jousting tournament to Ector and Kaye. According to the rules, the winner of the tournament will become the new King of England. Ector eagerly begins to have Kaye train, and in his excitement, promises Arthur that if he keeps working hard at his duties, he can become Kaye's squire.Merlin hears of this news, and decides to push Arthur to see his true potential (as Merlin can move into the past and the future, he knows who Arthur will become). While walking outside along the castle's moat, Merlin explains that he can turn into a fish. This idea excites Arthur, and Merline turns them both into fish, to explore the moat. However, a much larger fish soon gives chase to young Arthur, until they both manage to escape.Arthur's tardiness in helping Kaye practice results in him washing dishes. Merlin finds him, and after bewitching the dishes and washing utensils, leads Arthur into the forest, where they both are turned into squirrels by the sorcerer. As Arthur leaps among the trees, he comes across a girl squirrel, who is soon madly infatuated with him. Merlin finds the whole scenario cute, until he is soon found irresistible by another squirrel. Merlin then changes himself and Arthur back to normal. The girl squirrel who was infatuated with Arthur, skitters away, heartbroken.Arthur and Merlin return to the castle, where Ector lectures Merlin for making Arthur shirk his duties. Arthur tries to defend Merlin, but his 'mouthing off' ends causes Ector to declare that Arthur will not become Kaye's squire, and that that honor will belong to another person of the castle, who is named Hobbes.Arthur is dejected at what has happened, but Merlin tries to get him to persevere, and plans to educate Arthur. As he attempts to explain things, Archimedes interjects on Merlin's teaching methods, as Merlin is educating Arthur on things that will not be proven for hundreds of years, and could very well lead people to think of Arthur as a raving lunatic in their current Dark Ages.Exasperated at this lecturing, Merlin turns teaching duties over to Archimedes, while he fiddles with a model plane. Archimedes scoffs at the toy plane, while Merlin attempts to prove that 'man will fly.' His efforts lead to the plane plummeting like a rock to the moat below. Even though the plane's flight was a failure, Arthur tells of how he's often dreamed of soaring like a bird. It is then that Merlin uses his", "neg": "The Green Revolution has brought enormous impacts to the planet. Natural landscapes have been altered to create farmland and cities. Already, half of the ice-free lands have been converted to human uses. Estimates are that by 2030, that number will be more than 70%. Forests and other landscapes have been cleared for farming or urban areas. Rivers have been dammed and the water is transported by canals for irrigation and domestic uses. Ecologically sensitive areas have been altered: wetlands are now drained and coastlines are developed. Modern agricultural practices produce a lot of pollution (Figure 1.1). Some pesticides are toxic. Dead zones grow as fertilizers drain off farmland and introduce nutrients into lakes and coastal areas. Farm machines and vehicles used to transport crops produce air pollutants. Pollutants enter the air, water, or are spilled onto the land. Moreover, many types of pollution easily move between air, water, and land. As a result, no location or organism not even polar bears in the remote Arctic is free from pollution. The increased numbers of people have other impacts on the planet. Humans do not just need food. They also need clean water, secure shelter, and a safe place for their wastes. These needs are met to different degrees in different nations and among different socioeconomic classes of people. For example, about 1.2 billion of the worlds people do not have enough clean water for drinking and washing each day (Figure 1.2). The addition of more people has not just resulted in more poor people. A large percentage of people expect much more than to have their basic needs met. For about one-quarter of people there is an abundance of food, plenty of water, and a secure home. Comfortable temperatures are made possible by heating and cooling systems, rapid trans- portation is available by motor vehicles or a well-developed public transportation system, instant communication takes place by phones and email, and many other luxuries are available that were not even dreamed of only a few The percentage of people in the world that live in abject poverty is decreasing some- what globally, but increasing in some re- gions, such as Sub-Saharan Africa. decades ago. All of these require resources in order to be produced, and fossil fuels in order to be powered (Figure Many people refer to the abundance of luxury items in these peoples lives as over-consumption. People in developed nations use 32 times more resources than people in the developing countries of the world. Click image to the left or use the URL below. URL: Click image to the left or use the URL below. URL:", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}184{"query": "I'm sure many of you have seen Star Wars, Jurassic Park, Multiplicity, or many of the other movies that describe cloning. Most of what you see in these movies is false. What you don't know is that cloning could be dangerous, to the clone and to our society as a whole. I think human cloning is wrong mainly for four reasons. What about identity? Humans are promised the right to their own personalities. What would happen if we ignore those rights by giving them someone else's genetic identity? True, Cloning may prevent people from possessing their identities. Also, these is a large power struggle here. Cloning means a degree of power and controls over another person's physical identity and that ignores their rights and their only personalities. The person doing the cloning would have more power than any parent would have. Cloning would also deal with killing embryos . You might not have known, but Dolly, the sheep that was cloned in 1996, was one of over 200 sheep embryos and hers was the only embryo that survived. The rest died or were thrown away. Imagine if the failure rate was that high when we started to clone humans. cloning means running the risk of wasting too much effort Cloning someone, at this present time, would be extremely dangerous to the birth mother and the clone. In studies done on cows, 4 out of 12 birth mothers died. There is a very high failure rate, which is shown in the cloning of Dolly. Even if you had a few good embryos, failures have been noticeable in animal tests. So, should we work ahead in the world of cloning? I say no. the risks are greater than the benefits. It's dangerous to the clone and to the birth mother. We would be killing human lives in the process. It would also be a violation of the clone's right to its own genetic identity and personality.", "pos": "Cloning is the process of creating an exact genetic replica of an organism. The clones DNA is exactly the same as the parents DNA. Bacteria and other single-celled organisms have long been able to clone themselves through asexual reproduction. Plants can also reproduce asexually. In animals, however, cloning does not happen naturally. In 1997, that all changed when a sheep named Dolly was the first large mammal ever to be successfully cloned. Other animals can now also be cloned in a laboratory. The process of producing an animal like Dolly starts with a single cell from the animal that is going to be cloned. Below are the steps involved in the process of cloning: 1. In the case of Dolly, cells from the mammary glands were taken from the adult that was to be cloned. But other somatic cells can be used. Somatic cells come from the body and are not gametes like sperm or egg. 2. The nucleus is removed from this cell. 3. The nucleus is placed in a donor egg that has had its nucleus removed. The nucleus must be removed from the donor egg to maintain the appropriate chromosome number. 4. The new cell is stimulated with an electric shock and embryo development begins, as if it were a normal zygote. The zygote is the first cell of a new organism. 5. The resulting embryo is implanted into a mother sheep, where it continue its development ( Figure 1.1). To clone an animal, a nucleus from the animals cells are fused with an egg cell (from which the nucleus has been re- moved) from a donor, creating a new zy- gote. Cloning is not always successful. Most of the time, this cloning process does not result in a healthy adult animal. The process has to be repeated many times until it works. In fact, 277 tries were needed to produce Dolly. This high failure rate is one reason that human cloning is banned in the United States. In order to produce a cloned human, many attempts would result in the surrogate mothers experiencing miscarriages, stillbirths, or deformities in the infant. There are also many additional ethical considerations related to human cloning. Can you think of reasons why people are for or against cloning?", "neg": "The genetic information of the cell, or DNA, is stored in the nucleus. During mitosis, two nuclei (plural for nucleus) must form, so that one nucleus can be in each of the new cells after the cell divides. In order to create two genetically identical nuclei, DNA inside of the nucleus must be copied or replicated. This occurs during the S phase of the cell cycle. During mitosis, the copied DNA is divided into two complete sets, so that after cytokinesis, each cell has a complete set of genetic instructions. To begin mitosis, the DNA in the nucleus wraps around proteins to form chromosomes. Each organism has a unique number of chromosomes. In human cells, our DNA is divided up into 23 pairs of chromosomes. Replicated DNA forms a chromosome made from two identical sister chromatids, forming an \"X\" shaped molecule ( Figure 1.1). The two chromatids are held together on the chromosome by the centromere. The centromere is also where spindle fiber microtubules attach during mitosis. The spindles separate sister chromatids from each other. During mitosis, the two sister chromatids must be divided. This is a precise process that has four individual phases to it. After the sister chromatids separate, each separate chromatid is now known as a chromosome. Each resulting chromosome is made of DNA from just one chromatid. So, each chromosome after this separation is made of \"1/2 of the X.\" Through this process, each daughter cell receives one copy of each chromosome. The four phases of mitosis are prophase, metaphase, anaphase and telophase ( Figure 1.2). 1. Prophase: The chromatin, which is unwound DNA, condenses forming chromosomes. The DNA becomes so tightly wound that you can see them under a microscope. The membrane around the nucleus, called the nuclear envelope, disappears. Spindles also form and attach to chromosomes to help them move. 2. Metaphase: The chromosomes line up in the center, or the equator, of the cell. The chromosomes line up in a row, one on top of the next. 3. Anaphase: The two sister chromatids of each chromosome separate as the spindles pull the chromatids apart, resulting in two sets of identical chromosomes. 4. Telophase: The spindle dissolves and nuclear envelopes form around the chromosomes in both cells. An overview of the cell cycle and mito- sis: during prophase the chromosomes condense, during metaphase the chromo- somes line up, during anaphase the sister chromatids are pulled to opposite sides of the cell, and during telophase the nuclear envelope forms. This is a representation of dividing plant cells. Cell division in plant cells differs slightly from animal cells as a cell wall must form. Note that most of the cells are in interphase. Can you find examples of the different stages of mitosis?", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}185{"query": "CNN news-Jan 16,2013 Protests have been going on for about a week now in the northern Irish capital of Belfast. They Started out peacefuily , bus some of them turn violent later on. There is a lot of history behind these protests,and it starts with geography, What's interesting is that Northern Ireland is not part of the republic of Iteland. It,s part of the United Kingdom, and that's what's behind this tension, Nationalists, mostly Catholic, think Northern Ireland should be part of the Republic of Ireland, Unionists, or Loyalists, mostly Protestants, wanted to stay part of the United Kingdom, The conflict between those two groups led to decades of violence ,and more than3,000 people were killed before a peace deal was signed in 1998,The protests happening now are connected to a decision regarding the British flahg ,In Belfast ,the capital of Northern Ireland ,the flag used to fly over City Halll every day of the year , Last month, local officials decided to limit that to 18 days per year. Unionists weren't happy about that . In some cases protesters have thrown concrete blocks, bricks, even weren't happy about that , In some cases protesters have thrown concrete blocks, bricks, even gasoline bombs at police ,Officers have responded by using water cannons to break up the protests. Nest up ,we are heading to the capital of China , Beijing, Experts say that city has something in common with Los Angeles; smog This gray haze is hanging in the air, making things hard to see ,Yesterday, the numbers indicating smog levels were off the charts, A uthorities warn people there to stay inside, Last year nearly 700 flights were canceled at Beijing airports because of haze and smog, Officials in China say that the air quality in the capital has gotten better since Beijing hosted the 2008 Olympics, but residents say the pollution levels have gotten worse.", "pos": "The peace Treaty of Limerick signed on 3 October 1691 offered favourable terms to Jacobites willing to stay in Ireland and give an oath of loyalty to William III. Peace was concluded on these terms between Sarsfield and Ginkell, giving toleration to Catholicism and full legal rights to Catholics that swore an oath of loyalty to William III and Mary II. The Protestant-dominated Irish Parliament refused to ratify the articles of the Treaty in 1697, and from 1695 on, updated the penal laws, which discriminated harshly against Catholics. Catholics saw this as a severe breach of faith. A popular contemporary Irish saying was, cuimhnigi Luimneach agus feall na Sassanaigh . The Papacy was an enemy of Louis of France and therefore did not support James in 1691, but the new Pope Pope Innocent XII changed its policy to support for France, and therefore James, from 1693. This factor hardened Protestant attitudes towards Catholics and Jacobitism in Ireland. Part of the treaty agreed to Sarsfield's demand that the Jacobite army could leave Ireland as a body and go to France. Ships were even provided for this purpose. This event was popularly known in Ireland as the \"Flight of the Wild Geese\". Around 14,000 men with around 10,000 women and children left Ireland with Patrick Sarsfield in 1691. Initially, they formed the army in exile of James II, though operating as part of the French army. After James' death, the remnants of this force merged into the French Irish Brigade, which had been set up in 1689 from 6,000 Irish recruits sent by the Irish Jacobites in return for French military aid.", "neg": "The smallest front of the war was in Catalonia. In 1689 the Duke of Noailles had led French forces there aimed at bringing further pressure to bear on the Spanish by re-igniting a peasant rising against Charles II, which initially broke out in 1687. Exploiting the situation, Noailles captured Camprodon on 22 May, but a larger Spanish army under the Duke of Villahermosa forced him to withdraw back to Roussillon in August. The Catalan campaign settled down in 1690, but a new front in Piedmont-Savoy proved more eventful. A ferment of religious animosities and Savoyard hatred of the French produced a theatre characterised by massacres and atrocities: constant guerrilla attacks by the armed populace were met by draconian reprisals. In 1690 Saint-Ruth took most of the Victor Amadeus II's exposed Duchy of Savoy, routing the Savoyard army in the process until only the great fortress of Montmelian remained in ducal hands; while to the south in Piedmont, Nicolas Catinat led 12,000 men and soundly defeated Victor Amadeus at the Battle of Staffarda on 18 August. Catinat immediately took Saluzzo, followed by Savigliano, Fossano, and Susa, but lacking sufficient troops, and with sickness rife within his army, Catinat was obliged to withdraw back across the Alps for the winter.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}186{"query": "Transcription factors belonging to the nuclear factor of activated T cells (NFAT) family regulate the expression of cytokine genes and other inducible genes during the immune response. The functions of NFAT proteins are directly controlled by the calcium- and calmodulin-dependent phosphatase calcineurin. Here we show that the binding of calcineurin to NFAT is substantially increased when calcineurin is activated with calmodulin and calcium. FK506.FKBP12 drug-immunophilin complexes inhibited the interaction of NFAT with activated calcineurin much more effectively than they inhibited the interaction with inactive calcineurin, suggesting that part of the interaction with activated calcineurin involved the enzyme active site. We have previously shown that NFAT is targeted to inactive calcineurin at a region distinct from the calcineurin active site (Aramburu, J., Garcia-Cozar, F. J., Raghavan, A., Okamura, H., Rao, A., and Hogan, P. G. (1998) Mol. Cell 1, 627-637); this region is also involved in NFAT binding to activated calcineurin, since binding is inhibited by an NFAT peptide spanning the calcineurin docking site on NFAT. The interacting surfaces are located on the catalytic domain of the calcineurin A chain and on an 86-amino acid fragment of the NFAT regulatory domain. NFAT binding to the calcineurin catalytic domain was inhibited by the calcineurin autoinhibitory domain and the RII substrate peptide, which bind in the calcineurin active site, as well as by the NFAT docking site peptide, which binds to a region of calcineurin distinct from the active site. We propose that, in resting cells, NFAT is targeted to a region of the calcineurin catalytic domain that does not overlap the calcineurin active site. Upon cell activation, displacement of the autoinhibitory domain by calmodulin binding allows NFAT to bind additionally to the calcineurin active site, thus positioning NFAT for immediate dephosphorylation at functional phosphoserine residues.", "pos": "Calcium activated gene transcription through Nuclear Factor of Activated T-cells, (NFAT) proteins, is emerging as a ubiquitous mechanism for the control of important physiological processes. Of the five mammalian NFAT isoforms, transcriptional activities of NFATs 1-4 are stimulated by a calcium driven association between the ubiquitous phosphatase calcineurin and the calcium-sensing protein calmodulin. Published in vitro evidence has suggested that other members of the calmodulin super-family, in particular the neuronal calcium sensor (NCS) proteins, can similarly modulate calcineurin activity. In this study we have assessed the ability of NCS proteins to interact directly with calcineurin in vitro and report a specific if weak association between various NCS proteins and the phosphatase. In an extension to these analyses we have also examined the effects of over-expression of NCS-1 or NCS-1 mutants on calcineurin signalling in HeLa cells in experiments examining the dephosphorylation of an NFAT-GFP reporter construct as a readout of calcineurin activity. Results from these experiments indicate that NCS-1 was not able to detectably modulate calcineurin/NFAT signalling in a live mammalian cell system, findings that are consistent with the idea that calmodulin and not NCS-1 or other NCS family proteins is the physiologically relevant modulator of calcineurin activity.", "neg": "Differentiation of cancer stem cells (CSCs) into cancer cells causes increased sensitivity to chemotherapeutic agents. Although inhibition of mammalian target of rapamycin (mTOR) leads to CSC survival, the effect of branched chain amino acids (BCAAs), an mTOR complex 1 (mTORC1) activator remains unknown. In this study, we examined the effects of BCAA on hepatocellular carcinoma (HCC) cells expressing a hepatic CSC marker, EpCAM. We examined the effects of BCAA and/or 5-fluorouracil (FU) on expression of EpCAM and other CSC-related markers, as well as cell proliferation in HCC cells and in a xenograft mouse model. We also characterized CSC-related and mTOR signal-related molecule expression and tumorigenicity in HCC cells with knockdown of Rictor or Raptor, or overexpression of constitutively active rheb (caRheb). mTOR signal-related molecule expression was also examined in BCAA-treated HCC cells. In-vitro BCAA reduced the frequency of EpCAM-positive cells and improved sensitivity to the anti-proliferative effect of 5-FU. Combined 5-FU and BCAA provided better antitumor efficacy than 5-FU alone in the xenograft model. Stimulation with high doses of BCAA activated mTORC1. Knockdown and overexpression experiments revealed that inhibition of mTOR complex 2 (mTORC2) or activation of mTORC1 led to decreased EpCAM expression and little or no tumorigenicity. BCAA may enhance the sensitivity to chemotherapy by reducing the population of cscs via the mTOR pathway. This result suggests the utility of BCAA in liver cancer therapy.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}187{"query": "In 1953, 10-year-old Larry Flynt is selling moonshine in Kentucky. Twenty years later, Flynt (Woody Harrelson) and his younger brother, Jimmy (Brett Harrelson) run the Hustler Go-Go club in Cincinnati. With profits down, Flynt decides to publish a newsletter for the club, the first Hustler magazine, with nude pictures of women working at the club. The newsletter soon becomes a full-fledged magazine, but sales are weak. In 1975, after Hustler publishes nude pictures of former first lady Jackie Kennedy Onassis, sales take off.Flynt becomes smitten with Althea Leasure (Courtney Love), a stripper who works at one of his clubs. With Althea and Jimmy's help, Flynt makes a fortune from sales of Hustler. With his success comes enemies - as he finds himself a hated figure of anti-pornography activists. He argues with the activists, saying that \"murder is illegal, but if you take a picture of it you may get your name in a magazine or maybe win a Pulitzer Prize\". \"However\", he continues, \"sex is legal, but if you take a picture of that act, you can go to jail\". He becomes involved in several prominent court cases, and befriends a young lawyer, Alan Isaacman (Edward Norton). In 1975, Flynt loses a smut-peddling court decision in Cincinnati but is released from jail soon afterwards on a technicality. Ruth Carter Stapleton (Hanover), a Christian activist and sister of President Jimmy Carter, seeks out Flynt and urges him to give his life to Jesus. Flynt seems moved and starts letting his newfound religion influence everything in his life, including Hustler content.In 1978, during another trial in Georgia, Flynt and Isaacman are both shot by a man with a rifle while they walk outside a courthouse. Isaacman recovers, but Flynt is paralyzed from the waist down and uses a wheelchair for the rest of his life. Wishing he was dead, Flynt renounces God. Because of the emotional and physical pain, he moves to Beverly Hills, California and spirals down into depression and drug use. During this time, Althea also becomes addicted to painkillers and morphine.In 1983, Flynt undergoes back surgery to deaden several nerves, and as a result, feels rejuvenated. He returns to an active role with the publication, which, in his absence, had been run by Althea and Jimmy. That same year, Flynt is soon in court again for leaking videos relating to the John DeLorean entrapment case, and during his courtroom antics, he fires Isaacman, then throws an orange at the judge. He later wears an American flag as an adult diaper along with an army helmet, and wears T-shirts with provocative messages such as \"I Wish I Was Black\" and \"Fuck This Court.\" After spitting water at the judge Flynt is sent to a psychiatric ward, where he sinks into depression again. He is diagnosed with having bipolar disorder and forced to take treatment.During this time, Flynt publishes a satirical parody ad in which Christian fundamentalist preacher Jerry Falwell tells of a sexual encounter with his mother. Falwell sues for libel and emotional distress. Flynt countersues for copyright infringement, because Falwell copied his ad. The case goes to trial in December 1984, but the decision is mixed, as Flynt is found guilty of inflicting emotional distress but not libel.By that time, Althea has contracted HIV, which proceeds to AIDS. Some time later in 1987, Flynt finds her dead in the bathtub, having drowned. Flynt presses Isaacman to appeal the Falwell decision to the Supreme Court of the United States. Isaacman refuses, saying Flynt's courtroom antics humiliated him. Flynt pleads with him, saying that he \"wants to be remembered for something meaningful\". Isaacman agrees and argues the \"emotional distress\" decision in front of the Supreme Court, in the case Hustler Magazine v. Falwell in 1988. With Flynt in the courtroom, the court overturns the original verdict in a unanimous decision. After the trial, Flynt is alone in his bedroom watching old videotapes of a healthy Althea.", "pos": "Newspaper columnist John Klein (Richard Gere) and his wife Mary (Debra Messing) are involved in an accident when Mary swerves to avoid a black, flying figure. John survives the crash unscathed, but Mary is hospitalized. After Mary dies of an unrelated brain tumor, John discovers mysterious drawings of the creature that she had created prior to the night of the accident. Two years later, John becomes lost in West Virginia and inexplicably finds himself in Point Pleasant, hundreds of miles off his route. Driving in the middle of the night, his car breaks down; and he walks to a nearby house to get help. The owner, Gordon Smallwood (Will Patton), reacts violently to John's appearance and holds him at gunpoint. Local police officer Connie Mills (Laura Linney) defuses the situation while Gordon explains that this is the third consecutive night John has knocked on his door asking to use a phone, much to John's confusion. John stays at a local motel and considers how he ended up so far from his original destination. Officer Mills mentions to John that many strange things have been occurring in the past few weeks and that people report seeing a large winged creature like a giant moth with red eyes. She also tells John about a strange dream she had, in which the words \"Wake up, Number 37\" were spoken to her. While conversing with Gordon one day, it is revealed to John that he had heard voices from his sink telling him that, in Denver, \"99 will die\". While discussing the day's events at a local diner, John notices that the news is showing a story on an airplane crash in Denver that killed all 99 passengers aboard. The next night, Gordon frantically explains that he had met the voices in his head, a being named Indrid Cold Later that night, Gordon calls John and says that he is standing with a character named Indrid Cold. While John keeps Cold on the line, Officer Mills checks on Gordon. Cold answers John's questions, convincing him that he is a supernatural being. This episode starts a string of supernatural calls to John's motel room. One tells him that there will be a great tragedy on the Ohio River. Later, John receives a call from Gordon and rushes to his home to check on him. He finds Gordon outside, dead from exposure. John becomes obsessed with the being, dubbed Mothman. He meets an expert on the subject, Alexander Leek (Alan Bates), who explains its nature and discourages John from becoming further involved. However, when John learns the governor (Murphy Dunne) plans to tour a chemical plant located on the Ohio River the following day, he becomes convinced the tragedy will occur there. Officer Mills and the governor ignore his warnings, and nothing happens during the tour. Soon afterwards, John receives a mysterious message that instructs him to await a call from his deceased wife Mary back in Georgetown, and he returns home. On Christmas Eve, Officer Mills calls and convinces him to ignore the phone call from \"Mary\", return to Point Pleasant, and join her. Though anguished, John agrees. As John reaches the Silver Bridge, a malfunctioning traffic light causes traffic congestion. As John walks onto the bridge to investigate, the bolts and supports of the bridge strain. The bridge comes apart, and John realizes that the prophesied tragedy on the Ohio River was about the bridge. As the bridge collapses, Officer Mills's car falls into the water. John jumps in after her and pulls her from the river and up to safety. As the two sit on the back of an ambulance, they see that 36 people have been killed, making Connie the \"number 37\" from her dream. The epilogue displays a series of graphics that state the cause of the bridge collapse was never fully determined. It also states that, although the Mothman has been sighted in other parts of the world, it was never seen again in Point Pleasant.", "neg": "Webb Garwood (Van Heflin), a disgruntled cop, is called to investigate a voyeur by Susan Gilvray (Evelyn Keyes). Her husband works nights as an overnight radio personality. Webb falls in love with the young and attractive married woman. Obsessed, he woos her despite her initial reluctance and the two begin an adulterous affair. Webb finds out about an insurance policy on the husband's life. He dreams up a scheme in which a phantom \"prowler\" would be a good scapegoat if Susan's husband should happen to die mysteriously. After becoming a prowler himself, Webb \"investigates\" and then commits the murder, making it look like a tragic accident with he and the husband shooting at each other as each suspected the other of being the prowler. Webb's ruse fools a coroner's jury, thanks in part to both Susan and Webb testifying that they didn't know each other prior to her husband's death. Susan initially suspects Webb of foul play, but becomes convinced of his innocence and subsequently marries him. Shortly after the wedding, Susan informs Webb that she has been pregnant for four months. This is problematic because the date of the child's conception would prove the two had lied in their testimony to cover up their previous relationship, and would thus suggest that Webb's killing of Susan's husband had not been an accident. The two run away to a ghost town named Calico to have the baby without anyone back home knowing. Susan goes into premature labor and Webb finds a doctor, Dr. William James (Wheaton Chambers). Susan realizes that Webb intends to kill Dr. James to preserve their secret, so she warns the doctor who then escapes with the newborn. Susan tells Webb that she knows what he had planned to do and that she now realizes that he intentionally murdered her husband. Realizing the doctor will send the police after him, Webb drives away, leaving his wife in Calico alone. On the way out of town, he find the road blocked by his former partner on the police force who was coming to pay a visit. While attempting to get around his friend's car, Webb sees several police cars coming so he heads for the hills on foot. He refuses to stop and a sheriff's deputy shoots him dead.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}188{"query": "A&W Cream Soda is a cream soda carbonated soft drink introduced by A&W Root Beer in 1986.", "pos": "The original construction permit for the station was granted on July 1, 1983, and the WLKZ call letters were assigned on October 11; it took to the air on February 1, 1985, and a license to cover was granted on June 4, 1985.", "neg": "The 1988 Dungeons & Dragons role-playing game module Ruins of Adventure was produced using the same adventure scenario as Pool of Radiance, using the same plot, background, setting, and many of the same characters as the computer game.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}189{"query": "The fourteenth week of the season featured a game between 5-7 teams as the Washington Redskins visited Soldier Field. In 48 games, the Redskins led the series 24-23-1 and had won the last five meetings. The Chicago offense took on a Washington defense that excelled against passers, being ranked tenth in the category; Dashon Goldson led all defensive backs in tackles with 95, while Bashaud Breeland led the team in passes defended with 13. The Redskins defensive rush, which had 20 sacks in 2015, was led by Ryan Kerrigan, who has 6.5. Despite such performances, the Redskins rush defense was ranked 29th in yards per carry with 4.64 and 25th in average rushing yards at 124.2. Jeff Joniak writes that the Bears could exploit this with the three-man rushing attack of Matt Forte, Jeremy Langford, and Ka'Deem Carey. On defense, the Bears faced a Kirk Cousins-led offense that focuses on quick passes; Cousins completed a league-high 68.6 percent of his passes, with 7.1 yards per pass. One of Cousins' main targets was tight end Jordan Reed, who scored six touchdowns and led the Redskins in yards after the catch. Rankings-wise, the pass attack was ranked 17th in the league in passing yards per game and 16th for yards per play. Joniak states that the Bears had to force turnovers, and an area was on third down, as five of Cousins' interceptions had been on third down. The Bears won the coin toss and elected to defer. Washington recorded a 15-play, 80-yard drive en route to scoring on Alfred Morris' one-yard touchdown run. After the Bears punted, the Redskins scored again with Cousins' fake read option leading to a three-yard touchdown run in the second quarter. Chicago's woes continued when the offense began the next drive on their own seven-yard line, and despite reaching the Washington 49, Jay Cutler was strip-sacked by Trent Murphy, who recovered the fumble. The Redskins failed to capitalize on the turnover and punted; the following two drives also ended with punts. With 52 seconds left in the first half, the Bears took over at their own 42, and managed to score with 18 seconds left when Cutler threw a 20-yard touchdown pass to Alshon Jeffery. Cousins kneeled once to end the half. After the Bears punted on the first drive of the second half, Cousins threw a five-yard touchdown pass to Reed. The Bears responded with Cutler's nine-yard touchdown pass to Zach Miller, who managed to escape DeAngelo Hall and made contact with Goldson as he reached the endzone. The score was the Bears' first third quarter touchdown of 2015. Afterwards, Cousins' pass for Pierre Garcon was intercepted by Kyle Fuller, and the Bears took advantage with Forte's seven-yard touchdown run to tie the score. Dustin Hopkins gave the Redskins the 24-21 lead on the first drive of the final quarter with a 47-yard field goal. Five drives later, the Bears attempted a 50-yard field goal with 1:40 left in the game. However, Robbie Gould's kick sailed wide left, and the Redskins ran the ball three times to end the game.", "pos": "The Cardinals dueled with the Minnesota Vikings for the #3 seed in the NFC playoffs. Things looked bleak for the Cardinals from the beginning. The Vikings began their first quarter attack with an 82-yard punt return for a TD by Bernard Berrian. Two turnovers for the Cardinals, Kurt Warner interception and an Anquan Boldin fumble, would lead to two touchdown passes from Tarvaris Jackson, a 41-yard pass to Berrian and a 19-yard pass to Sidney Rice. The Vikings took a 28-0 lead at halftime after an 11-yard TD pass from Jackson to Chester Taylor. The Cardinals would rally to cut the lead in half with a Jerheme Urban 50-yard TD catch and a field goal blocked by Dominique Rodgers-Cromartie and recovered by Roderick Hood, who returned it 68 yards for a touchdown. The Vikings would pull away at the end of the third quarter when Jackson threw a 59-yard TD pass to Bobby Wade. Kurt Warner was benched on the Cardinals last drive in the fourth quarter via a coaching decision.", "neg": "The 2016 Conference on Retroviruses and Opportunistic Infections (CROI) highlighted hot spots in HIV infection. Men who have sex with men (MSM), transgender populations, people who inject drugs, fisherfolk, migrants, adolescents, and older adults are heavily impacted in a number of regions. Stigma contributes to risk behaviors and HIV acquisition across populations. HIV testing is a crucial first step in the HIV care continuum, and several large community-based surveys are underway in Africa to increase HIV testing, linkage to care, and uptake of antiretroviral treatment. Advances in preexposure prophylaxis (PrEP) featured prominently at CROI 2016. Two large efficacy trials of a vaginal ring containing the investigational drug dapivirine demonstrated efficacy and safety in preventing HIV infections in women in Africa. Data on the safety of long-acting injectable PrEP and several investigational PrEP drugs and formulations were also presented. Knowledge and use of PrEP among MSM in the United States appears to be increasing, and high uptake was seen among black MSM when provided as part of a culturally tailored support program. The use of broadly neutralizing antibodies for HIV prevention is a novel and promising approach to be evaluated in efficacy trials.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}190{"query": "Brouwerij Nacional Balashi was founded in 1996 by one of Aruba's largest companies, MetaCorp.", "pos": "SinnerSchrader was founded in 1996 by Oliver Sinner and Matthias Schrader in Hamburg, Germany by combining a marketing business and a software company that both operated under the sinner + schrader name.", "neg": "Sharman Douglas died of bone cancer at New York Hospital in 1996.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}191{"query": "The U.S. Census for 2010 reported 332,199 households in Indianapolis, with an average household size of 2.42 and an average family size of 3.08. Of the total households, 59.3% were family households, with 28.2% of these including the familys own children under the age of 18; 36.5% were husband-wife families; 17.2% had a female householder (with no husband present) and 5.6% had a male householder (with no wife present). The remaining 40.7% were non-family households. , 32% of the non-family households included individuals living alone, 8.3% of these households included individuals age 65 years of age or older.", "pos": "There were 22,000 households of which 37.1% had children under the age of 18 living with them, 48.3% were Marriage living together, 12.7% had a female householder with no husband present, 5.1% had a male householder with no wife present, and 33.9% were non-families. 26.7% of all households were made up of individuals and 7.5% had someone living alone who was 65 years of age or older. The average household size was 2.70 and the average family size was 3.24.", "neg": "As of the census of 2000, there were 35,100 people, 12,759 households, and 9,071 families residing in the county. The population density was 59 people per square mile (23/km). There were 15,035 housing units at an average density of 25 per square mile (10/km). The racial makeup of the county was 85.8% Race (United States Census), 3.9% Race (United States Census) or Race (United States Census), 1.8% Race (United States Census), 1.0% Race (United States Census), 0.1% Race (United States Census), 5.0% from Race (United States Census), and 2.4% from two or more races. 8.9% of the population were Race (United States Census) or Race (United States Census) of any race. 14.9% were of German people, 12.6% English people, 11.7% Irish people, 8.8% Italian people and 7.3% United States ancestry according to Census 2000. 93.1% spoke English language and 5.1% Spanish language as their first language.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}192{"query": "HD 90089 is a suspected variable star in the constellation Camelopardalis.", "pos": "HD 79447, also known as i Carinae (i Car) is a star in the constellation Carina.", "neg": "Johann Bayer used the Greek letters Alpha to Eta to label the most prominent eight stars in the constellation, designating two stars as Delta (named Delta1 and Delta2). John Flamsteed numbered fourteen stars, discerning a third star he named Delta3; his star 12 Canis Minoris was not found subsequently. In Bayers 1603 work Uranometria, Procyon is located on the dogs belly, and Gomeisa on its neck. Gamma Canis Minoris, Epsilon Canis Minoris and Eta Canis Minoris lie nearby, marking the dogs neck, crown and chest respectively. Although it has an apparent magnitude of 4.34, Gamma Canis Minoris is an orange stellar classification giant star of spectral class K3-III C, which lies away. Its colour is obvious when seen through binoculars. It is a multiple system, consisting of the spectroscopic binary Gamma A and three optical companions, Gamma B, magnitude 13; Gamma C, magnitude 12; and Gamma D, magnitude 10. The two components of Gamma A orbit each other every 389.2 days, with an eccentric orbit that takes their separation between 2.3 and 1.4 astronomical units (AU). Epsilon Canis Minoris is a yellow bright giant of spectral class G6.5IIb of magnitude of 4.99. It lies from Earth, with 13 times the diameter and 750 times the luminosity of the Sun. Eta Canis Minoris is a giant of spectral class F0III of magnitude 5.24, which has a yellowish hue when viewed through binoculars as well as a faint companion of magnitude 11.1. Located 4 arcseconds from the primary, the companion star is actually around 440 AU from the main star and takes around 5000 years to orbit it.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}193{"query": "Alpha-synuclein forms the major component of Lewy bodies and Lewy neurites, the defining neuropathological characteristics of Parkinson's disease and dementia with Lewy bodies. Here we show that alpha-synuclein is also the major component of the filamentous inclusions of multiple system atrophy which comprises several neurodegenerative diseases with a shared filamentous pathology in nerve cells and glial cells. These findings provide an unexpected link between multiple system atrophy and Lewy body disorders and establish that alpha-synucleinopathies constitute a major class of human neurodegenerative disorder.", "pos": "Lewy bodies and coarse Lewy neurites are the pathological hallmarks of degenerating neurons in the brains of patients suffering from Parkinson's disease (PD). Recently, the presynaptic protein alpha-synuclein was shown to be a major component of Lewy bodies and Lewy neurites. This study demonstrates for the first time that extensive and thin alpha-synuclein-immunoreactive inclusions are present in the axonal processes of neurons.", "neg": "A mutation in the ubiquilin 2 gene (UBQLN2) was recently identified as a cause of X-linked amyotrophic lateral sclerosis (ALS)/frontotemporal dementia (FTD) and a major component of the inclusion bodies commonly found with a wide variety of ALS. ALS-linked mutations in UBQLN2 are clustered in a unique proline-X-X repeat region, reportedly leading to impairment of the ubiquitin proteasome system. However, the molecular properties of mutant UBQLN2 remain unclear. To gain insight into the pathogenesis of UBQLN2-linked ALS/FTD, we examined the biochemical and cellular characteristics of mutant UBQLN2 in vitro. UBQLN2 localized in Rab11-positive endosomal vesicles formed by the ALS-linked molecule optineurin (OPTN). These vesicles were ubiquitin- and p62-immunopositive and also co-localized with an initiator of the autophagic process, ULK1, after amino acid starvation. An ALS-linked mutation (E478G) in OPTN abolished vesicle formation. ALS-linked mutations in UBQLN2 additively enhanced UBQLN2 aggregation and formation of inclusion bodies, resulting in mislocation from OPTN vesicles. UBQLN2 was found to be a potent regulator of the levels of the FTD-linked secretory factor progranulin, possibly via the endosomal system, and ALS-linked mutations disturbed these functional consequences. This study demonstrates that ALS-linked mutations in both OPTN and UBQLN2 interfere with the constitution of specific endosomal vesicles, suggesting that the vesicles are involved in protein homeostasis and that these proteins function in common pathological processes. These data suggest a novel disease spectrum and provide new pathological insights into OPTN and UBQLN2, enhancing our understanding of the molecular basis of ALS/FTD.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}194{"query": "To evaluate the role of idarucizumab, a humanized monoclonal antibody fragment, as a specific reversal agent for the anticoagulant activity of dabigatran and to review the pharmacology, pharmacokinetic properties, efficacy, and safety of this agent. A literature search was conducted consisting of a PubMed database using the MeSH term idarucizumab and the key word dabigatran antidote. Studies evaluating the pharmacology, pharmacokinetics, safety, and efficacy of idarucizumab for the reversal of the anticoagulant activity of dabigatran were included. Idarucizumab represents a novel treatment option as it is the only humanized, monoclonal antibody fragment that specifically binds to dabigatran. Studies evaluating reversal of dabigatran-induced anticoagulation have demonstrated immediate, complete, and sustained effects with idarucizumab. Idarucizumab did not overcorrect thrombin generation. Additionally, evaluations have shown that dabigatran can be safely reinitiated 24 hours after the administration of idarucizumab. The United States Food and Drug Administration granted priority review for the biologic license application and accelerated approval for idarucizumab. Idarucizumab represents an encouraging development in the reversal of dabigatran. Its novel mechanism of action, pharmacokinetics, tolerability, and lack of thrombotic events contribute positively to its use in patients who experience bleeding or for those who require emergent surgery or procedures.", "pos": "Urgent surgery or life-threatening bleeding requires prompt reversal of the anticoagulant effects of dabigatran. This study assessed the ability of three- and four-factor prothrombin complex concentrate (PCC) and idarucizumab (specific antidote for dabigatran) to reverse the anticoagulant effects of dabigatran in a porcine model of trauma. Twelve animals were given dabigatran etexilate (DE) orally and dabigatran intravenously, before infliction of trauma. Six animals received tranexamic acid plus fibrinogen concentrate 12 minutes post-injury. Six PCCs (each 30 and 60 U/kg) and idarucizumab (30 and 60 mg/kg) were added to blood samples ex vivo. Coagulation was assessed by several coagulation assays. All coagulation parameters were altered after dabigatran infusion (plasma level: 442 138 ng/ml). Both three- and four-factor PCCs mostly or completely reversed the effects of dabigatran on thromboelastometry variables and PT but not on aPTT. Idarucizumab neutralised plasma concentrations of dabigatran, and reversed the effects of the drug on coagulation variables. Thrombin generation showed dose-dependent over-correction following the addition of PCC, implying that elevated levels of thrombin are required to overcome dabigatran-induced coagulopathy. In contrast, treatment with idarucizumab returned thrombin generation to baseline levels. Following trauma, therapy with tranexamic acid plus fibrinogen improved correction of coagulation parameters by PCC, and thromboelastometry parameters by idarucizumab. All investigated PCCs improved dabigatran- and trauma-induced coagulopathy to a similar degree. In conclusion, this study shows that three- and four-factor PCCs are similarly effective for dabigatran reversal. Idarucizumab also reversed the effects of dabigatran and, unlike PCCs, was not associated with over-correction of thrombin generation.", "neg": "Dasatinib is a dual Abl/Src tyrosine kinase inhibitor (TKI) designed as a prototypic short-acting BCR-ABL-targeted TKI that inhibits BCR-ABL with greater potency compared with imatinib, nilotinib, bosutinib, and ponatinib and has been shown to have potential immunomodulatory effects. Dasatinib is approved for the treatment of all phases of chronic myeloid leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia resistant or intolerant to prior imatinib treatment and first-line treatment for CML in chronic phase. In this article, the development of dasatinib as a treatment for patients with CML is reviewed. This is a review of the relevant literature regarding dasatinib development in CML (2003-2013). Dasatinib demonstrates efficacy against most BCR-ABL mutations arising during imatinib therapy and is effective in treating patients with imatinib resistance due to other mechanisms. Randomized trial data show that first-line dasatinib provides superior responses compared with imatinib and enables patients to achieve early, deep responses correlated with improved longer-term outcomes. Dasatinib has a generally acceptable safety profile, with most adverse events (AEs) proving manageable and reversible. Cytopenias are commonly observed with dasatinib, and some nonhematologic AEs including pleural effusion have been consistently reported. Dasatinib is an effective treatment option for patients with CML.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}195{"query": "The smallest front of the war was in Catalonia. In 1689 the Duke of Noailles had led French forces there aimed at bringing further pressure to bear on the Spanish by re-igniting a peasant rising against Charles II, which initially broke out in 1687. Exploiting the situation, Noailles captured Camprodon on 22 May, but a larger Spanish army under the Duke of Villahermosa forced him to withdraw back to Roussillon in August. The Catalan campaign settled down in 1690, but a new front in Piedmont-Savoy proved more eventful. A ferment of religious animosities and Savoyard hatred of the French produced a theatre characterised by massacres and atrocities: constant guerrilla attacks by the armed populace were met by draconian reprisals. In 1690 Saint-Ruth took most of the Victor Amadeus II's exposed Duchy of Savoy, routing the Savoyard army in the process until only the great fortress of Montmelian remained in ducal hands; while to the south in Piedmont, Nicolas Catinat led 12,000 men and soundly defeated Victor Amadeus at the Battle of Staffarda on 18 August. Catinat immediately took Saluzzo, followed by Savigliano, Fossano, and Susa, but lacking sufficient troops, and with sickness rife within his army, Catinat was obliged to withdraw back across the Alps for the winter.", "pos": "The revolt of the pitauds was a French peasants' revolt in the mid-16th century. The revolt was sparked by the 1541 decree of Chatellerault, which extended a salt tax to Angoumois and Saintonge . It was made compulsory to purchase salt from the salt loft . \"Gabelle\" officers took charge of punishing the unlawful trading of salt. But these were salt pan areas where the salt was freely traded. Salt smuggling spread rapidly, especially after the Marennes and La Rochelle revolts in 1542, and the repression by the salt riders is out of the population acceptance. In 1548, riots break out in Angoumois and Saintonge demanding the release of the smugglers . The de Pitauds revolt grew to 20,000 members, led by a lord and joined by priests. Castles were plundered and salt-tax collectors killed. The revolt spread to Bordeaux where 20 salt tax collectors were killed, including the lieutenant governor, on August 21, 1548. King Henry II blockaded Bordeaux and launched his repression. Bordeaux lost its privileges. It was disarmed, paid a fine, saw its parliament suspended, and 1,401 people were sentenced to death. The repression spread to the countryside where the leaders were hanged: neither priests nor gentlemen were spared. The salt-tax was finally abolished in these provinces in June 1549, the provinces became redeemed countries, and the King issued a general amnesty.", "neg": "The French Revolution broke out in 1789. At the time France was in a crisis. The government was badly run and people's lives were miserable. King Louis XIV tried to control the national parliament and raise more taxes. But his effort failed. He ordered his troops to Versailles. The people thought that Louis intended to put down the Revolution by force. On July 14, 1789, they stormed and took the Bastille, where political prisoners were kept. Ever since that day, July 14 has been the French National Day. Louis tried to flee the country in 1792, to get support from Austria and Prussia. However, he was caught and put in prison. In September 1792, the monarchy was abolished _ . In the same year, Louis was executed. A few months later his wife, Marie also had her head cut off. The Revolution of France had frightened the other kings of Europe. Armies from Austria and Prussia began to march against France. The French raised republican armies to defend the nation. The Revolution went through a period of terror. Thousands of people lost their lives. In the end, power passed to Napoleon Bonaparte.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}196{"query": "An 11-day embryonic Swiss Webster/NIH mouse cDNA library was screened with a partial murine selenoprotein P cDNA probe and a murine selenoprotein-P-type cDNA clone of 2075 bp length was obtained. The clone contained a 5'-leader sequence of 132 bp length, the selenoprotein P coding frame, and 803 base pairs in the 3' untranslated region. Alignment and RNA folding studies revealed the presence of two well conserved selenocysteine inserting motifs in the 3' flanking region. The deduced polypeptide sequence comprises 380 residues including ten selenocysteines. Identical amino acid residues in homologous positions are 86%, 71%, and 64% when compared to the previously reported selenoprotein P sequences of rat, man, and cattle, respectively. The comparatively low similarity between the selenoprotein P sequences reported so far leaves open the question whether they belong to the same molecular clade.", "pos": "When cDNA containing proteins enriched in the bovine cerebellar cortex were cloned, a clone which seemed to encode a selenoprotein P-like protein was isolated. The coding nucleotide sequence of its cDNA insert displayed high homology to rat and human selenoprotein P cDNA but contained 12 rather than 10 TGAs (12 rather than 10 selenocysteines in deduced amino acids), a tandem repeat of one CACTCC (His-Ser) and seven CATCCCs (His-Pro), and a 3' untranslated region approximately 890 bases shorter than that of rat liver selenoprotein P. RT-PCR using a set of primers flanking to the repeat displayed the existence of mRNA without the repeat. The tandem repeat and its adjacent region consisted of a similar motif of CAC/TCC/AC/T. Thus, these proteins included a (His-Pro) rich domain with a slightly negative free energy change irrespective of having the tandem repeat or not. Such His-Pro repeats reportedly exist in the segmentation gene paired or homeobox protein Om(1D) of Drosophila. Moreover, both this selenoprotein P-like protein mRNA and selenoprotein P mRNA were expressed in all the areas of the brain but most prominently in the cerebellar cortex, hippocampus, and olfactory bulb. These findings suggest the possibility that these selenoproteins are major selenium carriers in the brain and play a role in the morphological response of nerve or glial cells.", "neg": "We have determined sequences of PCR-amplified B1 elements from hamster and rat (Myomorpha), chipmunk (Sciuromorpha), and guinea pig (Caviomorpha). Between three and six B1 subfamilies were found in these species. In the phylogenetic analysis B1 sequences of hamster, mouse, and rat clustered separately from those of chipmunk and those of guinea pig. This is consistent with an independent evolution of B1 elements in separate rodent lineages. We exclude the possibility of convergent mutations to explain certain diagnostic characters within the modern B1 quasi-dimers and view these elements as mosaic structures assembling preexisting mutations. Furthermore, the presence of Alu-like structural motifs supports the hypothesis of the monophyletic origin of Alu and B1 repeats, i.e., from a common 7SL RNA-derived retroposing monomeric element.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}197{"query": "Televisions were among the most talked about items at the 2013 International Consumer Electronics Show last week in Las Vegas, Nevada. Some employed the most advanced technology ever. Some of the TVs used a new technology called Organic Light Emitting Diodes, or OLED. They were thinner, lighter, offered better color1 and were brighter than traditional LEDs. Smart TVs this year were smarter. Many offered technology that let users have a more personalized experience. One such TV from the electronics company TCL uses sensors and voice recognition to determine who is watching. It then offers programming based on the specific user. Another TV from Panasonic offers a similar personalized user experience. In addition to television technology, size also played a major part in CES 2013. Televisions varied in size from big to bigger, with at least two companies -- Samsung and HiSense -- exhibiting TVs measuring 110 inches. The yearly Consumer Electronics Show is the biggest technology trade show in North America and one of the biggest in the world. Gary Shapiro is president and CEO of the Consumer Electronics Association, the group that organizes CES. He gave one of the keynote speeches on opening day. \"Now you know that CES is more than a trade show. It's a gathering of the brightest minds and the top leaders from many industries and those seeking a glimpse into the future.\" That glimpse into the future included a look at digital health and fitness devices, which were also big at CES 2013. There were devices that track your activity and others that measure blood pressure, heart rate and weight. There was even a fork that tells you when you are eating too fast. Cars, smart-phones, tablet computers and PCs also made news. And a 27-inch table computer drew quite a bit of attention. CEA President Gary Shapiro says there was much to see but not nearly enough time to see it all. \"You cannot see the show in the four days that you have. We have over 3200 different industries showing over 20,000 new products. It's ly incredible.\"", "pos": "According to a survey released by the Nielson Company on Thursday, China has become a global tourist attraction after the Beijing Olympics. The survey said the Olympics not only built up China's image but also served as an advertisement for China's tourism. The online survey was conducted on consumers in 16 countries and regions before Games' opening ceremony and after the closing. About 80 percent of the respondents had not been to China before the events and 50 percent of them expressed hopes of visiting China after the Games. According to the survey, 70 percent of the respondents felt Beijing was more modern and scientific than what they had thought. The most interested respondents were from Singapore, India, Mexico, South Africa and the Republic of Korea, as well as China's Hong Kong and Taiwan. Pan Wen, in charge of Chinese tourism research of the Nielson Company, said the World Tourism Organization predicted that China would become the largest tourist attraction in the world with 137 million foreign tourists every year. \"This figure would be realized earlier with the aid of the Beijing Olympics,\" Pan said.", "neg": "School leaders from around the country gathered at the White House on November 19 for\"Connected to the Future,\" a conference about digital technology in education.Connected is the Obama Government's five-year plan to support the growth of digital learning in schools.This growth includes equipping America's schools with high-speed broadband Internet . At the conference,President Barack Obama said the U.S.Department of Education is taking steps to help educators and school districts as they change to digital learning.The department created new guidelines to help schools work to improve their technological infrastructure .The guidelines are also designed to help schools choose the right digital devices and set up policies for their proper use. \"We have to do more to offer our children a world-class education,\"Obama told the crowd of school leaders.\"We have to improve our education level if we are going to make sure that every child in America can go as far as their dreams and talents will take them.\" According to Cecilia Muoz,director of the Domestic Policy Council,less than 40% of public schools in America have high-speed Internet access in their classrooms.She believes that Connected will make America a leader in using technology to educate students. Muoz mentioned the Mooresville school district as a success story.Mooresville provides each student in grades 3 through 12 with a device,and uses a mostly digital subject.Muoz said Mooresville now ranks third in test scores and second in graduation rates in the state. At the end of the president's speech,1,200 school leaders attending the event signed the Future Ready District Pledge on their iPads.It promises the education leaders to help develop a culture of learning through technology at their schools,and to support teachers and students in using technology. \"Every child deserves a chance at a world-class education,\"Obama added.\"That's what makes our nation great.\"", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}198{"query": "The main chemical components of living organisms are known as organic compounds. Organic compounds are molecules built around the element carbon (C). Living things are made up of very large molecules. These large molecules are called macromolecules because macro means large; they are made by smaller molecules bonding together. Our body gets these smaller molecules, the \"building blocks\" or monomers, of organic molecules from the food we eat. Which organic molecules do you recognize from the list below? The four main types of macromolecules found in living organisms, shown in Table 1.1, are: 1. 2. 3. 4. Proteins. Carbohydrates. Lipids. Nucleic Acids. Proteins C, H, O, N, S Enzymes, muscle fibers, antibodies Elements Examples Monomer building molecule) (small block Amino acids Carbohydrates C, H, O Sugar, glucose, starch, glycogen, cellulose Monosaccharides (simple sugars) Lipids C, H, O, P Fats, oils, waxes, steroids, phospho- lipids in membranes Often include fatty acids Nucleic Acids C, H, O, P, N DNA, RNA, ATP Nucleotides Carbohydrates are sugars, or long chains of sugars. An important role of carbohydrates is to store energy. Glucose ( Figure 1.1) is an important simple sugar molecule with the chemical formula C6 H12 O6 . Simple sugars are known as monosaccharides. Carbohydrates also include long chains of connected sugar molecules. These long chains often consist of hundreds or thousands of monosaccharides bonded together to form polysaccharides. Plants store sugar in polysaccharides called starch. Animals store sugar in polysaccharides called glycogen. You get the carbohydrates you need for energy from eating carbohydrate-rich foods, including fruits and vegetables, as well as grains, such as bread, rice, or corn. A molecule of glucose, a type of carbohy- drate. Proteins are molecules that have many different functions in living things. All proteins are made of monomers called amino acids ( Figure 1.2) that connect together like beads on a necklace ( Figure 1.3). There are only 20 common amino acids needed to build proteins. These amino acids form in thousands of different combinations, making about 100,000 or more unique proteins in humans. Proteins can differ in both the number and order of amino acids. It is the number and order of amino acids that determines the shape of the protein, and it is the shape (structure) of the protein that determines the unique function of the protein. Small proteins have just a few hundred amino acids. The largest proteins have more than 25,000 amino acids. This model shows the general structure of all amino acids. Only the side chain, R, varies from one amino acid to another. KEY: H = hydrogen, N = nitrogen, C = carbon, O = oxygen, R = variable side chain. Many important molecules in your body are proteins. Examples include enzymes, antibodies, and muscle fiber. Enzymes are a type of protein that speed up chemical reactions. They are known as \"biological catalysts.\" For example, your stomach would not be able to break down food if it did not have special enzymes to speed up the rate of digestion. Antibodies that protect you against disease are proteins. Muscle fiber is mostly protein ( Figure 1.4). Muscle fibers are made mostly of protein. Its important for you and other animals to eat food with protein, because we cannot make certain amino acids on our own. You can get proteins from plant sources, such as beans, and from animal sources, like milk or meat. When you eat food with protein, your body breaks the proteins down into individual amino acids and uses them to build new proteins. You really are what you eat! Have you ever tried to put oil in water? They dont mix. Oil is a type of lipid. Lipids are molecules such as fats, oils, and waxes. The most common lipids in your diet are probably fats and oils. Fats are solid at room temperature, whereas oils are fluid. Animals use fats for long-term energy storage and to keep warm. Plants use oils for long- term energy storage. When preparing food", "pos": "Five characteristics are used to define life. All living things share these characteristics. All living things: 1. 2. 3. 4. 5. are made of one or more cells. need energy to stay alive. respond to stimuli in their environment. grow and reproduce. maintain a stable internal environment. Cells are the basic building blocks of life. They are like tiny factories where virtually all life processes take place. Some living things, like the bacteria in Figure 2.1, consist of just one cell. They are called single-celled organisms. You can see other single-celled organisms in Figure 2.2. Some living things are composed of a few to many trillions of cells. They are called multicellular organisms. Your body is composed of trillions of cells. Regardless of the type of organism, all living cells share certain basic structures. For example, all cells are enclosed by a membrane. The cell membrane separates the cell from its environment. It also controls what enters or leaves the cell. Everything you do takes energy. Energy is the ability to change or move matter. Whether its reading these words or running a sprint, it requires energy. In fact, it takes energy just to stay alive. Where do you get energy? You probably know the answer. You get energy from food. Figure {{ref|MS-LS-SE-02-03-Food|below}] shows some healthy foods that can provide you with energy. Just like you, other living things need a source of energy. But they may use a different source. Organisms may be grouped on the basis of the source of energy they use. In which group do you belong? Producers such as the tree in Figure 2.1 use sunlight for energy to produce their own food. The process is called photosynthesis, and the food is sugar. Plants and other organisms use this food for energy. Consumers such as the raccoon in Figure 2.1 eat plantsor other consumers that eat plantsas a source of energy. Some consumers such as the mushroom in Figure 2.1 get their energy from dead organic matter. For example, they might consume dead leaves on a forest floor. When a living thing responds to its environment, it is responding to a stimulus. A stimulus (stimuli, plural) is something in the environment that causes a reaction in an organism. The reaction a stimulus produces is called a response. Imagine how you would respond to the following stimuli: Youre about to cross a street when the walk light turns red. You hear a smoke alarm go off in the kitchen. You step on an upturned tack with a bare foot. You smell the aroma of your favorite food. You taste something really sour. It doesnt take much imagination to realize that responding appropriately to such stimuli might help keep you safe. It might even help you survive. Like you, all other living things sense and respond to stimuli in their environment. In general, their responses help them survive or reproduce. Watch this amazing time-lapse video to see how a plant responds to the stimuli of light and gravity as it grows. Why do you think it is important for a plant to respond appropriately to these stimuli for proper growth? MEDIA Click image to the left or use the URL below. URL: Like plants, all living things have the capacity for growth. The ducklings in Figure 2.4 have a lot of growing to do to catch up in size to their mother. Multicellular organisms like ducks grow by increasing the size and number of their cells. Single-celled organisms just grow in size. As the ducklings grow, they will develop and mature into adults. By adulthood, they will be able to reproduce. Reproduction is the production of offspring. The ability to reproduce is another characteristic of living things. Many organisms reproduce sexually. In sexual reproduction, parents of different sexes mate to produce offspring. The offspring have some combination of the traits of the two parents. Ducks are examples of sexually reproducing organisms. Other organisms reproduce asexually. In asexual reproduction, a single parent can produce offspring alone. For example, a bacterial cell reproduces by dividing into two daughter cells.", "neg": "Nutrients in the foods you eat are needed by the cells of your body. How do the nutrients in foods get to your body cells? What organs and processes break down the foods and make the nutrients available to cells? The organs are those of the digestive system. The processes are digestion and absorption. The digestive system is the body system that breaks down food and absorbs nutrients. It also gets rid of solid food waste. The digestive system is mainly one long tube from the mouth to the anus, known as the gastrointestinal tract (GI tract). The main organs of the digestive system include the esophagus, stomach and the intestine, and are pictured below ( Figure 1.1). The intestine is divided into the small and large intestine. The small intestine has three segments. The ileum is the longest segment of the small intestine, which is well over 10 feet long. The large intestine is about 5 feet long. This drawing shows the major organs of the digestive system. The liver, pancreas and gallbladder are also organs of the digestive system. Digestion is the process of breaking down food into nutrients. There are two types of digestion, mechanical and chemical. In mechanical digestion, large chunks of food are broken down into small pieces. Mechanical digestion begins in the mouth and involves physical processes, such as chewing. This process continues in the stomach as the food is mixed with digestive juices. In chemical digestion, large food molecules are broken down into small nutrient molecules. This is a chemical process which also begins in the mouth as saliva begins to break down food and continues in the stomach as stomach enzymes further digest the food. Absorption is the process that allows substances you eat to be taken up by the blood. After food is broken down into small nutrient molecules, the molecules are absorbed by the blood. After absorption, the nutrient molecules travel in the bloodstream to cells throughout the body. This happens mostly in the small intestine. Some substances in food cannot be broken down into nutrients. They remain behind in the digestive system after the nutrients are absorbed. Any substances in food that cannot be digested and absorbed pass out of the body as solid waste. The process of passing solid food waste out of the body is called elimination.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}199{"query": "One success story in reducing pollutants that harm the atmosphere concerns ozone-destroying chemicals. In 1973, scientists calculated that CFCs could reach the stratosphere and break apart. This would release chlorine atoms, which would then destroy ozone. Based only on their calculations, the United States and most Scandinavian countries banned CFCs in spray cans in 1978. More confirmation that CFCs break down ozone was needed before more was done to reduce production of ozone- destroying chemicals. In 1985, members of the British Antarctic Survey reported that a 50% reduction in the ozone layer had been found over Antarctica in the previous three springs. Two years after the British Antarctic Survey report, the \"Montreal Protocol on Substances that Deplete the Ozone Layer\" was ratified by nations all over the world. The Montreal Protocol controls the production and consumption of 96 chemicals that damage the ozone layer (Figure 1.1). Hazardous substances are phased out first by developed nations and one decade later by developing nations. More hazardous substances are phased out more quickly. CFCs have been mostly phased out since 1995, although were used in developing nations until 2010. Some of the less hazardous substances will not be phased out until 2030. The Protocol also requires that wealthier nations donate money to develop technologies that will replace these chemicals. Ozone levels over North America decreased between 1974 and 2009. Models of the future predict what ozone levels would have been if CFCs were not being phased out. Warmer colors indicate more ozone. Since CFCs take many years to reach the stratosphere and can survive there a long time before they break down, the ozone hole will probably continue to grow for some time before it begins to shrink. The ozone layer will reach the same levels it had before 1980 around 2068 and 1950 levels in one or two centuries.", "pos": "Human health suffers in locations with high levels of air pollution. Different pollutants have different health effects: Lead is the most common toxic material and is responsible for lead poisoning. Carbon monoxide can kill people in poorly ventilated spaces, such as tunnels. Nitrogen and sulfur-oxides cause lung disease and increased rates of asthma, emphysema, and viral infections such as the flu. Ozone damages the human respiratory system, causing lung disease. High ozone levels are also associated with increased heart disease and cancer. Particulates enter the lungs and cause heart or lung disease. When particulate levels are high, asthma attacks are more common. By some estimates, 30,000 deaths a year in the United States are caused by fine particle pollution. Many but not all cases of asthma can be linked to air pollution. During the 1996 Olympic Games, Atlanta, Georgia, closed off their downtown to private vehicles. This action decreased ozone levels by 28%. At the same time, there were 40% fewer hospital visits for asthma. Can scientists conclude without a shadow of a doubt that the reduction in ozone caused the reduction in hospital visits? What could they do to make that determination? Lung cancer among people who have never smoked is around 15% and is increasing. One study showed that the risk of being afflicted with lung cancer increases directly with a persons exposure to air pollution (Figure 1.1). The study concluded that no level of air pollution should be considered safe. Exposure to smog also increased the risk of dying from any cause, including heart disease. One study found that in the United States, children develop asthma at more than twice the rate of two decades ago and at four times the rate of children in Canada. Adults also suffer from air pollution-related illnesses that include lung disease, heart disease, lung cancer, and weakened immune systems. The asthma rate worldwide is rising 20% to 50% every decade.", "neg": "The Clean Air Act of 1970 and the amendments since then have done a great job in requiring people to clean up the air over the United States. Emissions of the six major pollutants regulated by the Clean Air Act carbon monoxide, lead, nitrous oxides, ozone, sulfur dioxide, and particulates have decreased by more than 50%. Cars, power plants, and factories individually release less pollution than they did in the mid-20th century. But there are many more cars, power plants, and factories. Many pollutants are still being released and some substances have been found to be pollutants that were not known to be pollutants in the past. There is still much work to be done to continue to clean up the air. Reducing air pollution from vehicles can be done in a number of ways. Breaking down pollutants before they are released into the atmosphere. Motor vehicles emit less pollution than they once did because of catalytic converters (Figure 1.1). Catalytic converters contain a catalyst that speeds up chemical reactions and breaks down nitrous oxides, carbon monoxide, and VOCs. Catalytic converters only work when they are hot, so a lot of exhaust escapes as the car is warming up. Catalytic converters are placed on mod- ern cars in the United States. Making a vehicle more fuel efficient. Lighter, more streamlined vehicles need less energy. Hybrid vehicles have an electric motor and a rechargeable battery. The energy that would be lost during braking is funneled into charging the battery, which then can power the car. The internal combustion engine only takes over when power in the battery has run out. Hybrids can reduce auto emissions by 90% or more, but many models do not maximize the possible fuel efficiency of the vehicle. A plug-in hybrid is plugged into an electricity source when it is not in use, perhaps in a garage, to make sure that the battery is charged. Plug-in hybrids run for a longer time on electricity and so are less polluting than regular hybrids. Plug-in hybrids began to become available in 2010. Developing new technologies that do not use fossil fuels. Fueling a car with something other than a liquid organic-based fuel is difficult. A fuel cell converts chemical energy into electrical energy. Hydrogen fuel cells harness the energy released when hydrogen and oxygen come together to create water (Figure 1.2). Fuel cells are extremely efficient and they produce no pollutants. But developing fuel-cell technology has had many problems and no one knows when or if they will become practical. Pollutants are removed from the exhaust streams of power plants and industrial plants before they enter the atmo- sphere. Particulates can be filtered out, and sulfur and nitric oxides can be broken down by catalysts. Removing these oxides reduces the pollutants that cause acid rain. Particles are relatively easy to remove from emissions by using motion or electricity to separate particles from the gases. Scrubbers remove particles and waste gases from exhaust using liquids or neutralizing materials (Figure 1.3). Gases, such as nitrogen oxides, can be broken down at very high temperatures. A hydrogen fuel-cell car looks like a gasoline-powered car. Scrubbers remove particles and waste gases from exhaust. Gasification is a developing technology. In gasification, coal (rarely is another organic material used) is heated to extremely high temperatures to create syngas, which is then filtered. The energy goes on to drive a generator. Syngas releases about 80% less pollution than regular coal plants, and greenhouse gases are also lower. Clean coal plants do not need scrubbers or other pollution control devices. Although the technology is ready, clean coal plants are more expensive to construct and operate. Also, heating the coal to high enough temperatures uses a great deal of energy, so the technology is not energy efficient. In addition, large amounts of the greenhouse gas CO2 are still released with clean coal technology. Nonetheless, a few of these plants are operating in the United States and around the world. How can air pollution be reduced? Using less fossil fuel is one way to lessen pollution. Some examples of ways to conserve fossil fuels are: Riding a bike or walking instead of driving", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}200{"query": "While Clostridium difficile epidemiology is well documented in many European countries, data are largely missing for South Eastern European region. Here we report the PCR ribotype distribution of 249 C.difficile isolates received for typing from six hospital settings from Croatia, Bosnia and Herzegovina, Republic of Macedonia and Serbia in time period from 2008 to 2015. Twenty-four PCR ribotypes were detected. The majority of strains from Bosnia and Herzegovina and Serbia belonged to PCR ribotype 027 (65.8%). Other three dominating PCR ribotypes were 176 (18 strains; Croatia), 001/072 (15 strains; all countries) and 014/020 (15 strains; all countries).", "pos": "Epidemiology of Clostridium difficile is characterized by worldwide increase of C. difficile infections (CDI) and the emergence of new epidemic outbreak strains with the capacity for global spreading. Long-term local surveillance at the University of Saarland Medical Center between 2000 and 2013 shows that the incidence rate of laboratory-confirmed CDI was influenced by local epidemiology as well as by testing strategies. Since 2008, molecular typing of C. difficile was regularly performed for symptomatic hospitalized patients by surface-layer protein A sequence typing (slpAST), which is an established highly standardized technique for genotyping of C. difficile. The results were assigned to known ribotypes for better comparison to international data. It could be demonstrated that distribution of genotypes was different between age groups. Older patients were predominantly infected with ribotype 001 and 027, whereas ribotype 027 was not detected in the pediatric population. Molecular typing of German isolates sent to the advisory laboratory between 2011 and 2013 revealed that ribotype 027 is present with high percentages in most German regions except for the very North. In conclusion, optimized testing of all hospitalized patients with diarrhea should be generally implemented to avoid under-diagnosis of C. difficile infection. Ribotype 027 is highly prevalent in Germany, but its infections are restricted to older patients, while absent in children. Molecular typing of suspected hospital outbreaks and of patients with severe or recurrent disease may help to better understand virulence and epidemic spreading of C. difficile.", "neg": "Clinical evidence for failure with beta-lactam therapy has been lacking for patients with borderline oxacillin-resistant Staphylococcus aureus (BORSA) infections. We describe a failure of cloxacillin for a patient with endocarditis due to BORSA. The isolate also had false-negative thermonuclease and coagulase test results.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}201{"query": "This article needs an improved plot summary. (November 2015) Sidhu (Akshay Kumar) is a lowly vegetable cutter at a roadside food stall in the Chandni Chowk section of Delhi, who consults astrologers, tarot card readers, and fake fakirs despite his foster father Dada's (Mithun Chakraborty) exhortations. When two strangers from China claim him as a reincarnation of war hero 'Liu Shen' and take him to China, Sidhu, encouraged by trickster Chopstick (Ranvir Shorey), believes he will be feted as a hero, unaware of his own recruitment to assassinate the smuggler Hojo (Gordon Liu). Sidhu travels to China with Chopstick. Along the way he meets Sakhi (Deepika Padukone), the Indian-Chinese spokesmodel known as Ms. Tele Shoppers Media, or Ms. TSM, who also appears in China. Her twin sister Suzy, known as the femme fatale Meow Meow, works for Hojo, not knowing Hojo tried to kill her father, Inspector Chiang (Roger Yuan). Sidhu, through a series of accidents, initially eludes Hojo, but Hojo eventually exposes him as a fraud. Thereupon Hojo kills Dada, and Sidhu is beaten and urinated on by Hojo. Injured and disgraced Sidhu vows revenge. He thereafter encounters an amnesiac vagrant, whom he later identifies to Sakhi as Inspector Chiang. Chiang later recovers his memory and trains Sidhu in kung fu. When Hojo again meets with Sidhu, Suzy injures Chiang; but upon seeing Sakhi, betrays Hojo. Sidhu fights Hojo in single combat, eventually using a modified vegetable-cutting technique to overwhelm him. In the aftermath, Sidhu opens a vegetable stall in China, but is recruited to fight for some African pygmies. The film thereupon concludes with the announcement \"To be Continued Chandni Chowk to Africa\".", "pos": "The film opens in North Africa, 1600, with the English mercenary Solomon Kane as he leads his ship's crew into battle against the Ottoman occupiers of a fortress town. After defeating the defenders, Kane and his men raid the fortress, where most of the crew are killed by demons. Kane fights his way to the throne room, but, before he can loot the riches, he is confronted by a demon that tells him his soul is forfeit to Satan. Solomon rejects his fate and jumps out a window. Following this encounter, Solomon returns to England and finds sanctuary in a monastery. After a prophetic dream, the abbot apologetically expels Kane, and Kane travels by foot to his ancestral estate, from which he had been expelled in his youth after defying his father. Along the way, he is ambushed by robbers who mock his vow of pacifism and leave him for dead. He is found and treated by the Crowthorns, a family of Puritans traveling west to the New World. When the Crowthorns are slaughtered by corrupted followers of the evil sorcerer Malachi, Kane renounces his vows and swears to avenge their deaths and rescue Meredith Crowthorn, who has been marked by a witch and kidnapped by the Masked Rider, Malachi's lieutenant. Kane battles Malachi's followers across the countryside, rescuing many captives but not finding Meredith. On his journey, he meets a deranged priest who explains Malachi's followers are taking the weaker survivors of their raids as slaves and corrupting the strong into soldiers. The priest tries to feed Kane to his parishioners, who have become ghouls, but Kane escapes, only to face the robbers who attacked him earlier, now corrupted servants of Malachi. He kills two of the robbers and interrogates the survivor, who tells Solomon that Meredith is dead. Kane throws the robber to the ghouls, and, believing his quest for redemption has failed, drinks to excess at a country inn. Former shipmates recognise him and try to recruit him as a leader of a resistance against Malachi, but Kane refuses. Malachi's followers attack the inn at dawn and crucify the leaders of the resistance, including Kane. As Kane hangs on the cross, Meredith cries out his name from her cage in the back of the raiders' wagon; Kane realises that he still has a chance to save her and pulls himself free. Before Malachi's remaining men can finish him, they are killed by survivors of the resistance, who take Kane to safety. Kane is healed by an old witch and is soon anxious to confront the raiders. The resistance explain Malachi's background as a former healer who made a bargain with the Devil, and reveal that he now lives in Kane's ancestral home. Kane leads them into the castle via an underground passage, and, as the resistance fights Malachi's soldiers, Kane heads for the dungeons and frees many of the captives. There he finds not Meredith but his father, who explains that the Masked Rider is Kane's older brother Marcus, whom Kane thought he had accidentally killed after his banishment. Instead, Marcus was critically injured, and, when healers failed to revive him, his father turned to Malachi. Disfigured and turned to Malachi's will, Marcus becomes the Masked Rider. Solomon reluctantly acquiesces to his father's request and kills him, then heads to the throne room to confront Malachi. There, Kane finds Meredith in a cage, and as she warns him of a trap, Marcus stabs him in the back. Kane tries to reason with Marcus, but they engage in a duel; Kane wins after setting Marcus on fire and decapitating him. Malachi uses Meredith's blood to release a demon sent to claim Kane's soul, but Kane shoots Malachi dead and sacrifices himself to close the portal. Meredith believes Kane to be dead, but he awakens and explains that he has finally redeemed his soul. Kane reunites Meredith with her remaining family and buries his father and brother. In a final voice-over, he declares his intention to roam the Earth and oppose the forces of darkness.", "neg": "Chettinad Palace in Karaikudi seen in the film. Natesan (Cheran) works as an engineer in electricity board in Karaikudi and leads a joint family with more 30 of his relatives living in the same house. On the other hand, Visalakshi aka Sala (Sneha) is the only daughter to her parents and she is about to complete her college education in Karaikudi. Sala feels bored while being alone and she always prefers to have her friends surrounding her. Sala's parents start searching for a groom and they get a reference for Natesan. Sala and her family meet Natesan's family in a function. Sala is surprised to see so many people living as a joint family together and she is very much impressed and agrees for the wedding. Natesan and Sala get married. Sala loves being accompanied by all the relatives in Natesan's home. When Sala and Natesan go on a honeymoon, Sala purchases gifts for everyone in the family. All the family members are also impressed seeing Sala. But Natesan feels sad that he does not get private time to spend with his wife as they are always surrounded by relatives. Now Natesan gets transferred to a hill station named Attakatti, near Pollachi. Natesan feels happy as he believes this will provide him time to spend with Sala. Although Sala feels sad leaving all her relatives, she also goes with Natesan to the hill station. Over there in the hill station, Sala feels lonely and gets bored and she longs for the life she had in Karaikudi. Their house is located in a remote place with no neighbours and friends. Natesan also gets busy with work and has very little time to spend with his wife. Slowly Sala gets psychologically disturbed due to loneliness and she behaves as if the house is filled with so many people. Also, she repairs the fan, lights etc. purposefully in their home so that the nearby electrician (Kanja Karuppu) comes to fix them and at least she gets a chance to speak to someone. She also starts recording all the sounds around her such as birds chirping, etc. and listens to the recordings when alone. One day, she records a neighbour's child's laughter sound following which the child faints. Sala is scared but the child is saved. Doctor Ramalingam (Jayaram) sees Sala and understands that she is suffering from a disorder and warns Natesan. But Natesan does not take it seriously. One day Sala consumes too much of sleeping pills to come out of her depression. But Natesan spots her lying in bed and rushes her to the hospital. Sala is saved. Ramalingam explains the disorder to Natesan and mentions that the best cure for her would be to lead a happy life surrounded by relatives. Natesan agrees and moves back to Karaikudi. The movie ends showing Natesan and Sala leading a happy life again.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}202{"query": "Alejandro Adem is a professor in the Department of Mathematics at the University of British Columbia since 2005 and the holder of a Canada Research Chair at UBC.", "pos": "James R. Redmond is Emeritus Professor of Zoology in the Iowa State University department of Ecology, Evolution and Organismal Biology.", "neg": "Founded in 1886, the Royal British Columbia Museum consists of The Province of British Columbia's natural and human history museum as well as the British Columbia Provincial Archives.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}203{"query": "The Exquisite Thief is a 1919 American silent drama film directed by Tod Browning.", "pos": "Dough and Dynamite is a 1914 American comedy silent film made by Keystone Studios starring Charlie Chaplin.", "neg": "Min and Bill is a 1930 American Pre-Code comedy-drama film starring Marie Dressler and Wallace Beery and based on Lorna Moon's novel Dark Star, adapted by Frances Marion and Marion Jackson.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}204{"query": "Doug (Barry Sullivan) and Helen Stilwin (Barbara Stanwyck) head off for a fishing vacation with their son Bobby (Lee Aker). Doug wants to return to beach he visited years before. The family is towing a small trailer with camping gear so they can fish and camp on the isolated beach south of Escondido in Mexico.As they leave drive, they get farther away from towns, services, and civilizations. When they need water for the cars radiator, they can only find a deserted service station. They leave the main road and encounter a police block. After a quick scan of the car, the Mexican authorities let them proceed, with no explanation for why they were stopped. When Helen asks Doug why he didn't push for an explanation, he tells her he didn't want them to look too closely at the car. He didn't want to explain why he was carrying his army pistol. Helen puts the gun in the glove box and they proceed.When they arrive at the beach, it is indeed isolated. An old, rotting jetty emerges far out into the water. As Doug and Helen are getting settled in and relaxing, Bobby climbs out to the jetty's end. Helen is worried the jetty is not safe and frantically calls Bobby back. As he return, his foot slips and is caught between two planks. Doug goes out to free him. As they are walking back over the precarious timbers, a large wave combined with Doug's weight causes the jetty to fall. Doug is trapped on the beach, his foot stuck under a timber too large to move.Helen tries to dig Doug out with a shovel, but the beach is solid rock. She retrieves the car jack and nearly has the large timber raised when the pin in the jack breaks. Doug and Helen decide that with a sturdy rope, she can pull the timber with the car. Helen will have to drive back to the deserted service station to find a rope. They estimate that Helen should have four hours before the rising tide covers Doug completely, threatening to drown him. Bobby stays with Doug and makes him a cup of coffee. Bobby tries unsuccessfully to wave down a fishing boat. When all hope is nearly gone, Doug and Bobby have a serious father and son talk about what should happen if Helen does not return in time.Helen races down the road. When she encounters a Mexican family, she pleads for help or a rope, but they do not understand her poor attempt at Spanish until she is gone. She reaches the service station and breaks into the building and retrieves a rope. As she returns to the car, she is relieved to see Lawson (Ralph Meeker), an American man, suddenly standing by her car. She quickly enlists his help and they head for the beach to save her husband. As they pull away with Lawson in the drivers seat, the camera shows a dead man lying in the bushes.Lawson soon reveals that he has no intention of helping her husband. He is running from the police. He finds the gun in the glove compartment and holds the gun on her while they pass the police. While he is speeding down the rough roads, they have a flat tire. Lawson is unable to find the jack, but manages to drive the car up onto a ramp made of abandoned boards. After he changes the tire, Helen tries to hit him with a tire iron, but he is able to fight her off. He escapes capture again, but this time has to fire the gun at a police car pursuing him. Realizing that she cannot overpower Lawson, Helen begins to bargain with him. Helen promises Lawson her husband's clothes, his identification card, and the car if only Lawson will help free her husband. Finally, she offers him what he really wants: she will go with him after they free his husband. Traveling as couple and with her husband's identification, they will more easily get by the police. She will do anything to save her husband's life.Once they arrive at the beach, the situation is dire. The rising tide", "pos": "Brilliant but irresponsible scientist Tony Nelson (James Congdon) develops an electronic amplifier that he hopes will allow any object to achieve a 4th dimensional (4D) state. While in this state that object can pass freely through any other object. However, Tony failed to pay attention to the overload, which sparks an electrical fire that burns down his lab, resulting in the university terminating his contract. Now unemployed, Tony seeks out his brother Scott (Robert Lansing), a researcher working on a material called cargonite that is so dense as to be impenetrable, to help him with his experiment. Scott is underpaid and unappreciated at his job but does not have the drive to challenge his employer, Mr. Carson, for greater recognition, especially since Scott has been the driving force behind the development of cargonite (named after Carson, showing he is grabbing much of the credit for Scott's work). When his girlfriend (Lee Meriwether) falls for Tony, an enraged Scott steals Tony's experiment and starts playing with it, eventually sending himself into a 4D state. When demonstrating this to Tony, Scott does not turn on the amplifier power yet successfully passes his hand through a block of steel, meaning Scott can now enter the 4D state via his own will. Tony is amazed but warns Scott not to reveal this until he can further test it for any side effects. While in the 4D state, Scott can pass through any solid object. The downside is that, while in that state, Scott ages at a greatly accelerated rate. He soon learns how to survive however, when an aged Scott visits the company doctor, who, while examining him, suddenly drops dead. Simply by touching others, Scott can drain their lifeforce, thereby rejuvenating himself. One night, Scott experiments with his abilities by being able to shoplift a piece of fruit from a grocery store window. Scott also notices a diamond necklace on display in a jewelry store window, but decides against stealing it. However, when Scott sees the bank, his face breaks into a sly grin. The police are wondering about a bizarre crime, over $50,000 was stolen from the bank with no forced entry nor video footage of wrongdoing, and a $20 bill was found protruding from a piece of tempered steel. Tony realizes Scott is abusing his power and tries to convince the police of the experiment. Scott starts using his new found power to acquire all the things he felt he was denied: money, recognition, power, and women. Scott then confronts Mr. Carson, revealing the experiment, then taking his revenge \"for the life drained from me\" by literally draining Carson's life force to rejuvenate his. After killing Carson, Scott then proceeds to a sleazy bar. He gets some toughs to back down, and his new found bravado combined with his ill-gotten money to impress a bar girl. Later in a car, when they kiss, Scott does not kill her, but drains her life force to the point where she becomes old, frightening her into running away. The police have to find a way to stop a man who is practically unstoppable. Looking old now, Tony returns to the nuclear lab where they are also unable to stop him. The girlfriend catches him when he is solid and shoots and wounds Scott after they kiss (which does not drain her life force). Bleeding and feeling betrayed, Scott maniacally proclaims his invincibility and defiantly phases his body through a wall embedded with supposedly impenetrable cargonite, his hand, slowly and with seeming difficulty, phasing lastly through the wall. \"The End\" then appears on the screen. A moment later, a question mark appears turning the closing phrase into an interrogative statement leaving into question whether Scott has died or survived.", "neg": "Gloria Mundy (Goldie Hawn) is attending a party in a town across the bay from San Francisco. From a conversation with a friend we learn that she is recently divorced and is shying away from dating men to avoid getting her heart broken again. Her friend urges her to become more social and for a few seconds she considers getting to know a stranger at the party played by Chevy Chase. Deciding he is a klutz and a bore she drives back to the city alone. As the opening credits roll we see her driving down the gorgeous Marlin County coastline in her yellow VW convertible as Barry Manilow sings the song \"Ready to Take a Chance Again.\"When Gloria passes a handsome stranded stranger with broken down car, she decides to take a chance and pulls over to help. The stranger, Bob Scott (Bruce Solomon) asks her to drive him back to the city. On the way Scott notices that they are being followed by a black limo and decides to slip a cigarette pack, containing a spool of film, into Gloria's purse asking her to meet him at a movie theater later that evening. When she drops him off, we see two men jump from the limo and pursue him.When Scott finally reaches the movie theater, he sits down and we see he is hurt and bleeding badly. He dies shortly after whispering to Gloria \"Beware of the dwarf!\" She runs from the theater and gets the manager, but by the time they get back to her seat, the body is gone.Gloria tells this story to her elderly landlord Mr. Hennessey (Burgess Meredith), a retired anthropologist who keeps a ten foot snake as a pet, then heads upstairs to go to bed. The next day when she goes to work at the public library she also tells this story to her girlfriend, Stella, (Marilyn Sokol) who is convinced the whole thing is a hoax by a sex-crazed man, and insists the Gloria protect herself by carrying a portable alarm and a can of mace in her purse.As she is closing up the library that evening Gloria finds herself alone with an albino stranger (William Frankfather) who tries to kidnap her. She flees the building with the albino and another swarthy character, The Turk (Ion Teodorescu) in pursuit. Running into a bar she picks up Stanley Tibbets (Dudley Moore) and without telling him whats going on, asks him to take her to his apartment. There, Stanley misreads her intentions and prepares for a wild evening of sex, while she is distracted watching her pursuers out the window. When she finally turns around and sees Stanley in his underwear she is shocked and he is embarrassed. She heads home while Stanley mutters his apologies.Gloria is later assaulted at her apartment by a man with a scar on his face (Don Calfa), who demands she give him whatever was passed to her by Scott. He takes the cigarettes, and then attempts to strangle Gloria, but she stabs him with a pair of knitting needles (The cigarettes fall out of his pocket and lay hidden under a plant). Thinking she has killed him she calls the police, but as she turns around he is up again staggering toward her with murderous intent. The albino suddenly appears at the window and uses a throwing knife to kill the man with the scar and Gloria faints.She awakes to see the face of Chevy Chase's character, who we find is police Lt. Tony Carlson. Gloria tells him her story, but again the body has disappeared. Carlson's partner, Fergie, (Brian Dennehy) thinks she is nuts, but Tony is attracted to her and invites her to the station during her lunch hour.When she leaves the library to meet Tony for lunch she is kidnapped by the albino and the Turk. Waking up locked in a room she uses the portable alarm to get the Turk into the room and then maces him. She then climbs down the fire escape in the pouring rain and jumps to safely. Later she shows up at Tony's office, soaked to the skin and he takes her home.The next day Tony and Fergie check out the room", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}205{"query": "Tony Scott died on 19 August 2012, committing suicide by jumping off the Vincent Thomas Bridge in San Pedro, California.", "pos": "Ivan Francescato died suddenly of a heart attack at 3 a.m. at his home in Treviso.", "neg": "The Van Gogh Museum's Wheatfield with Crows was painted in July 1890, in the last weeks of van Gogh's life.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}206{"query": "Opening narrationAn explanation that our knowledge of Venus is very incomplete and only by imagination can we glimpse the planet, but the producers of the film believe the heroic Soviet people will see the planet with their own eyes.Opening sceneThree soviet spaceships CCCP Sirius Vega and Capella approach Venus after completing a 200 million kilometer journey. Suddenly before anyone can react Capella is destroyed with all hands by a stray meteor. The crew of the Sirius are devastated by the news, and reflect on how close they came only to die within sight of their destination. A message received from Earth advises that a replacement for Capella is launching soon and will reach Venus in 4 monthsAlexi ( ) one of the crew from Sirius doesnt want to wait and suggests they modify the robot glider on Vega, so. Venus needs to be seen by human eyes. He explains if anything happens he will not call for help. His life is his, to do with as he desires.Mr Kern (Georgi Tejkh) On board Vega must have the final say on the launch. Rather than use the glider he recommends landing the two ships rather than wait for the spare ship from Earth, but first he has to check the figures for the safety margins. To do this he activates the ships robot JohnThe robot proposes a different plane. Three crew members go down in the glider, three more go down in the Sirius, leaving Vega in orbit manned by Masha (Kyunna Ignatova) Masha feels cheated by the plan but realizes it is the only way the mission can succeed As they plan to land a strange red light is seen through the cloud cover. They decide to try and land close to that position. It is decided the glider will go down first, and try and identify a good landing place. Sirius will followThe glider finds a location but as it drops the beacon to mark the spot for Sirius it is blown off course and heads for a dangerous landing in a swampy region. From orbit Sirius cant re-establish contact. Unsure what may have happened Sirius decides to land at the beacon and try and find the crew of the gliderThe Sirius lands successfully and begins testing the environment to see if they can go outside. Using an external microphone they listen to the sounds of Venus. At one point they hear what sounds like a womans voice singing. Understanding that little can be accomplished from the ship they decide to outside and explore. As Alexi explores away from the ship he is attacked by some strange tentacle creature. The other crew dont realize the danger and continue to check instruments for signs of the glider. They discover two distinct signals. One they suspect is the glider, and one that is moving should be JohnFinally the others realize Alexis situation and rescuing him from the plant like creature. The creature responds by first releasing Alexi then encloses itself in a protective shellIn the meantime Masha has confirmed the other crew is alive and has pin-pointed their location, approximately 32 kilometers away. The fact John is active proves crew members must have survived because hed been disassembled for the flight downAt the other landing site Kern, working with the partially completed robot search for parts of the robot to complete the job of assembly. One of the other crew is firing ant strange reptilian creatures that keep attacking Meanwhile the crew of Sirius have gotten their rover working and set off to help the crew of Vega. On the way they see a brontosaurs and stop to take a blood sample from the slow moving creature. While doing this, Masha confirms that the Vegas crew is moving towards the Sirius location.The crew from the Vega begin to feel ill and fevered, they are concerned that the rips in their suit may have allowed them to get sick from Venusians germs. The crews of the Sirius reach the shore of a large body of water and decide to cross it rather than go around. As they prepare to submerge they hear the same strange womans voice. Pausing to investigate, they find nothing and press onBack with the Vega crew they have been caught in a rain storm and John cautions that he may soon malfunction because of the water. Schebra (Yuri Sarantsev) Is", "pos": "The opening crawl reveals that Han Solo's friends are engaged in a mission to rescue the smuggler from Jabba the Hutt and that the Galactic Empire is building a new armored space station which is even larger and more powerful than the first Death Star.Near the forest moon of Endor the new Death Star is being constructed in orbit, and a command star destroyer arrives and launches a shuttle with a fighter escort -- a shuttle bearing the Dark Lord of the Sith. Fearing his arrival, the commander of the new Death Star informs Darth Vader (David Prowse, voice: James Earl Jones) that the station will be operational on schedule, but when Vader challenges this \"optimistic\" appraisal of the situation, the commander admits that he needs more men to accelerate construction. Darth Vader, however, informs the commander that the Emperor (Ian McDiarmid) will be arriving soon, and that he is most displeased with the commander's progress. Shaken, the commander commits to redoubling construction efforts. Vader, pleased, remarks, \"the Emperor is not as forgiving as I am.\"Jedi Knight Luke Skywalker (Mark Hamill), Chewbacca (Peter Mayhew), Lando Calrissian (Billy Dee Williams), Princess Leia Organa (Carrie Fisher), C-3PO (Anthony Daniels), and R2-D2 (Kenny Baker) return to Tatooine to rescue Han Solo (who was encased in carbonite at the end of Star Wars: Episode V - The Empire Strikes Back) from the gangster Jabba the Hutt (voice: Larry Ward). Luke sends C-3PO and R2-D2 to Jabba's desert palace to deliver a message: In a hologram projected by R2, Luke offers to bargain with Jabba for Solo himself -- if Jabba does not, he will be destroyed. Jabba laughs at the message and refuses to give up his \"favorite decoration:\" Han, frozen in carbonite, hangs on a wall in Jabba's court. The two droids are sent to EV-9D9's workshop where C-3P0 is given the job of Jabba's translator and R2 will be a drink-server on Jabba's sail barge.Disguised as a bounty hunter named Boushh, Leia arrives in Jabba's court with Chewbacca in cuffs. She offers him to Jabba for a sizable bounty. After Leia dickers with Jabba over the amount and threatens him with a small thermal detonator, Jabba happily agrees to pay, impressed with the bounty hunter's nerve, and Chewbacca is imprisoned.That night, Leia sneaks into Jabba's court and frees Han from the carbonite. However, she and Solo are both captured by Jabba. Solo is imprisoned with Chewbacca and Jabba keeps Leia on display in a metal bikini and chains. Luke arrives with a final ultimatum to release Solo. Jabba again refuses and drops Luke through a trap door into a pit below his throne that houses the rancor, a fearsome beast that Jabba keeps for executions. As Leia watches in horror, she sees Lando Calrissian disguised as a palace guard. After a brief battle, Luke defeats the rancor, enraging Jabba, who declares that Luke, Solo and Chewbacca will be slowly consumed by the sarlacc -- a huge, shark-toothed, tentacled maw at the bottom of the Great Pit of Carkoon.The group is taken to the pit on Jabba's sail barge fleet and prepared for execution: Luke is the first, pushed out onto a thin plank over the pit. Luke gives R2 a short salute and a small object, Luke's new lightsaber, is launched into his hand. A battle erupts, with Luke steadily taking the fight to Jabba's men. During the battle, Leia strangles Jabba with the chain around her neck and with R2-D2's help escapes from her bonds. Solo accidentally knocks Boba Fett (Jeremy Bulloch) into the sarlacc pit. Lando is also thrown off one of the skiffs, hanging by a few cables until he's rescued from the sarlacc itself by Han and Chewbacca. Luke, having fought his way onto Jabba's sail barge, has the escaping Leia aim the deck cannon at the vehicle and sets it on automatic fire; the sail barge soon blows apart. Our heroes manage to escape before it explodes, retrieve R2 and C-3PO and zip off into the desert.", "neg": "This film is based on the popular pulp novel series Perry Rhodan. The story begins with the spacecraft Stardust being launched from Earth to explore the moon in an attempt to discover new deposits of a new element, much more powerful than Uranium or any other source of energy ever discovered. The plot takes a split approach with the Stardust being taken over by a mysterious force, causing it to land on the Dark side of the Moon, and out of contact with Earth. Meanwhile on earth, an organized crime boss has planted an agent amongst the crew of the Stardust to attampt to take the energy source somhow, if it is found. Soon Perry Rhodan and his crew discover an alien starship which has had to make an emergency landing on the Moon due to technical problems. The ship is commanded by the Alien Crest and the beautiful captain Thora. They are informed that Crest, one of the last great scientists of their dying civilization is very ill.The Stardust's Doctor is asked to examine Crest and he does, and discovers Crest has Lukemia. There is hope however. The Doctor knows of a researcher on Earth who has developed a cure for Lukemia. The crew of the Stardust are brought along in a smaller but very capable emergency craft, to Earth, in an attempt to enlist the Researchers aid to cure crest. What they don't know however is that the spy has informed the crimelord about the mission, and a trap has been set to capture Crest and the Arkonide ship on the moon. There is a lot of true 60s style action as a General who discovered the pilot ship on earth, attempts to capture it to no avail. Afterwards Major Rhodan and his co-pilot seek out and recruit the fake researcher who promptly attempts to take over the Arkonite ship. The crimelord is defeated however, with the aid of the robots that the Arrkonites use to run the day to day operations of their ships, and the real researcher is rescued and cures Crest. The final segment has Major Perry Rhodan rescuing Thora, who had been temporarily captured by the crimelord. At the end, the very militant and strong willed Thora falls for Major Rhodan's charms and the two races (after curing Crest) look forward to a long and trusted partnership.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}207{"query": "The aim of this study was to elucidate the role of lysyl oxidase (LOX) and lysyl oxidase like (LOXL) 2 in pathologic wound healing after glaucoma surgery. We therefore investigated the expression of LOX and LOXL2 and evaluated the therapeutic potential of anti-LOX (GS-639556, formerly M64) and anti-LOXL2 (GS-607601, formerly AB0023) antibodies in a rabbit model of glaucoma trabeculectomy. Ocular expression of LOX and LOXL2 was investigated by immunohistologic staining at different time points after trabeculectomy. Treatment with GS-639556 or GS-607601 was initiated in rabbits immediately after trabeculectomy by giving both intracameral and subconjunctival injections. Thereafter, the antibodies were given twice a week subconjunctivally until day 30 after surgery (day of euthanization). Treatment outcome was studied by clinical investigation of the bleb and by immunohistochemical analysis of angiogenesis, inflammation, and collagen deposition. LOX and LOXL2 were both upregulated in Tenon's capsule and the conjunctiva after glaucoma surgery. Repeated administration of LOX- or LOXL2-targeting monoclonal antibodies increased bleb area and bleb survival. Analyses of immunohistologic stainings showed that both antibodies significantly decreased fibrosis, whereas the anti-LOXL2 antibody also significantly reduced blood vessel density and inflammation. Targeting LOXL2 with an inhibitory monoclonal antibody (GS-607601) reduced pathologic angiogenesis, inflammation, and fibrosis. These results suggest that LOXL2 could be an appealing target for treatment of scar formation after glaucoma surgery, and point to the potential therapeutic benefits of simtuzumab, a humanized monoclonal antibody derived from GS-607601.", "pos": "Lysyl oxidase-like 2 (LOXL2) catalyses collagen cross-linking and is implicated in the pathogenesis of idiopathic pulmonary fibrosis (IPF). The aim of this study was to investigate the efficacy and safety of simtuzumab, a monoclonal antibody against LOXL2, in patients with IPF. In this randomised, double-blind, phase 2 trial, we recruited patients aged 45-85 years with definite IPF diagnosed prior to 3 years of screening from 183 hospitals and respiratory clinics in 14 countries. Eligible patients, stratified by baseline forced vital capacity (FVC), serum LOXL2 (sLOXL2) concentrations, and pirfenidone and nintedanib use, were randomly assigned (1:1) to inject 125 mg/mL simtuzumab or placebo subcutaneously once a week. The primary endpoints were progression-free survival, defined as time to all-cause death or a categorical decrease from baseline in FVC % predicted, in the intention-to-treat population, in patients with sLOXL2 concentrations in the 50th percentile or higher, and in patients with sLOXL2 concentrations in the 75th percentile or higher. Treatment duration was event-driven, and interim analyses were planned and conducted after approximately 120 and 200 progression-free survival events, respectively, occurred. We compared treatment groups with the stratified log-rank test. This study is registered with ClinicalTrials.gov, number NCT01769196. Patients with IPF were recruited between Jan 31, 2013, and June 1, 2015. The intention-to-treat population included 544 randomly assigned patients (272 patients in both groups), and the safety population included 543 randomly assigned patients who received at least one dose of study medication. The study was terminated when the second interim analysis met the prespecified futility stopping criteria in the intention-to-treat population. We noted no difference in progression-free survival between simtuzumab and placebo in the intention-to-treat population (median progression free survival times of 126 months and 154 months for simtuzumab and placebo, respectively; stratified HR 113, 95% CI 088-145; p=0329) and in patients with baseline sLOXL2 in the 50th percentile or higher (median progression-free survival 117 months and 143 months for simtuzumab and placebo, respectively; stratified HR 103, 95% CI 074-143; p=0851), or in the 75th percentile or higher (median progression-free survival 116 months and 169 months for simtuzumab and placebo, respectively; stratified HR 120, 95% CI 072-200; p=0475). The incidence of adverse events and serious adverse events was similar between treatment groups. The most common adverse events in both the simtuzumab and placebo groups were dyspnoea, cough, upper respiratory tract infection, and worsening of IPF; and the most common grade 3 or 4 adverse events were worsening of IPF, dyspnoea, and pneumonia. Simtuzumab did not improve progression-free survival in a well-defined population of patients with IPF. Our data do not support the use of simtuzumab for patients with IPF. Gilead Sciences Inc.", "neg": "LYST is a large cytosolic protein that influences the biogenesis of lysosome-related organelles, and mutation of the encoding gene, LYST, can cause Chediak-Higashi syndrome. Recently, Lyst-mutant mice were recognized to also exhibit an iris disease resembling exfoliation syndrome, a common cause of glaucoma in humans. Here, Lyst-mutant iris phenotypes were used in a search for genes that influence Lyst pathways. In a candidate gene-driven approach, albino Lyst-mutant mice homozygous for a mutation in Tyr, whose product is key to melanin synthesis within melanosomes, exhibited complete rescue of Lyst-mutant iris phenotypes. In a genetic background-driven approach using a DBA/2J strain of congenic mice, an interval containing Tyrp1 enhanced Lyst-dependent iris phenotypes. Thus, both experimental approaches implicated the melanosome, an organelle that is a potential source of oxidative stress, as contributing to the disease phenotype. Confirming an association with oxidative damage, Lyst mutation resulted in genetic context-sensitive changes in iris lipid hydroperoxide levels, being lowest in albino and highest in DBA/2J mice. Surprisingly, the DBA/2J genetic background also exposed a late-onset neurodegenerative phenotype involving cerebellar Purkinje-cell degeneration. These results identify an association between oxidative damage to lipid membranes and the severity of Lyst-mutant phenotypes, revealing a new mechanism that contributes to pathophysiology involving LYST.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}208{"query": "Many life science discoveries would not have been possible without the microscope. For example: Cells are the tiny building blocks of living things. They couldnt be discovered until the microscope was invented. The discovery of cells led to the cell theory. This is one of the most important theories in life science. Bacteria are among the most numerous living things on the planet. They also cause many diseases. However, no one knew bacteria even existed until they could be seen with a microscope. The invention of the microscope allowed scientists to see cells, bacteria, and many other structures that are too small to be seen with the unaided eye. It gave them a direct view into the unseen world of the extremely tiny. You can get a glimpse of that world in Figure 1.10. The microscope was invented more than four centuries ago. In the late 1500s, two Dutch eyeglass makers, Zacharias Jansen and his father Hans, built the first microscope. They put several magnifying lenses in a tube. They discovered that using more than one lens magnified objects more than a single lens. Their simple microscope could make small objects appear nine times bigger than they really were. In the mid-1600s, the English scientist Robert Hooke was one of the first scientists to observe living things with a microscope. He published the first book of microscopic studies, called Micrographia. It includes wonderful drawings of microscopic organisms and other objects. One of Hookes most important discoveries came when he viewed thin slices of cork under a microscope. Cork is made from the bark of a tree. When Hooke viewed it under a microscope, he saw many tiny compartments that he called cells. He made the drawing in Figure 1.11 to show what he observed. Hooke was the first person to observe the cells from a once-living organism. In the late 1600s, Anton van Leeuwenhoek, a Dutch lens maker and scientist, started making much stronger microscopes. His microscopes could magnify objects as much as 270 times their actual size. Van Leeuwenhoek made many scientific discoveries using his microscopes. He was the first to see and describe bacteria. He observed them in a sample of plaque that he had scraped off his own teeth. He also saw yeast cells, human sperm cells, and the microscopic life teeming in a drop of pond water. He even saw blood cells circulating in tiny blood vessels called capillaries. The drawings in Figure 1.12 show some of tiny organisms and living cells that van Leeuwenhoek viewed with his microscopes. He called them animalcules. These early microscopes used lenses to refract light and create magnified images. This type of microscope is called a light microscope. Light microscopes continued to improve and are still used today. The microscope you might use in science class is a light microscope. The most powerful light microscopes now available can make objects look up to 2000 times their actual size. You can learn how to use a light microscope by watching this short video: http MEDIA Click image to the left or use the URL below. URL: To see what you might observe with a light microscope, watch the following video. It shows some amazing creatures in a drop of stagnant water from an old boat. What do you think the creatures might be? Do they look like any of van Leeuwenhoeks animalcules in Figure 1.12? MEDIA Click image to the left or use the URL below. URL: For an object to be visible with a light microscope, it cant be smaller than the wavelength of visible light (about 550 nanometers). To view smaller objects, a different type of microscope, such as an electron microscope, must be used. Electron microscopes pass beams of electrons through or across an object. They can make a very clear image that is up to 2 million times bigger than the actual object. An electron microscope was used to make the image of the ant head in Figure 1.10.", "pos": "Microscopes, tools that you may get to use in your class, are some of the most important tools in biology ( Figure Microscopy is the study of small objects using microscopes. Look at your fingertips. Before microscopes were invented in 1595, the smallest things you could see on yourself were the tiny lines in your skin. But what else is hidden in your skin? Over four hundred years ago, two Dutch spectacle makers, Zaccharias Janssen and his son Hans, were experimenting with several lenses in a tube. They discovered that nearby objects appeared greatly enlarged, or magnified. This was the forerunner of the compound microscope and of the telescope. In 1665, Robert Hooke, an English natural scientist, used a microscope to zoom in on a piece of cork - the stuff that makes up the stoppers in wine bottles, which is made from tree bark. Inside of cork, he discovered tiny structures, which he called cells. It turns out that cells are the smallest structural unit of living organisms. This finding eventually led to the development of the theory that all living things are made of cells. Without microscopes, this discovery would not have been possible, and the cell theory would not have been developed. Hookes discovery of the cell set the stage for other scientists to discover other types of organisms. After Hooke, the \"father of microscopy,\" Dutch scientist Antoine van Leeuwenhoek ( Figure 1.2) taught himself to make one of the first microscopes. In one of his early experiments, van Leeuwenhoek took a sample of scum from his own teeth and used his microscope to discover bacteria, the smallest living organism on the planet. Using microscopes, van Leeuwenhoek also discovered one-celled protists and sperm cells. Today, microscopes are used by all types of scientists, including cell biologists, microbiologists, virologists, forensic scientists, entomologists, taxonomists, and many other types. Antoine van Leeuwenhoek, a Dutch cloth merchant with a passion for microscopy. Some modern microscopes use light, as Hookes and van Leeuwenhoeks did. Others may use electron beams or sound waves. Researchers now use these four types of microscopes: 1. Light microscopes allow biologists to see small details of a specimen. Most of the microscopes used in schools and laboratories are light microscopes. Light microscopes use lenses, typically made of glass or plastic, to focus light either into the eye, a camera, or some other light detector. The most powerful light microscopes can make images up to 2,000 times larger. 2. Transmission electron microscopes (TEM) focus a beam of electrons through an object and can make an image up to two million times bigger, with a very clear image. 3. Scanning electron microscopes (SEM) allow scientists to find the shape and surface texture of extremely small objects, including a paperclip, a bedbug, or even an atom. These microscopes slide a beam of electrons across the surface of a specimen, producing detailed maps of the surface of objects. Magnification in a SEM can be controlled over a range from about 10 to 500,000 times. 4. Scanning acoustic microscopes use sound waves to scan a specimen. These microscopes are useful in biology and medical research. Scanning Electron Microscope at (5:04) Click image to the left or use the URL below. URL: 1. How is the electron beam focused? 2. What part of a specimen does a scanning electron microscope look at? 3. Why is it important that a specimen for an electron microscope be placed in a vacuum? Why is this step unnecessary for a light microscope?", "neg": "A cell is the smallest structural and functional unit of an organism. Some organisms, like bacteria, consist of only one cell. Big organisms, like humans, consist of trillions of cells. Compare a human to a banana. On the outside, they look very different, but if you look close enough youll see that their cells are actually very similar. Most cells are so small that you cannot see them without the help of a microscope. It was not until 1665 that English scientist Robert Hooke invented a basic light microscope and observed cells for the first time, by looking at a piece of cork. You may use light microscopes in the classroom. You can use a light microscope to see cells ( Figure 1.1). But many structures in the cell are too small to see with a light microscope. So, what do you do if you want to see the tiny structures inside of cells? In the 1950s, scientists developed more powerful microscopes. A light microscope sends a beam of light through a specimen, or the object you are studying. A more powerful microscope, called an electron microscope, passes a beam of electrons through the specimen. Sending electrons through a cell allows us to see its smallest parts, even the parts inside the cell ( Figure 1.2). Without electron microscopes, we would not know what the inside of a cell looked like. The outline of onion cells are visible under a light microscope. In 1858, after using microscopes much better than Hookes first microscope, Rudolf Virchow developed the hypoth- esis that cells only come from other cells. For example, bacteria, which are single-celled organisms, divide in half (after they grow some) to make new bacteria. In the same way, your body makes new cells by dividing the cells you already have. In all cases, cells only come from cells that have existed before. This idea led to the development of one of the most important theories in biology, the cell theory. Cell theory states that: 1. All organisms are composed of cells. 2. Cells are alive and the basic living units of organization in all organisms. 3. All cells come from other cells. As with other scientific theories, many hundreds, if not thousands, of experiments support the cell theory. Since Virchow created the theory, no evidence has ever been identified to contradict it. Although cells share many of the same features and structures, they also can be very different ( Figure 1.3). Each cell in your body is designed for a specific task. In other words, the cells function is partly based on the cells structure. For example: Red blood cells are shaped with a pocket that traps oxygen and brings it to other body cells. Nerve cells are long and stringy in order to form a line of communication with other nerve cells, like a wire. Because of this shape, they can quickly send signals, such as the feeling of touching a hot stove, to your brain. Skin cells are flat and fit tightly together to protect your body. As you can see, cells are shaped in ways that help them do their jobs. Multicellular (many-celled) organisms have many types of specialized cells in their bodies. Red blood cells (left) are specialized to carry oxygen in the blood. Neurons (cen- ter ) are shaped to conduct electrical im- pulses to many other nerve cells. These epidermal cells (right) make up the skin of plants. Note how the cells fit tightly together. While cells are the basic units of an organism, groups of cells can perform a job together. These cells are called specialized because they have a special job. Specialized cells can be organized into tissues. For example, your liver cells are organized into liver tissue. Your liver tissue is further organized into an organ, your liver. Organs are formed from two or more specialized tissues working together to perform a job. All organs, from your heart to your liver, are made up of an organized group of tissues. These organs are part of a larger system, the organ systems. For example, your brain works", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}209{"query": "Viroids are small, circular, single-stranded RNA molecules that cause several infectious plant diseases. Viroids do not encode any pathogen-specific peptides but nonetheless, the subviral pathogens replicate autonomously and spread in the plant by recruiting host proteins via functional motifs encoded in their RNA genome. During the past couple of years, considerable progress has been made towards comprehending how viroids interact with their hosts. Here, we summarize recent findings on the structure-function relationships of viroids, their strategies and mechanisms of replication and trafficking, and the identification and characterization of interacting host proteins. We also describe the impact of the RNA silencing machinery of plants on viroid RNAs and how this has started to influence our models of viroid replication and pathogenicity.", "pos": "Contrary to earlier beliefs, viruses are not the smallest causative agents of infectious diseases. Single-stranded RNAs as small as 246 nucleotides exist in certain higher plants and cause more than a dozen crop diseases. These RNAs have been termed viroids. Despite their extremely limited information content, viroids replicate autonomously in susceptible cells--that is, they do not require helper functions from simultaneously replicating conventional viruses. Viroids are covalently closed circular molecules with a characteristic rodlike secondary structure in which short helical regions are interrupted by internal and bulge loops. Viroids are not translated; they are replicated by a host enzyme (or enzymes) (probably RNA polymerase II) via oligomeric RNA intermediates by a rolling circle mechanism. Viroidlike satellite RNAs resemble viroids in size and molecular structure, but are found within the capsids of specific helper viruses on which they depend for their own replication. These RNAs are of great interest to molecular biology for at least two reasons: 1) they are the smallest and simplest replicating molecules known, and 2) they may represent living fossils of precellular evolution in a hypothetical RNA world.", "neg": "MicroRNAs (miRNAs) regulate many biological processes such as development, metabolism, and others. They are processed from their primary transcripts called primary miRNA transcripts (pri-miRNAs) by the processor complex containing the RNAse III enzyme, DICER-LIKE1 (DCL1), in plants. Consequently, miRNA biogenesis is controlled through altering pri-miRNA accumulation and processing, which is crucial for plant development and adaptation to environmental changes. Plant pri-miRNAs are transcribed by DNA-dependent RNA polymerase II (Pol II) and their levels are determined through transcription and degradation, whereas pri-miRNA processing is affected by its structure, splicing, alternative splicing, loading to the processor and the processor activity, which involve in many accessory proteins. Here, we summarize recent progresses related to pri-miRNA transcription, stability, and processing in plants.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}210{"query": "Elizabeth Potts (nee Atherton; December 21, 1846 -- June 20, 1890) was convicted of murder in 1889 and hanged the following year, the only woman ever to be legally executed in the U.S. state of Nevada.", "pos": "Elizabeth Jeffries (1727, Bridgnorth, Shropshire -- March 28, 1752 in Leytonstone, England) was an English woman executed for murder.", "neg": "Following the assassination of her nephew Ptolemy XI Alexander II (80 BC), Cleopatra Selene I remained the only legitimate surviving member of the Ptolemaic dynasty.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}211{"query": "The Broadgate Tower was designed by Skidmore, Owings & Merrill and developed by British Land.", "pos": "Riparian Plaza was designed by Harry Seidler (architect) and Robert Bird Group (structural engineer).", "neg": "The Duke's Cut was completed by the Duke of Marlborough in 1789 to link the new canal with the River Thames; and, in 1796, the Oxford Canal company built its own link to the Thames, at Isis Lock.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}212{"query": "Corynebacterium minutissimum is the bacteria that leads to cutaneous eruptions of erythrasma and is the most common cause of interdigital foot infections. It is found mostly in occluded intertriginous areas such as the axillae, inframammary areas, interspaces of the toes, intergluteal and crural folds, and is more common in individuals with diabetes mellitus than other clinical patients. This organism can be isolated from a cutaneous site along with a concurrent dermatophyte or Candida albicans infection. The differential diagnosis of erythrasma includes psoriasis, dermatophytosis, candidiasis and intertrigo, and methods for differentiating include Wood's light examination and bacterial and mycological cultures. Erythromycin 250mg four times daily for 14 days is the treatment of choice and other antibacterials include tetracycline and chloramphenicol; however, the use of chloramphenicol is limited by bone marrow suppression potentially leading to neutropenia, agranulocytosis and aplastic anaemia. Further studies are needed but clarithromycin may be an additional drug for use in the future. Where there is therapeutic failure or intertriginous involvement, topical solutions such as clindamycin, Whitfield's ointment, sodium fusidate ointment and antibacterial soaps may be required for both treatment and prophylaxis. Limited studies on the efficacy of these medications exist, however, systemic erythromycin demonstrates cure rates as high as 100%. Compared with tetracyclines, systemic erythromycin has greater efficacy in patients with involvement of the axillae and groin, and similar efficacy for interdigital infections. Whitfield's ointment has equal efficacy to systemic erythromycin in the axillae and groin, but shows greater efficacy in the interdigital areas and is comparable with 2% sodium fusidate ointment for treatment of all areas. Adverse drug effects and potential drug interactions need to be considered. No cost-effectiveness data are available but there are limited data on cost-related treatment issues. A guideline is proposed for the detection, evaluation, treatment and prophylaxis of this cutaneous eruption.", "pos": "Erythrasma is a skin infection which is caused by Corynebacterium minutissimum. Interdigital erythrasma is the most common form. The aim of this study was to detect the frequency and risk factors of interdigital erythrasma in patients with clinically suspected tinea pedis. This study was conducted between June and December 2010 and included 122 patients who had interdigital foot lesions. All patients were examined using a Wood's lamp. The smears were stained using Gram's method. Direct examination was performed using 20% potassium hydroxide. Sabouraud dextrose agar and brain heart infusion agar were used for cultures. Moreover, the demographical characteristics of patients, concomitant diseases and clinical findings were also recorded. Cases that were found to be positive on Wood's lamp examination and/or Gram staining/culture were considered as erythrasma. The rate of erythrasma was found to be 46.7%. The mean age was 43.6 years, and the disease was more prevalent in men. The most common clinical finding was desquamation. Mycological examination was found as positive in 40.35% of the patients. No growth was observed in bacteriological cultures. It was found that using only Wood's lamp examination or Gram staining resulted in 11 (9%) and 19 positive patients (15.6%), respectively, whereas using both Wood's lamp examination and Gram staining concurrently resulted in 27 positive patients (22.1%). Interdigital erythrasma is a commonly seen condition and can clinically mimic tinea pedis. A Wood's lamp is a good diagnostic tool, but Gram staining, particularly in those with a negative Wood's lamp result, may be a useful method.", "neg": "With the recent introduction of inhibitors of mammalian target of rapamycin (mTOR) in oncology, distinct cutaneous and oral adverse events have been identified. In fact, stomatitis and rash are documented as the most frequent and potentially dose-limiting side effects. Clinically, mTOR inhibitor-associated stomatitis (mIAS) more closely resembles aphthous stomatitis than oral mucositis due to conventional anticancer therapies. While most cases of mIAS are mild to moderate and self-limiting, more severe and persistent mIAS can become a dose-limiting toxicity. Small ulcerations may cause significant pain and mucosal sensitivity may occur in the absence of clinical changes. Use of clinical assessment tools that are primarily driven by ulceration size may underestimate mIAS, and assessment should include patient-reported outcomes. This article provides an up-to-date review of the clinical presentation, terminology, pathogenesis, assessment and management of mIAS and other mTOR inhibitor-associated oral adverse events. In addition, areas of future research are considered.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}213{"query": "Travis Graham (born 8 May 1993) is a South African football player who plays as a midfielder for Ajax Cape Town in the Premier Soccer League.", "pos": "Mamadou Sidibe is a Malian professional footballer, who plays as a midfielder for AS Police de Bamako.", "neg": "Jefte Betancor Sanchez (born 6 July 1993) is a Spanish footballer who plays for UD Las Palmas Atletico as a forward.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}214{"query": "When Serbia and Montenegro peacefully separated in 2006, the YUBA League ceased to exist and was re-branded as the Basketball League of Serbia a Serbia-only organization, with Montenegro forming its own federation.", "pos": "On 24 July 1867, a part of the territory of Bagnolet was detached and merged with a part of the territory of Romainville and a part of the territory of Pantin to create the commune of Les Lilas.", "neg": "Jean-Pierre Vande Velde (born 10 September 1955 in Belgium) is a former Belgian footballer, currently managing Temse in the Belgian Third Division after being fired from Union SG.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}215{"query": "Harvey Shine (Dustin Hoffman) works as a jingle writer for television commercials in Manhattan, a job not in keeping with his one-time aspiration to be a jazz composer and pianist. We see him at work and he is very good at what he does. However, his boss does not seem impressed with his latest output. As Harvey departs for London to attend his daughter Susan's wedding, his boss actually suggests that he spend more time there than he had originally planned. Harvey declines, making the point that he needs to be back for an upcoming pitch to an old client. His boss insists that it is being done by other musicians, and that Harvey's latest work was his last chance to keep his job.On the plane, Harvey tries to chat up a fellow passenger, but she is having none of it. He is left sitting there with egg on his face and we come to regard him as even more of a loser.Meanwhile, we witness the mildly strained relationship between Kate Walker (Emma Thompson), a single Londoner, and her mother, whose husband left years earlier. Kate tries to reassure her mother that despite being single, she may yet find a man. Further, Kate tells her mom to quit worrying about the new Polish neighbor who has moved in next door and seems to be stacking a lot of firewood.Upon arrival at Heathrow Airport in London, Harvey encounters Kate at her job collecting statistics from passengers as they pass through the terminals. She attempts to question him about his reasons for visiting the UK. Tired and anxious to get to his hotel, Harvey brusquely dismisses her when she approaches him to ask questions.Harvey heads for the hotel to check in and discovers that he is the first one to arrive. Upon calling his daughter to double check where everyone else is when they were all supposed to be staying together, he learns that his ex-wife Jean actually rented a house to accommodate family and friends from the States and he is the only one at the hotel.After a brief nap, he showers and hurriedly dresses. On the way to the rehearsal dinner in the taxi cab, he realizes the anti-shoplifting device is still attached to the sleeve of his jacket. And to make matter worse, he has worn a white suit (thinking this was requested) while all the other men wore black. During the meal, it becomes increasingly clear Harvey is considered a mere guest and the role of father of the bride has been delegated to Jean's husband Brian. To add insult to injury, Brian stands to give the toast, and recollects the vacation they all spent in Rome, and his stepson-in-law-to-be embraces him and calls him Dad. Just before leaving back to his hotel, when Harvey tells Susan (with whom he has shared a strained relationship since his divorce) that he will be attending the ceremony but not the subsequent reception because he needs to return to the States for an important meeting, she informs him she has asked Brian to give her away.Meanwhile, Kate is set up on a blind date by a well meaning co-worker that does not go well. When she returns to the table after taking yet another call from her mother, she discovers her younger date has invited some of his younger friends to join them. Feeling unwanted and excluded from the conversation, she eventually excuses herself and goes home. As it turns out, Kate's increasingly neurotic mother seems convinced that her Polish neighbor is some kind of murderer because she sees him toting strange looking, lumpy packages into a shed in the back yard.The following morning Harvey attends Susan's wedding, but heavy traffic delays his arrival back to Heathrow, and he misses his plane. When he calls his boss Marvin in NYC to inform him he will be returning a day later than planned and that he will try to get there as soon as possible, he is told that he is fired.In his glum mood, Harvey makes his way to the airport bar and starts slugging down scotch, determined to drown his sorrows. Kate is sitting in the lounge reading", "pos": "Set on the campus of a small New England college, the film focuses on the volatile relationship of a middle-aged couple: associate history professor George (Richard Burton) and his hard-drinking wife Martha (Elizabeth Taylor), the daughter of the college president.It's 2:00 a.m. on a Sunday morning, and they have returned from one of her father's gatherings. Martha announces she has invited a young couple--Nick (George Segal), a young, good-looking, newly appointed instructor, and his mousey wife Honey (Sandy Dennis)--to join them for late-night drinks. George is disturbed because she did so without consulting him first, prompting Martha to launch into the first of many loud and lengthy tirades during which she taunts and criticizes him. Knowing his wife is drunk and quite lewd, he asks her to behave herself when they arrive, and when the doorbell rings, he warns her to refrain from mentioning their child to their company.Overhearing Martha's crude retort as the door opens, Nick and Honey immediately feel ill at ease and quickly find themselves caught in the middle of a verbal war zone when their efforts to engage in small talk set off a volley of insults between their hosts. Martha begins to flirt lewdly with Nick while his meek wife tries to pretend she is unaware of what is happening.While Martha is showing Honey where the bathroom is, George tests Nick's verbal sparring skills, but the young man is no match for his host. Realizing he and his wife are becoming embroiled in the middle of marital warfare, he suggests they depart, but George cajoles him into staying.Upon returning to the living room alone, Honey innocently mentions to George she was unaware he and Martha had a son on the verge of celebrating his 16th birthday. Martha reappears in a new outfit--form-fitting slacks and a revealing blouse--and when her husband makes a snide remark about the ensemble, she begins to demean his abilities as a teacher, then escalates her seduction of Nick, complimenting him on the body he developed as both a quarterback and an intercollegiate state boxing champion while criticizing George's paunch. She informs their guests about a past incident when George refused to engage in a friendly outdoor boxing match with his father-in-law and Martha put on a pair of gloves and punched him in the jaw, knocking him into the bushes. As she relates the story, George aims a shotgun at the back of her head, causing Honey to scream. He pulls the trigger, which releases an umbrella, while he tells his wife she's dead.Honey again raises the subject of George and Martha's son, prompting the couple to engage in a conversation Martha quickly tries to end without success. To counterattack George's relentless comments about the boy, she tells their guests her husband is unsure the child is his own, although he most assuredly is. They argue about the color of the boy's eyes until George threatens to expose the truth about the boy. Furious, Martha accuses him of being a failure whose youthful, idealistic plans for the future slowly deteriorated as he came to realize he wasn't aggressive enough to follow in his father-in-law's footsteps, leaving her stuck with a flop. George cuts the diatribe short by spinning Honey around and mockingly singing, \"Who's afraid of Virginia Woolf?\", a joke the shrewed Martha had made herself during the party earlier that evening.Inebriated and on the verge of throwing up from George's spinning, Honey rushes from the room. Martha goes to the kitchen to make coffee, and George and Nick go outside. The younger man confesses he was attracted to Honey more for her family's money than passion, and married her only because she mistakenly believed she was pregnant. George describes his own marriage as one of never-ending accommodation and adjustment, then admits he considers Nick a threat. George also tells a story about a boy he grew up with. This boy had accidentally killed his mother. Years later, George claims the boy was driving with his father. He swerved to \"miss a porcupine\" in the road,", "neg": "Marigold Lexton (Ali Larter), a self-centered and temperamental young American actress, arrives in India expecting to be treated like a star, despite the fact that she has been making nothing but B movie sequels for some time. She is stranded in Goa after the film she was to star in is canceled, and a sympathetic crew member offers her a ride, which brings her to the set of another movie, a Bollywood musical. She actually tells her boyfriend Barry that she was hoping she wouldn't have to marry him if this trip was successful, and soon finds herself the center of attraction on the set, where she quickly lands a minor role and a date with the spoiled young lead actor. But after she rebuffs his crude proposal that night she winds up talking with Prem (Salman Khan), the film's choreographer. He knows she lied about being able to dance, and takes her in hand, while showing her the nearby towns and countryside in their spare time. As they grow closer Prem talks to her about the importance of family, and she not only learns that he is estranged from his father, but that he is also a prince. He had not seen his family in three years, but the day before he received a call from his sister, asking him to come home for her wedding. He asks Marigold to go home with him to Jodhpur, Rajasthan, for the wedding, since shooting on the movie had been shut down for a week. She is entranced by the generosity and opulence of his family leading up to the wedding, but afterwards is shocked to discover that he has been betrothed to another since childhood. He has fallen totally in love with Marigold, but has neglected to mention the long arranged marriage, and his father has not encouraged him to follow his heart. She feels betrayed and storms out, followed by Prem's fiance, who offers to buy her a drink. She confesses to Marigold that although she loves Prem she doesn't believe he has ever really loved her. Meanwhile, Prem, a teetotaler, heads to a bar to drown his sorrows, where he finds a drunken American who commiserates with his romantic problems. He explains he has come looking for his estranged girlfiend, called Marigold, and Prem invites him to stay the night at his parents' house. Barry accepts and then passes out. In the morning, Marigold decides to return with Barry to the United States, since Prem, the only son of Jaipur's Ruler, feels duty bound to marry the woman his father has chosen. The ceremony takes place that day, and as he follows his bride, whose face is totally hidden behind a long veil, seven times around the Holy fire, Prem believes he is marrying the woman he has been engaged to since childhood. With the marriage complete, Prem lifts his wife's veil, and he and most of the guests are astonished to find Marigold standing before himand it appears that Barry has married Prem's former fiance as well. The movie's director and their friends from the crew appear in the crowd, cheering, then Prem sings and dances with Marigold and a full chorus, just like a happy ending in a Bollywood musical.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}216{"query": "It's eight o'clock and the time for Morning New Highlights . One person was killed and two were injured in a car accident just thirty minutes ago. Cause of the accident is not yet found out. A great fire swept through a storehouse next to the Fulton River early this morning, causing about $3,000,000 in damage. The fire which broke out at about 2:30 was finally put out at 5: 30. That was the Morning News Highlights, Dan Verne reporting.", "pos": "April 11, 2003 12:44 a. m. PST, Associated Press The respiratory virus known as SARS has appeared to spread in the United States only to family members of health workers with close contact to a sick person. On Thursday, the head of the Centers for Disease Control and Prevention said there might be a case of severe acute respiratory syndrome spreading through the workplace. Dr. Julie Gerberding said a suspected SARS virus patient who became ill after traveling to Asia might have infected a co-worker in Florida, which made her \"very worried\". So far, a dozen people--nine family members and three health workers--were infected after coming into close contact with the person with SARS. The rest of the 166 suspected American cases have something to do with people who were infected while traveling in Asia. In the Gainesville, Fla. area, a 47-year-old woman was believed to have been infected at work by a 60-year-old woman who was the nation's first suspected SARS case, said Tom Belcuore, director of the Alachua County health department. Since the World Health Organization announced a worldwide warning last month about SARS, the United States has started infection control in hospitals and among families of suspected cases. Florida officials said a school in Okaloosa County went through a cleaning after a 6-year-old boy suspected of having SARS appeared at school with slight symptoms. \"Health officials are watching the boys' contacts at school to make sure no one else is infected,\" said Rob Hayes, health department spokesman, \"The boy may have been infected from a family member,\" Hayes said, \"We immediately became aware of it and had the child sent home. He's staying at home with his family until 10 days after symptoms disappear.\" The researchers guessed that the virus might have come from animals. However, the scientists have not ruled out the possibility that some other microbe might also help make SARS more serious or easier to catch.", "neg": "On July 7, 1981, while being driven from the Chicago area to a speaking engagement near Knox, Indiana, Peace Pilgrim was killed in an automobile accident.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}217{"query": "The 2010 maternal mortality rate per 100,000 births for Guinea is 680. This is compared with 859.9 in 2008 and 964.7 in 1990. The under 5 mortality rate, per 1,000 births is 146 and the neonatal mortality as a percentage of under 5s mortality is 29. In Guinea the number of midwives per 1,000 live births is 1 and the lifetime risk of death for pregnant women is 1 in 26. Guinea has the second highest prevalence of female genital mutilation in the world.", "pos": "A single soldier arriving in Mexico in 1520 was carrying smallpox and thus initiated the devastating plagues that swept through the native populations of the Americas. The European diseases that ravaged the indigenous inhabitants of the Americas also severely affected the various Maya groups of Peten. It is estimated that there were approximately 30,000 Ch'ol and Ch'olti' Maya in western Peten at the start of the 16th century. Between 1559 and 1721 they were devastated by a combination of disease, war and enforced relocations. When Nojpeten fell in 1696 there were approximately 60,000 Maya living around Lake Peten Itza, including a considerable number of refugees from other areas. It is estimated that 88% of the inhabitants died during the first decade of colonial rule because of disease and war. Although disease was responsible for the majority of deaths, internecine warfare between rival Maya groups and Spanish expeditions also took their toll.", "neg": "Malaria remains one of the few diseases those continue to scourge human civilization despite the significant advances in disease control strategies over the last century. Malaria is responsible for more than 500 million cases and 1-3 million deaths annually. Approximately 85% of these deaths are among children, mostly in Africa, primarily due to P. falciparum. Whole cell vaccines, irradiated sporozoites and genetically attenuated sporozoites have demonstrated long lasting, sterile protection against plasmodium infection in animal and experimental clinical studies. Atypical membrane protein 1 and merozoite surface protein 1 are the two most extensively studied asexual blood stage vaccine candidates. The most promising candidate vaccine under development is RTS, S combined with AS01 adjuvant. Initial results from phase III trials of this candidate vaccine show 50% reduction of malaria in 5-17 mo aged children during the 12 mo after vaccination. WHO anticipates that the RTS,S/AS01 vaccine will be recommended for the 6-14 week age group for co-administration together with other vaccines as part of routine immunization programs in malaria endemic countries. Malaria vaccine could play an important role in elimination and eventual eradication of malaria.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}218{"query": "With transform plate boundaries, the two slabs of lithosphere are sliding past each other in opposite directions. The boundary between the two plates is a transform fault. Transform faults on continents separate two massive plates of lithosphere. As they slide past each other, they may have massive earthquakes. The San Andreas Fault in California is perhaps the worlds most famous transform fault. Land on the west side is moving northward relative to land on the east side. This means that Los Angeles is moving northward relative to Palm Springs. The San Andreas Fault is famous because it is the site of many earthquakes, large and small. (Figure At the San Andreas Fault in California, the Pacific Plate is sliding northeast relative to the North American plate, which is moving southwest. At the northern end of the picture, the transform boundary turns into a subduction zone. Transform plate boundaries are also found in the oceans. They divide mid-ocean ridges into segments. In the diagram of western North America, the mid-ocean ridge up at the top, labeled the Juan de Fuca Ridge, is broken apart by a transform fault in the oceans. A careful look will show that different plates are found on each side of the ridge: the Juan de Fuca plate on the east side and the Pacific Plate on the west side.", "pos": "Almost all earthquakes occur at plate boundaries. All types of plate boundaries have earthquakes. Convection within the Earth causes the plates to move. As the plates move, stresses build. When the stresses build too much, the rocks break. The break releases the energy that was stored in the rocks. The sudden release of energy creates an earthquake. During an earthquake the rocks usually move several centimeters or rarely as much as a few meters. Elastic rebound theory describes how earthquakes occur (Figure 7.21). Where an earthquake takes place is described by its focus and epicenter. The point where the rock ruptures is the earthquakes focus. The focus is below the Earths surface. A shallow earthquake has a focus less than 70 kilometers (45 miles). An intermediate-focus earthquake has a focus between 70 and 300 kilometers (45 to 200 miles). A deep-focus earthquake is greater than 300 kilometers (200 miles). About 75% of earthquakes have a focus in the top 10 to 15 kilometers (6 to 9 miles) of the crust. Shallow earthquakes cause the most damage. This is because the focus is near the Earths surface, where people live. The area just above the focus, on the land surface, is the earthquakes epicenter (Figure 7.22). The towns or cities near the epicenter will be strongly affected by the earthquake. Nearly 95% of all earthquakes take place along one of the three types of plate boundaries. As you learned in the Plate Tectonics chapter, scientists use the location of earthquakes to draw plate boundaries. The region around the Pacific Ocean is called the Pacific Ring of Fire. This is due to the volcanoes that line the region. The area also has the most earthquakes. About 80% of all earthquakes strike this area. The Pacific Ring of Fire is caused by the convergent and transform plate boundaries that line the Pacific Ocean basin. About 15% of all earthquakes take place in the Mediterranean-Asiatic belt. The convergent plate boundaries in the region are shrinking the Mediterranean Sea. The convergence is also causing the Himalayas to grow. The remaining 5% of earthquakes are scattered around the other plate boundaries. A few earthquakes take place in the middle of a plate, away from plate boundaries. Transform plate boundaries produce enormous and deadly earthquakes. These quakes at transform faults have shallow focus. This is because the plates slide past each other without moving up or down. The largest earthquake on the San Andreas Fault occurred in 1906 in San Francisco. Other significant earthquakes in California include the 1989 Loma Prieta earthquake near Santa Cruz (Figure 7.23) and the 1994 Northridge earthquake near Los Angeles. There are many other faults spreading off the San Andreas, which produce around 10,000 earthquakes a year (Figure Convergent plate boundaries also produce strong, deadly earthquakes. Earthquakes mark the motions of colliding plates and the locations where plates plunge into the mantle. These earthquakes can be shallow, intermediate or deep focus. The Philippine plate and the Pacific plate subduct beneath Japan, creating as many as 1,500 earthquakes every year. In March 2011, the 9.0 magnitude Tohoku earthquake struck off of northeastern Japan. Damage from the quake was severe. More severe was the damage from the tsunami generated by the quake (Figure 7.25). In all, 25,000 people were known dead or missing. The Cascades Volcanoes line the Pacific Northwest of the United States. Here, the Juan de Fuca plate subducts beneath the North American plate. The Cascades volcanoes are active and include Mount Saint Helens. Major earthquakes occur here approximately every 300 to 600 years. The last was in 1700. Its magnitude was between 8.7 and 9.2. It has now been more than 300 years since that earthquake. The next massive earthquake could strike the Pacific Northwest at any time. The collision of two continents also creates massive earthquakes. Many earthquakes happen in the region in and around the Himalayan Mountains. The 2001 Gujarat, India earthquake is responsible for about 20,000 deaths, with many more people injured or made homeless. Earthquakes also occur at divergent plate boundaries. At mid-ocean ridges, these earthquakes tend to be small and shallow focus because the", "neg": "First, lets review plate tectonics theory. Plate tectonics theory explains why: Earths geography has changed over time and continues to change today. some places are prone to earthquakes while others are not. certain regions may have deadly, mild, or no volcanic eruptions. mountain ranges are located where they are. many ore deposits are located where they are. living and fossil species are found where they are. Plate tectonic motions affect Earths rock cycle, climate, and the evolution of life. Remember that Wegener used the similarity of the mountains on the west and east sides of the Atlantic as evidence for his continental drift hypothesis. Those mountains rose at the convergent plate boundaries where the continents were smashing together to create Pangaea. As Pangaea came together about 300 million years ago, the continents were separated by an ocean where the Atlantic is now. The proto-Atlantic ocean shrank as the Pacific Ocean grew. The Appalachian mountains of eastern North America formed at a convergent plate boundary as Pangaea came together (Figure 1.1). About 200 million years ago, the they were probably as high as the Himalayas, but they have been weathered and eroded significantly since the breakup of Pangaea. Pangaea has been breaking apart since about 250 million years ago. Divergent plate boundaries formed within the continents to cause them to rift apart. The continents are still moving apart, since the Pacific is shrinking as the Atlantic is growing. If the continents continue in their current directions, they will come together to create a supercontinent on the other side of the planet in around 200 million years. If you go back before Pangaea there were earlier supercontinents, such as Rodinia, which existed 750 million to 1.1 billion years ago, and Columbia, at 1.5 to 1.8 billion years ago. This supercontinent cycle is responsible for most of the geologic features that we see and many more that are long gone (Figure 1.2). Scientists think that the creation and breakup of a supercontinent takes place about every 500 million years. The supercontinent before Pangaea was Rodinia. A new continent will form as the Pacific ocean disappears. Click image to the left or use the URL below. URL:", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}219{"query": "In late 1911, she worked as a secretary for Sun Yat-sen, a job later succeeded by her sister, Soong Ching-ling, who later became Madame Sun Yat-sen. Soong Ai-ling met her future husband, Kung Hsiang Hsi, in 1913, and married the following year in Yokohama.", "pos": "Athole Shearer (November 20, 1900 -- March 17, 1985) was an actress most noted as the sister of motion picture star Norma Shearer and film sound engineer Douglas Shearer.", "neg": "Min and Bill is a 1930 American Pre-Code comedy-drama film starring Marie Dressler and Wallace Beery and based on Lorna Moon's novel Dark Star, adapted by Frances Marion and Marion Jackson.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}220{"query": "at Invesco Field at Mile High, Denver, Colorado TV Time: ESPN 8:30pm eastern The Ravens suffered their first loss of the season as they were beaten 13-3 by the Denver Broncos. In a defensive struggle most of the game, Steve McNair was intercepted three times and Jamal Lewis was held to 43 yards rushing. The Ravens got on the board first when Matt Stover kicked a 24-yard field goal, following a fumble by Broncos RB Tatum Bell. The Broncos responded with a 43-yard field goal of their own by Jason Elam. The Ravens drove deep into Broncos territory late at the end of the first half, but that drive was thwarted as Steve McNair was intercepted by Champ Bailey in the end zone on a pass intended for Clarence Moore. The third quarter saw no points scored by either team as the defensive struggle continued. The Broncos controlled the clock in the second half with the running game led by Tatum Bell, who atoned for his fumble in the first quarter, by bouncing back with 92 yards rushing. Ravens QB McNair was intercepted again by Darrent Williams, which led to a Jake Plummer to Rod Smith touchdown pass. McNair was intercepted a third time, ending the Ravens' final drive, this time by Domonique Foxworth. With their first loss, the Ravens dropped to 4-1.", "pos": "Following their victory over the Patriots, the Steelers remained at home the next week for their second match-up of the season against division rivals the Baltimore Ravens. The Ravens scored first with an 18-yard field goal by kicker Billy Cundiff, the only points scored in the first quarter by either team. Steelers kicker Shaun Suisham answered with a 36-yard field goal early in the second quarter, and a 30-yard field goal near the end, but both of these were quickly matched by Baltimore's Cundiff with a 43-yard and 51-yard field goal, respectively, giving Baltimore a 9-6 lead at halftime. The Ravens then increased their lead in the third quarter when Ray Rice scored the first touchdown of the game on a 4-yard run. The Steelers rallied hard in the fourth quarter, with running back Rashard Mendenhall making a 1-yard run to score a touchdown, and then taking the lead for the first time in the game when quarterback Ben Roethlisberger made a successful 25-yard pass to wide receiver Mike Wallace in the endzone for a second touchdown. On their final drive of the game, the Steelers were ready to potentially increase their lead with a 47-yard field goal kick by Shaun Suisham, but a 5-yard delay of game penalty put them out of field goal range and they were instead forced to punt the ball to the Ravens. The Ravens then began a 92-yard drive, culminating in a 26-yard touchdown pass by quarterback Joe Flacco to wide receiver Torrey Smith in the endzone with just 8 seconds remaining, giving them the game.", "neg": "The Steelers stayed home for a 3-game home stand and for a Sunday Night duel against the Ravens. The Ravens scored first when Joe Flacco hooked up with Torrey Smith 35-yard TD pass to take a 7-0 lead for the only score of the first quarter. In the 2nd quarter, the Steelers managed to tie the game up when Ben Roethlisberger found Le'Veon Bell on a 5-yard TD pass for a 7-7 game. They eventually took the lead when Roethlisberger found Martavis Bryant on a 19-yard TD pass to make it a 14-7 game. The Ravens came within 4 as Justin Tucker kicked a 46-yard field goal to make it 14-10 game. However, the Steelers would manage to go ahead by 12 before halftime when Roethlisberger found Markus Wheaton on a 47-yard TD pass followed by a successful 2-point conversion for a 22-10 lead at halftime. After a scoreless 3rd quarter, the Steelers came out strong and went back to work in the 4th when Roethlisberger found Antonio Brown on a 54-yard TD pass making the score 29-10. The Ravens responded with a big play as Jacoby Jones ran a 108-yard kickoff return for a TD to make it a 29-17 game. Roethlisberger found Bryant again on an 18-yard TD pass to make the score 36-17. This was followed by the Ravens trying their hand at coming back when Flacco found Crockett Gillmore on a 1-yard TD pass (with a failed 2-point conversion) for a 36-23 score. But the Steelers were able to seal the game when Roethlisberger found Matt Spaeth on a 33-yard TD pass for a final score of 43-23. A week after passing for a franchise-record six touchdowns against Indianapolis, Roethlisberger duplicated the feat to lead Pittsburgh to its third consecutive win. The 12 touchdown passes over the last two games broke the NFL record of 11 set by Tom Flores for Oakland in the AFL in 1963 and matched by New England's Tom Brady in 2007.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}221{"query": "Hoping to break their current losing streak the Cardinals flew to Arrowhead Stadium for an interconference duel with the Chiefs. The Cardinals scored with kicker Jay Feely hitting a 36-yard field goal, but they fell behind with QB Matt Cassel completing a 1-yard TD pass to WR Dwayne Bowe. This was followed by RB Thomas Jones getting a 1 and a 3-yard TD run. The Cardinals responded with Feely making a 29-yard field goal, but they struggled further with kicker Ryan Succop getting a 23-yard field goal, followed by Cassel throwing a 38-yard TD pass to Bowe. The Cardinals cut the lead with QB Derek Anderson completing a 3-yard TD pass to WR Larry Fitzgerald.", "pos": "Coming off their bye week, the Jets stayed at home for a Week 10 duel with the Jacksonville Jaguars. New York would trail early in the first quarter with running back Maurice Jones-Drew's 33-yard touchdown run. The Jets would respond with kicker Jay Feely getting a 32-yard field goal, followed by rookie quarterback Mark Sanchez completing a 7-yard touchdown pass to wide receiver Jerricho Cotchery. In the second quarter, Jacksonville would take the lead as quarterback David Garrard got an 11-yard touchdown run and completed a 26-yard touchdown pass to wide receiver Mike Sims-Walker. New York would close out the half as Feely made a 37-yard field goal. After a scoreless third quarter, the Jets would regain the lead in the fourth quarter with a 40-yard field goal from Feely and a 1-yard touchdown run from running back Thomas Jones (with a failed 2-point conversion). However, the Jaguars got the last laugh as kicker Josh Scobee booted the game-winning 21-yard field goal.", "neg": "The Chiefs took an early lead on a 30-yard pass from Tyler Thigpen to Mark Bradley. The Chiefs defense continued to show improvement in the red zone, limiting the Chargers to two field goals instead of two touch downs. At the end of the first half, Thigpen threw a pass to 34yard touchdown pass to Tony Gonzalez. However, the extra point snap was botched and an attempt at a quick pass failed. The Chargers controlled the second half better than the first, scoring two touchdowns and leading the Chiefs by 7 at the end of the fourth quarter. The Chiefs' final drive ended with a 3-yard touchdown pass to Gonzalez. A 1-point PAT would tie the game. However, Herm Edwards told Thigpen to go for two, explaining in a post-game interview that the defense was too beat up for overtime play. The resulting two-point conversion ended in an incomplete pass. The Chiefs lost by one point.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}222{"query": "Specific reversal agents for non-vitamin K antagonist oral anticoagulants are lacking. Idarucizumab, an antibody fragment, was developed to reverse the anticoagulant effects of dabigatran. We undertook this prospective cohort study to determine the safety of 5 g of intravenous idarucizumab and its capacity to reverse the anticoagulant effects of dabigatran in patients who had serious bleeding (group A) or required an urgent procedure (group B). The primary end point was the maximum percentage reversal of the anticoagulant effect of dabigatran within 4 hours after the administration of idarucizumab, on the basis of the determination at a central laboratory of the dilute thrombin time or ecarin clotting time. A key secondary end point was the restoration of hemostasis. This interim analysis included 90 patients who received idarucizumab (51 patients in group A and 39 in group B). Among 68 patients with an elevated dilute thrombin time and 81 with an elevated ecarin clotting time at baseline, the median maximum percentage reversal was 100% (95% confidence interval, 100 to 100). Idarucizumab normalized the test results in 88 to 98% of the patients, an effect that was evident within minutes. Concentrations of unbound dabigatran remained below 20 ng per milliliter at 24 hours in 79% of the patients. Among 35 patients in group A who could be assessed, hemostasis, as determined by local investigators, was restored at a median of 11.4 hours. Among 36 patients in group B who underwent a procedure, normal intraoperative hemostasis was reported in 33, and mildly or moderately abnormal hemostasis was reported in 2 patients and 1 patient, respectively. One thrombotic event occurred within 72 hours after idarucizumab administration in a patient in whom anticoagulants had not been reinitiated. Idarucizumab completely reversed the anticoagulant effect of dabigatran within minutes. (Funded by Boehringer Ingelheim; RE-VERSE AD ClinicalTrials.gov number, NCT02104947.).", "pos": "The direct thrombin inhibitor dabigatran and the anti-Xa agents rivaroxaban, edoxaban, and apixaban are a new generation of oral anticoagulants. Their advantage over the vitamin K antagonists is the lack of the need for monitoring and dose adjustment. Their main disadvantage is currently the absence of a specific reversal agent. Dabigatran's, unlike the anti-Xa agents, absorption can be reduced by activated charcoal if administered shortly after ingestion and it can be removed from the blood with hemodialysis. Prothrombin complex concentrate, activated prothrombin complex concentrate, and recombinant factor VIIa all show some activity in reversing the anticoagulant effect of these drugs but this is based on ex vivo, animal, and volunteer studies. It is unclear, which, if any, of these drugs is the most suitable for emergency reversal. Three novel molecules (idarucizumab, andexanet, and PER977) may provide the most effective and safest way of reversal. These agents are currently in premarketing studies.", "neg": "ESSENTIALS: When high probability of pulmonary embolism (PE), sensitivity of computed tomography (CT) is unclear. We investigated the sensitivity of multidetector CT among 134 patients with a high probability of PE. A normal CT alone may not safely exclude PE in patients with a high clinical pretest probability. In patients with no clear alternative diagnosis after CTPA, further testing should be strongly considered. Whether patients with a negative multidetector computed tomographic pulmonary angiography (CTPA) result and a high clinical pretest probability of pulmonary embolism (PE) should be further investigated is controversial. This was a prospective investigation of the sensitivity of multidetector CTPA among patients with a priori clinical assessment of a high probability of PE according to the Wells criteria. Among patients with a negative CTPA result, the diagnosis of PE required at least one of the following conditions: ventilation/perfusion lung scan showing a high probability of PE in a patient with no history of PE, abnormal findings on venous ultrasonography in a patient without previous deep vein thrombosis at that site, or the occurrence of venous thromboembolism (VTE) in a 3-month follow-up period after anticoagulation was withheld because of a negative multidetector CTPA result. We identified 498 patients with a priori clinical assessment of a high probability of PE and a completed CTPA study. CTPA excluded PE in 134 patients; in these patients, the pooled incidence of VTE was 5.2% (seven of 134 patients; 95% confidence interval [CI] 1.5-9.0). Five patients had VTEs that were confirmed by an additional imaging test despite a negative CTPA result (five of 48 patients; 10.4%; 95% CI 1.8-19.1), and two patients had objectively confirmed VTEs that occurred during clinical follow-up of at least 3 months (two of 86 patients; 2.3%; 95% CI 0-5.5). None of the patients had a fatal PE during follow-up. A normal multidetector CTPA result alone may not safely exclude PE in patients with a high clinical pretest probability.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}223{"query": "Peregrine Bertie, 13th Baron Willoughby de Eresby (12 October 1555 -- 25 June 1601) was the son of Catherine Willoughby, 12th Baroness Willoughby de Eresby, and Richard Bertie.", "pos": "Johann Leopold, Hereditary Prince of Saxe-Coburg and Gotha (Johann Leopold William Albert Ferdinand Victor; 2 August 1906 -- 4 May 1972) was the eldest son of Charles Edward, Duke of Saxe-Coburg and Gotha and Princess Victoria Adelaide of Schleswig-Holstein-Sonderburg-Glucksburg.", "neg": "Sir John's considerable wealth in Barbados passed to his son, Major Sir William Yeamans, second baronet, and great-grandfather of Sir John Yeamans of Barbados, whose son, Sir Robert (d. 19 February 1788), was the last baronet.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}224{"query": "Nicholas Barre, O.M. (21 October 1621 -- 31 May 1686), was a French Minim friar and Catholic priest, who founded the Sisters of the Infant Jesus.", "pos": "Barbeau Abbey (French: Abbaye de Barbeau or Abbaye Notre-Dame de Barbeau; Latin: Barbelum, Sequanae portus or Sacer portus) is a former Cistercian monastery in Fontaine-le-Port in the Seine-et-Marne department, France.", "neg": "Riseberga Abbey (Swedish: Riseberga kloster), was a Cistercian nunnery in Sweden, in operation from cirka 1180 until 1534.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}225{"query": "The film begins some years in the future from this exact moment. We see ads everywhere (buildings, walls, bus stops, e.t.c) for the hit game Slayers, and how the star character Kable (Gerard Butler) has four battles left before he earns his freedom. We are then shown a battle in progress: a massive shootout inside a factory. Everyone in the game is controlled by players elsewhere. Characters get points for each kill and for saving a teammate. Some characters are shown to be doing menial tasks in the battlefield, seemingly unaware of all the violence around them. 17-year-old Simon (Logan Lerman) plays/controls Kable and leads him around the factory. After slaughtering most everyone in his way, Kable gets blasted outside of the factory. Kable manages to run to the safe point to win the battle. Afterward, the surviving characters are transported elsewhere. The other characters congratulate Kable on winning, since he now only has three battles left until freedom. Some of the other characters don't believe that anyone will be released from the game.The producer (Michael Weston) and Chief of Staff, Bob, (John de Lancie) for the Gina Parker Smith Show discuss their next guest for the show - genius recluse Ken Castle, the creator of Slayers. On the show, Gina (Kyra Sedgwick) talks about the achievements of Ken Castle (Michael C. Hall). He first created a game called Society, which is basically a Sims game but instead of controlling a fake character, the players control a real person and can make them do whatever they want. You can pay to control someone else, or you can get paid to be controlled. Society quickly became extremely popular and profitable, making Castle the richest person in the universe. Nine months ago Castle created Slayers, a controversial game which is supported by the federal government. Castle defends Slayers by stating that each character in the game, though they are real people, are all death row inmates who chose to sign up for the game instead of doing their prison sentence. If a convict can stay alive for thirty battles, they will be set free (though no one has ever survived that long). Some convicts are sent into battlefields with pre-engineered actions to do, and will be set free if they survive just one battle, but are unable to defend themselves (which makes their death rate extremely high). Also, the games are all televised on pay-per-view. Everyone in Slayers and Society has had nano-cells implanted into their brains, which makes it possible for them to be controlled by someone else. They can only be controlled in the perimeter of the game (meaning after the game is over, they get their control back).After the show is over, the signal is hacked into by Humanz, a resistance group. The Humanz Brother (Ludacris) condemns Castle and states that eventually we will all be his slaves if we continue down this road. Castle gets a kick out of it and has his men try to locate where the signal came from. In prison, a convict beats a guard to death and tries to escape but in the end, he fails. Kable sits by himself and thinks about his family. Freek (John Leguizamo) sits next to Kable. He talks about how Kable spooks everyone else when he sits by himself and is constantly thinking. He can't believe that Kable only has three battles left. Freek asks him why he's in prison. Kable has a quick flashback of a man bleeding in a room. Later on, while sitting in his cell, someone opens the slot of the door and hands Kable a picture of his wife and child. The female voice on the other side knows that his family is the only thing he fights for. She makes Kable sign an autograph for her son, David, and then takes a blood sample from his hand as proof of authenticity to increase the value of the autograph.Elsewhere, we see Kable's wife Angie (Amber Valletta) going to work as a character in Society. Practically all the game characters are dressed in ridiculous and skimpy costumes", "pos": "The Men in Black are a secret law-enforcement agency that is responsible for policing the extraterrestrial life hidden on Earth, as well as protecting the world from any aliens who attempt to destroy/invade the planet.The film begins on LunarMax, a MiB prison situated on the moon. A one-armed criminal, a Boglodite named Boris the Animal, stages a jailbreak (along the way killing Obadiah Price, a fellow inmate he'd made a deal with). His intention is to rewrite history, with Agent K, the one who arrested and imprisoned him, being a major factor in his plan...On Earth, Agent K and his partner Agent J cover up an arrival of an alien spacecraft, and hear of the prison break. At a Chinese restaurant thats a local haunt for aliens, Agent K discovers Boris (who had previously gone to see Obadiah's son Jeffrey) and the two fight, with J joining in. K is upset that the alien he should have killed is out loose again; he deems it his own affair and forbids J to help him, suspending him. A puzzled J checks up on Boris: he appeared in 1969 to stop the prevention of the ArcNet Shield, a device that K deployed to protect the world from harm (but which killed off the Boglodites, as they can only survive by feeding off worlds). He managed to kill on 15 July 1969 an alien named Roman the Fabulous and on the following day... at this point O cuts him off and tells him not to investigate any further. That night, as K waits for Boris with a gun in his hand, he suddenly vanishes...The next morning, J discovers that he has a new partner, the liberated Agent AA, and that K has been dead for forty years (having been killed by Boris the Animal on 16th July 1969). O notices he is suffering from headaches and craves chocolate milk, which she explains are symptoms of time-fracture (aka the crime of interfering with history, which Obadiah Price was imprisoned for). At this point a Boglodite armada appears; J learns that there was nothing to hold them at bay, with no K to deploy the ArcNet. He theorizes that Boris went back in time to 1969 to kill K, thus changing history to what it was, and proposes to follow him; he heads to Jeffrey Price, who had provided Boris a time-jump device, and gets another one from him, and activates it by jumping off the Chrysler Building just as the Boglodites begin their assault...J arrives in 15 July 1969, with the intention to catch Boris as he is about to murder Roman the Fabulous. However, he is delayed from navigating the era of 1969 (most notably by an altercation with two racist cops), and gets there too late to stop Romans murder by 1969 Boris. He encounters 1969 Agent K, who subdues him and brings him to MiB headquarters. J tells K nothing, but when threatened with getting his memory erased he tells K part of the truth: he came from the future in pursuit of another time-traveler whos trying to change history.K and J follow a trail of clues to Andy Warhols Factory complex, where Warhol is revealed to be MiB Agent W. He notifies them of Griffin, an Arcanian being who has the ability to foresee all timelines and futures; Griffins planet was destroyed by the Boglodites, so he came to live on Earth and brought with him a device which will prevent the Boglodites from consuming the Earth. 1969 Boris arrives at the Factory in search of Griffin, who makes a quick exit with Boris in fast pursuit (to Js displeasure, although K doesnt seem to get too worried).J and K eventually track down Griffin at Shea Stadium, where he is foreseeing the future victory for the Mets baseball team. 1969 Boris appears and captures Griffin, but J and K are able to rescue Griffin, although Boris gets away. Griffin gives them the ArcNet and explains it can only work in zero gravity: K gets the idea to head to Cape Canaveral on 16th July 1969 (the day the Apollo 11 ship launched)", "neg": "Lindsay (Ashley C. Williams) and Jenny (Ashlynn Yennie), two American tourists in Germany, are drugged and involuntarily detained by crazed surgeon Dr. Josef Heiter (Dieter Laser) when they seek help at his house after they get a flat tire. The women awake in a makeshift medical ward. They witness Heiter kill a kidnapped truck driver after Heiter informs him he is \"not a match\". Heiter secures a new male captive, Japanese tourist Katsuro (Akihiro Kitamura). The doctor explains that he is a world-renowned expert at separating Siamese twins, but dreams of making new creatures by sewing people together. He describes in detail how he will surgically connect his three victims mouth-to-anus, so that they share a single digestive system. After Lindsay tries to escape and fails, Heiter explains that he had previously experimented with creating what he called a \"three-dog\", also joined mouth-to-anus. However, the three-dog died shortly after surgery. Heiter tells Lindsay that one dog tried to escape and that dog became the middle, thus this caused the most pain to the dog and as punishment for her escape attempt, she will become the middle part of his centipede. Heiter performs the surgery, placing Katsuro at the front, Lindsay in the middle and Jenny at the rear. He removes the front teeth of both women and mutilates the buttocks of both Katsuro and Lindsay in order to provide easier access to the rectums, to which he hideously stitches and grafts their mouths. During his procedure, he severs the ligaments within his victims' knees to prevent leg extension, forcing his victims to crawl. He then connects his victims together in a straight line with their mouths surgically attached to the anus of the victim in front of them. Once the operation is complete, Heiter attempts to train his centipede as a pet, often belittling Katsuro with racist insults and beating him with a crop when he becomes rebellious. When Katsuro defecates, Lindsay is forced to swallow his excrement while the doctor watches in delight. However, he eventually becomes irritated after being kept awake by the constant screaming of Katsuro (who, as the front part of the centipede, has his mouth free and is still able to speak) and the realization that Jenny is dying from septicemia. When two detectives, Kranz (Andreas Leupold) and Voller (Peter Blankenstein), visit the house to investigate the disappearance of tourists, Heiter comes up with an idea to add them as replacements for Jenny in a new creation; a four-segment centipede. He offers the two detectives water spiked with sedatives in hopes of knocking the two unconscious. After being given the water, the detectives become suspicious and obtain a search warrant for his home. While the detectives leave Heiter's home, the victims attempt to escape. Katsuro attacks Heiter in the process. Their attempt to escape ultimately fails. Katsuro confesses to the doctor that he deserves his fate because he had treated his own family poorly, then commits suicide by slitting his throat with a glass shard. Upon returning to Heiter's home, the detectives forcefully conduct separate searches as an injured Heiter hides near his swimming pool. Kranz finds the ward along with Heiter's victims. Voller begins to feel ill from the earlier drugging, and Heiter stabs him with the scalpel pulled from his leg during Katsuro's attack. Upon finding Voller dead, Kranz is shot by Heiter with Voller's sidearm. Kranz responds by shooting Heiter in the head before dying. Back in the house, Jenny and Lindsay hold hands as Jenny dies. Lindsay sobs as she is left alone in the house, trapped between her deceased fellow captives. Her fate is left unknown. The film ends with the sounds of her sobbing while the camera pans to the roof of the house.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}226{"query": "Playing again without Calvin Johnson, the Lions fell behind the visiting New Orleans Saints by two scores on two separate occasions, before mounting a dramatic comeback in the final minutes of the game. New Orleans had three of the first four scoring plays of the game. Drew Brees hit Austin Johnson with a 14-yard TD pass, Shayne Graham made good on a 27-yard field goal, and Kenny Stills caught a 46-yard TD pass from Brees. Meanwhile, the Lions could only muster a 21-yard field goal by Matt Prater, falling behind 17-3. Detroit closed the gap to 17-10 in the third quarter after a 1-yard TD run by Joique Bell. Two more Shayne Graham field goals, however, gave the Saints a seemingly comfortable 23-10 lead with 5:24 to play in the game. With under four minutes to play, Matthew Stafford connected with Golden Tate on a 73-yard catch-and-run, making the score 23-17. On the Saints' next possession, Glover Quin picked off a third-and-ten Drew Brees pass, returning it to the New Orleans 14-yard line. At the 1:48 mark, Corey Fuller made a leaping catch of a 5-yard TD pass from Stafford for the winning touchdown in a 24-23 game. The Lions' defense held off the Saints in four downs, then the offense ran out the clock for the win.", "pos": "Coming off their Monday night road win over the Saints, the Vikings went home for a Week 6 NFC North duel with the Detroit Lions. In the first quarter, the Vikes got an early lead as Lions QB Dan Orlovsky unintentionally ran out of the back of his own end zone, giving Minnesota a safety which Orlovsky didn't know why the whistles were blown. In the second quarter, Detroit got the lead as kicker Jason Hanson got a 40-yard field goal. In the third quarter, the Lions increased their lead as Orlovsky completed a 12-yard TD pass to WR Calvin Johnson. The Vikings answered with QB Gus Frerotte completing an 86-yard TD pass to WR Bernard Berrian. In the end of the fourth quarter, the Vikes got in field goal range due to a controversial pass interference call on Leigh Bodden. The Vikes sealed the win with kicker Ryan Longwell nailing the game-winning 26-yard field goal.", "neg": "This game is well known for an infamous penalty that occurred during the overtime period. The Jets were lining up for a game winning 56-yard field goal in overtime to try and give them the win. Nick folk kicked the ball, but the kick went wide right and the Patriots appeared to be taking over with a chance to win. However, Chris Jones of New England was called for a controversial unsportsmanlike conduct penalty after pushing his teammate into the offensive line. This penalty would later be named \"leaping\". The penalty gave the Jets another chance and made the field goal attempt a 51-yard attempt. This time, Folk drilled the kick, and the Jets would go on to stun the Patriots. With the win, the Jets improved to 4-3.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}227{"query": "In Egypt, circa 1290 BC, high priest Imhotep engages in an affair with Anck-su-Namun, the mistress of Pharaoh Seti, despite strict rules that other men are forbidden to touch her. When the Pharaoh discovers their tryst, Imhotep and Anck-su-Namun murder the monarch. Imhotep is dragged away by his priests before the Pharaoh's guards can discover his involvement; Anck-su-Namun then kills herself, intending for Imhotep to resurrect her. After Anck-su-Namun's burial, Imhotep breaks into her crypt and steals her corpse. He and his priests flee across the desert to Hamunaptra, the City of the Dead, where they begin the resurrection ceremony. However, they are caught by Seti's guards before the ritual could be completed, and Anck-su-Namun's soul is sent back to the Underworld. For their sacrilege, Imhotep's priests are mummified alive, and Imhotep himself is forced to endure the curse of Hom Dai: his tongue is cut out and he is buried alive with a swarm of flesh-eating scarabs. The ritual curses him to become an immortal walking plague if he were ever to be resurrected. He is buried under high security, sealed away in a sarcophagus below a statue of the Egyptian god Anubis, and kept under strict surveillance throughout the ages by the Medjai, descendants of Seti's palace guards. If Imhotep were ever to be released, the powers that made him immortal would allow him to unleash a wave of destruction and death upon the Earth.In 1923, soldiers from the French Foreign Legion, led by American Rick O'Connell, make a final stand at Hamunaptra against an overwhelming force of Medjai warriors. The soldiers are massacred and O'Connell makes a final retreat inside the city, only to be cornered by a group of Medjai. However, they flee when Imhotep's evil presence manifests itself, leaving him to die in the desert.In 1926, Cairo librarian and aspiring Egyptologist, Evelyn Carnahan is presented with an intricate box and map by her bumbling brother Jonathan, who says he found it in Thebes. The map seems to point the way to the lost city of Hamunaptra, where all of the wealth of Egypt was supposedly stored; however, the museum curator, Dr. Bey, dismisses Hamunaptra as a myth, and accidentally damages the map. Jonathan reveals he actually stole it from an American (revealed to be O'Connell), who is currently in prison, and may be able to tell more about Hamunaptra. Rick tells them that he knows the location of the city from his days in the Foreign Legion. He makes a deal with Evelyn to reveal the location of Hamunaptra, in exchange for Evelyn saving Rick from being hanged. Evelyn successfully negotiates his release from the prison warden by offering him 25% of the found treasure; however, the warden insist on coming along in order to protect his investment. They board a ship to start their expedition to the city, where they encounter a band of American treasure hunters led by the famed Egyptologist Dr. Allen Chamberlain, and guided by Beni Gabor, a cowardly former Legion soldier who served with Rick and also knows the location of the lost city.During the journey, the boat is invaded by Medjai soldiers who are looking for Evelyn's box and the map. The expedition manages to fight them off, but the map is lost and the boat goes up in flames, forcing the entire party to go ashore. Rick, Evelyn and Jonathan are separated from the other treasure hunters and procure camels at a nearby market. Since Rick knows the way to the city, they arrive at Hamunaptra at the same time as the other party, but due to tensions between the two groups, they start exploring the city in separate locations. The Americans discover a chest between the legs of the statue of Anubis. They have it opened by several of their carriers, but the chest is booby-trapped and the carriers die from an acid spray. In the meanwhile, Evelyn is looking for the Book of Amun-Ra, a solid gold book supposedly capable of taking life away. Her team discovers a tomb buried directly below the statue of Anubis", "pos": "The film opens in 19th century Maryland where several Baltimore policemen are chasing after the screams of a woman in an apartment. The police arrive at the apartment in time only to discover a woman (Jasmina Ilic) sprawled on the floor with her throat sliced open and the corpse of her daughter (Teodora Uveric) stuffed in the chimney. Detective Emmett Fields (Luke Evans) is called to assist in the investigation and discovers that the crime resembles a fictional murder in the short story The Murders in the Rue Morgue, which is part of a collection of stories penned by the writer Edgar Allan Poe (John Cusak).Poe has become a social pariah and penniless drunkard whose stories have not been circulated for some time. He has fallen in love with the beautiful young Emily Hamilton (Alice Eve) and desires to marry her but faces opposition from her father Captain Charles Hamilton (Brendan Gleeson), a military man who loathes Poe and goes to the length of threatening physical violence. Poe is brought to see Fields for questioning and is horrified to learn someone is using his stories as the backdrop for a series of murders. Fields then proposes that Poe volunteer his services to help the police catch the killer and Poe agrees to the task.The two men are called to investigate the murder of literary critic Rufus Griswold (John Warnaby), the man who became Poe's rival after a feud that was published in the Baltimore newspapers. Poe realizes the gruesome crime resembles a scene from The Pit and the Pendulum as Fields notices a red demon mask near the corpse. The two then deduce that the scene of the next crime will take place at Captain Hamilton's annual masquerade ball a scene that will resemble the Masked Ball in The Masque of the Red Death.Fields assigns several members of the Baltimore Police to go undercover as guests at the Masked Ball. Sometime before midnight, at the height of the festivities, a man on horseback dressed in a skeleton costume appears. Fields shoots the man only to learn he was an actor hired for the entertainment and receives an anonymous note. Poe then realizes Emily has been kidnapped, meaning the event was all a distraction. It's revealed in the killer's note that he will continue to commit murders and leave clues to Emily's location. The killer then threatens to kill Emily if Poe does not start writing columns for the newspaper that describe the brutal combination of fact and fiction forcing Poe to comply with the request in order to save Emily.The local Medical School's anatomy class discovers a live raven and the corpse of a prostitute in theatrical clothing. Poe and Fields investigate and deduce the scene resembles The Mystery of Marie Roget except for one detail the blood on the corpse's hands was not an element of Poe's story. The two soon learn the woman was an actress (Ana Sofrenovic) in costume as Lady Macbeth and rush to the theatre where the victim worked, demanding to see all the stage hands. All the stage hands are accounted for except for Maurice Rabichaux (Dejan Cubrilov), a sailor on leave after his ship landed in Baltimore. Poe and Fields notice a mysterious figure running along the catwalks and pursue him but the figure escapes. Fields later makes an off-handed comment that the name of the ship Maurice arrived on is the Fortunato which prompts Poe to realize the next murder will resemble The Cask of Amontillado.Poe and Fields search tunnels under the city with several policemen and discover an area with fresh brickwork, an area that might be where Emily is being held. The officers smash through the brick and discover what appears to be a woman with blonde hair in the costume Emily wore the night she was kidnapped. But the body is revealed to be that of the sailor Maurice, who was dressed to resemble Emily after he was killed and buried in the niche. Two clues are found on Maurice: a pocket watch that was stopped at 12:27 and then stuffed into his mouth, and a tattoo on his back that had some flesh carved out of it. Poe and Fields deduce these clues will give the location of Emily, and Poe realizes a church in Baltimore called Holy Cross is where Emily", "neg": "New Orleans, Louisiana, 1927. An enraged posse of men descend on the isolated Seven Doors Hotel deep in the swamps. They grab an artist called Schweik (Antoine Saint John), who is cloistered there. Accusing him of being a warlock, Schweik is dragged down to the cellar where he is savagely beaten with heavy chains, tortured with quicklime acid, and crucified with his wrists nailed to a cellar wall, despite his dire warnings of evil to be unleashed.New Orleans, 1981. Liza Merril (Catriona MacColl) is a young woman who arrives from New York City to claim the hotel as her inheritance. No sooner has architect friend Marin Avery (Michele Mirabella) begins to show her around the property, strange incidents begin to happen. A painter (Anthony Flees) falls off his rig and is horribly injured, coughing up blood and babbling about, \"the eyes, the eyes.\" Dr. John McCabe (David Warbeck) arrives to take the injured man to the hospital, and offers Liza some sympathy. Next, a plumber, named Joe, attempts to repair a major leak in the flooded cellar. However, he is murdered by a presence that emerged from behind a slim-caked wall. The atmosphere at the hotel is further chilled by the creepy-looking servants, Arthur (Giampaolo Saccarola) and Martha (Veronica Lazar), who apparently come with the hotel. Martha discovers Joe's dead body in the cellar, and another much older cadaver lying in a pool of dirty water nearby. It is apparently that of Schweik, the artist.Driving down the 14-mile causeway to New Orleans, Liza encounters a strange blind woman, standing in the middle of the desolate highway. The blind woman introduces herself as Emily (Sarah Keller), and tells Liza that she has been waiting for her, although her eyes are occluded with cataracts. Liza drives Emily over to her opulently furnished house in New Orleans. Liza is warned by Emily to leave the hotel while she still can. Meanwhile at the hospital morgue, Dr. John McCabe is performing the autopsy on Joe the plumber while his assistant Harris (Al Cliver) wants to install an EMG machine to the corpse of Schweik. John laughs it off and leaves for lunch, while Harris remains behind to install the EMG machine. After Harris leaves for a call, the EMG machine begins pulsing with activity. A little later, Joe's wife Mary-Anne (Laura De Marchi) arrives with her daughter Jill (Maria Pia Marsale) to dress up her husband's corpse for the funeral, when she is killed in a horrific way by scalded with acid. Jill is then menaced by the re-animated cadaver of Schweik.Liza meets with John McCabe in a downtown bar to discuss her misgivings and anxieties. He expresses puzzlement when Lisa complains about he ineptitude of her weird servants. John claims to have never heard of them before despite knowing everyone in the area. Then a phone call from the bar arrives from Harris who informs John that Mary-Anne's body was found in the morgue, while Jill was found huddled in a corner frightened and unable to speak. After Joe and Mary-Anne's funeral, Emily appears again to Liza that evening at the hotel. Emily tells Liza about the warlock Schweik, who stayed in Room 36 of the hotel and about the supernatural underworld that the hotel conceals. The hotel was built over one of the Seven Gates of Hell, and Schweik has been the Guardian. Emily is about to reveal more when her hands wander over to a canvas depicting a desolate vision of lost souls in a terrible and arid landscape. Suddenly afraid, Emily says that the painting was painted by Schweik before he died, and she runs out of the hotel parlor into the night. But Liza notices a disquieting fact about her sudden departure: Emily made no footfalls on the bare wooden boards as she ran, and neither did her seeing-eye dog.The next day, Liza ventures nervously into Room 36, a dingy phantasmal of sheet-covered furniture and shafts of dusty light. She finds an ancient book, whose weirdly flesh-like cover bears the single word", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}228{"query": "Rear Admiral James Edward Jouett (7 February 1826 -- 30 September 1902), known as ''Fighting Jim Jouett of the American Navy'', was an officer in the United States Navy during the Mexican-American War and the American Civil War.", "pos": "Jose Santiago Albarracin 1 (23 July 1800 - 20 April 1869 ) was an Argentine soldier who fought on the Unitarian side in many engagements in the Argentine Civil Wars, especially in the struggles against Chacho Penaloza.", "neg": "Miller Worsley (8 July 1791 -- 2 May 1835) was an officer in the Royal Navy, best known for playing a major part in the Engagements on Lake Huron in the Anglo-American War of 1812.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}229{"query": "In Greek mythology, Dynamene (Ancient Greek: ) was a Nereid or sea-nymph, one of the 50 daughters of Nereus and Doris.", "pos": "Potone (Greek: Potone or Potone; born before 427 BC) daughter of Ariston and Perictione, was Plato's older sister.", "neg": "Birgul Sadkoglu (born March 23, 2000) is a Turkish women's football midfielder currently playing in the Turkish Women's First Football League for Eskisehirspor with jersey number 20.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}230{"query": "Huntley Gordon died in Van Nuys, California and was interred in the Forest Lawn Memorial Park Cemetery in Glendale, California.", "pos": "She was interred as Theda Bara Brabin in Forest Lawn Memorial Park Cemetery in Glendale, California.", "neg": "It's eight o'clock and the time for Morning New Highlights . One person was killed and two were injured in a car accident just thirty minutes ago. Cause of the accident is not yet found out. A great fire swept through a storehouse next to the Fulton River early this morning, causing about $3,000,000 in damage. The fire which broke out at about 2:30 was finally put out at 5: 30. That was the Morning News Highlights, Dan Verne reporting.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}231{"query": "Your bodys first line of defense is like a castles moat and walls. It keeps most pathogens out of your body. The first line of defense includes physical, chemical, and biological barriers. The skin is a very important barrier to pathogens. It is the bodys largest organ and the most important defense against disease. It forms a physical barrier between the body and the outside environment. The outer layer of the skin, called the epidermis, consists of dead cells filled with the protein keratin. These cells form a tough, waterproof covering on the body. It is very difficult for pathogens to get through the epidermis. The inside of the mouth and nose are lined with mucous membranes. Other organs that are exposed to substances from the environment are also lined with mucous membranes. These include the respiratory and digestive organs. Mucous membranes arent tough like skin, but they have other ways of keeping out pathogens. One way mucous membranes protect the body is by producing mucus. Mucus is a sticky, moist secretion that covers mucous membranes. The mucus traps pathogens and particles so they cant enter the body. Many mucous membranes are also covered with cilia. These are tiny, hair-like projections. Cilia move in waves and sweep mucus and trapped pathogens toward body openings. You can see this in the diagram in Figure 21.10. When you clear your throat or blow your nose, you remove mucus and pathogens from your body. In addition to mucus, your body releases a variety of fluids, including tears, saliva, and sweat. These fluids contain enzymes called lysozymes. Lysozymes break down the cell walls of bacteria and kill them. Your stomach contains a very strong acid, called hydrochloric acid. This acid kills most pathogens that enter the stomach in food or water. Urine is also acidic, so few pathogens are able to grow in it. Your skin is covered by millions of bacteria. Millions more live inside your body, mainly in your gastrointestinal tract. Most of these bacteria are helpful. For one thing, they help defend your body from pathogens. They do it by competing with harmful bacteria for food and space. They prevent the harmful bacteria from multiplying and making you sick. Did you ever get a splinter in your skin, like the one in Figure 21.11? It doesnt look like a serious injury, but even a tiny break in the skin may let pathogens enter the body. If bacteria enter through the break, for example, they could cause an infection. These bacteria would then face the bodys second line of defense. If bacteria enter the skin through a splinter or other wound, the area may become red, warm, and painful. These are signs of inflammation. Inflammation is one way the body reacts to infections or injuries. It occurs due to chemicals that are released when tissue is damaged. The chemicals cause nearby blood vessels to dilate, increasing blood flow to the area. The chemicals also attract white blood cells to the area. The white blood cells leak out of the blood vessels and into the damaged tissue. You can see an animation of the inflammatory response by watching this video: MEDIA Click image to the left or use the URL below. URL: The white blood cells that go to a site of inflammation and leak into damaged tissue are called phagocytes. They start eating pathogens and dead cells by engulfing and destroying them. This process is called phagocytosis. You can see how it happens in Figure ??. You can see it in action in the animation at this link: [Link] Phagocytes also release chemicals that cause a fever. A fever is a higher-than-normal body temperature. Normal human body temperature is 98.6 F (37 C). Most bacteria and viruses that infect people reproduce quickly at this temperature. When the temperature rises higher, the pathogens cant reproduce as quickly. Therefore, a fever helps to limit the infection. A fever also causes the immune system to make more white blood cells to fight the infection.", "pos": "Did you know that you see the largest organ in your body every day? You wash it, dry it, cover it up to stay warm, and uncover it to cool off. Yes, your skin is your bodys largest organ. Your skin is part of your integumentary system ( Figure 1.1), which is the outer covering of your body. The integumentary system is made up of your skin, hair, and nails. Skin acts as a barrier that stops water and other things, like soap and dirt, from getting into your body. The skin has many important functions. The skin: Provides a barrier. It keeps organisms that could harm the body out. It stops water from entering or leaving the body. Controls body temperature. It does this by making sweat (or perspiration), a watery substance that cools the body when it evaporates. Gathers information about your environment. Special nerve endings in your skin sense heat, pressure, cold, and pain. Helps the body get rid of some types of waste, which are removed in sweat. Acts as a sun block. A pigment called melanin blocks sunlight from getting to deeper layers of skin cells, which are easily damaged by sunlight. Your skin is always exposed to your external environment, so it gets cut, scratched, and worn down. You also naturally shed many skin cells every day. Your body replaces damaged or missing skin cells by growing more of them. Did you know that the layer of skin you can see is actually dead? As the dead cells are shed or removed from the upper layer, they are replaced by the skin cells below them. Two different layers make up the skin: the epidermis and the dermis ( Figure 1.2). A fatty layer lies under the dermis, but it is not part of your skin. The epidermis is the outermost layer of the skin. It forms the waterproof, protective wrap over the bodys surface. Although the top layer of epidermis is only about as thick as a sheet of paper, it is made up of 25 to 30 layers of cells. The epidermis also contains cells that produce melanin. Melanin is the brownish pigment that gives skin and hair their color. Melanin-producing cells are found in the bottom layer of the epidermis. The epidermis does not have any blood vessels. The lower part of the epidermis receives blood by diffusion from blood vessels of the dermis. Skin is made up of two layers, the epider- mis on top and the dermis below. The tissue below the dermis is called the hy- podermis, but it is not part of the skin. The dermis is the layer of skin directly under the epidermis. It is made of a tough connective tissue. The dermis contains hair follicles, sweat glands, oil glands, and blood vessels ( Figure 1.2). It also holds many nerve endings that give you your sense of touch, pressure, heat, and pain. Do you ever notice how your hair stands up when you are cold or afraid? Tiny muscles in the dermis pull on hair follicles which cause hair to stand up. The resulting little bumps in the skin are commonly called \"goosebumps\" ( Figure 1.3). Glands and hair follicles open out into the epidermis, but they start in the dermis. Oil glands ( Figure 1.2) release, or secrete an oily substance, called sebum, into the hair follicle. Sebum waterproofs hair and the skin surface to prevent them from drying out. It can also stop the growth of bacteria on the skin. It is odorless, but the breakdown of sebum by bacteria can cause odors. If an oil gland becomes plugged and infected, it develops into a pimple. Up to 85% of teenagers get pimples, which usually go away by adulthood. Frequent washing can help decrease the amount of sebum on the skin. Sweat glands ( Figure 1.2) open to the skin surface through skin pores. They are found all over the body. Evaporation of sweat from the skin surface helps to lower skin temperature. The skin also releases excess water, salts, sugars, and other wastes, such as ammonia and urea,", "neg": "The stratum corneum (SC) is the outermost region of the epidermis and plays key roles in cutaneous barrier function in mammals. The SC is composed of 'bricks', represented by flattened, protein-enriched corneocytes, and 'mortar', represented by intercellular lipid-enriched layers. As a result of this 'bricks and mortar' structure, the SC can be considered as a 'rampart' that encloses water and solutes essential for physiological homeostasis and that protects mammals from physical, chemical and biological assaults. The corneocyte cytoskeleton contains tight bundles of keratin intermediate filaments aggregated with filaggrin monomers, which are subsequently degraded into natural moisturizing compounds by various proteases, including caspase 14. A cornified cell envelope is formed on the inner surface of the corneocyte plasma membrane by transglutaminase-catalysed cross-linking of involucrin and loricrin. Ceramides form a lipid envelope by covalently binding to the cornified cell envelope, and extracellular lamellar lipids play an important role in permeability barrier function. Corneodesmosomes are the main adhesive structures in the SC and are degraded by certain serine proteases, such as kallikreins, during desquamation. The roles of the different SC components, including the structural proteins in corneocytes, extracellular lipids and some proteins associated with lipid metabolism, have been investigated in genetically engineered mice and in naturally occurring hereditary skin diseases, such as ichthyosis, ichthyosis syndrome and atopic dermatitis in humans, cattle and dogs.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}232{"query": "In 2009, 78.5% of Dallas (city) commuters drive to work alone. The 2009 modal share for Dallas (city) commuters are 10.7% for carpooling, 3.9% for transit, 1.9% for walking, and .1% for cycling. In 2015, the American Community Survey estimated modal shares for Dallas (city) commuters of 75.4% for driving alone, 12.8% for carpooling, 3.5% for riding transit, 1.9% for walking, and .2% for cycling. The city of Dallas has a higher than average percentage of households without a car. In 2015, 10.2 percent of Dallas households lacked a car, and decreased to 9.1 percent in 2016. The national average was 8.7 percent in 2016. Dallas averaged 1.59 cars per household in 2016, compared to a national average of 1.8.", "pos": "The U.S. Census for 2010 reported 332,199 households in Indianapolis, with an average household size of 2.42 and an average family size of 3.08. Of the total households, 59.3% were family households, with 28.2% of these including the familys own children under the age of 18; 36.5% were husband-wife families; 17.2% had a female householder (with no husband present) and 5.6% had a male householder (with no wife present). The remaining 40.7% were non-family households. , 32% of the non-family households included individuals living alone, 8.3% of these households included individuals age 65 years of age or older.", "neg": "It does not come as a surprise that Dubai has a growing problem with tragic.The local rulers have explored all the conventional ways to get traffic moving again,including higher prices for parking,fuel and insurance.But at a recent conference in Hamburg,Hussain Lootah said that the city may adopt a more strict approach:setting an income level for vehicle ownership. Mr Lootah's approach is unlikely to be copied widely,but mayors of other big cities around the world are starting to think about taking severe actions of their own,including complete car bans in inner cities.But the efforts may not be enough to reduce traffic and pollution.The problems will only get worse:the number of vehicles sold globally each year will grow from around 80 million today to more than 100 million by the end of the decade,according to IHS Automotive.[] There are already a handful of car-free communities around the world.But these are typically small and often tourist destinations that seek to create a throwback in time,such as Sark Island,in the English Channel.The largest ear-free urban area is probably Venice,where it is impossible to build roads and bridges to link the more than 100 small islands the city sits on. Yet pedestrian malls and other car-free zones keep popping up in cities around the world.Some cities are considering ways to limit central city access to\"green\"machines,such as battery-electric vehicles.Hamburg is perhaps the furthest along. Such extreme plans may fly in a city such as Hamburg.But in many other cities the political resistance even to less far-reaching measures is hard to overcome.Michael Bloomberg,New York's former mayor,tried twice to introduce a jam charge for much of Manhattan,but his plans were rejected by state lawmakers.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}233{"query": "Gravity has traditionally been defined as a force of attraction between two masses. According to this conception of gravity, anything that has mass, no matter how small, exerts gravity on other matter. The effect of gravity is that objects exert a pull on other objects. Unlike friction, which acts only between objects that are touching, gravity also acts between objects that are not touching. In fact, gravity can act over very long distances. You are already very familiar with Earths gravity. It constantly pulls you toward the center of the planet. It prevents you and everything else on Earth from being flung out into space as the planet spins on its axis. It also pulls objects above the surface, from meteors to skydivers, down to the ground. Gravity between Earth and the moon and between Earth and artificial satellites keeps all these objects circling around Earth. Gravity also keeps Earth moving around the sun. Weight measures the force of gravity pulling on an object. Because weight measures force, the SI unit for weight is the newton (N). On Earth, a mass of 1 kilogram has a weight of about 10 newtons because of the pull of Earths gravity On the moon, which has less gravity, the same mass would weigh less. Weight is measured with a scale, like the spring scale in Figure 13.16. The scale measures the force with which gravity pulls an object downward. People have known about gravity for thousands of years. After all, they constantly experienced gravity in their daily lives. They knew that things always fall toward the ground. However, it wasnt until Sir Isaac Newton developed his law of gravity in the late 1600s that people really began to understand gravity. Newton is pictured in Figure 13.17. Newton was the first one to suggest that gravity is universal and affects all objects in the universe. Thats why his law of gravity is called the law of universal gravitation. Universal gravitation means that the force that causes an apple to fall from a tree to the ground is the same force that causes the moon to keep moving around Earth. Universal gravitation also means that while Earth exerts a pull on you, you exert a pull on Earth. In fact, there is gravity between you and every mass around you your desk, your book, your pen. Even tiny molecules of gas are attracted to one another by the force of gravity. Newtons law had a huge impact on how people thought about the universe. It explains the motion of objects not only on Earth but in outer space as well. You can learn more about Newtons law of gravity in the video at this URL: Newtons law also states that the strength of gravity between any two objects depends on two factors: the masses of the objects and the distance between them. Objects with greater mass have a stronger force of gravity. For example, because Earth is so massive, it attracts you and your desk more strongly than you and your desk attract each other. Thats why you and the desk remain in place on the floor rather than moving toward one another. Objects that are closer together have a stronger force of gravity. For example, the moon is closer to Earth than it is to the more massive sun, so the force of gravity is greater between the moon and Earth than between the moon and the sun. Thats why the moon circles around Earth rather than the sun. This is illustrated in Figure You can apply these relationships among mass, distance, and gravity by designing your own roller coaster at this URL: . Newtons idea of gravity can predict the motion of most but not all objects. In the early 1900s, Albert Einstein came up with a theory of gravity that is better at predicting how all objects move. Einstein showed mathematically that gravity is not really a force in the sense that Newton thought. Instead, gravity is a result of the warping, or curving, of space and time. Imagine a bowling ball pressing down on a trampoline. The surface of the trampoline would curve downward instead of being flat. Einstein theorized that Earth and other very massive bodies affect space and time around them", "pos": "In the late 1600s, Isaac Newton introduced his law of gravity, which identifies gravity as a force of attraction between all objects with mass in the universe. The law also states that the strength of gravity between two objects depends on their mass and distance apart. Newtons law of gravity was accepted for more than two centuries. It can predict the motion of most objects and was even used by NASA to land astronauts on the moon. Its still used for most practical purposes. However, Newtons law doesnt explain why gravity occurs. It only describes how gravity seems to affect objects. There are also some cases in which Newtons law doesnt even describe what happens. Q: Newton expressed his ideas about gravity as a law. A law in science is a description of what always occurs in nature. For example, according to Newtons law, objects on Earth always fall down, not up. What is needed to explain gravity? A: A theory is needed to explain gravity. In science, a theory is a broad explanation that is supported by a great deal of evidence. In the early 1900s, Albert Einstein came up with a theory of gravity that actually explains gravity rather than simply describing its effects. Einstein showed mathematically that gravity is not really a force that of attraction between all objects with mass, as Newton thought. Instead, Einstein showed that gravity is a result of the warping, or curving, of space and time, which made up the same space-time fabric. These ideas about space-time and gravity became known as Einsteins theory of general relativity. Einstein derived his theory using mathematics. However, you can get a good grasp of it with the help of a simple visual analogy. Imagine a bowling ball pressing down on a trampoline. The surface of the trampoline would curve downward instead of being flat. Now imagine placing a lighter ball at the edge of the trampoline. What will happen? It will roll down toward the bowling ball. This apparent attraction to the bowling ball occurs because the trampoline curves downward, not because the two balls are actually attracted to one another by an invisible force called gravity. Einstein theorized that the sun and other very massive bodies affect space and time around them in a way that is similar to the effect of the bowling ball on the trampoline. The more massive a body is, the more it causes space-time to curve. This idea is represented by the Figure 1.1. According to Einstein, objects move toward one another because of the curves in space-time, not because they are pulling on each other with a force of attraction. Einsteins theory is supported by evidence and widely accepted today, although Newtons law is still used for many calculations.", "neg": "The Moon is Earths only natural satellite, a body that moves around a larger body in space. The Moon orbits Earth for the same reason Earth orbits the Sun gravity. The Moon is 3,476 km in diameter, about one-fourth the size of Earth. The satellite is also not as dense as the Earth; gravity on the Moon is only one-sixth as strong as it is on Earth. An astronaut can jump six times as high on the Moon as on Earth! The Moon makes one complete orbit around the Earth every 27.3 days. The Moon also rotates on its axis once every 27.3 days. Do you know what this means? The same side of the Moon always faces Earth, so that side of the Moon is what we always see in the night sky (Figure 1.1). The Moon makes no light of its own, but instead only reflects light from the Sun. (a) The near side of the Moon faces Earth continually. It has a thinner crust with many more maria (flat areas of basaltic rock). (b) The far side of the Moon has only been seen by spacecraft. It has a thicker crust and far fewer maria (flat areas of basaltic rock). The Moon has no atmosphere. Since an atmosphere moderates temperature, the Moons average surface temperature during the day is approximately 225 F, but drops to -243 F at night. The coldest temperatures, around -397 F, occur in craters in the permanently shaded south polar basin. These are among the coldest temperatures recorded in the entire solar system. Earths landscape is extremely varied, with mountains, valleys, plains and hills. This landscape is always changing as plate tectonics builds new features and weathering and erosion destroys them. The landscape of the Moon is very different. With no plate tectonics, features are not built. With no atmosphere, features are not destroyed. Still, the Moon has a unique surface. Lunar surface features include the bowl-shaped craters that are caused by meteorite impacts (Figure 1.2). If Earth did not have plate tectonics or erosion, its surface would also be covered with meteorite craters. Even from Earth, the Moon has visible dark areas and light areas. The dark areas are called maria, which means seas because thats what the ancients thought they were. In fact, the maria are not water but solid, flat areas of basaltic lava. From about 3.0 to 3.5 billion years ago the Moon was continually bombarded by meteorites. Some of these meteorites were so large that they broke through the Moons newly formed surface. Then, magma flowed out and filled the craters. Scientists estimate this meteorite-caused volcanic activity on the Moon ceased about 1.2 billion years ago, but most occurred long before that. The lighter parts of the Moon are called terrae or highlands (Figure 1.3). The terrae are higher than the maria and A crater on the surface of the Moon. include several high mountain ranges. The terrae are the light silicate minerals that precipitated out of the ancient magma ocean and formed the early lunar crust. There are no lakes, rivers, or even small puddles anywhere to be found on the Moons surface, but water in the form of ice has been found in the extremely cold craters and bound up in the lunar soil. Despite the possible presence of water, the lack of an atmosphere and the extreme temperatures make it no surprise to scientists that the Moon has absolutely no evidence of life. Life from Earth has visited the Moon and there are footprints of astronauts on the lunar surface. With no wind, rain, or living thing to disturb them, these footprints will remain as long as the Moon exists. Only an impact with a meteorite could destroy them. Like Earth, the Moon has a distinct crust, mantle, and core. What is known about the Moons interior was determined from the analysis of rock samples gathered by astronauts and from unmanned spacecraft sent to the Moon (Figure The Moons small core, 600 to 800 kilometers in diameter, is mostly iron with some sulfur and nickel. The mantle is composed of the minerals olivine and orthopyroxene. Analysis of Moon rocks", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}234{"query": "The Steelers stayed home for a 3-game home stand and for a Sunday Night duel against the Ravens. The Ravens scored first when Joe Flacco hooked up with Torrey Smith 35-yard TD pass to take a 7-0 lead for the only score of the first quarter. In the 2nd quarter, the Steelers managed to tie the game up when Ben Roethlisberger found Le'Veon Bell on a 5-yard TD pass for a 7-7 game. They eventually took the lead when Roethlisberger found Martavis Bryant on a 19-yard TD pass to make it a 14-7 game. The Ravens came within 4 as Justin Tucker kicked a 46-yard field goal to make it 14-10 game. However, the Steelers would manage to go ahead by 12 before halftime when Roethlisberger found Markus Wheaton on a 47-yard TD pass followed by a successful 2-point conversion for a 22-10 lead at halftime. After a scoreless 3rd quarter, the Steelers came out strong and went back to work in the 4th when Roethlisberger found Antonio Brown on a 54-yard TD pass making the score 29-10. The Ravens responded with a big play as Jacoby Jones ran a 108-yard kickoff return for a TD to make it a 29-17 game. Roethlisberger found Bryant again on an 18-yard TD pass to make the score 36-17. This was followed by the Ravens trying their hand at coming back when Flacco found Crockett Gillmore on a 1-yard TD pass (with a failed 2-point conversion) for a 36-23 score. But the Steelers were able to seal the game when Roethlisberger found Matt Spaeth on a 33-yard TD pass for a final score of 43-23. A week after passing for a franchise-record six touchdowns against Indianapolis, Roethlisberger duplicated the feat to lead Pittsburgh to its third consecutive win. The 12 touchdown passes over the last two games broke the NFL record of 11 set by Tom Flores for Oakland in the AFL in 1963 and matched by New England's Tom Brady in 2007.", "pos": "Hoping to build on their home win over the Jets, the Browns flew to Qualcomm Stadium to take on the throwback-clad San Diego Chargers. In the first quarter, things started off close with Chargers kicker Nate Kaeding getting a 29-yard field goal, while Browns kicker Phil Dawson nailed a 37-yarder. In the second quarter, Dawson would get a 20-yard field goal for Cleveland. However, San Diego got the first touchdown of the game, as LB Marques Harris recovered a fumble in the Browns endzone for a touchdown. Dawson would supply the scoring for Cleveland for the rest of the half, as he nailed a 42-yarder and a 30-yarder. In the third quarter, the Chargers gained some momentum, as RB LaDainian Tomlinson, after getting bottled up in the first half, broke out with a 41-yard TD run for the only score of the period. In the fourth quarter, Dawson would get another field goal, which came from 36 yards out. However, San Diego would respond with Tomlinson getting a 7-yard TD run. Cleveland would have Dawson get a 35-yard field goal, yet Tomlinson would get an 8-yard TD run, which was followed by a successful two-point conversion from QB Philip Rivers to WR Vincent Jackson. The Browns would finally get a touchdown, as QB Charlie Frye completed a 4-yard TD pass to WR Braylon Edwards. Unfortunately, the damage was already done. With the loss, Cleveland would fall to 2-6.", "neg": "Hoping to maintain their winning streak, the Steelers flew to LP Field for an AFC Duel with the Titans. The Steelers wasted no time getting the early lead when on the opening kickoff, Mewelde Moore handed the ball off to rookie wide receiver Antonio Brown, who returned it 89yards for a touchdown. Tennessee would cut the lead when Rob Bironas nailed a 21-yard field goal. Throughout the rest of the game, Pittsburgh scored steadily with kicker Jeff Reed, who hit field goals of 36, 34, 25, and 27yards, putting the Steelers up 19-3. The Titans finally scored a touchdown in the fourth quarter with a Kerry Collins 2-yard pass to former Steeler Nate Washington, and successfully converted the 2-point conversion and onside kick necessary to give themselves the chance to tie the game on the final drive. However, Pittsburgh's defense was able to stop Chris Johnson on a reception as the clock ran out, sealing the victory. Starting quarterback Dennis Dixon sprained his left knee during the second quarter and was replaced by Charlie Batch, but the Steelers defense swarmed the Titans, coming up with four sacks and forcing seven turnovers, the most by Tennessee since 2000. The Titans pulled their starting QB, Vince Young, after his third turnover. After replacing Young, Kerry Collins had two turnovers of his own. Pittsburgh also ended Tennessee running back Chris Johnson's 100-yard rushing streak at 12 games. The NFL's rushing champion had a chance to move one game away from the league record of 14 held by Barry Sanders, but he finished with just 16 carries for 34yards. Steelers linebacker James Harrison had three sacks, forced a fumble and recovered another. Safety Troy Polamalu was credited for an interception and an impressive leaping tackle on Kerry Collins during an attempted goal-line stand by the Steelers to win the game and improve to 2-0.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}235{"query": "Mendeleev was a teacher as well as a chemist. He was writing a chemistry textbook and needed a way to organize the elements so it would be easier for students to learn about them. He made a set of cards of the elements, similar to a deck of playing cards, with one element per card. On the card, he wrote the elements name, atomic mass, and known properties. He arranged and rearranged the cards in many different ways, looking for a pattern. He finally found it when he placed the elements in order by atomic mass. You can see how Mendeleev organized the elements in Figure 6.2. From left to right across each row, elements are arranged by increasing atomic mass. Mendeleev discovered that if he placed eight elements in each row and then continued on to the next row, the columns of the table would contain elements with similar properties. He called the columns groups. They are sometimes called families, because elements within a group are similar but not identical to one another, like people in a family. Mendeleevs table of the elements is called a periodic table because of its repeating pattern. Anything that keeps repeating is referred to as periodic. Other examples of things that are periodic include the monthly phases of the moon and the daily cycle of night and day. The term period refers to the interval between repetitions. In a periodic table, the periods are the rows of the table. In Mendeleevs table, each period contains eight elements, and then the pattern repeats in the next row. Did you notice the blanks in Mendeleevs table (Figure 6.2)? They are spaces that Mendeleev left for elements that had not yet been discovered when he created his table. He predicted that these missing elements would eventually be discovered. Based on their position in the table, he could even predict their properties. For example, he predicted a missing element in row 5 of his group 3. He said it would have an atomic mass of about 68 and be a soft metal like other group 3 elements. Scientists searched for the missing element. They found it a few years later and named it gallium. Scientists searched for the other missing elements. Eventually, all of them were found. An important measure of a good model is its ability to make accurate predictions. This makes it a useful model. Clearly, Mendeleevs periodic table was a useful model. It helped scientists discover new elements and make sense of those that were already known. A periodic table is still used today to classify the elements. Figure 6.3 shows the modern periodic table. You can see an interactive version at this URL: . In the modern periodic table, elements are organized by atomic number. The atomic number is the number of protons in an atom of an element. This number is unique for each element, so it seems like an obvious way to organize the elements. (Mendeleev used atomic mass instead of atomic number because protons had not yet been discovered when he made his table.) In the modern table, atomic number increases from left to right across each period. It also increases from top to bottom within each group. How is this like Mendeleevs table? Besides atomic number, the periodic table includes each elements chemical symbol and class. Some tables include other information as well. The chemical symbol consists of one or two letters that come from the chemicals name in English or another language. The first letter is always written in upper case. The second letter, if there is one, is always written in lower case. For example, the symbol for lead is Pb. It comes from the Latin word plumbum, which means \"lead.\" Find lead in Figure 6.3. What is its atomic number? You can access videos about lead and other elements in the modern periodic table at this URL: . The classes of elements are metals, metalloids, and nonmetals. They are color-coded in the table. Blue stands for metals, orange for metalloids, and green for nonmetals. You can read about each of these three classes of elements later in the chapter, in the lesson \"Classes of Elements.", "pos": "Figure 5.1 represents a simple model of an atom. You will learn about more complex models in later lessons, but this model is a good place to start. You can see similar, animated models of atoms at this URL: [Link] At the center of an atom is the nucleus (plural, nuclei). The nucleus contains most of the atoms mass. However, in size, its just a tiny part of the atom. The model in Figure 5.1 is not to scale. If an atom were the size of a football stadium, the nucleus would be only about the size of a pea. The nucleus, in turn, consists of two types of particles, called protons and neutrons. These particles are tightly packed inside the nucleus. Constantly moving about the nucleus are other particles called electrons. You can see a video about all three types of atomic particles at this URL: (1:57). A proton is a particle in the nucleus of an atom that has a positive electric charge. All protons are identical. It is the number of protons that gives atoms of different elements their unique properties. Atoms of each type of element have a characteristic number of protons. For example, each atom of carbon has six protons, as you can see in Figure A neutron is a particle in the nucleus of an atom that has no electric charge. Atoms of an element often have the same number of neutrons as protons. For example, most carbon atoms have six neutrons as well as six protons. This is also shown in Figure 5.2. An electron is a particle outside the nucleus of an atom that has a negative electric charge. The charge of an electron is opposite but equal to the charge of a proton. Atoms have the same number of electrons as protons. As a result, the negative and positive charges \"cancel out.\" This makes atoms electrically neutral. For example, a carbon atom has six electrons that \"cancel out\" its six protons. When it comes to atomic particles, opposites attract. Negative electrons are attracted to positive protons. This force of attraction keeps the electrons moving about the nucleus. An analogy is the way planets orbit the sun. What about particles with the same charge, such as protons in the nucleus? They push apart, or repel, each other. So why doesnt the nucleus fly apart? The reason is a force of attraction between protons and neutrons called the strong force. The name of the strong force suits it. It is stronger than the electric force pushing protons apart. However, the strong force affects only nearby particles (see Figure 5.3). It is not effective if the nucleus gets too big. This puts an upper limit on the number of protons an atom can have and remain stable. You can learn more about atomic forces in the colorful tutorial at this URL: . Electrons have almost no mass. Instead, almost all the mass of an atom is in its protons and neutrons in the nucleus. The nucleus is very small, but it is densely packed with matter. The SI unit for the mass of an atom is the atomic mass unit (amu). One atomic mass unit equals the mass of a proton, which is about 1.7 10 24 g. Each neutron also has a mass of 1 amu. Therefore, the sum of the protons and neutrons in an atom is about equal to the atoms total mass in atomic mass units. Two numbers are commonly used to distinguish atoms: atomic number and mass number. Figure 5.4 shows how these numbers are usually written. The atomic number is the number of protons in an atom. This number is unique for atoms of each kind of element. For example, the atomic number of all helium atoms is 2. The mass number is the number of protons plus the number of neutrons in an atom. For example, most atoms of helium have 2 neutrons, so their mass number is 2 + 2 = 4. This mass number means that an atom of helium has a mass of about 4 amu. Problem Solving Problem: An atom has an atomic number of 12 and a", "neg": "Eukaryotic cells have many specific functions, so it can be said that a cell is like a factory. A factory has many machines and people, and each has a specific role. Just like a factory, the cell is made up of many different parts. Each part has a special role. The different parts of the cell are called organelles, which means \"small organs.\" All organelles are found in eukaryotic cells. Prokaryotic cells are \"simpler\" than eukaryotic cells. Though prokaryotic cells still have many functions, they are not as specialized as eukaryotic cells, lacking membrane-bound organelles. Thus, most organelles are not found in prokaryotic cells. Below are the main organelles found in eukaryotic cells ( Figure 1.1): 1. The nucleus of a cell is like a safe containing the factorys trade secrets. The nucleus contains the genetic material (DNA), the information needed to build thousands of proteins. 2. The mitochondria are the powerhouses of the cell. Mitochondria are the organelles where cellular energy is produced, providing the energy needed to power chemical reactions. This process, known as cellular respiration, produces energy is in the form of ATP (adenosine triphosphate). Cells that use a lot of energy may have thousands of mitochondria. 3. Vesicles are small membrane bound sacs that transport materials around the cell and to the cell membrane. 4. The vacuoles are like storage centers. Plant cells have larger vacuoles than animal cells. Plants store water and nutrients in their large central vacuoles. 5. Lysosomes are like the recycling trucks that carry waste away from the factory. Lysosomes have digestive enzymes that break down old molecules into parts that can be recycled. 6. In both eukaryotes and prokaryotes, ribosomes are the non-membrane bound organelles where proteins are made. Ribosomes are like the machines in the factory that produce the factorys main product. Proteins are the main product of the cell. 7. Some ribosomes can be found on folded membranes called the endoplasmic reticulum (ER), others float freely in the cytoplasm. If the ER is covered with ribosomes, it looks bumpy like sandpaper, and is called the rough endoplasmic reticulum. If the ER does not contain ribosomes, it is smooth and called the smooth endoplasmic reticulum. Many proteins are made on the ribosomes on the rough ER. These proteins immedi- ately enter the ER, where they are modified, packaged into vesicles and sent to the Golgi apparatus. Lipids are made in the smooth ER. 8. The Golgi apparatus works like a mail room. The Golgi apparatus receives proteins from the rough ER and puts \"shipping addresses\" on them. The Golgi then packages the proteins into vesicles and sends them to the right place in the cell or to the cell membrane. Some of these proteins are secreted from the cell (they exit the cell); others are placed into the cell membrane. Also, the cytoskeleton gives the cell its shape, and the flagella helps the cell to move. Prokaryotic cells may also have flagella.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}236{"query": "So that people in developed nations maintain a good lifestyle and people in developing nations have the ability to improve their lifestyles, natural resources must be conserved and protected (Figure 1.1). People are researching ways to find renewable alternatives to non-renewable resources. Here is a checklist of ways to conserve resources: Buy less stuff (use items as long as you can, and ask yourself if you really need something new). Reduce excess packaging (drink tap water instead of water from plastic bottles). Recycle materials such as metal cans, old cell phones, and plastic bottles. Purchase products made from recycled materials. Reduce pollution so that resources are maintained. Prevent soil erosion. Plant new trees to replace those that are cut down. Drive cars less, take public transportation, bicycle, or walk. Conserve energy at home (turn out lights when they are not needed). Click image to the left or use the URL below. URL: Click image to the left or use the URL below. URL:", "pos": "From a human point of view, natural resources can be classified as either renewable or nonrenewable. Renewable resources are natural resources that are remade by natural processes as quickly as people use them. Examples of renewable resources include sunlight and wind. They are in no danger of being used up. Metals and some other minerals are considered renewable as well because they are not destroyed when they are used. Instead, they can be recycled and used over and over again. Living things are also renewable resources. They can reproduce to replace themselves. However, living things can be over-used or misused to the point of extinction. For example, over-fishing has caused some of the best fishing spots in the ocean to be nearly depleted, threatening entire fish species with extinction. To be truly renewable, living things must be used wisely. They must be used in a way that meets the needs of the present generation but also preserves them for future generations. Using resources in this way is called sustainable use. Nonrenewable resources are natural resources that cant be remade or else take too long to remake to keep up with human use. Examples of nonrenewable resources are coal, oil, and natural gas, all of which are fossil fuels. Fossil fuels form from the remains of plants and animals over hundreds of millions of years. We are using them up far faster than they can be replaced. At current rates of use, oil and natural gas will be used up in just a few decades, and coal will be used up in a couple of centuries. Uranium is another nonrenewable resource. It is used to produce nuclear power. Uranium is a naturally occurring chemical element that cant be remade. It will run out sooner or later if nuclear energy continues to be used. Soil is a very important natural resource. Plants need soil to grow, and plants are the basis of terrestrial ecosystems. Theoretically, soil can be remade. However, it takes millions of years for soil to form, so from a human point of view, it is a nonrenewable resource. Soil can be misused and eroded (see Figure 25.9). It must be used wisely to preserve it for the future. This means taking steps to avoid soil erosion and contamination of soil by toxins such as oil spills. Some of the resources we depend on the most are energy resources. Whether its powering our lights and computers, heating our homes, or providing energy for cars and other vehicles, its hard to imagine what our lives would be like without a constant supply of energy. Fossil fuels and nuclear energy are nonrenewable energy resources. People worldwide depend far more on these energy sources than any others. Figure 25.10 shows the worldwide consumption of energy sources by type in 2010. Nonrenewable energy sources accounted for 83 percent of the total energy used. Fossil fuels and the uranium needed for nuclear power will soon be used up if we continue to consume them at these rates. Using fossil fuels and nuclear energy creates other problems as well. The burning of fossil fuels releases carbon dioxide into the atmosphere. This is one of the major greenhouse gases causing global climate change. Nuclear power creates another set of problems, including the disposal of radioactive waste. Switching to renewable energy sources solves many of the problems associated with nonrenewable energy. While it may be expensive to develop renewable energy sources, they are clearly the way of the future. Figure 25.11 represents three different renewable energy sources: solar, wind, and biomass energy. The three types are described below. You can watch Bill Nyes introduction to renewable energy resources in this video: MEDIA Click image to the left or use the URL below. URL: Solar energy is energy provided by sunlight. Solar cells can turn sunlight into electricity. The energy in sunlight is virtually limitless and free and creates no pollution to use. Wind energy is energy provided by the blowing wind. Wind turbines, like those in Figure 25.11, can turn wind energy into electricity. The wind blows because of differences in heating of Earths atmosphere by the sun. There will never be a shortage of wind. Biomass energy is energy provided by burning", "neg": "It's time to be water efficient! As populations increase across Australia and the rest of the world, demand for water will also increase. If we don't reduce each individual's demand for water (both directly and through embodied water) the water situation will become dire. It is obvious that we cannot increase demands for water much more without detrimental effects to the environment, society and the economy. It's all too easy to blame someone else for the water situation -\"if 70% of water is used for agriculture then that's what we should target\" - but it's not that easy. We all depend on the food and resources that agriculture provides, and while there are definitely opportunities to increase water efficiency on the farm, the solution will take more than that. We each share responsibility for the sustainable management of our water resources, which means using less water at home, in the workplace, at school, on holidays, on the farm, ... everyone, everywhere, every time. It's time to become water efficient! This involves reassessing our relationship with water, and learning to use it more sparingly. On the most basic level, it requires a behavioural change, and assigning a value to water that truly reflects its worth. We can also unlock economic benefits of being water efficient. There are many real world examples given in the case studies on this site. Everybody has a responsibility to save water, if future generations are to enjoy a similar standard of living to the one we enjoy now. In fact, many of the impacts associated with water use are likely to have an effect on our own lives! www.savewater.com.au has been designed to help you respond to the challenge to become water efficient. It acts as a central repository for relevant information and further advice, so that you can actually achieve significant savings. It also showcases those companies with products that will assist you in your goal.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}237{"query": "Rovering to Success is a book written by Robert Baden-Powell in 1922.", "pos": "Riceyman Steps is a novel by British novelist Arnold Bennett, first published in 1923 and winner of that year's James Tait Black Memorial Prize for fiction.", "neg": "On at least one occasion they succeeded and formed the Kingdom of Kurdistan, which lasted from September 1922 until July 1924.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}238{"query": "C.D. \"Charlie\" Bales, the fire chief of the small American ski town of Nelson, Washington, is intelligent, humorous, charismatic, athletic and skilled. Bales is sensitive about his large nose, which many in town have learned to not mention. He is unable to have it surgically altered because of a dangerous allergy to anesthetics. He is close to many in town, especially his godsister, Dixie, who owns the town diner and several rental homes. He becomes immediately attracted to beautiful newcomer Roxanne Kowalski, an astronomy student renting from Dixie while searching for a new comet. She adores Bales, but only as a friend, preferring Chris, a handsome but dim fireman. Roxanne goes to Bales for help when Chris fails to advance their relationship further than curious glances. Through a turn of events, she falsely believes Chris is deeply intelligent. When Bales informs Chris of Roxanne's interest, Chris gets sick, intimidated by intelligent women. Chris starts to write her a letter, but takes all day with little result. He convinces Bales to write the letter, with prose that soon bowls over Roxanne. When informed that Roxanne wants to meet him, Chris again gets sick and refuses to meet until Bales comes up with a plan to allow him to be as brilliant as his letter makes him appear. Chris arrives at Roxanne's house with a hunter's cap on, hiding the earphones that relay Bales' words. When the equipment fails, Chris bungles the meeting by speaking his own crass thoughts. After Roxanne storms back into the house furious, Chris begs Bales to fix his mess again. At first he repeats what he is told from under a tree beneath Roxanne's window, but soon also ruins that. Then they switch jackets and hats so Bales can speak the words as Chris. They achieve their goal, and she invites Chris in to make love. Roxanne gets word about the comet and has to go out of town for a week. Since she can't find Chris, she gives Bales the address of her hotel and asks him to tell Chris to write to her. Bales writes her several times a day, each letter more incredible than the last. They affect Roxanne so deeply that she returns early. Bales is writing a new letter to her in Dixie's diner when he finds out that Chris (who knows nothing about the letters) is on his way to see Roxanne. He arrives at her home and warns Chris that Roxanne would be mentioning some letters that he supposedly wrote. She tries to get Chris to be the man in the letters, revealing that his looks are only secondary to her. Knowing that his looks are all he has, Chris runs out, leaving her confused. Dixie puts the last letter under her door and after reading it, Roxanne calls Bales over. Chris prepares to leave town with a bartender, Sandy, whom he met while Roxanne was away. When she asks if he has told Roxanne (the women are acquaintances), he replies that he will write her a letter since he has a history of it. Bales arrives, unaware that Roxanne knows the truth. She asks him to read one of the letters and then to look at the back, which shows that Dixie revealed its true author. She explodes in anger that he lied to her. He retorts that he simply wanted to tell her how he felt about her, but she was only interested in Chris's face and body. When he reminds her that it only took a few nice words for Chris to get her into bed, she punches him in the face and throws him out. As he prepares to say more he stops and sniffs the air. He slowly walks back to the firehouse and alerts his team, who then \"follow his nose\" until they find and extinguish the fire. During their celebration afterwards, someone mentions his nose and although everyone thinks he will get upset, he doesn't. Back home, sitting on his roof, Bales hears someone speaking his words to him. It's Roxanne, declaring that she realizes that it was everything from Bales that she loved, not Chris'", "pos": "Ever since the death of their teenage daughter Emily, Doug (James Gandolfini) and Lois (Melissa Leo) Riley have been drifting apart. Because of her grief, Lois has become a cold and distant agoraphobic. Doug begins an affair with Vivian, a younger local waitress. However, Lois manages to maintain her appearance and the presentation of her home despite never leaving and inviting no guests aside from her sister, Harriet. She has even already had headstones put next to their daughter's for them both and made funeral plans. One morning, Doug is informed that Vivian has died, and he travels to New Orleans on a business trip to clear his head. Instead, however, he ends up in a strip club where he meets 16-year-old stripper, Mallory (Kristen Stewart). He politely turns down her offer for a private dance and refuses any sexual contact, but instead accompanies her home and makes an unusual proposition: if Mallory will allow him to stay in her run-down house long enough to straighten himself out, he will pay her $100 a day for her trouble. For Mallory, who isn't used to getting money for doing nothing, it seems like a great deal. She accepts and Doug phones home to tell Lois he won't be coming home for a while. She tells him that she knew about his affair with Vivian but before the conversation can go any further, she hangs up. As time passes, Doug and Mallory settle into an unconventional kind of domesticity, and he becomes more of a father figure for her than anything else including teaching her how to make a bed properly and taking care of her money. Meanwhile, back home, Lois realizes that she'll have to act fast in order to save her marriage, even if that means venturing outside for the first time in nearly a decade. After a couple of attempts, Lois manages to start up her car and get on the freeway heading south. One night, Doug gets a call from Mallory who is in trouble after being robbed of the money she carries around by a client. He goes to pick her up and after arguing about how stupid she's being, he makes her realise that she needs to make some changes before things get worse. The following morning, Lois arrives in town and calls Doug to let him know, who is stunned that she not only left the house but drove all the way instead of flying. He immediately goes to meet her and they embrace one another for the first time in years. On the drive back, he tells her about Mallory (whose real name is Alison) and what she does for a living, which Lois instantly disapproves of. She is shocked to learn how young and foul-mouthed Mallory is. However, like Doug, Lois quickly warms to her due to her striking similarities to Emily. Before long, Lois has also moved in to Mallory's home and the three start to form an unconventional family. Lois helps her out with female problems and takes her shopping to buy suitable underwear, making her feel like a mother again, which she enjoys dearly. But later on when Lois attempts to steer Mallory from the path of self-destruction, the young girl flees. Mallory is then later arrested an altercation with a client, and Doug and Lois rush to be by her side, but shortly after they bail her out, she runs again. In that moment, Doug and Lois realize they cannot use Mallory as a substitute for their daughter and return home to Indianapolis. A few days later, Doug receives a phone call from Mallory in Houston. She looks cleaned up and healthier, and announces her plans about moving to Las Vegas, just before boarding the bus. Doug tells her that he and Lois will always be there for her.", "neg": "In 1982, in New Jersey, Gracie (Mary Ashleigh Green) is in a school playground where one boy is bullying another. She steps in and beats up the bully to help the victim, a boy she likes. But instead of being grateful, he feels humiliated at being rescued \"by a girl,\" and gets angry at her. She promptly punches him in the nose and then sulks alone in the playground. Fast-forward to the present day, and Gracie Hart (Sandra Bullock) is an FBI Special Agent. In the middle of an operation against Russian mobsters, the target starts to choke on some food, and Gracie disobeys her superior's command in order to prevent the target from choking. As a result, a member of her squad gets shot, and she is reprimanded by being reassigned to a desk job. Soon afterwards, the bureau learns that there has been a bomb threat against the 75th annual Miss United States beauty pageant in San Antonio, Texas, which the bureau determines came from the notorious domestic terrorist known as \"The Citizen\". Gracie's partner, Special Agent Eric Matthews (Benjamin Bratt), is chosen to lead the mission to prevent the attack. Despite Eric's position as a lead agent in charge, it is apparent that Gracie is the more capable agent, as Eric is unsure of how to proceed and takes credit for Gracie's suggestions. One of Gracie's suggestions is to put an agent undercover at the pageant. Gracie's male colleagues then proceed to have a bit of fun running the digital images of female and male agents through a website meant for children to play dress up with their dolls. Despite the immature and chauvinistic actions of the agents, Eric recognizes that Gracie is the female FBI agent best qualified for the undercover job. Beauty pageant coach Victor Melling (Michael Caine), whose reputation was ruined after his last contestant criticized his methods, teaches the tomboyish Gracie how to dress, walk, and act like a contestant. She is not used to such behavior, however, and sees the pageant and its participants as \"antifeminist \". Eventually though Victor and Gracie come to respect each other's strengths. Representing New Jersey as \"Gracie Lou Freebush\", Gracie impresses the audience by playing the glass harp and demonstrating self-defense techniques during the talent competition. She also unexpectedly becomes friends with the other contestants, in particular Miss Rhode Island, Cheryl Frasier (Heather Burns) Several suspects emerge, including the corrupt competition director and former pageant winner Kathy Morningside (Candice Bergen); her unpleasant assistant Frank Tobin (Steve Monroe); the veteran pageant MC Stan Fields (William Shatner) who, like Kathy, is being replaced with a younger person; and last but not least Cheryl, who appears to have a history as a radical animal rights activist. While Gracie takes Cheryl and some of the other girls out partying, in an attempt to seek out more information about Cheryl's past through \"girl talk\", The Citizen is arrested elsewhere on an unrelated charge. After hearing what some of the other contestants said about Kathy Morningside's past (she won the pageant only after the original winner \"mysteriously\" contracted food poisoning), Gracie begins to suspect her, and is worried about the safety of the girls. Her boss thinks that her suspicions are groundless and that the pageant is out of danger now that the Citizen has been arrested. He calls off the mission. Gracie opts to turn in her badge and gun and continue the investigation alone. Eric initially fails to support Gracie and is about to return to the bureau when he figures out that Gracie's suspicions must be correct, and returns to help her. In the final round of the pageant, Gracie earns 1st Runner up while Cheryl becomes Miss United States. Gracie realizes that Kathy Morningside and Frank Tobin unknown to anyone (except Victor) is Kathy's son impersonated \"The Citizen\" and made the threat. Because she was going to be fired after the pageant was over, Kathy and her son were planning to murder the newly crowned pageant winner on stage by putting an explosive device in her", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}239{"query": "On 7 July 1899, a part of the territory of Villiers-sur-Marne was detached and merged with a part of the territory of La Queue-en-Brie and a part of the territory of Chennevieres-sur-Marne to create the commune of Le Plessis-Trevise.", "pos": "On 15 December 2015, Andreze, Beaupreau, La Chapelle-du-Genet, Geste, Jallais, La Jubaudiere, Le Pin-en-Mauges, La Poiteviniere, Saint-Philbert-en-Mauges and Villedieu-la-Blouere merged becoming one commune called Beaupreau-en-Mauges.", "neg": "To provide for the Hall of Mirrors as well as the salon de la guerre and the salon de la paix, which connect the grand appartement du roi with the grand appartement de la reine, architect Jules Hardouin Mansart appropriated three rooms from each apartment as well as the terrace that separated the two apartments.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}240{"query": "Fingolfin (IPA: (fiolfin)) is a fictional character in J. R. R. Tolkien's legendarium, appearing in The Silmarillion.", "pos": "Venomm is a fictional character in the Marvel Universe, distinct from the half-alien fictional character known as Venom.", "neg": "In the published version of The Silmarillion, Orodreth (IPA: (orodre)) was an Elf of the First Age, the second son of Finarfin (with Finrod Felagund, Angrod, Aegnor, and Galadriel being his siblings), and a ruler of Nargothrond.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}241{"query": "After a tough loss at home to the Lions, the Eagles traveled down south to New Orleans to take on the Saints in the Mercedes-Benz Superdome. The Saints scored first with Patrick Robinson returning a Michael Vick interception 99 yards for a touchdown and a 7-0 lead for the only score of the game. The Eagles got on the board in the 2nd quarter as Alex Henery kicked a 22-yard field goal to cut the lead to 7-3 not long before Chris Ivory ran for a 22-yard touchdown to move the Saints ahead by 11 with a 14-3 lead and then they would score again with Drew Brees finding Marques Coltson on a 1-yard touchdown pass for a 21-3 halftime lead. The Eagles scored 10 unanswered points in the 3rd quarter with Vick hooking up with DeSean Jackson on a 77-yard touchdown pass for a score of 21-10 and then Henery kicked a 37-yard field goal for a score of 21-13. But the Saints scored one last time as Brees found Jimmy Graham on a 6-yard touchdown pass for a 28-13 lead which would be the final score of the game as neither team scored in the 4th quarter.", "pos": "Coming off their divisional home win over the Panthers, the Falcons flew to Qualcomm Stadium for a Week 13 interconference duel with the San Diego Chargers. In the first quarter, Atlanta took off as kicker Jason Elam got a 35-yard field goal. The Chargers responded with RB LaDainian Tomlinson getting a 3-yard TD run, yet the Falcons stayed close with Elam getting a 40-yard field goal. In the second quarter, Atlanta regained the lead as rookie quarterback Matt Ryan completed an 18-yard TD pass to TE Justin Peelle, along with their defense forcing opposing quarterback Philip Rivers to commit intentional grounding from his own endzone, giving Atlanta a safety. In the third quarter, San Diego answered with safety Eric Weddle returning a fumble 86 yards for a touchdown (with a failed two-point conversion). In the fourth quarter, the Falcons replied with Ryan completing a 5-yard TD pass to rookie WR Harry Douglas. The Chargers tried to come back, as kicker Nate Kaeding nailed a 28-yard field goal. Atlanta's defense stiffened for the victory.", "neg": "Tampa Bay won their second straight game, this one against a team that was highly favored to win. Jameis Winston threw for over 300 yards while Mike Evans received for over 100 yards. The offense was efficient, especially on third down where they went 11 of 15. The defense came up big as well, with safety Chris Conte getting an interception in the end zone, his second straight game with a pick. Rookie kicker Roberto Aguyao, who has struggled throughout the season, went 5/5 on kicks, making 4 field goals and 1 extra point. With this win, the Bucs got back to .500, took sole possession of second place in the NFC South, and improved their road record to 4-1.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}242{"query": "The Battle of Milne Bay (25 August -- 7 September 1942), also known as Operation RE by the Japanese, was a battle of the Pacific campaign of World War II. Elite Japanese naval troops, known as Kaigun Rikusentai (Special Naval Landing Forces), with tank support attacked the Allied airfields at Milne Bay that had been established on the eastern tip of New Guinea.", "pos": "The Battle of Weihaiwei (Japanese: Ikaiei-no-tatakai () was a battle of the First Sino-Japanese War. It took place between 20 January and 12 February 1895 in Weihai, Shandong Province, China between the forces of the Empire of Japan and Empire of China.", "neg": "At the start of World War II, the 24th Infantry was stationed at Fort Benning as school troops for the Infantry School. They participated in the Carolina Maneuvers of October - December 1941. During World War II, the 24th Infantry fought in the South Pacific Theatre as a separate regiment. Deploying on 4 April 1942 from the San Francisco Port of Embarkation, the regiment arrived in the New Hebrides Islands on 4 May 1942. The 24th moved to Guadalcanal on 28 August 1943, and was assigned to the XIV Corps. 1st Battalion deployed to Bougainville, attached to the 37th Infantry Division, from March to May 1944 for perimeter defense duty. The regiment departed Guadalcanal on 8 December 1944, and landed on Saipan and Tinian on 19 December 1944 for Garrison Duty that included mopping up the remaining Japanese forces that had yet to surrender. The regiment was assigned to the Pacific Ocean Area Command on 15 March 1945, and then to the Central Pacific Base Command on 15 May 1945, and to the Western pacific Base Command on 22 June 1945. The regiment departed Saipan and Tinian on 9 July 1945, and arrived on the Kerama Islands off Okinawa on 29 July 1945. At the end of the war, the 24th took the surrender of forces on the island of Aka-shima, the first formal surrender of a Japanese Imperial Army garrison. The regiment remained on Okinawa through 1946.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}243{"query": "Webb Garwood (Van Heflin), a disgruntled cop, is called to investigate a voyeur by Susan Gilvray (Evelyn Keyes). Her husband works nights as an overnight radio personality. Webb falls in love with the young and attractive married woman. Obsessed, he woos her despite her initial reluctance and the two begin an adulterous affair. Webb finds out about an insurance policy on the husband's life. He dreams up a scheme in which a phantom \"prowler\" would be a good scapegoat if Susan's husband should happen to die mysteriously. After becoming a prowler himself, Webb \"investigates\" and then commits the murder, making it look like a tragic accident with he and the husband shooting at each other as each suspected the other of being the prowler. Webb's ruse fools a coroner's jury, thanks in part to both Susan and Webb testifying that they didn't know each other prior to her husband's death. Susan initially suspects Webb of foul play, but becomes convinced of his innocence and subsequently marries him. Shortly after the wedding, Susan informs Webb that she has been pregnant for four months. This is problematic because the date of the child's conception would prove the two had lied in their testimony to cover up their previous relationship, and would thus suggest that Webb's killing of Susan's husband had not been an accident. The two run away to a ghost town named Calico to have the baby without anyone back home knowing. Susan goes into premature labor and Webb finds a doctor, Dr. William James (Wheaton Chambers). Susan realizes that Webb intends to kill Dr. James to preserve their secret, so she warns the doctor who then escapes with the newborn. Susan tells Webb that she knows what he had planned to do and that she now realizes that he intentionally murdered her husband. Realizing the doctor will send the police after him, Webb drives away, leaving his wife in Calico alone. On the way out of town, he find the road blocked by his former partner on the police force who was coming to pay a visit. While attempting to get around his friend's car, Webb sees several police cars coming so he heads for the hills on foot. He refuses to stop and a sheriff's deputy shoots him dead.", "pos": "The film tells the story of a psychiatrist, Dr. Cross (Vincent Price), who is treating a young woman, Janet Stewart (Anabel Shaw), who is in a coma-state, brought on when she heard loud arguing, went to her window and saw a man strike his wife with a candlestick and kill her. It also stars Lynn Bari as Dr. Cross's nurse/lover, Elaine Jordan. As Stewart comes out of her shock, she recognizes Dr. Cross as the killer. He then takes her to his sanitarium and at Elaine's urging, gives Janet an overdose of insulin under the pretense of administering insulin shock therapy. He can't bring himself to murder her in cold blood, though, and asks Elaine to get the medicine to save her. Elaine refuses, they argue, and he strangles her. A colleague of Dr. Cross, Dr. Harvey, saves Janet's life and Dr. Cross is taken into custody by a lawyer from the District Attorney's office.", "neg": "Gas station attendant Clint Ramsey, who works at Martin Bormann's Super Service in the desert, finds himself too irresistible to a series of girls, all of whom have the word \"Super\" in their given names. In the beginning, he is married to the hypersexual, demanding, and jealous SuperAngel (Shari Eubank), who constantly harasses him at work. She orders him home at once when she calls Clint and overhears a female customer, SuperLorna (Christy Hartburg), hitting on him at work. Clint finds SuperAngel's constant accusations and arguing a turnoff and, back at home, they fight after he rejects her aggressive advances. A neighbor calls the police as Clint leaves for a local bar, where the bartender is the very scantily clad SuperHaji (Haji). Meanwhile, SuperAngel seduces Harry Sledge (Charles Napier), the cop who responded to the police call. He is impotent and unable to perform. She repeatedly taunts and insults him over this, which finally results in him killing her by stomping her brutally in a bathtub, then throwing a radio in the water which was plugged into the wall socket. Sledge burns down the house, then tries to pin the murder on Clint. Clint claims being in the pub all night, but SuperHaji has her revenge on him (from insulting her breast size earlier) by refusing to confirm his alibi. Clint is then forced to flee. In his rush to escape, Clint hitchhikes a ride from a boy (John LaZar) and his girlfriend SuperCherry (Colleen Brennan). During the drive, SuperCherry comes on to him and puts his hand over her breast, but then pulls it back. She then tries to give him a handjob over his pants, but he continues to resist her advances. The driver takes offense to Clint rejecting his girlfriend, but she says he probably just wants a closer contact. She again attempts and fails to seduce him and he asks the driver to let him get out. The driver follows him out and beats and robs him. Clint is found by an old farmer who takes him to his farm to heal from his injuries and Clint agrees to work for the farmer for a week to repay him. The farmer has a younger Austrian mail-order bride, SuperSoul (Uschi Digard), who is hypersexual. After energetically satisfying her husband, she comes knocking on Clint's door at night. She immediately pushes him into his bed where she proceeds to mount and rape him, until he manages to overpower her. However, she does the same the following day and this time overpowering him after jumping him from behind in the barn. Looking for SuperSoul, the farmer finds them in the barn, then chases Clint away and punches SuperSoul. Fleeing from the farm, Clint meets a motel owner and his deaf daughter, SuperEula (Deborah McGuire), who convinces him to take a ride with her in her dune buggy to have sex in the desert. They are caught by her father and chased out of town. Clint eventually meets up with SuperVixen (also played by Shari Eubank) at Supervixen's Oasis, a roadside diner. SuperVixen is (inexplicably) a friendly and giving reincarnation of SuperAngel, whose ghost now appears nude between scenes to comment on the plot from atop a bedspring balanced on a mesa. Clint and SuperVixen fall in love and are inseparable, although their common nemesis, Harry Sledge, arrives on the scene and plots ending the lives of the now happy couple.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}244{"query": "The Linth (pronounced (lnt) ''lint'') is a Swiss river that rises near the village of Linthal in the mountains of the canton of Glarus, and eventually flows into the Obersee section of Lake Zurich.", "pos": "The Lambro (Western Lombard: Lamber or Lambar) is a river of Lombardy, northern Italy, a left tributary of the Po.", "neg": "The Paraul Malurilor is a tributary of the Dragan River in Romania.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}245{"query": "Sipho Sibiya Riopel (also known as Siphos Sibya) is a retired South African-Canadian soccer player who is an assistant coach with the Vancouver Whitecaps women's team.", "pos": "Sami Mubarak Faraj Ba Owain commonly known as Sami Mubarak (Arabic: ; born 12 November 1991) is an Omani footballer who plays for Dhofar S.C.S.C. in the Oman Professional League.", "neg": "Yana De Leeuw (born 6 September 1990) is a Belgian female former volleyball player, playing as a setter.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}246{"query": "One of the biggest new bands in the UK is Arctic Monkeys.Their first two singles went straight to Number One in the charts and their first album \"Whatever People Say I Am,That's what I'm No\" has become a recordbreaking album.It's the fastest selling debut album in UK chart history. Arctic Monkeys are famous because of their great success.They achieved their success thanks to the Internet.Usually a new band signs to a record company and then it is through marketing that people buy their singles.The single sales then get the band into the charts and they become popular that way. However,Arctic Monkeys became wellknown in a slightly different way.Back in 2003 when the band first started,they handed out CDs at their performing concert.Certain fans liked the music so much that they put the music up on the Web.The general public had access to this music because it was on the Internet and,because people liked the music,the band's popularity increased.The band's popularity was starting to get noticed by major radio stations in the UK. Arctic Monkeys released their first single in October 2005.Before that,their music had only been available to download on the Internet.When they did finally release a single and an album,they both rose to the top of the charts. Music fans welcome the use of the Internet this way--Arctic Monkeys became popular simply because people liked their music when they heard it.There were no ads.As music downloads continue to increase in popularity,we can expect to see more and more bands make it big in this way.", "pos": "Michael Jackson is one of the world's best singers. Michael Jackson was born in the middle west of the city of Gary, Indiana, in 1958. He began singing with his four brothers. They called the group \"The Jackson Five\". The group became very popular after appearing on a television program. They started singing in 1965, and became popular soon. In 1970 the group made their first record with the name of \"I Want You Back\". It was very popular. One of their hit records was \"Never Say Goodbye\". Michael was good at dancing as well as singing, such as his dance moves and moon walking. He was asked to act in a film in 1978 for the first time, and in the same year he made a record on his own, which sold eight million _ all over the world. Michael nearly didn't go out because he was too famous. Once his fans went off in a faint when they saw him at the concert. No one can do it by now. He lived in a large house and kept lots of animals. He never ate meat. He often raised money for Charity. This made him win the Guinness World Records in 2006. He died on June 25th, 2009, but he would live in our heart forever.", "neg": "Do you prefer British English or American English? Here are opinions from our readers. Andy: Well, being in British for 3 years now from New Zealand I've come to realize that a lot of British people pronounce words how Americans do. But in saying that, I guess the more educated British people do not pronounce words the way some Americans do. So, I prefer Educated British English. Bill: Well, I am studying English and I think British sounds funny and I prefer Americans sounds. Although I can tell that everyone else in my class loves British pronunciation and thinks American English is less pretty or even ugly. I don't agree at all, though. Cindy: At first British English accent sounds better and wonderful but then it gets annoying, so I love American English. Dale: I prefer the British accent. It sounds like someone reading a poem. I just like the pronunciation of the British people, very clear and sounds like music! British accent is more musical. Edward: When I listen to the BBC announcers, I notice that they're exploding the letters out, not pronouncing them. And some British people from the North of England or Scotland speak with strange accents. I mean it is difficult to understand their English. Frank: As a matter of fact, English for International Communication is very much like American accent. I love the American accent.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}247{"query": "A rocket is propelled into space by particles flying out of one end at high speed (see Figure 1.1). A rocket in space moves like a skater holding the fire extinguisher. Fuel is ignited in a chamber, which causes an explosion of gases. The explosion creates pressure that forces the gases out of the rocket. As these gases rush out the end, the rocket moves in the opposite direction, as predicted by Newtons Third Law of Motion. The reaction force of the gases on the rocket pushes the rocket forward. The force pushing the rocket is called thrust. Nothing would get into space without being thrust upward by a rocket. One of the first uses of rockets in space was to launch satellites. A satellite is an object that orbits a larger object. An orbit is a circular or elliptical path around an object. The Moon was Earths first satellite, but now many human- made \"artificial satellites\" orbit the planet. Thousands of artificial satellites have been put into orbit around Earth (Figure 1.2). We have even put satellites into orbit around the Moon, the Sun, Venus, Mars, Jupiter, and Saturn. There are four main types of satellites. Imaging satellites take pictures of Earths surface for military or scientific purposes. Imaging satellites study the Moon and other planets. Communications satellites receive and send signals for telephone, television, or other types of communica- tions. Navigational satellites are used for navigation systems, such as the Global Positioning System (GPS). The International Space Station, the largest artificial satellite, is designed for humans to live in space while conducting scientific research. Humans have a presence in space at the International Space Station (ISS) (pictured in Figure 1.3). Modern space stations are constructed piece by piece to create a modular system. The primary purpose of the ISS is scientific research, especially in medicine, biology, and physics. Craft designed for human spaceflight, like the Apollo missions, were very successful, but were also very expensive, could not carry much cargo, and could be used only once. To outfit the ISS, NASA needed a space vehicle that was reusable and able to carry large pieces of equipment, such as satellites, space telescopes, or sections of a space station. The resulting spacecraft was a space shuttle, shown in (Figure 1.4). Satellites operate with solar panels for energy. A photograph of the International Space Station was taken from the space shuttle Atlantis in June 2007. Construction of the station was completed in 2011, but new pieces and experiments continue to be added. A space shuttle has three main parts. The part you are probably most familiar with is the orbiter, with wings like an airplane. When a space shuttle launches, the orbiter is attached to a huge fuel tank that contains liquid fuel. On the sides of the fuel tank are two large \"booster rockets.\" All of this is needed to get the orbiter out of Earths atmosphere. Once in space, the orbiter can be used to release equipment (such as a satellite or supplies for the International Space Station), to repair existing equipment such as the Hubble Space Telescope, or to do experiments directly on board the orbiter. When the mission is complete, the orbiter re-enters Earths atmosphere and flies back to Earth more like a glider than an airplane. The Space Shuttle program did 135 missions between 1981 and 2011, when the remaining shuttles were retired. The ISS is now serviced by Russian Soyuz spacecraft. Atlantis on the launch pad in 2006. Since 1981, the space shuttle has been the United States primary vehicle for carrying people and large equipment into space.", "pos": "Humans did not reach space until the second half of the 20th century. They needed somehow to break past Earths gravity. A rocket moves rapidly in one direction. The device is propelled by particles flying out of it at high speed in the other direction. There are records of the Chinese using rockets in war against the Mongols as early as the 13th century. The Mongols then used rockets to attack Eastern Europe. Early rockets were also used to launch fireworks. Rockets were used for centuries before anyone could explain how they worked. The theory came about in 1687. Isaac Newton (16431727) described three basic laws of motion, now referred to as Newtons Laws of Motion: 1. An object in motion will remain in motion unless acted upon by a force. 2. Force equals mass multiplied by acceleration. 3. To every action, there is an equal and opposite reaction. Which of these three best explains how a rocket works? Newtons third law of motion. When a rockets propulsion pushes in one direction, the rocket moves in the opposite direction, as seen in the Figure 23.12. For a long time, many people believed that a rocket wouldnt work in space. There would be nothing for the rocket to push against. But they do work! Fuel is ignited in a chamber. The gases in the chamber explode. The explosion creates pressure that forces the gases out of one side of the rocket. The rocket moves in the opposite direction, as shown in Figure 23.13. The force pushing the rocket is called thrust. For centuries, rockets were powered by gunpowder or other solid fuels. These rockets could travel only short distances. Around the turn of the 20th century, several breakthroughs took place. These breakthroughs led to rockets that could travel beyond Earth. Liquid fuel gave rockets enough power to escape Earths gravity (Figure 23.14). By using multiple stages, empty fuel containers could drop away. This reduced the mass of the rocket so that it could fly higher. Rockets were used during World War II. The V2 was the first human-made object to travel high enough to be considered in space (Figure 23.15). Its altitude was 176 km (109 miles) above Earths surface. Wernher von Braun was a German rocket scientist. After he fled Germany in WWII, he helped the United States develop missile weapons. After the war, von Braun worked for NASA. He designed the Saturn V rocket (Figure One of the first uses of rockets in space was to launch satellites. A satellite is an object that orbits a larger object. An orbit is a circular or elliptical path around an object. Natural objects in orbit are called natural satellites. The Moon is a natural satellite. Human-made objects in orbit are called artificial satellites. There are more and more artificial satellites orbiting Earth all the time. They all get into space using some sort of rocket. Why do satellites stay in orbit? Why dont they crash into Earth due to the planets gravity? Newtons law of universal gravitation describes what happens. Every object in the universe is attracted to every other object. Gravity makes an apple fall to the ground. Gravity also keeps you from floating away into the sky. Gravity holds the Moon in orbit around Earth. It keeps Earth in orbit around the Sun. Newton used an example to explain how gravity makes orbiting possible. Imagine a cannonball launched from a high mountain, as shown in Figure 23.17. If the cannonball is launched at a slow speed, it will fall back to Earth. This is shown as paths (A) and (B). Something different happens if the cannonball is launched at a fast speed. The Earth below curves away at the same rate that the cannonball falls. The cannonball then goes into a circular orbit, as in path (C). If the cannonball is launched even faster, it could go into an elliptical orbit (D). It might even leave Earths gravity and go into space (E). Unfortunately, Newtons idea would not work in real life. A cannonball launched at a fast speed from Mt. Everest would not go into orbit.", "neg": "Our planet was born some billions of years ago. Ever since this planet has developed, it has surprised us human beings. No matter how much we human beings have developed technologically, we cannot ever create this kind of natural planet. The human race can only discover some amazing facts about it. Let us find out what some of them are. On September 13, 1922 El Azizia, a place in Libya, recorded a temperature of 136 degrees Fahrenheit. This was the highest temperature ever measured on the planet Earth. The highest waterfall in the world is Angel Falls in Venezuela, which drops from an amazing height of 3,212 feet. The waterfall drops over the edge of Auyantepui in the Canaima National Park. The gravitational pull of the Earth can be escaped if someone moves at a speed of 6.95 miles per second. At such a speed, one could travel from New York to Philadelphia in just 20 seconds. If the entire water in the world's oceans evaporated, the salt we got from these oceans could cover the entire planet with a 500-foot deep layer of salt. The deepest lake on Earth is Lake Baikal in Russia. Lake Baikal is the largest freshwater lake in the world, containing about 20% of the world's unfrozen surface fresh water. The Andes in South America spreads over 4,525 miles. This is the longest mountain range in the world. Did you know that the biggest valley in the world is the Grand Valley in Mesa County, Colorado and Grand County, Utah? It is about 30 miles (48 km) long and 5 miles (8 km) wide, along the Colorado River. The amazing facts about the earth are too many to be told completely above.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}248{"query": "Pulmonary hypertension (PH) is a progressive disease that is accompanied by a poor prognosis. Pulmonary vasoconstriction is facilitated through multiple pathways and results in increased pulmonary vascular pressure leading to cell proliferation, vascular remodeling, right ventricular hypertrophy/failure, and ultimately death. Until recently, just six medications were approved -all for one subclass of PH. On October 8, 2013, riociguat (Adempas®) became the first medication approved for multiple etiologies of PH. Preclinical studies have demonstrated safety and efficacy with significant clinical trials supporting its advancement into phase IV trials. Although long-term safety and efficacy and place in therapy remain to be established, riociguat presents as an exciting new option for the treatment of PH and potentially has additional indications in the near future.", "pos": "Riociguat (Adempas(®)), a soluble guanylate cyclase stimulator, is a new, first-in-class drug approved for the treatment of patients with chronic thromboembolic pulmonary hypertension (CTEPH) [inoperable or persistent/recurrent following surgery] or pulmonary arterial hypertension (PAH). It has been designated an orphan medicine by the European Medicines Agency and the US FDA. This article reviews the available pharmacological properties of oral riociguat and its clinical efficacy and tolerability in adults with CTEPH or PAH. Riociguat is effective and well tolerated in patients with inoperable CTEPH or persistent/recurrent CTEPH following pulmonary endarterectomy, and in patients with PAH. It has a positive result on exercise capacity and pulmonary haemodynamics, and improves WHO functional class. Most adverse events can be attributed to the vasodilatory mechanism of riociguat; however, there is a potential for serious bleeding and fetal harm, and riociguat use is contraindicated in pregnant patients. Pulmonary endarterectomy remains the first treatment of choice for CTEPH, as it is potentially curative. Head-to-head trials comparing riociguat with the approved phosphodiesterase type 5 inhibitors in patients with PAH would be of value for the placement of riociguat in the management of this disease. Riociguat is a promising addition to the treatment options for patients with CTEPH or PAH.", "neg": "One of the major histopathological hallmarks of Alzheimer's disease (AD) is cerebral deposits of extracellular -amyloid peptides. Preclinical studies have pointed to glucagon-like peptide 1 (GLP-1) receptors as a potential novel target in the treatment of AD. GLP-1 receptor agonists, including exendin-4 and liraglutide, have been shown to promote plaque-lowering and mnemonic effects of in a number of experimental models of AD. Transgenic mouse models carrying genetic mutations of amyloid protein precursor (APP) and presenilin-1 (PS1) are commonly used to assess the pharmacodynamics of potential amyloidosis-lowering and pro-cognitive compounds. In this study, effects of long-term liraglutide treatment were therefore determined in two double APP/PS1 transgenic mouse models of Alzheimer's disease carrying different clinical APP/PS1 mutations, i.e. the 'London' (hAPPLon/PS1A246E) and 'Swedish' mutation variant (hAPPSwe/PS1E9) of APP, with co-expression of distinct PS1 variants. Liraglutide was administered in 5 month-old hAPPLon/PS1A246E mice for 3 months (100 or 500 ng/kg/day, s.c.), or 7 month-old hAPPSwe/PS1E9 mice for 5 months (500 ng/kg/day, s.c.). In both models, regional plaque load was quantified throughout the brain using stereological methods. Vehicle-dosed hAPPSwe/PS1E9 mice exhibited considerably higher cerebral plaque load than hAPPLon/PS1A246E control mice. Compared to vehicle-dosed transgenic controls, liraglutide treatment had no effect on the plaque levels in hAPPLon/PS1A246E and hAPPSwe/PS1E9 mice. In conclusion, long-term liraglutide treatment exhibited no effect on cerebral plaque load in two transgenic mouse models of low- and high-grade amyloidosis, which suggests differential sensitivity to long-term liraglutide treatment in various transgenic mouse models mimicking distinct pathological hallmarks of AD.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}249{"query": "Spleen tyrosine kinase (Syk) is a cytoplasmic tyrosine kinase involved in signalling in many of the cells that drive immune inflammation. The development of small molecules that inhibit Syk kinase may change the way we treat disorders such as rheumatoid arthritis (RA), as well as a range of other inflammatory diseases. Fostamatinib (R-788) is an orally bioavailable small molecule. It is the prodrug of R406, which is a potent Syk inhibitor. Fostamatinib was developed because it has more favourable physiochemical properties. It is rapidly converted to R406 by intestinal enterocytes. It has been evaluated in experimental models of RA, such as collagen-induced arthritis. In these models, fostamatinib suppressed clinical arthritis, bone erosions, pannus formation and synovitis. A phase II programme with fostamatinib has largely been completed. Three key trials have been published, lasting 12-26 weeks and each enrolling 189-457 patients (875 in total). All these trials involved placebo therapy and patients continued to receive methotrexate in addition to active treatment with fostamatinib. The first dose-ranging trial evaluated three treatment doses in RA patients who had not fully responded to methotrexate therapy. The second trial compared two treatment doses in patients who had not responded to methotrexate therapy. The third trial compared a single treatment dose with placebo in patients who had not responded to biological therapy. The primary outcome measure was the number of patients achieving American College of Rheumatology (ACR) 20% (ACR20) responses. Placebo ACR20 response rates in all three trials were similar (35-38%). All three trials involved one treatment arm receiving fostamatinib 100 mg twice daily; ACR20 responses with this active treatment ranged from 38% to 67%. A meta-analysis of ACR responses in these trials, using responses to the highest dose in each trial for comparisons with placebo therapy in a random effects model, showed a borderline benefit with ACR20 responses. There were more significant differences with ACR50 and ACR70 responses. The reason that this meta-analysis was not more strongly positive is that the third trial, which evaluated patients who had failed to respond to biological treatments, gave negative results. Individual ACR response components, such as changes in swollen joint counts, showed significant differences in the first two trials, but there were no definite treatment benefits in the third trial. Overall, the differences were significant in a meta-analysis of all three trials. The most important adverse reactions were diarrhoea, neutropenia and raised ALT levels, which all showed significant excesses with active treatment compared with placebo. Too few patients have been studied for a definitive safety profile to be known. Overall, the results of the phase II trials were sufficiently encouraging for a phase III programme to be initiated. It will be some years before their definitive results are available.", "pos": "Rigel Pharmaceuticals Inc is developing fostamatinib, a prodrug of the spleen tyrosine kinase (Syk) inhibitor R-406, for the potential treatment of autoimmune diseases such as rheumatoid arthritis (RA), idiopathic thrombocytopenic purpura (ITP) and B-cell lymphomas. Syk is a key mediator of Fc and B-cell receptor signaling in inflammatory cells, such as B-cells, mast cells, macrophages and neutrophils. Preclinical studies of R-406 or fostamatinib demonstrated a significant reduction in major inflammatory mediators such as TNFalpha, IL-1, IL-6 and IL-18, leading to reduced inflammation and bone degradation in models of RA. In a phase II clinical trial, fostamatinib treatment effectively improved American College of Rheumatology response rates in patients with RA. Preclinical studies and phase II trials also suggested the potential of using fostamatinib for the treatment of ITP and B-cell lymphomas, by increasing platelet counts and inducing response rates, respectively. Fostamatinib is orally bioavailable and was well tolerated in phase I and II trials, with the most common side effect being gastrointestinal symptoms. At the time of publication, phase II trials for fostamatinib were ongoing in patients with RA, ITP and B-cell lymphomas. The Syk inhibitor appears to be a promising therapeutic for immunological diseases, but further data are required to establish the efficacy and long-term safety of the drug in humans.", "neg": "With the recent introduction of inhibitors of mammalian target of rapamycin (mTOR) in oncology, distinct cutaneous and oral adverse events have been identified. In fact, stomatitis and rash are documented as the most frequent and potentially dose-limiting side effects. Clinically, mTOR inhibitor-associated stomatitis (mIAS) more closely resembles aphthous stomatitis than oral mucositis due to conventional anticancer therapies. While most cases of mIAS are mild to moderate and self-limiting, more severe and persistent mIAS can become a dose-limiting toxicity. Small ulcerations may cause significant pain and mucosal sensitivity may occur in the absence of clinical changes. Use of clinical assessment tools that are primarily driven by ulceration size may underestimate mIAS, and assessment should include patient-reported outcomes. This article provides an up-to-date review of the clinical presentation, terminology, pathogenesis, assessment and management of mIAS and other mTOR inhibitor-associated oral adverse events. In addition, areas of future research are considered.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}250{"query": "The Seahawks began their 2008 campaign on the road against the Buffalo Bills. In the first quarter, Seattle trailed early as Bills RB Marshawn Lynch got a 21-yard TD run. In the second quarter, the Seahawks continued to struggle as WR/PR Roscoe Parrish returned a punt 63 yards for a touchdown. Seattle responded with QB Matt Hasselbeck completing a 20-yard TD pass to WR Nate Burleson. Buffalo closed out the half with kicker Rian Lindell getting a 35-yard and a 38-yard field goal. In the third quarter, the Seahawks replied with kicker Olindo Mare nailing a 45-yard field goal. However, the Bills pulled a trick play on Seattle. Appearing to go for a 32-yard field goal, Buffalo's holder (punter Brian Moorman) instead threw a 19-yard TD pass to DE Ryan Denney. The Bills pulled away with QB Trent Edwards completing a 30-yard TD pass to TE Robert Royal.", "pos": "Coming off a bye week, the Bears battled rival Detroit Lions on Monday Night Football. The team kept the Lions from scoring until the fourth quarter, and forced four takeaways. The first turnover forced was in the first half, when Lance Briggs stripped the ball from Mikel Leshoure, which was recovered by Julius Peppers. The second and third turnovers were forced in the third quarter on Zack Bowman's muffed punt recovery, and Brian Urlacher recovering Joique Bell's fumble. The final turnover occurred when Lions quarterback Matthew Stafford's pass was intercepted by D. J. Moore. The Bears struck first on Jay Cutler's touchdown pass to Brandon Marshall, and Robbie Gould kicked a field goal to increase the first half score to 10-0. During the game, Lions defensive tackle Ndamukong Suh threw Cutler to the ground, injuring his ribs. Cutler was eventually replaced by Jason Campbell for a play, before returning to the game. In the second half, Gould kicked another field goal, and prevented the Lions from scoring until the final 36 seconds of the game, when Stafford threw a 12-yard touchdown pass to Ryan Broyles to narrow the margin to six points, but the Bears sealed the victory by recovering the ensuring onside kick.", "neg": "Coming off huge home wins against the 49ers and Steelers, the Seahawks traveled to Minneapolis to take on the Minnesota Vikings. Despite being without both Marshawn Lynch and Jimmy Graham, the Seahawks dominated the Vikings 38-7. Going into the game, the Vikings were previously 8-3 and leading the NFC North, led the NFL in team rushing yards, and Adrian Peterson was the NFL's leading rusher. The Seahawks defense held Peterson to only 18 yards and the Vikings' offense failed to score (their only points coming on a special-teams kickoff return), while Russell Wilson and the Seattle offense racked up 433 yards, five total touchdowns, and no interceptions.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}251{"query": "Once acquired, Epstein-Barr virus (EBV), a latent virus, remains in the body for what appears to be the lifetime of the human host. Circumstantial data suggest EBV is involved in clinical disease including malignancies far more often than previously recognized. A serologic test for early antigen (EA) is more specific for diagnosing active EBV disease than the monospot or heterophile test. A case study of active Epstein-Barr infection is reported showing persistently elevated early antigen titers prior to and following malignant transformation.", "pos": "Infectious Mononucleosis (IM), a benign lymphoproliferative disease, is the best known clinical syndrome caused by Epstein-Barr Virus (EBV). It usually resolves over a period of weeks or months without sequelae but may occasionally be complicated by a wide variety of neurologic, hematologic, hepatic, respiratory, and psychological complications. In this report we describe a patient with acute hepatitis following EBV-IM in a previously healthy woman. A 26-year-old woman who presented with fever, generalized weakness, nausea, sore throat, yellowing of skin, and a generalized skin rash was admitted to our clinic. Tonsillar enlargement, pharyngeal erythema, palatal petechiae, lymphadenopathy, and jaundice were noted. Significant atypical lymphocytes ( > 10%) were seen on the peripheral blood smear. Liver function tests such as ALT: 303 U/L, AST: 172 U/L, ALP: 193 U/L and total bilirubin: 7.3 mg/dl were elevated. Serological tests for EBV infection were consistent with acute infection (EBV virus capsid antigen was reactive with IgM and IgG antibodies). The Monospot test was also positive. On the seventh day, liver function tests and bilirubin had risen to peak level and platelets were decreased. The patient was managed supportively and her critical condition improved and was finally stabilized. Although the prognosis for IM is very favorable, a variety of acute complications may occur.", "neg": "Exosomes are a subset of extracellular vesicles (EVs) that have important roles in intercellular communication. They contain and carry bioactive molecules within their membranes which are delivered to target cells. Reproducible isolation and enrichment of these exosomes will aid in evaluation of cellular communication. We present an approach that involved the pre-processing of plasma, combined with ultracentrifugation (UC) and size exclusion chromatography (SEC) to isolate EVs and subsequently enrich exosomes. Four variations of this approach (denoted methods I to IV) were compared. Coupling an ultracentrifugation method with size exclusion chromatography (Method II) provided the best yield by nanoparticle tracking analyses (NTA), the presence of the exosomal markers CD63, Flotillin-1 and TSG-101 (immunoblotting) and showed exosome morphology using transmission electron microscopy (TEM). This method provides an efficient way to enrich the exosomes from blood (plasma), which could be potentially employed for clinical diagnostic assessment and therapeutic intervention.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}252{"query": "Einar Billing born 6 October 1871 in Lund, died 17 December 1939 in Vasteras, was a Swedish hymnwriter and theologian.", "pos": "Niclas Muller (born in Langenau, near Ulm, Germany, on 15 November 1809; died in New York City, 14 August 1875) was a German-American poet.", "neg": "Hip, Hip, Hurrah! (Danish: Hip, hip, hurra! Kunstnerfest pa Skagen) is an oil-on-canvas painting from 1888 by Norwegian-Danish painter Peder Severin Kryer.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}253{"query": "Her daughter Ariadne was Empress consort of first Zeno and then Anastasius I. Verina was the maternal grandmother of Leo II.", "pos": "Bertuccio Valiero was the son of Silvestro Valiero and Bianca Priuli.", "neg": "Les Abencerages, ou L'etendard de Grenade (English: The Abencerrages, or The Standard of Granada) is an opera in three acts by Luigi Cherubini with a French libretto by Etienne de Jouy, based on the novel Gonzalve de Cordoue by Jean-Pierre Claris de Florian.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}254{"query": "The nonnucleoside reverse transcriptase inhibitors UC-781 and TMC120-R147681 (Dapivirine) effectively prevented human immunodeficiency virus (HIV) infection in cocultures of monocyte-derived dendritic cells and T cells, representing primary targets in sexual transmission. Both drugs had a favorable therapeutic index. A 24-h treatment with 1,000 nM UC-781 or 100 nM TMC120-R147681 prevented cell-free HIV infection, whereas 10-fold-higher concentrations blocked cell-associated HIV.", "pos": "Heterosexual transmission of human immunodeficiency virus (HIV) remains the major route of infection worldwide; thus, there is an urgent need for additional prevention strategies, particularly strategies that could be controlled by women, such as topical microbicides. Potential microbicide candidates must be both safe and effective. Using cellular and tissue explant models, we have evaluated the activity of the nonnucleoside reverse transcriptase inhibitor (NNRTI) dapivirine as a vaginal microbicide. In tissue compatibility studies, dapivirine was well tolerated by epithelial cells, T cells, macrophages, and cervical tissue explants. Dapivirine demonstrated potent dose-dependent inhibitory effects against a broad panel of HIV type 1 isolates from different clades. Furthermore, dapivirine demonstrated potent activity against a wide range of NNRTI-resistant isolates. In human cervical explant cultures, dapivirine was able not only to inhibit direct infection of mucosal tissue but also to prevent the dissemination of the virus by migratory cells. Activity was retained in the presence of semen or a cervical mucus simulant. Furthermore, dapivirine demonstrated prolonged inhibitory effects: it was able to prevent both localized and disseminated infection for as long as 6 days posttreatment. The prolonged protection observed following pretreatment of genital tissue and the lack of observable toxicity suggest that dapivirine has considerable promise as a potential microbicide candidate.", "neg": "With the recent introduction of inhibitors of mammalian target of rapamycin (mTOR) in oncology, distinct cutaneous and oral adverse events have been identified. In fact, stomatitis and rash are documented as the most frequent and potentially dose-limiting side effects. Clinically, mTOR inhibitor-associated stomatitis (mIAS) more closely resembles aphthous stomatitis than oral mucositis due to conventional anticancer therapies. While most cases of mIAS are mild to moderate and self-limiting, more severe and persistent mIAS can become a dose-limiting toxicity. Small ulcerations may cause significant pain and mucosal sensitivity may occur in the absence of clinical changes. Use of clinical assessment tools that are primarily driven by ulceration size may underestimate mIAS, and assessment should include patient-reported outcomes. This article provides an up-to-date review of the clinical presentation, terminology, pathogenesis, assessment and management of mIAS and other mTOR inhibitor-associated oral adverse events. In addition, areas of future research are considered.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}255{"query": "England has a longstanding problem with youngsters dropping out of training. Almost half of 17-year-olds in some parts of England have dropped out of fulltime education or training. The statistics show 49% in Thurrock and 44% in Salford have dropped out of school or job training. Across England,31%of 17-year-olds are not in education or training. The figures also reveal deep regional divides,with wealthier areas such as Richmon and Harrow recording18% of 17-year-olds out of official education. The statistics confirm England's poor international standing for staying-on rates in education. The Organization for Economic Cooperation and Development considers England's drop-out rates as among the worst among the industrialised countries. Regionally,the statistics show Yorkshire and the Humber have the highest rate of 17-year-olds not in full-time education or work-based training at 35%. Outer London has the highest staying-on rate,with l3%of 17-year-olds having dropped out of official learning. In the east of England this figure stands at 31%and at 29%in the South West. Edward Davey,Liberal Democrat Shadow Education Secretary,said the government \"should be ashamed\"that so many youngsters were dropping out of school. A spokesman for the Department for Education and Skills said the government had carried out a series of reforms,with aPS2.5 billion rise in funding for further education.", "pos": "\"When I grow up, I want to be...\" Almost all of us have thought about, or been asked to think about, our future careers. Our answers may differ greatly. Even now your aspirations may have changed from when you were in primary school. However, it seems career options aren't only based on personal taste. In a survey carried out by Teens, doctors, lawyers, and bankers were some of most popular careers that people said they hoped to follow. This is in line with a similar survey carried out in the UK in May 2011 by job website monster. Co.uk, in which medicine was the top choice among UK teenagers aged between 13 and 17. Medicine and law are two of the oldest and best known professions. Their prestige may come from the fact that doctors and lawyers are some of the most esteemed members of society, and they make good money. Joining these high-profile professions is often seen as a sign of upward social mobility. It is equally unsurprising that banking is now one of the most common career choices. Youngsters worldwide think of banking and see the money rolling in. Wealth is increasingly becoming one of the most important indicators of a successful career. British young men list the UK tycoon Alan Sugar, Microsoft founder Bill Gates and Facebook chief Mark Zuckerberg as their top role models \"for their wealth\". Just as Chinese teenagers see being a banker as a good and fun pathway to \"wealth\". However, not every child has the makings of doctor, lawyer, or banker. They are those who see fulfillment and happiness in other areas, and many teenagers dare to ink more individuality into their career options. As the Teens' survey discovered, a variety of unconventional jobs---coffee shop owner, gourmet ,waiter at a fast food restaurant---are among teenagers' career choices. They can be equally interesting and rewarding jobs. With every choice comes responsibility and challenge, and all career paths require specific education and training, you have to learn to balance optimism and confidence with being realistic about your particular talents and skills.", "neg": "The days of the sneak thief who stole a couple of apples or a packet of sweets from a chain store are actually over. I had a chance to say this to a young offender the other day, \"Sweets from a chain store?\" He said, \"You must be joking. That's what kids do.\" I may add that he was aged 11. In other words, today's young criminals would find it laughable to risk being caught for petty theft of this description. They've got enough money in their pockets to buy the sweets they want, anyway. I think it's all too easy to put the blame on anyone but ourselves. Faced as they are with a society that frequently gives them up on the grounds of color1, race or low learning ability, these children turn to crime as a means of showing off their self-respect. Nurtured on films and TV glamorizing the role of the criminal, they are quick to copy these anti-heroes. It is a matter of increasing concern to the police and government that the Children and Young Persons Act, 1969, is becoming improper to deal with the rise in young criminals. Because the emphasis has been placed on the cause and gentle treatment of their crimes, rather than on old-fashioned methods of punishment, the children themselves know well that there is very little that can be done to prevent them continuing to steal, damage and in some case even cause the death of those they choose to terrorize . I don't like the look of this situation any more than you do. In our own interests and in those of our children and grandchildren, we cannot continue to take the \"it's nothing to do with me\" attitude we have used for so long. We must unite in a common demand for harder and stricter methods against these young criminals.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}256{"query": "Radioactivity is the ability of an atom to emit, or give off, charged particles and energy from the nucleus. The charged particles and energy are called by the general term radiation. Only unstable nuclei emit radiation. When they do, they gain or lose protons. Then the atoms become different elements. (Be careful not to confuse this radiation with electromagnetic radiation, which has to do with the light given off by atoms as they absorb and then emit energy.) Radioactivity was discovered in 1896 by a French physicist named Antoine Henri Becquerel. Becquerel was experimenting with uranium, which glows after being exposed to sunlight. Becquerel wanted to see if the glow was caused by rays of energy, like rays of light and X-rays. He placed a bit of uranium on a photographic plate. The plate was similar to film thats used today to take X-rays. You can see an example of an X-ray in Figure 11.1. As Becquerel predicted, the uranium left an image on the photographic plate. This meant that uranium gives off rays after being exposed to sunlight. Becquerel was a good scientist, so he wanted to repeat his experiment to confirm his results. He placed more uranium on another photographic plate. However, the day had turned cloudy, so he tucked the plate and uranium in a drawer to try again another day. He wasnt expecting the uranium to leave an image on the plate without being exposed to sunlight. To his surprise, there was an image on the plate in the drawer the next day. Becquerel had discovered that uranium gives off rays without getting energy from light. He had discovered radioactivity, for which he received a Nobel prize. To learn more about the importance of Becquerels research, go to this URL: [Link] Another scientist, who worked with Becquerel, actually came up with the term \"radioactivity.\" The other scientist was the French chemist Marie Curie. She went on to discover the radioactive elements polonium and radium. She won two Nobel Prizes for her discoveries. You can learn more about Marie Curie at this URL: [Link] Isotopes are atoms of the same element that differ from each other because they have different numbers of neutrons. Many elements have one or more isotopes that are radioactive. Radioactive isotopes are called radioisotopes. An example of a radioisotope is carbon-14. All carbon atoms have 6 protons, and most have 6 neutrons. These carbon atoms are called carbon-12, where 12 is the mass number (6 protons + 6 neutrons). A tiny percentage of carbon atoms have 8 neutrons instead of the usual 6. These atoms are called carbon-14 (6 protons + 8 neutrons). The nuclei of carbon-14 are unstable because they have too many neutrons. To be stable, a small nucleus like carbon, with just 6 protons, must have a 1:1 ratio of protons to neutrons. In other words, it must have the same number of neutrons as protons. In a large nucleus, with many protons, the ratio must be 2:1 or even 3:1 protons to neutrons. In elements with more than 83 protons, all the isotopes are radioactive (see Figure 11.2). The force of repulsion among all those protons overcomes the strong force holding them together. This makes the nuclei unstable and radioactive. Elements with more than 92 protons have such unstable nuclei that these elements do not even exist in nature. They exist only if they are created in a lab. A low level of radiation occurs naturally in the environment. This is called background radiation. It comes from various sources. One source is rocks, which may contain small amounts of radioactive elements such as uranium. Another source is cosmic rays. These are charged particles that arrive on Earth from outer space. Background radiation is generally considered to be safe for living things. A source of radiation that may be more dangerous is radon. Radon is a radioactive gas that forms in rocks underground. It can seep into basements and get trapped inside buildings. Then it may build up and become harmful to people who breathe it. Other sources of radiation are described in the interactive animation at this URL: [Link] You may have seen a sign like", "pos": "Radioactive decay is the process in which the nuclei of radioactive atoms emit charged particles and energy, which are called by the general term radiation. Radioactive atoms have unstable nuclei, and when the nuclei emit radiation, they become more stable. Radioactive decay is a nuclearrather than chemicalreaction because it involves only the nuclei of atoms. In a nuclear reaction, one element may change into another. Click image to the left or use the URL below. URL: There are several types of radioactive decay, including alpha, beta, and gamma decay. In all three types, nuclei emit radiation, but the nature of the radiation differs. The Table 1.1 shows the radiation emitted in each type of decay. Type Alpha decay Beta decay Gamma decay Radiation Emitted alpha particle (2 protons and 2 neutrons) + energy beta particle (1 electron or 1 positron) + energy energy (gamma ray) Both alpha and beta decay change the number of protons in an atoms nucleus, thereby changing the atom to a different element. In alpha decay, the nucleus loses two protons. In beta decay, the nucleus either loses a proton or gains a proton. In gamma decay, no change in proton number occurs, so the atom does not become a different element. Q: If the radioactive element polonium (Po) undergoes alpha decay, what element does it become? A: From the periodic table, the atomic number of polonium is 84, so it has 84 protons. If it loses two protons through alpha decay, it will have 82 protons. Atoms with 82 protons are the element lead (Pb). The charged particles and energy emitted during radioactive decay can harm living things, but the three types of radioactive decay arent equally dangerous. Thats because they differ in how far they can travel and what they can penetrate. You can see this in the Figure 1.1.", "neg": "Eugene-Melchior Peligot (24 March 1811, Paris -- 15 April 1890, Paris), also known as Eugene Peligot, was a French chemist who isolated the first sample of uranium metal in 1841.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}257{"query": "Gene expression signatures can provide an unbiased view into the molecular changes underlying biologically and medically interesting phenotypes. We therefore initiated this study to identify signatures that would be of utility in studying rheumatoid arthritis (RA). We used microarray profiling of peripheral blood mononuclear cells (PBMCs) in 30 RA patients to assess the effect of different biologic agent (biologics) treatments and to quantify the degree of a type-I interferon (IFN) signature in these patients. A numeric score was derived for the quantification step and applied to patients with RA. To further characterize the IFN response in our cohort, we employed type-I IFN treatment of PBMCs in vitro and in reporter assays. Profiling identified a subset of RA patients with upregulation of type-I IFN-regulated transcripts, thereby corroborating previous reports showing RA to be heterogeneous for an IFN component. A comparison of individuals currently untreated with a biologic with those treated with infliximab, tocilizumab, or abatacept suggested that each biologic induces a specific gene signature in PBMCs. It is possible to observe signs of type-I IFN pathway activation in a subset of clinically active RA patients without C-reactive protein elevation. Furthermore, biologics-specific gene signatures in patients with RA indicate that looking for a biologic-specific response pattern may be a potential future tool for predicting individual patient response.", "pos": "To validate the presence and demonstrate the clinical value of the type I interferon (IFN)-signature during arthritis development. In 115 seropositive arthralgia patients who were followed for the development of arthritis (Amsterdam Reade cohort), and 25 presymptomatic individuals who developed rheumatoid arthritis (RA) later, and 45 population-based controls (Northern Sweden cohort), the expression levels of 7 type I IFN response genes were determined with multiplex qPCR and an IFN-score was calculated. The diagnostic performance of the IFN-score was evaluated using Cox regression and Receiver Operating Characteristics (ROC)-curve analysis. In 44 of the 115 at-risk individuals (38%) from the Amsterdam Reade cohort, arthritis developed after a median period of 8 months (IQR 5-13). Stratification of these individuals based on the IFN-score revealed that 15 out of 25 IFN(high) individuals converted to arthritis, compared with 29 out of 90 IFN(low) individuals (p=0.011). In the Northern Sweden cohort, the level of the IFN-score was also significantly increased in presymptomatic individuals who developed RA compared with population-based controls (p=0.002). Cox regression analysis of the Amsterdam Reade cohort showed that the hazard ratio (HR) for development of arthritis was 2.38 (p=0.008) for IFN(high) at-risk individuals after correction for anticitrullinated protein antibodies (ACPA) and rheumatoid factor (RF). The ROC-curve area under the curve (AUC) for the IFN-score combined with ACPA and RF in the prediction of arthritis was 78.5% (p=0.0001, 95% CI 0.70 to 0.87). The results demonstrated clinical utility for the IFN-signature as a biomarker in the prediction of arthritis development.", "neg": "Increased expression of nerve growth factor in injured or inflamed tissue is associated with increased pain. This proof-of-concept study was designed to investigate the safety and analgesic efficacy of tanezumab, a humanized monoclonal antibody that binds and inhibits nerve growth factor. We randomly assigned 450 patients with osteoarthritis of the knee to receive tanezumab (administered at a dose of 10, 25, 50, 100, or 200 g per kilogram of body weight) or placebo on days 1 and 56. The primary efficacy measures were knee pain while walking and the patient's global assessment of response to therapy. We also assessed pain, stiffness, and physical function using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC); the rate of response using the criteria of the Outcome Measures for Rheumatology Committee and Osteoarthritis Research Society International Standing Committee for Clinical Trials Response Criteria Initiative (OMERACT-OARSI); and safety. When averaged over weeks 1 through 16, the mean reductions from baseline in knee pain while walking ranged from 45 to 62% with various doses of tanezumab, as compared with 22% with placebo (P<0.001). Tanezumab, as compared with placebo, was also associated with significantly greater improvements in the response to therapy as assessed with the use of the patients' global assessment measure (mean increases in score of 29 to 47% with various doses of tanezumab, as compared with 19% with placebo; P0.001). The rate of response according to the OMERACT-OARSI criteria ranged from 74 to 93% with tanezumab treatment, as compared with 44% with placebo (P<0.001). The rates of adverse events were 68% and 55% in the tanezumab and placebo groups, respectively. The most common adverse events among tanezumab-treated patients were headache (9% of the patients), upper respiratory tract infection (7%), and paresthesia (7%). In this proof-of-concept study, treatment with tanezumab was associated with a reduction in joint pain and improvement in function, with mild and moderate adverse events, among patients with moderate-to-severe osteoarthritis of the knee. (Funded by Rinat Neuroscience; ClinicalTrials.gov number, NCT00394563.).", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}258{"query": "News @ 6 is the flagship evening newscast of People's Television Network in the Philippines, succeeding newscast Teledyaryo.", "pos": "CBSN is an internet television news channel operated by the CBS News and CBS Interactive divisions of CBS Corporation which launched on November 6, 2014.", "neg": "Astro Awani is the in-house rolling television news and current affairs channel providing 24-hour news coverage including news in Malay.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}259{"query": "Bright, Spacious Room Spacious, single furnished room in owner- occupied home is available now, for one and a half years. Ground floor flat. Five-minute walk to the town center and local bus services. Well-equipped shared kitchen, including washing machine. Shared shower& toilet. Large rooms, with high ceilings, a warm and pleasant home. Responsible for own food & cooking, washing, telephone, insurance, etc. No smoking or pets. Not suitable for children. WiFi available locally. Call Jenna on 85756624 if you are interested. One Bedroom Newly Refurbished Flat in Burnage A fantastic one-bedroom flat in the heart of Burnage is available for however long you want. The property has just been refurbished to a high standard. Situated above the pharmacy on Burnage Lane the property boasts a kitchen, large lounge, separate shower and toilet, and bedroom with in- built wardrobes. A must-see! Call Daniel on 70554323 at the weekend. Two Bedrooms Left in Four-bed House Share A great four- bedroom property in the heart of Fallowfield. Two Bedrooms left in a mixed student house. The property has a dining area, toilet, lounge and one bedroom on the ground floor, followed by three bedrooms on the first floor with an extra toilet. Very close to the main bus stop & local amenities : supermarket, Lloyds pharmacy and local launderette. Two minutes' walking distance to the centre of Fallowfield. The property is available from the 1 of July 2012 to 30 June 2013. Half rent for July/ Aug. We are a private landlord; so there are no agency fees! Jack welcomes you to call. Phone:22604322. Board and Lodgings Close to Boston, Lincolnshire We have a double room available on a board and lodgings basis from 1 of June, 2012 to 1 of May, 2013. Within a comfortable, peaceful farmhouse, set in lovely gardens and beautiful countryside. Share a bathroom with one other person only. Room has own TV with Freeview and access to wireless broadband,. Use of the garden and rest of the house. On the bus route to Boston and Horncastle. Free car parking space. All meals, bills, etc. included. Can cater for a variety of special dietary needs if required, Please call Alice at the weekend or after 7p.m. On workdays. Phone:42556755.", "pos": "This busy and popular hotel requires a Junior Chef. You will need to be energetic, enthusiastic with a minimum of five years' kitchen experience. You must assist the head and senior chefs in the creation of new dishes. Annual salaries range from 20,000 to 25,000 pounds. Please send or e-mail your CV to the Personnel Administrator Hydo Hotel, Mount Road Eastbourne BN207HZ eclaine.ward@hydrohotel.com. We are looking for a kitchen assistant willing to learn the day-to-day jobs in a professional kitchen environment. You must have a passion for cooking and basic understanding of spoken English. You will mainly be working for a well-known company and learn valuable cheffing skills. The salary will be based on experience but could start from 12,500 pounds to 14,000 pounds annually plus tips. Please forward your CV and a letter of recommendation. 01428644460 Kitchen Manager. Spirit Pub Company is looking for the best individuals to lead our kitchen teams through some very exciting new developments. As an experienced Kitchen Manager, you will play an important role in engaging the chef team by great leaderships to deliver excellent standards and guest satisfaction. We can offer a starting salary of up to 27,000 pounds plus a bonus worth an extra 2,000 pounds per year for the right candidates. If you have what it takes to join our company, please provide your CV with your application. 07044338313 Food Service Assistant, South East Food Service Assistant required. Salary starts from 15,000 pound to 20,000 pounds annually. We are seeking a General Assistant for a Care Home East Sussex. Assisting the Cook and kitchen team in the food preparation of freshly prepared meals, washing up and cleaning of all kitchen areas. Previous experience would be an advantage. 07044338228", "neg": "While I was waiting to enter university,I saw advertised in a local newspaper a teaching post at a school in a suburb of London about ten miles from where I lived. Being very short of money, I applied. Three days later, a letter arrived, asking me to go to Croydon for an interview. It proved a tiring journey: a train to Croydon station; a ten-minute bus ride and then a walk of at least fifteen minutes. It was clearly the headmaster himself that opened the door. He was short and fat, with a grey-color1ed moustache,a deeply lined face and hardly any hair. He looked at me with surprised disapproval. Then he said. \"You'd better come inside.\" Leading me into his study, he started to ask me a number of questions: what subjects I had taken in my General School Certificate;how old I was; what games I played; whether I thought games were an important part of a boy's education, etc. I said something about not attaching too much importance to them. We obviously had very little in common. The teaching arrangement filled me with fear. I was to divide the class of twenty-four boys, aged from seven to thirteen, into three groups and teach them all subjects--including art, football, cricket and so on--in turn at three different levels. Actually, I was depressed at the thought of teaching algebra and geometry--two subjects in which I had been rather weak at school. I said shyly, \"What would my salary be?\" \"Twelve pounds a week plus lunch.\" Before I could speak, he got to his feet. \"Now,\" he said, \"you'd better meet my wife. She's the one who really runs this school.\" This was the last thing I could hear. I was young. How could my dignity allow me to work under an old woman?", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}260{"query": "Hill+Knowlton Strategies is a global public relations company, headquartered in New York City, United States, with 90 offices in 52 countries.", "pos": "The Kaiser Shipyards were seven major shipbuilding yards located on the U.S. west coast during World War II. Kaiser ranked 20th among United States corporations in the value of wartime production contracts.", "neg": "Monserrate (after Catalan homonym mountain Montserrat) is a mountain that dominates the city center of Bogota, the capital city of Colombia.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}261{"query": "Cocodrilos de Caracas is a Venezuelan professional basketball club.", "pos": "Sven Kaldre (born 31 October 1991) is a professional basketball player who plays as a shooting guard.", "neg": "Monserrate (after Catalan homonym mountain Montserrat) is a mountain that dominates the city center of Bogota, the capital city of Colombia.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}262{"query": "Notre-Dame du Reclus Abbey or Sancta Maria de Recluso Abbey was a male Cistercian monastery near Sezanne in the Epernay arrondissement of the diocese of Troyes.", "pos": "Barbeau Abbey (French: Abbaye de Barbeau or Abbaye Notre-Dame de Barbeau; Latin: Barbelum, Sequanae portus or Sacer portus) is a former Cistercian monastery in Fontaine-le-Port in the Seine-et-Marne department, France.", "neg": "Fotografiska is housed at Stadsgarden, in a former customs house in the Art Nouveau style dating from 1906.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}263{"query": "The terms Baltic region, Baltic Rim countries, and Baltic Rim refer to slightly different combinations of countries in the general area surrounding the Baltic Sea.", "pos": "Originating in Germany, the Danube flows southeast for 2,860 km (1,780 mi), passing through or touching the border of Austria, Slovakia, Hungary, Croatia, Serbia, Romania, Bulgaria, Moldova and Ukraine before emptying into the Black Sea.", "neg": "The IUCN Redlist 3.1, which uses the Birdlife International checklist, lumps the common and widespread grey-headed parrot with Cape parrots and brown-necked parrots, each of which are more narrowly distributed and more threatened, leading to an assessment of least concern.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}264{"query": "Opicapone is a novel third generation catechol-O-methyltransferase (COMT) inhibitor. The purpose of this study was to compare the levodopa pharmacokinetic profile throughout a day driven by the COMT inhibition either following repeated doses of opicapone or concomitant administration with entacapone. A randomized, double-blind, gender-balanced, parallel-group study was performed in 4 groups of 20 healthy subjects each. Four subjects in each group received placebo during the entire study. Sixteen subjects in one group received placebo once daily for 11 days and on day 12, 200 mg entacapone concomitantly with each levodopa/carbidopa dose (three times separated by a 5-h interval). Sixteen subjects in each of the remaining three groups received respectively 25, 50, and 75 mg opicapone once daily for 11 days and on day 12, placebo concomitantly with each levodopa/carbidopa dose. Levodopa minimum plasma concentration (Cmin) for each levodopa/carbidopa dose and for the mean of all levodopa/carbidopa doses increased substantially with all active treatments (entacapone and opicapone) when compared to the control group (placebo), with values ranging from 1.7-fold (200 mg entacapone) to 3.3-fold (75 mg opicapone). No statistical difference was found for levodopa peak of systemic exposure (as assessed by maximum observed plasma concentration (Cmax)) between all active treatments and placebo. A significant increase in the levodopa extent of systemic exposure (as assessed by concentration-time curve (AUC)) occurred with all opicapone treatments in relation to placebo. No statistical difference was found for levodopa AUC when entacapone was compared to placebo. When compared to entacapone, both 50 and 75 mg opicapone presented a significant increase for the levodopa AUC. All active treatments significantly inhibited both peak (as assessed by Emax) and extent (as assessed by effect-time curve (AUEC)) of the COMT activity in relation to placebo. When compared to entacapone, all opicapone treatments significantly decreased the extent (AUEC) of the COMT activity due to a long-lasting and sustained effect. The tolerability profile was favorable for all active treatments. Opicapone, a novel third generation COMT inhibitor, when compared to entacapone, provides a superior response upon the bioavailability of levodopa associated to more pronounced, long-lasting, and sustained COMT inhibition. The tolerability profile was favorable. On the basis of the results presented in this study and along with the earlier pharmacology studies, it is anticipated that opicapone adjunct therapy at the dosages of 25 and 50 mg will provide an enhancement in levodopa availability that will translate into clinical benefit for Parkinson's disease patients.", "pos": "Fostamatinib (R788) is a prodrug rapidly converted to its active metabolite on oral administration. This (known as R406) is a potent inhibitor of spleen tyrosine kinase, required for the expression of a number of proinflammatory cytokines. Fostamatinib has shown significantly superior efficacy (when compared with placebo) in the control of patients with rheumatoid arthritis not responding to methotrexate in Phase II clinical trials. Treatment emergent adverse events with a higher frequency than in those on placebo included diarrhea, hypertension, urinary tract infections, neutropenia and elevated transaminases. The studied doses have shown a linear pharmacokinetic pattern and the administration of methotrexate does not affect it. Fostamatinib may have a role in the therapy of patients with rheumatoid arthritis with poor response to conventional therapy. If these results are confirmed once Phase III studies are completed, it may find a place in the evolving treatment algorithm for rheumatoid arthritis.", "neg": "The objective of this study was to analyze the expression levels of multiple components in the mammalian target of rapamycin (mTOR) signaling pathway in radical nephrectomy specimens from patients with metastatic renal-cell carcinoma (RCC) treated with mTOR inhibitors in order to identify factors predicting susceptibility to these agents. This study retrospectively included a total of 48 consecutive patients undergoing radical nephrectomy, who were diagnosed with metastatic RCC and subsequently treated with an mTOR inhibitor (everolimus or temsirolimus) as either first- or second-line systemic therapy. Expression levels of 5 molecular markers involved in the signaling pathway associated with mTOR, including PTEN, phosphorylated (p)-Akt, p-mTOR, p-p70 ribosomal S6 kinase, and p-4E-binding protein 1 (4E-BP1), were measured by immunohistochemical staining of primary RCC specimens. Of several factors examined, bone metastasis, liver metastasis, and the expression level of p-4E-BP1 were shown to have significant impacts on the response to the mTOR inhibitors. Progression-free survival (PFS) was significantly correlated with the expression levels of PTEN and p-4E-BP1 in addition to the presence of bone metastasis on univariate analysis. Of these significant factors, p-4E-BP1 expression and bone metastasis appeared to be independently associated with PFS on multivariate analysis. These findings suggest that it would be useful to consider the expression levels of potential molecular markers in the mTOR signaling pathway, particularly p-4E-BP1, as well as conventional clinical parameters when selecting patients with metastatic RCC who are likely to benefit from treatment with mTOR inhibitors.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}265{"query": "Zurenborg is an area in south-east Antwerp largely developed between 1894 and 1906 that features a high concentration of townhouses in Art Nouveau and other fin-de-siecle styles.", "pos": "The Witte Huis (Dutch pronunciation: (t ys)) or White House is a building and National Heritage Site in Rotterdam, Netherlands, built in 1898 in the Art Nouveau style.", "neg": "La Pannonie is an old village of the Lot region, between Gramat and Rocamadour, situated since the 19th century in the commune of Couzou.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}266{"query": "Pearl Django is a jazz group established in 1994 in Tacoma, Washington by guitarists Neil Andersson and Dudley Hill, and bassist David ''Pope'' Firman.", "pos": "Apollo 440 (alternately known as Apollo Four Forty or @440) are an English band formed in Liverpool in 1990.", "neg": "Sigma Editions is an independent record label founded in 1998 by Rosy Parlane and Dion Workman (both ex-members of Thela).", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}267{"query": "On July 7, 1981, while being driven from the Chicago area to a speaking engagement near Knox, Indiana, Peace Pilgrim was killed in an automobile accident.", "pos": "Vedat Dalokay died in a traffic accident on March 21, 1991, in which his wife Ayca (age 44) and son Bars (age 17) were also killed.", "neg": "It's eight o'clock and the time for Morning New Highlights . One person was killed and two were injured in a car accident just thirty minutes ago. Cause of the accident is not yet found out. A great fire swept through a storehouse next to the Fulton River early this morning, causing about $3,000,000 in damage. The fire which broke out at about 2:30 was finally put out at 5: 30. That was the Morning News Highlights, Dan Verne reporting.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}268{"query": "Two functions of the female reproductive system are similar to the functions of the male reproductive system: producing gametes and secreting a major sex hormone. In the case of females, however, the gametes are eggs, and they are produced by the ovaries. The hormone is estrogen, which is the main sex hormone in females. Estrogen has two major roles: During adolescence, estrogen causes the changes of puberty. It causes the reproductive organs to mature. It also causes other female traits to develop. For example, it causes the breasts to grow and the hips to widen. During adulthood, estrogen is needed for a woman to release eggs from the ovaries. The female reproductive system has another important function, which is not found in males. It supports a baby as it develops before birth. It also gives birth to the baby at the end of pregnancy. The female reproductive organs include the ovaries, fallopian tubes, uterus, and vagina. These organs are shown in Figure 22.3, along with some other structures of the female reproductive system. Find each organ in the drawing as you read about it below. For a cartoon about the female reproductive system, watch this video: [Link] The two ovaries are small, oval organs on either side of the abdomen. Each ovary contains thousands of eggs. However, the eggs do not develop fully until a female has gone through puberty. Then, about once a month, an egg is released by one of the ovaries. The ovaries also secrete estrogen. The two fallopian tubes are thin tubes that are connected to the uterus and extend almost to the ovaries. The upper end of each fallopian tube has fingers (called fimbriae) that sweep an egg into the fallopian tube when it is released by the ovary. The egg then passes through the fallopian tube to the uterus. If an egg is fertilized, this occurs in the fallopian tube. The uterus is a hollow organ with muscular walls. The uterus is where a baby develops until birth. The walls of the uterus stretch to accommodate the growing fetus. The muscles in the walls contract to push the baby out during birth. The uterus is connected to the vagina by a small opening called the cervix. The vagina is a cylinder-shaped organ that opens to the outside of the body. The other end joins with the uterus. Sperm deposited in the vagina swim up through the cervix, into the uterus, and from there into a When a baby girl is born, her ovaries contain all of the eggs they will ever produce. But these eggs are not fully developed. They develop only after the female reaches puberty at about age 12 or 13. Then, just one egg develops each month until she reaches her 40s or early 50s. Human eggs are very large cells. In fact, they are the largest of all human cells. You can even see an egg without a microscope. Its almost as big as the period at the end of this sentence. Like a sperm cell, an egg cell is a haploid cell with half the number of chromosomes of other cells in the body. Unlike a sperm cell, the egg lacks a tail and contains a lot of cytoplasm. Egg production takes place in the ovaries. It occurs in several steps: 1. Before birth, special cells in the ovaries go through mitosis to make identical daughter cells. 2. The daughter cells then start to divide by meiosis. However, they go though only the first of the two cell divisions of meiosis at this time. They remain in that stage until the girl goes through puberty. 3. After puberty, an egg develops in an ovary about once a month. As you can see in Figure 22.4, the egg rests in a nest of cells called a follicle. The follicle and egg grow larger and go through other changes. 4. After a couple of weeks, the egg bursts out of the follicle and through the wall of the ovary. This is called ovulation. After ovulation occurs, the moving fingers of the nearby fallopian tube sweep the egg into the tube. Fertilization may occur if sperm reach the egg while it is", "pos": "The female reproductive organs include the vagina, uterus, fallopian tubes, and ovaries ( Figure 1.1). The breasts are not shown in this figure. They are not considered reproductive organs, even though they are involved in reproduction. They contain mammary glands that give milk to feed a baby. The milk leaves the breast through the nipple when the baby sucks on it. The vagina is a cylinder-shaped organ found inside of the female body. One end of the vagina opens at the outside of the body. The other end joins with the uterus. During sexual intercourse, sperm may be released into the vagina. If this occurs, the sperm will move through the vagina and into the uterus. During birth, a baby passes from the uterus to the vagina to leave the body. The uterus is a hollow organ with muscular walls. The part that connects the vagina with the uterus is called the cervix. The uterus is where a baby develops until birth. The walls of the uterus grow bigger as the baby grows. The muscular walls of the uterus push the baby out during birth. This drawing shows the organs of the female reproductive system. It shows the organs from the side. Find each organ in the drawing as you read about it in the text. The two ovaries are small, oval organs on either side of the uterus. Each ovary contains thousands of eggs, with about 1-2 million immature eggs present at birth and 40,000 immature eggs present at puberty, as most of the eggs die off. The eggs do not fully develop until a female has gone through puberty. About once a month, on average one egg completes development and is released by the ovary. The ovaries also secrete estrogen, the main female sex hormone. The two fallopian tubes are narrow tubes that open off from the uterus. Each tube reaches for one of the ovaries, but the tubes are not attached to the ovaries. The end of each fallopian tube by the ovary has fingers ( Figure 1.1). They sweep an egg into the fallopian tube. Then the egg passes through the fallopian tube to the uterus. If an egg is to be fertilized, this will occur in the fallopian tube. A fertilized egg then implants into the wall of the uterus, where it begins to develop. An unfertilized egg will flow through the uterus and be excreted from the body.", "neg": "Many disorders of the reproductive system are not sexually transmitted infections. They are not caused by pathogens, so they dont spread from person to person. They develop for other reasons. The disorders are different between males and females. In both genders, the disorders could cause a little discomfort, or they could cause death. Most common disorders of the male reproductive system involve the testes. For example, injuries to the testes are very common. In teenagers, injuries to the testes most often occur while playing sports. An injury such as a strike or kick to the testes can be very painful. It may also cause bruising and swelling. Such injuries do not usually last very long. Another disorder of the testes is cancer. Cancer of the testes is most common in males aged 15 to 35. It occurs when cells in the testes grow out of control. The cells form a lump called a tumor. If found early, cancer of the testes usually can be easily cured with surgery. Disorders of the female reproductive system may affect the vagina, uterus, or ovaries. They may also affect the breasts. One of the most common disorders is vaginitis. This is redness and itching of the vagina. It may be due to irritation by soap or bubble bath. Another possible cause of vaginitis is a yeast infection. Yeast normally grow in the vagina. A yeast infection happens when the yeast multiply too fast and cause symptoms. A yeast infection can be treated with medication. Bubble baths may be fun, but for women and girls they can cause irritation to the vagina. A common disorder of the ovaries is an ovarian cyst. A cyst is a sac filled with fluid or other material. An ovarian cyst is usually harmless, but it may cause pain. Most cysts slowly disappear and do not need treatment. Very large or painful cysts can be removed with surgery. Many teen girls have painful menstrual periods. They typically have cramping in the lower abdomen. Generally, this is nothing to worry about. Taking a warm bath or using a heating pad often helps. Exercise can help as well. A pain reliever like ibuprofen may also work. If the pain is severe, a doctor can prescribe stronger medicine to relieve the pain. The most common type of cancer in females is breast cancer. The cancer causes the cells of the breast to grow out of control and form a tumor. Breast cancer is rare in teens. It becomes more common as women get older. If breast cancer is found early, it usually can be cured with surgery.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}269{"query": "Buoyancy is the ability of a fluid to exert an upward force on any object placed in the fluid. This upward force is called buoyant force. What explains buoyant force? Recall from the earlier lesson \"Pressure of Fluids\" that a fluid exerts pressure in all directions but the pressure is greater at greater depth. Therefore, the fluid below an object exerts greater force on the object than the fluid above the object. This is illustrated in Figure 15.12. Buoyant force explains why objects may float in water. No doubt youve noticed, however, that some objects do not float in water. If buoyant force applies to all objects in fluids, why do some objects sink instead of float? The answer has to do with their weight. Weight is a measure of the force of gravity pulling down on an object. Buoyant force pushes up on an object. Weight and buoyant force together determine whether an object sinks or floats. This is illustrated in Figure 15.13. If an objects weight is the same as the buoyant force acting on the object, then the object floats. This is the example on the left in Figure 15.13. If an objects weight is greater than the buoyant force acting on the object, then the object sinks. This is the example on the right in Figure 15.13. Because of buoyant force, objects seem lighter in water. You may have noticed this when you went swimming and could easily pick up a friend or sibling under the water. Some of the persons weight was countered by the buoyant force of the water. Density, or the amount of mass in a given volume, is also related to buoyancy. Thats because density affects weight. A given volume of a denser substance is heavier than the same volume of a less dense substance. For example, ice is less dense than liquid water. This explains why ice cubes float in a glass of water. This and other examples of density and buoyant force are illustrated in Figure 15.14 and in the video at this URL: MEDIA Click image to the left or use the URL below. URL: Did you ever notice that when you get into a bathtub of water the level of the water rises? More than 2200 years ago, a Greek mathematician named Archimedes noticed the same thing. He observed that both a body and the water in a tub cant occupy the same space at the same time. As a result, some of the water is displaced, or moved out of the way. How much water is displaced? Archimedes determined that the volume of displaced water equals the volume of the submerged object. So more water is displaced by a bigger body than a smaller one. What does displacement have to do with buoyant force? Everything! Archimedes discovered that the buoyant force acting on an object in a fluid equals the weight of the fluid displaced by the object. This is known as Archimedes law (or Archimedes Principle). Archimedes law explains why some objects float in fluids even though they are very heavy. Remember the oil tanker that opened this chapter? It is extremely heavy, yet it stays afloat. If a steel ball with the same weight as the ship were put into water, it would sink to the bottom (see Figure 15.15). Thats because the volume of water displaced by the steel ball weighs less than the ball. As a result, the buoyant force is not as great as the force of gravity acting on the ball. The design of the ships hull, on the other hand, causes it to displace much more water than the ball. In fact, the weight of the displaced water is greater than the weight of the ship, so the buoyant force is greater than the force of gravity acting on the ship. As a result, the ship floats. You can check your understanding of Archimedes law by doing the brainteaser at this URL: . For an entertaining video presentation of Archimedes law, go to this URL: [Link]", "pos": "Did you ever notice when you get into a bathtub of water that the level of the water rises? More than 2000 years ago, a Greek mathematician named Archimedes noticed the same thing. He observed that both a body and the water in a tub cant occupy the same space at the same time. As a result, some of the water is displaced, or moved out of the way. How much water is displaced? Archimedes determined that the volume of displaced water equals the volume of the submerged object. So more water is displaced by a bigger body than a smaller one. Q: If you jump into swimming pool, how much water does your body displace? A: The water displaced by your body is equal to your bodys volume. Depending on your size, this volume might be about 0.07 m3 . Objects such as ships may float in a fluid like water because of buoyant force. This is an upward force that a fluid exerts on any object that is placed in it. Archimedes discovered that the buoyant force acting on an object equals the weight of the fluid displaced by the object. This is known as Archimedes law (or Archimedes principle). Archimedes law explains why some objects float in fluids even though they are very heavy. It all depends on how much fluid they displace. The cruise ship pictured in the opening image is extremely heavy, yet it stays afloat. If a steel ball with the same weight as the ship were placed in water, it would sink to the bottom. This is modeled in the Figure 1.1. The reason the ball sinks is that its shape is very compact, so it displaces relatively little water. The volume of water displaced by the steel ball weighs less than the ball itself, so the buoyant force is not as great as the force of gravity pulling down on the ball. Thus, the ball sinks. Now look at the ships hull in the Figure 1.1. Its shape causes the ship to displace much more water than the ball. In fact, the weight of the displaced water is greater than the weight of the ship. As a result, the buoyant force is greater than the force of gravity acting on the ship, so the ship floats. Q: Why might you be more likely to float in water if you stretch out your body rather than curl up into a ball? A: You would displace more water by stretching out your body, so there would be more buoyant force acting on it. Therefore, you would be more likely to float in this position.", "neg": "Our planet was born some billions of years ago. Ever since this planet has developed, it has surprised us human beings. No matter how much we human beings have developed technologically, we cannot ever create this kind of natural planet. The human race can only discover some amazing facts about it. Let us find out what some of them are. On September 13, 1922 El Azizia, a place in Libya, recorded a temperature of 136 degrees Fahrenheit. This was the highest temperature ever measured on the planet Earth. The highest waterfall in the world is Angel Falls in Venezuela, which drops from an amazing height of 3,212 feet. The waterfall drops over the edge of Auyantepui in the Canaima National Park. The gravitational pull of the Earth can be escaped if someone moves at a speed of 6.95 miles per second. At such a speed, one could travel from New York to Philadelphia in just 20 seconds. If the entire water in the world's oceans evaporated, the salt we got from these oceans could cover the entire planet with a 500-foot deep layer of salt. The deepest lake on Earth is Lake Baikal in Russia. Lake Baikal is the largest freshwater lake in the world, containing about 20% of the world's unfrozen surface fresh water. The Andes in South America spreads over 4,525 miles. This is the longest mountain range in the world. Did you know that the biggest valley in the world is the Grand Valley in Mesa County, Colorado and Grand County, Utah? It is about 30 miles (48 km) long and 5 miles (8 km) wide, along the Colorado River. The amazing facts about the earth are too many to be told completely above.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}270{"query": "Australian Senator Nick Xenophon said, ''Tom Waterhouse has pushed the envelope to the extent that it has now got to the point that it's out of control and there needs to be a legislative response'' In May 2013, Waterhouse was directed by NSW Racing stewards to keep his bookmaking business clearly separate from the training business of his mother Gai Waterhouse, to avoid public perceptions of a conflict of interest.", "pos": "Tove Strand was formerly married to Rune Gerhardsen, a fellow Labour Party politician and son of former Prime Minister Einar Gerhardsen whom she met in university.", "neg": "Australia has promised to introduce the most comprehensive carbon trading program outside Europe in 2010. The government in Canberra plans to cut greenhouse gas emissions by at least five percent by 2020, but it could make bigger reductions if other countries agree to tougher targets. The Australian government warns that without tough environmental measures the country could lose key industries and jobs. Climate Change Minister Penny Wong says the economy is under threat and decisive action is needed. Central to the government's climate change plan is a carbon emissions trading program that will be introduced within two years. It would involve one thousand of the nation's biggest companies and would cover about three-quarters of Australia's greenhouse gas emissions. Many scientists believe that greenhouse gases, such as carbon dioxide and methane, contribute to global warming. Many of them are released by burning fuels such as coal and oil. Companies will be required to buy permits for each ton of carbon they emit, although big polluting exporters will receive up to 90 percent of their carbon licenses free. Many business leaders want the government to delay the plan because of the current global financial crisis, which is slowing the Australian economy. Peter Anderson from the Australian Chamber of Commerce and Industry says it is irresponsible to bring in a carbon trading plan now. Environmentalists, on the other hand, say Prime Minister Kevin Rudd has not properly addressed the threat of climate change. Activists had sought a minimum emissions cut of 25 percent. Instead, the Rudd government aims to cuts carbon emissions by at least five percent of 2000 levels by 2020. That amount could rise to 15 percent, if future global agreements set such a target. Ray Nias of the environmental group WWF says Australia will pay the price for low targets. \"This is a deeply, deeply disappointing target,\" Nias said. \"It commits Australia to long-term climate change. It will make Australia's ability to negotiate global agreements very, very difficult. It is much lower than even we had imagined.\" Australia has one of the highest per-person greenhouse emissions rates in the world because of its reliance on coal for electricity. _", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}271{"query": "A 45-year-old man developed chorea, behavioural changes, moderate amyotrophy and polyneuropathy. Hypertrophic cardiomyopathy and increased serum lactate dehydrogenase and creatine kinase (CK) were found. Acanthocytes were not detected. The absence of XK protein and faintly expressed Kell antigens on erythrocytes were found. Genetic test revealed a R133X mutation of the XK gene, confirming the McLeod syndrome. After 7 years he suddenly developed delirium followed by severe hypoglycaemia, hyperthermia, rhabdomyolysis, hepatic and renal failure. Malignant arrhythmia caused death.", "pos": "We report a novel mutation in the XK gene (XK) in a Japanese patient with McLeod syndrome. A 50-year-old man showed progressive muscular atrophy, choreic movement, elevated level of serum creatinine kinase, and acanthocytosis. The expression level of all the Kell antigens in erythrocyte was decreased and molecular analysis revealed a single-base (T) deletion at the nucleotide position 1095 in XK. This deletion caused a frameshift in translation, leading to a premature stop codon at the amino acid position 408. We conclude this single-base deletion causes defective Kx protein, which is responsible for the McLeod phenotype in this patient.", "neg": "The authors reported a 73-year-old alcoholic man with previously-unrecognized situs inversus totalis suffering from left upper quadrant pain. Acute myocardial infarction was diagnosed and coronary angioplasty was performed immediately. However, the massive bleeding from the previously-unfound hepatomas caused hypovolemic shock and fatal outcome. Situs inversus totalis is a rare congenital anomaly with a complete mirror image of the thoracic and abdominal organs. Although being considered a benign entity, it would disturb diagnosis-making of the visceral diseases owing to the altered anatomy. To our knowledge, the coexistence of the coronary artery disease and ruptured hepatomas in situs inversus totalis, as in our patient, is never described. Recognition of any situs anomalies in time is the key to avoid misdiagnosis, inappropriate managements, and unwanted consequences.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}272{"query": "Between 1911 and 1912, over 1,000 Somalis from Mogadishu, the then capital of Italian Somaliland, served as combat units along with Eritrean and Italian soldiers in the Italo-Turkish War. Most of the troops stationed never returned home until they were transferred back to Italian Somaliland in preparation for the invasion of Ethiopia in 1935. The first disembarkation of Italian troops occurred on October 10. The Italian contingent of 20,000 troops was deemed sufficient to accomplish the conquest at the time. Tobruk, Derna and Khoms were easily conquered, but the same was not true for Benghazi. The first true setback for the Italian troops happened on October 23, when poor placement of the troops near Tripoli led them to be almost completely encircled by more mobile Arab cavalry, backed by some Turkish regular units. The attack was portrayed as a simple revolt by the Italian press, but it nearly annihilated much of the small Italian expeditionary corps. The corps was consequently enlarged to 100,000 men who had to face 20,000 Arabs and 8,000 Turks. The war turned into one of position. Even some of the earliest examples of utilisation in modern warfare of armoured cars and air power by the Italian forces had little effect on the initial outcome. However, the war was notable for the first military use of heavier-than-air craft. Capitano Carlo Piazza flew the first military reconnaissance flight on 23 October 1911. A week later, Sottotenente Giulio Gavotti dropped four grenades on Taguira and Ain Zara in history's first aerial bombing.", "pos": "The army defending Constantinople was relatively small, totaling about 7,000 men, 2,000 of whom were foreigners. At the onset of the siege, probably fewer than 50,000 people were living within the walls, including the refugees from the surrounding area.:32 Turkish commander Dorgano, who was in Constantinople in the pay of the Emperor, was also guarding one of the quarters of the city on the seaward side with the Turks in his pay. These Turks kept loyal to the Emperor and perished in the ensuing battle. The defending army's Genoese corps were well trained and equipped, while the rest of the army consisted of small numbers of well-trained soldiers, armed civilians, sailors and volunteer forces from foreign communities, and finally monks. The garrison used a few small-calibre artillery pieces, which nonetheless proved ineffective. The rest of the city repaired walls, stood guard on observation posts, collected and distributed food provisions, and collected gold and silver objects from churches to melt down into coins to pay the foreign soldiers. The Ottomans had a much larger force. Recent studies and Ottoman archival data state that there were about 50,000-80,000 Ottoman soldiers including between 5,000 and 10,000 Janissaries, *70 cannons:139-140 an elite infantry corps, and thousands of Christian troops, notably 1,500 Serbian cavalry that the Serbian lord ura Brankovic was forced to supply as part of his obligation to the Ottoman sultanjust a few months before, he had supplied the money for the reconstruction of the walls of Constantinople. Contemporaneous Western witnesses of the siege, who tend to exaggerate the military power of the Sultan, provide disparate and higher numbers ranging from 160,000 to 200,000 and to 300,000.", "neg": "In May 1918, a conservative-monarchist Senate was formed by J. K. Paasikivi, and the Senate asked the German troops to remain in Finland. 3 March 1918 Treaty of Brest-Litovsk and 7 March German-Finnish agreements bound White Finland to the German Empire's sphere of influence. General Mannerheim resigned his post on 25 May after disagreements with the Senate about German hegemony over Finland, and about his planned attack on Petrograd to repulse the Bolsheviks and capture Russian Karelia. The Germans opposed these plans due to their peace treaties with Lenin. The Civil War weakened the Finnish Parliament; it became a Rump Parliament that included only three socialist representatives. On 9 October 1918, under pressure from Germany, the Senate and Parliament elected a German prince, Friedrich Karl, the brother-in-law of German Emperor William II, to become the King of Finland. The German leadership was able to utilise the breakdown of Russia for the geopolitical benefit of the German Empire in Fennoscandia also. The Civil War and the aftermath diminished independence of Finland, compared to the status it had held at the turn of the year 1917-1918. The economic condition of Finland deteriorated drastically from 1918; recovery to pre-conflict levels was achieved only in 1925. The most acute crisis was in food supply, already deficient in 1917, though large-scale starvation had been avoided that year. The Civil War caused marked starvation in southern Finland. Late in 1918, Finnish politician Rudolf Holsti appealed for relief to Herbert Hoover, the American chairman of the Committee for Relief in Belgium. Hoover arranged for the delivery of food shipments and persuaded the Allies to relax their blockade of the Baltic Sea, which had obstructed food supplies to Finland, and to allow food into the country.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}273{"query": "Something that is elastic can return to its original shape after being stretched or compressed. This property is called elasticity. As you stretch or compress an elastic material, it resists the change in shape. It exerts a counter force in the opposite direction. This force is called elastic force. Elastic force causes the material to spring back to its original shape as soon as the stretching or compressing force is released. You can watch a demonstration of elastic force at this URL: (3:57). MEDIA Click image to the left or use the URL below. URL: Elastic force can be very useful. You probably use it yourself every day. A few common uses of elastic force are pictured in Figure 13.25. Did you ever use a resistance band like the one in the figure? When you pull on the band, it stretches but doesnt break. The resistance you feel when you pull on it is elastic force. The resistance of the band to stretching is what gives your muscles a workout. After you stop pulling on the band, it returns to its original shape, ready for the next workout. Springs like the ones in Figure 13.26 also have elastic force when they are stretched or compressed. And like stretchy materials, they return to their original shape when the stretching or compressing force is released. Because of these properties, springs are used in scales to measure weight. They also cushion the ride in a car and provide springy support beneath a mattress. Can you think of other uses of springs?", "pos": "Force is defined as a push or a pull acting on an object. Examples of forces include friction and gravity. Both are covered in detail later in this chapter. Another example of force is applied force. It occurs when a person or thing applies force to an object, like the girl pushing the swing in Figure 13.1. The force of the push causes the swing to move. Force is a vector because it has both size and direction. For example, the girl in Figure 13.1 is pushing the swing away from herself. Thats the direction of the force. She can give the swing a strong push or a weak push. Thats the size, or strength, of the force. Like other vectors, forces can be represented with arrows. Figure 13.2 shows some examples. The length of each arrow represents the strength of the force, and the way the arrow points represents the direction of the force. How could you use an arrow to represent the girls push on the swing in Figure 13.1? The SI unit of force is the newton (N). One newton is the amount of force that causes a mass of 1 kilogram to accelerate at 1 m/s2 . Thus, the newton can also be expressed as kgm/s2 . The newton was named for the scientist Sir Isaac Newton, who is famous for his law of gravity. Youll learn more about Sir Isaac Newton later in the chapter. More than one force may act on an object at the same time. In fact, just about all objects on Earth have at least two forces acting on them at all times. One force is gravity, which pulls objects down toward the center of Earth. The other force is an upward force that may be provided by the ground or other surface. Consider the example in Figure 13.3. A book is resting on a table. Gravity pulls the book downward with a force of 20 newtons. At the same time, the table pushes the book upward with a force of 20 newtons. The combined forces acting on the book or any other object are called the net force. This is the overall force acting on an object that takes into account all of the individual forces acting on the object. You can learn more about the concept of net force at this URL: . When two forces act on an object in opposite directions, like the book on the table, the net force is equal to the difference between the two forces. In other words, one force is subtracted from the other to calculate the net force. If the opposing forces are equal in strength, the net force is zero. Thats what happens with the book on the table. The upward force minus the downward force equals zero (20 N up - 20 N down = 0 N). Because the forces on the book are balanced, the book remains on the table and doesnt move. In addition to these downward and upward forces, which generally cancel each other out, forces may push or pull an object in other directions. Look at the dogs playing tug-of-war in Figure 13.4. One dog is pulling on the rope with a force of 10 newtons to the left. The other dog is pulling on the rope with a force of 12 newtons to the right. These opposing forces are not equal in strength, so they are unbalanced. When opposing forces are unbalanced, the net force is greater than zero. The net force on the rope is 2 newtons to the right, so the rope will move to the right. Two forces may act on an object in the same direction. You can see an example of this in Figure 13.5. After the man on the left lifts up the couch, he will push the couch to the right with a force of 25 newtons. At the same time, the man to the right is pulling the couch to the right with a force of 20 newtons. When two forces act in the same direction, the net force is equal to the sum of the forces. This always results in a stronger force than either of the individual forces", "neg": "An electromagnetic wave is a wave that consists of vibrating electric and magnetic fields. A familiar example will help you understand the fields that make up an electromagnetic wave. Think about a common bar magnet. It exerts magnetic force in an area surrounding it, called the magnetic field. You can see the magnetic field of a bar magnet in Figure 21.1. Because of this force field, a magnet can exert force on objects without touching them. They just have to be in its magnetic field. An electric field is similar to a magnetic field (see Figure 21.1). An electric field is an area of electrical force surrounding a charged particle. Like a magnetic field, an electric field can exert force on objects over a distance without actually touching them. An electromagnetic wave begins when an electrically charged particle vibrates. This is illustrated in Figure 21.2. When a charged particle vibrates, it causes the electric field surrounding it to vibrate as well. A vibrating electric field, in turn, creates a vibrating magnetic field (you can learn how this happens in the chapter \"Electromagnetism\"). The two types of vibrating fields combine to create an electromagnetic wave. You can see an animation of an electromagnetic wave at this URL: (1:31). MEDIA Click image to the left or use the URL below. URL: As you can see in Figure 21.2, the electric and magnetic fields that make up an electromagnetic wave occur are at right angles to each other. Both fields are also at right angles to the direction that the wave travels. Therefore, an electromagnetic wave is a transverse wave. Unlike a mechanical transverse wave, which requires a medium, an electromagnetic transverse wave can travel through space without a medium. Waves traveling through a medium lose some energy to the medium. However, when an electromagnetic wave travels through space, no energy is lost, so the wave doesnt get weaker as it travels. However, the energy is \"diluted\" as it spreads out over an ever-larger area as it travels away from the source. This is similar to the way a sound wave spreads out and becomes less intense farther from the sound source. Electromagnetic waves can travel through matter as well as across space. When they strike matter, they interact with it in the same ways that mechanical waves interact with matter. They may reflect (bounce back), refract (bend when traveling through different materials), or diffract (bend around objects). They may also be converted to other forms of energy. Microwaves are a familiar example. They are a type of electromagnetic wave that you can read about later on in this chapter, in the lesson \"The Electromagnetic Spectrum.\" When microwaves strike food in a microwave oven, they are converted to thermal energy, which heats the food. Electromagnetic radiation behaves like waves of energy most of the time, but sometimes it behaves like particles. As evidence accumulated for this dual nature of electromagnetic radiation, the famous physicist Albert Einstein developed a new theory about electromagnetic radiation, called the wave-particle theory. This theory explains how electromagnetic radiation can behave as both a wave and a particle. In brief, when an electron returns to a lower energy level, it is thought to give off a tiny \"packet\" of energy called a photon (see Figure 21.3). The amount of energy in a photon may vary. It depends on the frequency of electromagnetic radiation. The higher the frequency is, the more energy a photon has. The most important source of electromagnetic radiation on Earth is the sun. Electromagnetic waves travel from the sun to Earth across space and provide virtually all the energy that supports life on our planet. Many other sources of electromagnetic waves that people use depend on technology. Radio waves, microwaves, and X rays are examples. We use these electromagnetic waves for communications, cooking, medicine, and many other purposes. Youll learn about all these types of electromagnetic waves in this chapters lesson on \"The Electromagnetic Spectrum.\"", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}274{"query": "Set in the Australian outback in the 1880s, the movie follows the series of events following the horrific rape and murder of the Hopkins family, allegedly committed by the infamous Burns brothers gang.The film opens in a brothel during a violent gunfight between the police and Charlie Burns' (Guy Pearce) gang, which ends with the deaths of all of the gang members except for Charlie and his younger brother Mikey. Captain Stanley (Ray Winstone) proposes to Charlie: he and Mikey can go free of the crimes they have committed if Charlie kills his older brother, Arthur (Danny Huston). Arthur is a mercurial psychopath who has become something of a legend and is so vicious that the Aboriginal tribes refer to him as \"The Dog Man\" and both the police and the Aboriginals refuse to go near his camp. Captain Stanley muses that perhaps the bounty hunters will kill Arthur in time and then states his intention to civilize the harsh Australian wilderness by bringing Arthur to justice and using Mikey as leverage. Charlie has nine days to find and kill Arthur, or else Mikey will be hanged from the gallows on Christmas Day.We discover why Captain Stanley is intent on taming Australia: he has been forced to move there with his delicate wife, Martha Stanley (Emily Watson), and apparently wants to make it an appropriate place for them to live. The Stanleys were also friends of the Hopkins family, leading Martha to have nightmares about her dead friends and the unborn child one of them is revealed to have carried. Word spreads of Stanley's deal with Charlie, primarily from Stanley's corrupt subordinate, Sergeant Lawrence (Robert Morgan), causing disgust among the townspeople.Shortly thereafter, Eden Fletcher (David Wenham), for whom Captain Stanley works, orders that Mikey be given one hundred lashes as punishment for the rape and murder of the Hopkins family. Stanley is aghast at this, not only because he believes that Mikey is innocent and the flogging will surely kill him, but because it would also break his deal with Charlie and thus put him and his wife in grave danger. Stanley sends Sergeant Lawrence away with tracker Jacko (David Gulpillil) and other men to \"investigate\" the reported slaying of Dan O'Riley by a group of Aborigines. Captain Stanley attempts to defend Mikey by gunpoint from the bloodthirsty townspeople, but is overruled once Martha arrives, insisting on revenge for her dead friends. Mikey is then brutally flogged, and horrifically wounded. The formerly excited townspeople slowly become disgusted and Martha faints at the ghastly display. After 40 lashes, Mikey has collapsed and the whip is soaked with blood. Captain Stanley grabs the whip and throws it at Fletcher, staining his face and suit with blood, who in turn fires Stanley.Meanwhile, Charlie rides a great distance in search of Arthur, drinking and apparently reflecting on what he will do. Along the way, he encounters an inebriated old man named Jellon Lamb (John Hurt). In the course of conversation, Charlie realizes that Lamb is a bounty hunter in pursuit of the Burns brothers and knocks him out. Later on, after sleeping on a rock bed, Charlie awakes and, before he can gather what's going on, is speared in the chest by a group of Aboriginal men standing over him. Seconds later a gunshot is heard and the head of the man who threw the spear explodes. Charlie then passes out.Charlie wakes up in the camp of his brother Arthur, which is located in caves among desolate mountains. Arthur's gang consists of Samuel Stoat (Tom Budge), who shot the Aboriginal man who had speared Charlie; a woman named Queenie (Leah Purcell) who tends to Charlie's wound; and a muscular Aboriginal man called Two-Bob (Tom E. Lewis). As he recovers from his wounds, Charlie has several opportunities to kill his brother, but does not. Not too far away from Arthur's camp, Sergeant Lawrence and his men have found and butchered a group of Aborigines. Arthur and Two-Bob find Lawrence's group while they sleep, ostensibly to get a horse for Charlie, and proceed to kill Jacko and Sergeant Lawrence. Before Arthur stomps Lawrence", "pos": "Claude Rains and James Stewart in Mr. Smith Goes to Washington Play media Trailer James Stewart and Jean Arthur in a taxicab The governor of an unnamed western state, Hubert \"Happy\" Hopper (Guy Kibbee), has to pick a replacement for recently deceased U.S. Senator Sam Foley. His corrupt political boss, Jim Taylor (Edward Arnold), pressures Hopper to choose his handpicked stooge, while popular committees want a reformer, Henry Hill. The governor's children want him to select Jefferson Smith (James Stewart), the head of the Boy Rangers. Unable to make up his mind between Taylor's stooge and the reformer, Hopper decides to flip a coin. When it lands on edge and next to a newspaper story on one of Smith's accomplishments he chooses Smith, calculating that his wholesome image will please the people while his naivete will make him easy to manipulate. Junior Senator Smith is taken under the wing of the publicly esteemed, but secretly crooked, Senator Joseph Paine (Claude Rains), who was Smith's late father's friend. Smith develops an immediate attraction to the senator's daughter, Susan (Astrid Allwyn). At Senator Paine's home, Smith has a conversation with Susan, fidgeting and bumbling, entranced by the young socialite. Smith's naive and honest nature allows the unforgiving Washington press to take advantage of him, quickly tarnishing Smith's reputation with ridiculous front page pictures and headlines branding him a bumpkin. To keep Smith busy, Paine suggests he propose a bill. With the help of his secretary, Clarissa Saunders (Jean Arthur), who was the aide to Smith's predecessor and had been around Washington and politics for years, Smith comes up with a bill to authorize a federal government loan to buy some land in his home state for a national boys' camp, to be paid back by youngsters across America. Donations pour in immediately. However, the proposed campsite is already part of a dam-building graft scheme included in an appropriations bill framed by the Taylor political machine and supported by Senator Paine. Unwilling to crucify the worshipful Smith so that their graft plan will go through, Paine tells Taylor he wants out, but Taylor reminds him that Paine is in power primarily through Taylor's influence. Through Paine, the machine in his state accuses Smith of trying to profit from his bill by producing fraudulent evidence that Smith already owns the land in question. Smith is too shocked by Paine's betrayal to defend himself, and runs away. Saunders, who looked down on Smith at first, but has come to believe in him, talks him into launching a filibuster to postpone the appropriations bill and prove his innocence on the Senate floor just before the vote to expel him. In his last chance to prove his innocence, he talks non-stop for about 24 hours, reaffirming the American ideals of freedom and disclosing the true motives of the dam scheme. Yet none of the Senators are convinced. The constituents try to rally around him, but the entrenched opposition is too powerful, and all attempts are crushed. Owing to the influence of Taylor's machine, newspapers and radio stations in Smith's home state, on Taylor's orders, refuse to report what Smith has to say and even distort the facts against the senator. An effort by the Boy Rangers to spread the news in support of Smith results in vicious attacks on the children by Taylor's minions. Although all hope seems lost, the senators begin to pay attention as Smith approaches utter exhaustion. Paine has one last card up his sleeve: he brings in bins of letters and telegrams from Smith's home state, purportedly from average people demanding his expulsion. Nearly broken by the news, Smith finds a small ray of hope in a friendly smile from the President of the Senate (Harry Carey). Smith vows to press on until people believe him, but immediately collapses in a faint. Overcome with guilt, Paine leaves the Senate chamber and attempts to commit suicide, but is stopped by other senators. When he is stopped, he bursts back into the Senate chamber, loudly confessing to the whole scheme;", "neg": "Upon receiving a divorce in Reno, Helen Trent (Claire Trevor) plans to return to San Francisco and goes back to the boarding house where she is renting a room from Mrs. Kraft (Esther Howard) but discovers two dead bodies in the kitchen. Sam Wild (Lawrence Tierney) is the murderer and has committed the crime out of a jealous drive - one of the bodies was his girl friend Laury Palmer (Isabel Jewell) and the other a new man she was dating. Helen grabs her bags and heads for the train and coincidentally Sam does too pushed by his close friend Marty Waterman (Elisha Cook, Jr.) who stays in Reno to get details on the murder and agrees to meet Sam later. Coincidentally Sam and Helen meet on the train and are attracted to each other in part because in a casino earlier they had flirted across the Craps table. In San Francisco Helen parts with Sam but he crashes in on her and her fiancee Fred Grover (Phillip Terry) and her half-sister Georgia Staples (Audrey Long) who has inherited a large newspaper company. Sam sees a good thing in Grace and successfully seduces her into marrying him partly for the power her money can bring him but also to sustain the attraction he has for Helen. Mrs. Kraft hires seedy private detective Matthew Arnett (Walter Slezak) to find out who killed her good friend Laury and the shamus arrives on the wedding day of Sam and Georgia. Helen manages to leak some information to Arnett but Sam discovers this as well and gets his buddy Marty to track down Mrs. Kraft to put an end to things. But this plan goes awry when Marty stops to try to get more information from Helen and Sam perceives it as a play for the woman. Sam reacts in a jealous pique and Helen realizes that he must be stopped and calls Arnett to bring the police with the information he has gathered from his investigation. Sam discovers Helen's communication with Arnett and pulls his gun just as the police arrive resulting in a climactic shootout.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}275{"query": "Here are some books published this year. The following introductions of these books may help you choose a book to your own taste. Life Simplified If you are looking for a book that will transform your life for good, Life Simplified is that book. If you are looking for a guide to inspire and lead you back to your inherent self, Life simplified will act as your compass. Life Simplified provides readers with a carefully mapped approach to create life changes. The reader will develop a sense of personal pride in their progress as each chapter is completed, motivating them further. The book is an absolute must read if you would like an uncomplicated method in positively improving your life. Building the Best You How can you become the person you've always dreamed of being? Personal transformation begins when you take stock of where you are and what you are doing right now...and work to change it. All you have to do is to answer some basic questions and take five minutes of \"focus time\" daily to get there. You are responding to questions like \"What am I grateful for today?\", \"What challenged me?\" and \"How can I overcome that challenge?\" The Gifts of Imperfection In this latest book, the writer Brown emphasizes that above all other ingredients of living an emotionally healthy life is the importance of loving ourselves. The point is to embrace life and oneself with all the imperfections, releasing the stress of overdoing and overworking. Brown offers exercises for readers to understand their own emotions and begin to develop the kind of resilience needed to refuse unrealistic expectations of others and ourselves. The Strengths Book You are remarkable. But do you always realize it? Realize your strengths and you will be realizing the best of you. Do you want to be confident, successful, and sustainably happy? Do you want to achieve your goals and enjoy better relationships? The Strengths Book reveals the sixty strengths that make us who we are. If you are a manager, a parent, a career changer, or even just you, remarkable as you are, The Strengths Book is for you. Discover your strengths--what you do best and love to do--and transform your life by realizing the best of you.", "pos": "The Most Scenic Drives in America Price: $25.00 Description: This book includes 120 easytofollow maps, 400 breathtaking photos, fascinating facts, tips, suggested side trips and much more. What Works What Doesn't: The Bottom Line on Everything Health Price:$31.96 Description: Now, with What Works What Doesn't, you can stop wasting time and money on products, treatments and approaches that don't work, and start getting real results from strategies that do. Strange Stories, Amazing Facts of America's Past Price: $34.96 Description: If you ever thought history was dull and our forefathers stodgy, here is a book to change your mind.This is America at its most fascinating--more than 600 true stories as gripping as a whodunit, as fast paced as a spy chase, as atmospheric as a historical novel--guaranteed to give many hours of reading pleasure. How To Write Your Life Story Price: $26.95 Description: Discover how easy it is to write your own life story! This fascinating and practical guide leads you through the process of creating your own personal memoir. Plus, find out how to use photos and other mementos to add even more meaning to your story. Disease Free Price: $31.96 Description:Stop Disease Before it Starts. Doctors estimate that at least 60% of chronic disease cases could be avoided entirely, and Disease Free shows you how. Detailed prevention plans for more than 90 conditions help you sidestep everything from heartburn to high blood pressure, colds to cancer. Complete Guitar Course Price:$30.00 Description: Learn to play in 20 easytofollow lessons! This deluxe handbook is packed with everything you need to learn from choosing the right guitar for you, to basic fingering, chords, and techniques. Handsomely designed in full color1 and jammed with practical tips, this comprehensive course will have you making beautiful music in no time at all! Care Free Plants Price:$34.96 Description: This book reveals the secret to great gardening: working smarter, not harder. Discover how you can spend less effort, save money, and still end up with more time to enjoy your beautiful garden. With this book in hand, the dream is within easy reach.", "neg": "With the new school year quickly coming near (or perhaps, for your early-starters, already under way), it's time to get ready for a successful term . And while you may be cleaning your wardrobe , it's equally important to freshen up your study skills, too. Have you ever noticed that your study habits are different from those of your friends? Or how you seem to learn faster in certain classes? Some people are quick to blame the teacher or subject for their difficulties, but that isn't always the cause . One thing that many people seem to ignore is their learning type. Now, you may be wondering what a learning type is and how to find yours. There are three different learning types: Visual, Auditory, and Kinesthetic. You can be a _ of learning types, but most people have one main type. 1. Visual learners learn best by seeing. If you seem to easily get information from pictures, graphs, and videos, you are likely a visual learner. 2. Auditory learners learn best by hearing. If you seem to remember things by hearing them, whether listening to a lecture or repeating information out loud, then you are likely an auditory learner. 3. Kinesthetic learners learn best by doing. If you seem to learn best by working with your hands or testing out what you are shown, you are likely a kinesthetic learner. So now that you know your personal learning style, the trick is to find out how to use your new-found knowledge to help you in your classes.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}276{"query": "Daniel Hillard is a freelance voice actor living in San Francisco, California. Though a devoted and loving father to his three children Lydia, Chris, and Natalie, Daniel is an unreliable husband. One day, he quits his job due to a disagreement over a questionable script, then throws a wild birthday party for Chris with a petting zoo against his wife Miranda's objections. Returning home from work due to a neighbor's complaint, Miranda is angry at Daniel for planning the party behind her back and, after an argument, files for divorce. At their first custody hearing, the judge initially grants Miranda sole custody of the children since Daniel has neither a residence nor a steady job, but rules that if Daniel gets a steady job and a residence suitable for children within three months, he will allow Daniel and Miranda to share joint custody. As Daniel attempts to rebuild his life, he learns that Miranda intends to hire a housekeeper and secretly alters her classifieds form when she declines his offer to take care of the children. He then calls Miranda several times, using his voice acting skills as several bad job applicants. Finally, he calls as a Scottish-accented[4] nanny, whom he calls Mrs. Euphegenia Doubtfire, taking the last name from a newspaper headline. Impressed with her alleged qualifications, Miranda invites \"Mrs. Doubtfire\" for an interview. Daniel enlists his older brother Frank, a makeup artist, and his partner Jack to transform him into the character. After being further impressed by the interview, Miranda hires Mrs. Doubtfire. The children initially struggle to adjust to Mrs. Doubtfire's methods, but they soon begin to thrive, becoming happier and doing better in school. At the same time, Miranda is able to heal her strained relationship with the children as she and Mrs. Doubtfire become good friends. Daniel has to learn several skills to play his role, such as cooking and cleaning, and also improves himself. However, despite impressing Miranda greatly with his newfound maturity, Daniel realizes that he has indirectly created another barrier, as when he asks to look after the children again one night, Miranda insists she could never dismiss Mrs. Doubtfire as the family's lives have been made so much better by \"her.\" One night, Lydia and Chris accidentally discover that Mrs. Doubtfire is actually Daniel in disguise and though initially shocked by the revelation, they are overjoyed that their father is back in their lives and agree to keep his disguise a secret. Daniel also takes a menial job at a television station. One day, CEO Jonathan Lundy sees Daniel playing around with toy dinosaurs on the set of an unsuccessful children's program and, impressed with Daniel's creativity, invites him to dinner at Bridge's Restaurant on the coming Friday night for Daniel to pitch ideas as a possible new host. Meanwhile, Miranda expects Mrs. Doubtfire to attend a birthday dinner arranged by her new love interest, Stu Dunmire, at the same time and place. Unable to postpone his dinner with Lundy and not wanting to disappoint his family, Daniel goes to the restaurant and tries to rotate between both dinners, changing in and out of the Mrs. Doubtfire costume in the restroom; however, he becomes drunk as both tables provide him with numerous alcoholic beverages. After seasoning Stu's food with cayenne pepper, which Stu is allergic to, Daniel forgets to change out of the Mrs. Doubtfire costume before returning to Mr. Lundy's table. When Lundy questions the costume, Daniel quickly covers for his mistake by explaining that his alter-ego is his idea for a television persona, impressing Lundy. At Miranda's table, Stu starts choking. Regretful, Daniel administers the Heimlich maneuver, partially ripping off his mask in the process and revealing his identity, to Miranda's horror. At their next custody hearing, Daniel shows that he has a job and a suitable home, then explains his actions. The judge, however, is disturbed by Daniel's actions, and grants Miranda full custody, with Daniel limited to supervised visitation once a week, leaving Daniel heartbroken. Without Mrs. Doubtfire, the children again become miserable and even Miranda admits their lives were so much better with \"her", "pos": "Anna Foster (Mandy Moore) is the daughter of the President of the United States, James (Mark Harmon) and First Lady Michelle Foster (Caroline Goodall).When a hassle of Secret Service agents ruins a first date, Anna demands some freedom. Her dad agrees to send only two agents with Anna and Gabrielle La Clare (Beatrice Rosen) to a concert when Anna goes to Prague with her parents. A sexy new look for Anna causes her father to renege. When Anna discovers the concert is filled with agents and that her father has broken his promise, Gabrielle helps Anna elude her protectors. Outside the concert, Anna meets Ben Calder (Matthew Goode), and asks him to drive her to escape the agents. Anna goes to a bar with Ben and proceeds to get drunk. Unbeknownst to Anna, Ben is with the Secret Service, and tells agents Alan Weiss (Jeremy Piven) and Cynthia Morales (Annabella Sciorra) where Anna is. The President orders the three agents to have Ben guard Anna without telling her who he really is, to give her an illusion of freedom with a guarantee of safety. Believing herself free of her guards for the first time in years, Anna jumps into the Vltava River naked, mistaking it for the Danube, and Ben has to fish her out (he stays clothed). Weiss and Morales buy the camera from someone taking pictures of the skinny-dipping Anna. Anna and Ben climb a rooftop to watch an opera being shown in a plaza, where Anna eventually falls asleep with Ben guarding her, and Weiss and Morales watching from another roof.The next morning, Anna calls her parents to avoid getting into further trouble with them. Knowing she is safe, her father is initially indulgent, and Anna is about to return, but his tone changes when he is shown the photos of her nude in the river. The First Lady, however, asks, \"What happened to 'let freedom ring?'\" (That had been his earlier line when he had decided to let her stay out with Ben.) Anna is outraged at both her dad's sudden imperious tone and finding out that he traced her call. She decides to meet Gabrielle at the Love Parade in Berlin and return to her parents right before the plane trip home. Ben goes with her on the train, where they meet Scotty McGruff (Martin Hancock), a flighty romantic obsessed with Six Million Dollar Man stickers and the interconnectivity of the world, he gives them a stack of stickers and tells them to stick them up in random places, then one day when they are unhappy, they will see one and it will make them smile. Through him, the two learn that they have boarded a Venice-bound train. When they arrive in Venice, Ben calls the other agents to tell them where they are but has to leave the phone dangling when he realizes he can no longer see Anna. He finds her and McGruff getting new clothes, and the three explore Venice - until McGruff steals their wallets. Ben is about to tell the cafe they cannot pay when Anna is recognized and races off to avoid being identified as the First Daughter. Ben follows, and they tell a story of marrying, against the wishes of Anna's parents, to get a gondola ride from a kind-hearted gondolier, Eugenio (Joseph Long). Ben kisses Anna during the ride to hide her from the cafe staff's sight. Since they have no place to stay, Eugenio invites them to his and his mother Maria's (Miriam Margolyes) house. That night, thinking the kiss meant that Ben cares for her, Anna offers herself to him. To dissuade her, Ben is disingenuous and harsh. Anna finally gets in the bed alone, while Ben lies on the floor.The next day, Eugenio drives them to the Austrian border, as Weiss and Morales show up at Maria's looking for the gondolier with whom Anna and Ben were last seen. Maria tells them that Anna and Ben are married, which is reported to Anna's parents. Upset that Ben rejected her, Anna gets a ride on a truck, leaving Ben to", "neg": "Jonathan Shale (Berenger) is a mercenary and a Vietnam veteran who returns home to Miami after a botched covert operation in Cuba in which three men from his platoon were killed. He surprises his girlfriend, Jane Hetzko (Diane Venora) at her apartment and is warmly welcomed. On the outside, Jane is a schoolteacher at inner-city Columbus High School, an institution with a considerable gang problem. She is particularly disliked by Juan Lacas (Anthony), leader of the KOD (\"Kings of Destruction\") gang. While jogging one morning, Jane is attacked and has her leg broken. Jane and Shale believe this to be related to the KOD, which prompts the latter to go undercover as an Ivy League-educated, government-affiliated substitute teacher for his girlfriend's class. Shale arrives at Columbus High School and is, at first, taken back by the lowly conditions. He is unable to control his class of poorly-educated students on the first day, but decides to use his street-smarts and military tactics to gain the upper hand. Soon enough, he is able to take command of the students by displaying his combat self-defence techniques when students attack him. He is warned not to use such methods by Principal Claude Rolle (Hudson), but gains the respect of his students when he bonds with them over the similarities between his early gang and Vietnam War experiences and their involvement in petty crime and street gangs. During this time, he befriends fellow schoolteacher Darrell Sherman (Plummer) and also crosses paths with Lacas, one of his students. Suspicious of odd conditions within the high school, Shale sets up surveillance cameras throughout the building. He discovers that Lacas orchestrated the attack on Jane. He also discovers that Lacas is secretly working with Rolle to distribute cocaine around Miami for a major narcotics ring. Shale and his team raid a drug deal, using the stolen money to buy music and sports equipment in the form of a \"school donation.\" While Sherman initially denies Shale's discovery, Sherman and a female student inadvertently witness the drugs being loaded into one of the school buses later that day. Sherman tells the student to warn Shale and Hetzko, and sacrifices himself by creating a distraction. Rolle, who at this point is aware of Shale's interference orders a \"car accident\" for Shale, and sends Lacas after Hetzko. With the help of another student, Lacas is killed and Shale saves Hetzko, learning the full story from the female witness. Shale and his team garrison the school grounds to enter combat against the remaining K.O.D. members, a rival mercenary company led by Janus, and Rolle himself. Ultimately, Shale and Joey Six end up as the sole survivors of the battle, walking away from the school grounds discussing future operations as substitute teachers.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}277{"query": "Rosemary's Billygoat is an American heavy metal/hard rock band formed in Los Angeles ' South Bay in 1991, consisting of singer Mike Odd, guitarist Neal Gargantua, bassist Pat Trick and drummer Paul Bearer.", "pos": "Street Dogs are an American punk rock band from Boston, MA, formed in 2002 by former Dropkick Murphys singer Mike McColgan.", "neg": "Restless in the Tides is the first full-length album by heavy metal music group Forever in Terror.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}278{"query": "On a brief trip back to London, earnest, bookish bacteriologist Walter Fane (Edward Norton) is dazzled by Kitty Garstin (Naomi Watts), a vivacious and vain London socialite. He proposes; she accepts (\"only to get as far away from [her] mother as possible\"), and the couple honeymoon in Venice. They travel on to Walter's medical post in Shanghai, where he is stationed in a government lab studying infectious diseases. They find themselves ill-suited, with Kitty much more interested in parties and the social life of the British expatriates. Kitty meets Charles Townsend (Liev Schreiber), a married British vice consul, and the two engage in a clandestine affair. When Walter discovers his wife's infidelity, he seeks to punish her by threatening to divorce her on the grounds of adultery, if she doesn't accompany him to a small village in a remote area of China. He has volunteered to treat victims of an unchecked cholera epidemic sweeping through the area. Kitty begs to be allowed to divorce him quietly, but he refuses, stating \"Why should I put myself through the smallest trouble for you?\" She hopes Townsend will leave his wife Dorothy and marry her. When she proposes this possibility to Charles, he declines to accept, despite earlier claiming to love Kitty. She is compelled to travel to the mountainous inland region with her husband. They embark upon an arduous, two-week-long overland journey, which would be considerably faster and much easier if they traveled by river, but Walter is determined to make Kitty as unhappy and uncomfortable as possible. Upon their arrival in Mei-tan-fu, she is distressed to discover they will be living in near squalor, far removed from everyone except their cheerful neighbor Waddington, a British deputy commissioner living with a young Chinese woman in relative opulence. Walter and Kitty barely speak to each other and, except for a cook and a Chinese soldier assigned to guard her, she is alone for long hours. After visiting an orphanage run by a group of French nuns, Kitty volunteers her services, and she is assigned to work in the music room. She is surprised to learn from the Mother Superior that her husband loves children, especially babies. In this setting, she begins to see him in a new light as she learns what a selfless and caring person he can be. When he sees her with the children, he in turn realizes she is not the shallow, selfish person he thought her to be. As Walter's anger and Kitty's unhappiness subside, their marriage begins to blossom in the midst of the epidemic crisis. She soon learns she is pregnant, but is unsure who the father is. Walter in love with Kitty again assures her it doesn't matter. The cholera epidemic takes many victims. As Walter and the locals are starting to get it under control, completely due to his importation of clean water through a system of aqueducts (as the local people did not understand water-borne infectious disease[2][bettersourceneeded]) cholera carrying refugees from elsewhere pour into the area, forcing Walter to set up a camp outside town. He contracts the disease and Kitty lovingly nurses him, but he dies, and she is devastated. Bereft and pregnant, she leaves China. Five years later, Kitty appears well-dressed and happy in London shopping with her young son Walter. They meet Townsend by chance on the street, and he suggests that Kitty meet with him. Asking young Walter his age, he realizes from the reply that he might have been the boy's father. Kitty rejects his overtures and walks away. When her son asks who Townsend is, she replies \"No one important, darling\".", "pos": "Marigold Lexton (Ali Larter), a self-centered and temperamental young American actress, arrives in India expecting to be treated like a star, despite the fact that she has been making nothing but B movie sequels for some time. She is stranded in Goa after the film she was to star in is canceled, and a sympathetic crew member offers her a ride, which brings her to the set of another movie, a Bollywood musical. She actually tells her boyfriend Barry that she was hoping she wouldn't have to marry him if this trip was successful, and soon finds herself the center of attraction on the set, where she quickly lands a minor role and a date with the spoiled young lead actor. But after she rebuffs his crude proposal that night she winds up talking with Prem (Salman Khan), the film's choreographer. He knows she lied about being able to dance, and takes her in hand, while showing her the nearby towns and countryside in their spare time. As they grow closer Prem talks to her about the importance of family, and she not only learns that he is estranged from his father, but that he is also a prince. He had not seen his family in three years, but the day before he received a call from his sister, asking him to come home for her wedding. He asks Marigold to go home with him to Jodhpur, Rajasthan, for the wedding, since shooting on the movie had been shut down for a week. She is entranced by the generosity and opulence of his family leading up to the wedding, but afterwards is shocked to discover that he has been betrothed to another since childhood. He has fallen totally in love with Marigold, but has neglected to mention the long arranged marriage, and his father has not encouraged him to follow his heart. She feels betrayed and storms out, followed by Prem's fiance, who offers to buy her a drink. She confesses to Marigold that although she loves Prem she doesn't believe he has ever really loved her. Meanwhile, Prem, a teetotaler, heads to a bar to drown his sorrows, where he finds a drunken American who commiserates with his romantic problems. He explains he has come looking for his estranged girlfiend, called Marigold, and Prem invites him to stay the night at his parents' house. Barry accepts and then passes out. In the morning, Marigold decides to return with Barry to the United States, since Prem, the only son of Jaipur's Ruler, feels duty bound to marry the woman his father has chosen. The ceremony takes place that day, and as he follows his bride, whose face is totally hidden behind a long veil, seven times around the Holy fire, Prem believes he is marrying the woman he has been engaged to since childhood. With the marriage complete, Prem lifts his wife's veil, and he and most of the guests are astonished to find Marigold standing before himand it appears that Barry has married Prem's former fiance as well. The movie's director and their friends from the crew appear in the crowd, cheering, then Prem sings and dances with Marigold and a full chorus, just like a happy ending in a Bollywood musical.", "neg": "Chettinad Palace in Karaikudi seen in the film. Natesan (Cheran) works as an engineer in electricity board in Karaikudi and leads a joint family with more 30 of his relatives living in the same house. On the other hand, Visalakshi aka Sala (Sneha) is the only daughter to her parents and she is about to complete her college education in Karaikudi. Sala feels bored while being alone and she always prefers to have her friends surrounding her. Sala's parents start searching for a groom and they get a reference for Natesan. Sala and her family meet Natesan's family in a function. Sala is surprised to see so many people living as a joint family together and she is very much impressed and agrees for the wedding. Natesan and Sala get married. Sala loves being accompanied by all the relatives in Natesan's home. When Sala and Natesan go on a honeymoon, Sala purchases gifts for everyone in the family. All the family members are also impressed seeing Sala. But Natesan feels sad that he does not get private time to spend with his wife as they are always surrounded by relatives. Now Natesan gets transferred to a hill station named Attakatti, near Pollachi. Natesan feels happy as he believes this will provide him time to spend with Sala. Although Sala feels sad leaving all her relatives, she also goes with Natesan to the hill station. Over there in the hill station, Sala feels lonely and gets bored and she longs for the life she had in Karaikudi. Their house is located in a remote place with no neighbours and friends. Natesan also gets busy with work and has very little time to spend with his wife. Slowly Sala gets psychologically disturbed due to loneliness and she behaves as if the house is filled with so many people. Also, she repairs the fan, lights etc. purposefully in their home so that the nearby electrician (Kanja Karuppu) comes to fix them and at least she gets a chance to speak to someone. She also starts recording all the sounds around her such as birds chirping, etc. and listens to the recordings when alone. One day, she records a neighbour's child's laughter sound following which the child faints. Sala is scared but the child is saved. Doctor Ramalingam (Jayaram) sees Sala and understands that she is suffering from a disorder and warns Natesan. But Natesan does not take it seriously. One day Sala consumes too much of sleeping pills to come out of her depression. But Natesan spots her lying in bed and rushes her to the hospital. Sala is saved. Ramalingam explains the disorder to Natesan and mentions that the best cure for her would be to lead a happy life surrounded by relatives. Natesan agrees and moves back to Karaikudi. The movie ends showing Natesan and Sala leading a happy life again.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}279{"query": "Hospitalization for exacerbation of COPD is associated with a high risk of mortality. A risk-prediction model using information easily obtained on admission could help to identify high-risk individuals. The CURB65 score was developed to predict mortality risk in community acquired pneumonia. A retrospective study found that this score was also associated with mortality in COPD exacerbations. We conducted a prospective study to assess the utility of the CURB65 score in acute COPD exacerbations. Consecutive patients with physician diagnosed COPD exacerbations admitted to a public hospital during a 1-year period were studied prospectively. The CURB65 scores were calculated from information obtained at initial hospital presentation. CURB65=one point each for Confusion, Urea>7 mmol/L, Respiratory rate30/min, low Blood pressure, age65 years. 30-day mortality data were available for 249 of 252 patients. CURB65 scores on admission significantly predicted risk of death during the hospital admission and at 30days. The 30-day mortality by score groups were: low risk (scores 0-1) 2.0% (2/98), moderate risk (score 2) 6.7% (6/90) and high risk (scores 3-5) 21.3% (13/61). CURB65 scores were not predictive of 1-year mortality. A simple 6-point score based on confusion, blood urea, respiratory rate, blood pressure and age can be used to stratify patients with COPD exacerbation into different management groups. The CURB65 score was as effective in predicting early mortality in our cohort of acute COPD exacerbations as it was in previous cohorts with community acquired pneumonia. Our findings suggest that CURB65 scores can help clinicians to assess patients with exacerbation of COPD.", "pos": "Community-acquired pneumonia (CAP) is a common cause of morbidity and mortality in adults worldwide, but its epidemiology varies markedly by region. Whilst in high-income countries, the predominant burden of CAP is in the elderly and those with chronic cardiovascular and pulmonary co-morbidity, CAP patients in low-income settings are often of working age and, in sub-Saharan Africa, frequently HIV-positive. Although region-specific aetiological data are limited, they are sufficient to highlight major trends: in high-burden settings, tuberculosis (TB) is a common cause of acute CAP; Gram-negative pathogens such as Klebsiella pneumoniae are regionally important; and HIV-associated opportunistic infections are common but difficult to diagnose. These differences in epidemiology and aetiological profile suggest that modified approaches to diagnosis, severity assessment and empirical antimicrobial therapy of CAP are necessary, but tailored individualized management approaches are constrained by limitations in the availability of radiological and laboratory diagnostic services, as well as medical expertise. The widespread introduction of the Xpert MTB/RIF platform represents a major advance for TB diagnosis, but innovations in rapid diagnostics for other opportunistic pathogens are urgently needed. Severity assessment tools (e.g. CURB65) that are used to guide early management decisions in CAP have not been widely validated in low-income settings and locally adapted tools are required. The optimal approach to initial antimicrobial therapy choices such as the need to provide early empirical cover for atypical bacteria and TB remain poorly defined. Improvements in supportive care such as correcting hypoxaemia and intravenous fluid management represent opportunities for substantial reductions in mortality.", "neg": "Dendritic cells (DCs), professional antigen-presenting cells with the unique ability to initiate primary T-cell responses, are present in atherosclerotic lesions where they are exposed to oxidative stress that generates cytotoxic reactive oxygen species (ROS). A large body of evidence indicates that cell death is a major modulating factor of atherogenesis. We examined antioxidant defence systems of human monocyte-derived (mo)DCs and monocytes in response to oxidative stress. Oxidative stress was induced by addition of tertiary-butylhydroperoxide (tert-BHP, 30 min). Cellular responses were evaluated using flow cytometry and confocal live cell imaging (both using 5-(and-6)-chloromethyl-2,7-dichlorodihydrofluorescein diacetate, CM-H(2)DCFDA). Viability was assessed by the neutral red assay. Total RNA was extracted for a PCR profiler array. Five genes were selected for confirmation by Taqman gene expression assays, and by immunoblotting or immunohistochemistry for protein levels. Tert-BHP increased CM-H(2)DCFDA fluorescence and caused cell death. Interestingly, all processes occurred more slowly in moDCs than in monocytes. The mRNA profiler array showed more than 2-fold differential expression of 32 oxidative stress-related genes in unstimulated moDCs, including peroxiredoxin-2 (PRDX2), an enzyme reducing hydrogen peroxide and lipid peroxides. PRDX2 upregulation was confirmed by Taqman assays, immunoblotting and immunohistochemistry. Silencing PRDX2 in moDCs by means of siRNA significantly increased CM-DCF fluorescence and cell death upon tert-BHP-stimulation. Our results indicate that moDCs exhibit higher intracellular antioxidant capacities, making them better equipped to resist oxidative stress than monocytes. Upregulation of PRDX2 is involved in the neutralization of ROS in moDCs. Taken together, this points to better survival skills of DCs in oxidative stress environments, such as atherosclerotic plaques.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}280{"query": "Telescopus hoogstraali, common names of which are Hoogstraal's cat snake and Sinai cat snake, is an endangered species of snake in the family Colubridae.", "pos": "The Anaspidoglanis boutchangai is considered to be of least concern to becoming an endangered species.", "neg": "''Down on Love'' was the fifth and final single taken from the album Agent Provocateur by the band Foreigner, and primarily released only in the U.S. in September 1985.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}281{"query": "Saith the Lord is a collection of a mystery story by author Howard Wandrei with a letter and a short autobiography.", "pos": "The Lump of Coal is a Christmas short story written by Lemony Snicket and illustrated by Brett Helquist.", "neg": "Chronicles of Avonlea is a collection of short stories by L. M. Montgomery, related to the Anne of Green Gables series.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}282{"query": "The Draco Dwarf is a spheroidal galaxy which was discovered by Albert George Wilson of Lowell Observatory in 1954 on photographic plates of the National Geographic Society's Palomar Observatory Sky Survey (POSS).", "pos": "The first astronomer to record the Butterfly Cluster's existence was Giovanni Battista Hodierna in 1654.", "neg": "Westerhout 43, also known as W43, is a region of star formation of our galaxy located in the constellation of Aquila at a distance of 6 kilo-parsecs (nearly 20,000 light-years) of the Sun, that is considered the region of the Milky Way that is most actively forming stars.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}283{"query": "The most widely accepted explanation of how the solar system formed is called the nebular hypothesis. According to this hypothesis, the Sun and the planets of our solar system formed about 4.6 billion years ago from the collapse of a giant cloud of gas and dust, called a nebula. The nebula was drawn together by gravity, which released gravitational potential energy. As small particles of dust and gas smashed together to create larger ones, they released kinetic energy. As the nebula collapsed, the gravity at the center increased and the cloud started to spin because of its angular momentum. As it collapsed further, the spinning got faster, much as an ice skater spins faster when he pulls his arms to his sides during a spin. Much of the clouds mass migrated to its center but the rest of the material flattened out in an enormous disk. The disk contained hydrogen and helium, along with heavier elements and even simple organic molecules. As gravity pulled matter into the center of the disk, the density and pressure at the center became intense. When the pressure in the center of the disk was high enough, nuclear fusion began. A star was bornthe Sun. The burning star stopped the disk from collapsing further. Meanwhile, the outer parts of the disk were cooling off. Matter condensed from the cloud and small pieces of dust started clumping together. These clumps collided and combined with other clumps. Larger clumps, called An artists painting of a protoplanetary disk. planetesimals, attracted smaller clumps with their gravity. Gravity at the center of the disk attracted heavier particles, such as rock and metal and lighter particles remained further out in the disk. Eventually, the planetesimals formed protoplanets, which grew to become the planets and moons that we find in our solar system today. Because of the gravitational sorting of material, the inner planets Mercury, Venus, Earth, and Mars formed from dense rock and metal. The outer planets Jupiter, Saturn, Uranus and Neptune condensed farther from the Sun from lighter materials such as hydrogen, helium, water, ammonia, and methane. Out by Jupiter and beyond, where its very cold, these materials form solid particles. The nebular hypothesis was designed to explain some of the basic features of the solar system: The orbits of the planets lie in nearly the same plane with the Sun at the center The planets revolve in the same direction The planets mostly rotate in the same direction The axes of rotation of the planets are mostly nearly perpendicular to the orbital plane The oldest moon rocks are 4.5 billion years Click image to the left or use the URL below. URL:", "pos": "Our solar system began about 5 billion years ago. The Sun, planets and other solar system objects all formed at about the same time. The Sun and planets formed from a giant cloud of gas and dust. This was the solar nebula. The cloud contracted and began to spin. As it contracted, its temperature and pressure increased. The cloud spun faster, and formed into a disk. Scientists think the solar system at that time looked like these disk-shaped objects in the Orion Nebula (Figure Temperatures and pressures at the center of the cloud were extreme. It was so hot that nuclear fusion reactions began. In these reactions hydrogen fuses to make helium. Extreme amounts of energy are released. Our Sun became a star! Material in the disk surrounding the Sun collided. Small particles collided and became rocks. Rocks collided and became boulders. Eventually planets formed from the material (Figure 12.2). Dwarf plants, comets, and asteroids formed too (Figure 12.3). Material at a similar distances from the Sun collided together to form each of the planets. Earth grew from material in its part of space. Moons origin was completely different from Earths. Earth formed like the other planets. Different materials in its region of space collided. Eventually the material made a planet. All of the collisions caused Earth to heat up. Rock and metal melted. The molten material separated into layers. Gravity pulled the denser material into the center. The lighter elements rose to the surface (Figure 12.4). Because the material separated, Earths core is made mostly of iron. Earths crust is made mostly of lighter materials. In between the crust and the core is Earths mantle, made of solid rock. This model for how the Moon formed is the best fit of all of the data scientists have about the Moon. In the early solar system there was a lot of space debris. Asteroids flew around, sometimes striking the planets. An asteroid the size of Mars smashed into Earth. The huge amount of energy from the impact melted most of Earth. The asteroid melted too. Material from both Earth and the asteroid was thrown out into orbit. Over time, this material smashed together to form our Moon. The lunar surface is about 4.5 billion years old. This means that the collision happened about 70 million years after Earth formed. An atmosphere is the gases that surround a planet. The early Earth had no atmosphere. Conditions were so hot that gases were not stable. Earths first atmosphere was different from the current one. The gases came from two sources. Volcanoes spewed gases into the air. Comets carried in ices from outer space. These ices warmed and became gases. Nitrogen, carbon dioxide, hydrogen, and water vapor, or water in gas form, were in the first atmosphere (Figure 12.5). Take a look at the list of gases. Whats missing? The early atmosphere had almost no oxygen. Earths atmosphere slowly cooled. Once it was cooler, water vapor could condense. It changed back to its liquid form. Liquid water could fall to Earths surface as rain. Over millions of years water collected to form the oceans. Water began to cycle on Earth as water evaporated from the oceans and returned again as rainfall.", "neg": "Earth formed at the same time as the other planets. The history of Earth is part of the history of the Solar System. Earth came together (accreted) from the cloud of dust and gas known as the solar nebula nearly 4.6 billion years ago, the same time the Sun and the rest of the solar system formed. Gravity caused small bodies of rock and metal orbiting the proto-Sun to smash together to create larger bodies. Over time, the planetoids got larger and larger until they became planets. When Earth first came together it was really hot, hot enough to melt the metal elements that it contained. Earth was so hot for three reasons: Gravitational contraction: As small bodies of rock and metal accreted, the planet grew larger and more massive. Gravity within such an enormous body squeezes the material in its interior so hard that the pressure swells. As Earths internal pressure grew, its temperature also rose. Radioactive decay: Radioactive decay releases heat, and early in the planets history there were many ra- dioactive elements with short half lives. These elements long ago decayed into stable materials, but they were responsible for the release of enormous amounts of heat in the beginning. Bombardment: Ancient impact craters found on the Moon and inner planets indicate that asteroid impacts were common in the early solar system. Earth was struck so much in its first 500 million years that the heat was intense. Very few large objects have struck the planet in the past many hundreds of millions of year. When Earth was entirely molten, gravity drew denser elements to the center and lighter elements rose to the surface. The separation of Earth into layers based on density is known as differentiation. The densest material moved to the center to create the planets dense metallic core. Materials that are intermediate in density became part of the mantle (Figure 1.1). Lighter materials accumulated at the surface of the mantle to become the earliest crust. The first crust was probably basaltic, like the oceanic crust is today. Intense heat from the early core drove rapid and vigorous mantle convection so that crust quickly recycled into the mantle. The recycling of basaltic crust was so effective that no remnants of it are found today. There is not much material to let us know about the earliest days of our planet Earth. What there is comes from three sources: (1) zircon crystals, the oldest materials found on Earth, which show that the age of the earliest crust formed at least 4.4 billion years ago; (2) meteorites that date from the beginning of the solar system, to nearly 4.6 billion years ago (Figure 1.2); and (3) lunar rocks, which represent the early days of the Earth-Moon system as far back as 4.5 billion years ago.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}284{"query": "Fungi (fungus, singular) are relatively simple eukaryotic organisms. They are placed in their own kingdom, the Fungus Kingdom. Most fungi are multicellular organisms. These fungi are called molds. However, some fungi exist as single cells. These fungi are called yeasts. You can see examples of different types of fungi in Figure 9.7. For a funny, fast-paced overview of fungi, watch this video: . MEDIA Click image to the left or use the URL below. URL: For a long time, scientists classified fungi as members of the Plant Kingdom. Fungi share several obvious traits with plants. For example, both fungi and plants lack the ability to move. Both grow in soil, and both have cell walls. Some fungi even look like plants. Today, fungi are no longer classified as plants. We now know that they have important traits that set them apart from plants. Thats why they are placed in their own kingdom. How do fungi differ from plants? The cell walls of fungi are made of chitin. Chitin is a tough carbohydrate that also makes up the outer skeleton of insects. The cell walls of plants are made of cellulose. Fungi are heterotrophs that absorb food from other organisms. Plants are autotrophs that make their own food. The Fungus Kingdom is large and diverse. It may contain more than a million species. However, fewer than 100,000 species of fungi have been identified. The earliest fungi evolved about 600 million years ago. They lived in the water. Fungi colonized the land around the same time as plants. That was probably between 400 and 500 million years ago. After that, fungi became very abundant on land. By 250 million years ago, they may have been the dominant life forms on land. Yeasts grow as single cells. Other fungi grow into multicellular, thread-like structures. These structures are called hyphae (hypha, singular). You can see a photo of hyphae in Figure 9.8. They resemble plant roots. Each hypha consists of a group of cells surrounded by a tubular cell wall. A mass of hyphae make up the body of a fungus. The body is called the mycelium (mycelia, plural). A mycelium may range in size from microscopic to very large. In fact, the largest living thing on Earth is the mycelium of a single fungus. Nicknamed the humongous fungus, it grows in a forest in Oregon. A small part of the fungus is pictured in Figure 9.9. The giant fungus covers an area of 2384 acres. Thats about the size of 1,665 football fields! The fungus is estimated to be at least 2400 years old, but it could be much older. Most fungi reproduce both asexually and sexually. In both types of reproduction, they produce spores. A spore is a special reproductive cell. When fungi reproduce asexually, they can spread quickly. This is good when conditions are stable. They can increase their genetic variation by sexual reproduction. This is beneficial when conditions are changing. Variation helps ensure that at least some organisms survive the changing conditions. Figure 9.10 shows how asexual and sexual reproduction occur in fungi. Refer to the figure as you read about each of them below. During asexual reproduction, fungi produce haploid spores by mitosis of a haploid parent cell. A haploid cell has just one of each pair of chromosomes. The haploid spores are genetically identical to the parent cell. Spores may be spread by moving water, wind, or other organisms. Wherever the spores land, they will develop into new hyphae only when conditions are suitable for growth. Yeasts are an exception. They reproduce asexually by budding instead of by producing spores. An offspring cell forms on a parent cell. After it grows and develops, it buds off to form a new cell. The offspring cell is genetically identical to the parent cell. You can see yeast cells budding in Figure 9.11. Sexual reproduction also occurs in most fungi. It happens when two haploid hyphae mate. During mating, two haploid parent cells fuse. The single fused cell that results is a diploid spore. It is genetically different from both parents.", "pos": "The most important body parts of fungi include: 1. Cell wall: A layer around the cell membrane of fungi cells made largely of chitin and other polysaccharides. It is similar to that found in plant cells, though the plant cell wall contains the polysaccharide cellulose. 2. Hyphae: These are thread-like strands which interconnect and bunch up into a mycelium ( Figure 1.1). Ever see mold on a damp wall or on old bread? The things that you are seeing are really mycelia. The hyphae and mycelia help the fungi absorb nutrients from other organisms. Most of the mycelium is hidden from view deep within the fungal food source, such as rotting matter in the soil, leaf litter, rotting wood, or dead animals. Fungi produce enzymes to digest cellulose and various other materials found in rotting matter, helping with the decaying process. 3. Specialized structures for reproduction: One example is a fruiting body. Just like a fruit is involved in the reproduction of a fruiting plant, a fruiting body is involved in the reproduction of a fungus. A mushroom is a fruiting body, which is the part of the fungus that produces spores ( Figure 1.2). The spores are the basic reproductive units of fungi. The mycelium remains hidden until it develops one or more fruiting bodies. The fruiting bodies are usually produced at the surface of the food source, rather than hidden within it. This allows the reproductive spores to be easily shed and carried away by the wind, water, or animals. The fruiting bodies are usually the only indication that a fungus is present. Like icebergs, the fruiting bodies represent only a tiny fraction of the whole fungus, with most of the fungus hidden from view. Hyphae of a Penicillium mold. The little trees are specialized hyphae on which spores are produced. A mushroom is a fruiting body.", "neg": "There are two basic types of cells, prokaryotic cells and eukaryotic cells. The main difference between eukaryotic and prokaryotic cells is that eukaryotic cells have a nucleus. The nucleus is where cells store their DNA, which is the genetic material. The nucleus is surrounded by a membrane. Prokaryotic cells do not have a nucleus. Instead, their DNA floats around inside the cell. Organisms with prokaryotic cells are called prokaryotes. All prokaryotes are single-celled (unicellular) organisms. Bacteria and Archaea are the only prokaryotes. Organisms with eukaryotic cells are called eukaryotes. Animals, plants, fungi, and protists are eukaryotes. All multicellular organisms are eukaryotes. Eukaryotes may also be single-celled. Both prokaryotic and eukaryotic cells have structures in common. All cells have a plasma membrane, ribosomes, cytoplasm, and DNA. The plasma membrane, or cell membrane, is the phospholipid layer that surrounds the cell and protects it from the outside environment. Ribosomes are the non-membrane bound organelles where proteins are made, a process called protein synthesis. The cytoplasm is all the contents of the cell inside the cell membrane, not including the nucleus. Eukaryotic cells usually have multiple chromosomes, composed of DNA and protein. Some eukaryotic species have just a few chromosomes, others have close to 100 or more. These chromosomes are protected within the nucleus. In addition to a nucleus, eukaryotic cells include other membrane-bound structures called organelles. Organelles allow eukaryotic cells to be more specialized than prokaryotic cells. Pictured below are the organelles of eukaryotic cells ( Figure 1.1), including the mitochondria, endoplasmic reticulum, and Golgi apparatus. These will be discussed in additional concepts. DNA (chromatin) is stored. Organelles give eukaryotic cells more functions than prokaryotic cells. Prokaryotic cells ( Figure 1.2) are usually smaller and simpler than eukaryotic cells. They do not have a nucleus or other membrane-bound organelles. In prokaryotic cells, the DNA, or genetic material, forms a single large circle that coils up on itself. The DNA is located in the main part of the cell. Nucleus DNA Membrane-Bound Organelles Examples Prokaryotic Cells No Single circular piece of DNA No Bacteria Eukaryotic Cells Yes Multiple chromosomes Yes Plants, animals, fungi", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}285{"query": "Leon Lemmens (born March 16, 1954 in Boorsem, Maasmechelen, Belgium) is a Roman Catholic auxiliary bishop in Belgium.", "pos": "Melchior von Meckau (1440--1509) (called the Cardinal of Brixen) was a German Roman Catholic cardinal and bishop.", "neg": "The Besbre is a river in central France, left tributary of the river Loire.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}286{"query": "There is no consensus about mechanisms underlying restless legs syndrome (RLS), also known as Willis-Ekbom disease (WED). Cortical excitability may be abnormal in RLS. Transcranial magnetic stimulation (TMS) can provide insight about cortical excitability. We reviewed studies about measures of excitability to TMS in RLS. Original studies published between January 1999 and January 2015 were searched in PubMed, Scopus, and Web of Science databases. Inclusion criteria were as follows: original studies involving primary RLS in patients from both sexes and ages between 18 and 85 years; TMS protocols clearly described; and they were written in English, in peer-reviewed journals. Fifteen manuscripts were identified. TMS protocols were heterogeneous across studies. Resting motor threshold, active motor threshold, and amplitudes of motor-evoked potentials were typically reported to be normal in RLS. A reduction in short-interval intracortical inhibition (SICI) was the most consistent finding, whereas conflicting results were described in regard to short-interval intracortical facilitation and the contralateral silent period. Decreased SICI can be reversed by treatment with dopaminergic agonists. Plasticity in the motor cortex and sensorimotor integration may be disrupted. TMS may become a useful biomarker of responsiveness to drug treatment in RLS. The field can benefit from increases in homogeneity and sizes of samples, as well as from decrease in methodological variability across studies.", "pos": "Restless legs syndrome, now called Willis-Ekbom Disease (RLS/WED), is a sensorimotor-related sleep disorder. Little is known of the effect of RLS/WED on motor function. The current study investigated upper limb function in RLS/WED patients. We hypothesised that RLS/WED patients exhibit subtle changes in tremor amplitude but normal dexterity and movement speed and rhythmicity compared to healthy controls. RLS/WED patients (n=17, 59 7 years) with moderate disease and healthy controls (n=17, 58 6 years) completed screening tests and five tasks including object manipulation, maximal pinch grip, flexion and extension of the index finger (tremor assessment), maximal finger tapping (movement speed and rhythmicity assessment), and the grooved pegboard test. Force, acceleration, and/or first dorsal interosseus EMG were recorded during four of the tasks. Task performance did not differ between groups. Learning was evident on tasks with repeated trials and the magnitude of learning did not differ between groups. Hand function, tremor, and task learning were unaffected in RLS/WED patients. Patients manipulated objects in a normal manner and exhibited normal movement speed, rhythmicity, and tremor. Further research is needed to assess other types of movement in RLS/WED patients to gain insight into the motor circuitry affected and the underlying pathophysiology.", "neg": "To investigate whether the effects of nerve growth factor (NGF) inhibition with tanezumab on rats with medial meniscal tear (MMT) effectively model rapidly progressive osteoarthritis (RPOA) observed in clinical trials. Male Lewis rats underwent MMT surgery and were treated weekly with tanezumab (0.1, 1 or 10mg/kg), isotype control or vehicle for 7, 14 or 28days. Gait deficiency was measured to assess weight-bearing on the operated limb. Joint damage was assessed via histopathology. A second arm, delayed onset of treatment (starting 3-8weeks after MMT surgery) was used to control for analgesia early in the disease process. A third arm, mid-tibial amputation, evaluated the dependency of the model on weight-bearing. Gait deficiency in untreated rats was present 3-7days after MMT surgery, with a return to normal weight-bearing by days 14-28. Prophylactic treatment with tanezumab prevented gait deficiency and resulted in more severe cartilage damage. When onset of treatment with tanezumab was delayed to 3-8weeks after MMT surgery, there was no increase in cartilage damage. Mid-tibial amputation completely prevented cartilage damage in untreated MMT rats. These data suggest that analgesia due to NGF inhibition during the acute injury phase is responsible for increased voluntary weight-bearing and subsequent cartilage damage in the rat MMT model. This model failed to replicate the hypotrophic bone response observed in tanezumab-treated patients with RPOA.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}287{"query": "The current methods available to detect chromosomal abnormalities from DNA microarray expression data are cumbersome and inflexible. CAFE has been developed to alleviate these issues. It is implemented as an R package that analyzes Affymetrix *.CEL files and comes with flexible plotting functions, easing visualization of chromosomal abnormalities. CAFE is available from [Link] as both source and compiled packages for Linux and Windows. It is released under the GPL version 3 license. CAFE will also be freely available from Bioconductor. sander.h.bollen@gmail.com or nancy.mah@mdc-berlin.de Supplementary data are available at Bioinformatics online.", "pos": "Species-specific sets of chromosomes-karyotypes-are traditionally depicted as linear ideograms with individual chromosomes represented by vertical bars. However, linear visualization has its limitations when the shared collinearity and/or chromosomal rearrangements differentiating two or more karyotypes need to be demonstrated. In these instances, circular visualization might provide easier comprehension and interpretation of inter-species chromosomal collinearity. The chromDraw graphical tool was developed as a user-friendly graphical tool for visualizing both linear and circular karyotypes based on the same input data matrix. The output graphics, saved in two different formats (EPS and SVG), can be easily imported to and modified in presentation and image-editing computer programs. The tool is freely distributed under GNU General Public License (GPL) and can be installed from Bioconductor or from the chromDraw home page.", "neg": "The complex expression patterns observed for many genes are often regulated by distal transcription enhancers. Changes in the nucleotide sequences of enhancers may therefore lead to changes in gene expression, representing a central mechanism by which organisms evolve. With the development of the experimental technique of chromatin immunoprecipitation (ChIP), in which discrete regions of the genome bound by specific proteins can be identified, it is now possible to identify transcription factor binding events (putative cis-regulatory elements) in entire genomes. Comparing protein-DNA binding maps allows us, for the first time, to attempt to identify regulatory differences and infer global patterns of change in gene expression across species. Here, we review studies that used genome-wide ChIP to study the evolution of enhancers. The trend is one of high divergence of cis-regulatory elements between species, possibly compensated by extensive creation and loss of regulatory elements and rewiring of their target genes. We speculate on the meaning of the differences observed and discuss that although ChIP experiments identify the biochemical event of protein-DNA interaction, it cannot determine whether the event results in a biological function, and therefore more studies are required to establish the effect of divergence of binding events on species-specific gene expression.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}288{"query": "The Packers' offense struggled for the first half against the Seahawks. On the Packers' first drive, Aaron Rodgers threw an interception that was returned for a touchdown, but an illegal block in the back penalty negated the score. Before that play Rodgers had gone his previous 251 regular season pass attempts without an interception, a career high. The Packers' defense held Seattle in check but trailed 3-0 at halftime. In the third quarter, Mike Daniels forced a fumble that Green Bay recovered at the Seattle 6-yard line, and Ty Montgomery ran in for a touchdown on the following play, giving the Packers a lead they wouldn't relinquish after that. Later Rodgers caught the Seahawks with 12 men on the field and capitalized on the free play by throwing a 32-yard touchdown to Jordy Nelson. The Packers only surrendered two field goals to Seattle for the rest of the game, giving a strong defensive showing in the season opener.", "pos": "The Broncos' defense limited the Chiefs to 279 total yards 133 of which went to tight end Travis Kelce. However, the Broncos were unable to overcome five turnovers, including three interceptions by quarterback Trevor Siemian, as well as a fumble by running back Jamaal Charles that resulted in a Chiefs' touchdown. After trailing 20-3 early in the third quarter, the Broncos narrowed the Chiefs' lead to 20-13, following a 6-yard touchdown by running back Devontae Booker. However, three fourth-quarter field goals by Chiefs' placekicker Harrison Butker the latter two of which occurred after a Broncos' turnover on downs and Siemian's third interception of the game, increased the Chiefs' lead to 29-13. With 4:41 remaining in the game, the Broncos' attempted a rally, with Siemian connecting on an 11-yard touchdown pass to tight end A. J. Derby at the two-minute warning. However, the two-point conversion attempt was unsuccessful, which would have brought the Broncos' to within a one-score deficit, ending the Broncos' rally attempt. This was Jamaal Charles' first game against the Chiefs, for whom he played the first nine seasons of his career.", "neg": "Coming off huge home wins against the 49ers and Steelers, the Seahawks traveled to Minneapolis to take on the Minnesota Vikings. Despite being without both Marshawn Lynch and Jimmy Graham, the Seahawks dominated the Vikings 38-7. Going into the game, the Vikings were previously 8-3 and leading the NFC North, led the NFL in team rushing yards, and Adrian Peterson was the NFL's leading rusher. The Seahawks defense held Peterson to only 18 yards and the Vikings' offense failed to score (their only points coming on a special-teams kickoff return), while Russell Wilson and the Seattle offense racked up 433 yards, five total touchdowns, and no interceptions.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}289{"query": "''Belly Full of Turkey'' is the ninth episode in the first season of the television series How I Met Your Mother.", "pos": "''Nothing Good Happens After 2 A.M.'' is the 18th episode in the first season of the television series How I Met Your Mother.", "neg": "Menpehtyre Ramesses I (traditional English: Ramesses or Ramses) was the founding pharaoh of ancient Egypt's 19th dynasty.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}290{"query": "The endocrine system is a system of glands that release chemical messenger molecules into the blood stream. The messenger molecules are called hormones. Hormones act slowly compared with the rapid transmission of electrical impulses of the nervous system. Endocrine hormones must travel through the bloodstream to the cells they control, and this takes time. On the other hand, because endocrine hormones are released into the bloodstream, they travel to cells everywhere in the body. For a good visual introduction to the endocrine system, watch this short video: http MEDIA Click image to the left or use the URL below. URL: An endocrine gland is a gland that secretes hormones into the bloodstream for transport around the body (instead of secreting hormones locally, like sweat glands in the skin). Major glands of the endocrine system are shown in Figure 20.17. The glands are the same in males and females except for the ovaries and testes. The hypothalamus is actually part of the brain, but it also secretes hormones. Some of its hormones go directly to the pituitary gland in the endocrine system. These hypothalamus hormones tell the pituitary to either secrete or stop secreting its hormones. In this way, the hypothalamus provides a link between the nervous and endocrine systems. The hypothalamus also produces hormones that directly regulate body processes. For example, it produces antid- iuretic hormone. This hormone travels to the kidneys and stimulates them to conserve water by producing more concentrated urine. The pea-sized pituitary gland is just below the hypothalamus and attached directly to it. The pituitary receives hormones from the hypothalamus. It also secretes its own hormones. Most pituitary hormones control other endocrine glands. Thats why the pituitary gland is called the master gland of the endocrine system. Table Pituitary Hormone Adrenocorticotropic (ACTH) hormone Target Glands/Cells adrenal glands Thyroid-stimulating (TSH) Growth hormone (GH) hormone thyroid gland Follicle-stimulating (FSH) hormone body cells ovaries or testes Luteinizing hormone (LH) ovaries or testes Prolactin (PRL) mammary glands Effects(s) Stimulates the cortex (outer layer) of the adrenal glands to secrete their hormones Stimulates the thyroid gland to se- crete its hormones Stimulates body cells to make pro- teins and grow Stimulates the ovaries to develop mature eggs; stimulates the testes to produce sperm Stimulates the ovaries or testes to secrete sex hormones; stimulates the ovaries to release eggs Stimulates the mammary glands to produce milk There are several other endocrine glands. Find them in Figure 20.17 as you read about them below. The thyroid gland is a relatively large gland in the neck. Hormones secreted by the thyroid gland include thyroxin. Thyroxin increases the rate of metabolism in cells throughout the body. The pancreas is a large gland located near the stomach. Hormones secreted by the pancreas include insulin. Insulin helps cells absorb glucose from the blood. It also stimulates the liver to take up and store excess glucose. The two adrenal glands are glands located just above the kidneys. Each adrenal gland has an outer layer (cortex) and inner layer (medulla) that secrete different hormones. The hormone adrenaline is secreted by the inner layer. It prepares the body to respond to emergencies. For example, it increases the amount of oxygen and glucose going to the muscles. The gonads are glands that secrete sex hormones. Male gonads are called testes. They secrete the male sex hormone testosterone. The female gonads are called ovaries. They secrete the female sex hormone estrogen. Sex hormones stimulate the changes of puberty. They also control the production of sperm or eggs by the gonads. Endocrine hormones travel throughout the body in the blood. However, each endocrine hormone affects only certain cells, called target cells. A target cell is the type of cell on which a given endocrine hormone has an effect. A target cell is affected by a given hormone because it has proteins on its surface to which the hormone can bind. When the hormone binds to target cell proteins, it causes changes inside the cell. For example, binding of the hormone might cause the release of enzymes inside the cell. The enzymes then influence cell processes. Endocrine hormones control many cell activities, so they are very important for homeostasis.", "pos": "Two functions of the female reproductive system are similar to the functions of the male reproductive system: producing gametes and secreting a major sex hormone. In the case of females, however, the gametes are eggs, and they are produced by the ovaries. The hormone is estrogen, which is the main sex hormone in females. Estrogen has two major roles: During adolescence, estrogen causes the changes of puberty. It causes the reproductive organs to mature. It also causes other female traits to develop. For example, it causes the breasts to grow and the hips to widen. During adulthood, estrogen is needed for a woman to release eggs from the ovaries. The female reproductive system has another important function, which is not found in males. It supports a baby as it develops before birth. It also gives birth to the baby at the end of pregnancy. The female reproductive organs include the ovaries, fallopian tubes, uterus, and vagina. These organs are shown in Figure 22.3, along with some other structures of the female reproductive system. Find each organ in the drawing as you read about it below. For a cartoon about the female reproductive system, watch this video: [Link] The two ovaries are small, oval organs on either side of the abdomen. Each ovary contains thousands of eggs. However, the eggs do not develop fully until a female has gone through puberty. Then, about once a month, an egg is released by one of the ovaries. The ovaries also secrete estrogen. The two fallopian tubes are thin tubes that are connected to the uterus and extend almost to the ovaries. The upper end of each fallopian tube has fingers (called fimbriae) that sweep an egg into the fallopian tube when it is released by the ovary. The egg then passes through the fallopian tube to the uterus. If an egg is fertilized, this occurs in the fallopian tube. The uterus is a hollow organ with muscular walls. The uterus is where a baby develops until birth. The walls of the uterus stretch to accommodate the growing fetus. The muscles in the walls contract to push the baby out during birth. The uterus is connected to the vagina by a small opening called the cervix. The vagina is a cylinder-shaped organ that opens to the outside of the body. The other end joins with the uterus. Sperm deposited in the vagina swim up through the cervix, into the uterus, and from there into a When a baby girl is born, her ovaries contain all of the eggs they will ever produce. But these eggs are not fully developed. They develop only after the female reaches puberty at about age 12 or 13. Then, just one egg develops each month until she reaches her 40s or early 50s. Human eggs are very large cells. In fact, they are the largest of all human cells. You can even see an egg without a microscope. Its almost as big as the period at the end of this sentence. Like a sperm cell, an egg cell is a haploid cell with half the number of chromosomes of other cells in the body. Unlike a sperm cell, the egg lacks a tail and contains a lot of cytoplasm. Egg production takes place in the ovaries. It occurs in several steps: 1. Before birth, special cells in the ovaries go through mitosis to make identical daughter cells. 2. The daughter cells then start to divide by meiosis. However, they go though only the first of the two cell divisions of meiosis at this time. They remain in that stage until the girl goes through puberty. 3. After puberty, an egg develops in an ovary about once a month. As you can see in Figure 22.4, the egg rests in a nest of cells called a follicle. The follicle and egg grow larger and go through other changes. 4. After a couple of weeks, the egg bursts out of the follicle and through the wall of the ovary. This is called ovulation. After ovulation occurs, the moving fingers of the nearby fallopian tube sweep the egg into the tube. Fertilization may occur if sperm reach the egg while it is", "neg": "The main chemical components of living organisms are known as organic compounds. Organic compounds are molecules built around the element carbon (C). Living things are made up of very large molecules. These large molecules are called macromolecules because macro means large; they are made by smaller molecules bonding together. Our body gets these smaller molecules, the \"building blocks\" or monomers, of organic molecules from the food we eat. Which organic molecules do you recognize from the list below? The four main types of macromolecules found in living organisms, shown in Table 1.1, are: 1. 2. 3. 4. Proteins. Carbohydrates. Lipids. Nucleic Acids. Proteins C, H, O, N, S Enzymes, muscle fibers, antibodies Elements Examples Monomer building molecule) (small block Amino acids Carbohydrates C, H, O Sugar, glucose, starch, glycogen, cellulose Monosaccharides (simple sugars) Lipids C, H, O, P Fats, oils, waxes, steroids, phospho- lipids in membranes Often include fatty acids Nucleic Acids C, H, O, P, N DNA, RNA, ATP Nucleotides Carbohydrates are sugars, or long chains of sugars. An important role of carbohydrates is to store energy. Glucose ( Figure 1.1) is an important simple sugar molecule with the chemical formula C6 H12 O6 . Simple sugars are known as monosaccharides. Carbohydrates also include long chains of connected sugar molecules. These long chains often consist of hundreds or thousands of monosaccharides bonded together to form polysaccharides. Plants store sugar in polysaccharides called starch. Animals store sugar in polysaccharides called glycogen. You get the carbohydrates you need for energy from eating carbohydrate-rich foods, including fruits and vegetables, as well as grains, such as bread, rice, or corn. A molecule of glucose, a type of carbohy- drate. Proteins are molecules that have many different functions in living things. All proteins are made of monomers called amino acids ( Figure 1.2) that connect together like beads on a necklace ( Figure 1.3). There are only 20 common amino acids needed to build proteins. These amino acids form in thousands of different combinations, making about 100,000 or more unique proteins in humans. Proteins can differ in both the number and order of amino acids. It is the number and order of amino acids that determines the shape of the protein, and it is the shape (structure) of the protein that determines the unique function of the protein. Small proteins have just a few hundred amino acids. The largest proteins have more than 25,000 amino acids. This model shows the general structure of all amino acids. Only the side chain, R, varies from one amino acid to another. KEY: H = hydrogen, N = nitrogen, C = carbon, O = oxygen, R = variable side chain. Many important molecules in your body are proteins. Examples include enzymes, antibodies, and muscle fiber. Enzymes are a type of protein that speed up chemical reactions. They are known as \"biological catalysts.\" For example, your stomach would not be able to break down food if it did not have special enzymes to speed up the rate of digestion. Antibodies that protect you against disease are proteins. Muscle fiber is mostly protein ( Figure 1.4). Muscle fibers are made mostly of protein. Its important for you and other animals to eat food with protein, because we cannot make certain amino acids on our own. You can get proteins from plant sources, such as beans, and from animal sources, like milk or meat. When you eat food with protein, your body breaks the proteins down into individual amino acids and uses them to build new proteins. You really are what you eat! Have you ever tried to put oil in water? They dont mix. Oil is a type of lipid. Lipids are molecules such as fats, oils, and waxes. The most common lipids in your diet are probably fats and oils. Fats are solid at room temperature, whereas oils are fluid. Animals use fats for long-term energy storage and to keep warm. Plants use oils for long- term energy storage. When preparing food", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}291{"query": "Histone variant H2A.Z-containing nucleosomes exist at most eukaryotic promoters and play important roles in gene transcription and genome stability. The multisubunit nucleosome-remodeling enzyme complex SWR1, conserved from yeast to mammals, catalyzes the ATP-dependent replacement of histone H2A in canonical nucleosomes with H2A.Z. How SWR1 catalyzes the replacement reaction is largely unknown. Here, we determined the crystal structure of the N-terminal region (599-627) of the catalytic subunit Swr1, termed Swr1-Z domain, in complex with the H2A.Z-H2B dimer at 1.78 A resolution. The Swr1-Z domain forms a 310 helix and an irregular chain. A conserved LxxLF motif in the Swr1-Z 310 helix specifically recognizes the C helix of H2A.Z. Our results show that the Swr1-Z domain can deliver the H2A.Z-H2B dimer to the DNA-(H3-H4)2 tetrasome to form the nucleosome by a histone chaperone mechanism.", "pos": "The evolutionarily conserved histone variant H2A.Z has an important role in the regulation of gene expression and the establishment of a buffer to the spread of silent heterochromatin. Saccharomyces cerevisiae Swr1, a Swi2/Snf2-related ATPase, is the catalytic core of a multisubunit chromatin remodeling enzyme, called the SWR1 complex, that efficiently replaces conventional histone H2A in nucleosomes with histone H2A.Z. Swr1 is required for the deposition of histone H2A.Z at stereotypical promoter locations in vivo, and Swr1 and H2A.Z commonly regulate a subset of yeast genes. Here, we describe an integrated nucleosome assembly-histone replacement system whereby histone exchange by chromatin remodeling activities may be analyzed in vitro. The system demonstrates ATP- and SWR1-complex-dependent replacement of histone H2A for histone H2A.Z on a preassembled nucleosome array. This system may also be adapted to analyze dynamic interactions between chromatin remodeling and modifying enzymes, histone chaperones, and nucleosome substrates containing canonical, variant, or covalently modified histones.", "neg": "The methylation of lysine residues of histones plays a pivotal role in the regulation of chromatin structure and gene expression. Here, we report two crystal structures of SET7/9, a histone methyltransferase (HMTase) that transfers methyl groups to Lys4 of histone H3, in complex with S-adenosyl-L-methionine (AdoMet) determined at 1.7 and 2.3 A resolution. The structures reveal an active site consisting of: (i) a binding pocket between the SET domain and a c-SET helix where an AdoMet molecule in an unusual conformation binds; (ii) a narrow substrate-specific channel that only unmethylated lysine residues can access; and (iii) a catalytic tyrosine residue. The methyl group of AdoMet is directed to the narrow channel where a substrate lysine enters from the opposite side. We demonstrate that SET7/9 can transfer two but not three methyl groups to unmodified Lys4 of H3 without substrate dissociation. The unusual features of the SET domain-containing HMTase discriminate between the un- and methylated lysine substrate, and the methylation sites for the histone H3 tail.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}292{"query": "The Green Revolution has brought enormous impacts to the planet. Natural landscapes have been altered to create farmland and cities. Already, half of the ice-free lands have been converted to human uses. Estimates are that by 2030, that number will be more than 70%. Forests and other landscapes have been cleared for farming or urban areas. Rivers have been dammed and the water is transported by canals for irrigation and domestic uses. Ecologically sensitive areas have been altered: wetlands are now drained and coastlines are developed. Modern agricultural practices produce a lot of pollution (Figure 1.1). Some pesticides are toxic. Dead zones grow as fertilizers drain off farmland and introduce nutrients into lakes and coastal areas. Farm machines and vehicles used to transport crops produce air pollutants. Pollutants enter the air, water, or are spilled onto the land. Moreover, many types of pollution easily move between air, water, and land. As a result, no location or organism not even polar bears in the remote Arctic is free from pollution. The increased numbers of people have other impacts on the planet. Humans do not just need food. They also need clean water, secure shelter, and a safe place for their wastes. These needs are met to different degrees in different nations and among different socioeconomic classes of people. For example, about 1.2 billion of the worlds people do not have enough clean water for drinking and washing each day (Figure 1.2). The addition of more people has not just resulted in more poor people. A large percentage of people expect much more than to have their basic needs met. For about one-quarter of people there is an abundance of food, plenty of water, and a secure home. Comfortable temperatures are made possible by heating and cooling systems, rapid trans- portation is available by motor vehicles or a well-developed public transportation system, instant communication takes place by phones and email, and many other luxuries are available that were not even dreamed of only a few The percentage of people in the world that live in abject poverty is decreasing some- what globally, but increasing in some re- gions, such as Sub-Saharan Africa. decades ago. All of these require resources in order to be produced, and fossil fuels in order to be powered (Figure Many people refer to the abundance of luxury items in these peoples lives as over-consumption. People in developed nations use 32 times more resources than people in the developing countries of the world. Click image to the left or use the URL below. URL: Click image to the left or use the URL below. URL:", "pos": "Air quality is a measure of the pollutants in the air. More pollutants mean poorer air quality. Air quality, in turn, depends on many factors. Some natural processes add pollutants to the air. For example, forest fires and volcanoes add carbon dioxide and soot. In dry areas, the air often contains dust. However, human actions cause the most air pollution. The single biggest cause is fossil fuel burning. Poor air quality started to become a serious problem after the Industrial Revolution. The machines in factories burned coal. This released a lot of pollutants into the air. After 1900, motor vehicles became common. Cars and trucks burn gasoline, which adds greatly to air pollution. By the mid-1900s, air quality in many big cities was very bad. The worst incident came in December 1952. A temperature inversion over London, England, kept cold air and pollutants near the ground. The air became so polluted that thousands of people died in just a few days. This event was called the Big Smoke. At the same time, many U.S. cities had air pollution problems. Some of the worst were in California. Cars were becoming more popular. Oil refineries and power plants also polluted the air. Mountain ranges trapped polluted air over cities. The California sunshine caused chemical reactions among the pollutants. These reactions produced many more harmful compounds. By 1970, it was clear that something needed to be done to protect air quality. In the U.S., the Clean Air Act was passed. It limits what can be released into the air. As a result, the air in the U.S. is much cleaner now than it was 50 years ago. But air pollution has not gone away. Vehicles, factories, and power plants still release more than 150 million tons of pollutants into the air each year. There are two basic types of pollutants in air. They are known as primary pollutants and secondary pollutants. Primary pollutants enter the air directly. Some are released by natural processes, like ash from volcanoes. Most are released by human activities. They pour into the air from vehicles and smokestacks. Several of these pollutants are described below. Carbon oxides include carbon monoxide (CO) and carbon dioxide (CO2 ). Carbon oxides are released when fossil fuels burn. Nitrogen oxides include nitric oxide (NO) and nitrogen dioxide (NO2 ). Nitrogen oxides form when nitrogen and oxygen combine at high temperatures. This occurs in hot exhausts from vehicles, factories, and power plants. Sulfur oxides include sulfur dioxide (SO2 ) and sulfur trioxide (SO3 ). Sulfur oxides are produced when sulfur and oxygen combine. This happens when coal burns. Coal can contain up to 10 percent sulfur. Toxic heavy metals include mercury and lead. Mercury is used in some industrial processes. It is also found in fluorescent light bulbs. Lead was once widely used in gasoline, paint, and pipes. It is still found in some products. Volatile organic compounds (VOCs) are carbon compounds such as methane. VOCs are released in many human activities, such as raising livestock. Livestock wastes produce a lot of methane. Particulates are solid particles. These particles may be ash, dust, or even animal wastes. Many are released when fossil fuels burn (see Figure 22.1). Secondary pollutants form when primary pollutants undergo chemical reactions after they are released. Many occur as part of photochemical smog. This type of smog is seen as a brown haze in the air. Photochemical smog forms when certain pollutants react together in the presence of sunlight. You can see smog hanging in the air over San Francisco in Figure 22.2. Photochemical smog consists mainly of ozone (O3 ). The ozone in smog is the same compound as the ozone in the ozone layer,(O3 ). But ozone in smog is found near the ground. Figure 22.3 shows how it forms. When nitrogen oxides and VOCs are heated by the Sun, they lose oxygen atoms. The oxygen atoms combine with molecules of oxygen to form ozone. Smog ozone is harmful to humans and other living things. Most pollutants enter the air when fossil fuels burn. Some are released when forests burn.", "neg": "Treat with Respect The speed with which Man is changing the face of Earth has outstripped all the mighty processes of nature put together. In his haste to supply himself with increasing quantities of Earth's treasures he risks destroying one he greatly needs, his natural surroundings. Some countries set aside unspoiled areas of natural beauty. prefix = st1 /Canadahas the largest system of national parks in the world, 29 in all covering about 13 million hectares, preserving the different landscapes and the plant and animal life. Other countries are restoring areas which have been reduced to waste land by mining. At Broken Hill in Australiadrifting sand from rock crushing turned the area into a desert swept by sand storms. This is now being irrigated, fertilized and planted with grass and trees. In Great Britain quarries and gravel pits are being filled in or made into lakes, industrial wasteland is being turned into playing fields and waste tips into sloping green hills. However Man tries to look after Earth, the fact is that he is using up at a great rate resources, especially fuel resources, which have taken millions of years to accumulate and which he cannot renew. Yet every day the Earth receives a huge supply of energy from the Sun. Man has made several experiments in using solar energy to heat furnaces , cookers, and water-distillers. In space technology, e.g. on satellites, solar cells convert sunlight into electricity. Houses and offices have been designed which are centrally heated by water or air heated by the sunlight. When Man can trap and store this energy, so that he can use it exactly as he needs it, he will have not only an endless supply, but a clean and safe one.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}293{"query": "\"People are ruder today because they are rushed and more 'time poor' than ever before, \" says Patsy Rowe, \" Manners have fallen off the radar . \" Due to our strong attraction to electronic equipment it is a wonder more people don't wake up each morning and greet the singing birds with a complaint about the noise. Here are some examples of rudeness. Some people prefer to do almost everything over the internet. To them, dealing with an actual human is like an evolutionary step backward. It feels very slow because humans don, t work at 4G speeds. When you have dinner with friends, you will often notice someone paying more attention to his mobile phone. We have programmed ourselves to think that every new message brings life-changing news, so taking calls and checking our texts are more important than talking to the people we are with. What is worse, some people even tend to send anonymous rude messages by email. However, rudeness is never acceptable, Don, t assume it is OK to be rude if the person you, re in touch with won, t recognize you. If you have something awful to say, have the courage to face the person and say it, write a letter or email and sign it, or forget it. Upsetting people with unsigned messages is cruel and disgusting. We shouldn't blame technology for our shortcomings. Technology is here to help us, but we should not allow it to take over our lives. An important step is acknowledging our shortcomings. People spend a lot of time pointing out bad manners but it would be even more help if we'd publicly acknowledge good manners when we see them.", "pos": "The days of the sneak thief who stole a couple of apples or a packet of sweets from a chain store are actually over. I had a chance to say this to a young offender the other day, \"Sweets from a chain store?\" He said, \"You must be joking. That's what kids do.\" I may add that he was aged 11. In other words, today's young criminals would find it laughable to risk being caught for petty theft of this description. They've got enough money in their pockets to buy the sweets they want, anyway. I think it's all too easy to put the blame on anyone but ourselves. Faced as they are with a society that frequently gives them up on the grounds of color1, race or low learning ability, these children turn to crime as a means of showing off their self-respect. Nurtured on films and TV glamorizing the role of the criminal, they are quick to copy these anti-heroes. It is a matter of increasing concern to the police and government that the Children and Young Persons Act, 1969, is becoming improper to deal with the rise in young criminals. Because the emphasis has been placed on the cause and gentle treatment of their crimes, rather than on old-fashioned methods of punishment, the children themselves know well that there is very little that can be done to prevent them continuing to steal, damage and in some case even cause the death of those they choose to terrorize . I don't like the look of this situation any more than you do. In our own interests and in those of our children and grandchildren, we cannot continue to take the \"it's nothing to do with me\" attitude we have used for so long. We must unite in a common demand for harder and stricter methods against these young criminals.", "neg": "When my mother was alive, she used to tell me again and again about the value of just being nice. \"Never underestimate the power of a smile,\" she would say. I fear she would be very disappointed looking at the world today. A lot of people don't smile and when it comes to service today, they're just not nice. Now don't give me wrong, not all service workers but a good many. I was on the phone the other day with a computer help desk. First a man, then later a woman, who couldn't have been ruder. And this to a customer, who didn't know his way around a PC. But no matter, I could tell they thought I was a bother, The woman, in fact, seemed to be chewing gum as she unemotionally clicked off a series of commands for me to perform. The next day I heard from a friend of mine who got a performance review without his boss once looking up at him. Not once. You see it everywhere. Gone are the days when people cared about you. It's a sign of the time, I suspect. But that makes me sad -- for them and for us all. People who aren't happy, who don't smile, who don't kid, who don't joke or make light of even bad situations, make for an even worse situation. And it spreads like a cancer. Someone's rude to you, you're rude to them and to the next fellow you meet, and on and on. Smiles are contagious but so annoyances. The boss who can't be bothered with his workers. The celebrity who can't be bothered with her annoying fans. You know, my mom used to judge presidential candidates by how they smiled. I would say, \"But mom, you don't know if that smile is real.\" \"Oh, yes I do,\" she would tell me. \"I can feel it.\" It's in their eyes, she would say. And it's in their smile. The rest just kind of falls into place.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}294{"query": "The Old Toronto Star Building was an Art Deco office tower in Toronto, Ontario, Canada.", "pos": "Edificio La Nacional is an Art Deco office building located in Avenida Juarez, in the Historical Centre of Mexico City, just across the street from Palacio de Bellas Artes.The building's architect was Manuel Ortiz Monasterio.", "neg": "Artangel is a London-based arts organisation founded in 1985 by Roger Took.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}295{"query": "Woody lives in a slum on the edge of the city, and is exasperated at his bills. He wishes aloud that he were rich. At that moment, a four-leaf clover appears in the floorboards. Woody takes it, hoping it will bring him good luck. To his surprise, it transforms into a leprechaun woodpecker. Speaking with an Irish brogue, it names itself as O'Toole, and demonstrates its seemingly endless magical abilities to Woody. It then grants him three wishes. An excited Woody immediately wishes for immense wealth.The leprechaun takes Woody to \"the end of the rainbow\", where Woody indeed finds himself swimming in money. He takes a bag of cash and runs out. At that moment, an alarm goes off. He turns around, and realizes he has just robbed from the First National Bank. He is immediately confronted by a police officer with an Irish brogue. While Woody attempts to deflect the blame onto the leprechaun, the police officer does not believe him. At that moment, the leprechaun woodpecker jumps in and saves Woody by bashing the officer over the head with a club.A lengthy chase ensues between the officer and Woody. The leprechaun continually helps Woody to escape from tight situations, until Woody is finally caught and handcuffed to two other officers. The leprechaun appears, and Woody tells it his second wish-- to be transported home safely. The leprechaun frees Woody, and replaces him with a skunk. The horrified officers run off down the street, trying to break away from the handcuffs without luck.Once Woody is back home, the leprechaun reminds him that \"a wish is not what pays the rent\", and goes to leave. However, Woody reminds the leprechaun that he still has one wish left, and angrily screams at it, \"GO TO BLAZES!\" The leprechaun, having no choice, jumps and plummets through the floor into Hell, where he came from. The Devil, also a woodpecker with an Irish brogue, laughs and welcomes the leprechaun back. Iris out.", "pos": "The film opens with an animated prologue revealing the origins of leprechauns, stating that they were summoned by a king to protect his gold from those who would try to steal it. After the death of the king the Leprechauns returned to their places of origin, all except one (Warwick Davis) who remained in the mortal world and through the ages slowly became corrupted and obsessed with the treasure he still guarded. In the present Father Jacob (Willie C. Carpenter) is chased through the construction site of the youth center he had planned on building by the Leprechaun, whose gold Jacob had taken to fund the building project. Using four-leaf clover laced holy water Jacob manages to banish the Leprechaun, summoning demonic hands which drag him underground, but soon after drops dead of injuries inflicted by the Leprechaun during the fight.One year later two down on their luck friends Emily Woodrow (Tangi Miller) and Lisa Duncan (Sherrie Jackson) have their fortune told when the clairvoyant Esmeralda (Donzaleigh Abernathy) who warns them that they will attain great wealth soon, but it must be denied as it will come at a great price and summon a terrible evil. While having a barbecue at the abandoned youth center construction site with Lisa, their stoner friend Jamie Davis (Page Kennedy) and her ex-boyfriend turned drug dealer Rory Jackson (Laz Alonso) Emily falls through a hole and discovers the Leprechaun's gold in an old tunnel where it was hidden by Father Jacob. Splitting up the gold (which is produced in a never ending amount by the chest it was contained in) evenly the quartet of friends use it to fulfill their fantasies, unaware that by taking the gold they have released the Leprechaun, who begins stalking the group (killing a guest who takes one of his coins at a party held by Jamie, prompting the police to temporarily arrest him). At the salon where Emily works the Leprechaun sneaks in and, after killing a regular customer, Doria, on the massage table by breaking her neck, attacks Emily, who barely escapes and warns Rory and the recently released Jamie, who rush to get to Lisa's. In her house Lisa is attacked by the Leprechaun and manages to fight him off for a short while, but is killed when the Leprechaun claws her in the stomach, with her friends finding her body moments later.While Emily and Jamie want to return the gold Rory does not and takes off with it; shortly after realizing Rory is gone Emily is attacked and chased outside by the Leprechaun, but is saved when Rory has a change of heart and comes back for her. Searching for Rory the Leprechaun stops by his house and kills Rory's profligate girlfriend Chanel (Keesha Sharp) by tearing out her upper jaw, reclaiming the gold she used to make a tooth while Rory and Emily are stopped and harassed by Officers Thompson (Beau Billingslea) and Whitaker (Chris Murray). After the Leprechaun appears and kills the two officers Emily and Rory escape and regroup with Jamie, only to be confronted by a machine gun wielding group of Rory's drug dealing rivals, led by Watson (Shiek Mahmud-Bey) and Cedric (Sticky Fingaz). Planning on executing Rory for infringing on their territory Watson and his gang are all disposed of by the Leprechaun, (who kills Watson and Cedric while the other two members run off) while Emily, Rory and Jamie drive off in Watson's car (which the Leprechaun latches to the bottom of for a short while) and go looking for help from Esmeralda.Advised to use four-leaf clovers against the Leprechaun by Esmeralda, Rory laces the hollow-point bullets of his gun with clovers Jamie finds in the marijuana Rory had earlier sold him. When the Leprechaun arrives Rory shoots him several times with the clover bullets, only for his gun to jam before he can finish the Leprechaun off. Rory and Emily are given the chance to run with the gold when the Leprechaun is distracted by Jamie and Esmeralda (the latter dying in a magical duel with the Leprechaun). Followed to the roof of the building Rory tries fighting the Leprechaun and is knocked out, though before the Leprechaun can kill him", "neg": "Brink (Sir Cedric Hardwicke) has recently taken Pud's (Bobs Watson) parents in an auto wreck. Brink later comes for Gramps (Lionel Barrymore). Believing Brink to be an ordinary stranger, the crotchety old Gramps orders Mr. Brink off the property. Pud comes out of the house and asks who the stranger was. Gramps is surprised and relieved that someone else could see the stranger; he was not merely a dream or apparition. Pud tells Gramps that when he does a good deed, he will be able to make a wish. Because his apples are constantly being stolen, Gramps wishes that anyone who climbs up his apple tree will have to stay there until he permits them to climb down. Pud inadvertently tests the wish when he has trouble coming down from the tree himself, becoming free only when Gramps says he can. Pud's busybody Aunt Demetria (Eily Malyon) has designs on Pud and the money left him by his parents. Gramps spends much time fending off her efforts to adopt the boy. Brink takes Granny Nellie (Beulah Bondi) in a peaceful death just after she finishes a bit of knitting. When Mr. Brink returns again for Gramps, the old man finally realizes who his visitor is. Determined not to leave Pud to Demetria, Gramps tricks Mr. Brink into climbing the apple tree. While stuck in the tree, he cannot take Gramps or anyone else. The only way anyone or anything can die is if they touch Mr. Brink or the apple tree. Demetria plots to have Gramps committed to a psychiatric hospital when he claims that Death is trapped in his apple tree. Gramps proves his story first by proving that his doctor, Dr. Evans (Henry Travers), can not even kill a fly they have captured. He offers further proof of his power by shooting Mr. Grimes (Nat Pendleton), the orderly who has come to take him to the asylum; Grimes lives when he should have died. Dr. Evans is now a believer, but he tries to convince Gramps to let Death down so people who are suffering can find release. Gramps refuses, so the doctor arranges for the local sheriff to commit Gramps while Pud is delivered to Demetria's custody. With the help of his housekeeper (Una Merkel), Gramps tricks both of them into believing they are scheduled to go with Mr. Brink when he comes down from the tree. They beg Gramps to convince Brink otherwise, and Demetria vows never to bother Gramps or Pud again. Gramps realizes that sooner or later he will have to let Brinks downDeath is an ultimately unavoidable part of life. He tries to say goodbye to Pud, who reacts angrily and tries to run away. Mr. Brink sees Pud in the yard and dares him to climb the tree. Pud gets over the fence Gramps has had built around the tree, but falls and is crippled for life. Distraught, Gramps lets Death down from the tree. He takes both Gramps and Pud, who find they can walk again. In the final scene, they walk together up a beautiful country lane and hear Granny Nellie calling to them from beyond a brilliant light.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}296{"query": "German submarine U-346 was a Type VIIC U-boat of Nazi Germany's Kriegsmarine during World War II. She was laid down at the Nordseewerke in Emden as yard number 218 on 28 October 1942, launched on 13 April 1943 and commissioned on 7 June of the same year under the command of Oberleutnant zur See Arno Leisten.", "pos": "German submarine U-331 was a Type VIIC U-boat of Nazi Germany's Kriegsmarine during World War II. The submarine was laid down on 26 January 1940 at the Nordseewerke yard at Emden, launched on 20 December 1940, and commissioned on 31 March 1941 under the command of Oberleutnant zur See Hans-Diedrich Freiherr von Tiesenhausen.", "neg": "Rear Admiral James Edward Jouett (7 February 1826 -- 30 September 1902), known as ''Fighting Jim Jouett of the American Navy'', was an officer in the United States Navy during the Mexican-American War and the American Civil War.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}297{"query": "J.K. Rowling had reused her magic and brought Dumbledore back to life. A spokesperson for the author confirmed Rowling had sent a letter and a package to a Texas teenager who optimistically found strength in the words of a Harry Potter film after witnessing the murder of her family. Fifteen-yiear-old Cassidy Stay lost both parent s and four _ to a gunman in Texas last month. Cassidy was shot in the head and survived the gunshot wound only because she played dead. Authorities had called her survival a miracle. Cassidy had seen the unimaginable tragedy, but was still thinking about happiness. At the memorial( ) for her family, Cassidy gave a speech in front of the media saying she believed her family was \"in a much better place.\" Quoting the words of Dumbledore, the wise headmaster of Hogwarts, she said, \"Happiness can be found even in the darkest of times, if one only remembers to turn on the light.\" The same day Cassidy gave her speech, a Facebook page called \"We want J.K. Rowling to meet Cassidy Stay\" formed and quickly draw public attention. The creator of the page claimed to know a friend of Cassidy's who \"confirmed that J.K. Rowling did write Cassidy a personal letter under the name of 'Dumbledor'. She also sent a wand, an acceptance letter to Hogwarts with a school supply list, along with the 3rdbook with Rowling's autograph.\"", "pos": "British author JK Rowling was at the release of her latest Harry Potter book called \"Harry Potter and the Deathly Hallows\" at the Natural History Museum in London, Friday July 20, 2007. J.K. Rowling has been spotted at cafes in Scotland working on a detective novel, a British newspaper reported Saturday. The Sunday Times newspaper quoted Ian Rankin, a fellow author and neighbor of Rowling's, as saying the creator of the \"Harry Potter\" books is turning to crime fiction. \"My wife spotted her writing her Edinburgh criminal detective novel,\" the newspaper quoted Rankin as telling a reporter at an Edinburgh literary festival. \"It is great that she has not abandoned writing or Edinburgh cafes,\" said Rankin, who is known for his own police novels set in the historic Scottish city. Rowling famously wrote initial drafts of the Potter story in the Scottish city's cafes. Back then, she was a struggling single mother who wrote in cafes to save on the heating bill at home. Now she's Britain's richest woman - worth $1 billion, according to Forbes magazine - and her seven Potter books have sold more than 335 million copies worldwide. In an interview with The Associated Press last month, Rowling said she believed she was unlikely to repeat the success of the Potter series, but confirmed she had plans to work on new books. \"I'll do exactly what I did with Harry - I'll write what I really want to write,\" Rowling said.", "neg": "When reporter ANN MITCHELL is laid off by managing editor HENRY CONNELL because of streamlining, she begs to stay on since she's supporting her MOTHER and TWO SISTERS, but it's no use. Angry, she gathers up her belongings but then, as a parting shot, types up a fake letter from \"John Doe\" stating that he's so downtrodden by the unfairness of things that he intends jumping off the building on Christmas Eve.The paper prints the letter and it causes a sensation. Everyone relates to and wants to help John Doe. Connell, desperate to get hold of the original letter is shocked when Ann tells him there was no letter. Connell, angry, is ready to print a retraction but Ann suggests that they hire a \"fake John Doe\" to embody the pathos of the letter. She gets her job back along with a lucrative fee and contract.Several desperate MEN line up claming to have written the letter, so Ann and Connell must now pick the one. When handsome JOHN WILLOUGHBY walks in, Ann's clearly smitten. A likeable, quiet baseball player who's fallen on bad times, John's the one who will become \"John Doe.\" Although he seems too honest to lie, Ann believes he's desperate enough. They create a fake letter, put him up at a fancy hotel with bodyguards, making him sign an agreement. Also in tow (much to Connell's chagrin) is THE COLONEL, a confirmed vagabond, distrustful of society, who warns John that he's falling into a trap of privilege.Next come publicity photos, which are directed by Ann to get the correct \"angry protest\" look. With headlines proclaiming his anger at the unfairness of the world, John becomes an increasing media sensation, courtesy of hyperbolic headlines concocted by Connell. Meanwhile, the GOVERNOR suspects John Doe is a myth but mistakenly feels it was concocted by publisher B. D. NORTON to discredit him. Ann convinces Norton to play it for what it's worth. Norton offers her money to write radio speeches to sell Doe. He also wants her to work directly with him and not Connell.Ann goes to work, typing up a storm but nothing comes to mind. Ann's Mother suggests that she write something upbeat and simple, using the values of Ann's late father as an inspiration. By now, John has begun realizing that his baseball career might not get started again if the John Doe business is revealed as a phony.Nonetheless, John reads his first manufactured upbeat speech, written by Ann to a packed house. Ann coaches him to be sincere, suggesting that she's fallen in love with John Doe. The speech, broadcast on the radio, stirs the people with its \"love thy neighbor\"-style message. CROWDS love him but John can't get away fast enough. He and the Colonel resort to the boxcars and flee. B. D. Norton, thinking he was great, wants him located.When a DINER WAITER recognizes him, John's hope for a return to normalcy is squelched by sudden CROWDS, eager to meet him. Ann and Norton locate him. John isn't happy about it. When Norton offers him a lecture tour, he refuses it angrily. When the common PEOPLE who have a \"John Doe\" club talk to him, however, he softens when hearing how he's touched them. Now, John's torn. His itinerant pal, The Colonel, thinks he's been \"hooked\" and, disgusted, walks out on him.Norton arranges the lecture tour. John speaks in state after state, addressing the many national clubs in his name. Connell tells Norton, however, that he's curious why Norton is spending so much money on the tour. In the meantime, Ann, knowing that John now likes her, feels increasingly like the heel she feels she is. She feels even worse when John relates a tender dream that he had about her and talks to her about how he relates to the lonely, hungry people to whom he's been speaking.Norton gives Ann a fur coat and a gift. He then tells her that he wants John Doe to announce a", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}298{"query": "The Museum der Volker in the Austrian Schwaz in the county of Tyrol was founded in 1995 as a cultural association Haus der Volker by Gert Chesi and belongs to the well known Ethnology museums in Europe.", "pos": "The Alexandria Museum of Art (AMoA) of Alexandria, central Louisiana, USA opened its doors in 1977 in the historic Rapides Bank Building (circa 1898).", "neg": "The Bearded Slave (Italian: Schiavo barbuto) is a marble sculpture by Michelangelo datable to around 1525--1530 and kept in the Galleria dell'Accademia in Florence.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}299{"query": "If prefix = st1 /U.S.software companies don't pay more attention to quality, they could kiss their business good-bye. BothIndiaandBrazilare developing a world-class software industry. Their weapon is quality and one of their jobs is to attract the topU.S.quality specialists whose voices are not listened to in their country. Already, of the world's 12 software houses that have earned the highest rating in the world, seven are in India. That's largely because they have used new methods rejected by American software specialists. For example, for decades, quality specialists, W. Edwards Deming and J. M. Juran had urgedU.S.software companies to change their attitudes to quality. But their quality call mainly fell on deaf ears in the U.S -- but not in Japan. By the 1970s and 1980s,Japanwas grabbing market share with better, cheaper products. They used Deming's and Juran's ideas to bring down the cost of good quality to as little as 5% of total production costs. InU.S.factories, the cost of quality then was 10 times as high: 50%. In software, it still is. Watts S. Humphrey spent 27 years at IBM heading up software production and then quality assurance. But his advice was seldom paid attention to. He retired from IBM in 1986. In 1987, he worked out a system for assessing(evaluating) and improving software quality. It has proved its value time and again. For example, in 1990 the cost of quality at Raytheon Electronics Systems was almost 60% of total software production costs. It fell to 15% in 1996 and has since further dropped to below 10%. Like Deming and Juran, Humphrey seems to be winning more praises overseas than at home. The Indian government and several companies have just founded the Watts Humphrey Software Quality Institute at the Software Technology Park in Chennai,India. Let's hope thatU.S.lead in software will not be eaten up by its quality problems.", "pos": "Is it time to kick Russia out of the BRICs ? If so, it may end up sounding like a famous ball-point pen maker-BIC. An argument is being made that Goldman Sach's famous marketing device ,the BRICs, should really be the BICs. \"Is Russia really worth the name BRICs?\" asks Anders Aslund, senior fellow at the Peterson Institute for International Economics, in an article for Foreigh Policy. Aslund, who is also co-author with Andrew Kuchins of \"The Russian Balance Sheet\", thinks the Russia of Putin and Medvedev is just not worthy of inclusion alongside Brazil, India and China in the list of future economic powerhouses. He writes: \"The country's economic performance has fallen to such a weak level that one must ask whether it has any say at all on the global economy, compared with the other members of its group. I have just returned from Moscow, which is always dull around this season. For the last seven years, Russia has taken very few measures to improve its economy. Instead, the state has been living on oil and gas. \" Economically, Aslund has the numbers on his side. The International Monetary Fund figures that the Russian economy will fall by 6.7 percent in 2009, while China will grow 8.5 percent and India 5.4 percent. There is less of a case for Brazil, with a fall of 0.7 percent, but it is still doing far better than Russia. But the BRICs are not just about economy. As is mentioned above, it is a marketing device to encourage investors to focus on the big promising players. From an investment standpoint, it could be argued that Russia is leading the BRICs. Its stock market is up 128 percent this year while around 80 percent is for the other three. At very least, however, Russia's economic underperformance and stock market outperfoumance does suggest it is indeed one of the group.", "neg": "A pivotal phase III study of the RTS,S/AS01 malaria candidate vaccine is ongoing in several research centres across Africa. The development and establishment of quality systems was a requirement for trial conduct to meet international regulatory standards, as well as providing an important capacity strengthening opportunity for study centres. Standardized laboratory methods and quality assurance processes were implemented at each of the study centres, facilitated by funding partners. A robust protocol for determination of parasite density based on actual blood cell counts was set up in accordance with World Health Organization recommendations. Automated equipment including haematology and biochemistry analyzers were put in place with standard methods for bedside testing of glycaemia, base excess and lactacidaemia. Facilities for X-rays and basic microbiology testing were also provided or upgraded alongside health care infrastructure in some centres. External quality assurance assessment of all major laboratory methods was established and method qualification by each laboratory demonstrated. The resulting capacity strengthening has ensured laboratory evaluations are conducted locally to the high standards required in clinical trials. Major efforts by study centres, together with support from collaborating parties, have allowed standardized methods and robust quality assurance processes to be put in place for the phase III evaluation of the RTS, S/AS01 malaria candidate vaccine. Extensive training programmes, coupled with continuous commitment from research centre staff, have been the key elements behind the successful implementation of quality processes. It is expected these activities will culminate in healthcare benefits for the subjects and communities participating in these trials. Clinicaltrials.gov NCT00866619.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}300{"query": "897 Lysistrata is a minor planet orbiting the Sun that was discovered by German astronomer Max Wolf on August 3, 1918.", "pos": "720 Bohlinia is a minor planet orbiting the Sun that was discovered by Franz Kaiser, a German astronomer in 1911.", "neg": "A proton is one of three main particles that make up the atom. The other two particles are the neutron and electron. Protons are found in the nucleus of the atom. This is a tiny, dense region at the center of the atom. Protons have a positive electrical charge of one (+1) and a mass of 1 atomic mass unit (amu), which is about 1.67 1027 kilograms. Together with neutrons, they make up virtually all of the mass of an atom. Click image to the left or use the URL below. URL: Q: How do you think the sun is related to protons? A: The suns tremendous energy is the result of proton interactions. In the sun, as well as in other stars, protons from hydrogen atoms combine, or fuse, to form nuclei of helium atoms. This fusion reaction releases a huge amount of energy and takes place in nature only at the extremely high temperatures of stars such as the sun. All protons are identical. For example, hydrogen protons are exactly the same as protons of helium and all other elements, or pure substances. However, atoms of different elements have different numbers of protons. In fact, atoms of any given element have a unique number of protons that is different from the numbers of protons of all other elements. For example, a hydrogen atom has just one proton, whereas a helium atom has two protons. The number of protons in an atom determines the electrical charge of the nucleus. The nucleus also contains neutrons, but they are neutral in charge. The one proton in a hydrogen nucleus, for example, gives it a charge of +1, and the two protons in a helium nucleus give it a charge of +2. Protons are made of fundamental particles called quarks and gluons. As you can see in the Figure 1.1, a proton contains three quarks (colored circles) and three streams of gluons (wavy white lines). Two of the quarks are called up quarks (u), and the third quark is called a down quark (d). The gluons carry the strong nuclear force between quarks, binding them together. This force is needed to overcome the electric force of repulsion between positive protons. Although protons were discovered almost 100 years ago, the quarks and gluons inside them were discovered much more recently. Scientists are still learning more about these fundamental particles.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}301{"query": "Noisia, stylized as NOISI ('VISION' rotated 180), is a Dutch electronic music trio consisting of members Nik Roos, Martijn van Sonderen and Thijs de Vlieger from Groningen, Netherlands.", "pos": "The Glitch Mob is an American three-piece electronic music group from Los Angeles, California.", "neg": "The Three Little Wolves and the Big Bad Pig is a children's picture book written by Eugene Trivizas (Evgenios Trivizas), illustrated by Helen Oxenbury, and first published by Heinemann in 1993.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}302{"query": "Flatworms are invertebrates that belong to Phylum Platyhelminthes. There are more than 25,000 species in the flatworm phylum. Not all flatworms are as long as tapeworms. Some are only about a millimeter in length. Flatworms have a flat body because they lack a fluid-filled body cavity. They also have an incomplete digestive system with a single opening. However, flatworms represent several evolutionary advances in invertebrates. They have the following adaptations: Flatworms have three embryonic cell layers. They have a mesoderm layer in addition to ectoderm and endoderm layers. The mesoderm layer allows flatworms to develop muscle tissues so they can move easily over solid surfaces. Flatworms have a concentration of nerve tissue in the head end. This was a major step in the evolution of a brain. It was also needed for bilateral symmetry. Flatworms have bilateral symmetry. This gives them a better sense of direction than radial symmetry would. Watch this amazing flatworm video to learn about some of the other firsts these simple animals achieved, including being the first hunters: [Link] MEDIA Click image to the left or use the URL below. URL: Flatworms reproduce sexually. In most species, the same individuals produce both eggs and sperm. After fertilization occurs, the fertilized eggs pass out of the adults body and hatch into larvae. There may be several different larval stages. The final larval stage develops into the adult form. Then the life cycle repeats. Some flatworms live in water or moist soil. They eat invertebrates and decaying animals. Other flatworms, such as tapeworms, are parasites that live inside vertebrate hosts. Usually, more than one type of host is needed to complete the parasites life cycle, as shown in Figure 12.12. Roundworms are invertebrates in Phylum Nematoda. This is a very diverse phylum. It has more than 80,000 known species. Roundworms range in length from less than 1 millimeter to over 7 meters in length. You can see an example of a roundworm in Figure 12.13. Roundworms have a round body because they have a partial fluid-filled body cavity (pseudocoelom). This is one way that roundworms differ from flatworms. Another way is their complete digestive system. It allows them to eat, digest food, and eliminate wastes all at the same time. Roundworms have a tough covering of cuticle on the surface of their body. It prevents their body from expanding. This allows the buildup of fluid pressure in their partial body cavity. The fluid pressure adds stiffness to the body. This provides a counterforce for the contraction of muscles, allowing roundworms to move easily over surfaces. Roundworms reproduce sexually. Sperm and eggs are produced by separate male and female adults. Fertilization takes place inside the female organism. Females lay huge numbers of eggs, sometimes as many as 100,000 per day! The eggs hatch into larvae, which develop into adults. Then the life cycle repeats. Roundworms may be free-living or parasitic organisms. Free-living worms are found mainly in freshwater habitats. Some live in moist soil. They generally feed on bacteria, fungi, protozoa, or decaying organic matter. By breaking down organic matter, they play an important role in the carbon cycle. Parasitic roundworms may have plant, invertebrate, or vertebrate hosts. Several roundworm species infect humans. Besides ascaris, they include hookworms. Hookworms are named for the hooks they use to grab onto the hosts intestines. You can see the hooks in Figure 12.14. Hookworm larvae enter the host through the skin. They migrate to the intestine, where they mature into adults. Female adults lay large quantities of eggs. Eggs pass out of the host in feces. Eggs hatch into larvae in the feces or soil. Then the cycle repeats. You can learn more about parasitic roundworms in humans by watching this short video: . MEDIA Click image to the left or use the URL below. URL:", "pos": "Have you ever been to the ocean or eaten seafood? If you have, then youve probably encountered members of Phylum Mollusca. In addition to snails, mollusks include squids, slugs, scallops, and clams. You can see a clam in Figure 12.15. There are more than 100,000 known species of mollusks. Some mollusks are nearly microscopic. The largest mollusk, the colossal squid, may be as long as a school bus and weigh over half a ton! Watch this short video to see an amazing diversity of mollusks: . MEDIA Click image to the left or use the URL below. URL: Mollusks have a true coelom and complete digestive system. They also have circulatory and excretory systems. They have a heart that pumps blood, and organs that filter out wastes from the blood. You can see some other traits of mollusks in the garden snail in Figure 12.16. Like the snail, many other mollusks have a hard outer shell. It is secreted by special tissue called mantle on the outer surface of the body. The shell covers the top of the body and encloses the internal organs. Most mollusks have a distinct head region. The head may have tentacles for sensing the environment and grasping food. Mollusks generally have a muscular foot, which may be used for walking or other purposes. A unique feature of mollusks is the radula. This is a feeding organ with teeth made of chitin. It is located in front of the mouth in the head region. It can be used to scrape algae off rocks or drill holes in the shells of prey. You can see the radula of the sea slug in Figure 12.17. Mollusks reproduce sexually. Most species have separate male and female sexes. Fertilization may be internal or external, depending on the species. Fertilized eggs develop into larvae. There may be one or more larval stages. Each one is different from the adult stage. Mollusks live in most terrestrial, freshwater, and marine habitats. However, the majority of species live in the ocean. They can be found in both shallow and deep water and from tropical to polar latitudes. They have a variety of ways of getting food. Some are free-living heterotrophs. Others are internal parasites. Mollusks are also eaten by many other organisms, including humans. Annelids are segmented worms in Phylum Annelida. There are about 15,000 species of annelids. They range in length from less than a millimeter to more than 3 meters. To learn more about the amazing diversity and adaptations of annelids, watch this excellent video: [Link] MEDIA Click image to the left or use the URL below. URL: Annelids are divided into many repeating segments. The earthworm in Figure 12.18 is an annelid. You can clearly see its many segments. Segmentation of annelids is highly adaptive. Each segment has its own nerve and muscle tissues. This allows the animal to move very efficiently. Some segments can also be specialized to carry out particular functions. They may have special structures on them. For example, they might have tentacles for sensing or feeding, paddles for swimming, or suckers for clinging to surfaces. Annelids have a large coelom. They also have several organ systems. These include a: circulatory system; excretory system; complete digestive system; and nervous system, with a brain and sensory organs. Most annelids can reproduce both asexually and sexually. Asexual reproduction may occur by budding or fission. Sexual reproduction varies by species. Some species go through a larval stage before developing into adults. Other species grow to adult size without going through a larval stage. Annelids live in a diversity of freshwater, salt-water, and terrestrial habitats. They vary in what they eat and how they get their food. Some annelids, such as earthworms, eat soil and extract organic material from it. Annelids called leeches are either predators or parasites. Some leeches capture and eat other invertebrates. Others feed off the blood of vertebrate hosts. Annelids called polychaete worms live on the ocean floor. They may be filter feeders, predators, or scavengers. The amazing feather duster worm in Figure 12.19 is a polychaete that has a fan-like crown of", "neg": "_ (from How Do Animals Move?) Many animals scurry up tree trunks to escape enemies or find food. Some live in the treetops. Many of these animals are not only expert climbers, but they also have found interesting ways to get from tree to tree. How Do Animals Adapt?andHow Do Animals Move? are comprehensive explorations of animal adaptations and movement for young readers. Both are part of a 21 book series,The Science of Living Things. InHow Do Animals Adapt?readers learn how animals adapt to survive with respect not only to climate, darkness, food and defenses but also to offspring and people. These adaptations are well explained in double page spreads with examples clearly depicted in photographs and diagrams and developed through their accompanying captions . As the title suggests, movement is the focus ofHow Do Animals Move?Beginning with a description of the explanation of movement, the reader is exposed to the many different ways of animals movement in the air, on land, under ground and in the water. Several unconventional variations (e.g. looping of inchworms, the rectilinear motion of snakes) are included. Once again, the photographs and diagrams plainly support the double page spread discussions of animal movement. The language of both titles is simple enough for young readers without talking down to them. In both books, terminology is featured in . Some of these words are explained in the basic glossary while the majority are explained clearly in the text. Many of these terms provide readers with some fascinating, uncommon words (e.g. brachiation, potassium, skein, and estimate). As do many of Kalman's book, both of these titles have a table of contents, glossary and index which are all enough to introduce young readers to the nature of these tools. Both titles would make excellent additions to any science collection for young readers.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}303{"query": "Work is the use of force to move an object. It is directly related to both the force applied to the object and the distance the object moves. Work can be calculated with this equation: Work = Force x Distance. The equation for work can be used to calculate work if force and distance are known. To use the equation, force is expressed in Newtons (N), and distance is expressed in meters (m). For example, assume that Clarissa uses 100 Newtons of force to push the mower and that she pushes it for a total of 200 meters as she cuts the grass in her grandmothers yard. Then, the amount of work Clarissa does is: Work = 100 N 200 m = 20,000 N m Notice that the unit for work in the answer is the Newton meter (N m). This is the SI unit for work, also called the joule (J). One joule equals the amount of work that is done when 1 N of force moves an object over a distance of 1 m. Q: After Clarissa mows her grandmothers lawn, she volunteers to mow a neighbors lawn as well. If she pushes the mower with the same force as before and moves it over a total of 234 meters, how much work does she do mowing the neighbors lawn? A: The work Clarissa does can be calculated as: Work = 100 N 234 m = 23,400 N m, or 23,400 J The work equation given above can be rearranged to find force or distance if the other variables are known: Force = Work Distance Distance = Work Force After Clarissa finishes mowing both lawns, she pushes the lawn mower down the sidewalk to her own house. If she pushes the mower over a distance of 30 meters and does 2700 joules of work, how much force does she use? Substitute the known values into the equation for force: J Force = 2700 30 m = 90 N Q: When Clarissa gets back to her house, she hangs the 200-Newton lawn mower on some hooks in the garage (see the Figure 1.1). To lift the mower, she does 400 joules of work. How far does she lift the mower to hang it? A: Substitute the known values into the equation for distance:", "pos": "Work is defined differently in physics than in everyday language. In physics, work means the use of force to move an object. The teens who are playing basketball in the picture above are using force to move their bodies and the basketball, so they are doing work. The teen who is studying isnt moving anything, so she isnt doing work. Not all force that is used to move an object does work. For work to be done, the force must be applied in the same direction that the object moves. If a force is applied in a different direction than the object moves, no work is done. The Figure 1.1 illustrates this point. Q: If the box the man is carrying is very heavy, does he do any work as he walks across the room with it? A: Regardless of the weight of the box, the man does no work on it as he holds it while walking across the room. However, he does more work when he first lifts a heavier box to chest height. Work is directly related to both the force applied to an object and the distance the object moves. It can be represented by the equation: Work = Force Distance This equation shows that the greater the force that is used to move an object or the farther the object is moved, the more work that is done. To see the effects of force and distance on work, compare the weight lifters in the Figure 1.2. The two weight lifters on the left are lifting the same amount of weight, but the one on the bottom is lifting the weight a greater distance. Therefore, this weight lifter is doing more work. The two weight lifters on the bottom right are both lifting the weight the same distance, but the weight lifter on the left is lifting a heavier weight, so she is doing more work.", "neg": "Do you have imagination? Do you like to solve problems? Can you? If so, you could be the next great inventor. \"But I'm just a kid\",you might be! Don't worry about a little thing like age. For example, one famous inventor-- Benjamin Franklin--got his start when he was only 12. At that young age, he created paddles for his hands to help him swim faster. Finally his creation led to what we know is called flippers! So you don't have to be adult to be an inventor. One thing you do need, though, is something that kids have plenty of: curiosity and imagination. Kids are known for looking at things in new and unique ways. So what should you do if you have what is a great idea for an invention? Talk to a friend or family member about it. Get input from others about your idea. Then ask them to help you create a working model--called a prototype of your idea. Once you have a prototype, you can test it. Sometimes your idea turns out to be not as great as you thought. At other times, though, you realize it is a good idea and your prototype can help you figure out how to make it even better. If your idea is really a good one, an adult can help you contact companies that might be interested in it. You will also want an adult's help to get a patent for your idea, so that it is protected and can't be stolen by someone else. If you need some inspiration, consider these kids and their inventions: Jeanie Low invented the Kiddie Stool when she was just 11. It's a folding stool that fits under the kitchen sink. Kids can unfold it and use it to reach the sink all by themselves. At the age of 15, Louis Braille invented the system named after him that allows the blind to read. Chelsea Lanmon received a patent when she was just 8 for the \"pocket diaper \",a new type of diaper that includes a pocket for holding baby wipes and powder.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}304{"query": "Tom Denney (born November 23, 1982) is an American musician from Ocala, Florida.", "pos": "Maxime Bono (born 1 November 1947 in Algiers, Algeria) is a French politician and a member of the Socialist party.", "neg": "Vegard Skjerve (born 22 May 1988) is a Norwegian footballer who plays as a defender for Haugesund.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}305{"query": "Bhavan's Lloyds Vidya Niketan (or BLVN) is a private secondary school in Bhugaon, Wardha, India, established in 1995.", "pos": "Newbury Academy was an alternative private high school serving students in grades 9-12 that opened in September 2001, based in Dumont, New Jersey.", "neg": "Christian Chalmin, publisher, born in 1947 at Autry-Issards and Mayor of the commune from 1989 to 1995.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}306{"query": "Although soil scientists recognize thousands of types of soil - each with its own specific characteristics and name - lets consider just three soil types. This will help you to understand some of the basic ideas about how climate produces a certain type of soil, but there are many exceptions to what we will learn right now (Figure 1.1). Just some of the thousands of soil types. Deciduous trees, the trees that lose their leaves each winter, need at least 65 cm of rain per year. These forests produce soils called pedalfers, which are common in many areas of the temperate, eastern part of the United States (Figure 1.2). The word pedalfer comes from some of the elements that are commonly found in the soil. The \"Al\" in pedalfer is the chemical symbol of the element aluminum, and the \"Fe\" in pedalfer is the chemical symbol for iron. Pedalfers are usually a very fertile, dark brown or black soil. Not surprisingly, they are rich in aluminum clays and iron oxides. Because a great deal of rainfall is common in this climate, most of the soluble minerals dissolve and are carried away, leaving the less soluble clays and iron oxides behind. A pedalfer is the dark, fertile type of soil that will form in a forested region. Pedocal soils form in drier, temperate areas where grasslands and brush are the usual types of vegetation (Figure chemical weathering and less water to dissolve away soluble minerals, so more soluble minerals are present and fewer clay minerals are produced. It is a drier region with less vegetation, so the soils have lower amounts of organic material and are less fertile. A pedocal is named for the calcite enriched layer that forms. Water begins to move down through the soil layers, but before it gets very far, it begins to evaporate. Soluble minerals, like calcium carbonate, concentrate in a layer that marks the lowest place that water was able to reach. This layer is called caliche. A lizard on soil typical of an arid region in Mexico. In tropical rainforests where it rains literally every day, laterite soils form (Figure 1.4). In these hot, wet, tropical regions, intense chemical weathering strips the soils of their nutrients. There is practically no humus. All soluble minerals are removed from the soil and all plant nutrients are carried away. All that is left behind are the least soluble materials, like aluminum and iron oxides. These soils are often red in color from the iron oxides. Laterite soils bake as hard as a brick if they are exposed to the Sun. A laterite is the type of thick, nutrient-poor soil that forms in the rainforest. Many climate types have not been mentioned here. Each produces a distinctive soil type that forms in the particular circumstances found there. Where there is less weathering, soils are thinner but soluble minerals may be present. Where there is intense weathering, soils may be thick but nutrient-poor. Soil development takes a very long time, it may take hundreds or even thousands of years for a good fertile topsoil to form. Soil scientists estimate that in the very best soil-forming conditions, soil forms at a rate of about 1mm/year. In poor conditions, soil formation may take thousands of years!", "pos": "How well soil forms and what type of soil forms depends on several different factors, which are described below. Scientists know that climate is the most important factor determining soil type because, given enough time, different rock types in a given climate will produce a similar soil (Figure 1.1). Even the same rock type in different climates will not produce the same type of soil. This is true because most rocks on Earth are made of the same eight elements and when the rock breaks down to become soil, those elements dominate. The same factors that lead to increased weathering also lead to greater soil formation. More rain equals more chemical reactions to weather minerals and rocks. Those reactions are most efficient in the top layers of the soil, where the water is fresh and has not yet reacted with other materials. Increased rainfall increases the amount of rock that is dissolved as well as the amount of material that is carried away by moving water. As materials are carried away, new surfaces are exposed, which also increases the rate of weathering. Climate is the most important factor in determining the type of soil that will form in a particular area. Increased temperature increases the rate of chemical reactions, which also increases soil formation. In warmer regions, plants and bacteria grow faster, which helps to weather material and produce soils. In tropical regions, where temperature and precipitation are consistently high, thick soils form. Arid regions have thin soils. Soil type also influences the type of vegetation that can grow in the region. We can identify climate types by the types of plants that grow there. The original rock is the source of the inorganic portion of the soil. The minerals that are present in the rock determine the composition of the material that is available to make soil. Soils may form in place or from material that has been moved. Residual soils form in place. The underlying rock breaks down to form the layers of soil that reside above it. Only about one-third of the soils in the United States are residual. Transported soils have been transported in from somewhere else. Sediments can be transported into an area by glaciers, wind, water, or gravity. Soils form from the loose particles that have been transported to a new location and deposited. The steeper the slope, the less likely material will be able to stay in place to form soil. Material on a steep slope is likely to go downhill. Materials will accumulate and soil will form where land areas are flat or gently undulating. Soils thicken as the amount of time available for weathering increases. The longer the amount of time that soil remains in a particular area, the greater the degree of alteration. The partial decay of plant material and animal remains produces the organic material and nutrients in soil. In soil, decomposing organisms breakdown the complex organic molecules of plant matter and animal remains to form simpler inorganic molecules that are soluble in water. Decomposing organisms also create organic acids that increase the rate of weathering and soil formation. Bacteria in the soil change atmospheric nitrogen into nitrates. The decayed remains of plant and animal life are called humus, which is an extremely important part of the soil. Humus coats the mineral grains. It binds them together into clumps that then hold the soil together, creating its structure. Humus increases the soils porosity and water-holding capacity and helps to buffer rapid changes in soil acidity. Humus also helps the soil to hold its nutrients, increasing its fertility. Fertile soils are rich in nitrogen, contain a high percentage of organic materials, and are usually black or dark brown in color. Soils that are nitrogen poor and low in organic material might be gray or yellow or even red in color. Fertile soils are more easily cultivated. Click image to the left or use the URL below. URL:", "neg": "The major cause of outdoor air pollution is the burning of fossil fuels. Fossil fuels are burned in power plants, factories, motor vehicles, and home heating systems. Ranching and using chemicals such as fertilizers also cause outdoor air pollution. Erosion of soil in farm fields, mining activities, and construction sites adds dust particles to the air as well. Some specific outdoor air pollutants are described in Table 25.1. Air Pollutant Sulfur oxides Nitrogen oxides Carbon monoxide Carbon dioxide Particles (dust, smoke) Mercury Smog Ground-level ozone Source coal burning motor vehicle exhaust motor vehicle exhaust all fossil fuel burning wood and coal burning coal burning coal burning motor vehicle exhaust Problem acid rain acid rain poisoning global climate change respiratory problems nerve poisoning respiratory problems respiratory problems Outdoor air pollution causes serious human health problems. For example, pollutants in the air are major contributors to respiratory and cardiovascular diseases. Air pollution may trigger asthma attacks and heart attacks in people with underlying health problems. In fact, more people die each year from air pollution than automobile accidents. Air pollution may also cause acid rain. This is rain that is more acidic (has a lower pH) than normal rain. Acids form in the atmosphere when nitrogen and sulfur oxides mix with water in air. Nitrogen and sulfur oxides come mainly from motor vehicle exhaust and coal burning. If acid rain falls into lakes, it lowers the pH of the water and may kill aquatic organisms. If it falls on the ground, it may damage soil and soil organisms. If it falls on plants, it may make them sick or even kill them. Acid rain also damages stone buildings, bridges, and statues, like the one in Figure 25.1. Another major problem caused by air pollution is global climate change. Gases such as carbon dioxide from the burning of fossil fuels increase the greenhouse effect and raise Earths temperature. The greenhouse effect is a natural feature of Earths atmosphere. It occurs when certain gases in the atmosphere, including carbon dioxide, radiate the suns heat back down to Earths surface. Figure 25.2 shows how this happens. Without greenhouse gases in the atmosphere, the heat would escape into space. The natural greenhouse effect of Earths atmosphere keeps the planets temperature within a range that can support life. The rise in greenhouse gases due to human actions is too much of a good thing. It increases the greenhouse effect and causes Earths average temperature to rise. Rising global temperatures, in turn, are melting polar ice caps and glaciers. Figure 25.3 shows how much smaller the Arctic ice cap was in 2012 than it was in 1984. With more liquid water on Earths surface, sea levels are rising. Adding more heat energy to Earths atmosphere also causes more extreme weather and changes in precipitation patterns. Global warming is already causing food and water shortages and species extinctions. These problems will only grow worse unless steps are taken to curb greenhouse gases and global climate change. You may be able to avoid some of the health effects of outdoor air pollution by staying indoors on high-pollution days. However, some indoor air is just as polluted as outdoor air. One source of indoor air pollution is radon gas. Radon is a radioactive gas that may seep into buildings from rocks underground. Exposure to radon gas may cause lung cancer. Another potential poison in indoor air is carbon monoxide. It may be released by faulty or poorly vented furnaces or other fuel-burning appliances. Indoor furniture, carpets, and paints may release toxic compounds into the air as well. Other possible sources of indoor air pollution include dust, mold, and pet dander. Its easier to control the quality of indoor air than outdoor air. Steps home owners can take to improve indoor air quality include: keeping the home clean so it is as free as possible from dust, mold, and pet dander. choosing indoor furniture, flooring, and paints that are low in toxic compounds such as VOCs (volatile organic compounds). making sure that fuel-burning appliances are working correctly and venting properly. installing carbon monoxide alarms like the one in Figure 25.4 at every level of the home.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}307{"query": "English Language and Culture Program If you wish to improve your English-language skills as well as your understanding of the Canadian cultural context, the courses offered by ELC Evening are for you. Whether your goals are academic, business or immigration-related, there is a course to meet your needs. Evening course tuition:$490,0. All evening courses run for 10 weeks.A $50 discount is available to returning students or students attending two or more courses. ELC 550 Mondays, July 7 - September 22, 2008August 4 & September 11- HOLIDAY Mondays, October 6-December 15.2008 October 13-HOLIDAY This course is designed for non-native Englisli speakers who wish to take the 1ELTS (International English Language Testing System) exam.Each week, participants focus on specific modules of the test (speaking, reading, listening, and writing) to develop and improve the skills they need to succeed on the exam. ELC 552 Tuesdays, Aprils8-June 10,2008 Tuesdays, October 7 - December.16, 2008 November 11 - HOLIDAY This course is designed for participants who wish to improve their fluency and expressiveness in English.Production skills will be targeted, including pronunciation, intonation, rhythm, and stress.Participants are required to complete weekly in-class assignments , including speeches, monologues, interviews, and role-plays. ELC 554 Wednesdays, July 9 - September 10.2008 Wednesdays, October 8 -December 10.2008 This course is designed for non-native English-speaking university and college participants who wish to improve their academic leading and writing skills.This course gives participants the tools required for presenting information and building persuasive arguments in clear and cohesive written forms. ELC 555 Thursdays, July 10 - September 11, 2008 Thursdays, October 9 - December 11, 2008 This course is designed for non-native English speakers who are either working or planning to work in a business environment.Areas of focus include handling telephone conversations, networking, participating in meetings, negotiating, making presentations, and conducting interviews.", "pos": "Used by over half a million learners,English Practice is one of the world's most popular online English learning products. English Practice offers over 40,000 interactive 1essons for all levels of students who want to study and improve their English. Our structured content will help you improve your speaking,vocabulary,grammar,and your listening and written comprehension. And because English Practice is online,you can study at a pace and at a time that is convenient for you. How to Study When you start with English Practice we will give you a test to evaluate your language level. We will then recommend that you start as either a beginning intermediate or advanced learner. At each level you can take classes in General English,Work Skills,or Community to improve the skills you need. When you have completed enough lessons,we will give you another test and move you up to the next level. General English This is where you will find lessons to improve your grammar,listening comprehension,and vocabulary. There are new lessons weekly so you will always find new 1essons to this area you can also take lessons to prepare for TOEFL and IELTS. Work Skills This is where you can take lessons to teach you the specific skills you will need if you have to speak English at work,or do business in English. There are lessons on general business skills as well as courses to on specific industries. Community In the Community section you find English Practice's popular chat room,where you can practice with fellow students from around the world,and ask English teachers questions about English Community also has fun games like Bingo,Hangman,and Karaoke. As well as links to online English studying resources.", "neg": "Do you prefer British English or American English? Here are opinions from our readers. Andy: Well, being in British for 3 years now from New Zealand I've come to realize that a lot of British people pronounce words how Americans do. But in saying that, I guess the more educated British people do not pronounce words the way some Americans do. So, I prefer Educated British English. Bill: Well, I am studying English and I think British sounds funny and I prefer Americans sounds. Although I can tell that everyone else in my class loves British pronunciation and thinks American English is less pretty or even ugly. I don't agree at all, though. Cindy: At first British English accent sounds better and wonderful but then it gets annoying, so I love American English. Dale: I prefer the British accent. It sounds like someone reading a poem. I just like the pronunciation of the British people, very clear and sounds like music! British accent is more musical. Edward: When I listen to the BBC announcers, I notice that they're exploding the letters out, not pronouncing them. And some British people from the North of England or Scotland speak with strange accents. I mean it is difficult to understand their English. Frank: As a matter of fact, English for International Communication is very much like American accent. I love the American accent.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}308{"query": "I was small for my age. I was shy and sometimes it was hard for me to make friends with the others. However, learning came fairly easy for me. I was the best in most of my classes, but PE class was my nightmare and made me feel that I was not as good as the others. Miss Forsythe was our PE teacher. She was young and energetic. Everyone liked her. She said that we all had to come to her classes. No one could hide from Miss Forsythe! One day she told me that she wanted me to play a game with another girl in a PE show. I was rather worried that I wouldn't do a good job when she explained her idea, but she was excited. With her encouragement, I had no choice but to agree. It was a \"boy meets girl\" game. I played the boy and my classmate, Margaret Ann, played the girl. We were dressed in evening clothes and danced around the floor. According to Miss Forsythe, I had to pick up Margaret Ann when we finished the dance. Since I was not strong enough to pick the tallest girl up, it was she who picked me up. I suddenly felt ten feet tall! It was a huge success and everybody applauded for our excellent performance. What a wonderful ending! Afterwards, I smiled confidently . Miss Forsythe's understanding and willingness to create a place for me in her show (which certainly did not need me) gave me some much needed confidence. She was and always will be my favorite teacher.", "pos": "Six weeks after the death of her mother, Nancy Perkins' father (Thomas B. Henry) marries Doris (Jeanne Dean), and decides to enroll the eighteen-year-old Nancy (Sandra Harrison) into a boarding school, the Sherwood School for Girls. They are greeted by the principal, Mrs. Thorndyke (Mary Adams), who emphasizes to Nancy that the school is not a corrective institution but a private preparatory school with a very good reputation. Nancy is immediately harassed by her dormmates that night, and at breakfast the next morning, after Thorndyke officially introduces Nancy to the girls, Myra (Gail Ganley), their leader, tells Nancy that it was good thing that she did not mention anything about the way they acted the previous night. Myra also tells Nancy about their secret club, \"The Birds of Paradise,\" and introduces her to Eddie (Don Devlin), a young groundsman whom the \"Birds\" take turns dating. Myra is the assistant for Miss Branding (Louise Lewis), the school's chemistry teacher, who is writing a thesis about her belief that there is a \"terrible power,\" \"strong enough to destroy the world buried within each of us.\" If she can prove this is the case, she hopes that the scientific community will abandon their experiments with nuclear power and other weapons mass destruction. When Branding tells Myra that she is looking for a special girl on whom to experiment, Myra suggests Nancy. During chemistry class, Myra and her friend Nola (Heather Ames) deliberately switch a chemical in order to burn Nancy, causing her to react violently. Intrigued, Branding later talks with Nancy and gains her confidence. She then asks Nancy if she may hypnotize her and Nancy agrees. Branding places an amulet from antiquity around her neck, telling Nancy that it came from the Carpathian Mountain region and is capable of healing, as well as destroying and has the ability to release frightening powers. As Nancy gazes at the amulet, Branding hypnotizes her and instructs her to always obey her. Later, Eddie and two local boys, Tab (Jerry Blaine) and Joe (Jimmy Hayes), climb up into the girls' room as they are having Nancy's initiation party. In a nearby building, Branding hears the noise and, despite the distance, is able to re-hypnotize Nancy, turning her into a vampire. The party is broken up by the disciplinarian Miss Rivers (Edna Holland), who then sends Nola to the basement to fetch supplies. While in the basement, Nola is attacked by something subhuman and killed. The next morning, as police detective sergeant Stewart investigates the killing, Nancy is unable to wake up until Branding orders her and, when she relates a nightmare she had, Branding orders her to forget it. At police headquarters, the coroner informs Lt. Dunlap (Malcolm Atterbury) that he found two puncture wounds in Nola's jugular vein and that the body was drained of blood. A young assistant to the coroner, Mike (Paul Maxwell) who shared a room in med school with \"an exchange student from a small town in the Carpathian Mountains,\" remembers his friend's stories about vampires. Dunlap is unimpressed in the theory. The girls later organize a Halloween scavenger hunt in the local cemetery, and Nancy is again transformed into a vampire and kills another girl, as well as Tab. The police subject all the girls in the scavenger hunt to a lie-detector test, however, Branding is able to alter Nancy's responses to the questions by remote hypnosis. Back at the school, Nancy, confused and frightened by her transformations, begs for Branding's help, but Branding assures her that the experiment will soon be over and that she will be proud of her part in saving mankind from self-destruction. The state threatens to close the school over the unsolved murders, and consequently, Thorndyke asks Branding to take over some of her duties while she attempts to calm concerned parents. Nancy's boyfriend from back home, Glenn, suddenly arrives at the school, alarmed at the news stories of the slaughters but Nancy acts cold toward him afraid", "neg": "When we are unfamiliar with something,we may feel nervous and fearful.The assistance of others is a good way to help us pull through. I write for a big newspaper, and I wanted to write a story about parachute jumping.To make it a realistic as well as exciting story,I decided that I first had to make a jump myself. Unfortunately,I am not good at any sports of any kind,let alone parachute jumping. My friend Mr. Smith was willing to give me a hand.He took me to a ground school.The first day's training included several hours of instruction but not my first drop from an airplane For this,I had to wait until the following morning. The next morning,after a hurried,anxious breakfast,I was taken to the airfield.There,two heavy parachutes were put on my back,and an orange helmet was pushed down onto my head.Then I was asked to make my way to a small plane which had just stopped slowly on the runway. Once on board,the plane was soon climbing.I began to feel nervous.As we reached one thousand metres,Harry,my teacher, hooked a line from my parachute to a steel ring inside the plane.The line was to pull my parachute open after I jumped. \"Get ready, Henry,\"Harry said.I moved carefully to the door.I wanted to cry,\"No,no,no!\"But no word came. \"Jump!\"Harry called loudly.\"Jump!\" To my surprise,kicking like a frog I did jump.Away from the plane,and down,down I fell,arms stretched.It worked! The air seemed to hold me up.All at once I was very happy. Then I felt a quick pull.My big parachute had opened! It was the best surprise I ever had. I looked down.There were rivers,trees,fields and houses.I heard the soft sound of the air This was fun !", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}309{"query": "Back at home, the Dallas Cowboys traveled to Nashville to face off against the Titans. The Titans started their rookie quarterback Vince Young after veteran Kerry Collins produced dismal results after the first 3 games of the season. The Titans were able to score with a field goal on their opening drive making it the first time this season that they were able to score in the first quarter. The Titans were held to two field goals in the first half while the Cowboys had a lead at halftime with two 13-yard TD passes from Drew Bledsoe to WR Terry Glenn to put them up 14-6. The Cowboys continued to drive up the score during the 3rd quarter with a 5-yard touchdown run by RB Julius Jones. During this play Titans' DT Albert Haynesworth stepped on the face of Cowboys center Andre Gurode. Haynesworth was flagged for Unsportsmanlike Conduct and ejected from the game. He protested his ejection by taking off his helmet and throwing it on the ground. He was then flagged again with another Unsportsmanlike Conduct penalty. Gurode left the field with an ice pack to his face and required stitched above his left eye. He did not return to the field. Head Coach Jeff Fisher as well as Haynesworth later apologized for his actions. Vince Young connected for his second touchdown of the year to TE Ben Troupe. During the 4th quarter, the Cowboys scored on a field goal by Mike Vanderjagt. LB Brady James intercepted Vince Young's pass intended for Ben Troupe and returned it for a touchdown. The Cowboys sealed the win with a 7-yard TD run by Tyson Thompson with a final score of 45 to 14. The Cowboys moved to 2 and 1 while the Titans continued to losing streak dropping to 0-4.", "pos": "Hoping to rebound from a divisional home loss to the Eagles, the Cowboys flew to Bank of America Stadium for a Week 16 Saturday night duel with the Carolina Panthers. In the first quarter, Dallas shot first with QB Tony Romo completing a 10-yard TD pass to WR Terrell Owens for the only score of the period. In the second quarter, the 'Boys continued their assault as RB Marion Barber got a 5-yard TD run. The Panthers would get on the board with QB Matt Moore completing an 11-yard TD pass to WR Steve Smith. The Cowboys end the half with rookie kicker Nick Folk getting a 42-yard field goal. In the third quarter, Carolina started to try a comeback as kicker John Kasay getting a 37-yard field goal for the only score of the period. In the fourth quarter, Dallas would respond with Folk kicking a 23-yard field goal. The Panthers tried to rally as Kasay nailing a 25-yard field goal, yet the 'Boys were able to hold off every possible attempt. With the win, the Cowboys improved to 13-2 and clinched homefield through NFC Playoffs with Green Bay's loss to Chicago on Sunday. Terrell Owens (5 receptions for 48 yards and 1 touchdown) left the game in the second quarter with a high left ankle sprain.", "neg": "This game is well known for an infamous penalty that occurred during the overtime period. The Jets were lining up for a game winning 56-yard field goal in overtime to try and give them the win. Nick folk kicked the ball, but the kick went wide right and the Patriots appeared to be taking over with a chance to win. However, Chris Jones of New England was called for a controversial unsportsmanlike conduct penalty after pushing his teammate into the offensive line. This penalty would later be named \"leaping\". The penalty gave the Jets another chance and made the field goal attempt a 51-yard attempt. This time, Folk drilled the kick, and the Jets would go on to stun the Patriots. With the win, the Jets improved to 4-3.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}310{"query": "A rock under enough stress will fracture. There may or may not be movement along the fracture. If there is no movement on either side of a fracture, the fracture is called a joint. The rocks below show horizontal and vertical jointing. These joints formed when the confining stress was removed from the rocks as shown in (Figure If the blocks of rock on one or both sides of a fracture move, the fracture is called a fault (Figure 1.2). Stresses along faults cause rocks to break and move suddenly. The energy released is an earthquake. How do you know theres a fault in this rock? Try to line up the same type of rock on either side of the lines that cut across them. One side moved relative to the other side, so you know the lines are a fault. Slip is the distance rocks move along a fault. Slip can be up or down the fault plane. Slip is relative, because there is usually no way to know whether both sides moved or only one. Faults lie at an angle to the horizontal surface of the Earth. That angle is called the faults dip. The dip defines which of two basic types a fault is. If the faults dip is inclined relative to the horizontal, the fault is a dip-slip fault (Figure 1.3). There are two types of dip-slip faults. In a normal fault, the hanging wall drops down relative to the footwall. In a reverse fault, the footwall drops down relative to the hanging wall. This diagram illustrates the two types of dip-slip faults: normal faults and reverse faults. Imagine miners extracting a re- source along a fault. The hanging wall is where miners would have hung their lanterns. The footwall is where they would have walked. A thrust fault is a type of reverse fault in which the fault plane angle is nearly horizontal. Rocks can slip many miles along thrust faults (Figure 1.4). At Chief Mountain in Montana, the upper rocks at the Lewis Overthrust are more than 1 billion years older than the lower rocks. How could this happen? Normal faults can be huge. They are responsible for uplifting mountain ranges in regions experiencing tensional stress. A strike-slip fault is a dip-slip fault in which the dip of the fault plane is vertical. Strike-slip faults result from shear stresses. Imagine placing one foot on either side of a strike-slip fault. One block moves toward you. If that block moves toward your right foot, the fault is a right-lateral strike-slip fault; if that block moves toward your left foot, the fault is a left-lateral strike-slip fault (Figure 1.5). Californias San Andreas Fault is the worlds most famous strike-slip fault. It is a right-lateral strike slip fault (See opening image). People sometimes say that California will fall into the ocean someday, which is not true. Strike-slip faults. Click image to the left or use the URL below. URL:", "pos": "An earthquake is sudden ground movement caused by the sudden release of energy stored in rocks. Earthquakes happen when so much stress builds up in the rocks that the rocks rupture. The energy is transmitted by seismic waves. Earthquakes can be so small they go completely unnoticed, or so large that it can take years for a region to recover. The description of how earthquakes occur is called elastic rebound theory (Figure 1.1). Elastic rebound theory. Stresses build on both sides of a fault, causing the rocks to deform plastically (Time 2). When the stresses become too great, the rocks break and end up in a different location (Time 3). This releases the built up energy and creates an earthquake. Click image to the left or use the URL below. URL: In an earthquake, the initial point where the rocks rupture in the crust is called the focus. The epicenter is the point on the land surface that is directly above the focus (Figure 1.2). In the vertical cross section of crust, there are two features labeled - the focus and the epicenter, which is directly above the focus. Click image to the left or use the URL below. URL:", "neg": "Sedimentary rocks follow certain rules. 1. Sedimentary rocks are formed with the oldest layers on the bottom and the youngest on top. 2. Sediments are deposited horizontally, so sedimentary rock layers are originally horizontal, as are some vol- canic rocks, such as ash falls. 3. Sedimentary rock layers that are not horizontal are deformed. Since sedimentary rocks follow these rules, they are useful for seeing the effects of stress on rocks. Sedimentary rocks that are not horizontal must have been deformed. You can trace the deformation a rock has experienced by seeing how it differs from its original horizontal, oldest- on-bottom position. This deformation produces geologic structures such as folds, joints, and faults that are caused by stresses. Youre standing in the Grand Canyon and you see rocks like those in the Figure 1.1. Using the rules listed above, try to figure out the geologic history of the geologic column. The Grand Canyon is full mostly of sedimentary rocks, which are important for deciphering the geologic history of a region. In the Grand Canyon, the rock layers are exposed like a layer cake. Each layer is made of sediments that were deposited in a particular environment - perhaps a lake bed, shallow offshore region, or a sand dune. (a) The rocks of the Grand Canyon are like a layer cake. (b) A geologic column showing the rocks of the Grand Canyon. In this geologic column of the Grand Canyon, the sedimentary rocks of groups 3 through 6 are still horizontal. Group 2 rocks have been tilted. Group 1 rocks are not sedimentary. The oldest layers are on the bottom and youngest are on the top. The ways geologists figure out the geological history of an area will be explored more in the chapter Earth History. Click image to the left or use the URL below. URL:", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}311{"query": "In 2009 Fukushimas industries directly employed 18,678 workers and shipped 671 billion worth of goods. This was led by information-related industries with 50.5% of total output. Other industries in Fukushima include those dealing with food at 7.6% of total output, metals at 7.5%, chemistry at 5.3%, ceramics at 4.9%, electricity at 4.5%, printed goods at 2.8%, steel at 2.5%, plastics at 2.5%, and electronics at 2.2%. Other various industries make up the final 9.8%.", "pos": "Nations that have more industry produce more hazardous waste. Currently, the United States is the worlds largest producer of hazardous wastes, but China, which produces so many products for the developed world, may soon take over the number-one spot. Countries with more industry produce more hazardous wastes than those with little industry. Problems with haz- ardous wastes and their disposal became obvious sooner in the developed world than in the developing world. As a result, many developed nations, including the United States, have laws to help control hazardous waste disposal and to clean toxic sites. As mentioned in the \"Impacts of Hazardous Waste\" concept, the Superfund Act requires companies to clean up contaminated sites that are designated as Superfund sites (Figure 1.1). If a responsible party cannot be identified, because the company has gone out of business or its culpability cannot be proven, the federal government pays for the cleanup out of a trust fund with money put aside by the petroleum and chemical industries. As a result of the Superfund Act, companies today are more careful about how they deal with hazardous substances. Superfund sites are located all over the nation and many are waiting to be cleaned up. The Resource Conservation and Recovery Act of 1976 requires that companies keep track of any hazardous materials they produce. These materials must be disposed of using government guidelines and records must be kept to show the government that the wastes were disposed of safely. Workers must be protected from the hazardous materials. To some extent, individuals can control the production and disposal of hazardous wastes. We can choose to use materials that are not hazardous, such as using vinegar as a cleanser. At home, people can control the amount of pesticides that they use (or they can use organic methods of pest control). It is also necessary to dispose of hazardous materials properly by not pouring them over the land, down the drain or toilet, or into a sewer or trashcan. Click image to the left or use the URL below. URL:", "neg": "Nuclear-powered aircraft carriers are considered one of the most important marine weapons in the 20th century. So far, only two countries in the world--the prefix = st1 /USAandFrance--have ever produced them. But these frightful fighting machines are about to enter Asia. The US Navy said last month that one of its nine nuclear-powered aircraft carriers will be sent to Japanto replace the diesel-powered carrier Kitty Hawk in 2009 in an agreement on October 30th. The two countries also planned to level up their military cooperation and theUSAcalled forJapanto take a large role in alliance military moves. It will be the first time that a nuclear-powered carrier is based in Japan. Bombed byUSforces in World War II at Hiroshima and Nagasaki,Japanis the only world country to have been attacked by a nuclear weapon. Therefore, the citizens are highly sensitive to where nuclear-powered weapons are based. \"A radiation leak at Yokosuka would kill 100,000 people as far away as Tokyo, and could cause billions of dollars in damage,\" said Masahiko Go to, leader of a protest group inYokosuka. His group has collected more than 300,000 signatures of people acrossJapanopposed to the nuclear carrier. The 44-year-old Kitty Hawk, the USnavy's oldest active ship, has been based in Yokosuda since 1998. The new carrier, yet to be _ , will travel faster, be capable of supporting longer operations and carry with it the Navy's most modern technology. Experts pointed that this change is not only to strengthen the US-Japan military alliance but also to keep the military power of ChinaandNorth Koreawithin limits. However, Japanese experts don't believe that the countries are threats to the region. \"There is no need for Japanto have a nuclear carrier as defense,\" said Tetsuo Maeda, an international relations professor atTokyoInternationalUniversity. He said that the change of ship indicates an increased military capacity, in the region, much more than what is needed.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}312{"query": "Online Chess Kingdoms is a chess simulation game for the PlayStation Portable released by Konami in 2006 in North America and 2007 in Europe.", "pos": "Skulls of the Shogun is a turn-based tactics video game developed by 17-BIT.", "neg": "The ZBD-97, or Type 97, has been in service with the PLA ground forces since 2006, in the armored units of the Guangzhou and Nanjing military regions.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}313{"query": "Ron Bozman is an American film producer who won an Academy Award for Best Picture in 1991 for the film The Silence of the Lambs.", "pos": "Grant Heslov (born May 15, 1963) is an American actor, film producer, screenwriter and director, known for producing Argo (2012) for which he received an Academy Award for Best Picture as co-producer in 2013.", "neg": "Forbidden Paradise is a 1924 American silent drama film produced by Famous Players-Lasky and distributed by Paramount Pictures.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}314{"query": "Riociguat (Adempas(®)), an oral first-in-class soluble guanylate cyclase (sGC) stimulator, is under global development by Bayer Healthcare Pharmaceuticals Inc. for the treatment of adult patients with inoperable or chronic/persistent chronic thromboembolic pulmonary hypertension (CTEPH) and for the treatment of adult patients with pulmonary arterial hypertension (PAH). The drug directly stimulates sGC in a nitric oxide independent manner, thereby increasing the sensitivity of sGC to nitric oxide, leading to increased cyclic guanosine monophosphate generation (a key signalling molecule involved in regulating vascular tone, proliferation, fibrosis and inflammation). Riociguat is the world's first approved pharmacotherapy for CTEPH, with its first global approval in this indication occurring in Canada. It has subsequently been approved in the USA for the treatment of patients with CTEPH and also received its first global approval in patients with PAH in the USA. It is undergoing regulatory review for these indications in Europe and for use in patients with CTEPH in Japan. This article summarizes the milestones in the development of riociguat, leading to its first global approvals in patients with CTEPH and PAH.", "pos": "Riociguat (Adempas(®)), a soluble guanylate cyclase stimulator, is a new, first-in-class drug approved for the treatment of patients with chronic thromboembolic pulmonary hypertension (CTEPH) [inoperable or persistent/recurrent following surgery] or pulmonary arterial hypertension (PAH). It has been designated an orphan medicine by the European Medicines Agency and the US FDA. This article reviews the available pharmacological properties of oral riociguat and its clinical efficacy and tolerability in adults with CTEPH or PAH. Riociguat is effective and well tolerated in patients with inoperable CTEPH or persistent/recurrent CTEPH following pulmonary endarterectomy, and in patients with PAH. It has a positive result on exercise capacity and pulmonary haemodynamics, and improves WHO functional class. Most adverse events can be attributed to the vasodilatory mechanism of riociguat; however, there is a potential for serious bleeding and fetal harm, and riociguat use is contraindicated in pregnant patients. Pulmonary endarterectomy remains the first treatment of choice for CTEPH, as it is potentially curative. Head-to-head trials comparing riociguat with the approved phosphodiesterase type 5 inhibitors in patients with PAH would be of value for the placement of riociguat in the management of this disease. Riociguat is a promising addition to the treatment options for patients with CTEPH or PAH.", "neg": "One of the major histopathological hallmarks of Alzheimer's disease (AD) is cerebral deposits of extracellular -amyloid peptides. Preclinical studies have pointed to glucagon-like peptide 1 (GLP-1) receptors as a potential novel target in the treatment of AD. GLP-1 receptor agonists, including exendin-4 and liraglutide, have been shown to promote plaque-lowering and mnemonic effects of in a number of experimental models of AD. Transgenic mouse models carrying genetic mutations of amyloid protein precursor (APP) and presenilin-1 (PS1) are commonly used to assess the pharmacodynamics of potential amyloidosis-lowering and pro-cognitive compounds. In this study, effects of long-term liraglutide treatment were therefore determined in two double APP/PS1 transgenic mouse models of Alzheimer's disease carrying different clinical APP/PS1 mutations, i.e. the 'London' (hAPPLon/PS1A246E) and 'Swedish' mutation variant (hAPPSwe/PS1E9) of APP, with co-expression of distinct PS1 variants. Liraglutide was administered in 5 month-old hAPPLon/PS1A246E mice for 3 months (100 or 500 ng/kg/day, s.c.), or 7 month-old hAPPSwe/PS1E9 mice for 5 months (500 ng/kg/day, s.c.). In both models, regional plaque load was quantified throughout the brain using stereological methods. Vehicle-dosed hAPPSwe/PS1E9 mice exhibited considerably higher cerebral plaque load than hAPPLon/PS1A246E control mice. Compared to vehicle-dosed transgenic controls, liraglutide treatment had no effect on the plaque levels in hAPPLon/PS1A246E and hAPPSwe/PS1E9 mice. In conclusion, long-term liraglutide treatment exhibited no effect on cerebral plaque load in two transgenic mouse models of low- and high-grade amyloidosis, which suggests differential sensitivity to long-term liraglutide treatment in various transgenic mouse models mimicking distinct pathological hallmarks of AD.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}315{"query": "Nobrega, Manuel da, S.J., and Leit, Serafim. Cartas. Coimbra Universidade, 1955. Secondary Sources Cohen, Thomas. \"'Who is My Neighbor?' The Missionary Ideals of Manuel da Nobrega.\" JesuitEncounters in the New World: Jesuit Chroniclers, Geographers, Educators and Missionaries in the Americas, 1549-1767. Ed. Gagliano, Joseph A., Ronan, Charles E., S.J. Instituto Storico S.I.: Roma, 1997. Dominan, Helen G. Apostle of Brazil. New York: Exposition Press, 1958. Domingues, Beatriz Helena. \"Comparing Colonial Cultural experiences: Religious Syncretism inBrazil, Mexico and North America.\" Revista Electronica de Historia do Brasil. V.2. n. 2. Jul/Dec 1998. Schwartz, Stuart B. Sugar Plantations in the Formation of Brazilian Society: Bahia, 1550-1835.", "pos": "Simao Rodrigues de Azevedo (1510, Vouzela, Portugal - 15 June 1579, Lisbon), was a Portuguese Jesuit priest, , one of the co-founders of the Society of Jesus.", "neg": "Brazil is a federation that consists of twenty-six states and one federal district. The biggest majority of Brazil's population belongs to the Christian religion and almost all of them are Catholics. This is something Brazil inherited being Portugal's colony . Historically, the country was a colony claimed by people from Portugal and this made Portuguese the official language. The Portuguese reached Brazil in 1500 and until that moment it was inhabited by semi-nomadic people. The Portuguese changed Brazil into a country of slaves until 1800, when Maria I of Portugal came to live in Brazil. The Queen did not stay long in Brazil, but during the 20 years of royal presence a lot of changes occurred: commercial ports to United Kingdom were opened; Brazil stopped being isolated from other countries. So at the moment of getting the independence on the 7th of September, 1822, Brazil already had the potential to develop. The Brazilian Empire, Pedro I, abolished slavery in 1888 in the face of Princess Isabel. A lot of European people started coming to Brazil and the industry of the country started working. In the 19th and the 20th century as it has been said above foreign people immigrated to Brazil and basically 5 million European and Japanese people became the residents of Brazil. The beginning of the 20th century was especially marked by the immigration of a lot of Asian people: Japanese, Korean and Chinese immigrants. As a matter of fact Japanese people do not immigrate a lot, and the fact that the Brazilian-Japanese people are the largest Japanese minority in the world does astonish greatly. The majority of the cultural inherits of Brazil are actually Portuguese, due to the fact that Brazil was Portugal's colony for a very long time. The southern states mainly consist of European population and the north and the northeast consist of a mixed population including Africans, Amerindians and Europeans. Most of this population is Roman Catholic. No other country in the world has the same amount of Catholics. The modern tendency of Brazil is the growing number of people calling themselves Protestants. Around 7.4% of the population don't believe any god. Some Brazilians, especially in the northern states are mixed Africans who prefer following the traditional African religions. Only 1.8% of the population chose Buddhism, Islam or Judaism. Though Brazil always tried to maintain democracy, it was failed several times by the dictatorship of Getulo Vargas. This fact could not affect the political situation in the country.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}316{"query": "Sports City Stadium is a proposed football stadium which will be built in Doha, Qatar in time for the 2022 FIFA World Cup in Qatar.", "pos": "Estadio Alberto Gallardo is a football stadium in the San Martin de Porres District of Lima, Peru, current home ground of the football club Sporting Cristal.", "neg": "Athens will welcome the 2004 Olympic Games with open arms. Not only will the Games be returning to their birthplace, but they'll also be entering a new period of Olympic history. The International Olympic Committee (IOC) has been looking for ways to make the world's largest sporting event a bit smaller and easier for cities to host. Mexico is the only Latin American nation to have hosted the Olympics. And the games have never been held in Africa. It costs well over$4 billion to host the Olympic Games. And this is stopping many poorer countries from trying to win the bid. Cities in Africa and Latin America, with great social and money problems, cannot even begin to make the bid. So, the IOC has suggested 117 ways to make the Games smaller and easier for cities across the world. These ideas are to be put into practice soon---maybe in time for the Beijing 2008 Olympics. The IOC wants to save up to $400 million. The suggestions include limiting the number of sports to 28 and the number of athletes to 10,500. \"Imagine a bus with 28 seats and some sports need to get off to give their places to other sports,\"said an IOC official. Sports that might not appear in the 2008 Beijing Olympic Games included baseball, softball and the modern pentathlon (shooting, fencing, horse, jumping, swimming and running). \"We think that the Olympic Games have to be made smaller, and the less costly so that they can be organized by all continents and subcontinents ,\"said IOC president Jacques Rogge. \"Our dream is that a continent such as Africa will be able to organize the Olympic Games.\"", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}317{"query": "Jango Fett is a fictional character in the Star Wars universe created by George Lucas.", "pos": "Darth Bane is a fictional character in the Star Wars Expanded Universe.", "neg": "''Anymore'' is a song co-written and recorded by American country music artist Travis Tritt.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}318{"query": "According to a survey released by the Nielson Company on Thursday, China has become a global tourist attraction after the Beijing Olympics. The survey said the Olympics not only built up China's image but also served as an advertisement for China's tourism. The online survey was conducted on consumers in 16 countries and regions before Games' opening ceremony and after the closing. About 80 percent of the respondents had not been to China before the events and 50 percent of them expressed hopes of visiting China after the Games. According to the survey, 70 percent of the respondents felt Beijing was more modern and scientific than what they had thought. The most interested respondents were from Singapore, India, Mexico, South Africa and the Republic of Korea, as well as China's Hong Kong and Taiwan. Pan Wen, in charge of Chinese tourism research of the Nielson Company, said the World Tourism Organization predicted that China would become the largest tourist attraction in the world with 137 million foreign tourists every year. \"This figure would be realized earlier with the aid of the Beijing Olympics,\" Pan said.", "pos": "From Britain to the Middle East and China, engineers and architects are pushing the boundaries of possibility as they strive to create the biggest and the best. Here are recently-selected seven wonders-to-be in the modern world which are near completion. Among these, Beijing Daxing International Airport ranks the first and Hong Kong-Zhuhai-Macau Bridge ranks the third. No.1 Beijing Daxing International Airport, China Beijing Daxing International Airport, which is set to be the biggest airport in the world, is designed by Iraqi-British architect Zaha Hadid. The new Terminal One will have a radial-like plan, designed to reduce passenger travel distances. The construction of the new airport started in 2015 and it is planned to be put into use in 2019. No.2 Kingdom Tower, Jeddah, Saudi Arabia Adrian Smith, the architect who has designed the highest structure in the world, the 829.8 m-high Burj Khalifa in Dubai, is now working on his new project which will smash his own record by this over-a-kilometer-high Kingdom Tower in Jeddah, Saudi Arabia. No one can be sure about the exact date of its completion but most probably the project will be ended in 2019. No.3 Hong Kong-Zhuhai-Macau Bridge, China At about 50 km long, Hong Kong-Zhuhai-Macau Bridge will take the title of the longest water span in the world from another China's bridge in Jiaozhou Bay. The construction started in 2009 and will complete the first session in 2017. No.4 Chernobyl reactor, Ukraine The engineers of the USSR who fought to bring the Chernobyl disaster under control built a concrete sarcophagus to cover the hole that had opened up above the destroyed reactor. A new steel arched structure is being built, to be rolled on rails over the reactor, from which point demolition work can begin using cranes suspended from the new roof. Most possibly it will be finished in 2020. No.5 Hotel Abraj Kudai, Mecca Every hajj, Mecca receives more than two million pilgrims from all over the world. New buildings are being built to accommodate these pilgrims. The Abraj Kudai cluster of towers will hold more than 10,000 hotel rooms. It is expected that the construction work will be put an end to in 2017. No.6 Crossrail, London Crossrail is built to link east and west London through the sewers, cables, and the city's foundations. After its completion in 2017, it is expected to alleviate traffic jams in London. No.7 Grand Stade FFR, Paris Grand Stade FFR is designed especially for the French Rugby Federation. The stadium can accommodate 82,000 fans and is dotted with retractable pitches (a marked out area of ground on which a sport is played). A retractable roof apparatus is capable of turning the stadium into a giant interior. Hopefully the fans can gather there to watch thrilling matches in 2018.", "neg": "A total of about 790,000 tickets were put on sale from February 2015 online, at the Singapore Indoor Stadium and at SingPost outlets. To encourage public participation in the games, it was announced on 28 January 2015 that 18 of the sports will be free for spectators, while the other 18 are kept at relatively affordable levels of between S$5 to S$20. By 15 April 2015 some sports such as swimming and fencing were selling fast, while silat and sepak takraw were much less popular. Organisers reported that ticket sales were pass 70% for most sports by 27 April, with fencing and swimming being the most popular at 85 and 70% tickets sold respectively, while rhythmic gymnastics, silat and wushu have also sold over 70%. Billiards and snooker, equestrian, sepak takraw, taekwondo, and artistic gymnastics have sold about half their tickets. Rugby and judo have sold 30%, while table tennis has sold only 20%. Priced between S$5 to S$20, priority sales for the opening and closing ceremonies tickets for those who registered theirs interests in 2014 began on 15 January 2015, while sales for the general public began on 22 January 2015. In February 2015, tickets to the opening ceremony were going at over seven times their original value on unauthorised websites, despite 40% of the tickets still available at that time. By March 2015, tickets to the opening ceremony were sold out.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}319{"query": "The evolutionarily conserved histone variant H2A.Z has an important role in the regulation of gene expression and the establishment of a buffer to the spread of silent heterochromatin. Saccharomyces cerevisiae Swr1, a Swi2/Snf2-related ATPase, is the catalytic core of a multisubunit chromatin remodeling enzyme, called the SWR1 complex, that efficiently replaces conventional histone H2A in nucleosomes with histone H2A.Z. Swr1 is required for the deposition of histone H2A.Z at stereotypical promoter locations in vivo, and Swr1 and H2A.Z commonly regulate a subset of yeast genes. Here, we describe an integrated nucleosome assembly-histone replacement system whereby histone exchange by chromatin remodeling activities may be analyzed in vitro. The system demonstrates ATP- and SWR1-complex-dependent replacement of histone H2A for histone H2A.Z on a preassembled nucleosome array. This system may also be adapted to analyze dynamic interactions between chromatin remodeling and modifying enzymes, histone chaperones, and nucleosome substrates containing canonical, variant, or covalently modified histones.", "pos": "Histone variant H2A.Z-containing nucleosomes are incorporated at most eukaryotic promoters. This incorporation is mediated by the conserved SWR1 complex, which replaces histone H2A in canonical nucleosomes with H2A.Z in an ATP-dependent manner. Here, we show that promoter-proximal nucleosomes are highly heterogeneous for H2A.Z in Saccharomyces cerevisiae, with substantial representation of nucleosomes containing one, two, or zero H2A.Z molecules. SWR1-catalyzed H2A.Z replacement in vitro occurs in a stepwise and unidirectional fashion, one H2A.Z-H2B dimer at a time, producing heterotypic nucleosomes as intermediates and homotypic H2A.Z nucleosomes as end products. The ATPase activity of SWR1 is specifically stimulated by H2A-containing nucleosomes without ensuing histone H2A eviction. Remarkably, further addition of free H2A.Z-H2B dimer leads to hyperstimulation of ATPase activity, eviction of nucleosomal H2A-H2B, and deposition of H2A.Z-H2B. These results suggest that the combination of H2A-containing nucleosome and free H2A.Z-H2B dimer acting as both effector and substrate for SWR1 governs the specificity and outcome of the replacement reaction.", "neg": "The organization of chromatin into higher-order structures influences chromosome function and epigenetic gene regulation. Higher-order chromatin has been proposed to be nucleated by the covalent modification of histone tails and the subsequent establishment of chromosomal subdomains by non-histone modifier factors. Here we show that human SUV39H1 and murine Suv39h1--mammalian homologues of Drosophila Su(var)3-9 and of Schizosaccharomyces pombe clr4--encode histone H3-specific methyltransferases that selectively methylate lysine 9 of the amino terminus of histone H3 in vitro. We mapped the catalytic motif to the evolutionarily conserved SET domain, which requires adjacent cysteine-rich regions to confer histone methyltransferase activity. Methylation of lysine 9 interferes with phosphorylation of serine 10, but is also influenced by pre-existing modifications in the amino terminus of H3. In vivo, deregulated SUV39H1 or disrupted Suv39h activity modulate H3 serine 10 phosphorylation in native chromatin and induce aberrant mitotic divisions. Our data reveal a functional interdependence of site-specific H3 tail modifications and suggest a dynamic mechanism for the regulation of higher-order chromatin.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}320{"query": "The RTS,S/AS01(E) malaria vaccine candidate has recently entered Phase 3 testing. Reaching this important milestone is the culmination of more than 20 years of research and development by GlaxoSmithKline and partners and collaborators. The vaccine has been developed to protect young children and infants living in Sub-Saharan Africa against clinical and severe disease caused by Plasmodium falciparum infection. Over the past 9 years, RTS,S/AS has been evaluated in multiple Phase 2 studies. The vaccine was shown to have a favorable safety profile and to be well tolerated in all age groups in which it was tested, including the intended target population of infants and young children in Sub-Saharan Africa. Data obtained so far suggest that RTS,S/AS can be co-administered with other vaccines included in the routine Expanded Program of Immunization (EPI). In Phase 2 testing, the vaccine candidate was shown to confer significant protection against P. falciparum infection and clinical disease, including severe malaria. Furthermore, a trend towards an indirect beneficial effect of the vaccine on non-malarial morbidities has been observed in several trials. In this paper, we will describe the genesis of the RTS,S/AS concept, including the rationale for selecting the circumsporozoite protein (CSP) as the target antigen. Early development history of the vaccine will be briefly described. We will present the most salient results from recent Phase 2 studies conducted in the target pediatric population, which have led to the decision to progress RTS,S/AS to Phase 3 testing. If the Phase 3 results confirm the observations made during Phase 2 testing, the RTS,S/AS vaccine, when broadly implemented and judiciously integrated with other malaria-prevention measures, would have a major public-health impact in Sub-Saharan Africa.", "pos": "This review paper describes the development of the RTS,S/AS vaccine, from concept to phase III testing. The rationale for selection of the circumsporozoite protein (CSP) as the target antigen and the preclinical development history of the vaccine are described. The RTS,S/AS candidate vaccine has been evaluated in multiple phase I/II studies and was shown to have a favorable safety profile and to be well tolerated in both adults and children. Consistent and significant efficacy has been observed in the target population of infants and children against Plasmodium falciparum infection and disease in different transmission settings, in different age groups, with or without Expanded Program of Immunization (EPI) vaccine co-administration. The RTS,S/AS01(E) malaria vaccine candidate has recently entered phase III testing. Reaching this important milestone is the culmination of more than 20 years of research and development by GlaxoSmithKline, their partners and collaborators. If the phase III results confirm the observations made during phase II testing, the RTS,S/AS01(E) vaccine, when broadly implemented and judiciously integrated with other malaria-prevention measures, would have a major public-health impact in sub-Saharan Africa.", "neg": "Malaria is a major human health problem and is responsible for over 2 million deaths per year. It is caused by a number of species of the genus Plasmodium, and Plasmodium falciparum is the causative agent of the most lethal form. Consequently, the development of a vaccine against this parasite is a priority. There are a number of stages of the parasite life cycle that are being targeted for the development of vaccines. Important candidate antigens include proteins on the surface of the asexual merozoite stage, the form that invades the host erythrocyte. The development of methods to manipulate the genome of Plasmodium species has enabled the construction of gain-of-function and loss-of-function mutants and provided new strategies to analyse the role of parasite proteins. This has provided new information on the role of merozoite antigens in erythrocyte invasion and also allows new approaches to address their potential as vaccine candidates.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}321{"query": "The film opens in the early 1970s in front of the Quick Stop Groceries and the Record Rack stores in Leonardo, NJ. A kindly mother leaves a stroller with her toddler son, Bob, in front of the store while she goes inside to buy food. She gives the boy a baseball cap that she puts on his head with the visor turned backwards. Another mother, more foulmouthed and demeaning toward her own toddler, Jay, leaves her stroller in front of the store while she goes into the record store to score drugs. A man walks out & asks her who'll be watching the kids while their mothers are inside. The woman lets loose with a torrent of foul language, laced liberally with the F-word, attacking the man for questioning how she raises her kid. The guy walks away, disgusted The child of the foul-mouthed mother stands up in his stroller and begins to recite the F-word in rhythmic fashion and the scene dissolves to the two boys as young adults; they have grown up to become the foul-mouthed Jay and his taciturn companion, Silent Bob. The duo stand in front of the stores (the Quick Stop is still there but the record store has changed to RST Video) most days and deal drugs. When a couple of teenagers approach them, Jay launches into a rap sales pitch reminiscent of Morris Day & the Time's \"Jungle Love\". When the younger teen derides the song, Jay grabs him and threatens him. From the video store, Randal Graves appears and tells Jay and Bob to let the kid go and that the Time sucked anyway. Jay tells the two buyers that Randal and his coworker, Dante Hicks, are both a gay couple and that their wedding ceremony was Star Wars-themed. Randal says he'll do something that should've been done long ago: he calls the police. Jay and Bob are arrested after Jay mouths off to the cop.Jay and Bob go to the comic book store that bears their name to talk to Banky. They've been slapped with a restraining order that forbids them to go to either Quick Stop or RST. Banky tells them both that they shouldn't have to bother selling drugs anymore because of the royalties they received when the comic series they inspired, Bluntman and Chronic, was sold to a major motion picture studio. The two are stunned, saying they didn't know about the deal. Banky tells them both that they should talk to his old business partner, Holden McNeil, who brokered the deal after he'd bought Banky out of his share of the original comic.The two go to Holden's offices and confront him about the movie. Holden tells them that Banky had lied to them and had brokered the deal, leaving Holden with nothing. He also says that the buzz on the internet is that the movie will be very profitable. Jay and Bob are both clueless as to the existence of the internet and Holden shows them an example of a forum website where fans and non-fans of Bluntman and Chronic are sharing their views on the unfinished film. Jay and Bob are furious at the negative buzz and make it their mission to go to Hollywood and stop the production of the film.Without a car, the two decide to hitchhike. After receiving advice from an expert hitchhiker where he tells them to perform sexual favors for rides, the two are picked up by a nun. She throws them both out of her car when Jay suggests that the Rules of the Road require him to pay her with oral sex. Stranded in front of a Mooby's restaurant, they go inside to get something to eat. They find an internet station and launch a foul-mouthed response to their detractors on Moviepoopshoot.com. While they order their food, a beautiful woman, Justice, walks in. Jay is immediately smitten and imagines kissing her to Bon Jovi's \"Bad Medicine.\" After they introduce themselves, they hitch a ride with Justice and her two companions, Chrissy and Sissy. Also joining them is a geeky guy with a guitar, named Brent. Justice tells them that she and her comrades are animal rights activists who travel", "pos": "Images from the first part of Porky.Edward \"Pee Wee\" Morris (Dan Monahan) wakes up shouting \"I've been laid!\" with joy. It's the following morning, after all the events in the first part. He increases the line in his maturity chart - the one he keeps under his mattress. His penis doesn't look as responsive as always, but he thinks it may be a resting time after the novelty of sex with a woman. His mother (Ilse Erl) enters his bedroom while he's got a boner - after watching toples women at The National Geographic magazine. Mrs Morris is dumbfolded when she looks at Pee Wee's chart.Back at Angel High School, Pee Wee brags about having Wendy Williams (Kaki Hunter) snatched from everybody else. His friends tease Pee Wee, saying that Wendy didn't think it was such a big thing. Wendy wants a better man - Wendy admits that it was all a prank planned by his friends: she really ended up satisfied.The Drama Club is producing a Shakespeare-based play for a theatre festival. All the boys in the festival are participating. Pee Wee interrupts a natural sciences lesson - the vivisected frogs are disgusting. Pee Wee is blamed for a joke which was not even his, but the science teacher (Howard Neu) tells him off. Pee Wee is jealous of Wendy, who is talked about a lot. She says that she's faithful, that people will talk about her without really knowing her, and that boys will always brag about things they haven't really done. Pee Wee tries to trust her, and says that he'll kick the ass of any boy who badmouths her from that moment on.Tommy Turner (Wyatt Knight), Tim Cavanaugh (Cyril O'Reilly), Billy McCarthy (Mark Herrier) and Anthony \"Meat\" Tuperello (Tony Ganios) are part of Pee Wee's gang. They are on friendly terms with new student Johnny Henry (Joseph Runningfox), who says hello to them. He'll participate in Shakespeare's play as well, alongside with Pee Wee and Tommy.Anthony has to dress up as a god fairy, which creates plenty of mockery around, especially with Pee Wee. Later, they disguise themselves to go to a carnival to see a well-endowed girl to dance something similar to the dance of the seven veils. The boys visit Gloria , and her MC (Peter Conrad). Pee Wee wants to get out on stage with his costume. He looks like a green Puck.Ms Beulah Balbricker (Nancy Parsons) and Reverend Bubba Flavel (Bill Wiley). Mrs Morris, Pee Wee's mother was the person responsible for the play. Mr. Floyd J. Carter (Eric Christmas) cannot stand up to Flavel's shouts and screams. They allege that Shakespeare is filth. Carter dismisses them after reading romantic passages from the Bible.Pee Wee finds another girl, and he takes her to the cemetery. He runs away. It's a prank - as Pee Wee shows himself stark naked. Laura gets undressed and wraps herself around Pee Wee. It looks like Laura is choking to death. Steve and Tommy say that Pee Wee is to blame for Laura's death. They can't call Ted (Art Hindle). Steve frightens Pee Wee, dressed as a zombie. So now, they accuse Pee Wee of killing two people; he runs butt naked. Ted and another cop see Pee Wee naked running on the road, but they don't stop to pick him up. They are dumb folded by Steve's disguise, but not afraid. He passes out.Somebody (Will Knickerbocker) has thrust a dummy against Johnny Henry, a Native American, kissing a white girl. The commissioners arrive; they are Hurley (Fred Buch), Couch (Richard Liberty) and Gebhardt (Edward Winter) will support the play, in spite of the racist comments.Balbricker sings and dances Black Magic while on the toilet, but the gang plays a prank on her. They open up the pipe and push a snake up. Balbricker runs in panic with her pants", "neg": "Parents are lectured about the dangers of their children using marijuana with a cautionary tale of what happened to once-innocent kids became addicted to the drug: their mind alterations lead to a car accident, a shooting, and an innocent boy being brought to trial.--------------------------------------------------Synopsis written by KrystelClaire:A long written essay against marijuana.Newspaper reels and first pages telling of how the police is tackling the issue of the marijuana war. In one of them, there is an advertisement telling parents to attend Alfred Carroll (Josef Forte)'s lecture at the School-Parents Association in Truman high school auditorium. He mentions that marijuana was grown in a tenement court in New York.Cut to Mae (Thelma White) who is woken up rudely by Pete Daley (Richard Alexander) who wants to lure kids into criminality. Three friends separate. Ralph (Dave O'Brien) points to some attractive young women. The girl Ralph wants most is Jimmy Harper (Warren McCullom)'s sister. Bill (Kenneth Craig) thinks she's interested as well. They go to a jazz place, where Mae sits uncomfortably as she knows that the real objective is to lure kids into drugs. The audience can see Ralph smoking like crazy in a separate room. The say goodbye to Joe (Lester Dorr), the bartender.Mary (Dorothy Short) takes Jimmy home, where Mrs Lane (Mary MacLaren) is happy to see them performing Shakespeare in a ridiculous way. When they kiss, she intervenes. Jimmy says goodbye and falls into a fountain garden. Junior (Bob Burns) laughs about Jimmy having a girlfriend.Ralph and Jimmy go partying. Mae distributes marijuana cigarettes - her husband is delighted that he already has a new kid in the bag: Jimmy. Mary encourages Jimmy to smoke. Ralphs laughs like a maniac: he knows he's succeeded. He goes to see Jack (Carleton Young), who thinks that kids are the best prey - now we would consider young adults, he doesn't mean children. Jimmy drives while high on dope. He scares Jack with his reckless driving and runs over a man.When Jimmy arrives home, it's dinner time. He is shocked, and tired, and his sister notices, but not his mother. Mr Wayne (Edward Earle) thinks that there marijuana is not as dangerous as other drugs, in spite of Mr Carroll's insistence.Jimmy's grades are much worse. Dr Carroll tries to make him confide on him, but Jimmy says that he's worried about a home problem, and just leaves. Mary doesn't play tennis. Jimmy dances at Mae's while he's high. Jimmy makes love to a girl while Ralph laughs like a maniac.The police questions Jimmy's sister if she used her car on the 29th. Mary lies to protect him. Joe gives Mary the address where Jimmy is. Mary sits to wait for Jimmy, and Mae's husband offers her a marijuana cigarette, which she smokes without realising it's not tobacco she's using. Mary starts laughing for no reason. Mary rejects Pete Daley), but Jimmy, completely doped, at first believes that they are making love. When he intervenes, there is a fight between Ralph and Jimmy. In the ensuing fight, the gun which Ralph uses goes off and kills Mary. Ralph dusts the gun off and puts it into Jimmy's hand, who's still doped. When they wake him up, they make him believe that he killed Mary.Jack prepares an alibi for himself. Carroll declares in front to the judge and jury that he's seen Jimmy very much changed, and that marijuana was to blame. The Judge (Edward LeSaint) presides. The jurors (Marin Sais, Phil Dunham) stare at the declarations in shock. Blanche (Lillian Milles) feels sorry for Jimmy, but Jack tells her to shut up.The prosecuting attorney (William Royle) blames marijuana as the cause of the murder. Jimmy is in shock. One of the jurors thinks that Jimmy may have been insane, but the foreman (Frank O'Connor) makes a case for all the opposite: they want to hang Jimmy Harper as soon as possible", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}322{"query": "Hypospadias, when the urethra opens on the ventral side of the penis, is a common malformation seen in about 3 per 1,000 male births. It is a complex disorder associated with genetic and environmental factors and can be part of genetic syndromes. Mowat-Wilson syndrome (MWS) is a multiple congenital anomaly syndrome characterized by a distinct facial phenotype, Hirschsprung disease, microcephaly and mental retardation. It is caused by mutations in the zinc finger homeo box 1B gene, ZFHX1B (SIP1). To date, 68 deletion/mutation-positive cases have been reported. Genitourinary anomalies are common in MWS. Here we report that hypospadias is common in males with this syndrome. In 39 patients where this information was available, hypospadias was present in 46% of patients (18/39). In the 3 Italian male cases reported here, hypospadias was always present. MWS should be considered by endocrinologists in patients with hypospadias associated with developmental delays/mental retardation, in particular in the presence of a distinct facial phenotype.", "pos": "Mowat-Wilson syndrome (MWS) is a rare mental retardation-multiple congenital anomalies syndrome associated with typical facial dysmorphism. Patients can show a variety of other anomalies like short stature, microcephaly, Hirschsprung disease, malformations of the brain, seizures, congenital heart defects and urogenital anomalies. Mutations leading to haploinsufficiency of the ZFHX1B gene have been described as the underlying cause of this condition. We report on the clinical findings in a 2(1/2)-year-old boy with some aspects out of the MWS-spectrum in addition to unusual anomalies and a novel missense mutation in the ZFHX1B gene.", "neg": "Sometimes, the urinary system ( Figure 1.1) is called the excretory system. But the urinary system is only one part of the excretory system. Recall that the excretory system is also made up of the skin, lungs, and large intestine, as well as the kidneys. The urinary system is the organ system that makes, stores, and gets rid of urine. 1. As you can see above ( Figure 1.1), the kidneys are two bean-shaped organs. Kidneys filter and clean the blood and form urine. They are about the size of your fists and are found near the middle of the back, just below your ribcage. 2. Ureters are tube-shaped and bring urine from the kidneys to the urinary bladder. 3. The urinary bladder is a hollow and muscular organ. It is shaped a little like a balloon. It is the organ that collects urine. 4. Urine leaves the body through the urethra. The kidneys filter the blood that passes through them, and the urinary bladder stores the urine until it is released from the body. Urine is a liquid that is formed by the kidneys when they filter wastes from the blood. Urine contains mostly water, but it also contains salts and nitrogen-containing molecules. The amount of urine released from the body depends on many things. Some of these include the amount of fluid and food a person consumes and how much fluid they have lost from sweating and breathing. Urine ranges from colorless to dark yellow but is usually a pale yellow color. Light yellow urine contains mostly water. The darker the urine, the less water it contains. The urinary system also removes a type of waste called urea from your blood. Urea is a nitrogen-containing molecule that is made when foods containing protein, such as meat, poultry, and certain vegetables, are broken down in the body. Urea and other wastes are carried in the bloodstream to the kidneys, where they are removed and form urine.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}323{"query": "Hepcidin, a 25-amino-acid peptide secreted by the liver, distributed in the plasma and excreted in urine, is a key central regulator of body iron homeostasis. This hormone decreases export of cellular iron by binding to ferroportin, an iron exporter present at the basolateral surface of enterocytes and macrophages (the sites of dietary iron absorption and iron recycling, respectively), inducing its internalization and degradation. Hepcidin contains eight cysteine residues that form four disulfide bridges, which stabilize a hairpin-shaped structure with two beta sheets. We noticed in the sequence of hepcidin a Cys*-X-Cys* motif which can act as a metal binding site able to trap iron and/or copper. We have tested this hypothesis using a pseudopeptidic synthetic bis-disulfide analogue and we have shown that direct metalation of such ligand leads to the formation of a copper(III) complex with the typical N(2)S(2)donor set. This compound crystallizes in the orthorhombic system, space group Imma. The Cu(III) configuration is square planar, built up from two carboximado-N and two thiolato-S donors. This complex is converted back to the bis-disulfide, with release of the copper salt, upon oxidation with iodine.", "pos": "Histone H3 lysine 9 (H3K9) methylation is a major component of gene regulation and chromatin organization. SUV39H1 methylates H3K9 at the pericentric heterochromatin region and participates in the maintenance of genome stability. In this study, a recombinant purified SUV39H1 is used for substrate specificity and steady-state kinetic analysis with peptides representing the un- or dimethylated lysine 9 histone H3 tail or full-length human recombinant H3 (rH3). Recombinant SUV39H1 methylated its substrate via a nonprocessive mechanism. Binding of either peptide or AdoMet first to the enzyme made a catalytically competent binary complex. Product inhibition studies with SUV39H1 showed that S-adenosyl-l-homocysteine is a competitive inhibitor of S-adenosyl-l-methionine and a mixed inhibitor of substrate peptide. Similarly, the methylated peptide was a competitive inhibitor of the unmethylated peptide and a mixed inhibitor of AdoMet, suggesting a random mechanism in a bi-bi reaction for recombinant SUV39H1 in which either substrate can bind to the enzyme first and either product can release first. The turnover numbers (k(cat)) for the H3 tail peptide and rH3 were comparable (12 and 8 h(-)(1), respectively) compared to the value of 1.5 h(-)(1) for an identical dimethylated lysine 9 H3 tail peptide. The Michaelis constant for the methylated peptide (K(m)(pep)) was 13-fold lower compared to that of the unmethylated peptide. The Michaelis constants for AdoMet (K(m)(AdoMet)) were 12 and 6 microM for the unmethylated peptide substrate and rH3, respectively. A reduction in the level of methylation was observed at high concentrations of rH3, implying substrate inhibition. Deletion of the chromodomain or point mutation of the conserved amino acids, W64A or W67A, of SUV39H1 impaired enzyme activity despite the presence of an intact catalytic SET domain. Thus, SUV39H1 utilizes both the chromodomain and the SET domain for catalysis.", "neg": "The ubiquitously expressed iron storage protein ferritin plays a central role in maintaining cellular iron homeostasis. Cytosolic ferritins are composed of heavy (H) and light (L) subunits that co-assemble into a hollow spherical shell with an internal cavity where iron is stored. The ferroxidase activity of the ferritin H chain is critical to store iron in its Fe3+ oxidation state, while the L chain shows iron nucleation properties. We describe a unique case of a 23-yr-old female patient affected by a homozygous loss of function mutation in the L-ferritin gene, idiopathic generalized seizures, and atypical restless leg syndrome (RLS). We show that L chain ferritin is undetectable in primary fibroblasts from the patient, and thus ferritin consists only of H chains. Increased iron incorporation into the FtH homopolymer leads to reduced cellular iron availability, diminished levels of cytosolic catalase, SOD1 protein levels, enhanced ROS production and higher levels of oxidized proteins. Importantly, key phenotypic features observed in fibroblasts are also mirrored in reprogrammed neurons from the patient's fibroblasts. Our results demonstrate for the first time the pathophysiological consequences of L-ferritin deficiency in a human and help to define the concept for a new disease entity hallmarked by idiopathic generalized seizure and atypical RLS.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}324{"query": "The Na(+)/Ca(2+)exchanger (NCX) principal function is taking 1 Ca(2+) out of the cytoplasm and introducing 3 Na(+). The increase of cytoplasmic Na(+) concentration induces the NCX reverse mode (NCX(REV)), favoring Ca(2+) influx. NCX(REV) can be inhibited by: KB-R7943 a non-specific compound that blocks voltage-dependent and store-operated Ca(2+) channels; SEA0400 that appears to be selective for NCX(REV), but difficult to obtain and SN-6, which efficacy has been shown only in cardiomyocytes. We found that PPADS, a P2X receptor antagonist, acts as a NCX(REV) inhibitor in guinea pig tracheal myocytes. In these cells, we characterized the NCX(REV) by substituting NaCl and NaHCO(3) with LiCl, resulting in the increase of the intracellular Ca(2+) concentration ([Ca(2+)]i) using fura 2-AM. We analyzed 5 consecutive responses of the NCX(REV) every 10 min, finding no differences among them. To evaluate the effect of different NCX(REV) blockers, concentration response curves to KB-R7943 (1, 3.2 and 10 M), and SN-6 (3.2, 10 and 30 M) were constructed, whereas PPADS effect was characterized as time- and concentration-dependent (1, 3.2, 10 and 30 M). PPADS had similar potency and efficacy as KB-R7943, whereas SN-6 was the least effective. Furthermore, KCl-induced contraction, sensitive to D600 and nifedipine, was blocked by KB-R7943, but not by PPADS. KCl-induced [Ca(2+)]i increment in myocytes was also significantly decreased by KBR-7943 (10 M). Our results demonstrate that PPADS can be used as a reliable pharmacological tool to inhibit NCX(REV), with the advantage that it is more specific than KB-R7943 because it does not affect L-type Ca(2+) channels.", "pos": "The effects of 2-[4-[(2,5-difluorophenyl) methoxy]phenoxy]-5-ethoxyaniline (SEA0400), a newly synthesized Na(+)-Ca(2+) exchanger (NCX) inhibitor, on the NCX current and other membrane currents were examined in isolated guinea-pig ventricular myocytes and compared with those of 2-[2-[4-(4-nitrobenzyloxy) phenyl]ethyl]isothiourea (KB-R7943). SEA0400 concentration-dependently inhibited the NCX current with a 10 fold higher potency than that of KB-R7943; 1 microM SEA0400 and 10 microM KB-R7943 inhibited the NCX current by more than 80%. KB-R7943, at 10 microM, inhibited the sodium current, L-type calcium current, delayed rectifier potassium current and inwardly rectifying potassium current by more than 50%, but SEA0400 (1 microM) had no significant effect on these currents. These results indicate that SEA0400 is a potent and highly selective inhibitor of NCX, and would be a powerful tool for further studies on the role of NCX in the heart and the therapeutic potential of its inhibition.", "neg": "Differentiation of cancer stem cells (CSCs) into cancer cells causes increased sensitivity to chemotherapeutic agents. Although inhibition of mammalian target of rapamycin (mTOR) leads to CSC survival, the effect of branched chain amino acids (BCAAs), an mTOR complex 1 (mTORC1) activator remains unknown. In this study, we examined the effects of BCAA on hepatocellular carcinoma (HCC) cells expressing a hepatic CSC marker, EpCAM. We examined the effects of BCAA and/or 5-fluorouracil (FU) on expression of EpCAM and other CSC-related markers, as well as cell proliferation in HCC cells and in a xenograft mouse model. We also characterized CSC-related and mTOR signal-related molecule expression and tumorigenicity in HCC cells with knockdown of Rictor or Raptor, or overexpression of constitutively active rheb (caRheb). mTOR signal-related molecule expression was also examined in BCAA-treated HCC cells. In-vitro BCAA reduced the frequency of EpCAM-positive cells and improved sensitivity to the anti-proliferative effect of 5-FU. Combined 5-FU and BCAA provided better antitumor efficacy than 5-FU alone in the xenograft model. Stimulation with high doses of BCAA activated mTORC1. Knockdown and overexpression experiments revealed that inhibition of mTOR complex 2 (mTORC2) or activation of mTORC1 led to decreased EpCAM expression and little or no tumorigenicity. BCAA may enhance the sensitivity to chemotherapy by reducing the population of cscs via the mTOR pathway. This result suggests the utility of BCAA in liver cancer therapy.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}325{"query": "Four Seasons Wines Limited is an Indian winery which was established in 2006,based in Bangalore, India.", "pos": "For each vintage, the CIVC rated the villages of the area based on the quality of their grapes and vineyards. The rating was then used to determine the price and the percentage of the price that growers get. The Grand Cru rated vineyards received 100 percent rating which entitled the grower to 100% of the price. Premier Crus were vineyards with 9099% ratings while Deuxieme Crus received 8089% ratings. Under appellation rules, around 4,000 kilograms (8,800 pounds) of grapes can be pressed (wine) to create up to 673 gallons (US) (either 2,550 L or 3,060 L) of juice. The first 541 gallons (either 2,050 L or 2,460 L) are the cuvee and the next 132 gallons (either 500 L or 600 L) are the taille. Prior to 1992, a second taille of 44 gallons (either 167 L or 200 L) was previously allowed. For vintage Champagne, 100% of the grapes must come from that vintage year while non-vintage wine is a blend of vintages. Vintage champagne must spend a minimum of three years of aging. There are no regulations about how long it must spend on its Lees (fermentation), but some of the premier Champagne houses keep their wines on Lees (fermentation) for upwards of five to ten years. Non-vintage Champagne must spend a minimum of 15 months of aging but only a minimum of 12 months on the lees. Most of the Champagne houses keep their wines on the lees through the whole time of aging because it is more expense to bottle the wine then age it and finally shipped.", "neg": "Armstrong Siddeley was merged with the aircraft engine business of Bristol Aeroplane Company (Bristol Aero Engines) to form Bristol Siddeley as part of an ongoing rationalisation under government influence of the British aircraft and aircraft engine manufacturers.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}326{"query": "Thomas W. Meaux is a former member of the Wisconsin State Assembly.", "pos": "Willard T. Stevens was a member of the Wisconsin State Senate.", "neg": "The Besbre is a river in central France, left tributary of the river Loire.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}327{"query": "It is increasingly clear that the normal protein alpha-synuclein is in some manner closely associated with presynaptic components of select neuronal types within the adult human central nervous system (CNS) and, in addition, that in its pathologically altered state alpha-synuclein aggregates selectively in the form of filamentous inclusion bodies during certain progressive neurodegenerative disorders, such as familial and sporadic Parkinson's disease. By having the antibody AFshp raised specifically to alpha-synuclein to label Parkinson disease-specific Lewy bodies and Lewy neurites as well as synaptic boutons containing the unaltered protein, an initial attempt is made to map the overall distribution pattern and describe the staining behavior of the immunoreactive punctae in select regions of the prosencephalon. Neocortical immunolabeling is most prominent in the prodigious, but incompletely myelinated, association fields and faintest in the heavily myelinated primary motor and primary sensory fields, with the premotor and first order sensory association areas occupying an intermediate position. Of the thalamic grays evaluated, those containing powerfully myelinated fiber tracts (e.g. centrum medianum, habenular complex) show the weakest immunolabeling, whereas, less sturdily myelinated structures are highly immunoreactive. The fact that the immunostaining spectrum for normal alpha-synuclein is so broad, together with the fact that some thalamic sites actually are immunonegative leads to the following conclusions (1) alpha-synuclein, although present in the synaptic boutons of many nerve cells in the adult human CNS, is by no means ubiquitous there, and (2) neuronal types lacking the normal protein cannot generate the Parkinson's disease-specific filamentous pathology.", "pos": "alpha-Synuclein is a presynaptic protein recently identified as a specific component of Lewy bodies (LB) and Lewy neurites. The aim of this study was to assess the morphology and distribution of alpha-synuclein immunoreactivity in cases of dementia with LB (DLB), and to compare alpha-synuclein with ubiquitin immunostaining. We examined substantia nigra, paralimbic regions (entorhinal cortex, cingulate gyrus, insula and hippocampus), and neocortex (frontal and occipital association cortices) with double alpha-synuclein and ubiquitin immunostaining in 25 cases meeting neuropathological criteria for DLB. alpha-Synuclein immunostaining was more specific than ubiquitin immunostaining in that it differentiated LB from globose tangles. It was also slightly more sensitive, staining 4-5% more intracytoplasmic structures, especially diffuse alpha-synuclein deposits that were ubiquitin negative. In addition to LB, alpha-synuclein staining showed filiform and globose neurites in the substantia nigra, CA2-3 regions of the hippocampus, and entorhinal cortex. A spectrum of alpha-synuclein staining was seen in substantia nigra: from diffuse \"cloud-like\" inclusions to aggregated intracytoplasmic inclusions with variable ubiquitin staining to classic LB. We hypothesize that these represent different stages in LB formation.", "neg": "To investigate the clinicopathologic features of focal cortical dysplasia (FCD) in patients with refractory epilepsy. The clinical, radiologic and pathologic features of 38 cases of FCD receiving surgical treatment in 2005 were reviewed retrospectively. The mean age of disease onset was 9.2 years. The disease lasted for 11.9 years on average and often presented as complex partial seizure. Radiologic examination revealed hippocampal sclerosis, or abnormal signals in the grey matter in 21 cases. According to Palmini's classification system, the following pathologic subgroups were identified: FCD type IA (3/38), FCD type IB (20/38), FCD type IIA (5/38) and FCD type IIB (5/38). The remaining 5 cases were classified as mild cortical dysplasia. Topographically, FCD type II was often seen in the extratemporal region (8/10), predominantly in the frontal lobe (5/8). Dual pathology was identified only in cases with FCD type IB. Immunohistochemical study showed that the giant neurons, immature neurons and dysmorphic neurons were strongly positive for NeuN. A small number of balloon cells expressed nestin. FCD is a common cause of refractory epilepsy. FCD type IB is the predominant pathologic subtype. Associated hippocampal sclerosis is sometimes seen. Clinicopathologic differences between FCD type I and FCD type II are observed.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}328{"query": "Hit-Girl (real name Mindy McCready) is a fictional character appearing in the Kick-Ass series, published by Marvel Comics under the company's imprint Icon Comics.", "pos": "Margaret Power is a fictional character in the Marvel Universe.", "neg": "The figure of a limp woman with long curly hair is seen drifting underwater, and a voiceover questions the end of a life that never truly existed. This life ended in murder, the victim herself unsure of who her killer was and why she was killed. Her death was only metaphorical, for in her place a new life begins.The story starts with Patience Phillips (Halle Berry), a timid woman who can't stand up for herself. She lets people walk all over her, and has wasted her artistic talent working for a cosmetic company as a graphic designer. George Hedare (Lambert Wilson) runs the company with his supermodel wife, Laurel (Sharon Stone). Laurel knows that Patience is capable, but seems mostly indifferent, only using her in own power struggles with her husband. George, an abusive boss in general, finds plenty of opportunity to mock Laurel.The company is about to launch BeauLine, a new anti-aging product that Laurel had secretly been using for years. The advertisement is designed by Patience but George, unsatisfied, demands that she redesigns it. Upset and frustrated, Patience returns home and sees a cat looking up at her. Shaking her head, she goes to sleep, but her loud neighbours keeps her up and she is unable to rest. Next morning, the cat is on her window ledge. When she approaches, she realizes the cat has climbed up to a higher ledge and was potentially stuck. To try and reach the cat, Patience climbs out her window ledge, and a passing detective mistakens her intentions as suicidal. He ends up rushing into her apartment and pulling her back in. Patience would have thanked him but realizes she is late for work, in her hurry to leave she drops her wallet. The detective, Tom Lone (Benjamin Bratt), tracks her down to her workplace and returns it to her, and both agree to a coffee date.Later that night, Patience goes to the production factory to deliver her artwork, and she accidentally hears that the BeauLine has unsafe health problems. Stunned, she backs into several tools, revealling her presence. Two men chase her into a large waste water pipe, where she is trapped, and they flush her into the river, where she drowns. The cat that has been appearing in front of Patience appears by her body and gathers several other cats around her.Patience eventually drags herself unsteadily up and returns home. Her movements are off and uncontrollable, and she ends up breaking the glass through her own window. When her neighbours start their usual loud party again, she yells at them to quiet but they again ignore her. The old Patience would have backed down, but now she strodes down, knocks on their door, and promptly beats up the host and destroys the music equipment in front of many shocked guests. When she wakes up the next morning, she almost dismisses everything as a dream until she sees the broken glass. Unfortunately, her memories of what happened before that are blank, and so she cluelessly returns back to work.At work, George loudly yells at Patience in front of all her coworkers for not handling in her project. She tunes him out, which angers him further, and when she apologizes he only continues. Patience than apologizes for wasting her time in the company, and is fired, but as soon as George leaves her colleagues swarm around her in congratulations. Patience packs up her things and while she and her friends are walking home, two dogs instantly begin barking at her and she instinctively hisses at them. When questioned, she explains her behaviour as allergies. When they pass by a jewelry store, Patience's attention is caught by a beautiful collar-like necklace, but is reminded of her new unemployed status and leaves longingly. Once home, she sees the same cat again, and finally close enough she was able to find the address on the cat's owner.The cat belonged to an older woman named Ophelia, a former professor who lived alone in a house full of cats. She explains that the cat constantly appearing in front of Patience is named Midnight, a rare Egyptian", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}329{"query": "The Seattle Seahawks kicked off their 2013 campaign with a hard-fought, ugly win over the Carolina Panthers, 12-7. This game marked Russell Wilson's first 300-yard passing game, and Cam Newton's worst career performance, posting 125 yards through the air, a career low. The first quarter ended equal for both teams, as both sides exchanged a couple of punts. Seattle took their third drive of the game in the second quarter, and drove into the red zone, capping it with a Steven Hauschka 27-yard field goal. Carolina responded immediately, and taking advantage of a couple of Seattle penalties, and some big runs by DeAngelo Williams, with Cam Newton hitting Steve Smith for a 3-yard TD. Seattle responded with a drive to around the Carolina 27 yard line, but Charles Godfrey sacked Russell Wilson and stripped the football, which Carolina recovered. So the first half ended 7-3, Carolina. The second half began with a defensive battle between both sides. Seattle then broke the deadlock with a Steven Hauschka 40-yard field goal, on a drive that lasted over 4 minutes, cutting the lead to 7-6. After forcing Carolina to punt midway through the fourth quarter, Seattle's offense produced its finest drive of the day. A couple of Russell Wilson passes, followed by a Robert Turbin 15-yard scamper, set up Seattle at the Panthers' 43 yard line. Russell Wilson overthrew receiver Stephen Williams on first down, but on second down and 10, by using exactly the same play, Wilson connected with second-year man Jermaine Kearse for a 43-yard score, with 10 minutes left to play. They failed the two-point conversion however, so Seattle had a 12-7 lead. Carolina responded by using DeAngelo Williams on some big runs. Inside the Seattle 35 yard line, Williams took off for a 24-yard scamper, and looked like he was going to score, however at the last possible moment, Earl Thomas forced Williams to fumble inside the 10 yard line.", "pos": "Marino finished the game with 29 out of 50 pass completions for 318 yards, 1 touchdown, and 2 interceptions. Clayton was the top receiver of the game, with 6 receptions for 92 yards. Walker returned 4 kickoffs for 93 yards and gained 15 yards on 2 punt returns. Nathan was the Dolphins leading rusher with 18 yards, while also catching 10 passes for 83 yards. Craig had 58 rushing yards, 77 receiving yards, and 3 touchdowns. He was the first player ever to score 3 touchdowns in a Super Bowl, and his 2 touchdown catches also tied a Super Bowl record. Tyler led San Francisco in rushing with 65 yards, and also caught 4 passes for 70 yards. Clark caught 6 passes for 77 yards. Board recorded 2 sacks. McLemore recorded 51 punt return yards, the second most in Super Bowl history. Sports Illustrated called 49ers defensive tackle Gary Johnson (American football) the Super Bowls \"unofficial defensive MVP\" after he recorded one sack, flushed Marino out of the passing pocket numerous times, and had four unassisted tackles.", "neg": "This game is well known for an infamous penalty that occurred during the overtime period. The Jets were lining up for a game winning 56-yard field goal in overtime to try and give them the win. Nick folk kicked the ball, but the kick went wide right and the Patriots appeared to be taking over with a chance to win. However, Chris Jones of New England was called for a controversial unsportsmanlike conduct penalty after pushing his teammate into the offensive line. This penalty would later be named \"leaping\". The penalty gave the Jets another chance and made the field goal attempt a 51-yard attempt. This time, Folk drilled the kick, and the Jets would go on to stun the Patriots. With the win, the Jets improved to 4-3.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}330{"query": "Sibton Abbey, an early Cistercian abbey located near Yoxford, Suffolk, was founded about 1150 by William de Chesney, High Sheriff of Norfolk and Suffolk.", "pos": "Bonne-Esperance Abbey was a Premonstratensian abbey that existed from 1130 to the end of the 18th century, located in Vellereille-les-Brayeux in the Walloon municipality of Estinnes, province of Hainaut, Diocese of Tournai, in present-day Belgium.", "neg": "Carl Michael Bellman was born on 4 February 1740 in the Stora Daurerska house, which was one of the finest in the Sodermalm district of Stockholm.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}331{"query": "Jack Elgin is the European editor of The Economist, which is based in London, England. Jack has a wife named Maria and three kids named Joanne, Julia, and Andrew. Jack subtly changes the family vacation from a lazy week of Mediterranean fun and sun in Corfu, Greece, to a tour of India, because of a story he has to cover. Maria is not as impressed by this as the kids are. Jack himself envisioned a chance to simultaneously work an easy reporting assignment and spend a little quality time with his family. But on the way to India, the airplane, a 747 owned by AM Air, an American airline, makes an unscheduled stopover in Limassol Cyprus, because of a mechanical problem. After a while of waiting inside the Limassol airport, everyone gets back on the plane -- which is then hijacked by a group of terrorists known as the August 15th Movement, led by a Serbian man named Ivanic Loyvek and his right-hand man Karadan Maldic. The terrorists take a silver briefcase from an diplomatic courier, an older man, and it appears to be an important object of their hijack. And they are demanding $50,000,000 from the US State Department in one hour, or everyone on the airplane will die.The demand is met, and Loyvek and Maldic start releasing the women and children, with the men to go last. But as soon as a front passenger door is opened, the local police begins shooting. Inside the plane, the owner of the briefcase retrieves it, only to be killed the terrorists, who take it again.The flight attendants frantically open the rest of the airplane's doors and start getting passengers out, but the terrorists start killing passengers, leading to an explosion. Maria, Joanne, and Julia get out of the airplane, and then Jack, holding Andrew, gets out -- only to watch Maria, Joanne, and Julia get shot by the terrorists. Jack tries to hide Andrew's face so he can't see. Maria and Joanne are killed, but Julia burns to death while crying for help.Jack and Andrew survive. 15 passengers die, and Loyvek and Maldic, the surviving terrorists, escape, knowing that they now have the $50,000,000. Back in London, a devastated Jack is told that the terrorists were captured, but they were released and deported secretly, with no charges and no arrest, the result of some awfully compromised politics. Jack is understandably enraged that Loyvek and Maldic got off scot-free. While helping Andrew cope, Jack tries all the legal ways to ensure justice for his family, but to no avail.Jack even pays a visit to Henry Davidson, a CIA agent who works at the American Embassy in London. Davidson tells Jack that there's little that can be done. The American and British governments are completely impotent when it comes to going after Loyvek and Maldic. Jack decides he has no choice in the matter but to seek revenge. With the help of his ex-intelligence operative friend Kate Stockton, who is well-schooled in the finer points of international intelligence, Jack becomes a one-man anti-terrorist squadron, searching for Loyvek and Maldich. He finds a warehouse they apparently are using as a headquarters. Breaking in, he finds some papers which he takes, and some weapons. The terrorists return, find a flashlight Jack was using, and begin searching the warehouse. Jack returns upstairs, retrieves a machine pistol and loads it with a magazine. He kills three terrorists before escaping.He later breaks into the home of a friend at MI6 and steals a Walther PPK pistol from his home. He shows up at a theatre and makes a scene at the bar, to be sure he is noticed by the bartender. He then follows one of the terrorists in his taxicab, killing him with that weapon. He returns to the theatre and makes a point of apologizing to the bartender. The next day he goes pheasant hunting with his MI6 contact in case he is tested for gunpowder residue.Dogging Jack's trail is FBI agent Jules Bernard, who's cooperating with Scotland Yard on anti-terrorist activities, and who suspects", "pos": "A volcanic eruption in Iceland has sent ash across northern Europe. Airlines have stopped or changed the flights across the Atlantic Ocean, leaving hundreds of passengers stuck in airports. Grimsvotn is one of the largest and most active volcanoes in Europe. What makes Grimsvotn different is that it lies under a huge glacier of ice up to 12 metres thick. The hot volcano heats up the ice above it, which then forms a layer of water between glacier and the volcano, keeping it stable. As the water flows out from under the glacier, the pressure lifts. The lava from the volcano then comes up to the surface. This is exactly what is happening today. Now airlines have to make changes to their flights so as not to fly through the clouds of volcanic ash. According to KLM, one of Europe's biggest airlines, airplanes cannot go under the cloud or over it. Going through the cloud can result in ash getting stuck in the airplane's engines, causing damage to the plane. The eruption has also caused problems for animals in Iceland. The volcano left ash and sharp, glass-like rocks all over the countryside. Farmers are keeping their animals inside to stop them eating ash-covered grass or the sharp objects.", "neg": "Simon Miller (Loren Dean) outwardly appears to be a geologist who must frequently take business trips, which has strained the relationship with his family, including his wife Meredith (Robyn Lively) and teenage children Sarah (Skyler Day) and Kevin (Drew Koles). When Simon suddenly goes missing, his family searches his office and discovers several passports, each with different aliases. They soon learn that Simon was in fact a spy who kept his true career secret from them. Simon mysteriously calls home and warns his family not to tell anyone about his disappearances, then abruptly hangs up. His family begins a search for Simon, which takes them to locations around the world. Sarah, an honor student, uses her foreign language skills to help, and Kevin uses his knowledge of technology.[1] They receive assistance from Amanda (Christine Baranski), another covert operative who initially appears to be a friend, but appears to have her own motives.[2]", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}332{"query": "Nevow (pronounced like the French nouveau) is a Python web application framework originally developed by the company Divmod.", "pos": "NeXTSTEP (also stylized as NeXTstep, NeXTStep, and NEXTSTEP) is a combination of several parts: a Unix operating system based on the Mach kernel, plus source code from BSD Display PostScript and a proprietary windowing engine the Objective-C language and runtime an object-oriented (OO) application layer, including several ''kits'' development tools for the OO layers NeXTSTEP is notable for having been a preeminent implementation of the latter three items.", "neg": "Cerruti 1881 is a brand of the fashion house Cerruti founded in 1967 in Paris by the Italian stylist and fashion producer Nino Cerruti.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}333{"query": "Succession is now regulated by laws passed by the National Diet. The current law excludes women from the succession. A change to this law had been considered until Princess Kiko gave birth to a son. Until the birth of Prince Hisahito, son of Prince Akishino, on September 6, 2006, there was a potential succession problem, since Prince Akishino was the only male child to be born into the imperial family since 1965. Following the birth of Princess Aiko, there was public debate about amending the current Imperial Household Law to allow women to succeed to the throne. In January 2005, Prime Minister Junichiro Koizumi appointed a special panel composed of judges, university professors, and civil servants to study changes to the Imperial Household Law and to make recommendations to the government. The panel dealing with the succession issue recommended on October 25, 2005, amending the law to allow females of the male line of imperial descent to ascend the Japanese throne. On January 20, 2006, Prime Minister Junichiro Koizumi devoted part of his annual keynote speech to the controversy, pledging to submit a bill allowing women to ascend the throne to ensure that the succession continues in the future in a stable manner. Shortly after the announcement that Princess Kiko was pregnant with her third child, Koizumi suspended such plans. Her son, Prince Hisahito, is the third in line to the throne under the current law of succession. On January 3, 2007, Prime Minister Shinzo Abe announced that he would drop the proposal to alter the Imperial Household Law.", "pos": "Potone (Greek: Potone or Potone; born before 427 BC) daughter of Ariston and Perictione, was Plato's older sister.", "neg": "Spanish men will have to learn to change diapers and do dishwashing under the terms of a new law designed to strike a blow. The law, due to be passed this month, is likely to cause a revolution in family affairs in a country where 40% of men reportedly don't do housework at all. It will oblige men to \"share domestic responsibilities and the care and attention\" of children and elderly family members, according to the draft approved by the Spanish parliament's justice commission. \"This will be a good way of reminding people what their duties are. It is something feminists have been wanting for a long time,\" said Margarita Uria, of the Basque Nationalist Party, who was behind what is an amendment to a new divorce law. Failure to meet the obligations will be taken into consideration by judges when determining the terms of divorces. Men who refuse to do their part may be given less frequent contact with their children. Spanish women spend five times longer on housework than husbands. Even when both have jobs outside the home, Spanish women still do three times as much work in the house. \"It is not just about housework, though,\" said Ms. Uria. A study five years ago by Spain's Center for Sociological Investigation concluded that fathers spent an average of 13 minutes each day looking after their children. Only 19 % of Spanish men thought it was right for mothers of school-age children to have a full-time job. More than a third thought mothers should not work outside the home at all. The Change to the Spanish legal code will see domestic obligations added to a list of marital duties that currently includes fidelity, living together and helping one another. That should guarantee that, when the law--which will also make divorce proceedings faster and easier--is voted on in parliament in the next few weeks, the obligation to share domestic chores will be added to the statute books.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}334{"query": "Paris, 1966...Monsieur Charles Bonnet (Hugh Griffin), the current head of the Bonnet family, custodian of the family's legendary collection of fine art, and a noted collector in his own right, is offering one of his prized paintings at auction. A Cezanne, it sells for a fabulous $515,000, the high point of the auction. When Bonnet's daughter, Nicole (Audrey Hepburn), hears the news on her car radio on her way home from work, she is shocked...and dismayed. The moment she arrives at their elegant old chateau, she runs upstairs calling her father. In his bedroom on the second floor, she opens the door to an antique wardrobe and steps inside, opens a false panel at the back of the wardrobe and climbs a hidden spiral staircase to her father's secret studio in the attic.Bonnet, it turns out, is a forger of fine art...cheerful and charming, but an unrepentant scoundrel. He is putting the finishing touches on his latest project, a flawless rendition of a famous lost Van Gogh. He has even found another painting from the same period, by an unknown artist, and has brushed dirt from the back of that canvas to transfer to his forgery. \"I doubt if even Van Gogh himself would have gone to such pains with his work,\" he boasts. \"He didn't have to, Papa,\" Nicole retorts, \"he WAS Van Gogh!\" She tells him in a tired voice (for what must surely be the thousandth time) that it's a crime to sell fake masterpieces. He replies that he only sells them to wealthy, private buyers, who get an undeniably fine painting in return.A noise in the driveway sends them both to the window: An armored car, a police van, a black limousine and half a dozen motorcycles have arrived and parked in front of the house. Nicole is terrified that the authorities have at last discovered Bonnet's hobby, but Bonnet explains that he has simply agreed to let the Claver-Lafayette Museum display their exquisite statuette of Venus, purportedly carved by 16th Century sculptor Benvenuto Cellini, in their latest exhibit. Nicole is not reassured: Their Cellini Venus is also a forgery...carved at the end of the 19th century by Bonnet's father, using Bonnet's mother as a model. Unlike paintings, she tells her father, it's an easy matter to detect forged sculptures. Bonnet brushes aside her concerns: since he's merely lending the statue, not selling it, there will be no reason to test its authenticity.He runs downstairs (followed closely by Nicole) to greet Monsieur Grammont (Ferdinand Gravey), the museum director, who is here with his assistants and an armed escort to transport the Venus. Bonnet shows him into the library, where the Venus stands in solitary splendor in its own special niche. Grammont is moved almost to tears by the sight of it...he congratulates Bonnet for keeping this fine piece in France, though he must have had many lucrative offers to buy it. Bonnet smiles modestly, and says, \"Well, after all, one is still a Frenchman.\" The Venus is handed over, secured in a heavily padded case, Grammont thanks Bonnet effusively and leaves. Bonnet is jubilant, but Nicole is still worried. He waves off her concern, saying that her basic trouble is that she's honest....\"but I don't tell you that to hurt your feelings,\" he adds kindly. \"I get dizzy spells when we have these conversations, Papa,\" she complains. He invites her to attend the gala opening at the museum that night...she firmly declines.The Cellini Venus is the star of the exhibit, and Bonnet the most celebrated guest at the gala. Davis Leland (Eli Wallach), a wealthy American industrialist, is also present. He has recently taken up art collecting, and is pursuing it as obssessively as he pursued the acquisition of his millions. He is so taken with the Venus that he determines to find out all about Bonnet and his family...with the goal of somehow acquiring the Venus.The Bonnet chateau", "pos": "Ever since the death of their teenage daughter Emily, Doug (James Gandolfini) and Lois (Melissa Leo) Riley have been drifting apart. Because of her grief, Lois has become a cold and distant agoraphobic. Doug begins an affair with Vivian, a younger local waitress. However, Lois manages to maintain her appearance and the presentation of her home despite never leaving and inviting no guests aside from her sister, Harriet. She has even already had headstones put next to their daughter's for them both and made funeral plans. One morning, Doug is informed that Vivian has died, and he travels to New Orleans on a business trip to clear his head. Instead, however, he ends up in a strip club where he meets 16-year-old stripper, Mallory (Kristen Stewart). He politely turns down her offer for a private dance and refuses any sexual contact, but instead accompanies her home and makes an unusual proposition: if Mallory will allow him to stay in her run-down house long enough to straighten himself out, he will pay her $100 a day for her trouble. For Mallory, who isn't used to getting money for doing nothing, it seems like a great deal. She accepts and Doug phones home to tell Lois he won't be coming home for a while. She tells him that she knew about his affair with Vivian but before the conversation can go any further, she hangs up. As time passes, Doug and Mallory settle into an unconventional kind of domesticity, and he becomes more of a father figure for her than anything else including teaching her how to make a bed properly and taking care of her money. Meanwhile, back home, Lois realizes that she'll have to act fast in order to save her marriage, even if that means venturing outside for the first time in nearly a decade. After a couple of attempts, Lois manages to start up her car and get on the freeway heading south. One night, Doug gets a call from Mallory who is in trouble after being robbed of the money she carries around by a client. He goes to pick her up and after arguing about how stupid she's being, he makes her realise that she needs to make some changes before things get worse. The following morning, Lois arrives in town and calls Doug to let him know, who is stunned that she not only left the house but drove all the way instead of flying. He immediately goes to meet her and they embrace one another for the first time in years. On the drive back, he tells her about Mallory (whose real name is Alison) and what she does for a living, which Lois instantly disapproves of. She is shocked to learn how young and foul-mouthed Mallory is. However, like Doug, Lois quickly warms to her due to her striking similarities to Emily. Before long, Lois has also moved in to Mallory's home and the three start to form an unconventional family. Lois helps her out with female problems and takes her shopping to buy suitable underwear, making her feel like a mother again, which she enjoys dearly. But later on when Lois attempts to steer Mallory from the path of self-destruction, the young girl flees. Mallory is then later arrested an altercation with a client, and Doug and Lois rush to be by her side, but shortly after they bail her out, she runs again. In that moment, Doug and Lois realize they cannot use Mallory as a substitute for their daughter and return home to Indianapolis. A few days later, Doug receives a phone call from Mallory in Houston. She looks cleaned up and healthier, and announces her plans about moving to Las Vegas, just before boarding the bus. Doug tells her that he and Lois will always be there for her.", "neg": "In 1959, Michael Courtland (Robertson), a New Orleans real estate developer, has his life shattered when his wife Elizabeth (Bujold) and young daughter Amy are kidnapped. The police recommend that he provide the kidnappers with a briefcase of shredded blank paper instead of the demanded ransom, as the kidnappers will then be more likely to surrender when cornered, rather than attempt to escape with cash in hand. Courtland agrees to this plan. This leads to a bungled car chase in which both kidnappers and victims are killed in a spectacular explosion. Courtland blames himself for the deaths of his wife and daughter. Fifteen years pass. Courtland is morbidly obsessed with his dead wife, and regularly visits a monument he has had built in her memory. The monument is a replica of the church (Basilica di San Miniato al Monte) where he and Elizabeth had met many years before in Florence, Italy. His real estate partner Robert LaSalle (Lithgow) convinces Courtland to tag along on a business trip back to Florence. While there, Courtland revisits the church, and suddenly comes face to face with a young woman named Sandra (Bujold) who looks exactly like his late wife. The already slightly unhinged Courtland begins to court the young woman, and subtly attempts to transform her into a perfect mirror image of his dead wife. Courtland returns to New Orleans with Sandra so they can marry. On their wedding night, Sandra is kidnapped and a ransom note is left behind by her abductors. It is an exact replica of the kidnappers' message from fifteen years before. This time, Courtland decides to deliver the demanded cash. He withdraws massive quantities of money from his accounts and business holdings, financially ruining him and forcing him to sign over his interest in the real estate business to LaSalle. In the process, he discovers that his entire ordeal, including the original kidnapping, had been engineered by LaSalle as a way to gain sole control of Courtland's company share holdings. The now nearly insane Courtland stabs LaSalle to death. Knowing that Sandra must have been a willing accomplice in the plot against him, he goes to the airport to kill the escaping woman. On the plane, Sandra has a flashback to her part in the scheme; she is in fact Courtland's daughter: following the original kidnapping LaSalle concealed her survival and sent her to live in secret with an Italian caretaker. Over the years, LaSalle has told her lies about Courtland, convincing her that her father had not paid the ransom because he didn't love her. Sandra, who has come to love Courtland, attempts suicide on the plane and is taken off the flight in a wheelchair. Courtland sees her and runs toward her, gun drawn. A security guard attempts to stop him but Courtland smashes the briefcase full of money against the guard's head, knocking him unconscious. The briefcase breaks open and all of the money flies out. Sandra, seeing the fluttering bills, stands up and shouts: \"Daddy! You brought the money!\" Courtland now realizes for the first time who Sandra really is, and father and daughter fall into a deep embrace.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}335{"query": "To Whom It May Concern, My husband Jim and I got married in 1965. For the first ten years of our marriage, I was very happy to stay home and raise our three children. Then about four years ago, our youngest child went to school, and I thought I might go back to work. Jim was very supportive and helped me to make my decision. He started to do all the things I used to do around the house, and said he thought I could be a great success in business. After several weeks of job hunting, I found my present job, which is working for a small public relation firm. At first, my husband was proud of me and would tell his friends, \"My clever little wife can run that company she's working for.\" But, as his joking words were becoming reality, Jim stopped talking to me about my job. I have received several promotions and pay increases, and I am now making more money than he is. I can buy my own clothes and a new car. Because of our combined incomes, Jim can do things that we had always dreamed of doing, but we don't do these things because he is unhappy. We fought about little things, and Jim is very critical of me in front of our friends. For the first time in our marriage, I think there is a possibility that our marriage may come to an end. I love Jim very much, and I don't want him to feel inferior , but I also love my job. I think I can be a good wife and a working woman, but I don't know how. Can you give me some advice? Will I have to choose one or the other or can I keep both my husband and my new career? Please help. Yours, Mary", "pos": "Dear Daisy, Phew! I'm so glad that day is over. I was so worried all summer that my first day at my new school would be terrible. I'm really tired, but my first day at school went well and I feel much better now. First of all, we had to meet outside the school building. I was very nervous because my primary school only had 300 pupils but in the secondary school there are about 1,300. What a difference! The older pupils are really big. I felt so small waiting there in front of the school. The other problem was that I didn't know anyone. My family moved over the summer holidays, because of Dad's new job. So now I have to try to make some new friends. Standing in front of the school this morning, I wanted to be back at my old school with my old friends. The head teacher came out and told us to go into the school hall. Then he called our names out to tell us which class we were in. My class teacher is called Mrs. Black. She took us to our classroom. It's on the 5th floor and ... guess what? ... We aren't allowed to use the lift. I couldn't believe it. When we were walking up all the stairs I started talking to another boy who didn't know anyone. He said his family had moved from Hong Kong over the summer. He seemed really nice so we sat together when we got to our classroom, out of breath! He said his English was very poor but I thought it was really good. We spent all morning with Mrs. Black looking at our timetables. Everyone in the school has a different timetable--can you believe it? Half of the school is learning Spanish as a second language and the other half learns French. I'm in the Spanish group, which sounds like fun. I'm worried that I'll forget my timetable and go to the wrong room! How will anyone help me if nobody else has the same timetable as me? Lunchtime was OK. After lunch we started lessons. I had maths, which was complicated and difficult and then history, where we started to learn about ancient Greece. That looks interesting. I have to do some homework tonight to find out how the ancient Greek people lived. So far so good. I'm quite looking forward to tomorrow, even though I've got science. I hate science! Jason", "neg": "In this life, what did you miss? The wife asked the husband when she was 25. Despondently, the husband replied: 'I missed a new job opportunity.' When she was 35, the husband angrily told her that he had just missed the bus. At 45, the husband sadly said: 'I missed the opportunity seeing my closed relative before his last breath.' At 55, the husband said disappointingly: 'I missed a good chance to retire.' At 65, the husband hurriedly replied: 'I missed a dental appointment.' At 75, the wife did not ask the husband anymore, the husband was kneeling in front of the very sick wife. Remembering the question the wife used to ask him, this time he asked the wife the same question. The wife, with a smile and peaceful look, replied: 'In this life, I did not miss having you!' The husband was full of tears. He always thought that they could be together forever. He was always busy with work and trifles. So much so he had never been thoughtful to his wife. The husband hugged the wife tightly and said: 'Over 50 years, how I had allowed myself to miss your deep love for me.' In the busy city life, there are many people who are always busy with work. These people revolve their lives around their jobs, these people sacrifice all their times and health to meet the social expectations. They are unwilling to spend times on health care. They miss the opportunity to be with their children in their growing up. They neglect the loved ones who care for them, and also their health. Nobody knows what is going to happen one year from now. Life is not _ , so always live in the now. Express your gratitude to your loved ones in words. Show your care with actions. Treat everyday as the last episode of life. In this way, when you are gone, you loved ones would have nothing to feel sorry about.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}336{"query": "NGC 4030 is a grand design spiral galaxy located about 64 million light years away in the constellation Virgo.", "pos": "The Veil Nebula is a cloud of heated and ionized gas and dust in the constellation Cygnus.", "neg": "The Draco Dwarf is a spheroidal galaxy which was discovered by Albert George Wilson of Lowell Observatory in 1954 on photographic plates of the National Geographic Society's Palomar Observatory Sky Survey (POSS).", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}337{"query": "Hermann Friedrich Kohlbrugge, or Kohlbrugge (August 15, 1803, Amsterdam - March 5, 1875, Elberfeld) was a Dutch (German father) minister.", "pos": "Adolfo Hohenstein (Saint Petersburg, 18 March 1854 -- Bonn, 12 April 1928) was a German painter, advertiser, illustrator, set designer and costume designer.", "neg": "Prince Azim-ush-Shan (December 15, 1664 -- March 18, 1712) was the second son of Mughal emperor Bahadur Shah I, by his second wife, Maharajkumari Amrita Bai Sahiba.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}338{"query": "It seems that great artists and scientists often suffer from mental problems. Both Einstein and Dickens had mental illness. Now scientists have started to look at whether mental illness and genius are linked . Dr. Adele Juda studied 5,000 creative people in Germany. She found there were more people with mental illness in this group than in the general population. Poets had the highest rate of mental illness, followed by musicians, with lower numbers for painters and architects. Other scientists did research which also showed a strong link between mental problems and creativity. But, it did nothing to explain it. Dr. Ruth Richards of Harvard University _ . Instead of studying creative people, she took a group of psychiatric patients and tested them for creativity. The patients got much higher scores than a normal group. Also, the patients' close relatives were much more creative than the patients and a normal group. This suggests that the key to the link between creativity and mental illness is in our genes . But this is a problem. According to Darwinism, harmful genes should be removed. Some scientists believe that evolution has created a balance, where the madness of a few people leads to the development of the whole human race. Geniuses may be mad, bad or just difficult to understand, but their discoveries have improved the world we live in. It seems that a little creative madness is good for us all.", "pos": "Our clothes are a powerful tool that can make us feel better about ourselves. One way in which this works is by wearing different color1s of clothes. Normally when we are sad, we will wear dark color1ed clothes. Oppositely, when we are happy, we often choose to wear brightly color1ed clothes. The reason for this is that our choice of color1 mirrors is how we are feeling. Those who don't believe in the idea are often heard saying, \"if only this truly worked\". Well in reply to those people, there has been a lot of research into what happens to someone's feelings when they are asked to wear just one color1 of clothes. It has been proven that if we wear particular color1s of clothes they can change our feelings. Suppose we are feeling sad, if we wear black we may begin to feel worse. However, if we wear green, red or yellow, we may begin to feel better. Each color1 is said to have its own healing power. So remember, if you are not feeling your best, you can always try out some different color1ed clothes. If one color1 has no effect on your feelings, maybe another will.", "neg": "Mutations of the alpha-synuclein gene have shown to be relevant in some rare families with autosomal dominant Parkinson's disease (PD). Furthermore, alpha-synuclein protein is a major component of the Lewy bodies also in sporadic PD patients. Increased levels of wildtype alpha-synuclein in the cell leads to increased intracellular hydrogen peroxide levels and causes death of dopaminergic neurons in rat primary culture. Subsequently, oxidative stress has been directly linked with alpha-synuclein aggregation in vitro. This raises the question whether increased alpha-synuclein expression might be linked to higher susceptibility to PD and whether alpha-synuclein promoter polymorphisms are associated with PD. Here, two polymorphisms (-116C>G and -668T>C) of the alpha-synuclein promoter defining four haplotypes have been characterized in 315 German PD patients. The influence of the four haplotypes on gene expression was studied by CAT reporter gene assays in neuronal SK-N-AS cells. The -668C/-116G haplotype revealed significant higher CAT expression than the -668T/-116G or the -668T/-116C haplotype, respectively. Although the -668C/-116G haplotype was more common in PD patients, this difference was not significant.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}339{"query": "Protists are placed in the Protist Kingdom. This kingdom is one of four kingdoms in the Eukarya domain. The other three Eukarya kingdoms are the Fungi, Plant, and Animal Kingdoms. The Protist Kingdom is hard to define. It includes many different types of organisms. You can see some examples of protists in Figure 9.1. The Protist Kingdom includes all eukaryotes that dont fit into one of the other three eukaryote kingdoms. For that reason, its sometimes called the trash can kingdom. The number of species in the Protist Kingdom is unknown. It could range from as few as 60,000 to as many as 200,000 species. For a beautiful introduction to the amazing world of protists, watch this video: MEDIA Click image to the left or use the URL below. URL: Scientists think that protists are the oldest eukaryotes. If so, they must have evolved from prokaryotes. How did this happen? How did cells without organelles acquire them? What was the origin of mitochondria, chloroplasts, and other organelles? The most likely way organelles evolved is shown in Figure 9.2. First, smaller prokaryotic cells invaded, or were engulfed by, larger prokaryotic cells. The smaller cells benefited by getting nutrients and a safe place to live. The larger cells benefited by getting some of the organic molecules or energy released by the smaller cells. Eventually, the smaller cells evolved into organelles in the larger cells. After that, neither could live without the other. Despite the diversity of protists, they do share some traits. The cells of all protists have a nucleus. They also have other membrane-bound organelles. For example, all of them have mitochondria, and some of them have chloroplasts. Most protists consist of a single cell. Some are multicellular but they lack specialized cells. Most protists live in wet places. They are found in oceans, lakes, swamps, or damp soils. Many protists can move. Most protists also have a complex life cycle. The life cycle of an organism is the cycle of phases it goes through until it returns to the starting phase. The protist life cycle includes both sexual and asexual reproduction. Why reproduce both ways? Each way has benefits. Asexual reproduction is fast. It allows rapid population growth when conditions are stable. Sexual reproduction increases genetic variation. This helps ensure that some organisms will survive if conditions change. Protists are classified based on traits they share with other eukaryotes. There are animal-like, plant-like, and fungus- like protists. The three groups differ mainly in how they get carbon and energy. Animal-like protists are called protozoa (protozoan, singular). Most protozoa consist of a single cell. Protozoa are probably ancestors of animals. Protozoa are like animals in two ways: 1. Protozoa are heterotrophs. Heterotrophs get food by eating other organisms. Some protozoa prey on bacteria. Some are parasites of animals. Others graze on algae. Still others are decomposers that break down dead organic matter. 2. Almost all protozoa can move. They have special appendages for this purpose. You can see different types in Figure 9.3. Cilia (cilium, singular) are short, hair-like projections. Pseudopods are temporary extensions of the cytoplasm. Flagella are long, whip-like structures. Flagella are also found in most prokaryotes. Plant-like protists are commonly called algae (alga, singular). Some algae consist of single cells. They are called diatoms. Other algae are multicellular. An example is seaweed. Seaweed called kelp can grow as large as trees. You can see both a diatom and kelp in Figure 9.4. Algae are probably ancestors of plants. Algae are like plants mainly because they contain chloroplasts. This allows them to make food by photosynthesis. Algae are important producers in water-based ecosystems such as the ocean. On the other hand, algae lack other plant structures. For example, they dont have roots, stems, or leaves. Also unlike plants, some algae can move. They may move with pseudopods or flagella. Fungus-like protists include slime molds and water molds, both shown in Figure 9.5. They exist", "pos": "Bacteria are the most abundant living things on Earth. They live in almost all environments. They are found in the air, ocean, soil, and intestines of animals. They are even found in rocks deep below Earths surface. Any surface that has not been sterilized is likely to be covered with bacteria. The total number of bacteria in the world is amazing. Its estimated to be about 5 million trillion trillion. If you write that number in digits, it has 30 zeroes! Bacteria are the most diverse organisms on Earth. Thousands of species of bacteria have been discovered. Many more are thought to exist. The known species are classified on the basis of various traits. For example, they may be classified by the shape of their cells. They may also be classified by how they react to a dye called Gram stain. Bacteria come in several different shapes. The different shapes can be seen by examining bacteria under a light microscope. Therefore, its relatively easy to classify them by shape. There are three types of bacteria based on shape: bacilli (bacillus, singular), or rod shaped. cocci (coccus, singular), or sphere shaped. spirilli (spirillus, singular), or spiral shaped. You can see a common example of each type of bacteria in Figure 8.10. Different types of bacteria stain a different color when Gram stain is applied to them. This makes them easy to identify. Some stain purple and some stain red, as you can see in Figure 8.11. The two types differ in their outer layers. This explains why they stain differently. Bacteria that stain purple are called gram-positive bacteria. They have a thick cell wall without an outer membrane. Bacteria that stain red are called gram-negative bacteria. They have a thin cell wall with an outer membrane. Bacteria and people have many important relationships. Bacteria make our lives easier in a variety of ways. In fact, we could not survive without them. On the other hand, many bacteria can make us sick. Some of them are even deadly. For a dramatic overview of the many roles of bacteria, watch this stunning video: MEDIA Click image to the left or use the URL below. URL: Bacteria help usand all other living thingsby decomposing wastes. In this way, they recycle carbon and nitrogen in ecosystems. In addition, photosynthetic cyanobacteria are important producers. On ancient Earth, they added oxygen to the atmosphere and changed the course of evolution forever. There are billions of bacteria inside the human digestive tract. They help us digest food. They also make vitamins and play other important roles. We use bacteria in many other ways as well. For example, we use them to: create medical products such as vaccines. transfer genes in gene therapy. make fuels such as ethanol. clean up oil spills. kill plant pests. ferment foods. Do you eat any of the fermented foods pictured in Figure 8.12? If so, you are eating bacteria and their wastes. Yum! You have ten times as many bacterial cells as human cells in your body. Luckily for you, most of these bacteria are harmless. However, some of them can cause disease. Any organism that causes disease is called a pathogen. Diseases caused by bacterial pathogens include food poisoning, strep throat, and Lyme disease. Bacteria that cause disease may spread directly from person to person. For example, they may spread when people shake hands with, or sneeze on, other people. Bacteria may also spread through food, water, or objects that have become contaminated with them. Some bacteria are spread by vectors. A vector is an organism that spreads bacteria or other pathogens. Most vectors are animals, commonly insects. For example, deer ticks like the one in Figure 8.13 spread Lyme disease. Ticks carry Lyme disease bacteria from deer to people when they bite them. Bacteria in food or water usually can be killed by heating it to a high temperature. Generally, this temperature is at least 71 C (160 F). Bacteria on surfaces such as countertops and floors can be killed with disinfectants, such as chlorine", "neg": "The rock cycle, illustrated in Figure 1.1, depicts how the three major rock types - igneous, sedimentary, and meta- morphic - convert from one to another. Arrows connecting the rock types represent the processes that accomplish these changes. Rocks change as a result of natural processes that are taking place all the time. Most changes happen very slowly. Rocks deep within the Earth are right now becoming other types of rocks. Rocks at the surface are lying in place before they are next exposed to a process that will change them. Even at the surface, we may not notice the changes. The rock cycle has no beginning or end. Rocks are classified into three major groups according to how they form. These three types are described in more detail in other concepts in this chapter, but here is a summary. The Rock Cycle. Igneous rocks form from the cooling and hardening of molten magma in many different environments. The chemical composition of the magma and the rate at which it cools determine what rock forms. Igneous rocks can cool slowly beneath the surface or rapidly at the surface. These rocks are identified by their composition and texture. More than 700 different types of igneous rocks are known. Sedimentary rocks form by the compaction and cementing together of sediments, broken pieces of rock-like gravel, sand, silt, or clay. Those sediments can be formed from the weathering and erosion of preexisting rocks. Sedimentary rocks also include chemical precipitates, the solid materials left behind after a liquid evaporates. Metamorphic rocks form when the minerals in an existing rock are changed by heat or pressure below the surface. Click image to the left or use the URL below. URL: Several processes can turn one type of rock into another type of rock. The key processes of the rock cycle are crystallization, erosion and sedimentation, and metamorphism. Magma cools either underground or on the surface and hardens into an igneous rock. As the magma cools, different crystals form at different temperatures, undergoing crystallization. For example, the mineral olivine crystallizes out of magma at much higher temperatures than quartz. The rate of cooling determines how much time the crystals will have to form. Slow cooling produces larger crystals. Weathering wears rocks at the Earths surface down into smaller pieces. The small fragments are called sediments. Running water, ice, and gravity all transport these sediments from one place to another by erosion. During sedimen- tation, the sediments are laid down or deposited. In order to form a sedimentary rock, the accumulated sediment must become compacted and cemented together. When a rock is exposed to extreme heat and pressure within the Earth but does not melt, the rock becomes meta- morphosed. Metamorphism may change the mineral composition and the texture of the rock. For that reason, a metamorphic rock may have a new mineral composition and/or texture.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}340{"query": "Plunkett finished the game with 16 out of 25 pass completions for 172 yards and a touchdown. Theismann threw for more yards than Plunkett (243), but was just 16 out of 35 and was intercepted twice. He was also sacked six times. Branch was the top receiver of the game with six receptions for 94 yards and a touchdown. Guy punted seven times for 299 yards (42.7 average), with 244 net yards (34.8 average) and planted five of his seven punts inside the 20. Martin recorded a sack, a pass deflection, and a fumble recovery. Riggins, who had rushed for over 100 yards in his last six postseason games, was held to 64 yards and a touchdown on 26 carries, with his longest gain being just 8 yards. Brown was their top receiver with three receptions for 93 yards. Tight end Clint Didier caught five passes for 65 yards. Garrett recorded 100 yards on kickoff returns, and one reception for 17 yards. Part of both of Allens touchdown runs were cutbacks, which, according to New York Daily News writer Larry Fox, burned an overpursuing Redskins defense.", "pos": "Coming off their win over the Browns, the Bears stayed at home for a Week 9 duel with the Arizona Cardinals. Chicago would trail early in the first quarter as Cardinals quarterback Kurt Warner hooked up with wide receiver Larry Fitzgerald on an 11-yard touchdown pass. The Bears would answer as quarterback Jay Cutler competed a 33-yard touchdown pass to tight end Greg Olsen, but Arizona came right back as Warner hooked up with tight end Ben Patrick on a 6-yard touchdown pass. Chicago would find themselves in a huge deficit in the second quarter as Warner completed a 17-yard touchdown pass to Fitzpatrick and a 15-yard touchdown pass to tight end Anthony Becht, followed by kicker Neil Rackers nailing a 43-yard field goal. The Cardinals would add onto their lead as Rackers booted a 30-yard field goal in the third quarter. The Bears tried to rally in the fourth quarter as Cutler connected with Olsen on a 3-yard and a 20-yard touchdown pass, but Arizona pulled away with Warner completing a 4-yard touchdown pass to wide receiver Steve Breaston.", "neg": "This game is well known for an infamous penalty that occurred during the overtime period. The Jets were lining up for a game winning 56-yard field goal in overtime to try and give them the win. Nick folk kicked the ball, but the kick went wide right and the Patriots appeared to be taking over with a chance to win. However, Chris Jones of New England was called for a controversial unsportsmanlike conduct penalty after pushing his teammate into the offensive line. This penalty would later be named \"leaping\". The penalty gave the Jets another chance and made the field goal attempt a 51-yard attempt. This time, Folk drilled the kick, and the Jets would go on to stun the Patriots. With the win, the Jets improved to 4-3.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}341{"query": "On 27 January 2014, Ryanair moved into their new 20m, 100,000 sq ft Dublin Head Office in Airside Business Park, having outgrown their previous office based within Dublin Airport.", "pos": "Arik Air's head office is the Arik Air Aviation Center on the grounds of Murtala Muhammed International Airport in Ikeja, Lagos State.", "neg": "Armstrong Siddeley was merged with the aircraft engine business of Bristol Aeroplane Company (Bristol Aero Engines) to form Bristol Siddeley as part of an ongoing rationalisation under government influence of the British aircraft and aircraft engine manufacturers.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}342{"query": "He retired to the Villa Bianca (now named ''Villa Grock''), a 50-room house he had had built in the 1920s in Imperia, Italy, where he died in 1959.", "pos": "Francesco Gessi (20 January 1588 -- 1649) was an Italian painter of the Baroque period, active mainly in Bologna.", "neg": "The Villa Empain is a private house in the Art Deco style designed and built between 1930 and 1934 by Swiss architect Michel Polak for Baron Louis Empain, son of Belgian industrialist Baron Edouard Empain, located in Brussels, Belgium.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}343{"query": "The study of rock strata is called stratigraphy. The laws of stratigraphy can help scientists understand Earths past. The laws of stratigraphy are usually credited to a geologist from Denmark named Nicolas Steno. He lived in the 1600s. The laws are illustrated in Figure 11.6. Refer to the figure as you read about the laws below. Superposition refers to the position of rock layers and their relative ages. Relative age means age in comparison with other rocks, either younger or older. The relative ages of rocks are important for understanding Earths history. New rock layers are always deposited on top of existing rock layers. Therefore, deeper layers must be older than layers closer to the surface. This is the law of superposition. You can see an example in Figure 11.7. Rock layers extend laterally, or out to the sides. They may cover very broad areas, especially if they formed at the bottom of ancient seas. Erosion may have worn away some of the rock, but layers on either side of eroded areas will still match up. Look at the Grand Canyon in Figure 11.8. Its a good example of lateral continuity. You can clearly see the same rock layers on opposite sides of the canyon. The matching rock layers were deposited at the same time, so they are the same age. Sediments were deposited in ancient seas in horizontal, or flat, layers. If sedimentary rock layers are tilted, they must have moved after they were deposited. Rock layers may have another rock cutting across them, like the igneous rock in Figure 11.9. Which rock is older? To determine this, we use the law of cross-cutting relationships. The cut rock layers are older than the rock that cuts across them. Geologists can learn a lot about Earths history by studying sedimentary rock layers. But in some places, theres a gap in time when no rock layers are present. A gap in the sequence of rock layers is called an unconformity. Look at the rock layers in Figure 11.10. They show a feature called Huttons unconformity. The unconformity was discovered by James Hutton in the 1700s. Hutton saw that the lower rock layers are very old. The upper layers are much younger. There are no layers in between the ancient and recent layers. Hutton thought that the intermediate rock layers eroded away before the more recent rock layers were deposited. Huttons discovery was a very important event in geology! Hutton determined that the rocks were deposited over time. Some were eroded away. Hutton knew that deposition and erosion are very slow. He realized that for both to occur would take an extremely long time. This made him realize that Earth must be much older than people thought. This was a really big discovery! It meant there was enough time for life to evolve gradually. When rock layers are in the same place, its easy to give them relative ages. But what if rock layers are far apart? What if they are on different continents? What evidence is used to match rock layers in different places? Some rock layers extend over a very wide area. They may be found on more than one continent or in more than one country. For example, the famous White Cliffs of Dover are on the coast of southeastern England. These distinctive rocks are matched by similar white cliffs in France, Belgium, Holland, Germany, and Denmark (see Figure 11.11). It is important that this chalk layer goes across the English Channel. The rock is so soft that the Channel Tunnel connecting England and France was carved into it! Like index fossils, key beds are used to match rock layers. A key bed is a thin layer of rock. The rock must be unique and widespread. For example, a key bed from around the time that the dinosaurs went extinct is very important. A thin layer of clay was deposited over much of Earths surface. The clay has large amount of the element iridium. Iridium is rare on Earth but common in asteroids. This unusual clay layer has been used to match rock up layers all over the world. It also led to the hypothesis that a giant asteroid struck Earth and caused the", "pos": "The outcrop in the Figure 1.1 is at Checkerboard Mesa in Zion National Park, Utah. It has a very interesting pattern on it. As a geology student you may ask: how did this rock form? If you poke at the rock and analyze its chemistry you will see that its made of sand. In fact, the rock formation is called the Navajo sandstone. But knowing that the rock is sandstone doesnt tell you how it formed. It would be hard to design an experiment to show how this rock formed. But we can make observations now and apply them to this rock that formed long ago. James Hutton came up with this idea in the late 1700s. The present is the key to the past. He called this the principle of uniformitarianism. It is that if we can understand a geological process now and we find evidence of that same Checkerboard Mesa in Zion National Park, Utah. process in the past, then we can assume that the process operated the same way in the past. Hutton speculated that it has taken millions of years to shape the planet, and it is continuing to be changed. He said that there are slow, natural processes that changed, and continue to change, the planets landscape. For example, given enough time, a stream could erode a valley, or sediment could accumulate and form a new landform. Lets go back to that outcrop. What would cause sandstone to have layers that cross each other, a feature called cross-bedding? In the photo of the Mesquite sand dune in Death Valley National Park, California (Figure 1.2), we see that wind can cause cross-bedding in sand. Cross-bedding is due to changes in wind direction. There are also ripples caused by the wind waving over the surface of the dune. Since we can observe wind forming sand dunes with these patterns now, we have a good explanation for how the Navajo sandstone formed. The Navajo sandstone is a rock formed from ancient sand dunes in which wind direction changed from time to time. This is just one example of how geologists use observations they make today to unravel what happened in Earths past. Rocks formed from volcanoes, oceans, rivers, and many other features are deciphered by looking at the geological work those features do today. Click image to the left or use the URL below. URL:", "neg": "Stress is the force applied to an object. In geology, stress is the force per unit area that is placed on a rock. Four types of stresses act on materials. A deeply buried rock is pushed down by the weight of all the material above it. Since the rock cannot move, it cannot deform. This is called confining stress. Compression squeezes rocks together, causing rocks to fold or fracture (break) (Figure 1.1). Compression is the most common stress at convergent plate boundaries. Stress caused these rocks to fracture. Rocks that are pulled apart are under tension. Rocks under tension lengthen or break apart. Tension is the major type of stress at divergent plate boundaries. When forces are parallel but moving in opposite directions, the stress is called shear (Figure 1.2). Shear stress is the most common stress at transform plate boundaries. Shearing in rocks. The white quartz vein has been elongated by shear. When stress causes a material to change shape, it has undergone strain or deformation. Deformed rocks are common in geologically active areas. A rocks response to stress depends on the rock type, the surrounding temperature, the pressure conditions the rock is under, the length of time the rock is under stress, and the type of stress. Rocks have three possible responses to increasing stress (illustrated in Figure 1.3): elastic deformation: the rock returns to its original shape when the stress is removed. plastic deformation: the rock does not return to its original shape when the stress is removed. fracture: the rock breaks. Under what conditions do you think a rock is more likely to fracture? Is it more likely to break deep within Earths crust or at the surface? What if the stress applied is sharp rather than gradual? At the Earths surface, rocks usually break quite quickly, but deeper in the crust, where temperatures and pressures are higher, rocks are more likely to deform plastically. Sudden stress, such as a hit with a hammer, is more likely to make a rock break. Stress applied over time often leads to plastic deformation. Click image to the left or use the URL below. URL:", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}344{"query": "The Bristol Lodekka was a low-height double-decker bus built by Bristol Commercial Vehicles in England.", "pos": "MS Viking Cinderella is a cruiseferry built in 1989 at Wartsila Marine Perno Shipyard in Turku, Finland, as MS Cinderella for SF Line, one of the owners of the Viking Line consortium.", "neg": "The Volvo B12M is an underfloor-engined bus/coach chassis introduced by Volvo Buses in 2001 as a replacement for the Volvo B10M.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}345{"query": "As of the census of 2000, there were 445,342 people, 169,162 households, and 114,015 families residing in the county. The population density was 615 people per square mile (238/km). There were 178,913 housing units at an average density of 247 per square mile (95/km). The racial makeup of the county was 82.19% Race (United States Census), 1.15% Race (United States Census) or Race (United States Census), 0.65% Race (United States Census), 6.68% Race (United States Census), 0.30% Race (United States Census), 5.86% from Race (United States Census), and 3.17% from two or more races. 11.17% of the population were Race (United States Census) or Race (United States Census) of any race. 17.2% were of German American, 9.9% English American, 8.2% Irish American, and 6.7% Americans ancestry. 81.7% spoke only English at home, while 9.6% spoke Spanish and 1.2% Vietnamese.", "pos": "As of the census of 2000, there were 218,590 people, 79,667 households, and 60,387 families residing in the county. The population density was 496 people per square mile (192/km). There were 83,146 housing units at an average density of 189 per square mile (73/km). The racial makeup of the county was 86.77% Race (United States Census), 9.27% Race (United States Census), 0.23% Race (United States Census), 1.52% Race (United States Census), 0.06% Race (United States Census), 0.69% from Race (United States Census), and 1.47% from two or more races. 1.91% of the population were Race (United States Census) or Race (United States Census) of any race. 22.5% were of German people, 13.1% Irish people, 9.8% Italian people, 9.2% English, 8.1% \"American\" and 6.0% Polish ancestry.", "neg": "As of the census of 2000, there were 35,100 people, 12,759 households, and 9,071 families residing in the county. The population density was 59 people per square mile (23/km). There were 15,035 housing units at an average density of 25 per square mile (10/km). The racial makeup of the county was 85.8% Race (United States Census), 3.9% Race (United States Census) or Race (United States Census), 1.8% Race (United States Census), 1.0% Race (United States Census), 0.1% Race (United States Census), 5.0% from Race (United States Census), and 2.4% from two or more races. 8.9% of the population were Race (United States Census) or Race (United States Census) of any race. 14.9% were of German people, 12.6% English people, 11.7% Irish people, 8.8% Italian people and 7.3% United States ancestry according to Census 2000. 93.1% spoke English language and 5.1% Spanish language as their first language.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}346{"query": "Stockholm Monsters were a post-punk band from Burnage in Manchester who recorded for Factory Records between 1981 and 1987.", "pos": "City Reign are an indie rock band from Manchester, England.", "neg": "In 1989, Z Channel faded to black and was replaced by SportsChannel Los Angeles.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}347{"query": "We have determined sequences of PCR-amplified B1 elements from hamster and rat (Myomorpha), chipmunk (Sciuromorpha), and guinea pig (Caviomorpha). Between three and six B1 subfamilies were found in these species. In the phylogenetic analysis B1 sequences of hamster, mouse, and rat clustered separately from those of chipmunk and those of guinea pig. This is consistent with an independent evolution of B1 elements in separate rodent lineages. We exclude the possibility of convergent mutations to explain certain diagnostic characters within the modern B1 quasi-dimers and view these elements as mosaic structures assembling preexisting mutations. Furthermore, the presence of Alu-like structural motifs supports the hypothesis of the monophyletic origin of Alu and B1 repeats, i.e., from a common 7SL RNA-derived retroposing monomeric element.", "pos": "SECIS elements are stem-loop structures located in the 3' untranslated regions (UTRs) of eukaryotic selenoprotein mRNAs that are required for directing cotranslational selenocysteine incorporation at UGA codons. In prokaryotes, stem-loops mediating selenocysteine incorporation are located immediately downstream of the UGA selenocysteine codon, in the coding region. Previous characterization studies of the mammalian SECIS elements of type 1 deiodinase, glutathione peroxidase, and selenoprotein P showed that conserved nucleotides in the loops and unpaired bulges, and base pairing in the stems are required for SECIS function. These initial studies utilized approximately 175-230-nt segments of the 3'UTRs of the selenoprotein mRNAs. Here we define the minimal functional rat type 1 deiodinase SECIS element, a 45-nt segment, the 5' boundary of which corresponds precisely to the 5'-most critical conserved nucleotide identified previously. We also define base pairing requirements in the stem of this element. In view of the presence of SECIS elements in the open reading frames (ORFs) of bacterial selenoproteins, we examine the effects in the type 1 deiodinase of extending the ORF into the SECIS element, and find that this dramatically inhibits SECIS function. Finally, we define a minimal spacing requirement of 51-111 nt between a eukaryotic UGA selenocysteine codon and SECIS element.", "neg": "Mitochondrial (mt) genomes from diverse phylogenetic groups vary considerably in size, structure and organization. The genus Plasmodium, the causative agent of malaria, has the smallest mt genome in the form of a tandemly repeated, linear element of 6 kb. The Plasmodium mt genome encodes only three protein genes (cox1, cox3 and cob) and large- and small-subunit ribosomal RNA (rRNA) genes, which are highly fragmented with 19 identified rRNA pieces. The complete mt genome sequences of 21 Plasmodium species have been published but a thorough investigation of the arrangement of rRNA gene fragments has been undertaken for only Plasmodium falciparum, the human malaria parasite. In this study, we determined the arrangement of mt rRNA gene fragments in 23 Plasmodium species, including two newly determined mt genome sequences from P. gallinaceum and P. vinckei vinckei, as well as Leucocytozoon caulleryi, an outgroup of Plasmodium. Comparative analysis reveals complete conservation of the arrangement of rRNA gene fragments in the mt genomes of all the 23 Plasmodium species and L. caulleryi. Surveys for a new rRNA gene fragment using hidden Markov models enriched with recent mt genome sequences led us to suggest the mtR-26 sequence as a novel candidate LSU rRNA fragment in the mt genomes of the 24 species. Additionally, we found 22-25 bp-inverted repeat sequences, which may be involved in the generation of lineage-specific mt genome arrangements after divergence from a common ancestor of the genera Eimeria and Plasmodium/Leucocytozoon.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}348{"query": "Knight Lore is a 1984 action-adventure game by Ultimate Play the Game known for popularising isometric graphics in video games.", "pos": "Two Worlds II is an action role-playing game developed by Polish video game developer Reality Pump and published by TopWare Interactive as a sequel to 2007's Two Worlds.", "neg": "The 1988 Dungeons & Dragons role-playing game module Ruins of Adventure was produced using the same adventure scenario as Pool of Radiance, using the same plot, background, setting, and many of the same characters as the computer game.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}349{"query": "Cells were first discovered in the mid-1600s. The cell theory came about some 200 years later. You can see a re- enactment of some of the discoveries that led to the cell theory in this video: MEDIA Click image to the left or use the URL below. URL: British scientist Robert Hooke first discovered cells in 1665. He was one of the earliest scientists to study living things under a microscope. He saw that cork was divided into many tiny compartments, like little rooms. (Do the cells in Figure 3.1 look like little rooms to you too?) Hooke called these little rooms cells. Cork comes from trees, so what Hooke observed was dead plant cells. In the late 1600s, Dutch scientist Anton van Leeuwenhoek made more powerful microscopes. He used them to observe cells of other organisms. For example, he saw human blood cells and bacterial cells. Over the next century, microscopes were improved and more cells were observed. By the early 1800s, scientists had seen cells in many different types of organisms. Every organism that was examined was found to consist of cells. From all these observations, German scientists Theodor Schwann and Matthias Schleiden drew two major conclusions about cells. They concluded that: cells are alive. all living things are made of cells. Around 1850, a German doctor named Rudolf Virchow was observing living cells under a microscope. As he was watching, one of the cells happened to divide. Figure 3.2 shows a cell dividing, like the cell observed by Virchow. This was an aha moment for Virchow. He realized that living cells produce new cells by dividing. This was evidence that cells arise from other cells. The work of Schwann, Schleiden, and Virchow led to the cell theory. This is one of the most important theories in life science. The cell theory can be summed up as follows: All organisms consist of one or more cells. Cells are alive and the site of all life processes. All cells come from pre-existing cells. All cells have certain parts in common. These parts include the cell membrane, cytoplasm, DNA, and ribosomes. The cell membrane is a thin coat of phospholipids that surrounds the cell. Its like the skin of the cell. It forms a physical boundary between the contents of the cell and the environment outside the cell. It also controls what enters and leaves the cell. The cell membrane is sometimes called the plasma membrane. Cytoplasm is the material inside the cell membrane. It includes a watery substance called cytosol. Besides water, cytosol contains enzymes and other substances. Cytoplasm also includes other cell structures suspended in the cytosol. DNA is a nucleic acid found in cells. It contains genetic instructions that cells need to make proteins. Ribosomes are structures in the cytoplasm where proteins are made. They consist of RNA and proteins. These four components are found in all cells. They are found in the cells of organisms as different as bacteria and people. How did all known organisms come to have such similar cells? The answer is evolution. The similarities show that all life on Earth evolved from a common ancestor. Besides the four parts listed above, many cells also have a nucleus. The nucleus of a cell is a structure enclosed by a membrane that contains most of the cells DNA. Cells are classified in two major groups based on whether or not they have a nucleus. The two groups are prokaryotic cells and eukaryotic cells. Prokaryotic cells are cells that lack a nucleus. The DNA in prokaryotic cells is in the cytoplasm, rather than enclosed within a nuclear membrane. All the organisms in the Bacteria and Archaea Domains have prokaryotic cells. No other organisms have this type of cell. Organisms with prokaryotic cells are called prokaryotes. They are all single-celled organisms. They were the first type of organisms to evolve. They are still the most numerous organisms today. You can see a model of a prokaryotic cell in Figure 3.3. The cell in the figure is a bacterium. Notice how it contains a cell membrane, cytoplasm, ribosomes, and several other structures. However, the cell lacks a nucleus. The cells DNA is circular.", "pos": "A cell is the smallest structural and functional unit of an organism. Some organisms, like bacteria, consist of only one cell. Big organisms, like humans, consist of trillions of cells. Compare a human to a banana. On the outside, they look very different, but if you look close enough youll see that their cells are actually very similar. Most cells are so small that you cannot see them without the help of a microscope. It was not until 1665 that English scientist Robert Hooke invented a basic light microscope and observed cells for the first time, by looking at a piece of cork. You may use light microscopes in the classroom. You can use a light microscope to see cells ( Figure 1.1). But many structures in the cell are too small to see with a light microscope. So, what do you do if you want to see the tiny structures inside of cells? In the 1950s, scientists developed more powerful microscopes. A light microscope sends a beam of light through a specimen, or the object you are studying. A more powerful microscope, called an electron microscope, passes a beam of electrons through the specimen. Sending electrons through a cell allows us to see its smallest parts, even the parts inside the cell ( Figure 1.2). Without electron microscopes, we would not know what the inside of a cell looked like. The outline of onion cells are visible under a light microscope. In 1858, after using microscopes much better than Hookes first microscope, Rudolf Virchow developed the hypoth- esis that cells only come from other cells. For example, bacteria, which are single-celled organisms, divide in half (after they grow some) to make new bacteria. In the same way, your body makes new cells by dividing the cells you already have. In all cases, cells only come from cells that have existed before. This idea led to the development of one of the most important theories in biology, the cell theory. Cell theory states that: 1. All organisms are composed of cells. 2. Cells are alive and the basic living units of organization in all organisms. 3. All cells come from other cells. As with other scientific theories, many hundreds, if not thousands, of experiments support the cell theory. Since Virchow created the theory, no evidence has ever been identified to contradict it. Although cells share many of the same features and structures, they also can be very different ( Figure 1.3). Each cell in your body is designed for a specific task. In other words, the cells function is partly based on the cells structure. For example: Red blood cells are shaped with a pocket that traps oxygen and brings it to other body cells. Nerve cells are long and stringy in order to form a line of communication with other nerve cells, like a wire. Because of this shape, they can quickly send signals, such as the feeling of touching a hot stove, to your brain. Skin cells are flat and fit tightly together to protect your body. As you can see, cells are shaped in ways that help them do their jobs. Multicellular (many-celled) organisms have many types of specialized cells in their bodies. Red blood cells (left) are specialized to carry oxygen in the blood. Neurons (cen- ter ) are shaped to conduct electrical im- pulses to many other nerve cells. These epidermal cells (right) make up the skin of plants. Note how the cells fit tightly together. While cells are the basic units of an organism, groups of cells can perform a job together. These cells are called specialized because they have a special job. Specialized cells can be organized into tissues. For example, your liver cells are organized into liver tissue. Your liver tissue is further organized into an organ, your liver. Organs are formed from two or more specialized tissues working together to perform a job. All organs, from your heart to your liver, are made up of an organized group of tissues. These organs are part of a larger system, the organ systems. For example, your brain works", "neg": "Many life science discoveries would not have been possible without the microscope. For example: Cells are the tiny building blocks of living things. They couldnt be discovered until the microscope was invented. The discovery of cells led to the cell theory. This is one of the most important theories in life science. Bacteria are among the most numerous living things on the planet. They also cause many diseases. However, no one knew bacteria even existed until they could be seen with a microscope. The invention of the microscope allowed scientists to see cells, bacteria, and many other structures that are too small to be seen with the unaided eye. It gave them a direct view into the unseen world of the extremely tiny. You can get a glimpse of that world in Figure 1.10. The microscope was invented more than four centuries ago. In the late 1500s, two Dutch eyeglass makers, Zacharias Jansen and his father Hans, built the first microscope. They put several magnifying lenses in a tube. They discovered that using more than one lens magnified objects more than a single lens. Their simple microscope could make small objects appear nine times bigger than they really were. In the mid-1600s, the English scientist Robert Hooke was one of the first scientists to observe living things with a microscope. He published the first book of microscopic studies, called Micrographia. It includes wonderful drawings of microscopic organisms and other objects. One of Hookes most important discoveries came when he viewed thin slices of cork under a microscope. Cork is made from the bark of a tree. When Hooke viewed it under a microscope, he saw many tiny compartments that he called cells. He made the drawing in Figure 1.11 to show what he observed. Hooke was the first person to observe the cells from a once-living organism. In the late 1600s, Anton van Leeuwenhoek, a Dutch lens maker and scientist, started making much stronger microscopes. His microscopes could magnify objects as much as 270 times their actual size. Van Leeuwenhoek made many scientific discoveries using his microscopes. He was the first to see and describe bacteria. He observed them in a sample of plaque that he had scraped off his own teeth. He also saw yeast cells, human sperm cells, and the microscopic life teeming in a drop of pond water. He even saw blood cells circulating in tiny blood vessels called capillaries. The drawings in Figure 1.12 show some of tiny organisms and living cells that van Leeuwenhoek viewed with his microscopes. He called them animalcules. These early microscopes used lenses to refract light and create magnified images. This type of microscope is called a light microscope. Light microscopes continued to improve and are still used today. The microscope you might use in science class is a light microscope. The most powerful light microscopes now available can make objects look up to 2000 times their actual size. You can learn how to use a light microscope by watching this short video: http MEDIA Click image to the left or use the URL below. URL: To see what you might observe with a light microscope, watch the following video. It shows some amazing creatures in a drop of stagnant water from an old boat. What do you think the creatures might be? Do they look like any of van Leeuwenhoeks animalcules in Figure 1.12? MEDIA Click image to the left or use the URL below. URL: For an object to be visible with a light microscope, it cant be smaller than the wavelength of visible light (about 550 nanometers). To view smaller objects, a different type of microscope, such as an electron microscope, must be used. Electron microscopes pass beams of electrons through or across an object. They can make a very clear image that is up to 2 million times bigger than the actual object. An electron microscope was used to make the image of the ant head in Figure 1.10.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}350{"query": "Mkuki na Nyota Publishers Ltd (MNP) is a book publishing company that was founded in 1991 in response to the general absence of independent scholarly publishing in Tanzania.", "pos": "Sigma Editions is an independent record label founded in 1998 by Rosy Parlane and Dion Workman (both ex-members of Thela).", "neg": "Mathematical Models and Methods in Applied Sciences is a journal founded in 1991 and published by World Scientific.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}351{"query": "West of the Water Tower is a lost 1923 silent film comedy drama produced by Famous Players-Lasky and distributed by Paramount Pictures.", "pos": "Mr. Flip is a 1909 American silent comedy film made by Essanay Studios, directed by Gilbert M. 'Broncho Billy' Anderson and starring Ben Turpin.", "neg": "Min and Bill is a 1930 American Pre-Code comedy-drama film starring Marie Dressler and Wallace Beery and based on Lorna Moon's novel Dark Star, adapted by Frances Marion and Marion Jackson.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}352{"query": "As Tsushima had suffered greatly from its loss of trade with Korea as a result of the invasions, Yoshitoshi of the So family, then dominant in Tsushima, undertook the lead in the peace negotiations by Japan. He sent four peace missions to Joseon in 1599 to normalize relations. The first three were captured and sent directly to Beijing by Chinese troops, but the fourth one, in 1601, successfully obtained from the Joseon court the promise of a normalizing of relations upon the return of remaining Joseon captives. As Ming troops continued to be present in Korea following the withdrawal of Japanese forces, the major incentive for Joseon for the normalization of relations with Japan was the withdrawal of the Chinese soldiers from their territory. The Ming Chinese themselves were causing as much havoc as the Japanese had during the actual conflict, and their presence continued to strain Joseon's national economy and infrastructure. In response to the Joseon request, Yoshitoshi promptly released several Joseon prisoners and between 1603 and 1604 helped the Joseon envoys to repatriate a further 3,000 by organizing negotiations at Kyoto with Tokugawa Ieyasu, by then the Shogun of Japan. In the continuation of the diplomatic talks toward peaceful relations, Joseon in 1606 expanded its conditions and demanded that the Shogun write a formal letter requesting peace, and to extradite the Japanese soldiers who had defiled the Joseon Royal Tombs near Hanseong . Realizing that the Shogunate would never agree to such a request, Yoshitoshi sent a forged letter and a group of criminals instead; the great need to expel the Ming soldiers pushed Joseon into accepting and to send an emissary in 1608. The end result was a return of Joseon prisoners and the restoration of diplomatic and trade relations between the two countries.", "pos": "In 1740, the Mon of Lower Burma revolted against the Toungoo Dynasty and founded the Restored Hanthawaddy Kingdom based in Pegu . Throughout the 1740s, the Hanthawaddy forces were winning against Upper Burma-based Toungoo armies. The Siamese were concerned by another rising power in Burma since a strong Burma historically meant future invasions to Siam. Concerned, the Siamese court readily gave protection to the Burmese governors of Martaban and Tavoy who had fled to Siam. In 1745, they sent a diplomatic mission to Ava to evaluate the political situation there, and were received by the Burmese king Mahadhammaraza Dipadi. They saw an Ava court that was on its last legs. By 1751, Restored Hanthawaddy forces were closing in on Ava. The Siamese concerns about the emergence of another strong dynasty based in Pegu appeared imminent. Perhaps as a precautionary measure, the Siamese decided to move their forward base into the upper coast in 1751. While it remains unclear as to whether the Siamese ever intended to go beyond the coast into mainland Lower Burma, the Siamese action nonetheless rang alarm bells in Pegu. Deeply concerned, the Hanthawaddy leadership withdrew two-thirds of their army back down to Lower Burma immediately after they had toppled the last Toungoo king in April 1752. This redeployment of Hanthawaddy troops proved a critical turning point in Burmese history as it gave nascent Upper Burmese resistance groups much needed breathing room. The Hanthawaddy command left less than 10,000 men to pacify all of Upper Burma. Taking advantage of light Hanthawaddy troops, one resistance group, the Konbaung Dynasty led by Alaungpaya, drove out Hanthawaddy troops from Upper Burma by May 1754. Konbaung armies invaded Lower Burma in 1755, and captured Pegu in 1757, ending the 17-year-old Mon kingdom.", "neg": "Meanwhile, in 1274, the former Dali Kingdom was officially reorganized as the Province of Yunnan, with Sayyid Ajjal Shams al-Din Omar as governor. In May 1275, the governor sent a report to the emperor stating that the embassy had not returned; that the Burmese evidently had no intention of submitting; and that war was the only way forward. But the emperor rejected an outright invasion. Just coming off a disastrous Japanese campaign, the emperor was unwilling to commit the central government troops to what he considered a low priority affair. He was now focused on delivering the final blow against the Song; the emperor ordered the Yunnan provincial army to secure the borderlands in order to block the escape path of the Song refugees. He also sanctioned a limited border war if Pagan contested the takeover. As planned, the Yunnan army proceeded to consolidate the borderlands in 1275-76. Elsewhere, the main Mongol armies had captured most of the Song territory by 1276. By 1277, at least one Burmese vassal state named \"Gold Teeth\" had submitted to the Mongols. Like in 1272, the Burmese government responded by sending an army to reclaim the rebellious state; but unlike in 1272, the Mongols had posted a sizable garrison there. Though it was ultimately under Mongol command, many of the officers and most of the soldiers of the garrison were Turkic-speaking peoples or people from the further west: Turks from Samarkand, Bukhara, Merv and Nishapur, but also captive soldiers from the Persian Khwarazmid empire, the Kipchaks, and even Bulgars from the lower Volga.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}353{"query": "The SP790 study (ClinicalTrials.gov, NCT00136045) showed benefits of rotigotine over placebo in improving symptom severity of restless legs syndrome (RLS), also known as Willis-Ekbom disease, on the International Restless Legs Syndrome Study Group rating scale (IRLS), Clinical Global Impression item 1 (CGI-1), RLS 6-item questionnaire (RLS-6), and the RLS-quality of life questionnaire (RLS-QoL) in patients with moderate to severe idiopathic RLS. To provide clinical context for the IRLS and to guide the choice of assessment scales for RLS studies, our post hoc analysis of SP790 data evaluated associations between the IRLS and the CGI-1, IRLS and RLS-6, and the IRLS and RLS-QoL. Scale associations were analyzed at baseline and at the end of maintenance (EoM) using data from the safety set (rotigotine and placebo groups combined [n=458]). Changes from baseline to EoM in IRLS score vs comparator scale scores also were analyzed. There was a trend towards increasing IRLS severity category with increasing CGI-1, RLS-6, and RLS-QoL score. Pearson product moment correlation coefficients showed correlations between IRLS and comparator scale scores at baseline and EoM as well as correlations for change from baseline to EoM. Correlations between the IRLS and comparator scales were substantial. These data indicate that the IRLS is clinically meaningful. The IRLS and CGI-1 are generally sufficient to evaluate the overall severity and impact of RLS symptoms in clinical trials.", "pos": "Restless legs syndrome (RLS), also known as Willis-Ekbom disease, is characterised by abnormal sensations in the legs as well as dysaesthesia. Although the aetiology of RLS has not yet been determined, it may be associated with systemic inflammation. The neutrophil-to-lymphocyte ratio (NLR) is a new and simple marker indicating systemic inflammation. The present study aimed to investigate the relationship between systemic inflammation and RLS through the use of the NLR. A total of 75 newly diagnosed patients with RLS and 56 healthy control subjects were included in the study. Baseline NLR was calculated by dividing the absolute neutrophil count by the absolute lymphocyte count. The NLRs of the two groups were compared. There were no significant differences in gender and age between the two groups. The NLR was 1.96 0.66 in the patient group and 1.67 0.68 in the control group (p = 0.005). Receiver operating characteristic analysis was performed to determine the cut-off value of NLR to predict RLS. The NLR was predictive at 1.58 with a 64% sensitivity and 50% specificity (95% confidence interval 0.55-0.74, area under curve 0.648 0.05). The NLR was found to be statistically higher in patients with RLS and may be used to predict RLS. The aetiology of RLS remains undetermined. The present study showed that systemic inflammation may play a role in RLS. However, RLS could also be associated with systemic inflammatory diseases. This relationship is supported by high NLR values, which are related to chronic systemic inflammation.", "neg": "To investigate whether the effects of nerve growth factor (NGF) inhibition with tanezumab on rats with medial meniscal tear (MMT) effectively model rapidly progressive osteoarthritis (RPOA) observed in clinical trials. Male Lewis rats underwent MMT surgery and were treated weekly with tanezumab (0.1, 1 or 10mg/kg), isotype control or vehicle for 7, 14 or 28days. Gait deficiency was measured to assess weight-bearing on the operated limb. Joint damage was assessed via histopathology. A second arm, delayed onset of treatment (starting 3-8weeks after MMT surgery) was used to control for analgesia early in the disease process. A third arm, mid-tibial amputation, evaluated the dependency of the model on weight-bearing. Gait deficiency in untreated rats was present 3-7days after MMT surgery, with a return to normal weight-bearing by days 14-28. Prophylactic treatment with tanezumab prevented gait deficiency and resulted in more severe cartilage damage. When onset of treatment with tanezumab was delayed to 3-8weeks after MMT surgery, there was no increase in cartilage damage. Mid-tibial amputation completely prevented cartilage damage in untreated MMT rats. These data suggest that analgesia due to NGF inhibition during the acute injury phase is responsible for increased voluntary weight-bearing and subsequent cartilage damage in the rat MMT model. This model failed to replicate the hypotrophic bone response observed in tanezumab-treated patients with RPOA.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}354{"query": "The Ehlers-Danlos syndrome encompasses a group of hereditary disorders of the connective tissue, characterized by hyperextensible skin, joint hypermobility; and varying degrees of vessel and tissue fragility. The main forms are classical, hypermobile, vascular, kyphoscoliotic A/B, arthrochalasis A/B and dermatosparaxis types. We report our experience in diagnosis and classification of Ehlers-Danlos-syndrome, especially with the combination of clinical and morphological criteria, at the Department of Dermatology of the University of Heidelberg with more than 600 patients between 1984 and 2004. We classified those types of EDS which are characterized by regular and characteristic ultrastructural changes in the dermal components, primarily collagen, including the classical, hypermobile and vascular types as well as the less-common arthrochalasis and dermatosparaxis types. The combination of clinical and morphologic features facilitates the selection of candidate genes for molecular genetic investigation. Besides the skin, skeleton and vessels, many other organ systems such as eyes and intestine, can be affected in Ehlers-Danlos syndrome. Accordingly, interdisciplinary cooperation (pediatrics, surgery, orthopedics, rheumatology, neurology, genetics) is necessary. As the connective tissue of the skin is accessible for biopsy and diagnostic investigation, dermatologists should be trained in the diagnostic approach and classification of this syndrome.", "pos": "The Ehlers-Danlos syndromes (EDS) are a group of heritable connective tissue disorders that share the common features of skin hyperextensibility, articular hypermobility, and tissue fragility. Considerable clinical and genetic heterogeneity exists, and more than nine separate forms have been recognized. Recent advances in the molecular analysis of EDS have identify defects responsible for EDS VI (homozygous and compound heterozygous mutations in the lysyl-hydroxylase gene), EDS VIIA and EDS VIIB (mutations in the type I collagene genes), EDS VIIC (deficiency of procollagen N-proteinase), EDS IX (mutations in the MNK gene), and EDS IV (mutations in the type III collagen gene). Of the various types of Ehlers-Danlos syndrome the most severe is type IV (EDS IV). Early studies showed that fibroblasts from EDS IV patients secreted lower than normal amounts of type III procollagen (Pope et al., 1975). Later, the disease was linked to COL3A1, the gene encoding this protein. More recently, with the publication of full length cDNA and partial characterisation of the gene structure, detailed analysis of mutations in EDS IV patients has become possible. Nineteen different mutations in the type III procollagen gene have been reported in different families with EDS IV. Recent results support the hypothesis that in EDS IV, dominant inheritance should be assumed, in sporadic cases also, unless proven otherwise. Very little is known about the genetics or biochemicals defects responsible for the others EDS subtypes, but with the applications of the tools of molecular biology, analysis of these defects if now within reach.", "neg": "Heme is critical for a variety of cellular processes, but excess intracellular heme may result in oxidative stress and membrane injury. Feline leukemia virus subgroup C receptor (FLVCR1), a member of the SLC49 family of four paralogous genes, is a cell surface heme exporter, essential for erythropoiesis and systemic iron homeostasis. Disruption of FLVCR1 function blocks development of erythroid progenitors, likely due to heme toxicity. Mutations of SLC49A1 encoding FLVCR1 are noted in patients with a rare neurodegenerative disorder: posterior column ataxia with retinitis pigmentosa. FLVCR2 is highly homologous to FLVCR1 and may function as a cellular heme importer. Mutations of SLC49A2 encoding FLVCR2 are observed in Fowler syndrome, a rare proliferative vascular disorder of the brain. The functions of the remaining members of the SLC49 family, MFSD7 and DIRC2 (encoded by the SLC49A3 and SLC49A4 genes), are unknown, although the latter is implicated in hereditary renal carcinomas. SLC48A1 (heme responsive gene-1, HRG-1), the sole member of the SLC48 family, is associated with the endosome and appears to transport heme from the endosome into the cytosol.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}355{"query": "The 2016 World Single Distance Speed Skating Championships will be held between 11 and 14 February 2016 in Kolomna, Russia.", "pos": "The 2013 International Championship was a professional ranking snooker tournament that took place between 27 October and 3 November 2013 at the Chengdu Eastern Music Park in Chengdu, China.", "neg": "Milan Sablik (Czech pronunciation: (mlan sablik); Zdar nad Sazavou, 14 March 1991) is a Czech speedskater and the younger brother of Martina Sablikova, the 2007 European Champion and double World Single Distances Champion.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}356{"query": "At the dedication ceremony the Secretary of State said the following words about him: ''One voice that should have spoken here today is silent, but many of us cannot forget or cease to mourn and to honor our dear and noble friend, Joaquim Nabuco. Ambassador from Brazil, dean of the American diplomatic corps, respected, admired, trusted, loved and followed by all of us, he was a commanding figure in the international movement of which the creation of this building is part...'' (Citation: Ronald Hilton and Alexander Wyse, Reviewed Work: '''The Life of Joaquim Nabuco'' by Carolina Nabuco' in the journal of The Americas, 1950.)", "pos": "Bertuccio Valiero was the son of Silvestro Valiero and Bianca Priuli.", "neg": "Today, the Eiffel Tower, which serves an important role in television and radio broadcasts, is considered an architectural wonder. It attracts more visitors than any other paid tourist attraction in the world. The Eiffel Tower was designed by the French engineer and bridge builder Alexandre Gustave Eiffel for the Paris Exposition of 1889. The tower is 300 m high and consists of an open iron framework making it the highest manmade structure in the world at the time. It was almost not built. After being awarded the contract to build the tower, Eiffel discovered that the Exposition Committee would only provide about a quarter of the money needed to construct it. Eiffel himself would have to finance the balance. He thought of a deal that would make him a very rich man. He agreed to independently find the people to fund his tower but he wanted to be the only one to control of the tower and he wanted the profits for twenty years. They agreed. To everyone's surprise, including Eiffel, the tower was paid off in the first year. The deal that Eiffel came up with was probably what saved the tower from destruction. A Committee of Three Hundred was formed and they demanded an end to its building. Many members of the committee said, \"They have only put up the framework of this monument, It has no skin.\" Many sculptors and architects protested , in the name of threatened French art and history, about the useless Eiffel Tower, in the heart of their capital. It is built of iron, which is an inferior material, and a single beam of it is unable to support large stresses. That is why the tower appears over-engineered by today's standards. Though, from this very weakness, its simple beauty can be found. If you look at the tower, the structure of it sort of copies the biological cellular structure of a plant.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}357{"query": "The Royal Ballet Sinfonia is the Orchestra of Birmingham Royal Ballet.", "pos": "Chrome Hoof are an experimental chamber rock orchestra based in London, England.", "neg": "In 1977, Hawker Siddeley became a founding component of the nationalised British Aerospace (BAe).", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}358{"query": "Radioactive decay is the breakdown of unstable elements into stable elements. To understand this process, recall that the atoms of all elements contain the particles protons, neutrons, and electrons. An element is defined by the number of protons it contains. All atoms of a given element contain the same number of protons. The number of neutrons in an element may vary. Atoms of an element with different numbers of neutrons are called isotopes. Consider carbon as an example. Two isotopes of carbon are shown in Figure 11.15. Compare their protons and neutrons. Both contain 6 protons. But carbon-12 has 6 neutrons and carbon-14 has 8 neutrons. Almost all carbon atoms are carbon-12. This is a stable isotope of carbon. Only a tiny percentage of carbon atoms are carbon-14. Carbon-14 is unstable. Figure 11.16 shows carbon dioxide, which forms in the atmosphere from carbon-14 and oxygen. Neutrons in cosmic rays strike nitrogen atoms in the atmosphere. The nitrogen forms carbon- 14. Carbon in the atmosphere combines with oxygen to form carbon dioxide. Plants take in carbon dioxide during photosynthesis. In this way, carbon-14 enters food chains. Like other unstable isotopes, carbon-14 breaks down, or decays. For carbon-14 decay, each carbon-14 atom loses an alpha particle. It changes to a stable atom of nitrogen-14. This is illustrated in Figure 11.17. The decay of an unstable isotope to a stable element occurs at a constant rate. This rate is different for each isotope pair. The decay rate is measured in a unit called the half-life. The half-life is the time it takes for half of a given amount of an isotope to decay. For example, the half-life of carbon-14 is 5730 years. Imagine that you start out with 100 grams of carbon-14. In 5730 years, half of it decays. This leaves 50 grams of carbon-14. Over the next 5730 years, half of the remaining amount will decay. Now there are 25 grams of carbon-14. How many grams will there be in another 5730 years? Figure 11.18 graphs the rate of decay of carbon-14. The rate of decay of unstable isotopes can be used to estimate the absolute ages of fossils and rocks. This type of dating is called radiometric dating. The best-known method of radiometric dating is carbon-14 dating. A living thing takes in carbon-14 (along with stable carbon-12). As the carbon-14 decays, it is replaced with more carbon-14. After the organism dies, it stops taking in carbon. That includes carbon-14. The carbon-14 that is in its body continues to decay. So the organism contains less and less carbon-14 as time goes on. We can estimate the amount of carbon-14 that has decayed by measuring the amount of carbon-14 to carbon-12. We know how fast carbon-14 decays. With this information, we can tell how long ago the organism died. Carbon-14 has a relatively short half-life. It decays quickly compared to some other unstable isotopes. So carbon- 14 dating is useful for specimens younger than 50,000 years old. Thats a blink of an eye in geologic time. But radiocarbon dating is very useful for more recent events. One important use of radiocarbon is early human sites. Carbon-14 dating is also limited to the remains of once-living things. To date rocks, scientists use other radioactive isotopes. The isotopes in Table 11.1 are used to date igneous rocks. These isotopes have much longer half-lives than carbon- 14. Because they decay more slowly, they can be used to date much older specimens. Which of these isotopes could be used to date a rock that formed half a million years ago? Unstable Isotope Decays to At a Half-Life of (years) Potassium-40 Uranium-235 Uranium-238 Argon-40 Lead-207 Lead-206 1.3 billion 700 million 4.5 billion Dates Rocks Aged (years old) 100 thousand - 1 billion 1 million - 4.5 billion 1 million - 4.5 billion", "pos": "Radioactive decay is the process in which the nuclei of radioactive atoms emit charged particles and energy, which are called by the general term radiation. Radioactive atoms have unstable nuclei, and when the nuclei emit radiation, they become more stable. Radioactive decay is a nuclearrather than chemicalreaction because it involves only the nuclei of atoms. In a nuclear reaction, one element may change into another. Click image to the left or use the URL below. URL: There are several types of radioactive decay, including alpha, beta, and gamma decay. In all three types, nuclei emit radiation, but the nature of the radiation differs. The Table 1.1 shows the radiation emitted in each type of decay. Type Alpha decay Beta decay Gamma decay Radiation Emitted alpha particle (2 protons and 2 neutrons) + energy beta particle (1 electron or 1 positron) + energy energy (gamma ray) Both alpha and beta decay change the number of protons in an atoms nucleus, thereby changing the atom to a different element. In alpha decay, the nucleus loses two protons. In beta decay, the nucleus either loses a proton or gains a proton. In gamma decay, no change in proton number occurs, so the atom does not become a different element. Q: If the radioactive element polonium (Po) undergoes alpha decay, what element does it become? A: From the periodic table, the atomic number of polonium is 84, so it has 84 protons. If it loses two protons through alpha decay, it will have 82 protons. Atoms with 82 protons are the element lead (Pb). The charged particles and energy emitted during radioactive decay can harm living things, but the three types of radioactive decay arent equally dangerous. Thats because they differ in how far they can travel and what they can penetrate. You can see this in the Figure 1.1.", "neg": "Atoms with unstable nuclei are radioactive. To become more stable, the nuclei undergo radioactive decay. In radioactive decay, the nuclei emit energy and usually particles of matter as well. There are several types of radioactive decay, including alpha, beta, and gamma decay. Energy is emitted in all three types of decay, but only alpha and beta decay also emit particles. Beta decay occurs when an unstable nucleus emits a beta particle and energy. A beta particle is either an electron or a positron. An electron is a negatively charged particle, and a positron is a positively charged electron (or anti- electron). When the beta particle is an electron, the decay is called beta-minus decay. When the beta particle is a positron, the decay is called beta-plus decay. Beta-minus decay occurs when a nucleus has too many neutrons relative to protons, and beta-plus decay occurs when a nucleus has too few neutrons relative to protons. Q: Nuclei contain only protons and neutrons, so how can a nucleus emit an electron in beta-minus decay or a positron in beta-plus decay? A: Beta decay begins with a proton or neutron. You can see how in the Figure 1.1. Q: How does beta decay change an atom to a different element? A: In beta-minus decay an atom gains a proton, and it beta-plus decay it loses a proton. In each case, the atom becomes a different element because it has a different number of protons. Radioactive nuclei and particles are represented by nuclear symbols.. For example, a beta-minus particle (electron) is represented by the symbol 01 e. The subscript -1 represents the particles charge, and the superscript 0 shows that the particle has virtually no mass (no protons or neutrons). Another example is the radioactive nucleus of thorium-234. It is represented by the symbol 234 90 Th, where the subscript 90 stands for the number of protons and the superscript 234 for the number of protons plus neutrons. Nuclear symbols are used to write nuclear equations for radioactive decay. Lets consider the example of the beta- minus decay of thorium-234 to protactinium-234. This reaction is represented by the equation: 234 Th 90 0 234 91 Pa + 1 e + energy The equation shows that thorium-234 becomes protactinium-234 and loses a beta particle and energy. The protactinium- 234 produced in the reaction is also radioactive, so it will decay as well. A nuclear equation is balanced if the total numbers of protons and neutrons are the same on both sides of the arrow. If you compare the subscripts and superscripts on both sides of the equation above, youll see that they are the same. Q: What happens to the electron produced in the reaction above? A: Along with another electron, it can combine with an alpha particle to form a helium atom. An alpha particle, which is emitted during alpha decay, consists of two protons and two neutrons. Q: Try to balance the following nuclear equation for beta-minus decay by filling in the missing subscript and superscript. 131 I 53 ?? Xe + 01 e + energy A: The subscript of Xe is 54, and the superscript is 131. Beta particles can travel about a meter through air. They can pass through a sheet of paper or a layer of cloth but not through a sheet of aluminum or a few centimeters of wood. They can also penetrate the skin and damage underlying tissues. They are even more harmful if they are ingested or inhaled.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}359{"query": "The movie is based on the true story of two British athletes competing in the 1924 Summer Olympics in Paris. Englishman Harold Abrahams (Ben Cross), who is Jewish, overcomes anti-Semitism and class prejudice in order to compete against the \"Flying Scotsman\", Eric Liddell (Ian Charleson), in the 100 metre race.Opening in 1919 England, Harold Abrahams enters Cambridge University, where he meets with anti-Semitism from the staff, but enjoys participating in the Gilbert and Sullivan theatre club. He becomes the first person to ever complete the Trinity Great Court run: running around the court in the time it takes for the clock to strike 12. Abrahams achieves an undefeated string of victories in various national running competitions. Although focused on his running, he falls in love with a famous Gilbert and Sullivan soprano, Sybil (Alice Krige).Meanwhile in Scotland, Eric Liddell (Ian Charleson), born in China of Scottish missionary parents, is in Scotland. His devout sister Jennie (Cheryl Campbell) disapproves of Liddell's plans to pursue competitive running. But Liddell sees running as a way of glorifying God before returning to China to work as a missionary.Abrahams and Liddell meet for the first time in London in June 1923 when they first race against each other in a British open. Liddell beats Abrahams who takes it extremely badly. But Sam Mussabini (Ian Holm), a professional trainer whom Abrahams had approached earlier, offers to take him on to improve his technique. This attracts criticism from the Cambridge college masters (John Gielgud and Lindsay Anderson). In their meeting with Abrahams, the Cambridge masters allege it is ungentlemanly for an amateur to \"play the tradesman\" by employing a professional coach. Abrahams realizes this is a cover for their anti-Semitism and class entitlement, and dismisses their concern.Meanwhile, when Liddell accidentally misses a church prayer meeting because of his running, his sister Jennie upbraids him and accuses him of no longer caring about God. But Eric tells her that though he intends to eventually return to the China mission, he feels divinely inspired when running, and that not to run would be to dishonor God: \"I believe that God made me for a purpose. But He also made me fast, and when I run, I feel His pleasure.\"The two athletes, after over a year of training and racing, are accepted to represent Great Britain in the 1924 Summer Olympics in Paris, France. Also accepted are Abrahams' Cambridge buddies, Lord Andrew Lindsay (Nigel Havers), Aubrey Montague (Nicholas Farrell), and Henry Stallard (Daniel Gerroll) whom join the UK team.While boarding the boat to Paris for the Olympics, Liddell learns from the newspapers that the event for his 100 meter race will be on a Sunday. Liddell refuses to run the race despite strong pressure from the Prince of Wales (David Yelland) as well as the head of the British Olympic committee, Lord Cadogan (Patrick Magee) because Liddell's Christian convictions prevent him from running on the Christian Sabbath (Sunday).Hope appears in the form of Liddell's teammate Lord Andrew Lindsay. Having already won a silver medal in the 400 meter hurdles, Lindsay proposes to yield his place in the 400 meter race on the following Tuesday to Liddell. Liddell gratefully agrees. His religious convictions in the face of national athletic pride make headlines around the world.Liddell delivers a sermon at the Paris Church of Scotland that Sunday, and quotes from Isaiah 40, verse 31:\"But they that wait upon the LORD shall renew their strength; they shall mount up with wings as eagles; they shall run, and be not weary; and they shall walk, and not faint.\"Meanwhile, Abrahams is badly beaten by the heavily favored and more experienced United States runner Charles Paddock (Dennis Christopher) in the 200 meter race who wins the gold medal, while Abrahams takes a second place silver medal. Abrahams knows that his last chance for a gold medal will be the 100 meter run. He competes in the 100 meter sprint and wins, beating Paddock and the rest of the Americans.On Tuesday, just before Liddell's race, the American coach remarks to his runners that Liddell has little chance", "pos": "Set in the Australian outback in the 1880s, the movie follows the series of events following the horrific rape and murder of the Hopkins family, allegedly committed by the infamous Burns brothers gang.The film opens in a brothel during a violent gunfight between the police and Charlie Burns' (Guy Pearce) gang, which ends with the deaths of all of the gang members except for Charlie and his younger brother Mikey. Captain Stanley (Ray Winstone) proposes to Charlie: he and Mikey can go free of the crimes they have committed if Charlie kills his older brother, Arthur (Danny Huston). Arthur is a mercurial psychopath who has become something of a legend and is so vicious that the Aboriginal tribes refer to him as \"The Dog Man\" and both the police and the Aboriginals refuse to go near his camp. Captain Stanley muses that perhaps the bounty hunters will kill Arthur in time and then states his intention to civilize the harsh Australian wilderness by bringing Arthur to justice and using Mikey as leverage. Charlie has nine days to find and kill Arthur, or else Mikey will be hanged from the gallows on Christmas Day.We discover why Captain Stanley is intent on taming Australia: he has been forced to move there with his delicate wife, Martha Stanley (Emily Watson), and apparently wants to make it an appropriate place for them to live. The Stanleys were also friends of the Hopkins family, leading Martha to have nightmares about her dead friends and the unborn child one of them is revealed to have carried. Word spreads of Stanley's deal with Charlie, primarily from Stanley's corrupt subordinate, Sergeant Lawrence (Robert Morgan), causing disgust among the townspeople.Shortly thereafter, Eden Fletcher (David Wenham), for whom Captain Stanley works, orders that Mikey be given one hundred lashes as punishment for the rape and murder of the Hopkins family. Stanley is aghast at this, not only because he believes that Mikey is innocent and the flogging will surely kill him, but because it would also break his deal with Charlie and thus put him and his wife in grave danger. Stanley sends Sergeant Lawrence away with tracker Jacko (David Gulpillil) and other men to \"investigate\" the reported slaying of Dan O'Riley by a group of Aborigines. Captain Stanley attempts to defend Mikey by gunpoint from the bloodthirsty townspeople, but is overruled once Martha arrives, insisting on revenge for her dead friends. Mikey is then brutally flogged, and horrifically wounded. The formerly excited townspeople slowly become disgusted and Martha faints at the ghastly display. After 40 lashes, Mikey has collapsed and the whip is soaked with blood. Captain Stanley grabs the whip and throws it at Fletcher, staining his face and suit with blood, who in turn fires Stanley.Meanwhile, Charlie rides a great distance in search of Arthur, drinking and apparently reflecting on what he will do. Along the way, he encounters an inebriated old man named Jellon Lamb (John Hurt). In the course of conversation, Charlie realizes that Lamb is a bounty hunter in pursuit of the Burns brothers and knocks him out. Later on, after sleeping on a rock bed, Charlie awakes and, before he can gather what's going on, is speared in the chest by a group of Aboriginal men standing over him. Seconds later a gunshot is heard and the head of the man who threw the spear explodes. Charlie then passes out.Charlie wakes up in the camp of his brother Arthur, which is located in caves among desolate mountains. Arthur's gang consists of Samuel Stoat (Tom Budge), who shot the Aboriginal man who had speared Charlie; a woman named Queenie (Leah Purcell) who tends to Charlie's wound; and a muscular Aboriginal man called Two-Bob (Tom E. Lewis). As he recovers from his wounds, Charlie has several opportunities to kill his brother, but does not. Not too far away from Arthur's camp, Sergeant Lawrence and his men have found and butchered a group of Aborigines. Arthur and Two-Bob find Lawrence's group while they sleep, ostensibly to get a horse for Charlie, and proceed to kill Jacko and Sergeant Lawrence. Before Arthur stomps Lawrence", "neg": "Notting hill is a small town west of London. Here lives shy William, a divorced man, who owns a little travel-book store. It was a Wednesday, when the poor shop keeper happened to meet Anna Scott ,a movie star who walked into his shop. They ran across each other in the street again. And they found themselves falling in love. But how could a poor man keep the love of a famous star? Their lives and their worlds were so different. Six months later, Anna was in London again for her new film. She came to William's thought ... Length :110 minutes Director:David Duning Cast:Julia Roberts(actress), Hugh Grant(actor)", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}360{"query": "Built by the Shriners architects Huehl and Schmidt in 1912, the Medinah Temple is a colorful Islamic-looking building replete with pointed domes and an example of Moorish Revival architecture.", "pos": "The Witte Huis (Dutch pronunciation: (t ys)) or White House is a building and National Heritage Site in Rotterdam, Netherlands, built in 1898 in the Art Nouveau style.", "neg": "In 1921, the Corn Palace was rebuilt once again, with a design by the architectural firm Rapp and Rapp of Chicago.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}361{"query": "John Strangways, the British Intelligence (SIS) Station Chief in Jamaica, is ambushed, killed, and his body taken by three assassins known as the \"Three Blind Mice\". In response, MI6 agent James Bond (007) is summoned to the office of his superior, M. Bond is briefed to investigate Strangways' disappearance and to determine whether it is related to his cooperation with the American Central Intelligence Agency (CIA) on a case involving the disruption of Cape Canaveral rocket launches by radio jamming.Upon his arrival at Kingston Airport, a female photographer tries to take Bond's picture and he is shadowed from the airport. He is picked up by a chauffeur, who Bond determines to be an enemy agent. Bond instructs him to leave the main road and, after a brief fight, Bond starts to interrogate the driver, who then kills himself with a cyanide-embedded cigarette.During his investigation Bond sees a picture of a boatman named Quarrel with Strangways. Bond locates Quarrel but finds him to be un-cooperative when he interviews him. Bond also recognises Quarrel to have been the driver of the car that chased him from the airport. Bond follows Quarrel and is about to be beaten by him and a friend when the fight is interrupted by the man from the airport who has been following Bond: he reveals himself to be CIA agent Felix Leiter and that not only are the two agents on the same mission, but also that Quarrel is helping Leiter. The CIA has traced the mysterious radio jamming of American rockets to the Jamaica vicinity, but aerial photography cannot see the exact location of its origin. Quarrel reveals that he has been guiding Strangways around the nearby islands to collect mineral samples. He also tells about the island of Crab Key, owned by the reclusive Dr. No, who operates a bauxite mine which is rigorously protected against trespassers by an armed security force and low-scan radar.After finding a receipt in Strangways' house about mysterious rocks naming, Professor R.J. Dent, Bond meets with Dent who says he had assayed the samples for Strangways and determined them to be ordinary rocks. This visit makes Dent wary and he takes a boat to Crab Key where Dr. No expresses displeasure at Dent's failure to kill Bond and orders him to try again, this time with a large venomous spider. Bond survives and kills the spider.Bond becomes friendly with Strangways' secretary, Miss Taro and agrees to meet her at her home in the hills above Kingston. While driving there, Bond is attacked by several men driving a large hearse. He is able to outmaneuver them and the hearse is run off the mountain road and explodes. When Bond shows up at Taro's house, she's surprised to see him, a fact that Bond notes easily. She goes into her bedroom and talks on the phone to her boss, who tells her to keep Bond occupied for a few hours. Bond and Taro spend that time in bed.Bond makes a phone call, ostensibly asking for a taxi but actually talking to the local police, who show up soon after and arrest Taro. Bond then sets a trap for Dent and waits for him to show. Dent steals into the bedroom and fires several silenced shots into the bed, which Bond rigged to look like it was occupied. Bond forces Dent to drop his pistol and begins to interrogate him about Strangways and his radioactive rock samples, which Dent tried to cover up. Dent is able to recover his pistol, finding it empty and Bond coldly shoots him dead.Having detected radioactive traces in Quarrel's boat, where Strangways' mineral samples had been, Bond convinces a reluctant Quarrel to take him to Crab Key. On the beach there, Bond meets the beautiful Honey Ryder, dressed only in a white bikini, who is collecting shells. At first she is suspicious of Bond but soon decides to help him, leading them all inland to an open swamp. After nightfall they are attacked by the legendary \"dragon\" of Crab Key which turns out to be a flame-throwing armoured vehicle. In the resulting gun battle, Quarrel is incinerated by the flame-thrower whilst Bond and Honey are", "pos": "The film starts with a brief recollection of the \"Killing Angel\", a dangerous assassin that has been operating in most of southeast Asia. The Killing Angel has no known accomplices or colleagues, is not affiliated with any government, religious, or criminal organization, and to this date their true identity has still remained secret. The Killing Angel is believed to be responsible for 6 murders in the past year alone, with only one thing connecting each of the assassinations - all the victims were criminals and deserved to die.Then the movie quickly moves on to the Killing Angel's most recent killing, the well-publicized assassination of a notorious ex-yakuza crime boss. Working swiftly, the Killing Angel is able to overcome the criminal's defense systems, quickly incapacitating the boss's bodyguards and isolating his target. In a fit of desperation, the crime boss promises to triple whatever fee the Killing Angel is being paid to kill him, then goes on to warn the vigilante that there is a massive revenge fund set to avenge his killing. Ignoring his pleas, the Killing Angel silently kills the crime boss.The scene then switches over to the story of Fu (Jet Li), a small-town gang member who lives an extremely simple and modest lifestyle, albeit being a contract killer. It is revealed that Fu is very kind and has trouble killing innocent people, a trait that causes him to be disliked by the other low-rent triad members. When Fu's boss reveals that there is now a $100 million US bounty on the Killing Angel's head for the slaying of the yakuza boss, Fu is quick to volunteer for the job, but is instead insulted.Fu then attempts to enter the building where the crime boss's lawyers are discussing the terms for the revenge fund, but is detained at the entrance and ushered out by security guards. In a surprisingly quick sequence, Fu defends himself by rapidly incapacitating each of the guards. His lightning-swift martial arts skills draw the attention of Ngok Lo, played by Eric Tsang, a seedy contract booker and loan shark, who comes to Fu's aid by pretending that he is an agent and Fu is his actor. Thanks to Lo's smooth talking, the pair is able to sidle into the meeting.The meeting however, comes to a halt when government agents, led by detective Chan (Simon Yam), raid the building in search of known criminals who are meeting there. Chan, a leading detective, has been working tirelessly to expose the Killing Angel's true identity for years. The movie then switches over to another sequence, where the character of Eiji Tsukamoto, the slain crime boss's grandson, played by Renji Sato, is introduced. Tsukamoto, fed up with his grandfather's cowardice in life, now seeks his grandfather's power in death. Tsukamoto consumes a portion of his grandfather's cremated ashes, an act that causes the deceased lord's top aid to call him insane, but now all of the family's agents and gang members serve Tsukamoto as their new master.Fu and Lo get to know each other - Fu is an ex-soldier from mainland China, part of a special, world-famous unit known as the \"Golden Soldiers\". When Lo asks for a demonstration of Fu's skills, he is able to rapidly take down several ruffians simultaneously, but falters when he is confronted by a woman. Lo then explains the deal with Fu, and they head for an amusement park to assassinate the first person believed to be the Killing Angel. However, when they get there, it is revealed their target is a simple family man, and instead of killing him, Fu saves his life by killing his other assassins, the low-rank triad members he formerly lived with.Fu and Lo are then arrested, but they are bailed out by Lo's daughter, Kiki (Gigi Leung), an intelligent and successful lawyer fed up with her father's scandalous ways and criminal connections. Fu moves in with Lo now that he has no place to stay, and they quickly become friends, Lo claiming he used to be an infamous hitman known", "neg": "Jonathan Shale (Berenger) is a mercenary and a Vietnam veteran who returns home to Miami after a botched covert operation in Cuba in which three men from his platoon were killed. He surprises his girlfriend, Jane Hetzko (Diane Venora) at her apartment and is warmly welcomed. On the outside, Jane is a schoolteacher at inner-city Columbus High School, an institution with a considerable gang problem. She is particularly disliked by Juan Lacas (Anthony), leader of the KOD (\"Kings of Destruction\") gang. While jogging one morning, Jane is attacked and has her leg broken. Jane and Shale believe this to be related to the KOD, which prompts the latter to go undercover as an Ivy League-educated, government-affiliated substitute teacher for his girlfriend's class. Shale arrives at Columbus High School and is, at first, taken back by the lowly conditions. He is unable to control his class of poorly-educated students on the first day, but decides to use his street-smarts and military tactics to gain the upper hand. Soon enough, he is able to take command of the students by displaying his combat self-defence techniques when students attack him. He is warned not to use such methods by Principal Claude Rolle (Hudson), but gains the respect of his students when he bonds with them over the similarities between his early gang and Vietnam War experiences and their involvement in petty crime and street gangs. During this time, he befriends fellow schoolteacher Darrell Sherman (Plummer) and also crosses paths with Lacas, one of his students. Suspicious of odd conditions within the high school, Shale sets up surveillance cameras throughout the building. He discovers that Lacas orchestrated the attack on Jane. He also discovers that Lacas is secretly working with Rolle to distribute cocaine around Miami for a major narcotics ring. Shale and his team raid a drug deal, using the stolen money to buy music and sports equipment in the form of a \"school donation.\" While Sherman initially denies Shale's discovery, Sherman and a female student inadvertently witness the drugs being loaded into one of the school buses later that day. Sherman tells the student to warn Shale and Hetzko, and sacrifices himself by creating a distraction. Rolle, who at this point is aware of Shale's interference orders a \"car accident\" for Shale, and sends Lacas after Hetzko. With the help of another student, Lacas is killed and Shale saves Hetzko, learning the full story from the female witness. Shale and his team garrison the school grounds to enter combat against the remaining K.O.D. members, a rival mercenary company led by Janus, and Rolle himself. Ultimately, Shale and Joey Six end up as the sole survivors of the battle, walking away from the school grounds discussing future operations as substitute teachers.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}362{"query": "The Eastern Columbia Building, also known as the Eastern Columbia Lofts, is a thirteen-story Claud Beelman designed Art Deco building located at 849 S. Broadway in the Broadway Theater District of Downtown Los Angeles.", "pos": "Edificio La Nacional is an Art Deco office building located in Avenida Juarez, in the Historical Centre of Mexico City, just across the street from Palacio de Bellas Artes.The building's architect was Manuel Ortiz Monasterio.", "neg": "Dr. Adder is an artist-surgeon, who modifies sexual organs of his patients to satisfy the weirdest of perversion; he is clearly depicted as a partly criminal, partly counter-cultural figure in a future Los Angeles which anticipates the cyberpunk idea of the Sprawl.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}363{"query": "In 278 BC, learning of the capture of his country's capital, Ying, by General Bai Qi of the state of Qin, Qu Yuan is said to have written the lengthy poem of lamentation called ''Lament for Ying'' and later to have waded into the Miluo river in today's Hunan Province holding a rock in order to commit ritual suicide as a form of protest against the corruption of the era.", "pos": "Xu Jingzong subsequently sent the official Yuan Gongyu () to force Zhangsun Wuji to commit suicide on his way to exile.", "neg": "Terra-cotta Warriors As the greatest archaeological findings of the 20th century, Terra-cotta Warriors has a really long history.In 246 BC, Qin Shi Huang, later the first Emperor of all China, had begun to prepare for his mausoleum which took 11 years to finish to defend him in the afterlife.There are over 7,000 pottery soldiers, horses, bronze chariots, and even weapons found in it now.Terra-cotta Warriors was listed by UNESCO in 1987 as one of the world cultural heritages and it has made Xi'an a famous city for tourists. Big Wild Goose Pagoda The Big Wild Goose Pagoda has a history of over 1,300 years and is a typical ancient Chinese building.It is located in the south of Xi'an City.Because Master Xuanzang stored his classics brought from India in the pagoda, it is also a holy place for Buddhists.As a National Key Cultural Relic Preserve, it won the title of an AAAA Tourist Attraction as well. Xi'an Ancient City Wall As one of the landmarks of Xi'an, Ancient City Wall still stretches round the old city today, dividing the city into the inner part and the outer part.Ancient City Wall was originally built during the old Tang Dynasty (618 -- 907) and then enlarged by Zhu Yuanzhang, Emperor of the Ming Dynasty, thus forming the modern Xi'an City Wall.After the extension, the wall now stands 12 meters tall, 12-14 meters wide at the top and 15-18 meters thick at the bottom.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}364{"query": "Presently the Appalachian elktoe is considered critically endangered, and it is unknown if they are still in fact actively reproducing.", "pos": "The European eel is a critically endangered species.", "neg": "Language Matters with Bob Holman is a 2015 documentary which focuses upon the rapid extinction of many of planet Earth's human languages and the multifarious struggles and efforts to save and preserve them.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}365{"query": "The House with Laughing Windows (Italian title: La casa dalle finestre che ridono) is a 1976 Italian giallo film co-written and directed by Pupi Avati.", "pos": "Bianchi cavalli d'Agosto (internationally known as White Horses of Summer) is a 1975 Italian drama film written and directed by Raimondo Del Balzo.", "neg": "Parameria (common name naranjo podrido) is a genus of flowering plants in the dogbane family, Apocynaceae, first described as a genus in 1876.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}366{"query": "Trends come and go but style is eternal. So what is the latest fashion trend that defines this season? Let's take a look at the fashion trend in 2016 and be the first ones to embrace the latest trend. Head----It seems like everyone will be wearing a bucket hat this season. Bucket hat might sound a bit old-fashioned for some people, but the 90s trend is in season again! Spring and summer are always the seasons for casual clothes, so pairing the bucket hat with casual shorts or skirts would be your outfit to go in this spring and summer in 2016. Bottom--Summer is the season when everyone gets ready for the humid weather. The current season trend is making everyone have a more comfortable summer because wide-leg bottoms is in trend again. Perhaps not everyone likes wide-leg bottoms because this could possible make people look shorter, choosing a high-waist wide-leg bottom and matching it with crop top will definitely make you look taller and trendy in 2016. Dress---Be prepared for embracing the feminine details this season. Ruffles around the sleeve or ruffles all-over the dress will be everyone's favorite in SS 2016. All these little details will transform your look in season. Simple colors like pink and black are designer's favorites in this season too. Shoes---Many people thought wedges are also the shoes to go in spring and summer time, but in SS 2016, very flat flats are in trend again. Shoe designers are trying to have more combinations flats or low-heels with less of gender identity. Accessories----No outfit goes perfect without accessories. Adding statement accessories to your simple and natural outlook this summer is your day-to-night outfit. These jewels are doing to make you feel completed in day time and sparkled at night.", "pos": "While most teachers enjoy the summer break from work, other teachers try to find part-time work during that time. If you're one of those teachers who are finding part-time work during the summer, writing for children might be the right job you're looking for. During the school year, you're very familiar with children in your classroom. That means you know what children think about, how they talk and how they act. If you read stories and books for children with your students during the school year, you also know the kinds of story that children are fond of. As a teacher, you can go to the school library and find out what kinds of books students are most interested in. Also, what kinds of books seem to be in short supply? Use this information to create stories and novels. If you continue writing for children during the school year, you won't have enough time to write as much while you're teaching, but you can probably manage to work on at least one short story for children each month. Even if you don't finish these pieces during the school year, when school ends for the summer you will have lots of writing projects to finish and hand in to editors . Recently, many teachers have turned to writing for children as a part-time job. If you enjoy writing as much as you enjoy teaching, then writing for children might be the second job for you, too.", "neg": "This article's plot summary may be too long or excessively detailed. Please help improve it by removing unnecessary details and making it more concise. (August 2015) (Learn how and when to remove this template message) Edna Buxton (Illeana Douglas) is a steel heiress from Chestnut Hill, Philadelphia, who wants to be a singer and enters a talent contest. The story begins with a conversation between herself and her mother (Christina Pickles) with regard to what she will sing and what she will wear. At her mother's insistence, she reluctantly makes a plan to sing \"You'll Never Walk Alone.\" Edna is even less thrilled about her mother's choice of wardrobe, calling it uncomfortable. Her mother responds with a cutting remark, \"Perhaps it's not the dress. Perhaps it's you who doesn't fit, dear.\" Backstage at the contest, she meets a blues singer named Doris Shelley (Jennifer Leigh Warren). Doris advises Edna to follow her heart, and the two women trade dresses. Clad in Doris's sleek black dress, Edna sings \"Hey There\" instead. Despite the fact that she wins the contest, she loses the respect of her mother, who has since left the theater in humiliation. An excited Denise decides to use her grand prize winnings to record a demo. The studio producer (Richard Schiff) tactfully delivers the painful truth to Edna that not only are girl singers not getting signed, the record companies are trying to get rid of the ones currently on their rosters. When she tells him that she wrote the song, he is impressed enough to direct her to Joel Milner (John Turturro) who takes her under his wing, renames her \"Denise Waverly\" and invents a blue-collar persona for her. Milner reworks her song for a male doo-wop group, the Stylettes, as male solo artists are groups are far more marketable. The song becomes a hit. Denise moves to New York and becomes a songwriter in the Brill Building. At a party, she meets the arrogant songwriter Howard Caszatt (Eric Stoltz), and despite an awkward initial meeting they become romantically involved. She also reunites with Doris, who is not only singing at the party that night, but apologizes for keeping Denise's expensive dress after all that time. She insists it was because she wasn't sure how or where to return it. Meanwhile, Denise offers to and writes a song specifically for Doris and her two girlfriends. She persuades a reluctant Milner to audition the group. Milner likes the group and the song Denise has written, and renames the group The Luminaries. At Howard's insistence he and Denise begin writing together; partly out of respect for her talent, but primarily because she's had greater mainstream and commercial success. His songs had been deemed \"too controversial\" and had been repeatedly banned from radio airplay. She overhears an argument between Sha-Sha (Kathy Barbour)'s niece Annie (Tracy Vilar) and her boyfriend. It turns out the young teen is pregnant. Denise and Howard pen the song \"Unwanted Number\" based on the girl's struggle. Although it's banned, it attracts the attention of prominent and influential disc jockey John Murray (Bruce Davison) who, despite the negative attention of the song, credits Denise with sparking the craze for girl groups. Denise then suggests that she and Howard should write a wedding-themed song for the Luminaries. Howard says he doesn't believe in marriage, but when Denise reveals that she is pregnant with Howard's child, they are married and have a daughter. Life is idyllic for Denise with a family and successful songwriting career. Milner then recruits the beautiful English songwriter Cheryl Steed, who immediately catches Howard's eye, and ultimately Denise's disdain. Cheryl immediately diffuses the flirtation by informing the couple that she already has a songwriting partnerher husband Matthew (Chris Isaak). Joel tasks Denise and Cheryl with collaboration on a song for the ingenue singer Kelly Porter (Bridget Fonda). The women protest but, nevertheless, bond over the realization that the young songstress is in a closeted lesbian relationship. Their song \"My Secret Love\"", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}367{"query": "Stephen Crain is the Director of the ARC Centre of Excellence in Cognition and its Disorders (CCD), and a Distinguished Professor at Macquarie University in the Department of Linguistics.", "pos": "Stephen L. Golding (born 1944) is an emeritus professor of psychology at the University of Utah and a forensic psychologist who has written a large amount of articles on the process of determining whether people are competent to stand trial.", "neg": "Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary cerebrovascular disease leading to accumulating neurologic deficits and dementia. CADASIL has been linked to nucleotide substitutions and deletions in the Notch3 gene. All the mutations described until now lead to unpaired cysteine residue in the epidermal growth factor-like repeats. The authors report a family with CADASIL carrying a deletion in the Notch3 gene that did not involve a cysteine residue.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}368{"query": "\"Since the dawn of what became a legend, the most unimaginable is about to occur . This summer, experience the absolute conquest of all mankind. Beginning with one search. For the one and only. The chosen one. Descended from the heavens above. Welcome to Dragon Wars.\"A STORY THAT HAS BEEN LOST TO MANKIND...CONCEPT:\"Dragons are mythical, legendary creatures found in cultures throughout the world. However, the Imoogi possesses extraordinary powers that allow it to transform itself into a dynamic, powerful and sometimes demonic animal.In mythology, the Dragon is characterized as a divine governor of water and rain. People held sacrificial rites to the God of King Dragon to pray for rain or protection from deadly storms . These sacrificial rites also included prayers to the Imoogi because it had the ability to cause droughts by filling the skies with fire. There are still actual remnants around the cult-like shrines and prayer altars used to worship the Imoogi thousands of years ago.Yeouijoo, a symbol for Dragon, refers to a magical pearl possessing the power to grant any wish. Legend has it that an Imoogi can transform itself into a Dragon if it acquires the Yeouijoo .Every five hundred years, the Imoogi have the ability to become Dragons and, thereby, conquer the world by obtaining the magical Yeouijoo.The Yeouijoo is currently hidden in a young's girl's body. The culmination of the Imoogi's perseverance and determination promises to bring dramatic, devastating and inconceivable consequences .By applying the legend of Imoogi to modern times, D-War is a film that invites us into a new and exceptional world full of suspense, thrill and fantasy !SYNOPSIS:In a small Korean village, five hundred years ago, a girl named Narin was born carrying the coveted Yeouijoo inside her. The Heavens sent the protector Bochun and his protege Haram, to ensure that when it came time, Narin was peacefully sacrificed to the pre-determined Good Imoogi. Bochun vigorously trained Haram as a knight, to be prepared for the eventual day when Narin would be delivered to the Good Imoogi. The day the Dark Imoogi, Buraki, and his army destroyed Narin's village looking for the Yeouijoo, Bochun instructed Haram to take her to the Good Imoogi.The young girl and her knight would then fulfill the giant's serpent's destiny by giving it the power to save the world and become a heavenly dragon. By this time, after spending several years together, Haram and Narin had fallen in love. Unable to sacrifice their love to the benevolent Imoogi, they jumped to their deaths together in each other's arms. The Good Imoogi's destiny was unfulfilled and he would have to wait another five hundred years until the next Yeouijoo appears.It is now five hundred years later in present day Los Angeles and the quest for the Imoogi is reborn. Haram and Narin have been reincarnated as Ethan Kendrick and Sarah Daniels whose bond of love remains unsevered. Ethan is an investigative reporter for the local news. He is closely following a series of unexplainable disasters occurring in the area. When a young woman named Sarah is linked to those occurrences, Ethan remembers that an ancient man he met many years before had predicted all of these events . Ethan finds Sarah and helps her escape the wrath of Buraki and his army. Aware that Sarah must sacrifice herself in order to save the city from the Buraki and ensure that the Good Imoogi becomes the Dragon, Ethan tries to convince Sarah that there is another way to battle the Imoogies. Meanwhile, the FBI agent on the case, Frank Campbell, has uncovered the Imoogies' intentions through his own investigations. Campbell is ready to sacrifice Sarah to the demonic animals to save Los Angeles. In the face of chaos and destruction, Ethan and Sarah must decide their own fate - whether to defy the will of heaven once again and let the city be destroyed or deliver Sarah to the Good Imoogi. \"-----end( obtained from Younggu-Art by media liaison, Irene Nakano , in Seoul , Korea / e-mail: soongshil@gmail.com )", "pos": "\"Legend tells of a legendary warrior whose kung fu skills were the stuff of legend...\" A mysterious panda donning a flowing cape and sedge hat walks through the Chinese landscape. Reputed to be a grand master of kung fu, he enters a tavern where he is immediately attacked by the local ruffians. However, they are no match for his skill and even the legendary kung fu masters, the Furious Five, bow down to the panda's skill, requesting to hang out with him and fight alongside him as......Po the giant panda (Jack Black) wakes up from his dream in his room. His goose father, Mr. Ping (James Hong) calls to him from the noodle restaurant below to help serve tables. Po admires his Furious Five action figures before going downstairs. An extreme fan of Kung Fu, Po dreams of one day becoming a master worthy of fighting alongside the Five but his girth and clumsiness makes this dream simply a dream and his kung fu talents reside only within his knowledge of moves and artifacts. He is hesitant to express his desires to his dad who is more interested in running his restaurant and advertising his famous 'secret ingredient soup'.Master Shifu (Dustin Hoffman), a red panda who resides at the Jade Palace temple, practices kung fu in the courtyard with his students, the Furious Five; Tigress (Angelina Jolie), Crane (David Cross), Monkey (Jackie Chan), Viper (Lucy Liu), and Mantis (Seth Rogen), before he is summoned to see tortoise Grand Master Oogway (Randall Duk Kim). Fearing something is wrong, Shifu rushes to find him meditating in the grand hall. Oogway doesn't deny bad news but calmly tells Shifu he's predicted that the snow leopard warrior Tai Lung (Ian McShane) will escape prison and return to the Valley of Peace to wreak destruction once again. Intent on never letting this happen, Shifu sends his goose messenger, Zeng (Dan Fogler), to fly to Chor-Gom Prison to ensure that security is increased. Oogway then proclaims that it is time to choose the Dragon Warrior; a master of great skill who will be granted the secrets of the universe by reading the Dragon Scroll, kept delicately out of reach on the temple ceiling. Assuming that one of the Furious Five will be chosen, Shifu prepares a competition to determine which one will qualify.Flyers for the competition are spread throughout town and the villagers flock to the temple. Excited to have the opportunity to see his idols in person, Po follows with his noodle cart in tow but struggles on the long staircase to the temple. He is the last to arrive at the gates and finds that they've shut him out. In a desperate bid to see the competition before it's over, Po fashions fireworks to his cart and blasts himself high into the air, only to come crashing down in the arena just as Oogway is preparing to choose out of the Five. Po opens his eyes to see Oogway's finger pointed right at him and is shocked, along with everyone else, when he is proclaimed to be the Dragon Warrior. Oogway's decision is final, despite Shifu's protests, and Po is carried (unsuccessfully) into the temple leaving Tigress greatly disappointed since it seemed Oogway would have chosen her if Po hadn't arrived.Inside the temple, Po examines, with awe, the many weaponry and valuable artifacts before Shifu approaches him and berates him for his obvious lack of skill. He deflates Po's excitement by grabbing his finger in what Po recognizes as the Wuxi Finger Hold, reputed to be extremely powerful. Shifu promises that Po will regret ever being chosen before taking him to the Fives training room where Po is promptly put to the test. Nervous, but excited to try some kung fu moves, Po accepts the challenge but is hurtled, flung, and beaten down to a now-existing Level 0.On the way to the dormitories, Po overhears the Five poke fun at his incompetence. He has an awkward conversation with Crane, opening up to his own doubts of being the Dragon Warrior. Tigress assures his doubts, calling him a disgrace to kung fu and tells", "neg": "A Viking boy called Hiccup (voice: Jay Baruchel) introduces his village of Berk (\"it's been here for seven generations, but every single building is new\"). The village is attacked by dragons, who steal food (mostly sheep) and set things on fire (hence all the new buildings). The villagers grab weapons and try to fight the dragons off. Despite being told by every adult in sight to go indoors, Hiccup hauls out a bolas-shooting cannon he made himself and shoots a dragon out of the night sky. (As assistant to the village blacksmith, Gobber (voice: Craig Ferguson), Hiccup has access to tools and materials and knows how to use them.) The dragon lands in the woods some distance form the village and no one believes that he hit anything, so it's the next day before Hiccup can go looking for it. It turns out to be a rare and deadly Night Fury, but Hiccup can't make himself kill it. Instead he releases it -- whereupon it also refrains from killing Hiccup -- and it flies off through the trees.Hiccup discovers that the dragon (which he eventually calls Toothless because of its retractable teeth) has holed up in a steep-sided valley because it can no longer fly more than a few feet at a time. While sketching the dragon, Hiccup realizes that it's missing a tail fin. He makes a prosthetic tail fin out of leather. The new fin helps, but Toothless can't control it and inadvertently takes Hiccup for a ride, giving him a clear idea of what's needed to help the dragon fly right. In a series of workshop and test flight scenes, Hiccup builds and perfects a saddle, a control mechanism for the tail fin, and a safety harness.Meanwhile, Hiccup's father Stoick (voice: Gerard Butler) has signed him up for dragon training with Gobber, which is very different from the training he's already doing with Toothless: he's going to learn to fight dragons. At first, he's the worst student in the class. Since Hiccup has always been an accident-prone klutz, this comes as no surprise to his classmates Astrid (voice: America Ferrera), Snotlout (voice: Jonah Hill), Fishlegs (voice: Christopher Mintz-Plasse), Ruffnut (voice: Kristen Wiig), and her twin brother Tuffnut (voice: T.J. Miller). (Hiccup's a little sweet on Astrid.) Before long, Hiccup is able to use some things he's learned while working with Toothless to soothe and manage the school's practice dragons. (It turns out dragons are just big kitty-cats: they like to be petted, there's a kind of grass that's like cat-nip to them, and they love fish (but hate eels).) When Stoick returns from a failed search for the fabled nest of the dragons, he's surprised but thrilled to hear that his son is doing brilliantly at dragon training. He gives Hiccup a horned helmet made from one of his dead mother's breastplates. But Hiccup, as usual, is unable to get around his father's expectations and speak frankly, so he can't explain that his success at dragon school is unlikely to lead to the slaying of any dragons.When Hiccup subdues a practice dragon, unintentionally earning the privilege of killing it before the entire village, he's horrified and decides to flee with Toothless. However Astrid, having noticed Hiccup's frequent disappearances and secretive behavior, is suspicious. She follows him to the hidden valley and sees Toothless. Unable to explain his relationship with the dragon, Hiccup takes her flying, and she's captivated. But they get caught up in a flock of dragons returning to their nest carrying food. The dragons fly inside a mountainous island and drop the food into a pit, which turns out to contain a huge, terrifying, and very hungry dragon that eats the smaller ones if they don't bring it enough food. Hiccup and Astrid and shocked to realize that the dragons have been stealing their sheep to keep from being eaten themselves. When they get home,", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}369{"query": "Vitamins and minerals are also nutrients. They do not provide energy, but they are needed for good health. Vitamins are organic compounds that the body needs in small amounts to function properly. Humans need 13 different vitamins. Some of them are listed below ( Table 1.1). The table also shows how much of each vitamin you need every day. Vitamins have many roles in the body. For example, Vitamin A helps maintain good vision. Vitamin B9 helps form red blood cells. Vitamin K is needed for blood to clot when you have a cut or other wound. Vitamin Necessary for Available from Daily Amount Required (at ages 913 years) Vitamin Necessary for Available from A Good vision B1 Healthy nerves B3 Healthy skin and nerves B9 Red blood cells B12 Healthy nerves C Growth and repair of tis- sues Healthy bones and teeth Blood to clot Carrots, spinach, milk, eggs Whole wheat, peas, meat, beans, fish, peanuts Beets, liver, pork, turkey, fish, peanuts Liver, peas, dried beans, leafy green vegetables Meat, liver, milk, shell- fish, eggs Oranges, grapefruits, red peppers, broccoli Milk, salmon, tuna, eggs Spinach, brussels sprouts, milk, eggs D K Daily Amount Required (at ages 913 years) 600 g (1 g = 1 106 g) 0.9 mg (1 mg = 1 103 g) 12 mg 300 g 1.8 g 45 mg 5 g 60 g Some vitamins are produced in the body. For example, vitamin D is made in the skin when it is exposed to sunlight. Vitamins B12 and K are produced by bacteria that normally live inside the body. Most other vitamins must come from foods. Foods that are good sources of vitamins include whole grains, vegetables, fruits, and milk ( Table 1.1). Not getting enough vitamins can cause health problems. For example, too little vitamin C causes a disease called scurvy. People with scurvy have bleeding gums, nosebleeds, and other symptoms. Minerals are chemical elements that are needed for body processes. Minerals that you need in relatively large amounts are listed below ( Table 1.2). Minerals that you need in smaller amounts include iodine, iron, and zinc. Minerals have many important roles in the body. For example, calcium and phosphorus are needed for strong bones and teeth. Potassium and sodium are needed for muscles and nerves to work normally. Mineral Necessary for Available from Calcium Strong bones and teeth Chloride Magnesium Proper balance of water and salts in body Strong bones Phosphorus Strong bones and teeth Potassium Muscles and nerves to work normally Muscles and nerves to work normally Milk, soy milk, leafy green vegetables Table salt, most packaged foods Whole grains, leafy green vegetables, nuts Meat, poultry, whole grains Meats, grains, bananas, orange juice Table salt, most packaged foods Sodium Daily Amount Required (at ages 913 years) 1,300 mg 2.3 g 240 mg 1,250 mg 4.5 g 1.5 g Your body cannot produce any of the minerals that it needs. Instead, you must get minerals from the foods you eat. Good sources of minerals include milk, leafy green vegetables, and whole grains ( Table 1.2). Not getting enough minerals can cause health problems. For example, too little calcium may cause osteoporosis. This is a disease in which bones become soft and break easily. Getting too much of some minerals can also cause health problems. Many people get too much sodium. Sodium is added to most packaged foods. People often add more sodium to their food by using table salt. Too much sodium causes high blood pressure in some people.", "pos": "Did you know that blood is a tissue? Blood is a fluid connective tissue that is made up of red blood cells, white blood cells, platelets, and plasma. The cells that make up blood are pictured below ( Figure 1.1). The different parts of blood have different roles. A scanning electron microscope (SEM) image of human blood cells. Red blood cells are the flat, bowl-shaped cells, the tiny disc-shaped pieces are platelets, and white blood cells are the round cells shown in the center. If you were to filter out all the cells in blood, a golden-yellow liquid would be left behind. Plasma is this fluid part of the blood. Plasma is about 90% water and about 10% dissolved proteins, glucose, ions, hormones, and gases. Blood is made up mostly of plasma. Red blood cells (RBCs) are flattened, disk-shaped cells that carry oxygen. They are the most common blood cell in the blood. There are about 4 to 6 million RBCs per cubic millimeter of blood. Each RBC has about 200 million molecules of hemoglobin. Hemoglobin is the protein that carries oxygen. Hemoglobin also gives the red blood cells their red color. Red blood cells ( Figure 1.2) are made in the red marrow of long bones, rib bones, the skull, and vertebrae. Each red blood cell lives for only 120 days (about four months). After this time, they are destroyed in the liver and spleen. Mature red blood cells do not have a nucleus or other organelles. Lacking these components allows the cells to have more hemoglobin and carry more oxygen. The flattened shape of red blood cells helps them carry more oxygen than if they were rounded. White blood cells (WBCs) are usually larger than red blood cells. They do not have hemoglobin and do not carry oxygen. White blood cells make up less than one percent of the bloods volume. Most WBCs are made in the bone marrow, and some mature in the lymphatic system. There are different WBCs with different jobs. WBCs defend the body against infection by bacteria, viruses, and other pathogens. WBCs do have a nucleus and other organelles. Neutrophils are WBCs that can squeeze through capillary walls and swallow particles such as bacteria and parasites. Macrophages are large WBCs that can also swallow and destroy old and dying cells, bacteria, or viruses. Below, a macrophage is attacking and swallowing two particles, possibly disease-causing pathogens ( Figure Lymphocytes are WBCs that fight infections caused by viruses and bacteria. Some lymphocytes attack and kill cancer cells. Lymphocytes called B-cells make antibodies. A type of white blood cell, called a macrophage, is attacking a cancer cell. Platelets ( Figure 1.4) are very small, but they are very important in blood clotting. Platelets are not cells. They are sticky little pieces of larger cells. Platelets bud off large cells that stay in the bone marrow. When a blood vessel gets cut, platelets stick to the injured areas. They release chemicals called clotting factors, which cause proteins to form over the wound. This web of proteins catches red blood cells and forms a clot. This clot stops more blood from leaving the body through the cut blood vessel. The clot also stops bacteria from entering the body. Platelets survive in the blood for ten days before they are removed by the liver and spleen.", "neg": "The Centers for Disease Control and Prevention (CDC) recently announced trends in fruit and vegetable consumption among adults. Since 2000, the CDC has made efforts with goals of getting 75% of Americans to eat two or more servings of fruit a day and 50% of Americans to eat three or more servings of vegetables a day. Unfortunately, Americans aren't meeting these modest targets. Although a diet high in fruit and vegetables can reduce the risk of many diseases, Americans just aren't getting enough. In fact, since 2000, the amount of vegetables Americans are eating has stayed the same and the amount of fruit Americans are eating has gone down. The CDC also finds that only about a third of adults are eating their expected servings of fruit, and just over a quarter of adults are eating their expected servings of vegetables. So why aren't Americans getting their expected servings of fruit and vegetables? It turns out that Americans might be spoiled when it comes to their produce. A national survey conducted by Fruit2day reveals that nearly half of Americans leave fruit in their fridges until it rots with people in Boston among the worst and those in New York and Los Angeles among the best. Sadly, most Americans admit to leaving fruit in the fridge for more than a week. There are many reasons why Americans don't eat their fruit or vegetables, including the inconvenience of having to wash or peel it. Fruit2day offers consumers a surprising and convenient way to enjoy the goodness of fruit. \"With no added sugar, natural juices and two full servings of fruit, our Fruit2day line has really captured the imaginations of health-conscious consumers who are actively looking to get more fruit in their diets,\" said Hanno Holm, president and chief executive officer of Hero-White Wave. \"Fruit2day makes getting more fruit in one's diet easier for any daily snack routine.\"", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}370{"query": "Earths outer surface is its crust, a cold, thin, brittle outer shell made of rock. The crust is very thin relative to the radius of the planet. There are two very different types of crust, each with its own distinctive physical and chemical properties, which are summarized in Table 1.1. Crust Oceanic Continental Thickness 5-12 km (3-8 mi) Avg. 35 km (22 mi) Density 3.0 g/cm3 2.7 g/cm3 Composition Mafic Felsic Rock types Basalt and gabbro All types Oceanic crust is composed of mafic magma that erupts on the seafloor to create basalt lava flows or cools deeper down to create the intrusive igneous rock gabbro (Figure 1.1). Gabbro from ocean crust. The gabbro is deformed because of intense faulting at the eruption site. Sediments, primarily mud and the shells of tiny sea creatures, coat the seafloor. Sediment is thickest near the shore, where it comes off the continents in rivers and on wind currents. The oceanic crust is relatively thin and lies above the mantle. The cross section of oceanic crust in the Figure 1.2 shows the layers that grade from sediments at the top to extrusive basalt lava, to the sheeted dikes that feed lava to the surface, to deeper intrusive gabbro, and finally to the mantle. Continental crust is made up of many different types of igneous, metamorphic, and sedimentary rocks. The average composition is granite, which is much less dense than the mafic rocks of the oceanic crust (Figure 1.3). Because it is thick and has relatively low density, continental crust rises higher on the mantle than oceanic crust, which sinks into the mantle to form basins. When filled with water, these basins form the planets oceans. Click image to the left or use the URL below. URL: A cross-section of oceanic crust.", "pos": "The layers scientists recognize are pictured below (Figure 1.1). Core, mantle, and crust are divisions based on composition: 1. The crust is less than 1% of Earth by mass. The two types are oceanic crust and continental crust.Continental crust is felsic and oceanic crust is mafic. 2. The mantle is hot, ultramafic rock. It represents about 68% of Earths mass. 3. The core is mostly iron metal. The core makes up about 31% of the Earth. Lithosphere and asthenosphere are divisions based on mechanical properties: 1. The lithosphere is composed of both the crust and the portion of the upper mantle and behaves as a brittle, rigid solid. 2. The asthenosphere is partially molten upper mantle material and behaves plastically and can flow. A cross section of Earth showing the fol- lowing layers: (1) crust (2) mantle (3a) outer core (3b) inner core (4) lithosphere (5) asthenosphere (6) outer core (7) inner core. Click image to the left or use the URL below. URL: Click image to the left or use the URL below. URL:", "neg": "A rock under enough stress will fracture. There may or may not be movement along the fracture. If there is no movement on either side of a fracture, the fracture is called a joint. The rocks below show horizontal and vertical jointing. These joints formed when the confining stress was removed from the rocks as shown in (Figure If the blocks of rock on one or both sides of a fracture move, the fracture is called a fault (Figure 1.2). Stresses along faults cause rocks to break and move suddenly. The energy released is an earthquake. How do you know theres a fault in this rock? Try to line up the same type of rock on either side of the lines that cut across them. One side moved relative to the other side, so you know the lines are a fault. Slip is the distance rocks move along a fault. Slip can be up or down the fault plane. Slip is relative, because there is usually no way to know whether both sides moved or only one. Faults lie at an angle to the horizontal surface of the Earth. That angle is called the faults dip. The dip defines which of two basic types a fault is. If the faults dip is inclined relative to the horizontal, the fault is a dip-slip fault (Figure 1.3). There are two types of dip-slip faults. In a normal fault, the hanging wall drops down relative to the footwall. In a reverse fault, the footwall drops down relative to the hanging wall. This diagram illustrates the two types of dip-slip faults: normal faults and reverse faults. Imagine miners extracting a re- source along a fault. The hanging wall is where miners would have hung their lanterns. The footwall is where they would have walked. A thrust fault is a type of reverse fault in which the fault plane angle is nearly horizontal. Rocks can slip many miles along thrust faults (Figure 1.4). At Chief Mountain in Montana, the upper rocks at the Lewis Overthrust are more than 1 billion years older than the lower rocks. How could this happen? Normal faults can be huge. They are responsible for uplifting mountain ranges in regions experiencing tensional stress. A strike-slip fault is a dip-slip fault in which the dip of the fault plane is vertical. Strike-slip faults result from shear stresses. Imagine placing one foot on either side of a strike-slip fault. One block moves toward you. If that block moves toward your right foot, the fault is a right-lateral strike-slip fault; if that block moves toward your left foot, the fault is a left-lateral strike-slip fault (Figure 1.5). Californias San Andreas Fault is the worlds most famous strike-slip fault. It is a right-lateral strike slip fault (See opening image). People sometimes say that California will fall into the ocean someday, which is not true. Strike-slip faults. Click image to the left or use the URL below. URL:", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}371{"query": "Guillaume Emmanuel Guignard, vicomte de Saint-Priest (4 March 1776 in Constantinople -- 29 March 1814) was a French emigre general who fought in the Russian army during the French Revolutionary Wars and the Napoleonic Wars.", "pos": "Samuel McClellan (4 January 1730 -- 17 October 1807) was a Brigadier General in the American Revolutionary War.", "neg": "Elie Lacoste (18 September 1745, Montignac - 26 November 1806, Montignac) was a French politician during the French Revolution.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}372{"query": "Empagliflozin is a selective sodium glucose cotransporter 2 (SGLT2) inhibitor that inhibits renal glucose reabsorption and is being investigated for the treatment of type 2 diabetes mellitus (T2DM). In this open-label study, the effect of renal impairment on the pharmacokinetics, pharmacodynamics and safety of a 50mg dose of empagliflozin was investigated in 40 subjects, grouped according to estimated glomerular filtration rate (eGFR). Maximum empagliflozin plasma concentrations were similar in subjects with normal renal function and renal impairment. Area under the empagliflozin concentration-time curve (AUC0 - ) values increased by approximately 18, 20, 66 and 48% in subjects with mild, moderate, severe renal impairment and renal failure/end stage renal disease (ESRD), respectively, in comparison to healthy subjects. This was attributed to decreased renal clearance (CLR ). Urinary glucose excretion (UGE) decreased with increasing renal impairment and correlated with decreased eGFR and CLR . Empagliflozin was well tolerated, with no increase in adverse events associated with renal impairment. Renal insufficiency resulted in decreased CLR of empagliflozin, moderately increased systemic exposure and decreased UGE. A single 50mg dose of empagliflozin was well tolerated in subjects with normal renal function and any degree of renal impairment. The pharmacokinetic results of this study indicate that no dose adjustment of empagliflozin is required in patients with renal impairment.", "pos": "To evaluate the effects of the sodium glucose cotransporter 2 (SGLT2) inhibitor empagliflozin added to metformin for 12weeks in patients with type 2 diabetes. This dose-ranging, double-blind, placebo-controlled trial randomized 495 participants with type 2 diabetes inadequately controlled on metformin [haemoglobin A1c (HbA1c) >7 to 10%] to receive 1, 5, 10, 25, or 50mg empagliflozin once daily (QD), or placebo, or open-label sitagliptin (100mg QD), added to metformin for 12weeks. The primary endpoint was change in HbA1c from baseline to week 12 (empagliflozin groups versus placebo). Reductions in HbA1c of -0.09 to -0.56% were observed with empagliflozin after 12weeks, versus an increase of 0.15% with placebo (baseline: 7.8-8.1%). Compared with placebo, empagliflozin doses from 5 to 50mg resulted in reductions in fasting plasma glucose (-2 to -28mg/dl vs. 5mg/dl with placebo; p<0.0001) and body weight (-2.3 to -2.9kg vs. -1.2kg; p<0.01). Frequency of adverse events was generally similar with empagliflozin (29.6-48.6%), placebo (36.6%) and sitagliptin (35.2%). Hypoglycaemia rates were very low and balanced among groups. Most frequent adverse events with empagliflozin were urinary tract infections (4.0% vs. 2.8% with placebo) and pollakiuria (2.5% vs. 1.4% with placebo). Genital infections were reported only with empagliflozin (4.0%). Once daily empagliflozin as add-on therapy to metformin was well tolerated except for increased genital infections and resulted in reductions in HbA1c, fasting plasma glucose and body weight in patients with type 2 diabetes inadequately controlled on metformin monotherapy.", "neg": "Ghrelin exhibits its biological effect through binding to the growth hormone secretagogue 1a receptor (GHS-R1a). Recently, it has been reported that ghrelin has an anti-apoptotic effect in several cell types. However, the molecule mechanisms underlying the anti-apoptotic effect of ghrelin remain poorly understood. In this study, we investigated the intracellular mechanisms responsible for anti-apoptotic effect of ghrelin on human umbilical vein endothelial cells (HUVEC). Treatment of HUVEC with ghrelin inhibited high glucose-induced cell apoptosis. Ghrelin stimulated the rapid phosphorylation of mammalian target of rapamycin (mTOR), P70S6K and S6. The GHS-R1a-specific antagonist [D-Lys3]-GHRP-6 abolished the anti-apoptotic effect and inhibited the activation of mTOR, P70S6K, S6 induced by ghrelin. Pretreatment of cells with specific inhibitor of mTOR blocked the anti-apoptotic effect of ghrelin. In addition, ghrelin protected HUVECs against high glucose induced apoptosis by increasing Bcl-2/Bax ratio. Taken together, our results demonstrate that ghrelin produces a protective effect on HUVECs through activating GHS-R1a and mTOR/P70S6K signaling pathway mediates the effect of ghrelin. These observations suggest that ghrelin may act as a survival factor in preventing HUVECs apoptosis caused by high glucose.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}373{"query": "Arnus Vallis is an ancient river valley in the Syrtis Major quadrangle of Mars, located at 14.1 north latitude and 289.5 west longitude.", "pos": "Bahram Vallis is an ancient river valley in the Lunae Palus quadrangle of Mars at 20.7 north latitude and 57.5 west longitude.", "neg": "1303 Luthera (1928 FP) is an outer main-belt asteroid discovered on March 16, 1928, by Friedrich Karl Arnold Schwassmann at Hamburg-Bergedorf Observatory.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}374{"query": "Streams are bodies of water that have a current; they are in constant motion. Geologists recognize many categories of streams depending on their size, depth, speed, and location. Creeks, brooks, tributaries, bayous, and rivers are all streams. In streams, water always flows downhill, but the form that downhill movement takes varies with rock type, topography, and many other factors. Stream erosion and deposition are extremely important creators and destroyers of landforms. Rivers are the largest streams. People have used rivers since the beginning of civilization as a source of water, food, transportation, defense, power, recreation, and waste disposal. With its high mountains, valleys and Pacific coastline, the western United States exhibits nearly all of the features common to rivers and streams. The photos below are from the western states of Montana, California and Colorado. A stream originates at its source. A source is likely to be in the high mountains where snows collect in winter and melt in summer, or a source might be a spring. A stream may have more than one source. Two streams come together at a confluence. The smaller of the two streams is a tributary of the larger stream (Figure 1.1). The confluence between the Yellowstone River and one of its tributaries, the Gar- diner River, in Montana. The point at which a stream comes into a large body of water, like an ocean or a lake, is called the mouth. Where the stream meets the ocean or lake is an estuary (Figure 1.2). The mouth of the Klamath River creates an estuary where it flows into the Pacific Ocean in California. The mix of fresh and salt water where a river runs into the ocean creates a diversity of environments where many different types of organisms create unique ecosystems. As a stream flows from higher elevations, like in the mountains, towards lower elevations, like the ocean, the work of the stream changes. At a streams headwaters, often high in the mountains, gradients are steep (Figure 1.3). The stream moves fast and does lots of work eroding the stream bed. Headwaters of the Roaring Fork River in Colorado. As a stream moves into lower areas, the gradient is not as steep. Now the stream does more work eroding the edges of its banks. Many streams develop curves in their channels called meanders (Figure 1.4). As the river moves onto flatter ground, the stream erodes the outer edges of its banks to carve a floodplain, which is a flat, level area surrounding the stream channel (Figure 1.5). Base level is where a stream meets a large body of standing water, usually the ocean, but sometimes a lake or pond. Streams work to down cut in their stream beds until they reach base level. The higher the elevation, the farther the stream is from where it will reach base level and the more cutting it has to do. The ultimate base level is sea level. A divide is a topographically high area that separates a landscape into different water basins (Figure 1.6). Rain that falls on the north side of a ridge flows into the northern drainage basin and rain that falls on the south side flows into the southern drainage basin. On a much grander scale, entire continents have divides, known as continental divides. A green floodplain surrounds the Red Rock River as it flows through Montana. (a) The divides of North America. In the Rocky Mountains in Colorado, where does a raindrop falling on the western slope end up? How about on the eastern slope? (b) At Triple Divide Peak in Montana water may flow to the Pacific, the Atlantic, or Hudson Bay depending on where it falls. Can you locate where in the map of North America this peak sits?", "pos": "To be a good aquifer, the rock in the aquifer must have good: porosity: small spaces between grains permeability: connections between pores To reach an aquifer, surface water infiltrates downward into the ground through tiny spaces or pores in the rock. The water travels down through the permeable rock until it reaches a layer that does not have pores; this rock is impermeable (Figure 1.1). This impermeable rock layer forms the base of the aquifer. The upper surface where the groundwater reaches is the water table. Groundwater is found beneath the solid surface. Notice that the water table roughly mirrors the slope of the lands surface. A well penetrates the water table. For a groundwater aquifer to contain the same amount of water, the amount of recharge must equal the amount of discharge. What are the likely sources of recharge? What are the likely sources of discharge? What happens to the water table when there is a lot of rainfall? What happens when there is a drought? Although groundwater levels do not rise and fall as rapidly as at the surface, over time the water table will rise during wet periods and fall during droughts. In wet regions, streams are fed by groundwater; the surface of the stream is the top of the water table (Figure 1.2). In dry regions, water seeps down from the stream into the aquifer. These streams are often dry much of the year. Water leaves a groundwater reservoir in streams or springs. People take water from aquifers, too. Groundwater meets the surface in a stream (Figure 1.2) or a spring (Figure 1.3). A spring may be constant, or may only flow at certain times of year. Towns in many locations depend on water from springs. Springs can be an extremely important source of water in locations where surface water is scarce. A well is created by digging or drilling to reach groundwater. It is important for anyone who intends to dig a well to know how deep beneath the surface the water table is. When the water table is close to the surface, wells are a convenient method for extracting water. When the water table is far below the surface, specialized equipment must The top of the stream is the top of the water table. The stream feeds the aquifer. A spring in Croatia bubbles to the surface and feeds the river Cetina. be used to dig a well. Most wells use motorized pumps to bring water to the surface, but some still require people to use a bucket to draw water up (Figure 1.4). An old-fashioned well that uses a bucket drawn up by hand.", "neg": "Most sedimentary rocks form from sediments. Sediments are small pieces of other rocks, like pebbles, sand, silt, and clay. Sedimentary rocks may include fossils. Fossils are materials left behind by once-living organisms. Fossils can be pieces of the organism, like bones. They can also be traces of the organism, like footprints. Most often, sediments settle out of water (Figure 4.13). For example, rivers carry lots of sediment. Where the water slows, it dumps these sediments along its banks, into lakes and the ocean. When sediments settle out of water, they form horizontal layers. A layer of sediment is deposited. Then the next layer is deposited on top of that layer. So each layer in a sedimentary rock is younger than the layer under it. It is older than the layer over it. Sediments are deposited in many different types of environments. Beaches and deserts collect large deposits of sand. Sediments also continuously wind up at the bottom of the ocean and in lakes, ponds, rivers, marshes, and swamps. Avalanches produce large piles of sediment. The environment where the sediments are deposited determines the type of sedimentary rock that can form. Sedimentary rocks form in two ways. Particles may be cemented together. Chemicals may precipitate. Over time, deposited sediments may harden into rock. First, the sediments are compacted. That is, they are squeezed together by the weight of sediments on top of them. Next, the sediments are cemented together. Minerals fill in the spaces between the loose sediment particles. These cementing minerals come from the water that moves through the sediments. These types of sedimentary rocks are called clastic rocks. Clastic rocks are rock fragments that are compacted and cemented together. Clastic sedimentary rocks are grouped by the size of the sediment they contain. Conglomerate and breccia are made of individual stones that have been cemented together. In conglomerate, the stones are rounded. In breccia, the stones are angular. Sandstone is made of sand-sized particles. Siltstone is made of smaller particles. Silt is smaller than sand but larger than clay. Shale has the smallest grain size. Shale is made mostly of clay-sized particles and hardened mud. Chemical sedimentary rocks form when crystals precipitate out from a liquid. The mineral halite, also called rock salt, forms this way. You can make halite! Leave a shallow dish of salt water out in the Sun. As the water evaporates, salt crystals form in the dish. There are other chemical sedimentary rocks, like gypsum. Table 4.1 shows some common types of sedimentary rocks and the types of sediments that make them up. Picture Rock Name Conglomerate Type of Sedimentary Rock Clastic Breccia Clastic Sandstone Clastic Siltstone Clastic Limestone Bioclastic Coal Organic Picture Rock Name Rock Salt Type of Sedimentary Rock Chemical precipitate", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}375{"query": "Christian Chalmin, publisher, born in 1947 at Autry-Issards and Mayor of the commune from 1989 to 1995.", "pos": "The current Mayor of Brescia is Emilio Del Bono (PD), elected on June 10, 2013.", "neg": "Claire Ridgway (born 1971) is a British writer of history books about the Tudor dynasty, with a particular focus on the life of the Boleyn family.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}376{"query": "Increased nerve growth factor levels are associated with chronic pain conditions, including chronic low back pain (LBP). This study examined safety and analgesic efficacy of tanezumab, a humanized anti-nerve growth factor antibody, in adults with chronic LBP. Patients received intravenous tanezumab 200 g/kg plus oral placebo (n=88), intravenous placebo plus oral naproxen 500 mg twice a day (n=88), or intravenous placebo plus oral placebo (n=41). Primary outcome was average LBP intensity (aLBPI) at Week 6. Secondary outcomes were proportion of patients with 30% or 50% reduction in aLBPI, Roland-Morris Disability Questionnaire and Brief Pain Inventory-short form scores, Patients' Global Assessment of LBP, Patients' Global Evaluation of study medication, and rescue medication use. Mean aLBPI change from baseline to Week 6 was greater with tanezumab vs naproxen (P=0.004) and placebo (P<0.001). Greater proportions of patients reported 30% and 50% reduction in aLBPI with tanezumab vs naproxen (P0.013) and placebo (P<0.001), and greater improvements in Roland-Morris Disability Questionnaire (P<0.001) and other secondary outcomes except rescue medication use. Tanezumab was associated with adverse events (AEs) of abnormal peripheral sensation that were generally mild and resolved before study completion; however, there were no serious AEs. Nine patients (4 of whom were tanezumab-treated) discontinued due to AEs. In conclusion, tanezumab resulted in analgesic efficacy that was clinically and statistically superior to placebo and naproxen in patients with chronic LBP. Tanezumab clinical development is on regulatory hold due to AEs in osteoarthritis patients.", "pos": "Tanezumab is a humanized monoclonal antibody that specifically inhibits nerve growth factor as a treatment for chronic pain. This phase IIB study investigated the efficacy and safety of tanezumab for chronic low back pain vs placebo and naproxen. Patients (N=1347) received intravenous tanezumab (5, 10, or 20mg every 8weeks), naproxen (500mg twice daily), or placebo. The primary efficacy end point was mean change in daily average low back pain intensity (LBPI) from baseline to week 16. Secondary end points included mean change from baseline to week 16 in the Roland Morris Disability Questionnaire and Patient's Global Assessment (PGA) of low back pain. Tanezumab 10 and 20mg had similar efficacy profiles and significantly improved LBPI, Roland Morris Disability Questionnaire, and PGA scores vs both placebo and naproxen (P.05). Tanezumab 5mg provided improvement of PGA scores vs placebo (P.05), and naproxen resulted in significant improvement of LBPI vs placebo (P.05). Adverse event incidence was comparable across tanezumab doses but higher than with placebo or naproxen. Arthralgia, pain in extremity, headache, and paresthesia were the most commonly reported adverse events by tanezumab-treated patients. The most frequently reported adverse events resulting in discontinuation of tanezumab treatment were arthralgia and paresthesia; the highest frequency was observed with tanezumab 20mg (both 1.4%). Serious adverse event incidence was similar across treatments. In conclusion, tanezumab provided significantly greater improvement in pain, function, and global scores vs placebo and naproxen in patients with chronic low back pain.", "neg": "The SP790 study (ClinicalTrials.gov, NCT00136045) showed benefits of rotigotine over placebo in improving symptom severity of restless legs syndrome (RLS), also known as Willis-Ekbom disease, on the International Restless Legs Syndrome Study Group rating scale (IRLS), Clinical Global Impression item 1 (CGI-1), RLS 6-item questionnaire (RLS-6), and the RLS-quality of life questionnaire (RLS-QoL) in patients with moderate to severe idiopathic RLS. To provide clinical context for the IRLS and to guide the choice of assessment scales for RLS studies, our post hoc analysis of SP790 data evaluated associations between the IRLS and the CGI-1, IRLS and RLS-6, and the IRLS and RLS-QoL. Scale associations were analyzed at baseline and at the end of maintenance (EoM) using data from the safety set (rotigotine and placebo groups combined [n=458]). Changes from baseline to EoM in IRLS score vs comparator scale scores also were analyzed. There was a trend towards increasing IRLS severity category with increasing CGI-1, RLS-6, and RLS-QoL score. Pearson product moment correlation coefficients showed correlations between IRLS and comparator scale scores at baseline and EoM as well as correlations for change from baseline to EoM. Correlations between the IRLS and comparator scales were substantial. These data indicate that the IRLS is clinically meaningful. The IRLS and CGI-1 are generally sufficient to evaluate the overall severity and impact of RLS symptoms in clinical trials.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}377{"query": "Extrapolating the figures from a previous study on FSHD in a province of The Netherlands to the entire Dutch population suggests that at present a nearly complete overview is obtained of all symptomatic kindred. In 139 families, dominant inheritance was observed in 97, a pattern compatible with germline mosaicism in 6, while sporadic cases were found in 36 families. A mutation frequency of 9.6% was calculated. Mental retardation and severe retinal vasculopathy were reported in low frequencies (1%). Early onset was seen more frequently in sporadic cases. Chromosome 4 linkage appeared excluded in 3 of 22 autosomal-dominant families. The clinical pictures in the linked and nonlinked families were identical.", "pos": "Facioscapulohumeral muscular dystrophy (FSHD) is a primary muscle disorder with autosomal dominant inheritance. FSHD was mapped to chromosome 4 locus q35, but the gene is not yet known. It is characterised by progressive, often asymmetric, selective muscular weakness and great clinical variability. The aim of the study was to analyze 62 FSHD cases from 44 Polish families in which the diagnosis was confirmed by DNA analyses. FSHD diagnosis was based on the clinical findings and standardized investigations confirming primary muscular involvement (EMG, muscle biopsy). DNA analysis was based on EcoRI/BlnI restriction enzyme digestion followed by hybridization with P13E-11 molecular probe. In our material, we have found a relatively large percentage (41%) of big deletions (EcoRI/BlnI fragment of 10-15 kb [kilo bases]), which in the majority of cases (67%) was present in isolated cases. In 10 families (23%) the phenotype was assessed as severe. These are cases with the onset before the age of 10 and fast progression. \"Middle sized\" deletions (EcoRI/BlnI fragment of 16-29 kb) were prevalent in familial cases and present in 57% of families. \"Small\" deletion was found in one family (EcoRI/BlnI fragment of 30 kb). Somatic mosaicism was confirmed in one case. De novo mutations were shown in 11% of the examined families. The results of this study indicate that the bigger the deletion, the more severe the FSHD course, however there are some exceptions. A similar relationship has been shown by previous research. Molecular analyses are particularly important in atypical and sporadic cases. It is the first genetic presentation of a group of patients' with this kind of dystrophy in the Polish population.", "neg": "Although peak finding in next-generation sequencing (NGS) datasets has been addressed extensively, there is no consensus on how to analyze and process biological replicates. Furthermore, most peak finders do not focus on accurate determination of enrichment site widths and are not widely applicable to different types of datasets. We developed JAMM (Joint Analysis of NGS replicates via Mixture Model clustering): a peak finder that can integrate information from biological replicates, determine enrichment site widths accurately and resolve neighboring narrow peaks. JAMM is a universal peak finder that is applicable to different types of datasets. We show that JAMM is among the best performing peak finders in terms of site detection accuracy and in terms of accurate determination of enrichment sites widths. In addition, JAMM's replicate integration improves peak spatial resolution, sorting and peak finding accuracy. JAMM is available for free and can run on Linux machines through the command line: [Link]", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}378{"query": "Coming off their divisional road win over the Rams, the Cardinals went home for a Week 10 NFC West rematch with the San Francisco 49ers on Monday Night Football. In the first quarter, Arizona trailed early as 49ers CB Allen Rossum returned the game's opening kickoff 104 yards for a touchdown. The Cardinals would respond as kicker Neil Rackers got a 28-yard field goal. In the second quarter, San Francisco added onto their lead as QB Shaun Hill completed a 31-yard TD pass to WR Josh Morgan. The Cardinals would answer with QB Kurt Warner completing a 13-yard TD pass to WR Anquan Boldin, along with Rackers getting a 33-yard field goal. The 49ers would close out the half with Hill completing an 18-yard TD pass to TE Vernon Davis. In the third quarter, Arizona crept closer again as Warner completed a five-yard TD pass to WR Larry Fitzgerald, yet San Francisco replied with kicker Joe Nedney getting a 41-yard field goal. In the fourth quarter, the Cardinals took the lead as Rackers nailed a 23-yard field goal, along with Warner hooking up with Boldin again on a five-yard TD pass (with a failed two-point conversion.) The 49ers would mount a late comeback drive, but Arizona made a successful goal-line stand as time ran out.", "pos": "Coming off their win over the Browns, the Bears stayed at home for a Week 9 duel with the Arizona Cardinals. Chicago would trail early in the first quarter as Cardinals quarterback Kurt Warner hooked up with wide receiver Larry Fitzgerald on an 11-yard touchdown pass. The Bears would answer as quarterback Jay Cutler competed a 33-yard touchdown pass to tight end Greg Olsen, but Arizona came right back as Warner hooked up with tight end Ben Patrick on a 6-yard touchdown pass. Chicago would find themselves in a huge deficit in the second quarter as Warner completed a 17-yard touchdown pass to Fitzpatrick and a 15-yard touchdown pass to tight end Anthony Becht, followed by kicker Neil Rackers nailing a 43-yard field goal. The Cardinals would add onto their lead as Rackers booted a 30-yard field goal in the third quarter. The Bears tried to rally in the fourth quarter as Cutler connected with Olsen on a 3-yard and a 20-yard touchdown pass, but Arizona pulled away with Warner completing a 4-yard touchdown pass to wide receiver Steve Breaston.", "neg": "This game is well known for an infamous penalty that occurred during the overtime period. The Jets were lining up for a game winning 56-yard field goal in overtime to try and give them the win. Nick folk kicked the ball, but the kick went wide right and the Patriots appeared to be taking over with a chance to win. However, Chris Jones of New England was called for a controversial unsportsmanlike conduct penalty after pushing his teammate into the offensive line. This penalty would later be named \"leaping\". The penalty gave the Jets another chance and made the field goal attempt a 51-yard attempt. This time, Folk drilled the kick, and the Jets would go on to stun the Patriots. With the win, the Jets improved to 4-3.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}379{"query": "Cynthia Nelson (Mariette Hartley), a teacher at the local orphanage, talks with a pastor while watching the sun set before getting ready for a fundraising costume party. Cynthia mentions the \"Santa Ana winds\" which the pastor states are an evil omen. One the orphans, Tommy, wanders into the nearby cemetery where he faintly hears a voice ordering \"To rise; it is time.\" Vampire women rise from their graves and chase Tommy into the clutches of Count Yorga, who was waiting for them. Yorga, having been in the area while creating his undead harem and hiding them in the cemetery, has purchased a manor next to the orphanage. His intent is to prey on the children and staff there to satisfy his and his vampire-brides' thirst for blood and presumably create an undead-army from the community's women. In his human guise, he goes to the orphanage during their costume party and fund raiser, biting on of the guests, Mitzi, outside the event room before introducing himself to those present to which he meets and becomes smitten with Cynthia. Upon returning to his manor and a throne room of sorts where he's greeted by his Brudah and his female vampire servants, sends his undead brides to her house, using mind-control to get Cynthia's family into one room before having the brides break in and attack them. Cynthia's father and mother are killed after being drained of their blood, while Cynthia's sister, Ellen, is fed upon and transformed into a new vampire bride to serve Yorga. Tommy, who was sleeping over, is untouched having fallen under Yorga's power, and blankly looks on as the carnage unfolds. Cynthia is subdued (though not bitten) and carried by the brides to Yorga's residence where she awakens with no memory of the attack. Yorga tells Cynthia that her family were in a car accident and she was left in his care during their recovery. Yorga tries to charm the young woman into willingly becoming his bride though he is warned by his live-in witch that Cynthia will bring his end if he doesn't kill her or turn her into a vampire soon. The next morning, Jennifer, the Nelsons' mute maid, finds the massacre scene and calls the police. By the time the police arrive though, all of the evidence has been mysteriously cleared away, and Tommy claims that nothing has happened. Later that same morning, Bruddah, Yorga's hulking, facially disfigured servant (like Yorga, also returning from an on-screen death in the first film) drags the corpses of Cynthia's mother and father to a quicksand pit on Yorga's property, disposing of the physical evidence while likewise bring Ellen's body to Yorga to complete her transformation. Despite the confusion, David Baldwin, Cynthia's fiance, is suspicious about the Nelsons' disappearance. Meanwhile, memories of the attack on her family slowly start to resurface in Cynthia's mind as she stays within Yorga's manor. Jennifer, suspicious about Tommy's involvement with the Nelson's disappearance and his visits to Yorga's mansion, loses her patience and slaps Tommy who stares at her in a vengeful manner. Meanwhile, Yorga goes to claim Mitzi, killing her boyfriend near their boat house then biting her, draining her blood and making her a new bride. Hours later, Ellen's fiance Jason is lured to Yorga's mansion by Tommy, on the promise that he would find Ellen. Once at the mansion, Tommy disappears, while Jason is reunited with Ellen. However, in her vampirized state, she is now evil and laughs at him for \"not loving her anymore\", distracting him before her fellow brides attack him from behind. Jason breaks free, only to run into Count Yorga, who chases Jason down a hall and strangles him. Bruddah tosses Jason's body into the throne/coffin room for the brides, including Ellen and newly vampiric Mitzi, to feed upon. That evening, Reverend Thomas phones Jennifer, but it is revealed she lay dead on her bed with a large knife sticking out of her chest. From her window, Tommy can be seen walking", "pos": "Its been over a year since the Alaskan town of Barrow's population was decimated by a gang of vampires during its annual month long sunset. Riddled with grief over the death of her husband, bound by nightmares and void of all emotions beyond hate and sorrow, Stella (Kiele Sanchez) has spent the past months traveling the world, trying to convince others that vampires exist in this world.Constantly feeling as though she is being hunted, Stella is well aware the impending threat on her life, the death of her husband Eben having taken from her her ability to feel emotions, leaving her feeling cold and empty inside. Following instructions from a mysterious man named Dane, she eventually ends up in Los Angeles.One night, while giving a lecture to an audience of people with whom she hopes to convince that vampires exist and aware that they attend when she speaks, she activates overhead ultraviolet lamps that incinerate several of the vampires in the audience before the humans. She is quickly arrested and harassed by a man named FBI Agent Norris whom she quickly learns that he is a 'familiar' (bug-eater) one of the many thousands of human followers of the vampires all over the world, placed to keep their activities covered up. After they release her from custody with a warning to keep quiet about the existence of vampires, she returns to her hotel room to find three people waiting for her; Paul (Rhys Coiro), Amber (Diora Baird) and Todd (Harold Perrineau) who had been sent by Dane to collect her in order to hunt down the vampire queen Lilith, whom they are convinced once out of the way, the vampires will fall into more-or-less form of dormancy as she is responsible for their every move and for keeping them hidden, when Stella asks if she is responsible for the incident at Barrow and is notified that she was. She is taken to meet Dane (Ben Cotton) and is shocked to discover that he too is a vampire, though due to a superficially inflicted wound he has maintained a grasp of humanity, only drinking blood from packaged hospital stocks he keeps.At first hesitant to join in on a plan to attack a vampire nest, Paul eventually convinces Stella to join them, telling her of his daughter being killed by one and his accusations of a vampire killing her resulting in a divorce with his wife.The following day, the four of them find their way to a vampire's nest and they are ambushed by a group of them. In the attempt to flee, Todd is bitten and turns after they lock themselves in a cellar room. When Paul hesitates, Stella manages to kill him by smashing in his head with a cinder block. They decide to wait for night when the vampires go out to feed in order to make their escape.After night falls, Dane comes and frees them, on their way out they capture a vampire. Taking him back to their base of operations, Dane interrogates the non-English speaking animalistic vamp with ultraviolet lamps, eventually following him back to another nest. They invade the nest and rescue a human they were using as a feeding station and with her memories of Lilith's lair aboard one of the ships on the bay they are able to plan an attack on her directly.At Dane's place, Stella and Paul get intimate and have sex. Meanwhile, Lilith (Mia Kirshner) decides that Agent Norris should prove his worth to become a vampire (in order to cure throat or lung cancer he has been suffering from) and he bites the neck of a captive girl, named Stacey (Katharine Isabelle), drinking her blood until dead. Afterward she turns him to hunt Stella and the others.Dane is killed when Norris arrives, and the others flee with the survivor from the nest, they travel to a boat yard and Jennifer points out the boat that they are set to sail to Alaska in for another 30 day feeding period. They tell Jennifer to leave and the three of them stowaway on the ship and discover that vampires can be resurrected after death if their corpses are fed human blood. They eventually confront the human captain who says", "neg": "The movie begins in the year 1967 with a pregnant woman being admitted to a hospital, bleeding from the neck. Paramedics think she was attacked by some type of animal. Doctors perform an emergency C-Section, and her baby (a boy) is born alive just as she dies.Thirty years later a young man named Dennis (Kenny Johnson) is riding in a car with an attractive redhead named Racquel (Traci Lords) heading to an underground nightclub (located, oddly, in a slaughterhouse) somewhere in Los Angeles. After addressing the doorman in Russian, Racquel brings the young man into the club. The man is confused and trying to understand the rules of the club. Some of the regulars indifferently push him aside. Saying he needs a drink, the sprinkler suddenly system activates, raining blood down on everyone inside. It is then that he (and the audience) realizes that everyone in the club is a vampire.Dennis desperately tries to get away and winds up at the feet of a menacing figure in a black-leather trenchcoat. The vampires look on this figure with awe, mumbling the words: \"it's the Daywalker!\" This is our first look at Blade (Wesley Snipes), the vampire killer.Blade pulls out a shotgun and opens fire on the vampires, who instantly burn to ashes when killed. When the gun is knocked out of his hands by Racquel, Blade uses a set of silver stakes to kill Racquel and more vampires, including the disk jockey. Soon all the vamps are either dead or have fled except for one; a heavyset vamp named Quinn (Donal Logue), whom Blade has apparently run into before. Blade pins Quinn to the wall, and then sets him on fire before confronting the last member in the club (the human man from the beginning). Finding no vampire bite marks on Dennis, Blade lets him live and makes his escape as the police arrive.Quinn is extinguished and taken to the local hospital. A morgue technician examines his blood and shows the results to Dr. Karen Jenson (N'Bushe Wright), who finds a number of irregularities, including abnormally developed jaw muscles. As they are discussing the test results, Quinn springs back to life and bites both doctors. Before he can finish Dr. Jenson, Blade shows up and saves her, cutting off one of Quinn's arms.Blade brings Karen to his hideout and asks for help from his mentor, an elderly man named named Whistler (Kris Kristofferson). Whistler injects Dr. Jenson with a solution of garlic essence and silver nitrate and remarks that she has a 50/50 chance of recovering.Meanwhile, a group of vampires are discussing Blade's latest attack on their members. Apparently this club (and to an extent, Quinn) is the property of a vampire named Deacon Frost (Stephen Dorff). Frost wants the vampires to outright rule the humans and use them as a food source while the others (particularly an older vampire named Dragonetti) prefer to maintain a peaceful co-existance. Dragonetti (Udo Kier) in particular does not like Frost because Frost is not a \"pure-blood\" (ie: was not born a vampire, merely became one through the bite of another). Frost is also arrogant and his & the actions of his followers draw unnecessary attention to the vampire underworld.The next morning, Jenson awakens and sees Whistler injecting Blade with some type of serum. She tries to run away but Whistler confronts her and tells her that he and Blade are hunting vampires. Karen of course is skeptical, but Whistler goes on to talk about what they use to hunt- explaining that vampires are severely allergic to silver & garlic while also being vulnerable to sunlight (ultraviolet rays in particular). Whistler fuels up Blade's car and gives him a new UV flashlight to use when hunting that night. Whistler also gives Karen a type of \"vampire mace\" (garlic & silver nitrate in a liquid form).Blade drops Karen off at her apartment and she tries to pack up and get out of town. A police officer, identifying himself as Officer Krieger (Kevin Patrick Walls), arrives and questions her about the events", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}380{"query": "The effects of 2-[4-[(2,5-difluorophenyl) methoxy]phenoxy]-5-ethoxyaniline (SEA0400), a newly synthesized Na(+)-Ca(2+) exchanger (NCX) inhibitor, on the NCX current and other membrane currents were examined in isolated guinea-pig ventricular myocytes and compared with those of 2-[2-[4-(4-nitrobenzyloxy) phenyl]ethyl]isothiourea (KB-R7943). SEA0400 concentration-dependently inhibited the NCX current with a 10 fold higher potency than that of KB-R7943; 1 microM SEA0400 and 10 microM KB-R7943 inhibited the NCX current by more than 80%. KB-R7943, at 10 microM, inhibited the sodium current, L-type calcium current, delayed rectifier potassium current and inwardly rectifying potassium current by more than 50%, but SEA0400 (1 microM) had no significant effect on these currents. These results indicate that SEA0400 is a potent and highly selective inhibitor of NCX, and would be a powerful tool for further studies on the role of NCX in the heart and the therapeutic potential of its inhibition.", "pos": "Given the potential clinical benefit of inhibiting Na+/Ca2+ exchanger (NCX) activity during myocardial ischemia reperfusion (I/R), pharmacological approaches have been pursued to both inhibit and clarify the importance of this exchanger. SEA0400 was reported to have a potent NCX selectivity. Thus, we examined the effect of SEA0400 on NCX currents and I/R induced intracellular Ca2+ overload in mouse ventricular myocytes using patch clamp techniques and fluorescence measurements. Ischemia significantly inhibited inward and outward NCX current (from -0.04+/-0.01 nA to 0 nA at -100 mV; from 0.23+/-0.08 nA to 0.11+/-0.03 nA at +50 mV, n=7), Subsequent reperfusion not only restored the current rapidly but enhanced the current amplitude obviously, especially the outward currents (from 0.23+/-0.08 nA to 0.49+/-0.12 nA at +50 mV, n=7). [Ca2+]i, expressed as the ratio of Fura-2 fluorescence intensity, increased to 138+/-7% (P<0.01) during ischemia and to 210+/-11% (P<0.01) after reperfusion. The change of NCX current and the increase of [Ca2+]i during I/R can be blocked by SEA0400 in a dose-dependent manner with an EC50 value of 31 nM and 28 nM for the inward and outward NCX current, respectively. The results suggested that SEA0400 is a potent NCX inhibitor, which can protect mouse cardiac myocytes from Ca2+ overload during I/R injuries.", "neg": "A cell is the smallest structural and functional unit of an organism. Some organisms, like bacteria, consist of only one cell. Big organisms, like humans, consist of trillions of cells. Compare a human to a banana. On the outside, they look very different, but if you look close enough youll see that their cells are actually very similar. Most cells are so small that you cannot see them without the help of a microscope. It was not until 1665 that English scientist Robert Hooke invented a basic light microscope and observed cells for the first time, by looking at a piece of cork. You may use light microscopes in the classroom. You can use a light microscope to see cells ( Figure 1.1). But many structures in the cell are too small to see with a light microscope. So, what do you do if you want to see the tiny structures inside of cells? In the 1950s, scientists developed more powerful microscopes. A light microscope sends a beam of light through a specimen, or the object you are studying. A more powerful microscope, called an electron microscope, passes a beam of electrons through the specimen. Sending electrons through a cell allows us to see its smallest parts, even the parts inside the cell ( Figure 1.2). Without electron microscopes, we would not know what the inside of a cell looked like. The outline of onion cells are visible under a light microscope. In 1858, after using microscopes much better than Hookes first microscope, Rudolf Virchow developed the hypoth- esis that cells only come from other cells. For example, bacteria, which are single-celled organisms, divide in half (after they grow some) to make new bacteria. In the same way, your body makes new cells by dividing the cells you already have. In all cases, cells only come from cells that have existed before. This idea led to the development of one of the most important theories in biology, the cell theory. Cell theory states that: 1. All organisms are composed of cells. 2. Cells are alive and the basic living units of organization in all organisms. 3. All cells come from other cells. As with other scientific theories, many hundreds, if not thousands, of experiments support the cell theory. Since Virchow created the theory, no evidence has ever been identified to contradict it. Although cells share many of the same features and structures, they also can be very different ( Figure 1.3). Each cell in your body is designed for a specific task. In other words, the cells function is partly based on the cells structure. For example: Red blood cells are shaped with a pocket that traps oxygen and brings it to other body cells. Nerve cells are long and stringy in order to form a line of communication with other nerve cells, like a wire. Because of this shape, they can quickly send signals, such as the feeling of touching a hot stove, to your brain. Skin cells are flat and fit tightly together to protect your body. As you can see, cells are shaped in ways that help them do their jobs. Multicellular (many-celled) organisms have many types of specialized cells in their bodies. Red blood cells (left) are specialized to carry oxygen in the blood. Neurons (cen- ter ) are shaped to conduct electrical im- pulses to many other nerve cells. These epidermal cells (right) make up the skin of plants. Note how the cells fit tightly together. While cells are the basic units of an organism, groups of cells can perform a job together. These cells are called specialized because they have a special job. Specialized cells can be organized into tissues. For example, your liver cells are organized into liver tissue. Your liver tissue is further organized into an organ, your liver. Organs are formed from two or more specialized tissues working together to perform a job. All organs, from your heart to your liver, are made up of an organized group of tissues. These organs are part of a larger system, the organ systems. For example, your brain works", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}381{"query": "Humans evolved during the later Cenozoic. New fossil discoveries alter the details of what we know about the evolution of modern humans, but the major evolutionary path is well understood. Humans evolved from primates, and apes and humans have a primate common ancestor. About 7 million years ago, chimpanzees (our closest living relatives) and humans shared their last common ancestor. Animals of the genus Ardipithecus, living roughly 4 to 6 million years ago, had brains roughly the size of a female chimp. Although they lived in trees, they were bipedal. Standing on two feet allows an organism to see and also to use its hands and arms for hunting. By the time of Australopithecus afarensis, between 3.9 and 2.9 million years ago, these human ancestors were completely bipedal and their brains were growing rapidly (Figure 1.1). Australopithecus afarensis is a human ancestor that lived about 3 million years ago. The genus Homo appeared about 2.5 million years ago. Humans developed the first stone tools. Homo erectus evolved in Africa about 1.8 million years ago. Fossils of these animals show a much more human-like body structure, which allowed them to travel long distances to hunt. Cultures begin and evolve. Homo sapiens, our species, originated about 200,000 years ago in Africa. Evidence of a spiritual life appears about 32,000 years ago with stone figurines that probably have religious significance (Figure 1.2). The ice ages allowed humans to migrate. During the ice ages, water was frozen in glaciers and so land bridges such as the Bering Strait allowed humans to walk from the old world to the new world. DNA evidence suggests that the humans who migrated out of Africa interbred with Neanderthal since these people contain some Neanderthal DNA. Click image to the left or use the URL below. URL: Stone figurines likely indicate a spiritual life.", "pos": "Fossils are the preserved remains of animals, plants, and other organisms from the distant past. Examples of fossils include bones, teeth, and impressions. By studying fossils, evidence for evolution is revealed. Paleontologists are scientists who study fossils to learn about life in the past. Fossils allow these scientists to determine the features of extinct species. Paleontologists compare the features of species from different periods in history. With this information, they try to understand how species have evolved over millions of years ( Figure below). Until recently, fossils were the main source of evidence for evolution ( Figure below). Through studying fossils, we now know that todays organisms look much different in many cases than those that were alive in the past. Scientists have also shown that organisms were spread out differently across the planet. Earthquakes, volcanoes, shifting seas, and other movements of the continents have all affected where organisms live and how they adapted to their changing environments. There are many layers of rock in the Earths surface. Newer layers form on top of the older layers; the deepest rock layers are the oldest. Therefore, you can tell how old a fossil is by observing in which layer of rock it was found. Evolution of the horse. Fossil evi- dence, depicted by the skeletal frag- ments, demonstrates evolutionary mile- stones in this process. Notice the 57 million year evolution of the horse leg bones and teeth. Especially obvious is the transformation of the leg bones from having four distinct digits to that of todays horse. The fossils and the order in which fossils appear is called the fossil record. The fossil record provides evidence for when organisms lived on Earth, how species evolved, and how some species have gone extinct. Geologists use a method called radiometric dating to determine the exact age of rocks and fossils in each layer of rock. This technique, which is possible because radioactive materials decay at a known rate, measures how much of the radioactive materials in each rock layer have broken down ( Figure 1.3). Radiometric dating has been used to determine that the oldest known rocks on Earth are between 4 and 5 billion years old. The oldest fossils are between 3 and 4 billion years old. Remember that during Darwins time, people believed the Earth was just about 6,000 years old. The fossil record proves that Earth is much older than people once thought.", "neg": "Can you name some fossils? How about dinosaur bones or dinosaur footprints? Animal skeletons, teeth, shells, coprolites (otherwise known as feces), or any other remains or traces from a living creature that becomes rock is a fossil. The same processes that formed these fossils also created some of our most important energy resources, fossil fuels. Coal, oil, and natural gas are fossil fuels. Fossil fuels come from living matter starting about 500 million years ago. Millions of years ago, plants used energy from the Sun to form sugars, carbohydrates, and other energy-rich carbon compounds. As plants and animals died, their remains settled on the ground on land and in swamps, lakes, and seas (Figure 1.1). Over time, layer upon layer of these remains accumulated. Eventually, the layers were buried so deeply that they were crushed by an enormous mass of earth. The weight of this earth pressing down on these plant and animal remains created intense heat and pressure. After millions of years of heat and pressure, the material in these layers turned into chemicals called hydrocarbons (Figure 1.2). Hydrocarbons are made of carbon and hydrogen atoms. This molecule with one carbon and four hydrogen atoms is methane. Hydrocarbons can be solid, liquid, or gaseous. The solid form is what we know as coal. The liquid form is petroleum, or crude oil. Natural gas is the gaseous form. The solar energy stored in fossil fuels is a rich source of energy. Although fossil fuels provide very high quality energy, they are non-renewable. Click image to the left or use the URL below. URL:", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}382{"query": "The Duke's Cut was completed by the Duke of Marlborough in 1789 to link the new canal with the River Thames; and, in 1796, the Oxford Canal company built its own link to the Thames, at Isis Lock.", "pos": "A new canal with a port in Furth, the Rhine-Main-Danube Canal, was completed in 1992, creating a navigable connection from the Rhine delta in Rotterdam to the Danube Delta on the Black Sea.", "neg": "The Broadgate Tower was designed by Skidmore, Owings & Merrill and developed by British Land.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}383{"query": "Hoping to rebound from their home loss to the Patriots, the Cowboys stayed at home for a Week 7 intraconference game against the Minnesota Vikings. In the first quarter, Dallas scored first as QB Tony Romo completed a 5-yard TD pass to WR Terrell Owens. The Vikings would respond with RB Adrian Peterson getting a 20-yard TD run. In the second quarter, Minnesota took the lead after a turnover. WR Patrick Crayton fumbled a pass, which was picked up LB Ben Leber, who later lateraled the ball to CB Cedric Griffin, who would eventually fumble and recover the ball at the Cowboys 28-yard line and run it into the end zone for a touchdown. In the third quarter, RB Marion Barber got a 1-yard TD run, while Safety Pat Watkins returned a blocked field goal by Chris Canty 68 yards for a touchdown. It would mark the first time that a Cowboy player returned a blocked field goal since Ed \"Too Tall\" Jones in 1983 against the New Orleans Saints on Sept. 25, 1983. In the fourth quarter, Dallas sealed the victory with rookie Nick Folk getting a 45-yard field goal. With the win, the Cowboys entered their bye week at 6-1.", "pos": "Hoping to rebound from a divisional home loss to the Eagles, the Cowboys flew to Bank of America Stadium for a Week 16 Saturday night duel with the Carolina Panthers. In the first quarter, Dallas shot first with QB Tony Romo completing a 10-yard TD pass to WR Terrell Owens for the only score of the period. In the second quarter, the 'Boys continued their assault as RB Marion Barber got a 5-yard TD run. The Panthers would get on the board with QB Matt Moore completing an 11-yard TD pass to WR Steve Smith. The Cowboys end the half with rookie kicker Nick Folk getting a 42-yard field goal. In the third quarter, Carolina started to try a comeback as kicker John Kasay getting a 37-yard field goal for the only score of the period. In the fourth quarter, Dallas would respond with Folk kicking a 23-yard field goal. The Panthers tried to rally as Kasay nailing a 25-yard field goal, yet the 'Boys were able to hold off every possible attempt. With the win, the Cowboys improved to 13-2 and clinched homefield through NFC Playoffs with Green Bay's loss to Chicago on Sunday. Terrell Owens (5 receptions for 48 yards and 1 touchdown) left the game in the second quarter with a high left ankle sprain.", "neg": "Coming off their road win over the Packers, the Falcons went home for a Week 6 duel with the Chicago Bears. In the first quarter, Atlanta took flight as kicker Jason Elam got a 29-yard and a 48-yard field goal. In the second quarter, the Falcons increased their lead as Elam kicked a 32-yard field goal. The Bears would respond with kicker Robbie Gould getting a 36-yard field goal.Entering Sunday game with the Bears, the Falcons led the NFL in first quarter scoring with 48 points. After posting two field goals for a 6-0 lead following the first 15 minutes of play against Chicago, Atlanta has now outscored its opponent in the first quarter by a 54-14 margin. A chance at a touchdown came with 9:16 remaining in the first half after a curious turn of events near the goal line. A third-down run by Jerious Norwood came up short and ended with a fumble. Bears defensive tackle Tommie Harris recovered but lost the ball before he was touched down. Jason Snelling recovered the ball for the Falcons, who got a fresh set of downs. Following the first half of play, the Falcons defense held the Bears to 20 first half rushing yards. The 20 yards are the fewest given up in the first half of a game by Atlanta's defense since October 1, 2006, against Arizona (two yards). In the third quarter, the Falcons continued to add onto their lead as Elam got a 41-yard field goal, yet Chicago answered with RB Matt Forte getting a 3-yard TD run. In the fourth quarter, Atlanta replied with rookie quarterback Matt Ryan completing a 3-yard TD pass to WR Roddy White. Defensive end Jamaal Anderson paced a defense that fed off the crowd's energy. He finished with four tackles (two for loss) and the first sack of his two-year career. Anderson also had two pass deflections on the Bears' first drive of the second quarter.The Falcons offense started the second half with a no-huddle offense and added another Elam field goal to take a 12-3 lead. Chicago stuck with the running game and added a touchdown from Forte with 2:24 remaining in the third quarter. Chicago drove within inches of the end zone, but Matt Forte was stuffed on fourth down as he attempted to leap across the line. Michael Boley came in low to trip up the runner, then Lawyer Milloy and Keith Brooking finished him off.The Bears took the lead with Gould getting a 32-yard field goal, along with quarterback Kyle Orton completing a 17-yard TD pass to WR Rashied Davis. Fortunately, the Falcons got the last laugh as Elam nailed the game-winning 48-yard field goal.The 16-year veteran's celebration was interrupted by a swarm of teammates near midfield. It was his fifth successful kick of the day but just moments before he missed a kick that could have iced the game. Chicago came off the miscue with a 77-yard touchdown drive to take a 20-19 lead with 11 seconds to play. But a 9-yard return off a short kickoff by Harry Douglas and a 26-yard strike from rookie quarterback Matt Ryan to Michael Jenkins set Elam up for the game-winner with 1 second left. \"I'm really happy that one went through\", Elam said. \"Our guys have been fighting so hard for so long. I hate to even mention what happened last year but to hear some of the stories I know the guys are really hungry to get some wins on the board and show our fans what we're all about.\" With time to throw Ryan thrived. The rookie found five different receivers and performed regular Houdini-like acts to find open players down the field for third-down conversions. Fellow rookie Douglas caught five passes for 96 yards including a 47-yard strike on third down that set up a 3-yard scoring toss to White with 13:25 remaining.Ryan opened the game 8-of-8 for 107 yards and captained nearly identical scoring drives in the first quarter, leading the team on 48- and 49-yard marches that ended with field goals.\"I think everybody is excited with the win\", Ryan said. \"I thought we played a very good Chicago Bears team today", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}384{"query": "Riceyman Steps is a novel by British novelist Arnold Bennett, first published in 1923 and winner of that year's James Tait Black Memorial Prize for fiction.", "pos": "Rovering to Success is a book written by Robert Baden-Powell in 1922.", "neg": "Formed on 24 February 1910, Malmo FF is affiliated with Skanes Fotbollforbund and the team play their home games at the Swedbank Stadion.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}385{"query": "Earthquake magnitude affects how much damage is done in an earthquake. A larger earthquake damages more buildings and kills more people than a smaller earthquake. But thats not the only factor that determines earthquake damage. The location of an earthquake relative to a large city is important. More damage is done if the ground shakes for a long time. The amount of damage also depends on the geology of the region. Strong, solid bedrock shakes less than soft or wet soils. Wet soils liquefy during an earthquake and become like quicksand. Soil on a hillside that is shaken loose can become a landslide. Hazard maps help city planners choose the best locations for buildings (Figure 7.38). For example, when faced with two possible locations for a new hospital, planners must build on bedrock rather than silt and clay. The 1985 Mexico City earthquake measured magnitude 8.1. The earthquake killed at least 9,000 people, injured 30,000 more, and left 100,000 people homeless. It destroyed 416 buildings, and seriously damaged 3,000 other buildings. The intense destruction was due to the soft ground the city is built on. Silt and clay fill a basin made of solid rock. In an earthquake, seismic waves bounce back-and-forth off the sides and bottom of the rock basin. This amplifies the shaking. The wet clay converts to quicksand (Figure 7.39). Many buildings were not anchored to bedrock. They settled into the muck. This caused enormous damage. Water, sewer, and electrical systems were destroyed, resulting in fires. Acapulco was much closer to the epicenter, but since the city is built on bedrock it suffered little damage. The amount of damage depends on the amount of development in the region. The 1964 Great Alaska Earthquake, near Anchorage, was the largest earthquake ever recorded in North America. The gigantic quake had a magnitude of 9.2. The earthquake lasted for several minutes and the ground slipped up to 11.5 meters (38 feet). An area of 100,000 square miles (250,000 square km) was affected. The ground liquefied, causing landslides (Figure 7.40). The earthquake occurred at a subduction zone, and large tsunami up to 70 meters (20 feet) high were created. Despite the intensity of the earthquake, only 131 people died. Most deaths were due to the tsunami. Property damage was just over $300 million ($1.8 billion in 2007 U.S. dollars). The reason there was such a small amount of damage is that very few people lived in the area (Alaska had only been a state for five years!). A similar earthquake today would affect many more people. Buildings must be specially built to withstand earthquakes. Skyscrapers and other large structures built on soft ground must be anchored to bedrock. Sometimes that bedrock is hundreds of meters below the ground surface! Building materials need to be both strong and flexible. Small structures, like houses, should bend and sway. Wood and steel bend. Brick, stone, and adobe are brittle and will break. Larger buildings must sway, but not so much that they touch nearby buildings. Counterweights and diagonal steel beams can hold down sway. Buildings need strong, flexible connections where the walls meet the foundation. Earthquake-safe buildings are well connected (Figure Steel or wood can be added to older buildings to reinforce a buildings structure and its connections (Figure 7.42). Elevated freeways and bridges can also be reinforced so that they do not collapse. Important structures must be designed to survive intact. One of the biggest problems caused by earthquakes is fire. Fires start because earthquakes rupture gas and electrical lines. Water mains may break. This makes it difficult to fight the fires. The shapes of pipes can make a big difference. Straight pipes will break in a quake. Zigzag pipes bend and flex when the ground shakes. In San Francisco, water and gas pipelines are separated by valves. Areas can be isolated if one segment breaks. Strong, sturdy structures are expensive to build. Communities must decide how safe to make their buildings. They must weigh how great the hazard is, what different building strategies will cost, and how much risk they are", "pos": "Almost all earthquakes occur at plate boundaries. All types of plate boundaries have earthquakes. Convection within the Earth causes the plates to move. As the plates move, stresses build. When the stresses build too much, the rocks break. The break releases the energy that was stored in the rocks. The sudden release of energy creates an earthquake. During an earthquake the rocks usually move several centimeters or rarely as much as a few meters. Elastic rebound theory describes how earthquakes occur (Figure 7.21). Where an earthquake takes place is described by its focus and epicenter. The point where the rock ruptures is the earthquakes focus. The focus is below the Earths surface. A shallow earthquake has a focus less than 70 kilometers (45 miles). An intermediate-focus earthquake has a focus between 70 and 300 kilometers (45 to 200 miles). A deep-focus earthquake is greater than 300 kilometers (200 miles). About 75% of earthquakes have a focus in the top 10 to 15 kilometers (6 to 9 miles) of the crust. Shallow earthquakes cause the most damage. This is because the focus is near the Earths surface, where people live. The area just above the focus, on the land surface, is the earthquakes epicenter (Figure 7.22). The towns or cities near the epicenter will be strongly affected by the earthquake. Nearly 95% of all earthquakes take place along one of the three types of plate boundaries. As you learned in the Plate Tectonics chapter, scientists use the location of earthquakes to draw plate boundaries. The region around the Pacific Ocean is called the Pacific Ring of Fire. This is due to the volcanoes that line the region. The area also has the most earthquakes. About 80% of all earthquakes strike this area. The Pacific Ring of Fire is caused by the convergent and transform plate boundaries that line the Pacific Ocean basin. About 15% of all earthquakes take place in the Mediterranean-Asiatic belt. The convergent plate boundaries in the region are shrinking the Mediterranean Sea. The convergence is also causing the Himalayas to grow. The remaining 5% of earthquakes are scattered around the other plate boundaries. A few earthquakes take place in the middle of a plate, away from plate boundaries. Transform plate boundaries produce enormous and deadly earthquakes. These quakes at transform faults have shallow focus. This is because the plates slide past each other without moving up or down. The largest earthquake on the San Andreas Fault occurred in 1906 in San Francisco. Other significant earthquakes in California include the 1989 Loma Prieta earthquake near Santa Cruz (Figure 7.23) and the 1994 Northridge earthquake near Los Angeles. There are many other faults spreading off the San Andreas, which produce around 10,000 earthquakes a year (Figure Convergent plate boundaries also produce strong, deadly earthquakes. Earthquakes mark the motions of colliding plates and the locations where plates plunge into the mantle. These earthquakes can be shallow, intermediate or deep focus. The Philippine plate and the Pacific plate subduct beneath Japan, creating as many as 1,500 earthquakes every year. In March 2011, the 9.0 magnitude Tohoku earthquake struck off of northeastern Japan. Damage from the quake was severe. More severe was the damage from the tsunami generated by the quake (Figure 7.25). In all, 25,000 people were known dead or missing. The Cascades Volcanoes line the Pacific Northwest of the United States. Here, the Juan de Fuca plate subducts beneath the North American plate. The Cascades volcanoes are active and include Mount Saint Helens. Major earthquakes occur here approximately every 300 to 600 years. The last was in 1700. Its magnitude was between 8.7 and 9.2. It has now been more than 300 years since that earthquake. The next massive earthquake could strike the Pacific Northwest at any time. The collision of two continents also creates massive earthquakes. Many earthquakes happen in the region in and around the Himalayan Mountains. The 2001 Gujarat, India earthquake is responsible for about 20,000 deaths, with many more people injured or made homeless. Earthquakes also occur at divergent plate boundaries. At mid-ocean ridges, these earthquakes tend to be small and shallow focus because the", "neg": "A huge cloud of dust rose and an overpass disappeared. This was the scene in Zhuzhou,Hunan Province on May 17.Nine people were killed and 16 injured. Things were similar last year in the Sichuan earthquake. Thousands of people were buried in the ruins and lost their lives. What if we could have warned them? People are always _ to find a way of preventing buildings' collapse. Better materials and technology help,but they are not a solution. Just like humans,a building has its own life cycle from \"birth\" to \"death\".If we know when a building is going to collapse,we can repair it in advance or get out of it before it falls. Now,scientists at the University of Illinois have developed a material that turns red before it breaks. The invention could be used in things like climbing ropes or bridge supports. The research was led by Nancy Sottos,a professor at the university's Beckman Institute,and Douglas Davis,a graduate research assistant. The secret behind the colorchanging material is a type of molecule .A molecule is a group of atoms held together by chemical bonds. Imagine you and your friends standing in a circle,holding hands. Each person stands for one atom,your hands represent the bonds,and the entire circle represents a molecule. If one person lets go of his or her hands,the molecule changes color. The research team put the molecule into a soft material. When the researchers stretched the material,it turned bright red for a few seconds before it broke into two pieces. When they repeatedly stretched and relaxed the material,without breaking it,it only turned a little red. The major problem is that light can get rid of the red color. When the team shone bright light on the molecule,the broken bond was fixed,and the color disappeared. If the bright light keeps the red color from appearing,the material's warning system will be useless. Scientists still have a lot of work to do before the colorchanging molecules can be used outside the lab.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}386{"query": "Lewy bodies, neuropathological hallmarks of Parkinson's disease and dementia with Lewy bodies, comprise alpha-synuclein filaments and other less defined proteins. Characterization of Lewy body proteins that interact with alpha-synuclein may provide insight into the mechanism of Lewy body formation. Double immunofluorescence labeling and confocal microscopy revealed approximately 80% of cortical Lewy bodies contained microtubule-associated protein 1B (MAP-1B) that overlapped with alpha-synuclein. Lewy bodies were isolated using an immunomagnetic technique from brain tissue of patients dying with dementia with Lewy bodies. Lewy body proteins were resolved by polyacrylamide gel electrophoresis. Immunoblotting confirmed the presence of MAP-1B and alpha-synuclein in purified Lewy bodies. Direct binding studies revealed a high affinity interaction (IC(50) approximately 20 nm) between MAP-1B and alpha-synuclein. The MAP-1B-binding sites were mapped to the last 45 amino acids of the alpha-synuclein C terminus. MAP-1B also bound in vitro assembled alpha-synuclein fibrils. Thus, MAP-1B may be involved in the pathogenesis of Lewy bodies via its interaction with monomeric and fibrillar alpha-synuclein.", "pos": "The manifestation of Lewy bodies (LB) in the brain is a hallmark of Parkinson's disease. Here, we present a comprehensive analysis of protein elements in Lewy bodies by comparative mass spectrometry. Cortical LB inclusions were enriched by sucrose gradient centrifugation from postmortem brains, and a negative control sample was prepared from specimen without LB pathology. Whereas approximately 550 proteins were identified in the LB-enriched sample by mass spectrometry, quantitative comparison with the control sample revealed that approximately 40 proteins were co-enriched with alpha-synuclein, the major component in Lewy bodies. As expected, the list of proteins included previously reported constituents, such as those involved in protein folding, membrane trafficking and oxidative stress. More interestingly, we discovered in the LB-enriched sample several kinases (MAPKK1/MEK1, protein kinase C, and doublecortin-like kinase), a novel deubiquitinating enzyme (otubain 1), and numerous ubiquitin ligases (KPC and SCF). The proteomic studies provide enzyme candidates to investigate the regulation of alpha-synuclein and/or other LB proteins, which may contribute to the formation of Lewy bodies and the toxicity of alpha-synuclein in the related neurodegenerative disorders.", "neg": "A central feature of Alzheimer's disease is the cleavage of the amyloid precursor protein (APP) to form beta-amyloid peptide (Abeta) by the beta-secretase and gamma-secretase enzymes. Although this has been shown to occur after endocytosis of APP from the cell surface, the exact compartments of APP processing are not well defined. We have previously demonstrated that APP and gamma-secretase proteins and activity are highly enriched in purified rat liver lysosomes. In order to examine the lysosomal distribution and trafficking of APP in cultured cells, we generated constructs containing APP fused to a C-terminal fluorescent protein tag and N-terminal HA-epitope tag. These were co-transfected with a panel of fluorescent-protein tagged compartment markers. Here we demonstrate using laser-scanning confocal microscopy that although APP is present throughout the endosomal/lysosomal system in transfected Cos7 and neuronal SN56 cell lines as well as in immunostained cultured mouse neurons, it is enriched in the lysosome. We also show that the Swedish and London mutations reduce the amount of APP in the lysosome. Surprisingly, in addition to its expected trafficking from the cell surface to the early and then late endosomes, we find that cell-surface labelled APP is transported rapidly and directly from the cell surface to lysosomes in both Cos7 and SN56 cells. This rapid transit to the lysosome is blocked by the presence of either the London or Swedish mutations. These results demonstrate the presence of a novel, rapid and specific transport pathway from the cell surface to the lysosomes. This suggests that regulation of lysosomal traffic could regulate APP processing and that the lysosome could play a central role in the pathophysiology of Alzheimer's disease.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}387{"query": "After the 2004 Asian tsunami disaster, four independent volunteers, with little money and no experience, race off to volunteer in tsunami ravaged Sri Lanka. They meet up by fate at the Colombo airport and form a volunteer team. They rent a van, fill it with supplies and start driving down the coast to see where they can help. They stumble into a tribal village called Peraliya, which has been destroyed by a forty foot wave. During the time the wave hit Peraliya, a train called \"The Queen of the Sea\" was passing by and was washed away killing over 2500 passengers and villagers. The Four volunteers set up a first aid station and found themselves in charge of running a refugee camp with over 3000 people. Their initial two week journey turns into a year long odyssey of heartbreak and hope as the villagers turn against them when donated tsunami relief money does not materialize. The volunteers concentrate on the bigger picture and break every rule in the 'Disaster Aid Books'.", "pos": "Tsunami are deadly ocean waves from the sharp jolt of an undersea earthquake. Less frequently, these waves can be generated by other shocks to the sea, like a meteorite impact. Fortunately, few undersea earthquakes, and even fewer meteorite impacts, generate tsunami. Tsunami waves have small wave heights relative to their long wavelengths, so they are usually unnoticed at sea. When traveling up a slope onto a shoreline, the wave is pushed upward. As with wind waves, the speed of the bottom of the wave is slowed by friction. This causes the wavelength to decrease and the wave to become unstable. These factors can create an enormous and deadly wave. Landslides, meteorite impacts, or any other jolt to ocean water may form a tsunami. Tsunami can travel at speeds of 800 kilometers per hour (500 miles per hour). Since tsunami are long-wavelength waves, a long time can pass between crests or troughs. Any part of the wave can make landfall first. In 1755 in Lisbon, Portugal, a tsunami trough hit land first. A large offshore earthquake did a great deal of damage on land. People rushed out to the open space of the shore. Once there, they discovered that the water was flowing seaward fast and some of them went out to observe. What do you think happened next? The people on the open beach drowned when the crest of the wave came up the beach. Large tsunami in the Indian Ocean and more recently Japan have killed hundreds of thousands of people in recent years. The west coast is vulnerable to tsunami since it sits on the Pacific Ring of Fire. Scientists are trying to learn everything they can about predicting tsunamis before a massive one strikes a little closer to home. Although most places around the Indian Ocean did not have warning systems in 2005, there is a tsunami warning system in that region now. Tsunami warning systems have been placed in most locations where tsunami are possible. Click image to the left or use the URL below. URL:", "neg": "Not everyone had the same warning the people on Tillys beach had. The Boxing Day Tsunami of December 26, 2004 was by far the deadliest of all time (Figure 1.1). The tsunami was caused by the 2004 Indian Ocean Earthquake. With a magnitude of 9.2, it was the second largest earthquake ever recorded. The extreme movement of the crust displaced trillions of tons of water along the entire length of the rupture. Several tsunami waves were created with about 30 minutes between the peaks of each one. The waves that struck nearby Sumatra 15 minutes after the quake reached more than 10 meters (33 feet) in height. The size of the waves decreased with distance from the earthquake and were about 4 meters (13 feet) high in Somalia. The tsunami did so much damage because it traveled throughout the Indian Ocean. About 230,000 people died in eight countries. There were fatalities even as far away as South Africa, nearly 8,000 kilometers (5,000 miles) from the earthquake epicenter. More than 1.2 million people lost their homes and many more lost their ways of making a living. The countries that were most affected by the 2004 Boxing Day tsunami. The Japanese received a one-two punch in March 2011. The 2011 Tohoku earthquake offshore was a magnitude 9.0 and damage from the quake was extensive. People didnt have time to recover before massive tsunami waves hit the island nation. As seen in Figure 1.2, waves in some regions topped 9 meters (27 feet). The tsunami did much more damage than the massive earthquake (Figure 1.3). Worst was the damage done to nuclear power plants along the northeastern coast. Eleven reactors were automatically shut down. Power and backup power were lost at the Fukushima plant, leading to equipment failures, meltdowns, and the release of radioactive materials. Control and cleanup of the disabled plants will go on for many years. As a result of the 2004 tsunami, an Indian Ocean warning system was put into operation in June 2006. Prior to 2004, no one had thought a large tsunami was possible in the Indian Ocean. In comparison, a warning system has been in effect around the Pacific Ocean for more than 50 years. The system was used to warn of possible tsunami waves after the Tohoku earthquake, but most were too close to the quake to get to high ground in time. Further away, people were evacuated along many Pacific coastlines, but the waves were not that large.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}388{"query": "The general Chinese history texts on the Ming Dynasty, including the Mingdai Shi and the Mingshi, briefly mention Cao Qin's failed coup of 1461. Cao Qin's coup and the events leading up to it were covered in Gao Dai's Hong you lu of 1573, Jiao Hong's Guochao Xianzheng lu of 1594-1616, the Huang Ming shi gai of 1632 and the Mingshi jishi benmo of 1658. Li Xian also wrote about Cao Jixiang's career in his \"Cao Jixiang zhi bian,\" featured in the Huang Ming mingchen jingji lu that was edited by Huang Xun in 1551.", "pos": "After the defeat of several Song armies in the north, Emperor Qinzong wanted to negotiate a truce with the Jin, but he committed a massive strategic blunder when he commanded his remaining armies to protect prefectural cities instead of Kaifeng. Neglecting the importance of the capital, he left Kaifeng defended with fewer than 100,000 soldiers. The Song forces were dispersed throughout China, powerless to stop the second Jurchen siege of the city. The Jin assault commenced in mid December 1126. Even as fighting raged on, Qinzong continued to sue for peace, but Jin demands for territory were enormous: they wanted all provinces north of the Yellow River. After more than twenty days of heavy combat against the besieging forces, Song defenses were decimated and the morale of Song soldiers was on the decline. On January 9, 1127, the Jurchens broke through and started to loot the conquered city. Emperor Qinzong tried to appease the victors by offering the remaining wealth of the capital. The royal treasury was emptied and the belongings of the city's residents were seized. The Song emperor offered his unconditional surrender a few days later. Qinzong, the former emperor Huizong, and members of the Song court were captured by the Jurchens as hostages. They were taken north to Huining , where they were stripped of their royal privileges and reduced to commoners. The former emperors were humiliated by their captors. They were mocked with disparaging titles like \"Muddled Virtue\" and \"Double Muddled\". In 1128 the Jin made them perform a ritual meant for war criminals. The harsh treatment of the Song royalty softened after the death of Huizong in 1135. Titles were granted to the deceased monarch, and his son Qinzong was promoted to Duke, a position with a salary.", "neg": "Si Renfa's son Si Jifa escaped and continued independent action in another corner of southwest Yunnan. He sent his younger brother Zhaosai to seek pardon from Ming while at the same time he attacked Ming troops in early 1443. However they were defeated and he was forced to flee to Mong Yang. Zhaosai was kept as a hostage and the Ming retreated from Mong Mao. Seeing that Mong Mao was no longer occupied, Si Jifa returned to his father's base of power and began attacking neighboring tribes once again. The third punitive expedition was led by Wang Ji and launched in March 1443. Although the mission was to capture Si Jifa, negotiations on the return of Si Renfa had fallen ill. Ava demanded Ming territory for itself and Hsenwi in return of Si Renfa. Furthermore Ava had made peace with Si Jifa. Therefore, although the Ming army quickly defeated Si Jifa's base of power and captured his family, Si Jifa managed to escape to Mong Yang, and the Ming army decided not to pursue out of consideration of a combined Ava-Hsenwi attack on Ming forces. A compromise was finally reached between Ava and Ming in April 1445. Ava agreed to hand over Si Renfa in return for Ming support in annexing part of Hsenwi's territory. Si Renfa came into Ming custody in August 1445 and was executed in January 1446.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}389{"query": "An infectious disease is a disease that is caused by a pathogen. A pathogen is an organism or virus that causes disease in another living thing. Pathogens are commonly called germs. Watch this dramatic video for an historic perspective on infectious diseases and their causes: . MEDIA Click image to the left or use the URL below. URL: There are several types of pathogens that cause diseases in human beings. They include bacteria, viruses, fungi, and protozoa. The different types are described in Table 21.1. The table also lists several diseases caused by each type of pathogen. Many infectious diseases caused by these pathogens can be cured with medicines. For example, antibiotic drugs can cure most diseases caused by bacteria. Different pathogens spread in different ways. Some are easy to catch. Others are much less contagious. Some pathogens spread through food or water. When harmful bacteria contaminate food, they cause foodborne illness, commonly called food poisoning. An example of a pathogen that spreads through water is the protozoan named Giardia lamblia, described in Table 21.1. It causes a disease called giardiasis. Some pathogens spread through sexual contact. In the U.S., the pathogen most commonly spread this way is HPV, or human papillomavirus. It may cause genital warts and certain types of cancer. A vaccine can prevent the spread of this pathogen. Many pathogens spread by droplets in the air. Droplets are released when a person coughs or sneezes, as you can see in Figure 21.2. The droplets may be loaded with pathogens. Other people may get sick if they breathe in the pathogens on the droplets. Viruses that cause colds and flu can spread this way. Other pathogens spread when they are deposited on objects or surfaces. The fungus that causes athletes food spreads this way. For example, you might pick up the fungus from the floor of a public shower. You can also pick up viruses for colds and flu from doorknobs and other commonly touched surfaces. Still other pathogens are spread by vectors. A vector is an organism that carries pathogens from one person or animal to another. Most vectors are insects such as ticks or mosquitoes. They pick up pathogens when they bite an infected animal and then transmit the pathogens to the next animal they bite. Ticks spread the bacteria that cause Lyme disease. Mosquitoes spread the protozoa that cause malaria. What can you do to avoid infectious diseases? Eating well and getting plenty of sleep are a good start. These habits will help keep your immune system healthy. With a healthy immune system, you will be able to fight off many pathogens. Vaccines are available for some infectious diseases. For example, there are vaccines to prevent measles, mumps, whooping cough, and chicken pox. These vaccines are recommended for infants and young children. You can also take the following steps to avoid picking up pathogens or spreading them to others. Watch this video for additional information on preventing the spread of infectious diseases: MEDIA Click image to the left or use the URL below. URL: Wash your hands often with soap and water. Spend at least 20 seconds scrubbing with soap. See Figure 21.3 for effective hand washing tips. Avoid touching your eyes, nose, or mouth with unwashed hands. Avoid close contact with people who are sick. This includes kissing, hugging, shaking hands, and sharing cups or eating utensils. Cover your coughs and sneezes with a tissue or shirt sleeve, not your hands. Disinfect frequently touched surfaces, such as keyboards and doorknobs, especially if someone is sick. Stay home when you are sick. The best way to prevent diseases spread by vectors is to avoid contact with the vectors. For example, you can wear long sleeves and long pants to avoid tick and mosquito bites. Using insect repellent can also reduce your risk of insect bites.", "pos": "With so many species of bacteria, some are bound to be harmful. Harmful bacteria can make you sick. They can also ruin food and be used to hurt people. There are also ways that bacteria can be harmful to humans and other animals. Bacteria are responsible for many types of human illness ( Figure 1.1), including: Strep throat Tuberculosis Pneumonia Leprosy Lyme disease Luckily most of these can be treated with antibiotics, which kill the bacteria. It is important that when a medical doctor prescribes antibiotics for you, you take the medicine exactly as the doctor tells you. You need to make sure the bacteria is killed. Bacterial contamination of foods can lead to digestive problems, an illness known as food poisoning. Raw eggs and undercooked meats commonly carry the bacteria that can cause food poisoning. Food poisoning can be prevented by cooking meat thoroughly, which kills most microbes, and washing surfaces that have been in contact with raw meat. Washing your hands before and after handling food also helps prevent contamination. Some bacteria also have the potential to be used as biological weapons by terrorists. An example is anthrax, a disease caused by the bacterium Bacillus anthracis. Inhaling the spores of this bacterium can lead to a deadly infection, and, therefore, it is a dangerous weapon. In 2001, an act of terrorism in the United States involved B. anthracis spores sent in letters through the mail. KidsHealth Food Poisoning at [Link] . 1. What are the common bacteria that cause food poisoning? 2. What steps can you take to keep your food safe?", "neg": "The nervous system controls sensing, feeling, and thinking. It also controls movement and just about every other body function. Thats why problems with the nervous system can affect the entire body. Diseases of the nervous system include brain and spinal cord infections. Other problems of the nervous system range from very serious diseases, such as tumors, to less serious problems, such as tension headaches. Some of these diseases are present at birth. Others begin during childhood or adulthood. When you think of infections, you probably think of an ear infection or strep throat. You probably dont think of a brain or spinal cord infection. But bacteria and viruses can infect these organs as well as other parts of the body. Infections of the brain and spinal cord are not very common. But when they happen, they can be very serious. Thats why its important to know their symptoms. Encephalitis is a brain infection ( Figure 1.1). If you have encephalitis, you are likely to have a fever and headache or feel drowsy and confused. The disease is most often caused by viruses. The immune system tries to fight off a brain infection, just as it tries to fight off other infections. But sometimes this can do more harm than good. The immune systems response may cause swelling in the brain. With no room to expand, the brain pushes against the skull. This may injure the brain and even cause death. Medicines can help fight some viral infections of the brain, but not all infections. Meningitis is an infection of the membranes that cover the brain and spinal cord. If you have meningitis, you are likely to have a fever and a headache. Another telltale symptom is a stiff neck. Meningitis can be caused by viruses or bacteria. Viral meningitis often clears up on its own after a few days. Bacterial meningitis is much more serious ( Figure 1.2). It may cause brain damage and death. People with bacterial meningitis need emergency medical treatment. They are usually given antibiotics to kill the bacteria. A vaccine to prevent meningitis recently became available. It can be given to children as young as two years old. Many doctors recommend that children receive the vaccine no later than age 12 or 13, or before they begin high school. A condition called Reyes syndrome can occur in young people that take aspirin when they have a viral infection. The syndrome causes swelling of the brain and may be fatal. Fortunately, Reyes syndrome is very rare. The best way to prevent it is by not taking aspirin when you have a viral infection. Products like cold medicines often contain aspirin. So, read labels carefully when taking any medicines ( Figure 1.3). Since 1988, the U.S. Food and Drug Ad- ministration has required that all aspirin and aspirin-containing products carry a warning about Reyes syndrome. Like other parts of the body, the nervous system may develop tumors. A tumor is a mass of cells that grows out of control. A tumor in the brain may press on normal brain tissues. This can cause headaches, difficulty speaking, or other problems, depending on where the tumor is located. Pressure from a tumor can even cause permanent brain damage. In many cases, brain tumors can be removed with surgery. In other cases, tumors cant be removed without damaging the brain even more. In those cases, other types of treatments may be needed. Cerebral palsy is a disease caused by injury to the developing brain. The injury occurs before, during, or shortly after birth. Cerebral palsy is more common in babies that have a low weight at birth. But the cause of the brain injury is not often known. The disease usually affects the parts of the brain that control body movements. Symptoms range from weak muscles in mild cases to trouble walking and talking in more severe cases. There is no known cure for cerebral palsy. Epilepsy is a disease that causes seizures. A seizure is a period of lost consciousness that may include violent muscle contractions. It is caused by abnormal electrical activity in the brain. The cause of epilepsy may be an infection, a brain injury, or a tumor", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}390{"query": "When two or more waves meet, they interact with each other. The interaction of waves with other waves is called wave interference. Wave interference may occur when two waves that are traveling in opposite directions meet. The two waves pass through each other, and this affects their amplitude. Amplitude is the maximum distance the particles of the medium move from their resting positions when a wave passes through. How amplitude is affected by wave interference depends on the type of interference. Interference can be constructive or destructive. Constructive interference occurs when the crests, or highest points, of one wave overlap the crests of the other wave. You can see this in the Figure 1.1. As the waves pass through each other, the crests combine to produce a wave with greater amplitude. Destructive interference occurs when the crests of one wave overlap the troughs, or lowest points, of another wave. The Figure 1.2 shows what happens. As the waves pass through each other, the crests and troughs cancel each other out to produce a wave with zero amplitude. Waves may reflect off an obstacle that they are unable to pass through. When waves are reflected straight back from an obstacle, the reflected waves interfere with the original waves and create standing waves. These are waves that appear to be standing still. Standing waves occur because of a combination of constructive and destructive interference. Q: How could you use a rope to produce standing waves? A: You could tie one end of the rope to a fixed object, such as doorknob, and move the other end up and down to generate waves in the rope. When the waves reach the fixed object, they are reflected back. The original waves and the reflected waves interfere to produce a standing wave. Try it yourself and see if the waves appear to stand still.", "pos": "A mechanical wave is a disturbance in matter that transfers energy from place to place. A mechanical wave starts when matter is disturbed. An example of a mechanical wave is pictured in Figure 19.1. A drop of water falls into a pond. This disturbs the water in the pond. What happens next? The disturbance travels outward from the drop in all directions. This is the wave. A source of energy is needed to start a mechanical wave. In this case, the energy comes from the falling drop of water. The energy of a mechanical wave can travel only through matter. This matter is called the medium (plural, media). The medium in Figure 19.1 is a liquid the water in the pond. But the medium of a mechanical wave can be any state of matter, including a solid or a gas. Its important to note that particles of matter in the medium dont actually travel along with the wave. Only the energy travels. The particles of the medium just vibrate, or move back-and- forth or up-and-down in one spot, always returning to their original positions. As the particles vibrate, they pass the energy of the disturbance to the particles next to them, which pass the energy to the particles next to them, and so on. There are three types of mechanical waves. They differ in how they travel through a medium. The three types are transverse, longitudinal, and surface waves. All three types are described in detail below. A transverse wave is a wave in which the medium vibrates at right angles to the direction that the wave travels. An example of a transverse wave is a wave in a rope, like the one pictured in Figure 19.2. In this wave, energy is provided by a persons hand moving one end of the rope up and down. The direction of the wave is down the length of the rope away from the persons hand. The rope itself moves up and down as the wave passes through it. You can see a brief video of a transverse wave in a rope at this URL: . To see a transverse wave in slow motion, go to this URL: (0:22). MEDIA Click image to the left or use the URL below. URL: A transverse wave can be characterized by the high and low points reached by particles of the medium as the wave passes through. This is illustrated in Figure 19.3. The high points are called crests, and the low points are called troughs. Another example of transverse waves occurs with earthquakes. The disturbance that causes an earthquake sends transverse waves through underground rocks in all directions from the disturbance. Earthquake waves that travel this way are called secondary, or S, waves. An S wave is illustrated in Figure 19.4. A longitudinal wave is a wave in which the medium vibrates in the same direction that the wave travels. An example of a longitudinal wave is a wave in a spring, like the one in Figure 19.5. In this wave, the energy is provided by a persons hand pushing and pulling the spring. The coils of the spring first crowd closer together and then spread farther apart as the disturbance passes through them. The direction of the wave is down the length of the spring, or the same direction in which the coils move. You can see a video of a longitudinal wave in a spring at this URL: http A longitudinal wave can be characterized by the compressions and rarefactions of the medium. This is illustrated in Figure 19.6. Compressions are the places where the coils are crowded together, and rarefactions are the places where the coils are spread apart. Earthquakes cause longitudinal waves as well as transverse waves. The disturbance that causes an earthquake sends longitudinal waves through underground rocks in all directions from the disturbance. Earthquake waves that travel this way are called primary, or P, waves. They are illustrated in Figure 19.7. A surface wave is a wave that travels along the surface of a medium. It combines a transverse wave and a longitudinal wave. Ocean waves are surface waves. They travel on the surface of the water between the ocean", "neg": "Wave speed is the distance a wave travels in a given amount of time, such as the number of meters it travels per second. Wave speed (and speed in general) can be represented by the equation: Speed = Distance Time Wave speed is related to both wavelength and wave frequency. Wavelength is the distance between two correspond- ing points on adjacent waves. Wave frequency is the number of waves that pass a fixed point in a given amount of time. This equation shows how the three factors are related: Speed = Wavelength x Wave Frequency In this equation, wavelength is measured in meters and frequency is measured in hertz (Hz), or number of waves per second. Therefore, wave speed is given in meters per second, which is the SI unit for speed. Q: If you increase the wavelength of a wave, does the speed of the wave increase as well? A: Increasing the wavelength of a wave doesnt change its speed. Thats because when wavelength increases, wave frequency decreases. As a result, the product of wavelength and wave frequency is still the same speed. Click image to the left or use the URL below. URL: The equation for wave speed can be used to calculate the speed of a wave when both wavelength and wave frequency are known. Consider an ocean wave with a wavelength of 3 meters and a frequency of 1 hertz. The speed of the wave is: Speed = 3 m x 1 wave/s = 3 m/s Q: Kim made a wave in a spring by pushing and pulling on one end. The wavelength is 0.1 m, and the wave frequency is 2 hertz. What is the speed of the wave? A: Substitute these values into the equation for speed: Speed = 0.1 m x 2 waves/s = 0.2 m/s The equation for wave speed (above) can be rewritten as: Frequency = Speed Wavelength or Wavelength = Speed Frequency Therefore, if you know the speed of a wave and either the wavelength or wave frequency, you can calculate the missing value. For example, suppose that a wave is traveling at a speed of 2 meters per second and has a wavelength of 1 meter. Then the frequency of the wave is: Frequency = 2m/s 1m = 2 waves/s, or 2 Hz Q: A wave is traveling at a speed of 2 m/s and has a frequency of 2 Hz. What is its wavelength? A: Substitute these values into the equation for wavelength: Wavelength = 2m/s 2waves/s =1m The speed of most waves depends on the medium, or the matter through which the waves are traveling. Generally, waves travel fastest through solids and slowest through gases. Thats because particles are closest together in solids and farthest apart in gases. When particles are farther apart, it takes longer for the energy of the disturbance to pass from particle to particle through the medium. Click image to the left or use the URL below. URL:", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}391{"query": "Jim Honeyford (born January 24, 1939) is an American politician of the Republican Party.", "pos": "Redfield Proctor (June 1, 1831 -- March 4, 1908) was a U.S. politician of the Republican Party.", "neg": "Desperate Journey is a 1942 American World War II action and aviation film starring Errol Flynn and Ronald Reagan, directed by Raoul Walsh.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}392{"query": "To understand what satellites can do, lets look at an example. One of the deadliest hurricanes in United States history hit Galveston, Texas in 1900. The storm was first spotted at sea on Monday, August 27th , 1900. It was a tropical storm when it hit Cuba on September 3rd . By September 8th , it had intensified to a hurricane over the Gulf of Mexico. It came ashore at Galveston (Figure 2.34). Because there was not advanced warning, more than 8000 people lost their lives. Today, we have satellites with many different types of instruments that orbit the Earth. With these satellites, satellites can see hurricanes form at sea. They can follow hurricanes as they move from far out in the oceans to shore. Weather forecasters can warn people who live along the coasts. These advanced warning give people time to prepare for the storm. They can find a safe place or even evacuate the area, which helps save lives. Satellites orbit high above the Earth in several ways. Different orbits are important for viewing different things about the planet. A satellite in a geostationary orbit flies above the planet at a distance of 36,000 km. It takes 24 hours to complete one orbit. The satellite and the Earth both complete one rotation in 24 hours. This means that the satellite stays over the same spot. Weather satellites use this type of orbit to observe changing weather conditions over a region. Communications satellites, like satellite TV, use this type of orbit to keep communications going full time. Another useful orbit is the polar orbit (Figure 2.35). The satellite orbits at a distance of several hundred kilometers. It makes one complete orbit around the Earth from the North Pole to the South Pole about every 90 minutes. In this same amount of time, the Earth rotates only slightly underneath the satellite. So in less than a day, the satellite can see the entire surface of the Earth. Some weather satellites use a polar orbit to see how the weather is changing globally. Also, some satellites that observe the land and oceans use a polar orbit. The National Aeronautics and Space Administration (NASA) has launched a fleet of satellites to study the Earth (Figure 2.36). The satellites are operated by several government agencies, including NASA, the National Oceano- graphic and Atmospheric Administration (NOAA), and the United States Geological Survey (USGS). By using different types of scientific instruments, satellites make many kinds of measurements of the Earth. Some satellites measure the temperatures of the land and oceans. Some record amounts of gases in the atmosphere, such as water vapor and carbon dioxide. Some measure their height above the oceans very precisely. From this information, they can measure sea level. Some measure the ability of the surface to reflect various colors of light. This information tells us about plant life. Some examples of the images from these types of satellites are shown in Figure 2.37. In order to locate your position on a map, you must know your latitude and your longitude. But you need several instruments to measure latitude and longitude. What if you could do the same thing with only one instrument? Satellites can also help you locate your position on the Earths surface. By 1993, the United States military had launched 24 satellites to help soldiers locate their positions on battlefields. This system of satellites was called the Global Positioning System (GPS). Later, the United States government allowed the public to use this system. Heres how it works. You must have a GPS receiver to use the system (Figure 2.38). You can buy many types of these in stores. The Prior to the late 20th and early 21st centuries, mapmakers sent people out in the field to determine the boundaries and locations for various features for maps. State or county borders were used to mark geological features. Today, people in the field use GPS receivers to mark the locations of features. Map-makers also use various satellite images and computers to draw maps. Computers are able to break apart the fine details of a satellite image, store the pieces of information, and put them back together to make a map.", "pos": "Figure 1.1 shows the relative sizes of the orbits of the planets, asteroid belt, and Kuiper belt. In general, the farther away from the Sun, the greater the distance from one planets orbit to the next. The orbits of the planets are not circular but slightly elliptical, with the Sun located at one of the foci (see opening image). While studying the solar system, Johannes Kepler discovered the relationship between the time it takes a planet to make one complete orbit around the Sun, its \"orbital period,\" and the distance from the Sun to the planet. If the orbital period of a planet is known, then it is possible to determine the planets distance from the Sun. This is how astronomers without modern telescopes could determine the distances to other planets within the solar system. How old are you on Earth? How old would you be if you lived on Jupiter? How many days is it until your birthday on Earth? How many days until your birthday if you lived on Saturn? Click image to the left or use the URL below. URL: The relative sizes of the orbits of planets in the solar system. The inner solar sys- tem and asteroid belt is on the upper left. The upper right shows the outer planets and the Kuiper belt.", "neg": "BEIJING - Astronomers have defended against rumors that the terrible earthquake and the following tsunami in Japan were closely related to or even caused by the \"supermoon\" that will appear in the sky on Saturday. The word \"supermoon\" was introduced in a report by the British newspaper Daily Mail on March 9, which said amateur scientists were warning that such an astronomical phenomenon could disturb the Earth's climate patterns and may even cause earthquakes and volcanic activity. The moon will be 356,577 kilometers from the Earth on Saturday, the closest in 19 years, and the closest point in its oval orbit coincides with a full moon, the report said. However, Saturday's moon is not actually the closest to Earth in 19 years, Tang Haiming, an astronomer with Shanghai Astronomical Observatory under the Chinese Academy of Sciences, told Xinhua News Agency. A shorter distance of 356,570 km between the two bodies was reached in January 2005, and a distance of 356,566 km was seen in December 2008. Yet some people suggest that previous supermoons have occurred prior to extreme weather events. In 1974 the phenomenon was followed by Cyclone Tracy in Darwin, Australia, and in 2005 it occurred shortly before a deadly tsunami in Indonesia. Coincidentally, two fresh disasters happened in Asia right before Saturday's supermoon. The public's concern about their connection with the moon boomed after Japan's terrible earthquake and tsunami and an earthquake in Southwest China's Yunnan province that killed 25 people on March 10. But astronomers are trying to _ people that such rumors are merely unreasonable. \"A supermoon could cause high tides but has no direct relation with natural disasters such as earthquakes,\" Liu Jie, a researcher with the China Earthquake Network Center, told China Daily on Tuesday. \"We can't find any necessary connection between previous supermoons and earthquakes. And the quake in Japan occurred because the Earth's inner energy had accumulated to some extent, and it's not related to the moon. \" he said. James Garvin, chief scientist at the Goddard Space Flight Center under NASA, said in an article on NASA's website that \"the effects on Earth from a supermoon are minor.\"\"The combination of the moon being at its closest to Earth in its orbit, and being in its 'full moon' configuration ( to the Earth and sun), should not affect the inner energy balance of the Earth, since there are lunar tides every day. \" Zhu Jin, curator of the Beijing Planetarium, said\"the moon moves around the earth in a certain path, so each orbit has a perigee - its closest approach, and an apogee - its furthest distance.\"\"A lunar perigee occurs once a month and there are very small differences in distances between perigees,\"he said.\"Those tiny differences are far from enough to cause earthquakes or eruption of a volcano,\"he added.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}393{"query": "The inflammatory cytokine IL-1 has an essential role in the innate immune response. High levels of IL-1 have been implicated in the development of many diseases, including type 1 and 2 diabetes (T1D and T2D), rheumatoid arthritis (RA) and cardiovascular disease. XOMA is developing gevokizumab (XOMA-052), an IgG2 humanized mAb against human IL-1, for the potential treatment of these diseases. Gevokizumab has a high affinity for IL-1 and a long t1/2, which would allow for once-monthly dosing and offer a considerable advantage for patients over agents requiring more frequent dosing. Data from preclinical studies and clinical trials suggest that gevokizumab is a potentially effective and well-tolerated treatment for the indicated diseases. At the time of publication, phase II clinical trials were ongoing in patients with T1D, T2D and RA, with the T2D trials assessing key cardiovascular markers. Following promising data from a recent pilot trial, XOMA was also planning a phase I/II trial of gevokizumab for the potential treatment of uveitis in patients with the vasculitic inflammatory disorder Behcet's disease and the autoinflammatory conditions familial cold autoinflammatory syndrome and Muckle-Wells syndrome.", "pos": "Insulin is the cornerstone of type 1 diabetes mellitus (T1DM) therapy. However, it cannot achieve a delay in the onset or evolution of this condition, while cardiovascular morbidity remains an unquestionable threat. In this review, the authors discuss gevokizumab (XOMA 052), a recombinant monoclonal antibody that can neutralize human IL-1 by binding to it. This is relevant, because this IL has been associated with -cell toxicity in both diabetes types. Moreover, gevokizumab presents two major advantages: it spares IL-1 and it exhibits favorable pharmacokinetic properties. Gevokizumab has already proven its safety and efficacy in improving glycemic control, cell function and inflammation markers in clinical trials in diabetic patients. Despite the very promising characteristics of gevokizumab, important questions remain to be answered. One important question is what to expect from a combination of this agent with insulin and if there is a subset of patients that might respond more favorably to treatment. We also need to know at what stage in the natural history of T1DM could gevokizumab be most efficacious, as well as its potential effects on cardiovascular outcomes.", "neg": "Ghrelin exhibits its biological effect through binding to the growth hormone secretagogue 1a receptor (GHS-R1a). Recently, it has been reported that ghrelin has an anti-apoptotic effect in several cell types. However, the molecule mechanisms underlying the anti-apoptotic effect of ghrelin remain poorly understood. In this study, we investigated the intracellular mechanisms responsible for anti-apoptotic effect of ghrelin on human umbilical vein endothelial cells (HUVEC). Treatment of HUVEC with ghrelin inhibited high glucose-induced cell apoptosis. Ghrelin stimulated the rapid phosphorylation of mammalian target of rapamycin (mTOR), P70S6K and S6. The GHS-R1a-specific antagonist [D-Lys3]-GHRP-6 abolished the anti-apoptotic effect and inhibited the activation of mTOR, P70S6K, S6 induced by ghrelin. Pretreatment of cells with specific inhibitor of mTOR blocked the anti-apoptotic effect of ghrelin. In addition, ghrelin protected HUVECs against high glucose induced apoptosis by increasing Bcl-2/Bax ratio. Taken together, our results demonstrate that ghrelin produces a protective effect on HUVECs through activating GHS-R1a and mTOR/P70S6K signaling pathway mediates the effect of ghrelin. These observations suggest that ghrelin may act as a survival factor in preventing HUVECs apoptosis caused by high glucose.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}394{"query": "The Battle of Munchengratz (German: Schlacht bei Munchengratz) or Battle of Mnichovo Hradiste (Czech: Bitva u Mnichova Hradiste) was fought near Mnichovo Hradiste, modern day Czech Republic, on 28 June 1866 during the Austro-Prussian War.", "pos": "The Battle of Maysalun (Arabic: ), also called the Battle of Maysalun Pass, was a battle fought between the forces of the Arab Kingdom of Syria and French Army of the Levant on 24 July 1920 near the Maysalun Pass, about 12 miles west of Damascus, close to the Lebanese border.", "neg": "Chopiatyn (xwpjatn) is a village in the administrative district of Gmina Dohobyczow, within Hrubieszow County, Lublin Voivodeship, in eastern Poland, close to the border with Ukraine.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}395{"query": "The Vikings' eleventh game was an NFC duel with the Redskins at FedExField. In the 1st quarter the Vikings trailed early as QB Donovan McNabb completed a 10-yard TD pass to TE Fred Davis. They replied as RB Adrian Peterson got a 5-yard TD run. The Vikings pulled ahead with RB Toby Gerhart getting a 5-yard TD run, followed by kicker Ryan Longwell nailing a 31-yard field goal. The Redskins tried to come back, but only came away with 40-yard and a 42-yard field goals from kicker Graham Gano, giving the Vikings the win.", "pos": "Coming off their Monday night road win over the Saints, the Vikings went home for a Week 6 NFC North duel with the Detroit Lions. In the first quarter, the Vikes got an early lead as Lions QB Dan Orlovsky unintentionally ran out of the back of his own end zone, giving Minnesota a safety which Orlovsky didn't know why the whistles were blown. In the second quarter, Detroit got the lead as kicker Jason Hanson got a 40-yard field goal. In the third quarter, the Lions increased their lead as Orlovsky completed a 12-yard TD pass to WR Calvin Johnson. The Vikings answered with QB Gus Frerotte completing an 86-yard TD pass to WR Bernard Berrian. In the end of the fourth quarter, the Vikes got in field goal range due to a controversial pass interference call on Leigh Bodden. The Vikes sealed the win with kicker Ryan Longwell nailing the game-winning 26-yard field goal.", "neg": "This game is well known for an infamous penalty that occurred during the overtime period. The Jets were lining up for a game winning 56-yard field goal in overtime to try and give them the win. Nick folk kicked the ball, but the kick went wide right and the Patriots appeared to be taking over with a chance to win. However, Chris Jones of New England was called for a controversial unsportsmanlike conduct penalty after pushing his teammate into the offensive line. This penalty would later be named \"leaping\". The penalty gave the Jets another chance and made the field goal attempt a 51-yard attempt. This time, Folk drilled the kick, and the Jets would go on to stun the Patriots. With the win, the Jets improved to 4-3.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}396{"query": "You are on vacation at the beach. You take your flip-flops off so you can go swimming. The sand is so hot it hurts your feet. You have to run to the water. Now imagine if it were hot enough for the sand to melt. Some places inside Earth are so hot that rock melts. Melted rock inside the Earth is called magma. Magma can be hotter than 1,000C. When magma erupts onto Earths surface, it is known as lava, as Figure 3.17 shows. Minerals form when magma and lava cool. Most water on Earth, like the water in the oceans, contains elements. The elements are mixed evenly through the water. Water plus other substances makes a solution. The particles are so small that they will not come out when you filter the water. But the elements in water can form solid mineral deposits. Fresh water contains a small amount of dissolved elements. Salt water contains a lot more dissolved elements. Water can only hold a certain amount of dissolved substances. When the water evaporates, it leaves behind a solid layer of minerals, as Figure 3.18 shows. At this time, the particles come together to form minerals. These solids sink to the bottom. The amount of mineral formed is the same as the amount dissolved in the water. Seawater is salty enough for minerals to precipitate as solids. Some lakes, such as Mono Lake in California, or Utahs Great Salt Lake, can also precipitate salts. Salt easily precipitates out of water, as does calcite, as Figure 3.19 shows. The limestone towers in the figure are made mostly of the mineral calcite. The calcite was deposited in the salty and alkaline water of Mono Lake, in California. Calcium-rich spring water enters the bottom of the lake. The water bubbles up into the alkaline lake. The Underground water can be heated by magma. The hot water moves through cracks below Earths surface. Hot water can hold more dissolved particles than cold water. The hot, salty solution has chemical reactions with the rocks around it. The water picks up more dissolved particles. As it flows through open spaces in rocks, the water deposits solid minerals. When a mineral fills cracks in rocks, the deposits are called veins. Figure 3.20 shows a white quartz vein. When the minerals are deposited in open spaces, large crystals grow. These rocks are called geodes. Figure 3.20 shows a geode that was formed when amethyst crystals grew in an open space in a rock.", "pos": "Earths outer surface is its crust, a cold, thin, brittle outer shell made of rock. The crust is very thin relative to the radius of the planet. There are two very different types of crust, each with its own distinctive physical and chemical properties, which are summarized in Table 1.1. Crust Oceanic Continental Thickness 5-12 km (3-8 mi) Avg. 35 km (22 mi) Density 3.0 g/cm3 2.7 g/cm3 Composition Mafic Felsic Rock types Basalt and gabbro All types Oceanic crust is composed of mafic magma that erupts on the seafloor to create basalt lava flows or cools deeper down to create the intrusive igneous rock gabbro (Figure 1.1). Gabbro from ocean crust. The gabbro is deformed because of intense faulting at the eruption site. Sediments, primarily mud and the shells of tiny sea creatures, coat the seafloor. Sediment is thickest near the shore, where it comes off the continents in rivers and on wind currents. The oceanic crust is relatively thin and lies above the mantle. The cross section of oceanic crust in the Figure 1.2 shows the layers that grade from sediments at the top to extrusive basalt lava, to the sheeted dikes that feed lava to the surface, to deeper intrusive gabbro, and finally to the mantle. Continental crust is made up of many different types of igneous, metamorphic, and sedimentary rocks. The average composition is granite, which is much less dense than the mafic rocks of the oceanic crust (Figure 1.3). Because it is thick and has relatively low density, continental crust rises higher on the mantle than oceanic crust, which sinks into the mantle to form basins. When filled with water, these basins form the planets oceans. Click image to the left or use the URL below. URL: A cross-section of oceanic crust.", "neg": "To understand minerals, we must first understand matter. Matter is the substance that physical objects are made of. The basic unit of matter is an atom. At the center of an atom is its nucleus. Protons are positively charged particles in the nucleus. Also in the nucleus are neutrons with no electrical charge. Orbiting the nucleus are tiny electrons. Electrons are negatively charged. An atom with the same number of protons and electrons is electrically neutral. If the atom has more or less electrons to protons it is called an ion. An ion will have positive charge if it has more protons than electrons. It will have negative charge if it has more electrons than protons. An atom is the smallest unit of a chemical element. That is, an atom has all the properties of that element. All atoms of the same element have the same number of protons. A molecule is the smallest unit of a chemical compound. A compound is a substance made of two or more elements. The elements in a chemical compound are always present in a certain ratio. Water is probably one of the simplest compounds that you know. A water molecule is made of two hydrogen atoms and one oxygen atom (Figure 3.2). All water molecules have the same ratio: two hydrogen atoms to one oxygen atom. A mineral is a solid material that forms by a natural process. A mineral can be made of an element or a compound. It has a specific chemical composition that is different from other minerals. One minerals physical properties differ from others. These properties include crystal structure, hardness, density and color. Each is made of different elements. Each has different physical properties. For example, silver is a soft, shiny metal. Salt is a white, cube- shaped crystal. Diamond is an extremely hard, translucent crystal. Minerals are made by natural processes. The processes that make minerals happen in or on the Earth. For example, when hot lava cools, mineral crystals form. Minerals also precipitate from water. Some minerals grow when rocks are exposed to high pressures and temperatures. Could something like a mineral be made by a process that was not natural? People make gemstones in a laboratory. Synthetic diamond is a common one. But that stone is not a mineral. It was not formed by a natural process. A mineral is an inorganic substance. It was not made by living organisms. Organic substances contain carbon. Some organic substances are proteins, carbohydrates, and oils. Everything else is inorganic. In a few cases, living organisms make inorganic materials. The calcium carbonate shells made by marine animals are inorganic. All minerals have a definite chemical makeup. A few minerals are made of only one kind of element. Silver is a mineral made only of silver atoms. Diamond and graphite are both made only of the element carbon. Minerals that are not pure elements are made of chemical compounds. For example, the mineral quartz is made of the compound silicon dioxide, or SiO2 . This compound has one atom of the element silicon for every two atoms of the element oxygen. Each mineral has its own unique chemical formula. For example, the mineral hematite has two iron atoms for every three oxygen atoms. The mineral magnetite has three iron atoms for every four oxygen atoms. Many minerals have very complex chemical formulas that include several elements. However, even in more complicated compounds, the elements occur in definite ratios. Minerals must be solid. For example, ice and water have the same chemical composition. Ice is a solid, so it is a mineral. Water is a liquid, so it is not a mineral. Some solids are not crystals. Glass, or the rock obsidian, are solid but not crystals. In a crystal, the atoms are arranged in a pattern. This pattern is regular and it repeats. Figure 3.3 shows how the atoms are arranged in halite (table salt). Halite contains atoms of sodium and chlorine in a pattern. Notice that the pattern goes in all three dimensions. The pattern of atoms in all halite is the same. Think about all of the grains of salt that are", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}397{"query": "Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) is increasing in prevalence among asymptomatic carriers and in cases of paediatric soft-tissue infections alike. CA-MRSA may express virulence factors such as Panton-Valentine leukocidin, which makes soft-tissue and hard-tissue infections due to such organisms challenging to treat. We report a case of osteomyelitis of the proximal tibia in a 10-year-old boy and discuss its management in what is to the authors' knowledge the first case report of Panton-Valentine leukocidin-positive CA-MRSA osteomyelitis in a child in the UK.", "pos": "We describe the clinical characteristics and epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) in children with cystic fibrosis (CF) from the U.S. CF center with the highest MRSA prevalence. Medical records of children with CF were retrospectively reviewed from 1997-2009. MRSA clinical isolates from 2007-2009 were analyzed by polymerase chain reaction and pulsed field gel electrophoresis. The prevalence of MRSA was 1% in 1997 and 49% in 2009. Fifty-five children (26%) had persistent MRSA infection. Sixty-eight percent of MRSA isolates were hospital-associated (HA) MRSA, of which 52% were pulsed-field type USA 100. Ninety-three percent of HA MRSA isolates were clindamycin resistant. Twelve children acquired MRSA before 1 year of age, 83% of whom were hospitalized prior to acquisition of MRSA. Ten of 11 sibling pairs carried indistinguishable MRSA strains. Children with persistent MRSA were hospitalized more often (P=.01), required inhaled medications more frequently (P=.01), and had higher rates of Pseudomonas aeruginosa coinfection (P<.001). MRSA prevalence in children with CF is increasing, and most children are infected with HA MRSA. Exposure to health care facilities and gastrointestinal surgeries may facilitate early acquisition of MRSA. Siblings carry indistinguishable MRSA strains, indicating household transmission of MRSA. Children with persistent MRSA had worse pulmonary morbidity. Coinfection with MRSA and P aeruginosa is likely associated with further increased pulmonary morbidity.", "neg": "Chronic myelogenous leukemia (CML) accounts for 15-20% of adult leukemias but is very rare in children (2%). Fewer than 10% of CML patients are younger than 20 years. CML is a myeloproliferative disorder characterized by the presence of the Philadelphia chromosome or the BCR-ABL fusion oncogene. The objective of this paper is to present the monitoring of imatinib therapy in two children with CML by the BCR-ABL fusion gene expression assessment from peripheral blood with quantitative real-time polymerase chain reaction (PCR) method. The 18 and six months follow-up of the patients included clinical examination, routine laboratory tests, bone marrow aspirate investigation including cytogenetic tests and the major BCR-ABL fusion gene expression measurement with qRT-PCR method from the peripheral blood. Patient No. 1 diagnosed with chronic phase CML showed excellent adherence to daily 400 mg imatinib treatment and achieved complete hematologic (CHR) and cytogenetic response (CCR) by three months and major molecular response (MMR) by 12 months, with lack of side effects due to imatinib. Patient No. 2 experienced severe hematologic toxicity, which necessitated temporary withdrawal of the drug. Transient non-compliance together with imatinib dose reduction has driven to treatment failure. In this case, mutational analysis is warranted. BCR-ABL fusion gene expression level measurement from peripheral blood with qRT-PCR method is an excellent tool in the follow-up of CML patients.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}398{"query": "No. 288 Squadron RAF was a Royal Air Force Squadron formed as an anti-aircraft co-operation unit in World War II.", "pos": "The 19th Light Dragoons was a cavalry regiment of the British Army created in 1781 for service in British India.", "neg": "Desperate Journey is a 1942 American World War II action and aviation film starring Errol Flynn and Ronald Reagan, directed by Raoul Walsh.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}399{"query": "\"We don't necessarily believe that new advertising, which might make consumers feel better about the Coke brand or better about the ads themselves , will actually result in consumers consuming more of the product,\" Morgan Stanley's Bill Pecoriello wrote in a research note the days after the investor meeting . But Coke is optimistic it can regain its old magic, and is banking on a new slogan: \"Welcome to the Coke side of life.\" BREAK THROUGH HIT? With PepsiCo about to surpass Coke as the beverage king on Wall Street--Pepsi's market capitalization has _ in recent years to $97.9 billion, putting it less than a billion dollars behind its rival--the heat is on Coke . It's set to launch a new marketing campaign in March, 2006. And having taken a quick look at Coke's investor presentation on Dec. 7 in New York, my sense is that Coke may be moving in the right direction . Given the continued shift by consumers away from soda--Coke's stronghold --and into alternative beverages like juice, tea, and water, Coke badly needs a breakthrough hit. And given that shift away from soda, some analyists wonder whether even the catchiest new ads will be enough to put the fizz back into Coke. SAME OLD, UPDATED? The new flavors of PowerAde sports drink will probably enable Coke to continue stealing market share from PepsiCo's Gatorade brand. And Coke is getting a little more creative with packaging, including new, aluminum bottles of Coke that will be sold in nightclubs, and an 8.4-ounce \"100 calorie\" version of its flagship Coke that will appeal to women who want fewer calories and will like the fact that the small can will fit in their purse. I doubt whether other new products will be successful, including a new coffee-flavored soda called Coke-Cola Black that I tried. Think carbonated coffee. But I'm not sure if the product, which Coke is pitching as an afternoon pick-me-up for the 35-and-over set, is going to pull people away from their afternoon Frappucino fix. And my opinion is that Vault, an orange-flavored energy drink, will have just as much trouble unseating Mountain Dew among teens as did Coke's last attempt, a product called Surge. If there is one concern I have about the fresh offerings Coke plans to launch this year, it appears that many of them are simply new brands, not new products.", "pos": "When creating a digital advertisement or something to promote a product or service ,music is one of the most important aspects. Whether it is simply a jingle ,musical note or any other use of sound,music can play a huge role in attracting a customer's attention or being noticed by your target audience. Music can work hand-in-hand with what you are advertising. Many times the advertising jingle, or saying, is what the audience remembers. Companies such as McDonald's and Subway have used this method many times with different jingles and little sayings that are easy to remember and fun to sing along with. Usually concepts that are part of a jingle would sound conceited and pompous when said in a normal conversation. When put to music however, and sung in a rhythm,it suddenly sounds attractive. For example, if someone said,\" No one does it better than me\" in a normal statement, this would sound very conceited. Add music and a tune to this statement and it becomes attractive and fun for others to sing along with. While understanding how important music is for your advertising needs, it is also important for you to know the best way to get special music. Having people from many different backgrounds all over the world write something specifically for you is one of the best ways to get songs written just for you. You simply choose which one you believe is best for the project. So instead of hiring a single songwriter to compose your music, you can run a contest for you advertising jingle and songwriters around the world write you a finished jingle in an attempt to win your contest.", "neg": "According to a survey released by the Nielson Company on Thursday, China has become a global tourist attraction after the Beijing Olympics. The survey said the Olympics not only built up China's image but also served as an advertisement for China's tourism. The online survey was conducted on consumers in 16 countries and regions before Games' opening ceremony and after the closing. About 80 percent of the respondents had not been to China before the events and 50 percent of them expressed hopes of visiting China after the Games. According to the survey, 70 percent of the respondents felt Beijing was more modern and scientific than what they had thought. The most interested respondents were from Singapore, India, Mexico, South Africa and the Republic of Korea, as well as China's Hong Kong and Taiwan. Pan Wen, in charge of Chinese tourism research of the Nielson Company, said the World Tourism Organization predicted that China would become the largest tourist attraction in the world with 137 million foreign tourists every year. \"This figure would be realized earlier with the aid of the Beijing Olympics,\" Pan said.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}400{"query": "As the film begins, Daisy Duck is talking to a psychiatrist about an incident that occurred with her boyfriend, Donald. She recalls how they were walking through the park, passing by a skyscraper. On the 99th floor of the skyscraper is a potted flower, which falls and hits Donald on the head, knocking him out. When he comes to, he hears a voice in his head, telling him, \"You are the greatest singer in the world.\" He gets up, and proceeds to croon \"When You Wish upon a Star\" in a Sinatra-like voice. Daisy is stunned, but Donald coldly glances at her as though he does not recognize her. At that moment, a theatrical agent sweeps Donald into his window, causing the flower on his head to fall at Daisy's feet.She takes the flower home, as a way to remember her lost love. She sees Donald everywhere, hawking products and on marquees-- he has become a major celebrity. She almost drives herself insane, but eventually hears that Donald is playing at the Music City Radio Hall. She decides to go see him, but is greatly hindered by a massive crowd. Many months pass, during which Daisy has no success at being able to see Donald.One night, as she is going home, she runs into Donald on the street. She grovels at Donald's feet, but only succeeds in getting a dime thrown at her. She then comes back to the present, where she is talking to the psychiatrist about what happened. The psychiatrist concludes that the hit on the head from the flower pot is what caused Donald to change so radically. He offers to help, but warns her that Donald will no longer be successful if he changes back to normal. Daisy is eager to have him back, though, so the psychiatrist tells her to put the flower in another pot and drop it on Donald's head somehow. She agrees to this plan.That night, as Donald is performing, Daisy slips into the building through the back door. She makes her way past a sleeping security guard, and climbs up into the rafters, where she drops the pot on Donald. It hits him on the head, and he quickly reverts to his regular voice. He is booed off the stage and thrown out of the building, where Daisy is waiting for him. He is thrilled to see her, asking, \"Where have you been?\" They kiss as the film irises out.", "pos": "The officials of a city unveil a new statue, only to find The Tramp sleeping on it. They shoo him away and he wanders the streets, destitute and homeless, and is soon tormented by two newsboys. He happens upon a beautiful Flower Girl (Virginia Cherrill), not realizing at first that she is blind, and buys a flower. Just when she is about to give him his change, a man gets into a nearby luxury car and is driven away, making her think that the Tramp has departed. The Tramp tiptoes away. That evening, the Tramp runs into a drunken Millionaire (Harry Myers) who is attempting suicide on the waterfront. (It is later mentioned that his wife has sent for her bags.) The Tramp eventually convinces The Millionaire he should live. He takes the Tramp back to his mansion and gives him a change of clothes. They go out for a night on the town, where the Tramp inadvertently causes much havoc. Early the next morning, they return to the mansion and encounter the Flower Girl en route to her vending spot. The Tramp asks The Millionaire for some money, which he uses to buy all the girl's flowers and then drives her home in the Millionaire's Rolls-Royce.After he leaves, the Flower Girl tells her Grandmother (Florence Lee) about her wealthy acquaintance. When the Tramp returns to the mansion, the Millionaire has sobered and does not remember him, so has the butler order him out. Later that day, the Millionaire meets the Tramp again while intoxicated, and invites him home for a lavish party. The next morning, having sobered again and planning to leave for a cruise, the Millionaire again has the Tramp tossed out.Returning to the Flower Girl's apartment, the Tramp spies her being attended by a doctor. Deciding to take a job to earn money for her, he becomes a street sweeper. Meanwhile, the Grandmother receives a notice that she and the girl will be evicted if they cannot pay their back rent by the next day, but hides it. The Tramp visits the girl on his lunch break, and sees a newspaper story about a Viennese doctor who has devised an operation that cures blindness. He then finds the eviction notice and reads it aloud at the girl's request. He reassures her that he will pay the rent. But he returns to work late and is fired.As he is walking away, a boxer persuades him to stage a fake fight, promising to split the $50 prize money. Just before the bout, however, the man receives a telegram warning him that the police are after him. He flees, leaving the Tramp a no-nonsense replacement opponent. Despite a valiant effort, the Tramp is knocked out.Some time later, he meets the drunken Millionaire who has just returned from Europe. The Millionaire takes him to the mansion and after he hears the girl's plight, gives the Tramp $1,000. Unbeknownst to the Millionaire and the Tramp, two burglars were hiding in the house when they entered. Upon hearing about the cash, they knock out the millionaire and take the rest of his money. The Tramp telephones for the police, but the robbers flee before they arrive, and the butler assumes he stole the money. The Millionaire cannot remember the Tramp or giving him the $1,000. The Tramp narrowly escapes and gives the money to the girl saying he will be going away for a while. Later, he is arrested in front of the newsboys who taunted him earlier, and jailed.Months later, the Tramp is released. Searching for the girl, he returns to her customary street corner but does not find her. With her sight restored, the girl has opened up a flourishing flower shop with her Grandmother. When a rich customer comes into the shop, the girl briefly wonders if he is her mysterious benefactor. But when he leaves with no acknowledgement, she realizes again she is wrong. While retrieving a flower from the gutter outside the shop, the Tramp is again tormented by the two newsboys. As he turns to leave, he finds himself staring at the girl", "neg": "Early one morning, a taxi pulls up at Tiffany & Co. on Fifth Avenue in New York City, from which elegantly dressed Holly Golightly (Audrey Hepburn) emerges. After looking into the shop's windows, she strolls home. Outside her apartment, she fends off Sid Arbuck (Claude Stroud), her date from the disastrous night before. Later, she is awakened by new neighbor Paul Varjak (George Peppard), ringing her doorbell to get into the building. The pair chat as she dresses to leave for her weekly visit to Sally Tomato (Alan Reed), a mobster incarcerated at Sing Sing prison. Tomato's lawyer, O'Shaughnessy, pays her $100 a week to deliver \"the weather report\". Audrey Hepburn as Holly Golightly As she is leaving for Sing Sing, Holly is introduced to Paul's \"decorator\", wealthy older woman Emily Eustace Failenson (Patricia Neal), whom Paul nicknames \"2E\". That night, Holly goes out onto the fire escape to elude an over-eager date (Mel Blanc). She peeks into Paul's apartment and sees 2E leaving money and kissing Paul goodbye. After 2E leaves, Holly enters Paul's apartment and learns that he is a writer who has not had anything published since a book of vignettes five years before. Holly, in turn, explains that she is trying to save money to support her brother Fred when he gets out of the Army. The pair fall asleep, but are awakened when Holly has a nightmare about Fred. She later buys Paul a typewriter ribbon to apologize and invites him to a party at her apartment. There, Paul meets her Hollywood agent, O. J. Berman (Martin Balsam), who describes Holly's transformation from country girl into Manhattan socialite. He is also introduced to Jose da Silva Pereira (Jose Luis de Vilallonga), a wealthy Brazilian politician, and Rusty Trawler (Stanley Adams), the \"ninth richest man in America under 50.\" In the days that follow, Paul and Holly become closer. One day, 2E enters Paul's apartment, worried that she is being followed. Paul tells her that he will investigate and eventually confronts Doc Golightly (Buddy Ebsen), Holly's estranged husband. Doc explains that Holly's real name is Lula Mae Barnes. They married when she was 13, and he wants to take her back to Texas, as Fred will be returning. After Paul reunites Holly and Doc, she tells Paul the marriage was annulled. At the bus station, she tells Doc she is not going with him. Doc leaves broken-hearted. After drinking at a club, Paul and Holly return to her apartment, where she drunkenly tells him that she plans to marry Trawler for his money. A few days later, Paul learns that one of his short stories will be published. On the way to tell Holly, he sees a newspaper headline stating that Trawler has married someone else. Holly and Paul agree to spend the day together, taking turns doing things that each has never done before. At Tiffany's, Paul has the ring from Doc Golightly's box of Cracker Jack engraved as a present for Holly. After spending the night together, he awakens to find her gone. When 2E arrives, Paul ends their relationship. She calmly accepts, having earlier concluded that he and Holly are in love. Holly schemes to marry Jose for his money, which angers Paul. After Holly receives a telegram notifying her of Fred's death, she trashes her apartment. Months later, Paul has moved out. He is invited to dinner by Holly, who is leaving the next morning for Brazil to continue her relationship with Jose. However, they are arrested in connection with Sally Tomato's drug ring, and Holly spends the night in jail. The next morning, Holly is released on bail and finds Paul waiting, and they take a cab. He has her cat and a letter from Jose explaining he must end their relationship due to her arrest. Holly insists she will go to Brazil anyway, asks the cab to pull over, and releases the", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}401{"query": "Abdali invaded the Mughal Empire seven times from 1748 to 1767. According to Jaswant Lal Mehta, Durrani aroused the Afghans \"religious passions\" to fire and \"sword into the land of infidels India.\" He crossed the Khyber pass in December 1747 with 40,000 troops for his first invasion of India. He occupied Peshawar without any opposition. He first crossed the Indus River in 1748, the year after his ascension- his forces sacked and absorbed Lahore. The following year , the Mughal ruler was induced to cede Sindh and all of the Punjab including the vital trans Indus River to him, in order to save his capital from being attacked by the forces of the Durrani Empire. Having thus gained substantial territories to the east without a fight, Durrani and his forces turned westward to take possession of Herat, which was ruled by Nader Shah's grandson, Shah Rukh. The city fell to the Afghans in 1750, after almost a year of siege and bloody conflict; the Afghan forces then pushed on into present-day Iran, capturing Nishapur and Mashhad in 1751. Durrani then pardoned Shah Rukh and reconstituted Khorasan, but a tributary of the Durrani Empire. This marked the westernmost border of the Afghan Empire as set by the Pul-i-Abrisham, on the Mashhad-Tehran road.", "pos": "Meanwhile, in 1274, the former Dali Kingdom was officially reorganized as the Province of Yunnan, with Sayyid Ajjal Shams al-Din Omar as governor. In May 1275, the governor sent a report to the emperor stating that the embassy had not returned; that the Burmese evidently had no intention of submitting; and that war was the only way forward. But the emperor rejected an outright invasion. Just coming off a disastrous Japanese campaign, the emperor was unwilling to commit the central government troops to what he considered a low priority affair. He was now focused on delivering the final blow against the Song; the emperor ordered the Yunnan provincial army to secure the borderlands in order to block the escape path of the Song refugees. He also sanctioned a limited border war if Pagan contested the takeover. As planned, the Yunnan army proceeded to consolidate the borderlands in 1275-76. Elsewhere, the main Mongol armies had captured most of the Song territory by 1276. By 1277, at least one Burmese vassal state named \"Gold Teeth\" had submitted to the Mongols. Like in 1272, the Burmese government responded by sending an army to reclaim the rebellious state; but unlike in 1272, the Mongols had posted a sizable garrison there. Though it was ultimately under Mongol command, many of the officers and most of the soldiers of the garrison were Turkic-speaking peoples or people from the further west: Turks from Samarkand, Bukhara, Merv and Nishapur, but also captive soldiers from the Persian Khwarazmid empire, the Kipchaks, and even Bulgars from the lower Volga.", "neg": "In 1509, Diogo Lopes de Sequeira was sent to Malacca by the king of Portugal with four ships in order to establish contact with the Sultanate of Malacca. Initially, Sequeira was well received by the Sultan Mahmud Syah . Soon however, the Muslim community convinced Mahmud Syah that the Portuguese should be eliminated. Several men were captured and killed, but the ships escaped. Albuquerque first departed from India for Malacca in April 1511, with 1,200 men and 17 to 18 ships. Albuquerque's objective was to sever Islamic trade and Venetian trade on the same occasion.A first attack by the Portuguese failed on 25 July 1511. Albuquerque's captains spoke against another attempt, but he struck again, succeeding in capturing Malacca in August, despite strong resistance and the presence of artillery on the Malaccan side. In celebration, Tristao da Cunha was sent to Pope Leo X in Rome with rich presents including the elephant that the pope named Hanno.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}402{"query": "Chronicles of Avonlea is a collection of short stories by L. M. Montgomery, related to the Anne of Green Gables series.", "pos": "We Few is the fourth novel in the science fiction Empire of Man series by David Weber and John Ringo.", "neg": "The Lump of Coal is a Christmas short story written by Lemony Snicket and illustrated by Brett Helquist.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}403{"query": "The water that comes out of our faucets is safe because it has gone through a series of treatment and purification processes to remove contaminants. Those of us who are fortunate enough to always be able to get clean water from a tap in our home may have trouble imagining life in a country that cannot afford the technology to treat and purify water. Many people in the world have no choice but to drink from the same polluted river where sewage is dumped. One- fifth of all people in the world, more than 1.1 billion people, do not have access to safe water for drinking, personal cleanliness, and domestic use. Unsafe drinking water carries many pathogens, or disease-causing biological agents such as infectious bacteria and parasites. Toxic chemicals and radiological hazards in water can also cause diseases. Waterborne disease caused by unsafe drinking water is the leading cause of death for children under the age of five in many nations and a cause of death and illness for many adults. About 88% of all diseases are caused by drinking unsafe water (Figure 1.1). Throughout the world, more than 14,000 people die every day from waterborne diseases, such as cholera, and many of the worlds hospital beds are occupied by patients suffering from a waterborne disease. Guinea worm is a serious problem in parts of Africa that is being eradicated. Learn what is being done to decrease the number of people suffering from this parasite at the video below. Click image to the left or use the URL below. URL:", "pos": "Humans use six times as much water today as they did 100 years ago. People living in developed countries use a far greater proportion of the worlds water than people in less developed countries. What do people use all of that water for? Besides drinking and washing, people need water for agriculture, industry, household uses, and recreation (Figure Water use can be consumptive or non-consumptive, depending on whether the water is lost to the ecosystem. Non-consumptive water use includes water that can be recycled and reused. For example, the water that goes down the drain and enters the sewer system is purified and then redistributed for reuse. By recycling water, the overall water consumption is reduced. Consumptive water use takes the water out of the ecosystem. Can you name some examples of consumptive water use? Some of the worlds farmers still farm without irrigation by choosing crops that match the amount of rain that falls in their area. But some years are wet and others are dry. For farmers to avoid years in which they produce little or no food, many of the worlds crops are produced using irrigation. Water used for home, industrial, and agricultural purposes in different regions. Globally more than two-thirds of water is for agriculture. Three popular irrigation methods are: Overhead sprinklers. Trench irrigation: canals carry water from a water source to the fields. Flood irrigation: fields are flooded with water. All of these methods waste water. Between 15% and 36% percent of the water never reaches the crops because it evaporates or leaves the fields as runoff. Water that runs off a field often takes valuable soil with it. A much more efficient way to water crops is drip irrigation (Figure 1.2). With drip irrigation, pipes and tubes deliver small amounts of water directly to the soil at the roots of each plant or tree. The water is not sprayed into the air or over the ground, so nearly all of it goes directly into the soil and plant roots. Why do farmers use wasteful irrigation methods when water-efficient methods are available? Many farmers and farming corporations have not switched to more efficient irrigation methods for two reasons: 1. Drip irrigation and other more efficient irrigation methods are more expensive than sprinklers, trenches, and flooding. 2. In the United States and some other countries, the government pays for much of the cost of the water that is used for agriculture. Because farmers do not pay the full cost of their water use, they do not have any financial incentive to use less water. What ideas can you come up with to encourage farmers to use more efficient irrigation systems? Aquaculture is a different type of agriculture. Aquaculture is farming to raise fish, shellfish, algae, or aquatic plants (Figure 1.3). As the supplies of fish from lakes, rivers, and the oceans dwindle, people are getting more fish from aquaculture. Raising fish increases our food resources and is especially valuable where protein sources are limited. Farmed fish are becoming increasingly common in grocery stores all over the world. Workers at a fish farm harvest fish they will sell to stores. Growing fish in a large scale requires that the fish stocks are healthy and protected from predators. The species raised must be hearty, inexpensive to feed, and able to reproduce in captivity. Wastes must be flushed out to keep animals healthy. Raising shellfish at farms can also be successful. For some species, aquaculture is very successful and environmental harm is minimal. But for other species, aqua- culture can cause problems. Natural landscapes, such as mangroves, which are rich ecosystems and also protect coastlines from storm damage, may be lost to fish farms (Figure 1.4). For fish farmers, keeping costs down may be a problem since coastal land may be expensive and labor costs may be high. Large predatory fish at the 4th or 5th trophic level must eat a lot, so feeding large numbers of these fish is expensive and environmentally costly. Farmed fish are genetically different from wild stocks, and if they escape into the wild they may cause problems for native fish. Because the organisms live so close together", "neg": "Water pollution contributes to water shortages by making some water sources unavailable for use. In underdeveloped countries, raw sewage is dumped into the same water that people drink and bathe in. Even in developed countries, water pollution affects human and environmental health. Water pollution includes any contaminant that gets into lakes, streams, and oceans. The most widespread source of water contamination in developing countries is raw sewage. In developed countries, the three main sources of water pollution are described below. Wastewater from cities and towns contains many different contaminants from many different homes, businesses, and industries (Figure 1.1). Contaminants come from: Sewage disposal (some sewage is inadequately treated or untreated). Storm drains. Septic tanks (sewage from homes). Boats that dump sewage. Yard runoff (fertilizer and herbicide waste). Large numbers of sewage spills into San Francisco Bay are forcing cities, water agencies and the public to take a closer look at wastewater and its impacts on the health of the bay. QUEST investigates the causes of the spills and whats being done to prevent them. Click image to the left or use the URL below. URL: Factories and hospitals spew pollutants into the air and waterways (Figure 1.2). Some of the most hazardous industrial pollutants include: Radioactive substances from nuclear power plants and medical and scientific sources. Heavy metals, organic toxins, oils, and solids in industrial waste. Chemicals, such as sulfur, from burning fossil fuels. Oil and other petroleum products from supertanker spills and offshore drilling accidents. Heated water from industrial processes, such as power stations. Runoff from crops, livestock, and poultry farming carries contaminants such as fertilizers, pesticides, and animal waste into nearby waterways (Figure 1.3). Soil and silt also run off farms. Animal wastes may carry harmful diseases, particularly in the developing world. The high density of animals in a factory farm means that runoff from the area is full of pollutants. Fertilizers that run off of lawns and farm fields are extremely harmful to the environment. Nutrients, such as nitrates, in the fertilizer promote algae growth in the water they flow into. With the excess nutrients, lakes, rivers, and bays become clogged with algae and aquatic plants. Eventually these organisms die and decompose. Decomposition uses up all the dissolved oxygen in the water. Without oxygen, large numbers of plants, fish, and bottom-dwelling animals die.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}404{"query": "Antisense therapy with both chemistries of phosphorodiamidate morpholino oligomers (PMOs) and 2'-O-methyl phosphorothioate has demonstrated the capability to induce dystrophin expression in Duchenne muscular dystrophy (DMD) patients in phase II-III clinical trials with benefit in muscle functions. However, potential of the therapy for DMD at different stages of the disease progression is not understood. In this study, we examined the effect of peptide-conjugated PMO (PPMO)-mediated exon skipping on disease progression of utrophin-dystrophin-deficient mice (dko) of four age groups (21-29, 30-39, 40-49 and 50+ days), representing diseases from early stage to advanced stage with severe kyphosis. Biweekly intravenous (i.v.) administration of the PPMO restored the dystrophin expression in nearly 100% skeletal muscle fibers in all age groups. This was associated with the restoration of dystrophin-associated proteins including functional glycosylated dystroglycan and neuronal nitric synthase. However, therapeutic outcomes clearly depended on severity of the disease at the time the treatment started. The PPMO treatment alleviated the disease pathology and significantly prolonged the life span of the mice receiving treatment at younger age with mild phenotype. However, restoration of high levels of dystrophin expression failed to prevent disease progression to the mice receiving treatment when disease was already at advanced stage. The results could be critical for design of clinical trials with antisense therapy to DMD.", "pos": "Rosiglitazone, a synthetic peroxisome proliferator-activated receptor- (PPAR) agonist, prevents cell death after cerebral ischemia in animal models, but the underlying mechanism has not been clarified. In this study, we examined how rosiglitazone protects neurons against ischemia. Mice treated with rosiglitazone were subjected to 60 minutes of focal ischemia followed by reperfusion. Rosiglitazone reduced infarct volume after ischemia and reperfusion. We show that this neuroprotective effect was reversed with a PPAR antagonist. Western blot analysis showed a significant increase in expression of phosphorylated stress-activated protein kinases (c-Jun N-terminal kinase (JNK) and p38) in ischemic brain tissue. Rosiglitazone blocked this increase. Furthermore, we observed that rosiglitazone increased expression of the dual-specificity phosphatase 8 (DUSP8) protein and messenger RNA in ischemic brain tissue. Dual-specificity phosphatase 8 is a mitogen-activated protein kinase phosphatase that can dephosphorylate JNK and p38. Another key finding of the present study was that knockdown of DUSP8 in primary cultured cortical neurons that were subjected to oxygen-glucose deprivation diminished rosiglitazone's effect on downregulation of JNK phosphorylation. Thus, rosiglitazone's neuroprotective effect after ischemia is mediated by blocking JNK phosphorylation induced by ischemia via DUSP8 upregulation.", "neg": "L-DOPA-induced dyskinesia is a common side effect developed after chronic treatment with 3,4-dihydroxyphenyl-l-alanine (l-DOPA) in Parkinson's disease. The biological mechanisms behind this side effect are not fully comprehended although involvement of dopaminergic, serotonergic, and glutamatergic systems has been suggested. The present study utilizes in vivo amperometry to investigate the impact from unilateral 6-hydroxydopamine lesions and l-DOPA (4 mg/kg, including benserazide 15 mg/kg) -induced dyskinetic behavior on striatal basal extracellular glutamate concentration and potassium-evoked glutamate release in urethane-anesthetized rats. Recordings were performed before and after local L-DOPA application in the striatum. In addition, effects from the 5-HT(1A) receptor agonist (2R)-(+)-8-hydroxy-2-(di-n-propylamino)tetralin hydrobromide (8-OHDPAT; 1 mg/kg) was assessed on glutamate release and on dyskinetic behavior. The results revealed a bilateral 30% reduction of basal extracellular glutamate concentration and attenuated potassium-evoked glutamate release after a unilateral dopamine-depletion in L-DOPA naive animals. In dyskinetic subjects, basal glutamate concentration was comparable to normal controls, although potassium-evoked glutamate release was reduced to similar levels as in drug naive dopamine-lesioned animals. Furthermore, acute striatal L-DOPA administration attenuated glutamate release in all groups, except in the dopamine-lesioned striatum of dyskinetic animals. Co-administration of 8-OHDPAT and L-DOPA decreased dyskinesia in dopamine-lesioned animals, but did not affect potassium-evoked glutamate release, which was seen in normal animals. These findings indicate altered glutamate transmission upon dopamine-depletion and dyskinesia.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}405{"query": "TDRS-11 was launched at 01:48 UTC on 31 January 2013, at the beginning of a 40-minute launch window.", "pos": "TabletSat-Aurora was launched from Dombarovsky (air base) site 13, Russia, on 19 June 2014 by a Dnepr-1 rocket.", "neg": "CBSN is an internet television news channel operated by the CBS News and CBS Interactive divisions of CBS Corporation which launched on November 6, 2014.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}406{"query": "Damien Ryan (born 20 September 1979) is an Australian professional basketball player.", "pos": "Sven Kaldre (born 31 October 1991) is a professional basketball player who plays as a shooting guard.", "neg": "Mira Bjedov, married Nikolic, (born 7 September 1955 in Mokro Polje) is a former basketball player who competed for Yugoslavia in the 1980 Summer Olympics.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}407{"query": "The officials of a city unveil a new statue, only to find The Tramp sleeping on it. They shoo him away and he wanders the streets, destitute and homeless, and is soon tormented by two newsboys. He happens upon a beautiful Flower Girl (Virginia Cherrill), not realizing at first that she is blind, and buys a flower. Just when she is about to give him his change, a man gets into a nearby luxury car and is driven away, making her think that the Tramp has departed. The Tramp tiptoes away. That evening, the Tramp runs into a drunken Millionaire (Harry Myers) who is attempting suicide on the waterfront. (It is later mentioned that his wife has sent for her bags.) The Tramp eventually convinces The Millionaire he should live. He takes the Tramp back to his mansion and gives him a change of clothes. They go out for a night on the town, where the Tramp inadvertently causes much havoc. Early the next morning, they return to the mansion and encounter the Flower Girl en route to her vending spot. The Tramp asks The Millionaire for some money, which he uses to buy all the girl's flowers and then drives her home in the Millionaire's Rolls-Royce.After he leaves, the Flower Girl tells her Grandmother (Florence Lee) about her wealthy acquaintance. When the Tramp returns to the mansion, the Millionaire has sobered and does not remember him, so has the butler order him out. Later that day, the Millionaire meets the Tramp again while intoxicated, and invites him home for a lavish party. The next morning, having sobered again and planning to leave for a cruise, the Millionaire again has the Tramp tossed out.Returning to the Flower Girl's apartment, the Tramp spies her being attended by a doctor. Deciding to take a job to earn money for her, he becomes a street sweeper. Meanwhile, the Grandmother receives a notice that she and the girl will be evicted if they cannot pay their back rent by the next day, but hides it. The Tramp visits the girl on his lunch break, and sees a newspaper story about a Viennese doctor who has devised an operation that cures blindness. He then finds the eviction notice and reads it aloud at the girl's request. He reassures her that he will pay the rent. But he returns to work late and is fired.As he is walking away, a boxer persuades him to stage a fake fight, promising to split the $50 prize money. Just before the bout, however, the man receives a telegram warning him that the police are after him. He flees, leaving the Tramp a no-nonsense replacement opponent. Despite a valiant effort, the Tramp is knocked out.Some time later, he meets the drunken Millionaire who has just returned from Europe. The Millionaire takes him to the mansion and after he hears the girl's plight, gives the Tramp $1,000. Unbeknownst to the Millionaire and the Tramp, two burglars were hiding in the house when they entered. Upon hearing about the cash, they knock out the millionaire and take the rest of his money. The Tramp telephones for the police, but the robbers flee before they arrive, and the butler assumes he stole the money. The Millionaire cannot remember the Tramp or giving him the $1,000. The Tramp narrowly escapes and gives the money to the girl saying he will be going away for a while. Later, he is arrested in front of the newsboys who taunted him earlier, and jailed.Months later, the Tramp is released. Searching for the girl, he returns to her customary street corner but does not find her. With her sight restored, the girl has opened up a flourishing flower shop with her Grandmother. When a rich customer comes into the shop, the girl briefly wonders if he is her mysterious benefactor. But when he leaves with no acknowledgement, she realizes again she is wrong. While retrieving a flower from the gutter outside the shop, the Tramp is again tormented by the two newsboys. As he turns to leave, he finds himself staring at the girl", "pos": "Ian Lafferty (Josh Zuckerman) is an 18-year-old recent high school graduate. He searches for a girl online making it seem as if he is attractive and strong, although he's sweet and unassuming. He soon meets \"Ms. Tasty\" (Katrina Bowden) and agrees to meet her in person. She lives in Knoxville, Tennessee, while he lives in Chicago, Illinois. With his best friends Lance Nesbitt (Clark Duke) and Felicia Alpine (Amanda Crew), he goes to Knoxville in a 1969 Pontiac GTO Judge borrowed without permission from Ian's arrogant homophobic older brother Rex (James Marsden). On the way to Knoxville, they come across a hitchhiker (David Koechner), as the radiator in the Judge overheats. They attempt urinating in the radiator, which only works briefly as they try to leave the hitchhiker in the dust. The hitchhiker, frustrated at Ian's lack of concern for his well being, leaves, but not before urinating on the car window. As Ian and Felicia wander to find help, Lance is waiting with the car as Ezekiel (Seth Green) happens to pass by in his horse-drawn buggy. Ezekiel and his Amish buddies repair the car while they join a Rumspringa party where Fall Out Boy are playing a concert, and at which Lance meets an attractive Amish girl, Mary (Alice Greczyn). The three promise to come again on the way back to do some work in return for fixing the car. They go to jail due to Ian throwing a tire iron into a state trooper car, due to his increasing frustration after trying to put a possum he hit out of its misery, and are released after Mary pays the bail. Upon arriving at Knoxville, they find a hotel that sports a wide variety of role playing rooms. Rex, who has discovered the Judge gone missing, arrives angrily and insists that they go back and that Ian cannot visit Ms. Tasty. After Ian pretends to be gay, Rex allows him to see Ms. Tasty, hoping this encounter will change Ian's mind. Ian finally meets Ms. Tasty. However, when he tells her about Felicia, her seduction for Ian to take off his clothes becomes a threat as her psychotic boyfriend Bobby Jo (Dave Sheridan) puts a gun to Ian's head. It becomes apparent that they work at a chop shop and attempt to steal the Judge. Lance and Mary arrive after having sex, as well as a redneck named Rick (Michael Cudlitz) whose girlfriend Brandy (Andrea Anders) slept with Lance earlier. Felicia, however, is hiding in the car when Bobby Jo tries to steal it. Soon, a green car that has been continuously drag-racing with the Judge throughout the movie arrives. Ian manages to save Felicia, who then is able to run off and report to the police. Ms. Tasty tries to escape, but is stopped by the green car, whose drivers turn out to be Andy and Randy (Charlie McDermott and Mark L. Young), two dim-witted self-declared \"womanizers\" from Ian's school, who Ms. Tasty tried to manipulate into giving her the car. Bobby Jo is treated after being shot by Ian in self-defense. Felicia tells the police about the chop shop location and the couple is arrested. Upon finding out that if Mary leaves the Amish community, she will be shunned, Lance refuses to come back home and stays behind to marry Mary, while Ian and Felicia realize their love for each other. Ian and Felicia drive to a tree where Ian throws his shoes up into the tree. A few weeks later Ian is Felicia's date to her cousin's wedding. At Thanksgiving dinner, Rex tells his family that he's gay. On New Year's Eve Ian and Felicia finally have sex, in Ian's basement under a blanket on the sofa. In the final frame of the film, a picture is shown of Lance and Mary getting married, accompanied by Ian. Lance is shown sporting a beard exactly like Ezekiel's. During the credits, a short scene is shown of Ezekiel and Fall Out Boy arguing over the fact that the", "neg": "Early one morning, a taxi pulls up at Tiffany & Co. on Fifth Avenue in New York City, from which elegantly dressed Holly Golightly (Audrey Hepburn) emerges. After looking into the shop's windows, she strolls home. Outside her apartment, she fends off Sid Arbuck (Claude Stroud), her date from the disastrous night before. Later, she is awakened by new neighbor Paul Varjak (George Peppard), ringing her doorbell to get into the building. The pair chat as she dresses to leave for her weekly visit to Sally Tomato (Alan Reed), a mobster incarcerated at Sing Sing prison. Tomato's lawyer, O'Shaughnessy, pays her $100 a week to deliver \"the weather report\". Audrey Hepburn as Holly Golightly As she is leaving for Sing Sing, Holly is introduced to Paul's \"decorator\", wealthy older woman Emily Eustace Failenson (Patricia Neal), whom Paul nicknames \"2E\". That night, Holly goes out onto the fire escape to elude an over-eager date (Mel Blanc). She peeks into Paul's apartment and sees 2E leaving money and kissing Paul goodbye. After 2E leaves, Holly enters Paul's apartment and learns that he is a writer who has not had anything published since a book of vignettes five years before. Holly, in turn, explains that she is trying to save money to support her brother Fred when he gets out of the Army. The pair fall asleep, but are awakened when Holly has a nightmare about Fred. She later buys Paul a typewriter ribbon to apologize and invites him to a party at her apartment. There, Paul meets her Hollywood agent, O. J. Berman (Martin Balsam), who describes Holly's transformation from country girl into Manhattan socialite. He is also introduced to Jose da Silva Pereira (Jose Luis de Vilallonga), a wealthy Brazilian politician, and Rusty Trawler (Stanley Adams), the \"ninth richest man in America under 50.\" In the days that follow, Paul and Holly become closer. One day, 2E enters Paul's apartment, worried that she is being followed. Paul tells her that he will investigate and eventually confronts Doc Golightly (Buddy Ebsen), Holly's estranged husband. Doc explains that Holly's real name is Lula Mae Barnes. They married when she was 13, and he wants to take her back to Texas, as Fred will be returning. After Paul reunites Holly and Doc, she tells Paul the marriage was annulled. At the bus station, she tells Doc she is not going with him. Doc leaves broken-hearted. After drinking at a club, Paul and Holly return to her apartment, where she drunkenly tells him that she plans to marry Trawler for his money. A few days later, Paul learns that one of his short stories will be published. On the way to tell Holly, he sees a newspaper headline stating that Trawler has married someone else. Holly and Paul agree to spend the day together, taking turns doing things that each has never done before. At Tiffany's, Paul has the ring from Doc Golightly's box of Cracker Jack engraved as a present for Holly. After spending the night together, he awakens to find her gone. When 2E arrives, Paul ends their relationship. She calmly accepts, having earlier concluded that he and Holly are in love. Holly schemes to marry Jose for his money, which angers Paul. After Holly receives a telegram notifying her of Fred's death, she trashes her apartment. Months later, Paul has moved out. He is invited to dinner by Holly, who is leaving the next morning for Brazil to continue her relationship with Jose. However, they are arrested in connection with Sally Tomato's drug ring, and Holly spends the night in jail. The next morning, Holly is released on bail and finds Paul waiting, and they take a cab. He has her cat and a letter from Jose explaining he must end their relationship due to her arrest. Holly insists she will go to Brazil anyway, asks the cab to pull over, and releases the", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}408{"query": "The Villa Empain is a private house in the Art Deco style designed and built between 1930 and 1934 by Swiss architect Michel Polak for Baron Louis Empain, son of Belgian industrialist Baron Edouard Empain, located in Brussels, Belgium.", "pos": "The Witte Huis (Dutch pronunciation: (t ys)) or White House is a building and National Heritage Site in Rotterdam, Netherlands, built in 1898 in the Art Nouveau style.", "neg": "He retired to the Villa Bianca (now named ''Villa Grock''), a 50-room house he had had built in the 1920s in Imperia, Italy, where he died in 1959.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}409{"query": "However, due to the U.S. Army's recent reorganization, only 4th Squadron remains in active service. 4th Squadron, 10th Cavalry takes its history and lineage from D Troop, 10th Cavalry. In 2000, D Troop, 10th U.S. Cavalry, was reactivated and assigned as the brigade reconnaissance troop for 3rd Brigade Combat Team, 3rd Infantry Division at Fort Benning, Georgia. D Troop, 10th Cavalry was deployed with 3/3 ID to Iraq in 2003, and was deactivated upon redeployment in 2004. It was reactivated in October 2007 at Fort Carson, Colorado, replacing the 2nd Squadron, 9th Cavalry regiment, as the 4th Squadron, 10th Cavalry Regiment with A, B, C, and HQ Troops as the reconnaissance squadron for 3rd Combat Brigade Team of the 4th Infantry Division. The 4th Squadron deployed to Iraq with the BCT from December 2007 to February 2009, and again in March 2010. The Squadron deployed to Jordan in 2015 in support of Operation Spartan Shield. In February 2016, Delta Tank Company from 1st Battalion, 8th Infantry Regiment moved to 4th Squadron, 10th Cavalry Regiment to be assigned as Dakota Troop. As of February 2016, 4th Squadron, 10th Cavalry Regiment is the only current active unit of the 10th Cavalry Regiment.", "pos": "The 10th Cavalry returned from the Philippines in late 1902 and settled down in different posts in the south western United States. Patrols and garrison life was the routine for the regiment. Under war plans, the 10th was designated for service in the Pacific and support in the Philippines from 1915 through 1942 but never rotated there. The 9th Cavalry Regiment became \"Park Rangers\" in 1905 for Yosemite National Park and other state and federal lands. The Troopers' Campaign Hat, sporting the \"Montana Pinch\" used to help shed the tropical downpours. That \"Montana Pinch\" gave the hat the distinctive look we recognize today as the \"Smokey Bear Hat\".", "neg": "At the start of World War II, the 24th Infantry was stationed at Fort Benning as school troops for the Infantry School. They participated in the Carolina Maneuvers of October - December 1941. During World War II, the 24th Infantry fought in the South Pacific Theatre as a separate regiment. Deploying on 4 April 1942 from the San Francisco Port of Embarkation, the regiment arrived in the New Hebrides Islands on 4 May 1942. The 24th moved to Guadalcanal on 28 August 1943, and was assigned to the XIV Corps. 1st Battalion deployed to Bougainville, attached to the 37th Infantry Division, from March to May 1944 for perimeter defense duty. The regiment departed Guadalcanal on 8 December 1944, and landed on Saipan and Tinian on 19 December 1944 for Garrison Duty that included mopping up the remaining Japanese forces that had yet to surrender. The regiment was assigned to the Pacific Ocean Area Command on 15 March 1945, and then to the Central Pacific Base Command on 15 May 1945, and to the Western pacific Base Command on 22 June 1945. The regiment departed Saipan and Tinian on 9 July 1945, and arrived on the Kerama Islands off Okinawa on 29 July 1945. At the end of the war, the 24th took the surrender of forces on the island of Aka-shima, the first formal surrender of a Japanese Imperial Army garrison. The regiment remained on Okinawa through 1946.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}410{"query": "Despite that deep brain stimulation (DBS) of the globus pallidus internus (GPi) is emerging as the favored intervention for patients with medically intractable dystonia, the pathophysiological mechanisms of dystonia are largely unclear. In eight patients with primary dystonia who were treated with bilateral chronic pallidal stimulation, we correlated symptom-related electromyogram (EMG) activity of the most affected muscles with the local field potentials (LFPs) recorded from the globus pallidus electrodes. In 5 dystonic patients with mobile involuntary movements, rhythmic EMG bursts in the contralateral muscles were coherent with the oscillations in the pallidal LFPs at the burst frequency. In contrast, no significant coherence was seen between EMG and LFPs either for the sustained activity separated out from the compound EMGs in those 5 cases, or in the EMGs in 3 other cases without mobile involuntary movements and rhythmic EMG bursts. In comparison with the resting condition, in both active and passive movements, significant modulation in the GPi LFPs was seen in the range of 8-16 Hz. The finding of significant coherence between GPi oscillations and rhythmic EMG bursts but not sustained tonic EMG activity suggests that the synchronized pallidal activity may be directly related to the rhythmic involuntary movements. In contrast, the sustained hypertonic muscle activity may be represented by less synchronized activity in the pallidum. Thus, the pallidum may play different roles in generating different components of the dystonic symptom complex.", "pos": "Deep brain stimulation (DBS) is the technique of neurostimulation of deep brain structures for the treatment of conditions such as essential tremor, dystonia, Parkinson's disease and chronic pain syndromes. The procedure uses implanted deep brain stimulation electrodes connected to extension leads and an implantable pulse generator (IPG). Hardware failure related to the DBS procedure is not infrequent, and includes electrode migration and disconnection. We describe a patient who received bilateral globus pallidus internus DBS for dystonia with initially good clinical response, but the device eventually failed. Radiographs showed multiple twisting of the extension leads with disconnection from the brain electrodes and a diagnosis of Twiddler's syndrome was made. Twiddler's syndrome was first described in patients with cardiac pacemakers. Patients with mental disability, elderly and obese patients are at increased risk. Twiddler's syndrome should be suspected whenever there is a failure of the DBS device to relieve symptoms previously responsive to stimulation. Surgical correction is usually required.", "neg": "There is no consensus about mechanisms underlying restless legs syndrome (RLS), also known as Willis-Ekbom disease (WED). Cortical excitability may be abnormal in RLS. Transcranial magnetic stimulation (TMS) can provide insight about cortical excitability. We reviewed studies about measures of excitability to TMS in RLS. Original studies published between January 1999 and January 2015 were searched in PubMed, Scopus, and Web of Science databases. Inclusion criteria were as follows: original studies involving primary RLS in patients from both sexes and ages between 18 and 85 years; TMS protocols clearly described; and they were written in English, in peer-reviewed journals. Fifteen manuscripts were identified. TMS protocols were heterogeneous across studies. Resting motor threshold, active motor threshold, and amplitudes of motor-evoked potentials were typically reported to be normal in RLS. A reduction in short-interval intracortical inhibition (SICI) was the most consistent finding, whereas conflicting results were described in regard to short-interval intracortical facilitation and the contralateral silent period. Decreased SICI can be reversed by treatment with dopaminergic agonists. Plasticity in the motor cortex and sensorimotor integration may be disrupted. TMS may become a useful biomarker of responsiveness to drug treatment in RLS. The field can benefit from increases in homogeneity and sizes of samples, as well as from decrease in methodological variability across studies.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}411{"query": "Like all organisms, bacteria need energy, and they can acquire this energy through a number of different ways. Photosynthetic bacteria use the energy of the sun to make their own food. In the presence of sunlight, carbon dioxide and water are turned into glucose and oxygen. The glucose is then turned into usable energy. Glucose is like the \"food\" for the bacteria. An example of photosynthetic bacteria is cyanobacteria, as seen in the opening image. These bacteria are sometimes called blue-green algae, although they are not algae, due to their numerous chlorophyll molecules. Bacteria known as decomposers break down wastes and dead organisms into smaller molecules. These bacteria use the organic substrates they break down to get their energy, carbon, and nutrients they need for survival. Bacteria can also be chemotrophs. Chemosynthetic bacteria, or chemotrophs, obtain energy by breaking down chemical compounds in their environment. An example of one of these chemicals broken down by bacteria is nitrogen-containing ammonia. These bacteria are important because they help cycle nitrogen through the environ- ment for other living things to use. Nitrogen cannot be made by living organisms, so it must be continually recycled. Organisms need nitrogen to make organic compounds, such as DNA. Some bacteria depend on other organisms for survival. For example, some bacteria live in the roots of legumes, such as pea plants ( Figure 1.1). The bacteria turn nitrogen-containing molecules into nitrogen that the plant can use. Meanwhile, the root provides nutrients to the bacteria. In this relationship, both the bacteria and the plant benefit, so it is known as a mutualism. Other mutualistic bacteria include gut microbes. These are bacteria that live in the intestines of animals. They are usually beneficial bacteria, needed by the host organism. These microbes obviously dont kill their host, as that would kill the bacteria as well. Other bacteria are parasitic and can cause illness. In parasitism, the bacteria benefit, and the other organism is harmed. Harmful bacteria will be discussed in another concept.", "pos": "Organic molecules must also carry out the chemical work of cells; that is, their metabolism. Chemical reactions in a living organism allow that organism to live in its environment, grow, and reproduce. Metabolism gets energy from other sources and creates structures needed in cells. The chemical reactions occur in a sequence of steps known as metabolic pathways. The metabolic pathways are very similar between unicellular bacteria that have been around for billions of years and the most complex life forms on Earth today. This means that they evolved very early in Earths history. Living cells need organic molecules, known as nucleic acids, to store genetic information and pass it to the next generation. Deoxyribonucleic acid (DNA) is the nucleic acid that carries information for nearly all living cells today and did for most of Earths history. Ribonucleic acid (RNA) delivers genetic instructions to the location in a cell where protein is synthesized. Many scientists think that RNA was the first replicator. Since RNA catalyzes protein synthesis, most scientists think that RNA came before proteins. RNA can also encode genetic instructions and carry it to daughter cells, such as DNA. The idea that RNA is the most primitive organic molecule is called the RNA world hypothesis, referring to the possibility that the RNA is more ancient than DNA. RNA can pass along genetic instructions as DNA can, and some RNA can carry out chemical reactions like proteins can. Click image to the left or use the URL below. URL: Pieces of many scenarios can be put together to come up with a plausible suggestion for how life began. Click image to the left or use the URL below. URL:", "neg": "Five characteristics are used to define life. All living things share these characteristics. All living things: 1. 2. 3. 4. 5. are made of one or more cells. need energy to stay alive. respond to stimuli in their environment. grow and reproduce. maintain a stable internal environment. Cells are the basic building blocks of life. They are like tiny factories where virtually all life processes take place. Some living things, like the bacteria in Figure 2.1, consist of just one cell. They are called single-celled organisms. You can see other single-celled organisms in Figure 2.2. Some living things are composed of a few to many trillions of cells. They are called multicellular organisms. Your body is composed of trillions of cells. Regardless of the type of organism, all living cells share certain basic structures. For example, all cells are enclosed by a membrane. The cell membrane separates the cell from its environment. It also controls what enters or leaves the cell. Everything you do takes energy. Energy is the ability to change or move matter. Whether its reading these words or running a sprint, it requires energy. In fact, it takes energy just to stay alive. Where do you get energy? You probably know the answer. You get energy from food. Figure {{ref|MS-LS-SE-02-03-Food|below}] shows some healthy foods that can provide you with energy. Just like you, other living things need a source of energy. But they may use a different source. Organisms may be grouped on the basis of the source of energy they use. In which group do you belong? Producers such as the tree in Figure 2.1 use sunlight for energy to produce their own food. The process is called photosynthesis, and the food is sugar. Plants and other organisms use this food for energy. Consumers such as the raccoon in Figure 2.1 eat plantsor other consumers that eat plantsas a source of energy. Some consumers such as the mushroom in Figure 2.1 get their energy from dead organic matter. For example, they might consume dead leaves on a forest floor. When a living thing responds to its environment, it is responding to a stimulus. A stimulus (stimuli, plural) is something in the environment that causes a reaction in an organism. The reaction a stimulus produces is called a response. Imagine how you would respond to the following stimuli: Youre about to cross a street when the walk light turns red. You hear a smoke alarm go off in the kitchen. You step on an upturned tack with a bare foot. You smell the aroma of your favorite food. You taste something really sour. It doesnt take much imagination to realize that responding appropriately to such stimuli might help keep you safe. It might even help you survive. Like you, all other living things sense and respond to stimuli in their environment. In general, their responses help them survive or reproduce. Watch this amazing time-lapse video to see how a plant responds to the stimuli of light and gravity as it grows. Why do you think it is important for a plant to respond appropriately to these stimuli for proper growth? MEDIA Click image to the left or use the URL below. URL: Like plants, all living things have the capacity for growth. The ducklings in Figure 2.4 have a lot of growing to do to catch up in size to their mother. Multicellular organisms like ducks grow by increasing the size and number of their cells. Single-celled organisms just grow in size. As the ducklings grow, they will develop and mature into adults. By adulthood, they will be able to reproduce. Reproduction is the production of offspring. The ability to reproduce is another characteristic of living things. Many organisms reproduce sexually. In sexual reproduction, parents of different sexes mate to produce offspring. The offspring have some combination of the traits of the two parents. Ducks are examples of sexually reproducing organisms. Other organisms reproduce asexually. In asexual reproduction, a single parent can produce offspring alone. For example, a bacterial cell reproduces by dividing into two daughter cells.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}412{"query": "Cystic fibrosis (CF) is the most common inherited disorder in Caucasian populations, with over 1400 mutations identified in the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) gene. Mutations in the CFTR gene may be also causative for CBAVD (Congenital Bilateral Absence of the Vas Deferens). The type and distribution of mutations varies widely between different countries and/or ethnic groups, and is relatively unknown in Iran. We therefore performed a comprehensive analysis of the CFTR gene in Iranian CF patients. 69 Iranian CF patients, and 1 CBAVD patient, were analysed for mutations in the complete coding region, and its exon/intron junctions, of their CFTR genes, using different methods, such as ARMS (amplification refractory mutation system)-PCR, SSCP (single stranded conformation polymorphism) analysis, restriction enzyme digestion analysis, direct sequencing, and MLPA (Multiplex Ligation-mediated Probe Amplification). CFTR mutation analysis revealed the identification of 37 mutations in 69 Iranian CF patients. Overall, 81.9% (113/138) CFTR genes derived from Iranian CF patients could be characterized for a disease-causing mutation. The CBAVD patient was found to be homozygous for the p.W1145R mutation. The most common mutations were p.F508del (DeltaF508) (18.1%), c.2183_2184delAAinsG (2183AA>G) (6.5%), p.S466X (5.8%), p.N1303K (4.3%), c.2789+5G>A (4.3%), p.G542X (3.6%), c.3120+1G>A (3.6%), p.R334W (2.9%) and c.3130delA (2.9%). These 9 types of mutant CFTR genes totaled for 52% of all CFTR genes derived from the 69 Iranian CF patients. Eight mutations, c.406-8T>C, p.A566D, c.2576delA, c.2752-1_2756delGGTGGCinsTTG, p.T1036I, p.W1145R, c.3850-24G>A, c.1342-?_1524+?del, were found for the first time in this study. We identified 37 CFTR mutations in 69 well characterized Iranian CF patients, obtaining a CFTR mutation detection rate of 81.9%, the highest detection rate obtained in the Iranian population so far. These findings will assist in genetic counseling, prenatal diagnosis and future screening of CF in Iran.", "pos": "The objective was to determine the composition of the Cystic Fibrosis (CF) Population attending specialist UK CF centres in terms of age, gender, age at diagnosis, genotype and ethnicity. With the planned introduction of the national CF screening programme in the UK, cystic fibrosis transmembrane regulator (CFTR) mutations were compared between different ethnic groups enabling a UK-specific frequency of mutations to be defined. Data were analysed from the patient biographies held in the UK CF Database (see www.cystic-fibrosis.org.uk). The currently registered population of 5,274 CF patients is 96.3% Caucasian with a male preponderance that significantly increases with age. The majority of the 196 non-Caucasian CF patients are from the Indian Subcontinent (ISC), of which one in 84 UK CF patients are of Pakistani origin. The commonest CFTR mutation, deltaF508, is found in 74.1% of all CF chromosomes. In the Caucasian CF population, 57.5% are deltaF508 homozygotes but the UK ISC CF population with only 24.7%, has significantly fewer deltaF508 homozygotes patients (95% confidence interval (CI) 0.2-0.4). The distribution of Caucasian patients with deltaF508/deltaF508, deltaF508/Other and Other/Other does not fit the expected distribution with a Hardy-Weinberg model unless those patients without a detected mutation are excluded (P<0.001). The UK CF Database has shown the UK CF population to have distinct characteristics separate from the North American and European CF Registries. The ISC group contains many mutations not recognised by current genetic analysis, and one in four ISC patients have no CFTR mutations identified. The CFTR analysis proposed for the screening programme would detect 96% of patients registered in the database, but is unlikely to achieve the desired >80% detection rates in the ethnic minority groups. Screen-positive, non-Caucasian infants without an identifiable CFTR mutation should be referred for a sweat test and genetic counselling when serum trypsinogen concentrations remain elevated after birth.", "neg": "We describe the clinical characteristics and epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) in children with cystic fibrosis (CF) from the U.S. CF center with the highest MRSA prevalence. Medical records of children with CF were retrospectively reviewed from 1997-2009. MRSA clinical isolates from 2007-2009 were analyzed by polymerase chain reaction and pulsed field gel electrophoresis. The prevalence of MRSA was 1% in 1997 and 49% in 2009. Fifty-five children (26%) had persistent MRSA infection. Sixty-eight percent of MRSA isolates were hospital-associated (HA) MRSA, of which 52% were pulsed-field type USA 100. Ninety-three percent of HA MRSA isolates were clindamycin resistant. Twelve children acquired MRSA before 1 year of age, 83% of whom were hospitalized prior to acquisition of MRSA. Ten of 11 sibling pairs carried indistinguishable MRSA strains. Children with persistent MRSA were hospitalized more often (P=.01), required inhaled medications more frequently (P=.01), and had higher rates of Pseudomonas aeruginosa coinfection (P<.001). MRSA prevalence in children with CF is increasing, and most children are infected with HA MRSA. Exposure to health care facilities and gastrointestinal surgeries may facilitate early acquisition of MRSA. Siblings carry indistinguishable MRSA strains, indicating household transmission of MRSA. Children with persistent MRSA had worse pulmonary morbidity. Coinfection with MRSA and P aeruginosa is likely associated with further increased pulmonary morbidity.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}413{"query": "The film opens with a man, Alderson (Julian Richings), waking up in a cube-shaped room with glowing, computer circuit-like walls and six doors, one at the center of each wall, ceiling and floor. After recovering from his confusion, he opens two of the doors and looks into them to find rooms that differ to the one he is in only by color. He then opens and goes through a third door. He looks around and then takes a step, but is suddenly cut into large cubes. He falls apart and the rack of crosshatched wires which diced him moves into view. It folds up and retracts.Later, in another room, several people find each other: Quentin (Maurice Dean Wint), Worth (David Hewlett), Holloway (Nicky Guadagni), Rennes (Wayne Robson), and Leaven (Nicole de Boer). None of them know where they are, how they got there, or why they are there. Quentin, however, knows that there are traps, as he had looked into a room and nearly got his head cut off. The five decide to stay together and look for the way out. Rennes takes the lead. He exemplifies how to test for traps by tossing a boot into the rooms while holding onto the laces, to trigger potential traps, figuring that the trapped room contains motion detectors. Holloway speculates on several possible creators of the Cube, being aliens or the government his main ptions. Rennes remarks that staying still will not solve anything, and says that they should move in a straight line until they get to the end. The others agree, and they begin moving through the rooms.While moving, they discover a series of different numbers on the hatchways between each of the rooms. At one point, Rennes throws the boot in and does not find anything, but detects that the room has dry air, and deduces that it most likely employs an electrochemical sensor, which detects hydrogen sulphide emitted from the skin. Quentin realizes that Rennes is an escape artist who has escaped more than seven major prisons. Soon after, Rennes jumps into a room tested with a boot, and is sprayed in the face with acid. The others pull him back, but he dies as the acid corrodes his face and the inside of his head. The group decides that the room must have contained an electrochemical sensor which Rennes missed, and realize that they must find a better way of testing the rooms.Quentin asks everyone about their occupations. He says he is a police officer, Holloway says she is a doctor, and Worth says he works \"in an office building, doing office building stuff.\" Leaven claims simply to \"hang out\" with her friends. Quentin believes that nothing is a coincidence, that each of them has a purpose in the cube. After Holloway talks about her rings and broaches, Quentin asks why Leaven has her glasses, while Holloway has had her jewellery taken away. Leaven reveals herself to excel at mathematics, and after looking at the numbers on a crawlspace, theorizes that when one of those numbers is prime, the room is booby-trapped.Leaven's purpose becomes attempting to \"crack the Cube's code\", and they progress through the cubes. When they find themselves in a room with trapped rooms all around and below, Quentin checks the door in the ceiling, through which falls a seventh person: Kazan (Andrew Miller). He appears to be mentally handicapped. At least two of the others see him as a burden, but Holloway decides to bring him along.The group starts speculating about their surroundings, which causes a conflict between Quentin and Holloway. Quentin dismisses Holloway's ideas as conspiracy theories, and Holloway thinks that Quentin is naive. Soon after this, Quentin enters a room without prime numbers and narrowly avoids death from a trap consisting of rotating razor wires. Leaven's theory that non-prime-numbered rooms are safe is shown to be incorrect. Quentin begins suspecting that Worth is a spy, and is increasingly irritated by Kazan's mental state. The group rests, while Leaven attempts to decipher the numbers", "pos": "The film tells the story of a psychiatrist, Dr. Cross (Vincent Price), who is treating a young woman, Janet Stewart (Anabel Shaw), who is in a coma-state, brought on when she heard loud arguing, went to her window and saw a man strike his wife with a candlestick and kill her. It also stars Lynn Bari as Dr. Cross's nurse/lover, Elaine Jordan. As Stewart comes out of her shock, she recognizes Dr. Cross as the killer. He then takes her to his sanitarium and at Elaine's urging, gives Janet an overdose of insulin under the pretense of administering insulin shock therapy. He can't bring himself to murder her in cold blood, though, and asks Elaine to get the medicine to save her. Elaine refuses, they argue, and he strangles her. A colleague of Dr. Cross, Dr. Harvey, saves Janet's life and Dr. Cross is taken into custody by a lawyer from the District Attorney's office.", "neg": "The movie begins in the year 1967 with a pregnant woman being admitted to a hospital, bleeding from the neck. Paramedics think she was attacked by some type of animal. Doctors perform an emergency C-Section, and her baby (a boy) is born alive just as she dies.Thirty years later a young man named Dennis (Kenny Johnson) is riding in a car with an attractive redhead named Racquel (Traci Lords) heading to an underground nightclub (located, oddly, in a slaughterhouse) somewhere in Los Angeles. After addressing the doorman in Russian, Racquel brings the young man into the club. The man is confused and trying to understand the rules of the club. Some of the regulars indifferently push him aside. Saying he needs a drink, the sprinkler suddenly system activates, raining blood down on everyone inside. It is then that he (and the audience) realizes that everyone in the club is a vampire.Dennis desperately tries to get away and winds up at the feet of a menacing figure in a black-leather trenchcoat. The vampires look on this figure with awe, mumbling the words: \"it's the Daywalker!\" This is our first look at Blade (Wesley Snipes), the vampire killer.Blade pulls out a shotgun and opens fire on the vampires, who instantly burn to ashes when killed. When the gun is knocked out of his hands by Racquel, Blade uses a set of silver stakes to kill Racquel and more vampires, including the disk jockey. Soon all the vamps are either dead or have fled except for one; a heavyset vamp named Quinn (Donal Logue), whom Blade has apparently run into before. Blade pins Quinn to the wall, and then sets him on fire before confronting the last member in the club (the human man from the beginning). Finding no vampire bite marks on Dennis, Blade lets him live and makes his escape as the police arrive.Quinn is extinguished and taken to the local hospital. A morgue technician examines his blood and shows the results to Dr. Karen Jenson (N'Bushe Wright), who finds a number of irregularities, including abnormally developed jaw muscles. As they are discussing the test results, Quinn springs back to life and bites both doctors. Before he can finish Dr. Jenson, Blade shows up and saves her, cutting off one of Quinn's arms.Blade brings Karen to his hideout and asks for help from his mentor, an elderly man named named Whistler (Kris Kristofferson). Whistler injects Dr. Jenson with a solution of garlic essence and silver nitrate and remarks that she has a 50/50 chance of recovering.Meanwhile, a group of vampires are discussing Blade's latest attack on their members. Apparently this club (and to an extent, Quinn) is the property of a vampire named Deacon Frost (Stephen Dorff). Frost wants the vampires to outright rule the humans and use them as a food source while the others (particularly an older vampire named Dragonetti) prefer to maintain a peaceful co-existance. Dragonetti (Udo Kier) in particular does not like Frost because Frost is not a \"pure-blood\" (ie: was not born a vampire, merely became one through the bite of another). Frost is also arrogant and his & the actions of his followers draw unnecessary attention to the vampire underworld.The next morning, Jenson awakens and sees Whistler injecting Blade with some type of serum. She tries to run away but Whistler confronts her and tells her that he and Blade are hunting vampires. Karen of course is skeptical, but Whistler goes on to talk about what they use to hunt- explaining that vampires are severely allergic to silver & garlic while also being vulnerable to sunlight (ultraviolet rays in particular). Whistler fuels up Blade's car and gives him a new UV flashlight to use when hunting that night. Whistler also gives Karen a type of \"vampire mace\" (garlic & silver nitrate in a liquid form).Blade drops Karen off at her apartment and she tries to pack up and get out of town. A police officer, identifying himself as Officer Krieger (Kevin Patrick Walls), arrives and questions her about the events", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}414{"query": "The Van Gogh Museum's Wheatfield with Crows was painted in July 1890, in the last weeks of van Gogh's life.", "pos": "The Duel After the Masquerade is a painting by the French artist Jean-Leon Gerome, currently part of The Walters Art Museum collection.", "neg": "Juliana Sveinsdottir (31 July 1889 -- 1966) was one of Iceland's first female painters and textile artists.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}415{"query": "September 1939. Mrs. Kay Miniver (Greer Garson) and her family live a comfortable life at a house called 'Starlings' in Belham, a fictional village outside London, England. The house has a large garden, with a private landing stage on the River Thames at which is moored a motorboat belonging to her devoted husband Clem (Walter Pidgeon), a successful architect. They have three children: the youngsters Toby and Judy (Christopher Severn and Clare Sandars) and an older son Vin (Richard Ney) at university. They have live-in staff: Gladys the housemaid (Brenda Forbes) and Ada the cook (Marie De Becker).As World War II looms, Vin comes down from university and meets Carol Beldon (Teresa Wright), granddaughter of Lady Beldon (Dame May Whitty) from nearby Beldon Hall. Despite initial disagreements (mainly contrasting Vin's idealistic attitude to class differences with Carol's practical altruism) they fall in love. Vin proposes to Carol in front of his family at home after his younger brother prods him to give a less romantic but more honest proposal.Several months later, as the war comes closer to home with the bombing of Great Brittan, Vin feels he must \"do his bit\" and enlists in the Royal Air Force, qualifying as a fighter pilot. He is posted to a base near to his parents' home and is able to signal his safe return from operations to his parents by cutting his engines briefly as he flies over the house. Together with other boat owners, Clem volunteers to take his motorboat to assist in the May-June 1940 Dunkirk evacuation.Early one morning, Kay unable to sleep as Clem is still away, wanders down to the landing stage. She is startled to discover a wounded German pilot (Helmut Dantine) hiding in her garden and he holds her at gunpoint. Demanding food and a coat, the pilot maniacally asserts that the Third Reich will mercilessly overcome its enemies. She feeds him, calmly disarms him and then calls the police. Soon after, Clem returns home, exhausted, from Dunkirk.Lady Beldon visits Kay to try and convince her to talk Vin out of marrying Carol on account of her granddaughter's comparative youth. Lady Beldon is unsuccessful and admits defeat when Kay reminds her that she, too, was young when she married her late husband. Lady Beldon concedes defeat and realises that she would be foolish to try and stop the marriage. Vin and Carol are married; Carol has now also become Mrs Miniver, and they return from their honeymoon in Scotland. A key theme is that she knows he is likely to be killed in action, but the short love will fill her life. Later, Kay and her family take refuge in their Anderson shelter in the garden during an air raid, and attempt to keep their minds off the frightening bombing by reading Alice's Adventures in Wonderland, which Clem refers to as a \"lovely story\" as they barely survive a bomb destroys parts of the house. They take the damage with nonchalance.At the annual village flower show, Lady Beldon silently disregards the judges' decision that her rose is the winner, instead announcing the entry of the local stationmaster, Mr. Ballard (Henry Travers), named the \"Mrs. Miniver\" rose, as the winner, with her own rose taking second prize. As air raid sirens sound and the villagers take refuge in the cellars of Beldon Hall, Kay and Carol drive Vin to join his squadron. On their journey home they witness fighter planes in a 'dogfight'. For safety, Kay stops the car and they see the German plane crash. Kay realises Carol has been wounded by shots from the plane and takes her back to 'Starlings'. She dies a few minutes after they reach home. Kay is devastated. When Vin returns from battle, he already knows the terrible news. Unexpectedly he is the survivor, and she the one who gives her life for England.The villagers assemble at the badly damaged church where their vicar (Henry Wilcoxon) affirms their determination in a powerful sermon:\"We in this quiet corner of England have suffered the loss of friends very dear to us, some", "pos": "New England, the late 1950s. Todd Anderson (Ethan Hawke), a lonely and painfully shy teenager, who is under pressure by his stern parents because he must live up to his older brother's reputation to attend Yale and become a lawyer, arrives for the new semester at the Welton Academy for boys -- Todd's brother also attended Welton and was a popular and well-regarded student there. This semester begins during an orientation gathering with a speech given by the stern Headmaster Nolan (Norman Lloyd), who states the academy's four pillars: Tradition, Honor, Discipline, and Excellence. Todd meets Neil Perry (Robert Sean Leonard) an ambitious student whom becomes his dorm roommate.Later in his dorm, Neil is ordered by his grumpy and domineering father (Kurtwood Smith) to drop his involvement with the school annual in order to maintain good grades so the boy may become a doctor much as he has done. Neil is under pressure from his stern father's will. Also, Mr. Perry tells Neil that Mrs. Perry also wants him to become a doctor, which further worries the boy. A little later, Todd tells Neil that he is in a similar situation with his parents involving his older brother who also attended Welton a few years ago, graduated, and attended Yale Law School and became a lawyer and his parents want the exact same thing for him. But Todd does not have the courage to tell his parents that he instead wants to be a writer, not a lawyer.During the first day of classes Todd and Neil experience the various teaching methods which include speeches by the trig teacher, as well as the Latin teacher, and the math teacher who states that \"all 20 questions at the end of the first chapter are due tomorrow\". In stark contrast to these orthodox teaching methods, the guys see a different side of the school when they attend English class taught by the newly arrived (and liberal-minded) Mr. Keating (Robin Williams), whom they met briefly during the orientation -- Keating tells his class he was also a student at Welton (\"Helton\" as the students secretly refer to the institution) himself many years ago. Keating enters his class whistling the 1812 Overture, and he first takes the boys out in the hallway to the school's displays cases containing artifacts of the school's sports achievements. He tells them that they all have the potential to become powerful individuals, and they are responsible for what their futures will hold. These two actions show his difference from the other teachers because no other teacher would commit the actions he does. Also, he tells the boys they may call him \"Oh Captain, my Captain\", if they dare. These examples of Mr. Keating's teachings show the boys how to think for themselves. Mr. Keating then tells the boys \"Carpe Diem\", which is Latin for \"seize the day\".In addition to Todd and Neil, a small group of other students whom include the lovesick Knox Overstreet (Josh Charles), the flip Charlie Dalton (Gale Hansen), the pragmatic Richard Cameron (Dylan Kussman), liberal Steven Meeks (Allelon Ruggiero) and the moderate Gerard Pitts (James Waterston), also react to the first day's lesson with comments from \"that was weird\" to \"neat\". Cameron asks if anything Keating told them will be on a future test and the boys respond with mild scorn.The next day Keating starts the class with a traditional teaching approach by having Neil read out loud the introduction to their poetry textbook, which describes how to rate the quality of poetry according to mathematical plotting. Keating finds such mathematical criticism ridiculous and instructs his pupils to rip out the essay which is one of three ways that he demonstrates freedom of expression and non-conformity. When some students hesitate, he tells them \"this is not the Bible. This is a battle, a war. You will have to learn to think for yourselves.\" He later has the students stand on his desk as a reminder to look at the world in a different way.A few days later, Knox Overstreet is asked to attend a dinner party at the Danburry", "neg": "At the Kibbutz Stein in Israel in 1956, school teacher Rachel (Clarice van Houten) is reunited with Ronnie (Halina Reijn), a friend from The Hague during World War II. After Ronnie leaves, Rachel reflects on her adventures during the final days of the war.In 1944, Rachel hides from the Nazis in a farm in the Dutch countryside. In exchange for hiding her, they expect her to learn Bible verses. One day, a crippled Allied bomber drops its payload on the farmhouse, killing everyone except Rachel. Rob (Michiel Heisman), a young man from a neighboring farm, hides her in the family's greenhouse. That night, Van Gein (Peter Blok), a police officer, arrives to tell them that the Nazis know that Rachel is in the area and will hunt her down. He agrees to help Rachel and Rob escape to the Allied controlled southern part of Holland. Rachel visits her father's lawyer, Smaal (Dolf de Vries). He gives her enough money and jewels to live on for a year but warns her not to trust people so easily. Van Gein leads Rachel and Rob to a dock where other Jews wait to leave. Rachel is reunited with her parents and brother, who is recovering from an emergency appendectomy. Van Gein does not accompany the Jews on the boat trip. That evening, the boat is ambushed by a Nazi patrol boat. The Nazis immediately open fire; only Rachel survives the massacre. Before drifting down the river, she sees the Nazis loot the corpses.Rachel is found by Resistance fighters who smuggle her into The Hague by disguising her as a typhoid victim and placing her in a coffin that if properly \"sealed\" has sizable air holes. She is taken to a soup kitchen run by another member of the Resistance, Gerben Kuipers (Derek de Lint) and given the new name of Ellis de Vries. Eventually she is made a part of the Resistance's plans to smuggle in British guns and rations. The smugglers are led by Hans Akkermans (Thom Hoffman), an expert marksman. He and Ellis are to pose as husband and wife so the Nazis will not search their luggage on the train; the luggage is actually full of weaponry. But when the Nazi soldiers on the train clearly do intend to search all baggage, a new plan is needed. Ellis takes the bags and enters a private compartment occupied by SD Colonel Muntze (Sebastian Koch). The Nazis don't search Muntze's compartment. Ellis and Muntze are clearly attracted to each other and she accepts an offer to visit him at his office. Hans is clearly jealous.A truck carrying the British guns crashes in front of the soup kitchen. Kuiper's son, Tim (Ronald Armbrust) was driving and is arrested by the Gestapo. While the others go into hiding, Ellis arranges a meeting with Muntze hoping that she can persuade him to release Tim. Knowing he is an avid stamp collector, she takes some rare Dutch stamps to him. He invites her to a Nazi party. There she sees SS commandant Gunter Franken (Waldemar Kobus) and recognizes him as the Nazi who led the ambush against the refugee boat. Although she is sickened at his sight, she manages to sing at the party later. She and Muntze return to his suite to make love. He intuits that she is Jewish from her dyed blond hair but has fallen in love with her. She accepts a job in his office and begins work the following day. There she meets Ronnie, who is Franken's secretary/sex partner. Franken gives them a report indicating that Tim has confessed everything and is to be executed, however, Muntze refuses to sign the execution order.Ellis sees Smaal at Nazi headquarters and learns that he and Muntze have negotiated a cease fire -- if the Resistance ceases its attacks against the Nazis, the Nazis will cease its violent reprisals against Dutch civilians. However, when a hidden microphone placed by Ellis in Franken's office reveals that Franken and Van Gein have been working together to kill and rob Jews trying to escape into Allied territory, a controversy amongst the Resistance fighters ensues. Van Gein is heard", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}416{"query": "Noar Linhas Aereas Flight 4896 was a passenger flight which crashed in Boa Viagem, Recife, Brazil, on 13 July 2011.", "pos": "TAROM Flight 3107 was a charter flight operated by a Boeing 737-300 that, on 30 December 2007, during the takeoff procedure, hit a service car carrying out repair work on lighting equipment on the runway at Henri Coanda International Airport in Otopeni, Romania.", "neg": "Pierre Curie died in a street accident in Paris on 19 April 1906.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}417{"query": "U.S. Bottled Water Sales Are Booming Again Despite Opposition Despite organized anti-bottled-water campaigns across the country and a noisy debate about bottled water's environmental impact, Americans are buying more bottled water than ever. Why do so many people seem to think they should have any input on what other American's choose to buy or do? If they want to buy bottled water, let them. If they want to eat fast food, let them. If they want to smoke pot, let them. -- Barackalypse People just get tired of paying for others' bad behavior. If many people eat excessive fast food, you pay higher insurance premiums. If many people frequently buy bottled water, your trash bills go up and landfills fill up quickly.www.zxxk.com It's about personal responsibility, which really should be a cornerstone of libertarianism. -- Bdbr So? This is the price you pay to live in a free society. You want to control the life of another just so you can save a few bucks? What would you say when someone do the same to you? -- Norman619 Defend selfish pricks all you like; I'm just glad there are still people who still believe personal responsibility is a good and decent thing. We make your life cheaper and less bothersome. -- Yoyo What a waste of money! It's fine when you're on the road and you need a cold drink, but people who buy cases of bottled water for home are completely crazy. -- Agmlauncher I wish we all can find a way to improve things and benefit from this. The environment needs a lot of help but businesses will always work on what people would need and demand. Is this part of the balance? Hope we can find better ways. -- Skipweis", "pos": "When did you last visit a shopping mall? In many places, the answer would be \"last weekend.\" Some people go even more often. Why? For one thing, malls offer goods and services that people need all in one place: food, clothing, things for their houses, entertainment, even medical services. So, are malls one of the highlights of modern civilization? Environmental activists would say No! They would go even further and say that consumer behavior is causing a huge environmental disaster. cause consumers of ignorance of the side effect of their shopping--urban sprawl . Social scientists agree that patterns of development have changed the landscape a great deal in the last half century. Before 1950, most people lived in towns or cities and either walked to work or took public transportation. Only very wealthy people had automobiles. Farmers lived in rural areas or isolated villages and came into town only when they needed things they couldn't produce themselves. If you gazed at the landscape you would see towns surrounded by countryside. Then a massive change occurred. Automobiles became affordable and people were quick to adopt them. Now ambitious workers could live in the suburbs, the areas just outside cities, which started to grow rapidly. As long as there was lots of cheap land in the suburbs, no one paid much attention to the usage of that land. Malls, fast food restaurants, cinemas, and car dealerships spread out in large, flat buildings. These one-storey buildings and their parking lot took up a great deal space. Well- meaning farmers thought they were better off selling their land than growing crops. In ignorance, no one realized that once the land was built up in urban sprawl, the good farming land would be ruined forever. There was no way to preserve it. Only in recent years have people come to mourn the old way of life as they have developed insight into the problems. Now people realize that urban sprawl has come with serious environmental problems. The negative aspects of sprawl include air and water pollution, loss of agricultural land, traffic jams, and the death of businesses in the old town centers. Many scholars think the time has come to analyze the problems better so we can develop appropriate policies to control further sprawl. Some think the best way to do is to educate citizens about their priceless environment.", "neg": "Humans use six times as much water today as they did 100 years ago. People living in developed countries use a far greater proportion of the worlds water than people in less developed countries. What do people use all of that water for? Besides drinking and washing, people need water for agriculture, industry, household uses, and recreation (Figure Water use can be consumptive or non-consumptive, depending on whether the water is lost to the ecosystem. Non-consumptive water use includes water that can be recycled and reused. For example, the water that goes down the drain and enters the sewer system is purified and then redistributed for reuse. By recycling water, the overall water consumption is reduced. Consumptive water use takes the water out of the ecosystem. Can you name some examples of consumptive water use? Some of the worlds farmers still farm without irrigation by choosing crops that match the amount of rain that falls in their area. But some years are wet and others are dry. For farmers to avoid years in which they produce little or no food, many of the worlds crops are produced using irrigation. Water used for home, industrial, and agricultural purposes in different regions. Globally more than two-thirds of water is for agriculture. Three popular irrigation methods are: Overhead sprinklers. Trench irrigation: canals carry water from a water source to the fields. Flood irrigation: fields are flooded with water. All of these methods waste water. Between 15% and 36% percent of the water never reaches the crops because it evaporates or leaves the fields as runoff. Water that runs off a field often takes valuable soil with it. A much more efficient way to water crops is drip irrigation (Figure 1.2). With drip irrigation, pipes and tubes deliver small amounts of water directly to the soil at the roots of each plant or tree. The water is not sprayed into the air or over the ground, so nearly all of it goes directly into the soil and plant roots. Why do farmers use wasteful irrigation methods when water-efficient methods are available? Many farmers and farming corporations have not switched to more efficient irrigation methods for two reasons: 1. Drip irrigation and other more efficient irrigation methods are more expensive than sprinklers, trenches, and flooding. 2. In the United States and some other countries, the government pays for much of the cost of the water that is used for agriculture. Because farmers do not pay the full cost of their water use, they do not have any financial incentive to use less water. What ideas can you come up with to encourage farmers to use more efficient irrigation systems? Aquaculture is a different type of agriculture. Aquaculture is farming to raise fish, shellfish, algae, or aquatic plants (Figure 1.3). As the supplies of fish from lakes, rivers, and the oceans dwindle, people are getting more fish from aquaculture. Raising fish increases our food resources and is especially valuable where protein sources are limited. Farmed fish are becoming increasingly common in grocery stores all over the world. Workers at a fish farm harvest fish they will sell to stores. Growing fish in a large scale requires that the fish stocks are healthy and protected from predators. The species raised must be hearty, inexpensive to feed, and able to reproduce in captivity. Wastes must be flushed out to keep animals healthy. Raising shellfish at farms can also be successful. For some species, aquaculture is very successful and environmental harm is minimal. But for other species, aqua- culture can cause problems. Natural landscapes, such as mangroves, which are rich ecosystems and also protect coastlines from storm damage, may be lost to fish farms (Figure 1.4). For fish farmers, keeping costs down may be a problem since coastal land may be expensive and labor costs may be high. Large predatory fish at the 4th or 5th trophic level must eat a lot, so feeding large numbers of these fish is expensive and environmentally costly. Farmed fish are genetically different from wild stocks, and if they escape into the wild they may cause problems for native fish. Because the organisms live so close together", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}418{"query": "We report the development of OikoBase ([Link] a tiling array-based genome browser resource for Oikopleura dioica, a metazoan belonging to the urochordates, the closest extant group to vertebrates. OikoBase facilitates retrieval and mining of a variety of useful genomics information. First, it includes a genome browser which interrogates 1260 genomic sequence scaffolds and features gene, transcript and CDS annotation tracks. Second, we annotated gene models with gene ontology (GO) terms and InterPro domains which are directly accessible in the browser with links to their entries in the GO ([Link] and InterPro ([Link] databases, and we provide transcript and peptide links for sequence downloads. Third, we introduce the transcriptomics of a comprehensive set of developmental stages of O. dioica at high resolution and provide downloadable gene expression data for all developmental stages. Fourth, we incorporate a BLAST tool to identify homologs of genes and proteins. Finally, we include a tutorial that describes how to use OikoBase as well as a link to detailed methods, explaining the data generation and analysis pipeline. OikoBase will provide a valuable resource for research in chordate development, genome evolution and plasticity and the molecular ecology of this important marine planktonic organism.", "pos": "We present RADAR--a rigorously annotated database of A-to-I RNA editing (available at [Link] The identification of A-to-I RNA editing sites has been dramatically accelerated in the past few years by high-throughput RNA sequencing studies. RADAR includes a comprehensive collection of A-to-I RNA editing sites identified in humans (Homo sapiens), mice (Mus musculus) and flies (Drosophila melanogaster), together with extensive manually curated annotations for each editing site. RADAR also includes an expandable listing of tissue-specific editing levels for each editing site, which will facilitate the assignment of biological functions to specific editing sites.", "neg": "Although peak finding in next-generation sequencing (NGS) datasets has been addressed extensively, there is no consensus on how to analyze and process biological replicates. Furthermore, most peak finders do not focus on accurate determination of enrichment site widths and are not widely applicable to different types of datasets. We developed JAMM (Joint Analysis of NGS replicates via Mixture Model clustering): a peak finder that can integrate information from biological replicates, determine enrichment site widths accurately and resolve neighboring narrow peaks. JAMM is a universal peak finder that is applicable to different types of datasets. We show that JAMM is among the best performing peak finders in terms of site detection accuracy and in terms of accurate determination of enrichment sites widths. In addition, JAMM's replicate integration improves peak spatial resolution, sorting and peak finding accuracy. JAMM is available for free and can run on Linux machines through the command line: [Link]", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}419{"query": "Peroxiredoxin 2 (Prx2) is an antioxidant enzyme that uses cysteine residues to decompose peroxides. Prx2 is the third most abundant protein in erythrocytes, and competes effectively with catalase and glutathione peroxidase to scavenge low levels of hydrogen peroxide, including that derived from hemoglobin autoxidation. Low thioredoxin reductase activity in the erythrocyte is able to keep up with this basal oxidation and maintain the Prx2 in its reduced form, but exposure to exogenous hydrogen peroxide causes accumulation of the disulfide-linked dimer. The high cellular concentration means that although turnover is slow, erythrocyte Prx2 can act as a noncatalytic scavenger of hydrogen peroxide and a sink for hydrogen peroxide before turnover becomes limiting. The consequences of Prx2 oxidation for the erythrocyte are not well characterized, but mice deficient in this protein develop severe hemolytic anemia associated with Heinz body formation. Prx2, also known as calpromotin, regulates ion transport by associating with the membrane and activating the Gardos channel. How Prx2 redox transformations are linked to membrane association and channel activation is yet to be established. In this review, we discuss the functional properties of Prx2 and its role as a major component of the erythrocyte antioxidant system.", "pos": "Many studies have reported that the generation of reactive oxygen species (ROS) increases during the differentiation of muscle-derived C2C12 cells. Peroxiredoxin-2 (Prx-2) is an abundant mammalian enzyme that protects against oxidative stress. However, the role of Prx-2 in muscle differentiation has not been investigated. In this study, we demonstrated that Prx-2 expression increases during muscle differentiation and regeneration in response to exogenous H(2)O(2). This increase occurs only in myoblast cell lines because no increase in Prx-2 expression was observed in the NIH3T3, MEF, Chang, or HEK293 cell lines. The antioxidants, N-acetyl L-cysteine (NAC) and 4,5-dihydroxy-1,3-benzenedisulfonic acid (Tiron), both suppressed myogenesis and Prx-2 expression. Moreover, Prx-2 was upregulated at the transcriptional level by NF-B during the differentiation of muscle-derived C2C12 cells. We also found that inhibition of phosphatidylinositol 3-kinase (PI3K) blocks NF-B activation and suppresses Prx-2 expression. Interestingly, Prx-2 knockdown increased the expression levels of other antioxidant enzymes, including all of the other Prx family member, thioredoxin-1 (Trx-1) and catalase, but also enhanced the accumulation of endogenous ROS during muscle differentiation. In this study, we demonstrated for the first time that Prx-2 is unregulated during the muscle differentiation and regeneration. Prx-2 is upregulated via the PI3K/NF-B pathway and attenuates oxidative stress during muscle differentiation and regeneration.", "neg": "Heme is critical for a variety of cellular processes, but excess intracellular heme may result in oxidative stress and membrane injury. Feline leukemia virus subgroup C receptor (FLVCR1), a member of the SLC49 family of four paralogous genes, is a cell surface heme exporter, essential for erythropoiesis and systemic iron homeostasis. Disruption of FLVCR1 function blocks development of erythroid progenitors, likely due to heme toxicity. Mutations of SLC49A1 encoding FLVCR1 are noted in patients with a rare neurodegenerative disorder: posterior column ataxia with retinitis pigmentosa. FLVCR2 is highly homologous to FLVCR1 and may function as a cellular heme importer. Mutations of SLC49A2 encoding FLVCR2 are observed in Fowler syndrome, a rare proliferative vascular disorder of the brain. The functions of the remaining members of the SLC49 family, MFSD7 and DIRC2 (encoded by the SLC49A3 and SLC49A4 genes), are unknown, although the latter is implicated in hereditary renal carcinomas. SLC48A1 (heme responsive gene-1, HRG-1), the sole member of the SLC48 family, is associated with the endosome and appears to transport heme from the endosome into the cytosol.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}420{"query": "A huge cloud of dust rose and an overpass disappeared. This was the scene in Zhuzhou,Hunan Province on May 17.Nine people were killed and 16 injured. Things were similar last year in the Sichuan earthquake. Thousands of people were buried in the ruins and lost their lives. What if we could have warned them? People are always _ to find a way of preventing buildings' collapse. Better materials and technology help,but they are not a solution. Just like humans,a building has its own life cycle from \"birth\" to \"death\".If we know when a building is going to collapse,we can repair it in advance or get out of it before it falls. Now,scientists at the University of Illinois have developed a material that turns red before it breaks. The invention could be used in things like climbing ropes or bridge supports. The research was led by Nancy Sottos,a professor at the university's Beckman Institute,and Douglas Davis,a graduate research assistant. The secret behind the colorchanging material is a type of molecule .A molecule is a group of atoms held together by chemical bonds. Imagine you and your friends standing in a circle,holding hands. Each person stands for one atom,your hands represent the bonds,and the entire circle represents a molecule. If one person lets go of his or her hands,the molecule changes color. The research team put the molecule into a soft material. When the researchers stretched the material,it turned bright red for a few seconds before it broke into two pieces. When they repeatedly stretched and relaxed the material,without breaking it,it only turned a little red. The major problem is that light can get rid of the red color. When the team shone bright light on the molecule,the broken bond was fixed,and the color disappeared. If the bright light keeps the red color from appearing,the material's warning system will be useless. Scientists still have a lot of work to do before the colorchanging molecules can be used outside the lab.", "pos": "In this life, what did you miss? The wife asked the husband when she was 25. Despondently, the husband replied: 'I missed a new job opportunity.' When she was 35, the husband angrily told her that he had just missed the bus. At 45, the husband sadly said: 'I missed the opportunity seeing my closed relative before his last breath.' At 55, the husband said disappointingly: 'I missed a good chance to retire.' At 65, the husband hurriedly replied: 'I missed a dental appointment.' At 75, the wife did not ask the husband anymore, the husband was kneeling in front of the very sick wife. Remembering the question the wife used to ask him, this time he asked the wife the same question. The wife, with a smile and peaceful look, replied: 'In this life, I did not miss having you!' The husband was full of tears. He always thought that they could be together forever. He was always busy with work and trifles. So much so he had never been thoughtful to his wife. The husband hugged the wife tightly and said: 'Over 50 years, how I had allowed myself to miss your deep love for me.' In the busy city life, there are many people who are always busy with work. These people revolve their lives around their jobs, these people sacrifice all their times and health to meet the social expectations. They are unwilling to spend times on health care. They miss the opportunity to be with their children in their growing up. They neglect the loved ones who care for them, and also their health. Nobody knows what is going to happen one year from now. Life is not _ , so always live in the now. Express your gratitude to your loved ones in words. Show your care with actions. Treat everyday as the last episode of life. In this way, when you are gone, you loved ones would have nothing to feel sorry about.", "neg": "On April 20,2013, a big and powerful earthquake attacked Ya'an, Sichuan Province. A great many buildings and houses _ a lot of people were killed and even more people lost their homes in the earthquake . Death toll from the 7.0-magnitude earthquake that hit Ya'an in southwestern China's Sichuan Province has risen to 188 (as of 18:00 pm, April 22, ), according to latest calculations by local Civil Affairs Bureau. At least 11,826 were reportedly injured in the quake while 25 are still missing, the bureau said. Experts are anticipating much less casualties in the quake than that from the 8.0 magnitude quake hit Wenchuan on May 12, 2008, also in Sichuan Province, which killed more than 80,000 and injured over 300,000. Energy released from Wenchuan earthquake would be 30 times of that from Ya'an quake, according to Zhang Xiaonan, an expert with China's Geophysical Union. Dai Junwu with Harbin-based seismological bureau expects the death toll at less than 1,000, and economic losses from the quake could reach up to 100 billion yuan. Police and expert teams have already rushed for rescue in the quick stricken areas, and the State Council has banned unauthorized rescue efforts and individual vehicles from going to the quake zone to avoid congestion . Rescue efforts were carried \"timely and orderly\", said Chinese Premier Li Keqiang who flew to the quicken-stricken area on Sunday, the second day of the quake. He was quoted as saying that \"the current priority is to save lives\".", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}421{"query": "Si Renfa's son Si Jifa escaped and continued independent action in another corner of southwest Yunnan. He sent his younger brother Zhaosai to seek pardon from Ming while at the same time he attacked Ming troops in early 1443. However they were defeated and he was forced to flee to Mong Yang. Zhaosai was kept as a hostage and the Ming retreated from Mong Mao. Seeing that Mong Mao was no longer occupied, Si Jifa returned to his father's base of power and began attacking neighboring tribes once again. The third punitive expedition was led by Wang Ji and launched in March 1443. Although the mission was to capture Si Jifa, negotiations on the return of Si Renfa had fallen ill. Ava demanded Ming territory for itself and Hsenwi in return of Si Renfa. Furthermore Ava had made peace with Si Jifa. Therefore, although the Ming army quickly defeated Si Jifa's base of power and captured his family, Si Jifa managed to escape to Mong Yang, and the Ming army decided not to pursue out of consideration of a combined Ava-Hsenwi attack on Ming forces. A compromise was finally reached between Ava and Ming in April 1445. Ava agreed to hand over Si Renfa in return for Ming support in annexing part of Hsenwi's territory. Si Renfa came into Ming custody in August 1445 and was executed in January 1446.", "pos": "As Tsushima had suffered greatly from its loss of trade with Korea as a result of the invasions, Yoshitoshi of the So family, then dominant in Tsushima, undertook the lead in the peace negotiations by Japan. He sent four peace missions to Joseon in 1599 to normalize relations. The first three were captured and sent directly to Beijing by Chinese troops, but the fourth one, in 1601, successfully obtained from the Joseon court the promise of a normalizing of relations upon the return of remaining Joseon captives. As Ming troops continued to be present in Korea following the withdrawal of Japanese forces, the major incentive for Joseon for the normalization of relations with Japan was the withdrawal of the Chinese soldiers from their territory. The Ming Chinese themselves were causing as much havoc as the Japanese had during the actual conflict, and their presence continued to strain Joseon's national economy and infrastructure. In response to the Joseon request, Yoshitoshi promptly released several Joseon prisoners and between 1603 and 1604 helped the Joseon envoys to repatriate a further 3,000 by organizing negotiations at Kyoto with Tokugawa Ieyasu, by then the Shogun of Japan. In the continuation of the diplomatic talks toward peaceful relations, Joseon in 1606 expanded its conditions and demanded that the Shogun write a formal letter requesting peace, and to extradite the Japanese soldiers who had defiled the Joseon Royal Tombs near Hanseong . Realizing that the Shogunate would never agree to such a request, Yoshitoshi sent a forged letter and a group of criminals instead; the great need to expel the Ming soldiers pushed Joseon into accepting and to send an emissary in 1608. The end result was a return of Joseon prisoners and the restoration of diplomatic and trade relations between the two countries.", "neg": "The general Chinese history texts on the Ming Dynasty, including the Mingdai Shi and the Mingshi, briefly mention Cao Qin's failed coup of 1461. Cao Qin's coup and the events leading up to it were covered in Gao Dai's Hong you lu of 1573, Jiao Hong's Guochao Xianzheng lu of 1594-1616, the Huang Ming shi gai of 1632 and the Mingshi jishi benmo of 1658. Li Xian also wrote about Cao Jixiang's career in his \"Cao Jixiang zhi bian,\" featured in the Huang Ming mingchen jingji lu that was edited by Huang Xun in 1551.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}422{"query": "The Grandes etudes de Paganini, S. 141, are a series of six etudes for the piano by Franz Liszt, revised in 1851 from an earlier version (published as Etudes d'execution transcendante d'apres Paganini, S.140, in 1838).", "pos": "Musica ricercata is a set of eleven pieces for piano by Gyorgy Ligeti.", "neg": "Henry Fevrier was the father of the pianist Jacques Fevrier.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}423{"query": "Margaret Power is a fictional character in the Marvel Universe.", "pos": "Power Broker, Inc. is a fictional criminal corporation in the Marvel Universe which provides individuals with superhuman physical abilities for a price.", "neg": "The figure of a limp woman with long curly hair is seen drifting underwater, and a voiceover questions the end of a life that never truly existed. This life ended in murder, the victim herself unsure of who her killer was and why she was killed. Her death was only metaphorical, for in her place a new life begins.The story starts with Patience Phillips (Halle Berry), a timid woman who can't stand up for herself. She lets people walk all over her, and has wasted her artistic talent working for a cosmetic company as a graphic designer. George Hedare (Lambert Wilson) runs the company with his supermodel wife, Laurel (Sharon Stone). Laurel knows that Patience is capable, but seems mostly indifferent, only using her in own power struggles with her husband. George, an abusive boss in general, finds plenty of opportunity to mock Laurel.The company is about to launch BeauLine, a new anti-aging product that Laurel had secretly been using for years. The advertisement is designed by Patience but George, unsatisfied, demands that she redesigns it. Upset and frustrated, Patience returns home and sees a cat looking up at her. Shaking her head, she goes to sleep, but her loud neighbours keeps her up and she is unable to rest. Next morning, the cat is on her window ledge. When she approaches, she realizes the cat has climbed up to a higher ledge and was potentially stuck. To try and reach the cat, Patience climbs out her window ledge, and a passing detective mistakens her intentions as suicidal. He ends up rushing into her apartment and pulling her back in. Patience would have thanked him but realizes she is late for work, in her hurry to leave she drops her wallet. The detective, Tom Lone (Benjamin Bratt), tracks her down to her workplace and returns it to her, and both agree to a coffee date.Later that night, Patience goes to the production factory to deliver her artwork, and she accidentally hears that the BeauLine has unsafe health problems. Stunned, she backs into several tools, revealling her presence. Two men chase her into a large waste water pipe, where she is trapped, and they flush her into the river, where she drowns. The cat that has been appearing in front of Patience appears by her body and gathers several other cats around her.Patience eventually drags herself unsteadily up and returns home. Her movements are off and uncontrollable, and she ends up breaking the glass through her own window. When her neighbours start their usual loud party again, she yells at them to quiet but they again ignore her. The old Patience would have backed down, but now she strodes down, knocks on their door, and promptly beats up the host and destroys the music equipment in front of many shocked guests. When she wakes up the next morning, she almost dismisses everything as a dream until she sees the broken glass. Unfortunately, her memories of what happened before that are blank, and so she cluelessly returns back to work.At work, George loudly yells at Patience in front of all her coworkers for not handling in her project. She tunes him out, which angers him further, and when she apologizes he only continues. Patience than apologizes for wasting her time in the company, and is fired, but as soon as George leaves her colleagues swarm around her in congratulations. Patience packs up her things and while she and her friends are walking home, two dogs instantly begin barking at her and she instinctively hisses at them. When questioned, she explains her behaviour as allergies. When they pass by a jewelry store, Patience's attention is caught by a beautiful collar-like necklace, but is reminded of her new unemployed status and leaves longingly. Once home, she sees the same cat again, and finally close enough she was able to find the address on the cat's owner.The cat belonged to an older woman named Ophelia, a former professor who lived alone in a house full of cats. She explains that the cat constantly appearing in front of Patience is named Midnight, a rare Egyptian", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}424{"query": "The film tells the story of a psychiatrist, Dr. Cross (Vincent Price), who is treating a young woman, Janet Stewart (Anabel Shaw), who is in a coma-state, brought on when she heard loud arguing, went to her window and saw a man strike his wife with a candlestick and kill her. It also stars Lynn Bari as Dr. Cross's nurse/lover, Elaine Jordan. As Stewart comes out of her shock, she recognizes Dr. Cross as the killer. He then takes her to his sanitarium and at Elaine's urging, gives Janet an overdose of insulin under the pretense of administering insulin shock therapy. He can't bring himself to murder her in cold blood, though, and asks Elaine to get the medicine to save her. Elaine refuses, they argue, and he strangles her. A colleague of Dr. Cross, Dr. Harvey, saves Janet's life and Dr. Cross is taken into custody by a lawyer from the District Attorney's office.", "pos": "Webb Garwood (Van Heflin), a disgruntled cop, is called to investigate a voyeur by Susan Gilvray (Evelyn Keyes). Her husband works nights as an overnight radio personality. Webb falls in love with the young and attractive married woman. Obsessed, he woos her despite her initial reluctance and the two begin an adulterous affair. Webb finds out about an insurance policy on the husband's life. He dreams up a scheme in which a phantom \"prowler\" would be a good scapegoat if Susan's husband should happen to die mysteriously. After becoming a prowler himself, Webb \"investigates\" and then commits the murder, making it look like a tragic accident with he and the husband shooting at each other as each suspected the other of being the prowler. Webb's ruse fools a coroner's jury, thanks in part to both Susan and Webb testifying that they didn't know each other prior to her husband's death. Susan initially suspects Webb of foul play, but becomes convinced of his innocence and subsequently marries him. Shortly after the wedding, Susan informs Webb that she has been pregnant for four months. This is problematic because the date of the child's conception would prove the two had lied in their testimony to cover up their previous relationship, and would thus suggest that Webb's killing of Susan's husband had not been an accident. The two run away to a ghost town named Calico to have the baby without anyone back home knowing. Susan goes into premature labor and Webb finds a doctor, Dr. William James (Wheaton Chambers). Susan realizes that Webb intends to kill Dr. James to preserve their secret, so she warns the doctor who then escapes with the newborn. Susan tells Webb that she knows what he had planned to do and that she now realizes that he intentionally murdered her husband. Realizing the doctor will send the police after him, Webb drives away, leaving his wife in Calico alone. On the way out of town, he find the road blocked by his former partner on the police force who was coming to pay a visit. While attempting to get around his friend's car, Webb sees several police cars coming so he heads for the hills on foot. He refuses to stop and a sheriff's deputy shoots him dead.", "neg": "Paul Stanton (Mulroney) and his wife Diane (Diane Kruger) are a couple whose daughter is dying from a rare degenerative lung condition. The only thing that can save her life is a lung transplant from an organ donor. The movie starts when the donated lung fails to arrive correctly. The movie goes back and forth between the present and the events leading up to it. In the present day, Paul goes to Juarez, Mexico to find a man called Dr. Navarro. After leaving his cell number at many local hospitals, somebody finally contacts Paul. In the past, Dr. Rubin (Arquette), who's treating their daughter (Stallard), had given them information regarding Paul's associate, Harrison (Shepard), who somehow managed to get an organ transplant for himself, possibly from the black market. Paul confronted Harrison and finally managed to get Dr. Navarro's name from him. Harrison told him that he was contacted by Navarro and he didn't know how to reach him. Back in the present day, Paul is ambushed by a couple of Navarro's guys that tell him to stay away. After an arduous search, Paul finally finds out that Dr. Navarro is actually Dr. Martinez (Perez) from a local hospital that he visited previously for his wounds. Paul confronts Martinez and asks him to find a lung donor for his daughter, who only has one week to live. Martinez agrees to help him for a $250,000 cash payment. The next day, Martinez tells Paul that he has found a matching donor for his daughter. Paul tells Diane to go to Juarez and prepare their daughter for the transplant operation. Little does Paul know that the donor is actually a live person; Martinez and his men have planned a hit-and-run accident to get the lung implant from a local street boy. Paul discovers this fact and tells Diane about it. Diane tells him that she does not want to know where the donor comes from. Paul confronts Martinez at the operating table. Martinez tells Paul to make a choice: to go ahead with the operation or disband the operation knowing that they won't be able to find another match in time to save his daughter's life. The next scene shows Paul and Diane at their daughter's funeral. Diane gives Paul an accusing look blaming him for their daughter's death. Meanwhile, elsewhere, the local boy that was supposed to be the organ donor is alive and playing soccer with his friends.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}425{"query": "To investigate the clinical feature of Parkinson's disease (PD) with restless leg syndrome (RLS) and the pathogenesis of RLS. We conducted a cross-sectional and control study. The case group concluded 31 PD with RLS patients, meanwhile 39 PD patients were selected as the control group. Clinical history, clinical manifestations, complications and laboratory examinations were compared respectively between the two groups. All the RLS symptoms did not appear in RLS patients until the PD symptoms came out. Significant differences were found in complications such as swallow disturbance, constipation and illusion, when we compared the two PD groups (P < 0.05). Compared with the PD or healthy group, the level of serum ferritin and the H-reflex latency of tibial nerve were significantly decreased in PD with RLS group (P < 0.05). Secondary RLS is a complication of PD. Deficiency of iron and decreased inhibition function of spinal cord may lead to the occurrence of RLS in PD patients. When their motor symptoms are serious and complications are more common, PD patients are more possible to have RLS symptoms.", "pos": "Theories for restless legs syndrome (RLS) pathogenesis include iron deficiency, dopamine dysregulation and peripheral neuropathy. Increased prevalence of small intestinal bacterial overgrowth (SIBO) in controlled studies in RLS and case reports of post-infectious RLS suggest potential roles for inflammation and immunological alterations. A literature search for all conditions associated with RLS was performed. These included secondary RLS disorders and factors that may exacerbate RLS. All of these conditions were reviewed with respect to potential pathogenesis including reports of iron deficiency, neuropathy, SIBO, inflammation and immune changes. A condition was defined as highly-associated if there was a prevalence study that utilized an appropriate control group. Small case reports were recorded but not included as definite RLS-associated conditions. Fifty four diseases, syndromes and conditions have been reported to cause and/or exacerbate RLS. Of these, 38 have been reported to have a higher prevalence than age-matched controls, 9 have adequate sized reports and have general acceptance as RLS-associated conditions and 7 have been reported in case report form. Overall, 42 of the 47 RLS-associated conditions (89%) have also been associated with inflammatory and/or immune changes. In addition, 43% have been associated with peripheral iron deficiency, 40% with peripheral neuropathy and 32% with SIBO. Most of the remaining conditions have yet to be studied for these factors. The fact that 95% of the 38 highly-associated RLS conditions are also associated with inflammatory/immune changes suggests the possibility that RLS may be mediated or affected through these mechanisms. Inflammation can be responsible for iron deficiency and hypothetically could cause central nervous system iron deficiency-induced RLS. Alternatively, an immune reaction to gastrointestinal bacteria or other antigens may hypothetically cause RLS by a direct immunological attack on the central or peripheral nervous system.", "neg": "To investigate whether the effects of nerve growth factor (NGF) inhibition with tanezumab on rats with medial meniscal tear (MMT) effectively model rapidly progressive osteoarthritis (RPOA) observed in clinical trials. Male Lewis rats underwent MMT surgery and were treated weekly with tanezumab (0.1, 1 or 10mg/kg), isotype control or vehicle for 7, 14 or 28days. Gait deficiency was measured to assess weight-bearing on the operated limb. Joint damage was assessed via histopathology. A second arm, delayed onset of treatment (starting 3-8weeks after MMT surgery) was used to control for analgesia early in the disease process. A third arm, mid-tibial amputation, evaluated the dependency of the model on weight-bearing. Gait deficiency in untreated rats was present 3-7days after MMT surgery, with a return to normal weight-bearing by days 14-28. Prophylactic treatment with tanezumab prevented gait deficiency and resulted in more severe cartilage damage. When onset of treatment with tanezumab was delayed to 3-8weeks after MMT surgery, there was no increase in cartilage damage. Mid-tibial amputation completely prevented cartilage damage in untreated MMT rats. These data suggest that analgesia due to NGF inhibition during the acute injury phase is responsible for increased voluntary weight-bearing and subsequent cartilage damage in the rat MMT model. This model failed to replicate the hypotrophic bone response observed in tanezumab-treated patients with RPOA.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}426{"query": "Learn to Communicate with Others Talking to Teachers--Teachers are just people behind the desk, living breathing human beings. And they will probably be friendly to people who talk nicely to them. Teachers also seem to get along better with children who take schoolwork seriously and prepare for class. And, just like any other human being, teachers like to be appreciated. The next time your teacher helps you solve a math problem or figure out a science project, say thank you with a smile. Talking to Parents--Parents can be very supportive if their children ask for help. If you think there's something your parents can do to help you feel more comfortable around people, then ask them. Very often, parents want very much to help, but really don't know what to do. Pick a quiet time of the day and ask to talk. Tell them how you feel. Maybe they had the same trouble when they were kids. Talking to Strangers--This is always a tough one. How do you deal with a neighbor, or the mail carrier? That often seems to cause arguments between kids and parents. The answer to these questions will vary from kid to kid, from parent to parent because all cultures are different. Some folks live in small towns where a hello to everyone is ok. Then there are kids who live in the city who may have been taught not to speak to anyone they don't know. If you're having trouble with this and always feel awkward in these kinds of situations, you might want to talk to your parents or a teacher about it.", "pos": "While most teachers enjoy the summer break from work, other teachers try to find part-time work during that time. If you're one of those teachers who are finding part-time work during the summer, writing for children might be the right job you're looking for. During the school year, you're very familiar with children in your classroom. That means you know what children think about, how they talk and how they act. If you read stories and books for children with your students during the school year, you also know the kinds of story that children are fond of. As a teacher, you can go to the school library and find out what kinds of books students are most interested in. Also, what kinds of books seem to be in short supply? Use this information to create stories and novels. If you continue writing for children during the school year, you won't have enough time to write as much while you're teaching, but you can probably manage to work on at least one short story for children each month. Even if you don't finish these pieces during the school year, when school ends for the summer you will have lots of writing projects to finish and hand in to editors . Recently, many teachers have turned to writing for children as a part-time job. If you enjoy writing as much as you enjoy teaching, then writing for children might be the second job for you, too.", "neg": "In America, when the eighth graders leave the middle school, they are often worried about moving to the high school. It is a hard time for them, but it can be an exciting one as well. To make it easier, students need to get familiar with their school. Even though they've done this already in the middle school, it's still important to find where their classrooms are. Most schools take students to the high school for a visit at the end of their eighth grade year. And, most schools also have a freshman speech for parents and students before the first year begins. Sometimes the main office will give away a map of the school. This can help students and parents to find different places in the school. One way to know your high school more and make new friends is to join a club or play a sport. Schools often offer chances to join different clubs and sports. Fall activities begin in August before the first day of school. If you are not interested in sports, there are clubs for any interest, such as drama, dance, chess, photography, community service, etc. These clubs allow students from different grades. By joining an activity, students can find new friendships, not to mention improving their chances in future college applications . The school office will have a list of activities offered at the school and information on how to join them. What's more, to have a great start to a high school year, students can write down some of their worries, and ask for help from teachers and school workers.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}427{"query": "An alloy is a mixture of a metal with one or more other elements. The other elements may be metals, nonmetals, or both. An alloy is formed by melting a metal and dissolving the other elements in it. The molten solution is then allowed to cool and harden. Alloys generally have more useful properties than pure metals. Several examples of alloys are described and pictured below. If you have braces on your teeth, you might even have this alloy in your mouth! Click image to the left or use the URL below. URL: Most metal objects are made of alloys rather than pure metals. Objects made of four different alloys are shown in the Figure 1.1. Brass saxophone: Brass is an alloy of copper and zinc. It is softer than bronze and easier to shape. Its also very shiny. Notice the curved pieces in this shiny brass saxophone. Brass is used for shap- ing many other curved objects, such as doorknobs and plumbing fixtures. Stain- less steel sink: Stainless steel is a type of steel that contains nickel and chromium in addition to carbon and iron. It is shiny, strong, and resistant to rusting. This makes it useful for sinks, eating utensils, and other objects that are exposed to wa- ter. \"Gold\" bracelet: Pure gold is relatively soft, so it is rarely used for jewelry. Most \"gold\" jewelry is actually made of an alloy of gold, copper and silver. Bronze statue: Bronze was the first alloy ever made. The earliest bronze dates back many thou- sands of years. Bronze is a mixture of copper and tin. Both copper and tin are relatively soft metals, but mixed together in bronze they are much harder. Bronze has been used for statues, coins, and other objects. Q: Sterling silver is an alloy that is used to make fine jewelry. What elements do you think sterling silver contains? What properties might sterling silver have that make it more useful than pure silver? A: Most sterling silver is about 93 percent silver and about 7 percent copper. Sterling silver is harder and stronger than pure silver, while retaining the malleability and luster of pure silver.", "pos": "Metals are elements that are good conductors of electricity. They are the largest of the three classes of elements. In fact, most elements are metals. Look back at the modern periodic table (Figure 6.3) in this chapters lesson \"How Elements Are Organized.\" Find the metals in the table. They are all the elements that are color-coded blue. Examples include sodium (Na), silver (Ag), and zinc (Zn). Metals have relatively high melting points, so almost all are solids at room temperature. The only exception is mercury (Hg), which is a liquid. Most metals are also good conductors of heat. Thats why they are used for cooking pots and stovetops. Metals have other characteristic properties as well. Most are shiny, ductile, and malleable. These properties are illustrated in Figure 6.5. You can dig deeper into the properties of metals at this URL: Nonmetals are elements that do not conduct electricity. They are the second largest class of elements. Find the nonmetals in Figure 6.3. They are all the elements on the right side of the table that are color-coded green. Examples of nonmetals include helium (He), carbon (C), and oxygen (O). Nonmetals generally have properties that are the opposite of those of metals. They also tend to vary more in their properties than metals do. For example, nonmetals have relatively low boiling points, so many of them are gases at room temperature. But several nonmetals are solids, including carbon and phosphorus (P). One nonmetal, bromine (Br), is a liquid at room temperature. Generally, nonmetals are also poor conductors of heat. In fact, they may be used for insulation. For example, the down filling in a down jacket is mostly air, which consists mainly of nitrogen (N) and oxygen (O). These nonmetal gases are poor conductors of heat, so they keep body heat in and cold air out. Solid nonmetals are dull rather than shiny. They are also brittle rather than ductile or malleable. You can see examples of solid nonmetals in Figure 6.6. You can learn more about specific nonmetals with the interactive table at this URL: [Link] Metalloids are elements that fall between metals and nonmetals in the periodic table. Just seven elements are metalloids, so they are the smallest class of elements. In Figure 6.3, they are color-coded orange. Examples of metalloids include boron (B), silicon (Si), and germanium (Ge). Metalloids have some properties of metals and some properties of nonmetals. For example, many metalloids can conduct electricity but only at certain temperatures. These metalloids are called semiconductors. Silicon is an example. It is used in computer chips. It is also the most common metalloid on Earth. It is shiny like a metal but brittle like a nonmetal. You see a sample of silicon in Figure 6.7. The figure also shows other examples of metalloids. You can learn more about the properties of metalloids at this URL: [Link] From left to right across the periodic table, each element has one more proton than the element to its left. Because atoms are always electrically neutral, for each added proton, one electron is also added. Electrons are added first to the lowest energy level possible until that level is full. Only then are electrons added to the next higher energy level. The increase in electrons across the periodic table explains why elements go from metals to metalloids and then to nonmetals from left to right across the table. Look at period 2 in Figure 6.8 as an example. Lithium (Li) is a metal, boron (B) a metalloid, and fluorine (F) and neon (Ne) are nonmetals. The inner energy level is full for all four elements. This level has just one orbital and can hold a maximum of two electrons. The outer energy level is a different story. This level has four orbitals and can hold a maximum of eight electrons. Lithium has just one electron in this level, boron has three, fluorine has seven, and neon has eight. The", "neg": "A solution forms when one substance is dissolved by another. The substance that dissolves is called the solute. The substance that dissolves it is called the solvent. The solute is present in a lesser amount that the solvent. When the solute dissolves, it separates into individual particles, which spread throughout the solvent. Q: In bronze, what are the solute and solvent? A: Because bronze consists mainly of copper, copper is the solvent and tin is the solute. The two metals are combined in a hot, molten state, but they form a solid solution at room temperature. In the example of bronze, a solid (tin) is dissolved in another solid (copper). However, matter in any state can be the solute or solvent in a solution. For example, in a saltwater solution, a solid (salt) is dissolved in a liquid (water). The Table 1.1 describes examples of solutions consisting of solutes and solvents in various states of matter. Type of Solution: Example Gas dissolved in gas: dry air Gas dissolved in liquid: carbonated water Liquid dissolved in gas: moist air Liquid dissolved in liquid: vinegar Solid dissolved in liquid: sweet tea Solute oxygen carbon dioxide Solvent nitrogen water water acetic acid sugar air water tea Salt isnt the only solute that dissolves in water. In fact, so many things dissolve in water that water is sometimes called the universal solvent. Water is such a good solvent because it is a very polar compound. A polar compound has positively and negatively charged ends. Solutes that are also charged are attracted to the oppositely charged ends of water molecules. This allows the water molecules to pull the solute particles apart. On the other hand, there are some substances that dont dissolve in water. Did you ever try to clean a paintbrush with water after painting with an oil-based paint? It doesnt work. Oil-based paint is nonpolar, so its particles arent charged. As a result, oil-based paint doesnt dissolve in water. (You can see how to dissolve oil-based paint in the Figure 1.1.) These examples illustrate a general rule about solutes and solvents: like dissolves like. In other words, polar solvents dissolve polar solutes, and nonpolar solvents dissolve nonpolar solutes. You can see below a students video demonstrating solutes that do and solutes that dont dissolve in water. Click image to the left or use the URL below. URL: All solutes separate into individual particles when they dissolve, but the particles are different for ionic and covalent compounds. Ionic solutes separate into individual ions. Covalent solutes separate into individual molecules. Salt, or sodium chloride (NaCl), is an ionic compound. When it dissolves in water, it separates into positive sodium ions (Na+ ) and negative chloride ions (Cl ). You can see how this happens in the Figure 1.2. The negative oxygen ends of water molecules attract the positive sodium ions, and the positive hydrogen ends of water molecules attract the negative chloride ions. These forces of attraction pull the ions apart. The sugar glucose is a covalent compound. When sugar dissolves in water, it forms individual glucose molecules (C6 H12 O6 ). You can see how this happens in the Figure 1.3. Sugar is polar like water, so sugar molecules also have positive and negative ends. Forces of attraction between oppositely charged ends of water and sugar molecules pull individual sugar molecules away from the sugar crystal. Little by little, the sugar molecules are separated from the crystal and surrounded by water. Click image to the left or use the URL below. URL:", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}428{"query": "It is winter in many parts of the world. For some areas, that means snow. Maybe even lots of snow. If you don't have to drive in it or remove it, snow can be very beautiful. When snow covers everything around you, the world looks like a \"winter wonderland\". That is the name of a very popular song about winter. Richard Smith and Felix Bernard wrote the song back in 1934. There are hundreds of recordings of this happy song. But winter is not always such a beautiful and happy time. It's cold outside. You try hard to keep warm. The days are darker and shorter. The sun rarely shines. The leaves on the trees are brown. It isn't surprising that some people are sad in winter. And some people dream about being somewhere else where it's warm and pretty--like the state of California. The Mamas and the Papas recorded this famous song \"California Dreaming\". During the 1960s, many other famous rock groups released songs about winter. Here is a poetic song by Simon and Garfunkel called \"A Hazy Shade of Winter\". They sing about life and hope and possibilities. In 1968, the group Blood, Sweat and Tears recorded this gentle, sad song about winter. They sing about a lost love and forgotten memories in \"Sometimes in Winter\". In the early 1990s, Tori Amos wrote and recorded the beautiful song called \"Winter\". She enjoyed singing about winter when she was a child. Finally, on a happier note comes this song written and recorded by Fountains of Wayne in 2003. They sing about a snowstorm in a New England town. Nothing unusual there. But instead of being sad or tense about the snow, they write a song about it.", "pos": "Have you ever thought about why malls, restaurants, and even theaters have music? Well, to understand this, you simply just look back at how you felt when you heard music in these places. Music is known to improve the mood of people. Often music helps us pay attention to what we are doing. Music helps patients feel good and helps them recover faster and better. Depression is a state of mind that most of us experience at some point of time. There are some periods in our life when everything seems difficult. It seems that everything is getting worse and we have no control over our life. Studies have shown that music can be an important mood lifter in such situations. Music also plays a great role in making us feel less nervous or worried. Anxiety can often cause loss of sleep and other illnesses. Music is often known as an international language. We may not know the language another person is speaking, but most of us respond to music in the same way. Music can often be the best way to connect with someone. Music is one of the best ways to improve your moods, but this can depend largely on the kind of music you listen to. While happy music can certainly make you feel better, sad music can further lower your spirits. Listening to classical music can often make you feel a lot more powerful, while soft music can be the perfect way to relax at the end of a long way. If you want to use music to change the way how you are feeling, you need to understand the role of it, learn to recognize the kind of music that lifts your mood and helps you feel better. Once you realize the kind of music you can use, you can use it to change the way you feel. The right kind of music can be the perfect way to help us feel happier.", "neg": "The film depicts the construction and ultimate demolition of a metaphorical wall. Though the film's symbolism is open to interpretation, the wall itself clearly reflects a sense of isolation and alienation.Pink (Bob Geldof), the protagonist (and unreliable narrator) of the film, is a rock star, one of several reasons behind his apparent depressive and detached emotional state. He is first seen in a quiet hotel room, having trashed it. The opening music is not by Pink Floyd, but is the Vera Lynn recording of \"The Little Boy that Santa Claus Forgot\". During the following scenes, it is revealed that Pink's father, a British soldier, was killed in action during World War II during Pink's infancy. The reference is almost certainly to the death of Roger Waters' real-life father, Eric Fletcher Waters, who died in combat in Italy during Operation Shingle (the Battle of Anzio) in February 1944.The movie then flashes back to Pink as a young English boy growing up in the early 1950s. Throughout his childhood, Pink longs for a father figure after he learns his father died in the war. At school, he is humiliated by his mean and stern teacher for writing poems in class. The poems that the teacher seizes from him and reads aloud are lyrics from \"Money\" from the Pink Floyd album Dark Side of the Moon. Pink is also affected by his overprotective mother who spoils him by giving him whatever he wants.As an adult, Pink eventually gets married as his fame as a rock star grows, but he and his wife grow apart and she has an affair while Pink is on tour. When Pink learns of the affair, he compensates with expensive materialistic possessions and turns to a willing groupie (Jenny Wright), whom he brings back to his hotel room only to trash it in a fit of violence, causing her to flee the room in terror.Pink slowly begins to lose his mind to metaphorical \"worms\". He shaves off all of his body hair (an incident inspired by former bandmate Syd Barrett, who appeared at a 1975 recording session of Wish You Were Here, having shaved his eyebrows and body hair) and, while watching The Dam Busters on television, morphs into his neo-Nazi alter-ego. Pink's manager (Bob Hoskins), along with the hotel manager (Michael Ensign) and some paramedics, break into the hotel room and discover Pink. They take him away into a waiting limousine outside the hotel and inject him with drugs to enable him to perform.The drugs cause Pink to hallucinate and he fantasises that he is a neo-Nazi dictator, his concert is a rally. His followers proceed to attack ethnic minorities and rape the white girlfriend of a black man. Later, Pink holds a rally in suburban London, singing \"Waiting for the Worms\". The scene is inter-cut by images of animated marching hammers that goose-step across ruins.Pink screams \"Stop!\" and takes refuge in a bathroom stall at the concert venue, reciting poems which would later be used as lyrics on Pink Floyd's \"Your Possible Pasts\" from The Final Cut album and \"5:11 AM (The Moment Of Clarity)\" from Roger Waters' The Pros and Cons of Hitch Hiking.In a climatic animated sequence, Pink puts himself on trial. He is depicted as a small, pink rag doll that rarely moves. The judge is a giant pair of buttocks, with two backward facing legs, an anus for a mouth and a scrotum for a chin. The lawyer is a tall, menacing, vulturelike man and the schoolmaster is an abusive, hateful marionette. After hearing from the parties and witnesses (Pink's wife and mother), the judge orders the wall to be torn down. The wall explodes and shows a montage of events from the entire film.The film concludes with three children cleaning up a pile of debris after an earlier riot. It is unknown whatever has happened to Pink, leaving the viewer to decide.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}429{"query": "The deflated Giants traveled to Minnesota to take on the Vikings. Already eliminated from the playoffs due to Washington beating Philadelphia the night before to secure the NFC East for the first time since 2012, they were without their star wide receiver Odell Beckham Jr. as he was suspended for his actions in a Week 15 loss against Carolina. The Vikings stingy defense put pressure on Eli Manning all game, forcing Tom Coughlin to bench Manning after three interceptions. The Giants defense was not a factor as they failed to contain the Vikings rushing attack all game long. Linebacker JT Thomas was ejected from the game in the 4th quarter for throwing a punch. The loss of Beckham was too steep to overcome and the Giants wound up losing 49-17, dropping to 6-9.", "pos": "The Chiefs took an early lead on a 30-yard pass from Tyler Thigpen to Mark Bradley. The Chiefs defense continued to show improvement in the red zone, limiting the Chargers to two field goals instead of two touch downs. At the end of the first half, Thigpen threw a pass to 34yard touchdown pass to Tony Gonzalez. However, the extra point snap was botched and an attempt at a quick pass failed. The Chargers controlled the second half better than the first, scoring two touchdowns and leading the Chiefs by 7 at the end of the fourth quarter. The Chiefs' final drive ended with a 3-yard touchdown pass to Gonzalez. A 1-point PAT would tie the game. However, Herm Edwards told Thigpen to go for two, explaining in a post-game interview that the defense was too beat up for overtime play. The resulting two-point conversion ended in an incomplete pass. The Chiefs lost by one point.", "neg": "This game is well known for an infamous penalty that occurred during the overtime period. The Jets were lining up for a game winning 56-yard field goal in overtime to try and give them the win. Nick folk kicked the ball, but the kick went wide right and the Patriots appeared to be taking over with a chance to win. However, Chris Jones of New England was called for a controversial unsportsmanlike conduct penalty after pushing his teammate into the offensive line. This penalty would later be named \"leaping\". The penalty gave the Jets another chance and made the field goal attempt a 51-yard attempt. This time, Folk drilled the kick, and the Jets would go on to stun the Patriots. With the win, the Jets improved to 4-3.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}430{"query": "Ehlers-Danlos syndrome type 4, the vascular type, is a rare, life-threatening inherited disorder of the connective tissue. Affected patients are at risk of arterial, bowel and uterine rupture during pregnancy. Generally, this syndrome remains undiagnosed until a sudden, acute presentation with organ rupture, and results in premature death, even if the patients survive the first and second major complications. An early diagnosis with genetic assays can help to plan the best treatment, which is often challenging due to the frailty of the arterial tissue. We report on a 28-year-old lady who presented with spontaneous rupture of a pseudoaneurysm of the posterior tibial artery.", "pos": "Ehlers-Danlos syndrome (EDS), a heterogeneous group of inheritable connective tissue disorders, is attributed to mutations in connective tissue genes. These mutations cause defects in collagen. Collagen, a connective tissue protein that acts like glue, gives strength to the body and provides support and elasticity for movement. Thus, the altered gene affects the mechanical properties of skin, joints, ligaments, and blood vessels. Ehlers-Danlos syndrome is transmitted through autosomal dominant, autosomal recessive, or x-linked patterns of inheritance. The life expectancy of an affected infant varies with the type of EDS. This article provides an overview of the 6 major classifications of EDS, their unique clinical presentations, a focused physical assessment guide, considerations for nursing care, and resources for parents. Ehlers-Danlos syndrome can be a potentially debilitating syndrome. It requires preventative and protective measures starting at birth to preserve joint function to improve infant outcomes. Caring for patients with EDS requires an understanding of the potential associated complications to help minimize the physical and emotional impact of the syndrome and improve the quality of life for affected individuals.", "neg": "Heme is critical for a variety of cellular processes, but excess intracellular heme may result in oxidative stress and membrane injury. Feline leukemia virus subgroup C receptor (FLVCR1), a member of the SLC49 family of four paralogous genes, is a cell surface heme exporter, essential for erythropoiesis and systemic iron homeostasis. Disruption of FLVCR1 function blocks development of erythroid progenitors, likely due to heme toxicity. Mutations of SLC49A1 encoding FLVCR1 are noted in patients with a rare neurodegenerative disorder: posterior column ataxia with retinitis pigmentosa. FLVCR2 is highly homologous to FLVCR1 and may function as a cellular heme importer. Mutations of SLC49A2 encoding FLVCR2 are observed in Fowler syndrome, a rare proliferative vascular disorder of the brain. The functions of the remaining members of the SLC49 family, MFSD7 and DIRC2 (encoded by the SLC49A3 and SLC49A4 genes), are unknown, although the latter is implicated in hereditary renal carcinomas. SLC48A1 (heme responsive gene-1, HRG-1), the sole member of the SLC48 family, is associated with the endosome and appears to transport heme from the endosome into the cytosol.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}431{"query": "Josef Marek (born 11 June 1987) is a professional Czech football player who plays for FK Viktoria Zizkov.", "pos": "Luka orevic (Cyrillic: a , born 9 July 1994) is a Montenegrin footballer who plays as a forward for Spanish club SD Ponferradina on loan from FC Zenit Saint Petersburg.", "neg": "The Stadion pod Dubnom is an all-seater football stadium situated in Zilina, Slovakia, which is the home of MSK Zilina.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}432{"query": "Evaluate efficacy and safety of tanezumab, a humanized monoclonal antibody against nerve growth factor, in neuropathic pain. Two randomized controlled trials. Patients with pain due to diabetic peripheral neuropathy (DPN) or postherpetic neuralgia (PHN). In the DPN study, patients received subcutaneous tanezumab 20 mg or placebo on Day 1 and Week 8. Evaluations included change from baseline in average DPN pain (primary endpoint), Patient's Global Assessment of DPN, and safety (including neuropathy assessments). Due to a partial clinical hold limiting enrollment and treatment duration, the prespecified landmark analysis was modified post hoc from Week 16 to Week 8. In the PHN study, patients received intravenous tanezumab 50 g/kg, tanezumab 200 g/kg, or placebo on Day 1. Evaluations included change from baseline in average daily pain (primary endpoint), Brief Pain Inventory-short form, Patient's Global Assessment of pain from PHN, and safety. Mean DPN pain reduction from baseline to Week 8 was greater with tanezumab vs placebo (P = 0.009); differences in Patient's Global Assessment of DPN were not significant (P > 0.05). Neither tanezumab dose resulted in significant differences vs placebo in efficacy in PHN (P > 0.05), although tanezumab 200 g/kg provided some benefit. Neuropathy assessments showed no meaningful changes. Tanezumab provided effective pain reduction in DPN. In PHN, only the highest tanezumab dose reduced pain; treatment differences were not significant. No new safety concerns were observed despite preexisting neuropathy.", "pos": "Tanezumab is a humanized monoclonal antibody that specifically inhibits nerve growth factor as a treatment for chronic pain. This phase IIB study investigated the efficacy and safety of tanezumab for chronic low back pain vs placebo and naproxen. Patients (N=1347) received intravenous tanezumab (5, 10, or 20mg every 8weeks), naproxen (500mg twice daily), or placebo. The primary efficacy end point was mean change in daily average low back pain intensity (LBPI) from baseline to week 16. Secondary end points included mean change from baseline to week 16 in the Roland Morris Disability Questionnaire and Patient's Global Assessment (PGA) of low back pain. Tanezumab 10 and 20mg had similar efficacy profiles and significantly improved LBPI, Roland Morris Disability Questionnaire, and PGA scores vs both placebo and naproxen (P.05). Tanezumab 5mg provided improvement of PGA scores vs placebo (P.05), and naproxen resulted in significant improvement of LBPI vs placebo (P.05). Adverse event incidence was comparable across tanezumab doses but higher than with placebo or naproxen. Arthralgia, pain in extremity, headache, and paresthesia were the most commonly reported adverse events by tanezumab-treated patients. The most frequently reported adverse events resulting in discontinuation of tanezumab treatment were arthralgia and paresthesia; the highest frequency was observed with tanezumab 20mg (both 1.4%). Serious adverse event incidence was similar across treatments. In conclusion, tanezumab provided significantly greater improvement in pain, function, and global scores vs placebo and naproxen in patients with chronic low back pain.", "neg": "This was a 12-week randomized, placebo-controlled trial to assess the efficacy of quetiapine monotherapy in the treatment of posttraumatic stress disorder (PTSD). Eighty patients were randomly assigned to treatment with either quetiapine or placebo. The primary outcome measure was the Clinician-Administered PTSD Scale (CAPS). Secondary efficacy measures included the CAPS subscales, the Davidson Trauma Scale, the Positive and Negative Syndrome Scale (PANSS), the Clinical Global Impressions (CGI) scales for severity of Illness and improvement, the Hamilton Depression Rating Scale (HAM-D), and the Hamilton Anxiety Rating Scale (HAM-A). Safety measurements included adverse events, vital signs, the Abnormal Involuntary Movement Scale, the Barnes Akathisia Scale, the Simpson-Angus Scale, and the Arizona Sexual Experiences Scale. After a 1-week placebo run-in, quetiapine was started at a daily dosage of 25 mg and increased to a maximum of 800 mg; the average was 258 mg (range, 50-800 mg). Reductions in CAPS total, re-experiencing, and hyperarousal scores were significantly greater for the quetiapine group than for the placebo group. Greater improvements were also observed for quetiapine in scores on the Davidson Trauma Scale, CGI severity and improvement ratings, PANSS positive symptom and general psychopathology subscales, HAM-A, and HAM-D than for placebo. Adverse events were generally mild and expected based on prior studies of quetiapine in this and other patient population. There were no differences in safety measures between groups. Quetiapine monotherapy was efficacious in the treatment of PTSD. These findings suggest quetiapine as a single agent is effective in treating military PTSD.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}433{"query": "Chronic myeloid leukemia (CML) is characterized by the presence of the Philadelphia (Ph) chromosome, which results from a reciprocal translocation between the long arms of the chromosomes 9 and 22 t(9;22)(q34;q11). This translocation creates two new genes, BCR-ABL on the 22q- (Ph chromosome) and the reciprocal ABL-BCR on 9q-. The BCR-ABL gene encodes for a 210-kD protein with deregulated tyrosine kinase (TK) activity, which is crucial for malignant transformation in CML. The recognition of the BCR-ABL gene and corresponding protein led to the synthesis of small-molecule drugs, designed to interfere with BCR-ABL tyrosine kinase activation by competitive binding at the ATP-binding site. The first tyrosine kinase inhibitor (TKI), introduced into clinical practice in 1998, was imatinib mesylate. Imatinib became the first choice drug in chronic phase CML, because of its high efficacy, low toxicity and ability to maintain durable hematological and cytogenetic responses. However, approximately 20-25% of patients initially treated with imatinib will need alternative therapy, due to drug resistance, which is often caused by the appearance of clones expressing mutant forms of BCR-ABL. Second-generation TKIs have provided new therapeutic option for the patients resistant to imatinib. Dasatinib is the first, second-generation TKI, approved in the US and European Union for the treatment of CML patients with imatinib resistance or intolerance. This drug is a dual SRC-ABL kinase inhibitor, active in most clinically relevant BCR-ABL mutations, except highly resistant T315I. Other second-generation TKIs include nilotinib, bosutinib and INNO 406. Apart from TKIs, the promising group of molecules is inhibitors of Aurora family of serine-threonine kinases. One of these molecules, MK0457, has entered clinical trials, and initial reports indicate that this compound could be active in disease associated with T315I mutation. Thus, wide spectrum of new agents, with different mode of action, is currently in clinical development for CML. It is likely that combination therapy will be the best therapeutic strategy in the future.", "pos": "Imatinib mesylate is a new drug that can inhibit the tyrosine kinase activity of Bcr-Abl, the receptors for platelet-derived growth factor receptor(PDGF) and stem cell factor, or c-kit. Chronic myeloid leukemia (CML) is distinguished by the presence of a reciprocal translocation between chromosomes 9 and 22 that results in a shortened chromosome 22, termed the Philadelphia(Ph) chromosome. As a result of the translocation, a fusion gene called the Bcr-Abl gene is created from two normal cellular genes, encoding a chimeric Bcr-Abl protein with a deregulated tyrosine kinase activity. The expression of Bcr-Abl tyrosine kinase has been shown to be necessary and sufficient for the transformed phenotype of CML cells. Imatinib can block the kinase activity of Bcr-Abl, thus inhibiting the proliferation of Ph-positive progenitors, and has shown activity against all phases of CML, though responses are most substantial and durable in patients in the chronic phase. An international phase III study which compared the efficacy of imatinib with that of interferon alpha combined with low-dose cytarabine in newly diagnosed chronic-phase CML showed the rate of major cytogenetic response at 24 months was 90%, including 82% of complete cytogenetic response. These results indicated that imatinib was superior to interferon-containing treatment as a first-line therapy. More than 10,000 patients worldwide, including those in Japan, have been treated with imatinib in clinical trials, and a lot of information has been accumulated on the use of this drug. The aim of this article is to review the use of this drug and the practical management of patients with chronic myeloid leukemia.", "neg": "Batten disease [juvenile-onset neuronal ceroid lipofuscinosis (JNCL)], the most common progressive encephalopathy of childhood, is caused by mutations in a novel lysosomal membrane protein (CLN3) with unknown function. In this study, we have confirmed the lysosomal localization of the CLN3 protein by immunoelectron microscopy by co-localizing it with soluble and membrane-associated lysosomal proteins. We have analysed the intracellular processing and localization of two mutants, 461-677del, which is present in 85% of CLN3 alleles and causes the classical JNCL, and E295K [corrected], which is a rare missense mutation associated with an atypical form of JNCL. Pulse-chase labelling and immunoprecipitation of the two mutant proteins in COS-1-cells indicated that 461-677del is synthesized as an approximately 24 kDa truncated polypeptide, whereas the maturation of E295K [corrected] resembles that of the wild-type CLN3 polypeptide. Transient expression of the two mutants in BHK cells showed that 461-677del is retained in the endoplasmic reticulum, whereas E295K [corrected] was capable of reaching the lysosomal compartment. The CLN3 polypeptides were expressed further in mouse primary neurons where the wild-type CLN3 protein was localized both in the cell soma and in neuronal extensions, whereas the 461-677del mutant was arrested in the cell soma. Interestingly, co-localization of the wild-type CLN3 and E295K [corrected] proteins with a synaptic vesicle marker indicates that the CLN3 protein might participate in synaptic vesicle transport/transmission. The data presented here provide clear evidence for a cellular distinction between classical and atypical forms of Batten disease both in neural and non-neural cells.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}434{"query": "Soil is a complex mixture of different materials. About half of most soils are inorganic materials, such as the products of weathered rock, including pebbles, sand, silt, and clay particles. About half of all soils are organic materials, formed from the partial breakdown and decomposition of plants and animals. The organic materials are necessary for a soil to be fertile. The organic portion provides the nutrients, such as nitrogen, needed for strong plant growth. In between the solid pieces, there are tiny spaces filled with air and water. Within the soil layer, important reactions between solid rock, liquid water, air, and living things take place. In some soils, the organic portion could be missing, as in desert sand. Or a soil could be completely organic, such as the materials that make up peat in a bog or swamp (Figure 1.1). The inorganic portion of soil is made of many different size particles, and these different size particles are present in different proportions. The combination of these two factors determines some of the properties of the soil. A permeable soil allows water to flow through it easily because the spaces between the inorganic particles are large and well connected. Sandy or silty soils are considered \"light\" soils because they are permeable, water-draining types of soils. Soils that have lots of very small spaces are water-holding soils. For example, when clay is present in a soil, the soil is heavier, holds together more tightly, and holds water. When a soil contains a mixture of grain sizes, the soil is called a loam (Figure 1.2). A loam field. When soil scientists want to precisely determine soil type, they measure the percentage of sand, silt, and clay. They plot this information on a triangular diagram, with each size particle at one corner (Figure 1.3). The soil type can then be determined from the location on the diagram. At the top, a soil would be clay; at the left corner, it would be sand; at the right corner, it would be silt. Soils in the lower middle with less than 50% clay are loams. Soil types by particle size. Soil is an ecosystem unto itself. In the spaces of soil, there are thousands or even millions of living organisms. Those organisms could include earthworms, ants, bacteria, or fungi (Figure 1.4).", "pos": "How well soil forms and what type of soil forms depends on several different factors, which are described below. Scientists know that climate is the most important factor determining soil type because, given enough time, different rock types in a given climate will produce a similar soil (Figure 1.1). Even the same rock type in different climates will not produce the same type of soil. This is true because most rocks on Earth are made of the same eight elements and when the rock breaks down to become soil, those elements dominate. The same factors that lead to increased weathering also lead to greater soil formation. More rain equals more chemical reactions to weather minerals and rocks. Those reactions are most efficient in the top layers of the soil, where the water is fresh and has not yet reacted with other materials. Increased rainfall increases the amount of rock that is dissolved as well as the amount of material that is carried away by moving water. As materials are carried away, new surfaces are exposed, which also increases the rate of weathering. Climate is the most important factor in determining the type of soil that will form in a particular area. Increased temperature increases the rate of chemical reactions, which also increases soil formation. In warmer regions, plants and bacteria grow faster, which helps to weather material and produce soils. In tropical regions, where temperature and precipitation are consistently high, thick soils form. Arid regions have thin soils. Soil type also influences the type of vegetation that can grow in the region. We can identify climate types by the types of plants that grow there. The original rock is the source of the inorganic portion of the soil. The minerals that are present in the rock determine the composition of the material that is available to make soil. Soils may form in place or from material that has been moved. Residual soils form in place. The underlying rock breaks down to form the layers of soil that reside above it. Only about one-third of the soils in the United States are residual. Transported soils have been transported in from somewhere else. Sediments can be transported into an area by glaciers, wind, water, or gravity. Soils form from the loose particles that have been transported to a new location and deposited. The steeper the slope, the less likely material will be able to stay in place to form soil. Material on a steep slope is likely to go downhill. Materials will accumulate and soil will form where land areas are flat or gently undulating. Soils thicken as the amount of time available for weathering increases. The longer the amount of time that soil remains in a particular area, the greater the degree of alteration. The partial decay of plant material and animal remains produces the organic material and nutrients in soil. In soil, decomposing organisms breakdown the complex organic molecules of plant matter and animal remains to form simpler inorganic molecules that are soluble in water. Decomposing organisms also create organic acids that increase the rate of weathering and soil formation. Bacteria in the soil change atmospheric nitrogen into nitrates. The decayed remains of plant and animal life are called humus, which is an extremely important part of the soil. Humus coats the mineral grains. It binds them together into clumps that then hold the soil together, creating its structure. Humus increases the soils porosity and water-holding capacity and helps to buffer rapid changes in soil acidity. Humus also helps the soil to hold its nutrients, increasing its fertility. Fertile soils are rich in nitrogen, contain a high percentage of organic materials, and are usually black or dark brown in color. Soils that are nitrogen poor and low in organic material might be gray or yellow or even red in color. Fertile soils are more easily cultivated. Click image to the left or use the URL below. URL:", "neg": "To be a good aquifer, the rock in the aquifer must have good: porosity: small spaces between grains permeability: connections between pores To reach an aquifer, surface water infiltrates downward into the ground through tiny spaces or pores in the rock. The water travels down through the permeable rock until it reaches a layer that does not have pores; this rock is impermeable (Figure 1.1). This impermeable rock layer forms the base of the aquifer. The upper surface where the groundwater reaches is the water table. Groundwater is found beneath the solid surface. Notice that the water table roughly mirrors the slope of the lands surface. A well penetrates the water table. For a groundwater aquifer to contain the same amount of water, the amount of recharge must equal the amount of discharge. What are the likely sources of recharge? What are the likely sources of discharge? What happens to the water table when there is a lot of rainfall? What happens when there is a drought? Although groundwater levels do not rise and fall as rapidly as at the surface, over time the water table will rise during wet periods and fall during droughts. In wet regions, streams are fed by groundwater; the surface of the stream is the top of the water table (Figure 1.2). In dry regions, water seeps down from the stream into the aquifer. These streams are often dry much of the year. Water leaves a groundwater reservoir in streams or springs. People take water from aquifers, too. Groundwater meets the surface in a stream (Figure 1.2) or a spring (Figure 1.3). A spring may be constant, or may only flow at certain times of year. Towns in many locations depend on water from springs. Springs can be an extremely important source of water in locations where surface water is scarce. A well is created by digging or drilling to reach groundwater. It is important for anyone who intends to dig a well to know how deep beneath the surface the water table is. When the water table is close to the surface, wells are a convenient method for extracting water. When the water table is far below the surface, specialized equipment must The top of the stream is the top of the water table. The stream feeds the aquifer. A spring in Croatia bubbles to the surface and feeds the river Cetina. be used to dig a well. Most wells use motorized pumps to bring water to the surface, but some still require people to use a bucket to draw water up (Figure 1.4). An old-fashioned well that uses a bucket drawn up by hand.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}435{"query": "While the United States continued missions to the Moon in the early 1970s, the Soviets worked to build a space station. A space station is a large spacecraft. People can live on this craft for a long period of time. Between 1971 and 1982, the Soviets put a total of seven Salyut space stations into orbit. Figure 23.22 shows the last of these, Salyut 7. These were all temporary stations. They were launched and later inhabited by a human crew. Three of the Salyut stations were used for secret military purposes. The others were used to study the problems of living in space. Cosmonauts aboard the stations performed a variety of experiments in astronomy, biology, and Earth science. Salyut 6 and Salyut 7 each had two docking ports. One crew could dock a spacecraft to one end. A replacement crew could dock to the other end. The U.S. only launched one space station during this time. It was called Skylab. Skylab was launched in May 1973. Three crews visited Skylab, all within its first year in orbit. Skylab was used to study the effects of staying in space for long period. Devices on board were and for studying the Sun. Skylab reentered Earths atmosphere in 1979, sooner than expected. The first space station designed for long-term use was the Mir space station (Figure 23.23). Mir was launched in several separate pieces. These pieces were put together in space. Mir holds the current record for the longest continued presence in space. There were people living on Mir continuously for almost 10 years! Mir was the first major space project in which the United States and Russia worked together. American space shuttles transported supplies and people to and from Mir. American astronauts lived on Mir for many months. This cooperation allowed the two nations to learn from each other. The U.S. learned about Russias experiences with long-duration space flights. Mir was taken out of orbit in 2001. It fell into the Pacific Ocean. The International Space Station, shown in Figure 23.24 is a joint project between the space agencies of many nations These include the United States (NASA), Russia (RKA), Japan (JAXA), Canada (CSA), several European countries (ESA) and the Brazilian Space Agency. The International Space Station is a very large station. It has many different sections and is still being assembled. The station has had people on board since 2000. American space shuttles deliver most of the supplies and equipment to the station. Russian Soyuz spacecraft carry people. The primary purpose of the station is scientific research. This is important because the station has a microgravity environment. Experiments are done in the fields of biology, chemistry, physics, physiology and medicine. NASA wanted a new kind of space vehicle. This vehicle had to be reusable. It had to able to carry large pieces of equipment, such as satellites, space telescopes, or sections of a space station. The new vehicle was called a space shuttle, shown in Figure 23.25. There have been five space shuttles: Columbia, Challenger, Discovery, Atlantis, and Endeavor. A space shuttle has three main parts. You are probably most familiar with the orbiter. This part has wings like At the end of the mission, the orbiter re-enters Earths atmosphere. The outside heats up as it descends. Pilots have to steer the shuttle to the runway very precisely. Space shuttles usually land at Kennedy Space Center or at Edwards Air Force Base in California. The orbiter is later hauled back to Florida on the back of a jet airplane. The space shuttle program has been very successful. Over 100 mission have been flown. Space shuttle missions have made many scientific discoveries. Crews have launched many satellites. There have been other great achievements in space. However, the program has also had two tragic disasters. The first came just 73 seconds after launch, on January 28, 1986. The space shuttle Challenger disintegrated in mid-air, as shown in Figure 23.27. On board were seven crew members. All of them died. One of them was Christa McAuliffe, who was to be the first teacher in space.", "pos": "Why should mankind explore space? Why should money, time and effort be spent exploring and researching something with so few obvious benefits? Why should resources be spent on space rather than on conditions and people on Earth? These are questions that, understandably, are very often asked. Perhaps the best answer lies in our genetic makeup as human beings. What drove our ancestors to move from the trees into the plains, and on into all possible areas and environments? The wider the spread of a species, the better its chance of survival. Perhaps the best reason for exploring space is this genetic tendency to expand wherever possible. Nearly every successful civilization has explored, because by doing so, any dangers in surrounding areas can be identified and prepared for. Without knowledge, we may be completely destroyed by the danger. With knowledge, we can lessen its effects. Exploration also allows minerals and other potential resources to be found. Even if we have no immediate need of them, they will perhaps be useful later. Resources may be more than physical possessions . Knowledge or techniques have been gained through exploration. The techniques may have medical applications which can improve the length or quality of our lives. We have already benefited from other spin-offs including improvements in earthquake prediction, in satellites for weather forecasting and in communications systems. Even non-stick pans and mirrored sunglasses are by-products of technological developments in the space industry! While many resources are spent on what seems a small return, the exploration of space allows creative, brave and intelligent members of our species to focus on what may serve to save us. While space may hold many wonders and explanations of how the universe was formed or how it works, it also holds dangers. The danger exists, but knowledge can help human being to survive. Without the ability to reach out across space, the chance to save ourselves might not exist. While Earth is the only planet known to support life, surely the adaptive ability of humans would allow us to live on other planets. It is true that the lifestyle would be different, but human life and cultures have adapted in the past and surely could in the future.", "neg": "According to Finnish historians, the casualties of the Finnish Defence Forces amounted to 63,204 dead or missing and around 158,000 wounded. Officially, the Soviets captured 2,377 Finnish prisoners of war in the Soviet Union, although Finnish researchers estimated the number to be around 3,500 prisoners. 939 Finnish civilians died in air raids and 190 civilians were killed by Soviet partisans. Germany suffered approximately 84,000 casualties in the Finnish front, 16,400 killed, 60,400 wounded and 6,800 missing. In addition to the original peace terms of restoring the 1940 border, Finland was required to Finnish war reparations to the Soviet Union, conduct War-responsibility trials in Finland, lease Porkkalanniemi to the Soviets as well as ban fascist elements and allow left-wing groups, such as the Communist Party of Finland. A Soviet-led Allied Control Commission was installed to enforce and monitor the peace agreement in Finland. The requirement to disarm or expel any German troops left on Finnish soil by 15 September 1944 eventually escalated into the Lapland War between Finland and Germany and the evacuation of the 200,000-strong 20th Mountain Army to Norway.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}436{"query": "Sperm ( Figure 1.1), the male reproductive cells, are tiny. In fact, they are the smallest cells in the human body. What do you think a sperm cell looks like? Some people think that it looks like a tadpole. Do you agree? A sperm has three main parts: 1. The head of the sperm contains the nucleus. The nucleus holds the DNA of the cell. The head also contains enzymes that help the sperm break through the cell membrane of an egg. 2. The midpiece of the sperm is packed with mitochondria. Mitochondria are organelles in cells that produce energy. Sperm use the energy in the midpiece to move. 3. The tail of the sperm moves like a propeller, around and around. This tail is a long flagella that pushes the sperm forward. A sperm can travel about 30 inches per hour. This may not sound very fast, but dont forget how small a sperm is. For its size, a sperm moves about as fast as you do when you walk briskly. This drawing of a sperm shows its main parts. What is the role of each part? How do you think the shape of the sperm might help it swim? To make sperm, cells start in the testes and end in the epididymis. It takes up to two months to make sperm. The steps are explained below: 1. Special cells in the testes go through mitosis (cell division) to make identical copies of themselves. 2. The copies of the original cells divide by meiosis, producing cells called spermatids. The spermatids have half the number of chromosomes as the original cell. The spermatids are immature and cannot move on their own. 3. The spermatids are transported from the testes to the epididymis. Involuntary muscular contraction moves the spermatids along. 4. In the epididymis, spermatids slowly grow older and mature. They grow a tail. They also lose some of the cytoplasm from the head. It is here that the spermatids mature, becoming sperm cells. 5. When sperm are mature, they can swim. The mature sperm are stored in the epididymis until it is time for them to leave the body. Sperm leave the epididymis through the vas deferens. As they travel through the vas deferens, they pass by the prostate and other glands. The sperm mix with liquids from these glands, forming semen. The semen travels through the urethra and leaves the body through the penis. A teaspoon of semen may contain as many as 500 million sperm!", "pos": "The male reproductive organs include the penis, testes, and epididymis ( Figure 1.1). The figure also shows other parts of the male reproductive system. The penis is a cylinder-shaped organ. It contains the urethra. The urethra is a tube that carries urine out of the body. The urethra also carries sperm out of the body. This drawing shows the organs of the male reproductive system. It shows the organs from the side. Find each organ in the drawing as you read about it in the text. The two testes (singular, testis) are egg-shaped organs. They produce sperm and secrete testosterone. The testes are found inside of the scrotum. The scrotum is a sac that hangs down outside the body. The scrotum also contains the epididymis. The testes, being in the scrotum outside the body, allow the temperature of the sperm to be maintained at a few degrees lower than body temperature. This is necessary for the stability of these reproductive cells. The epididymis is a tube that is about six meters (20 feet) long in adults. It is tightly coiled, so it fits inside the scrotum. It rests on top of the testes. The epididymis is where sperm grow larger and mature. The epididymis also stores sperm until they leave the body. Other parts of the male reproductive system include the vas deferens and the prostate gland. Both of these structures are pictured below ( Figure 1.1). The vas deferens is a tube that carries sperm from the epididymis to the urethra. The prostate gland secretes a fluid that mixes with sperm to help form semen. The prostate gland is located beneath the bladder. Semen is a \"milky\" liquid that carries sperm through the urethra and out of the body. In addition to sperm cells, semen contains sugars (fructose) which provide energy to the sperm cells, and enzymes and other substances which help the sperm survive.", "neg": "Do you have imagination? Do you like to solve problems? Can you? If so, you could be the next great inventor. \"But I'm just a kid\",you might be! Don't worry about a little thing like age. For example, one famous inventor-- Benjamin Franklin--got his start when he was only 12. At that young age, he created paddles for his hands to help him swim faster. Finally his creation led to what we know is called flippers! So you don't have to be adult to be an inventor. One thing you do need, though, is something that kids have plenty of: curiosity and imagination. Kids are known for looking at things in new and unique ways. So what should you do if you have what is a great idea for an invention? Talk to a friend or family member about it. Get input from others about your idea. Then ask them to help you create a working model--called a prototype of your idea. Once you have a prototype, you can test it. Sometimes your idea turns out to be not as great as you thought. At other times, though, you realize it is a good idea and your prototype can help you figure out how to make it even better. If your idea is really a good one, an adult can help you contact companies that might be interested in it. You will also want an adult's help to get a patent for your idea, so that it is protected and can't be stolen by someone else. If you need some inspiration, consider these kids and their inventions: Jeanie Low invented the Kiddie Stool when she was just 11. It's a folding stool that fits under the kitchen sink. Kids can unfold it and use it to reach the sink all by themselves. At the age of 15, Louis Braille invented the system named after him that allows the blind to read. Chelsea Lanmon received a patent when she was just 8 for the \"pocket diaper \",a new type of diaper that includes a pocket for holding baby wipes and powder.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}437{"query": "The Antinous Farnese is a specific marble sculptural representation of Antinous, named after its one-time owners the Farnese family.", "pos": "Boy with Thorn, also called Fedele (Fedelino) or Spinario, is a Greco-Roman Hellenistic bronze sculpture of a boy withdrawing a thorn from the sole of his foot, now in the Palazzo dei Conservatori, Rome.", "neg": "The Bearded Slave (Italian: Schiavo barbuto) is a marble sculpture by Michelangelo datable to around 1525--1530 and kept in the Galleria dell'Accademia in Florence.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}438{"query": "The movie opens with spoofing \"Armageddon\" and \"10,000 B.C.\" In the year 10,001 B.C., a caveman Will (Matt Lanter) runs away from a mammoth before getting in a fight with Wolf (Ike Barinholtz). He then encounters a saber-toothed, gasoline-drinking Amy Winehouse (Nicole Parker), who informs him that the world will end on August 29, 2008 (which was the film's opening day and Michael Jackson's 50th birthday), revealing their fate laying in a crystal skull \"Indiana Jones\". The film flash-forwards to the present, where Will apparently dreamed all of this. He then finds out that his girlfriend, Amy (Vanessa Minnillo), is having an affair with Flavor Flav (Abe Spigner) and the two break up with Will not admitting his true feelings for her.Later that day, Will has a \"Sweet Sixteen\" party at his house, despite the fact that he's 25. Among the guests are Juney (Crista Flanagan) spoof of \"Juno\" and Will's best friend Calvin (Gary \"G-Thang\" Johnson), who attempts to curve a bullet around the room \"Wanted\" to stop Seth and McLover \"Superbad\" (Noah Harpster and Austin Scott) from stealing the alcohol, accidentally killing \"Dr. Phil\" (John Di Domenico), Anton Chigurh (Barinholtz), and the Beautiful Assassin (Carmen Electra) in the process. By then, Amy arrives with her new boyfriend, an underwear model (Nick Steele), before the \"High School Musical\" number is performed with cameos by an off-key Jessica Simpson (Parker) and Justin Timberlake (Jonas Neal).However, the party comes to a halt when the lights go out as the room shakes and a bulletin on the radio claims that it is the end of the world. Will, Juney, Calvin and his girlfriend Lisa (Kim Kardashian) go outside during a meteor shower and find that \"Hannah Montana\" (Flanagan) has been crushed by a meteor and, even when caught between life and death, is still promoting her merchandise until her wig falls off, revealing her as Miley Cyrus before she finally dies. While this occurred, a kid (Ty Wesley) wakes up \"Hancock\" (Walter Harris) and mouths at him to go save the world, only to be knocked away as Hancock tries to flee the city but hits his head on a streetlight and knocks himself out. Soon after, the city starts to freeze over, and the group retreats to a garage for shelter. They meet the \"Sex and the City\" girls, who claim to have first grabs and Juney beats a drag queen version of Carrie Bradshaw (Jason Boegh) for the garage \"Don't Mess With The Zohan\". After discussing global warming, Calvin says that he is cold and suggests they take their clothes off. Only the girls take their clothes off, and the guys stare in awe until Juney's water broke.Later, Will has a dream where he is a \"Jumper\" and accidentally impales himself on Prince Caspian's (Barinholtz) sword (Caspian identifies him as \"the guy who ruined Star Wars\"; also a reference to Matt Lanter's voice role as Anakin Skywalker in the 2008 CGI Clone Wars television series). After Will's dream ended and he was chided for not even trying to commit to his relationship, the gang leaves the garage and Will gets a call from Amy, admitting his feelings for her before he decides to get to her as Lisa gets killed by a meteor. While the others comfort a distraught Calvin, the \"Enchanted\" Princess climbs out of a manhole and gets hit by a taxi, with Calvin catching her as they immediately fall in love with each other. Juney guesses she's a princess thrown out of her kingdom by an evil witch, the Princess explains that she's a \"demented homeless chick who lives in the sewers\" due to consuming \"lots and lots and lots of mind-altering, enchanting drugs!\" After getting into a dance off with the Princess's Princely pimp dancing to Sizzle C's 'I Like", "pos": "Vanessa Snyder (Alexa Vega) is an admired eighth-grader in her school. She has a loving single mother, Barbara (Lisa Vidal), who is proud of her well-placed daughter. Vanessa is also \"in\" with the popular clique, led by her best friend Stacy Larson (Leah Pipes), the queen bee, and Nikki Rodriguez (Elizabeth Rice), who is secretly jealous of Stacy and Vanessa's closeness. On the exterior of this exclusive friendship circle is the outsider, Emily (Shari Dyon Perry), and the wannabe, Tiffany (Alicia Morton), who is dying to make it into the pack.The nightmare begins when Nikki tricks Vanessa into getting close to Tony (Chad Biagini), a boy whom Stacy (and somewhat Vanessa) has a crush on. A web of lies, nasty rumors, and manipulation ensues, and Vanessa is ostracized by the clique for \"backstabbing\" Stacy. Helpless, Vanessa soon faces the conflict and violence from her former friends and other popular girls whom she doesn't even know. Nikki gets Tiffany accepted into the clique, and Tiffany becomes Nikki's sidekick at poisoning the others against Vanessa. Although Nikki is the main girl who is tormenting Vanessa, Stacy plays her part by pretending she's still Vanessa's best friend and not stopping the attacks on her. Vanessa is slowly pushed out of class activities, called names, socially isolated and worst of all, her tormentors create a webpage about her on which they put humiliating photos of Vanessa, along with expressions of hatred towards her.Emily tries to convince Vanessa not to go running back to the clique, but Vanessa keeps attempting to seek reconciliation with Stacy, to disastrous results. The bullying escalates, with Stacy, Nikki, Tiffany and others cornering Vanessa inside a bathroom and verbally brutalizing her, including degrading every aspect of her and revealing her embarrassing secrets. That night, Vanessa has a nervous breakdown and chops all her hair off. Then she starts skipping school, fearing the agony in the hallways. Stacy offers a fake truce to Vanessa and asks for help on an assignment. Vanessa sends Stacy her paper, only to have Stacy copy it and make it look like Vanessa copied Stacy's paper.Once Vanessa shows her mother a print-out of comments about Vanessa's hair, Barbara tries to help by informing the school about the bullying, to no avail as the principal is unable to take disciplinary action against non-physical bullying. Barbara even tries to talk to Stacy's mother, Denise (Rhoda Griffis) but only ends up straining their friendship. Even an adult like Barbara is helpless in the face of teen violence.Vanessa's spirits are suddenly lifted when Stacy invites her to her birthday party. After preparing, she arrives at a club, which is not the site of the party. When discovering this, Vanessa goes ballistic. She takes an overdose of her mother's sleeping pills, but survives and just passes out.In the hospital, Barbara reveals to her daughter that she was also emotionally bullied when she was a teenager, which caused her to encourage Vanessa to stay friends with Stacy. She says that she never dealt with it herself and wished Vanessa would learn self-defense.During a class session, Emily accuses Stacy of nearly killing Vanessa for her actions. She is also the only one of Vanessa's classmates to visit her in the hospital and befriends her.Back home, Barbara spots malicious instant messages popping up on Vanessa's computer and sends them to the school principal. The culprits have been revealed to be Nikki, Tiffany, and Ezra (Joey Nappo), another tormentor. If they deny that they cyber-bullied Vanessa, they would be expelled from the school and not graduate. When Vanessa returns to school, she and Stacy reunite after Stacy convinces her that she's sorry about the bullying. They IM each other about how great it feels to be best friends again. Then graduation day comes and the final conflict happens when after the graduation, Nikki and Tiffany read aloud the chat between Vanessa and Stacy, which Stacey had sent to Nikki, and which Nikki had printed out.", "neg": "Paul Stanton (Mulroney) and his wife Diane (Diane Kruger) are a couple whose daughter is dying from a rare degenerative lung condition. The only thing that can save her life is a lung transplant from an organ donor. The movie starts when the donated lung fails to arrive correctly. The movie goes back and forth between the present and the events leading up to it. In the present day, Paul goes to Juarez, Mexico to find a man called Dr. Navarro. After leaving his cell number at many local hospitals, somebody finally contacts Paul. In the past, Dr. Rubin (Arquette), who's treating their daughter (Stallard), had given them information regarding Paul's associate, Harrison (Shepard), who somehow managed to get an organ transplant for himself, possibly from the black market. Paul confronted Harrison and finally managed to get Dr. Navarro's name from him. Harrison told him that he was contacted by Navarro and he didn't know how to reach him. Back in the present day, Paul is ambushed by a couple of Navarro's guys that tell him to stay away. After an arduous search, Paul finally finds out that Dr. Navarro is actually Dr. Martinez (Perez) from a local hospital that he visited previously for his wounds. Paul confronts Martinez and asks him to find a lung donor for his daughter, who only has one week to live. Martinez agrees to help him for a $250,000 cash payment. The next day, Martinez tells Paul that he has found a matching donor for his daughter. Paul tells Diane to go to Juarez and prepare their daughter for the transplant operation. Little does Paul know that the donor is actually a live person; Martinez and his men have planned a hit-and-run accident to get the lung implant from a local street boy. Paul discovers this fact and tells Diane about it. Diane tells him that she does not want to know where the donor comes from. Paul confronts Martinez at the operating table. Martinez tells Paul to make a choice: to go ahead with the operation or disband the operation knowing that they won't be able to find another match in time to save his daughter's life. The next scene shows Paul and Diane at their daughter's funeral. Diane gives Paul an accusing look blaming him for their daughter's death. Meanwhile, elsewhere, the local boy that was supposed to be the organ donor is alive and playing soccer with his friends.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}439{"query": "We have dreams almost every night. Do you ever notice the colors of your dreams? Do you dream in black and white or do you dream in yellow, red and green? New research suggests that the type of television you watched as a child has a great effect on the color of your dreams. While almost all people under 25 dream in color, thousands of people over 55, all of whom were brought up with black and white TV sets, often dream in monochrome . \"It suggests there could be a critical period in our childhood when watching films has a big impact on the way dreams are formed\", said Eva Murzyn, a psychology student at Dundee University in Britain who carried out the study. Research from 1915 through the 1950s suggested that the vast majority of dreams are in black and white. But the tide turned in the sixties, and later results suggested that up to 83 percent of dreams contain some color. Since this period also marked the transition between black-and-white film and TV and Technicolor ,an obvious explanation was that the media had been painting people's dreams. However, there weren't any firm conclusions. But now Miss Murzyn believes she has proven the link. She made a survey of more than 60 people, half of whom were over 55 and half of whom were under 25. She asked the volunteers to answer a questionnaire on the color of their dreams and their childhood exposure to film and TV. She then analyzed her own data. Only 4.4 percent of the under-25s' dreams were black and white. The over-55s who had had access to color TV and film during their childhood also reported a very low proportion of just 7.3 percent. But the over-55s who only had access to black-and -white media reported dreaming in black and white about a quarter of the time. Even though they would have spent only a few hours a day watching TV or films, their attention and emotion would have been heightened during this time, leaving a deeper imprint on their mind, Miss Murzyn told the New Scientist. \"The crucial time is between three and ten when we all begin to have the ability to dream\", she said.", "pos": "In a time when a dangerous number of people are overweight, many people seem to have forgotten the most important way to keep healthy and slim---exercise. And as a new study carried out on mice in the lab has shown, exercise done early in life can reward you in your adult years. A team of researchers at the University of California studied the effects of early exercise on adult physical activity, body mass and eating. They found that early-age exercise in mice has positive effects on adult levels of voluntary exercise in addition to reducing body mass. \"These results may have an effect on the importance of regular physical education in elementary and middle schools,\" said Theodore Garland, a professor of biology, who led the research project. \"If kids exercise regularly through their school years, then they may be more likely to exercise as adults, which could have far-reaching positive effects on human health and well-being.\" Although the positive effects of early-life exercise lasted for only one week, it is important to note that one week in the life of a mouse is the same as about nine months for humans. \"Our results suggest that any positive effects of early-life exercise on adult exercise will need to be kept up if they are to be long-lasting.\" His team of researchers found, too, that all mice that had access to early exercise were lighter in weight than non-exercised mice. Garland explained that, in general, exercise will stimulate appetite sooner or later. However, it is possible that certain types of exercise, done for certain periods of time or at certain light levels, might not _ appetite much, if at all, at least in some individuals. \"If we could understand what sorts of exercise these might be, then we might be able to tailor exercise recommendations in a way that would bring the benefits of exercise without increase in appetite, leading to a better chance of weight loss,\" he said.", "neg": "The ability to see is called vision. It depends on both the eyes and the brain. The eyes sense light and form images. The brain interprets the images formed by the eyes and tells us what we are seeing. For a fascinating account of how the brain helps us see, watch this short video: . MEDIA Click image to the left or use the URL below. URL: Did you ever use 3-D glasses to watch a movie, like the teens in Figure 20.11? If you did, then you know that the glasses make images on the flat screen seem more realistic by giving them depth. The images seem to jump right out of the screen toward you. Unlike many other animals, human beings and other primates normally see the world around them in three dimen- sions. Thats because we have two eyes that face the same direction but are a few inches apart. Both eyes focus on the same object at the same time but from slightly different angles. The brain uses the different images from the two eyes to determine the distance to the object. Human beings and other primates also have the ability to see in color. We have special cells inside our eyes that can distinguish different wavelengths of visible light. Visible light is light in the range of wavelengths that the human eye can sense. The exact wavelength of visible light determines its color. The function of the eye is to focus light and form images. We see some objects, such as stars and light bulbs, because they give off their own light. However, we see most objects because they reflect light from another source such as the sun. We form images of the objects when some of the reflected light enters our eyes. Look at the parts of the eye in Figure 20.12. Follow the path of light through the eye as you read about it below. 1. Light from an object passes first through the cornea. This is a clear, protective covering on the outside of the eye. 2. Then light passes through the pupil, an opening in the center of the eye. The pupil, which looks black, is surrounded by the colored part of the eye, called the iris. 3. Light entering through the pupil next passes through the lens. The lens is a clear, curved structure, like the lens of a magnifying glass. Along with the cornea, the lens focuses the light on the back of the eye. 4. The back of the eye is covered by a thin layer called the retina. This is where the image of the object normally forms. The retina consists of special light-sensing cells called rods and cones. Rods sense dim light. Cones sense different colors of light. 5. Nerve impulses from rods and cones travel to the optic nerve. It carries the nerve impulses to the brain. You probably know people who need eyeglasses or contact lenses to see clearly. Maybe you need them yourself. Lenses are used to correct vision problems. Two of the most common vision problems in young people are myopia and hyperopia. You can compare myopia and hyperopia in Figure 20.13. To learn about astigmatism, another common vision problem, watch this very short video: . MEDIA Click image to the left or use the URL below. URL: Myopia is commonly called nearsightedness. People with myopia can see nearby objects clearly, but distant objects appear blurry. Myopia occurs when images focus in front of the retina because the eyeball is too long. This vision problem can be corrected with concave lenses, which curve inward. The lenses focus images correctly on the retina. Hyperopia is commonly called farsightedness. People with hyperopia can see distant objects clearly, but nearby objects appear blurry. Hyperopia occurs when images focus in back of the retina because the eyeball is too short. This vision problem can be corrected with convex lenses, which curve outward. The lenses focus images correctly on the retina. Vision is just one of several human senses. Other human senses include hearing, touch, taste, and smell. Imagine shopping at the fruit market in Figure 20.14. It would stimulate all of these senses. You would hear the", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}440{"query": "Week 8 saw the Bears return to Soldier Field to play the San Francisco 49ers. Prior to the game, Lovie Smith announced that the Bears would don their alternative orange jerseys to commemorate the upcoming Halloween holiday, and asked Bear fans to wear orange clothing to create an \"orange swarm\" at Soldier Field. The Bears' 41 point first half tied the franchise record for most points scored in one half, the other game being the 1940 NFL Championship, where the Bears defeated the Washington Redskins 73-0.", "pos": "The Packers were trailing the winless Cleveland Browns 14-7 in the third quarter. The Browns scored a touchdown to make it 21-7, but Hundley and the Packers responded with a touchdown drive of their own, making it 21-14. The Packers tied the game with 17 seconds left on a touchdown pass to Davante Adams. In overtime, Browns quarterback DeShone Kizer threw a costly interception to Josh Jones, and Adams took a screen pass to the end zone, improving the Packers record to 7-6 and setting the stage for Aaron Rodgers' comeback.", "neg": "In Week 8, the Bears donned their 1940s throwback uniforms against the Carolina Panthers, who had the worst record in the NFC. The Bears scored first on Matt Forte's 13-yard touchdown run, which would be countered by Justin Medlock's 34-yard field goal. The Panthers then took the lead on Louis Murphy's fumble recovery; Panthers quarterback Cam Newton ran with the ball, and lost the ball when Bears safety Major Wright tackled him at the 1-yard line. The ball rolled into the endzone, where Murphy recovered it. Medlock would then kick three more field goals, and by the fourth quarter, the Panthers led 19-7. The tide eventually turned when Panthers punter Brad Nortman shanked a 6-yard punt, and Jay Cutler hit Kellen Davis on a 12-yard touchdown pass with less than seven minutes left in the game. On the first play of the Panthers' next drive, Tim Jennings intercepted Newton and returned the pick 25 yards to regain the lead 20-19, after Cutler's two-point conversion passing attempt was intercepted. Medlock later kicked another field goal to reclaim the lead 22-20 with 2:27 left in the game. Cutler would lead the Bears downfield, and Gould kicked a 41-yard field goal as time expired to give Chicago the victory. The kick was Gould's tenth game-winning field goal, and the first since 2010.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}441{"query": "The discovery of the Hippo pathway can be traced back to two areas of research. Genetic screens in fruit flies led to the identification of the Hippo pathway kinases and scaffolding proteins that function together to suppress cell proliferation and tumor growth. Independent research, often in the context of muscle biology, described Tead (TEA domain) transcription factors, which bind CATTCC DNA motifs to regulate gene expression. These two research areas were joined by the finding that the Hippo pathway regulates the activity of Tead transcription factors mainly through phosphorylation of the transcriptional coactivators Yap and Taz, which bind to and activate Teads. Additionally, many other signal transduction proteins crosstalk to members of the Hippo pathway forming a Hippo signal transduction network. We discuss evidence that the Hippo signal transduction network plays important roles in myogenesis, regeneration, muscular dystrophy, and rhabdomyosarcoma in skeletal muscle, as well as in myogenesis, organ size control, and regeneration of the heart. Understanding the role of Hippo kinases in skeletal and heart muscle physiology could have important implications for translational research.", "pos": "Calcineurin signaling has been implicated in a broad spectrum of developmental processes in a variety of organ systems. Calcineurin is a calmodulin-dependent, calcium-activated protein phosphatase composed of catalytic and regulatory subunits. The serine/threonine-specific phosphatase functions within a signal transduction pathway that regulates gene expression and biological responses in many developmentally important cell types. Calcineurin signaling was first defined in T lymphocytes as a regulator of nuclear factor of activated T cells (NFAT) transcription factor nuclear translocation and activation. Recent studies have demonstrated the vital nature of calcium/calcineurin/NFAT signaling in cardiovascular and skeletal muscle development in vertebrates. Inhibition, mutation, or forced expression of calcineurin pathway genes result in defects or alterations in cardiomyocyte maturation, heart valve formation, vascular development, skeletal muscle differentiation and fiber-type switching, and cardiac and skeletal muscle hypertrophy. Conserved calcineurin genes are found in invertebrates such as Drosophila and Caenorhabditis elegans, and genetic studies have demonstrated specific myogenic functions for the phosphatase in their development. The ability to investigate calcineurin signaling pathways in vertebrates and model genetic organisms provides a great potential to more fully comprehend the functions of calcineurin and its interacting genes in heart, blood vessel, and muscle development.", "neg": "Differentiation of cancer stem cells (CSCs) into cancer cells causes increased sensitivity to chemotherapeutic agents. Although inhibition of mammalian target of rapamycin (mTOR) leads to CSC survival, the effect of branched chain amino acids (BCAAs), an mTOR complex 1 (mTORC1) activator remains unknown. In this study, we examined the effects of BCAA on hepatocellular carcinoma (HCC) cells expressing a hepatic CSC marker, EpCAM. We examined the effects of BCAA and/or 5-fluorouracil (FU) on expression of EpCAM and other CSC-related markers, as well as cell proliferation in HCC cells and in a xenograft mouse model. We also characterized CSC-related and mTOR signal-related molecule expression and tumorigenicity in HCC cells with knockdown of Rictor or Raptor, or overexpression of constitutively active rheb (caRheb). mTOR signal-related molecule expression was also examined in BCAA-treated HCC cells. In-vitro BCAA reduced the frequency of EpCAM-positive cells and improved sensitivity to the anti-proliferative effect of 5-FU. Combined 5-FU and BCAA provided better antitumor efficacy than 5-FU alone in the xenograft model. Stimulation with high doses of BCAA activated mTORC1. Knockdown and overexpression experiments revealed that inhibition of mTOR complex 2 (mTORC2) or activation of mTORC1 led to decreased EpCAM expression and little or no tumorigenicity. BCAA may enhance the sensitivity to chemotherapy by reducing the population of cscs via the mTOR pathway. This result suggests the utility of BCAA in liver cancer therapy.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}442{"query": "An overdose of oral anticoagulants represents a challenging scenario for emergency physicians. Dabigatran, an oral direct thrombin inhibitor, is increasingly used in place of warfarin. The lack of an antidote is a concern in patients who overdose on dabigatran, even though the drug can be eliminated with hemodialysis. Idarucizumab is an antibody fragment that binds dabigatran with high affinity. It reverses the anticoagulant effect of dabigatran within minutes and is approved for the reversal of dabigatran during emergency situations. We describe the use of idarucizumab in the management of a 68-year-old woman who was taking dabigatran 150mg twice daily and ingested 125 capsules. Despite gastric lavage and administration of activated charcoal within two hours of drug intake, the activated partial thromboplastin time (aPTT) and prothrombin time (PT) remained prolonged. The administration of 5g of intravenous idarucizumab promptly and completely reversed the anticoagulant activity of dabigatran as assessed by routine and specific coagulation assays (aPTT from to 75 to 26s, PT from 26 to 11s and diluted thrombin time from 92 to 27s). The initially planned emergency hemodialysis was canceled. This case highlights the potential use of idarucizumab for the management of massive dabigatran overdoses.", "pos": "Anticoagulation therapy is indicated for management of various clinical conditions to prevent adverse events and introduction of direct oral anticoagulants (DOACs) has ushered in a new era in anticoagulation therapy. Major advantages of DOACS include fewer drug interactions and that they do not need periodic monitoring. Several patients who were not on anticoagulation before due to older age, polypharmacy/drug interaction concerns, and logistics of periodic monitoring are now on anticoagulation with DOACs. Despite their many advantages, a challenge while prescribing DOACs is very limited availability of specific reversal agents and lack of understanding or guidance about the treatment strategy in case of major life threatening bleeding or need for urgent surgery. So far only one reversal agent has been approved by the Food and Drug Administration (FDA), idarucizumab for one of the DOACs i.e., dabigatran. Several other reversal agents are under final phases of development such as andexanet alfa and PER977 (ciraparantag) and will help in developing specific strategies for reversal of these agents. In this article, we review current strategies to manage bleeding with DOACs and provide guidance to clinicians of inhibiting LF activity in vitro and in cells, as well as in animal models of anthrax infection.", "neg": "The film tells the story of a psychiatrist, Dr. Cross (Vincent Price), who is treating a young woman, Janet Stewart (Anabel Shaw), who is in a coma-state, brought on when she heard loud arguing, went to her window and saw a man strike his wife with a candlestick and kill her. It also stars Lynn Bari as Dr. Cross's nurse/lover, Elaine Jordan. As Stewart comes out of her shock, she recognizes Dr. Cross as the killer. He then takes her to his sanitarium and at Elaine's urging, gives Janet an overdose of insulin under the pretense of administering insulin shock therapy. He can't bring himself to murder her in cold blood, though, and asks Elaine to get the medicine to save her. Elaine refuses, they argue, and he strangles her. A colleague of Dr. Cross, Dr. Harvey, saves Janet's life and Dr. Cross is taken into custody by a lawyer from the District Attorney's office.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}443{"query": "Reported prevalence of restless legs syndrome (RLS), also known as Willis-Ekbom disease (WED), varies from country to country, and methodologic inconsistencies limit comparison of data. Impact of RLS on quality of life and health has been studied primarily in industrialized countries, particularly Europe and the United States. Many studies have relied exclusively on self-report of symptoms or have assessed only medical populations. Recently, interest has emerged on the impact of WED in rural, underserved populations globally. In a population-based survey conducted in rural Ecuador, we assessed the relationship of psychological distress to WED, evaluated with the Depression Anxiety Stress Scales-21. WED was diagnosed through a 2-phase method in which all residents were screened with the International Restless Legs Syndrome Study Group (IRLSSG) questionnaire and all suspected cases were subsequently confirmed through expert medical examination. WED severity was assessed with the IRLSSG rating scale. Of 665 persons (mean [SD] age, 59.5 [12.6] years; women, 386 [58%]), 76 had depression, 93 had anxiety, and 60 reported stress. Forty persons (6%) had WED, with 15 (38%) having severe disease. In a regression model adjusted for age and sex, the prevalence of depression, anxiety, and stress was about 3 times greater among persons with WED than the general population. Although cross-sectional data cannot establish causation, this study shows the large behavioral health burden associated with WED in an untreated, rural population.", "pos": "Restless legs syndrome/Willis Ekbom disease (RLS/WED) has been recognized as a significant medical disorder since the 17th century. It was studied mostly in the last 50 years in relation to increasing interest in sleep medicine and health-related quality of life. This led to recognition that the disease is not well characterized as restless feelings in the legs. These symptoms are reported in many situations, but the subjective experience of RLS/WED patients differs from that experienced by others. Thus a new name has been introduced that avoids problems of symptom definition of a disease by naming it after those who first characterized it, i.e. 'Willis Ekbom disease'. This article emphasizes the importance of RLS/WED for psychiatry. The disease carries significant increased risk for depression and anxiety disorders. Treatment requires consideration of these co-morbid disorders. RLS/WED can exacerbate or even engender psychiatric disease, so treatment of psychiatric disease should also include consideration of RLS/WED. The need for attention to RLS/WED is particularly significant for depression. Most anti-depressants exacerbate or can even engender RLS/WED. Thus this article seeks to introduce RLS/WED in relation to psychiatric practice. It presents the RLS/WED disease, its overlap with psychiatry and the current treatment options.", "neg": "Increased expression of nerve growth factor in injured or inflamed tissue is associated with increased pain. This proof-of-concept study was designed to investigate the safety and analgesic efficacy of tanezumab, a humanized monoclonal antibody that binds and inhibits nerve growth factor. We randomly assigned 450 patients with osteoarthritis of the knee to receive tanezumab (administered at a dose of 10, 25, 50, 100, or 200 g per kilogram of body weight) or placebo on days 1 and 56. The primary efficacy measures were knee pain while walking and the patient's global assessment of response to therapy. We also assessed pain, stiffness, and physical function using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC); the rate of response using the criteria of the Outcome Measures for Rheumatology Committee and Osteoarthritis Research Society International Standing Committee for Clinical Trials Response Criteria Initiative (OMERACT-OARSI); and safety. When averaged over weeks 1 through 16, the mean reductions from baseline in knee pain while walking ranged from 45 to 62% with various doses of tanezumab, as compared with 22% with placebo (P<0.001). Tanezumab, as compared with placebo, was also associated with significantly greater improvements in the response to therapy as assessed with the use of the patients' global assessment measure (mean increases in score of 29 to 47% with various doses of tanezumab, as compared with 19% with placebo; P0.001). The rate of response according to the OMERACT-OARSI criteria ranged from 74 to 93% with tanezumab treatment, as compared with 44% with placebo (P<0.001). The rates of adverse events were 68% and 55% in the tanezumab and placebo groups, respectively. The most common adverse events among tanezumab-treated patients were headache (9% of the patients), upper respiratory tract infection (7%), and paresthesia (7%). In this proof-of-concept study, treatment with tanezumab was associated with a reduction in joint pain and improvement in function, with mild and moderate adverse events, among patients with moderate-to-severe osteoarthritis of the knee. (Funded by Rinat Neuroscience; ClinicalTrials.gov number, NCT00394563.).", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}444{"query": "Coming off their bye week, the Jets stayed at home for a Week 10 duel with the Jacksonville Jaguars. New York would trail early in the first quarter with running back Maurice Jones-Drew's 33-yard touchdown run. The Jets would respond with kicker Jay Feely getting a 32-yard field goal, followed by rookie quarterback Mark Sanchez completing a 7-yard touchdown pass to wide receiver Jerricho Cotchery. In the second quarter, Jacksonville would take the lead as quarterback David Garrard got an 11-yard touchdown run and completed a 26-yard touchdown pass to wide receiver Mike Sims-Walker. New York would close out the half as Feely made a 37-yard field goal. After a scoreless third quarter, the Jets would regain the lead in the fourth quarter with a 40-yard field goal from Feely and a 1-yard touchdown run from running back Thomas Jones (with a failed 2-point conversion). However, the Jaguars got the last laugh as kicker Josh Scobee booted the game-winning 21-yard field goal.", "pos": "Coming off their win over the Vikings, the Broncos traveled to the O.co Coliseum to face their AFC West division rivals, the Oakland Raiders. Broncos' defensive tackle Sylvester Williams blocked a 38-yard field goal attempt by Raiders' placekicker Sebastian Janikowski late in the first quarter. The Broncos then marched down to as far as the Raiders' 8-yard line, but had to settle for a 25-yard field goal by placekicker Brandon McManus early in the second quarter. The Raiders then took a 7-3 lead, with fullback Marcel Reece receiving a 3-yard touchdown pass from quarterback Derek Carr. The Broncos were attempting to take the lead just before halftime, however, quarterback Peyton Manning was intercepted by Raiders' safety Charles Woodson in the end zone. The Broncos' offense went three-and-out on the initial possession of the second half, and on the Raiders' first play from scrimmage, Broncos' linebacker Von Miller forced a strip sack and fumble recovery of Carr deep in Raiders' territory. The Broncos had to settle for a 20-yard field goal by McManus to pull to within 7-6. Following a Raiders' three-and-out, the Broncos re-claimed the lead, with a 52-yard field goal by McManus. Following another Woodson interception of Manning, the Raiders were attempting to take the lead on the first play of the fourth quarter, however, Janikowski missed wide-left on a 40-yard field goal attempt. Trailing 9-7, the Raiders were once again attempting to take lead, until Broncos' cornerback Chris Harris, Jr. stepped in front of an errant Carr pass and returned an interception 74 yards for a touchdown. With 6:14 remaining in the game, the Raiders were in punt formation with a 4th-and-6 at their own 24-yard line. However, a 5-yard neutral zone penalty on Broncos' safety Omar Bolden gave the Raiders a 4th-and-1, and after a successful fourth-down conversion, the Raiders kept the drive alive. With 2:38 remaining in the game, the Broncos' defense denied a 4th-and-long pass completion from Carr to Reece near midfield. However, the Broncos were unable to earn a game-clinching first down just before the two-minute warning, which forced the Raiders to burn two of their three team timeouts. On the very next play, a defensive pass interference penalty on Broncos' cornerback Bradley Roby while defending a pass from Carr to wide receiver Amari Cooper moved the football to the Broncos' 32-yard line. With only one timeout remaining, the Raiders decided to send Janikowski onto the field for a 50-yard field goal to pull the Raiders to within 16-10 with 1:45 remaining in the game. The Raiders' onside kick attempt was unsuccessful, and were forced to use their last timeout on the Broncos' first play from scrimmage. Running back C. J. Anderson gained only two yards on three running plays. With eight seconds remaining, Cooper received a punt near the goal line, but the Broncos' defensive special teams subdued the Raiders' last desperation play of the game. The Broncos earned their eighth consecutive win over the Raiders, the Broncos' longest winning streak over the Raiders in franchise history, a streak that the Raiders would snap later in the season, during the teams' Week 14 rematch in Denver.", "neg": "This game is well known for an infamous penalty that occurred during the overtime period. The Jets were lining up for a game winning 56-yard field goal in overtime to try and give them the win. Nick folk kicked the ball, but the kick went wide right and the Patriots appeared to be taking over with a chance to win. However, Chris Jones of New England was called for a controversial unsportsmanlike conduct penalty after pushing his teammate into the offensive line. This penalty would later be named \"leaping\". The penalty gave the Jets another chance and made the field goal attempt a 51-yard attempt. This time, Folk drilled the kick, and the Jets would go on to stun the Patriots. With the win, the Jets improved to 4-3.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}445{"query": "Ultrasound is sound that has a wave frequency higher than the human ear can detect. It includes all sound with wave frequencies higher than 20,000 waves per second, or 20,000 hertz (Hz). Although we cant hear ultrasound, it is very useful to humans and some other animals. Uses of ultrasound include echolocation, sonar, and ultrasonography. Animals such as bats and dolphins send out ultrasound waves and use their echoes, or reflected waves, to identify the locations of objects they cannot see. This is called echolocation. Animals use echolocation to find prey and avoid running into objects in the dark. You can see in the Figure 1.1 how a bat uses echolocation to find insect prey. Sonar uses ultrasound in a way that is similar to echolocation. Sonar stands for sound navigation and ranging. It is used to locate underwater objects such as submarines. Thats how the ship pictured in the Figure 1.2 is using it. A sonar device is both a sender and a receiver. It sends out ultrasound waves and detects the waves after they reflect from underwater objects. The distance to underwater objects can be calculated from the known speed of sound in water and the time it takes for the sound waves to travel to the object. The equation for distance traveled when speed and time are known is: Distance = Speed Time Consider the ship and submarine pictured in the Figure 1.2. If an ultrasound wave travels from the ship to the submarine and back again in 2 seconds, what is the distance from the ship to the submarine? The sound wave travels from the ship to the submarine in just 1 second, or half the time it takes to make the round trip. The speed of sound waves through ocean water is 1437 m/s. Therefore, the distance from the ship to the submarine is: Q: Now assume that the sonar device on the ship sends an ultrasound wave to the bottom of the water. If the sound wave is reflected back to the device in 4 seconds, how deep is the water? A: The time it takes the wave to reach the bottom is 2 seconds. So the distance from the ship to the bottom of the water is: Distance = 1437 m/s 2 s = 2874 m Another use of ultrasound is to see inside the human body. This use of ultrasound is called ultrasonography. Harmless ultrasound waves are sent inside the body, and the reflected waves are used to create an image on a screen. This technology is used to examine internal organs and unborn babies without risk to the patient. You can see a doctor using ultrasound in the Figure 1.3.", "pos": "People have been using sound to make music for thousands of years. They have invented many different kinds of musical instruments for this purpose. Despite their diversity, however, musical instruments share certain similarities. All musical instruments create sound by causing matter to vibrate. The vibrations start sound waves moving through the air. Most musical instruments use resonance to amplify the sound waves and make the sounds louder. Resonance occurs when an object vibrates in response to sound waves of a certain frequency. In a musical instrument such as a guitar, the whole instrument and the air inside it may vibrate when a single string is plucked. This causes constructive interference with the sound waves, which increases their amplitude. Most musical instruments have a way of changing the frequency of the sound waves they produce. This changes the pitch of the sounds. There are three basic categories of musical instruments: percussion, wind, and stringed instruments. In Figure Researchers at Lawrence Berkeley National Laboratory are pioneering a new way to recover 100-year-old record- ings. Found on fragile wax cylinders and early lacquer records, the sounds reveal a rich acoustic heritage, including languages long lost. For more information on how to recover recordings, see [Link] MEDIA Click image to the left or use the URL below. URL: Ultrasound has frequencies higher than the human ear can detect (higher than 20,000 hertz). Although we cant hear ultrasound, it is very useful. Uses include echolocation, sonar, and ultrasonography. Animals such as bats, whales, and dolphins send out ultrasound waves and use their echoes, or reflected waves, to identify the locations of objects they cannot see. This is called echolocation. Animals use echolocation to find prey and avoid running into objects in the dark. Figure 20.13 and the animation at the URL below show how a bat uses echolocation to locate insect prey. Sonar uses ultrasound in a way that is similar to echolocation. Sonar stands for sound navigation and ranging. It is used to locate underwater objects such as sunken ships or to determine how deep the water is. A sonar device is usually located on a boat at the surface of the water. The device is both a sender and a receiver (see Figure 20.14). It sends out ultrasound waves and detects reflected waves that bounce off underwater objects or the bottom of the water. If you watch the video at the URL below, you can see how sonar is used on a submarine. The distance to underwater objects or the bottom of the water can be calculated from the known speed of sound in water and the time it takes for the waves to travel to the object. The equation for the calculation is: Distance = Speed Time Assume, for example, that a sonar device on a ship sends an ultrasound wave to the bottom of the ocean. The speed of the sound through ocean water is 1437 m/s, and the wave travels to the bottom and back in 2 seconds. What is the distance from the surface to the bottom of the water? The sound wave travels to the bottom and back in 2 seconds, so it travels from the surface to the bottom in 1 second. Therefore, the distance from the surface to the bottom is: Distance = 1437 m/s 1 s = 1437 m You Try It! Problem: The sonar device on a ship sends an ultrasound wave to the bottom of the water at speed of 1437 m/s. The wave is reflected back to the device in 4 seconds. How deep is the water? Ultrasound can be used to \"see\" inside the human body. This use of ultrasound is called ultrasonography. Harmless ultrasound waves are sent inside the body, and the reflected waves are used to create an image on a screen. This technology is used to examine internal organs and unborn babies without risk to the patient. You can see an ultrasound image in Figure 20.15. You can see an animation showing how ultrasonography works at this URL: In this QUEST web extra, Stanford University astrophysicist Todd Hoeksema explains how solar sound waves are a vital ingredient to the science of helioseismology, in which the interior properties of the sun", "neg": "Do's and Don'ts in Whale Watching The Department of Fisheries and Oceans has developed guidelines for whale watching in Johnstone Strait,where killer whales are found on a daily basis each summer. It is strongly recommended that vessel operators follow these guidelines for all kinds of whales. * Approach whales from the side, not from the front or the back. * Approach no closer than 100 metres, then stop the boat but keep the engine on. * Keep noise levels down-no horns, whistles or racing of engines. * Start your boat only after the whales are more than 100 metres from your vessel. * Leave the area slowly, gradually moving faster when you are more than 300 metres from the whales. * Approach and leave slowly, avoiding sudden changes in speed or direction. * Avoid disturbing groups of resting whales. * Keep at low speeds and remain in the same direction if travelling side by side with whales. * When whales are travelling close to shore, avoid crowding them near the shore or coming between the whales and the shore. * Limit the time spent with any group of whales to less than 30 minutes at a time when within 100 to 200 metres of whales. * If there is more than one vessel at the same observation spot, be sure to avoid any boat position that would result in surrounding the whales. * Work together by communicating with other vessels, and make sure that all operators are aware of the whale watching guidelines.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}446{"query": "After Alaungpaya's death, the new Burmese king Naungdawgyi was embroiled in several rebellions, including that of Gen. Minkhaung Nawrahta, and could not resume the war. The war was inconclusive. For all their work, the Burmese gained little of their original objectives. Siam very much remained a thorn to the stability of Burmese peripheral regions. In the following years, Siam continued to provide support to Mon rebels in the south who raised a major rebellion in 1762 as well as those in Lan Na in the north . The only lasting territorial gain the Burmese achieved was the upper Tenasserim coast, on which they previously had only a nominal claim. Although the Siamese troops no longer openly intruded the border, the Mon rebels continued to operate from the Siamese territory. In 1764, the Mon governor of Tavoy, who was made governor by Alaungpaya only four years earlier, revolted until it was put down in November 1764. Likewise, the instabilities in Lan Na resumed soon after the Burmese army left in February 1764, forcing the army to return again later in the year. The inconclusive nature of the war would lead to the next war in 1765.", "pos": "By 1759, Alaungpaya had reunified all of Burma plus Manipur and Lan Na. However, his hold on Lan Na and Tenasserim coast was still nominal. The Siamese who originally were concerned about the rising power of Restored Hanthawaddy now actively supported the ethnic Mon rebels operating in the upper Tenasserim coast. In December 1759, Alaungpaya and his 40,000-strong armies invaded the Tenasserim coast. They crossed over the Tenasserim Hills, and finally reached Ayutthaya on 11 April 1760. But only five days into the siege, the Burmese king suddenly fell ill and the Burmese withdrew. The king died three weeks later, ending the war. The 1760 war was inconclusive. Although Burma had regained the upper Tenasserim coast to Tavoy, they still had to deal with Siamese supported rebellions in Lan Na and at Tavoy . The warfare resumed in August 1765, when two Burmese armies invaded again in a pincer movement on the Siamese capital. The Burmese armies took Ayutthaya in April 1767 after a 14-months' siege. The Burmese armies sacked the city and committed atrocities that mar the Burmese-Thai relations to the present. The Burmese were forced to withdraw a few months later due to the Chinese invasions of their homeland. Burma however had annexed the lower Tenasserim coast.", "neg": "In 1740, the Mon of Lower Burma revolted against the Toungoo Dynasty and founded the Restored Hanthawaddy Kingdom based in Pegu . Throughout the 1740s, the Hanthawaddy forces were winning against Upper Burma-based Toungoo armies. The Siamese were concerned by another rising power in Burma since a strong Burma historically meant future invasions to Siam. Concerned, the Siamese court readily gave protection to the Burmese governors of Martaban and Tavoy who had fled to Siam. In 1745, they sent a diplomatic mission to Ava to evaluate the political situation there, and were received by the Burmese king Mahadhammaraza Dipadi. They saw an Ava court that was on its last legs. By 1751, Restored Hanthawaddy forces were closing in on Ava. The Siamese concerns about the emergence of another strong dynasty based in Pegu appeared imminent. Perhaps as a precautionary measure, the Siamese decided to move their forward base into the upper coast in 1751. While it remains unclear as to whether the Siamese ever intended to go beyond the coast into mainland Lower Burma, the Siamese action nonetheless rang alarm bells in Pegu. Deeply concerned, the Hanthawaddy leadership withdrew two-thirds of their army back down to Lower Burma immediately after they had toppled the last Toungoo king in April 1752. This redeployment of Hanthawaddy troops proved a critical turning point in Burmese history as it gave nascent Upper Burmese resistance groups much needed breathing room. The Hanthawaddy command left less than 10,000 men to pacify all of Upper Burma. Taking advantage of light Hanthawaddy troops, one resistance group, the Konbaung Dynasty led by Alaungpaya, drove out Hanthawaddy troops from Upper Burma by May 1754. Konbaung armies invaded Lower Burma in 1755, and captured Pegu in 1757, ending the 17-year-old Mon kingdom.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}447{"query": "The Lump of Coal is a Christmas short story written by Lemony Snicket and illustrated by Brett Helquist.", "pos": "The Tale of Johnny Town-Mouse is a children's book written and illustrated by Beatrix Potter and first published by Frederick Warne & Co. in December 1918.", "neg": "Chronicles of Avonlea is a collection of short stories by L. M. Montgomery, related to the Anne of Green Gables series.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}448{"query": "Urgent surgery or life-threatening bleeding requires prompt reversal of the anticoagulant effects of dabigatran. This study assessed the ability of three- and four-factor prothrombin complex concentrate (PCC) and idarucizumab (specific antidote for dabigatran) to reverse the anticoagulant effects of dabigatran in a porcine model of trauma. Twelve animals were given dabigatran etexilate (DE) orally and dabigatran intravenously, before infliction of trauma. Six animals received tranexamic acid plus fibrinogen concentrate 12 minutes post-injury. Six PCCs (each 30 and 60 U/kg) and idarucizumab (30 and 60 mg/kg) were added to blood samples ex vivo. Coagulation was assessed by several coagulation assays. All coagulation parameters were altered after dabigatran infusion (plasma level: 442 138 ng/ml). Both three- and four-factor PCCs mostly or completely reversed the effects of dabigatran on thromboelastometry variables and PT but not on aPTT. Idarucizumab neutralised plasma concentrations of dabigatran, and reversed the effects of the drug on coagulation variables. Thrombin generation showed dose-dependent over-correction following the addition of PCC, implying that elevated levels of thrombin are required to overcome dabigatran-induced coagulopathy. In contrast, treatment with idarucizumab returned thrombin generation to baseline levels. Following trauma, therapy with tranexamic acid plus fibrinogen improved correction of coagulation parameters by PCC, and thromboelastometry parameters by idarucizumab. All investigated PCCs improved dabigatran- and trauma-induced coagulopathy to a similar degree. In conclusion, this study shows that three- and four-factor PCCs are similarly effective for dabigatran reversal. Idarucizumab also reversed the effects of dabigatran and, unlike PCCs, was not associated with over-correction of thrombin generation.", "pos": "To evaluate the role of idarucizumab, a humanized monoclonal antibody fragment, as a specific reversal agent for the anticoagulant activity of dabigatran and to review the pharmacology, pharmacokinetic properties, efficacy, and safety of this agent. A literature search was conducted consisting of a PubMed database using the MeSH term idarucizumab and the key word dabigatran antidote. Studies evaluating the pharmacology, pharmacokinetics, safety, and efficacy of idarucizumab for the reversal of the anticoagulant activity of dabigatran were included. Idarucizumab represents a novel treatment option as it is the only humanized, monoclonal antibody fragment that specifically binds to dabigatran. Studies evaluating reversal of dabigatran-induced anticoagulation have demonstrated immediate, complete, and sustained effects with idarucizumab. Idarucizumab did not overcorrect thrombin generation. Additionally, evaluations have shown that dabigatran can be safely reinitiated 24 hours after the administration of idarucizumab. The United States Food and Drug Administration granted priority review for the biologic license application and accelerated approval for idarucizumab. Idarucizumab represents an encouraging development in the reversal of dabigatran. Its novel mechanism of action, pharmacokinetics, tolerability, and lack of thrombotic events contribute positively to its use in patients who experience bleeding or for those who require emergent surgery or procedures.", "neg": "Heme is critical for a variety of cellular processes, but excess intracellular heme may result in oxidative stress and membrane injury. Feline leukemia virus subgroup C receptor (FLVCR1), a member of the SLC49 family of four paralogous genes, is a cell surface heme exporter, essential for erythropoiesis and systemic iron homeostasis. Disruption of FLVCR1 function blocks development of erythroid progenitors, likely due to heme toxicity. Mutations of SLC49A1 encoding FLVCR1 are noted in patients with a rare neurodegenerative disorder: posterior column ataxia with retinitis pigmentosa. FLVCR2 is highly homologous to FLVCR1 and may function as a cellular heme importer. Mutations of SLC49A2 encoding FLVCR2 are observed in Fowler syndrome, a rare proliferative vascular disorder of the brain. The functions of the remaining members of the SLC49 family, MFSD7 and DIRC2 (encoded by the SLC49A3 and SLC49A4 genes), are unknown, although the latter is implicated in hereditary renal carcinomas. SLC48A1 (heme responsive gene-1, HRG-1), the sole member of the SLC48 family, is associated with the endosome and appears to transport heme from the endosome into the cytosol.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}449{"query": "[[Hrothgar]], king of Danelands, and a group of mounted and helmeted warriors chase a large and burly man, whom they consider a monstrous [[troll]], and his young son across a large open field until father and son find themselves on the edge of deep cliff overlooking a beach and a large sea. The father directs his young son, [[Grendel]], to climb down and hide from the attackers' view. The Danes shoot the father dead with their arrows and his dead body plunges down onto the beach far below. The Danish king walks towards the cliff edge and sees the young Grendel hanging but chooses to spare him.Later, Grendel is on the beach below and finds his father's body. After failing to move the large and heavy corpse, the boy takes a sword and cuts the head off to take it home.Many years later, the severed (and mummified) head is inside a cave where the boy Grendel has grown up to be as large and burly as his father. Grendel bloodies his own forehead with stones to express his vengeful anger towards the Danes and the beginning of his own murderous campaign of revenge.When Hrothgar finds twenty of his warriors killed inside his great hall, the Danish king falls into a depression. [[Beowulf (hero)|Beowulf]], with the permission of [[Hygelac]], king of [[Gotaland|Geatland]], sails to Daneland with thirteen Geats on a mission to slay Grendel for Hrothgar.The arrival of Beowulf and his warriors is welcomed by Hrothgar, but the king's village has fallen into a deep despair and many of the pagan villagers convert to Christianity at the urging of an [[Irish monk]]. While Grendel does go into Hrothgar's village during the night, he flees rather than fight.Beowulf learns more about Grendel from Selma the witch and seer, who tells Beowulf that Grendel will not fight him because Beowulf has committed no wrong against him. A villager, recently baptized and thus now unafraid of death, leads Beowulf and his men to the cliff above Grendel's cave, but without a rope they are afraid to die descending to the cave itself, and turn back without even seeing the cave. When that villager is found broken and dead, Beowulf and his men return with a rope and gain entry to Grendel's secret cave. Grendel being absent, one of Beowulf's vengeful men mutilates the mummified head and shrine of Grendel's slain father.That night, Grendel attacks Beowulf and his men while they sleep in Hrothgar's great hall, killing the Geat who desecrated his father's head and then, revenge satisfied, leaps out from the second story, but is caught in a trap by Beowulf, leaving Grendel hanging by his right arm. Grendel, refusing capture, escapes by hacking off his own arm. Grendel, bleeding severely, manages to reach the same beach where he had once found his father's slain corpse and wades into the water, where he dies, his body claimed by a mysterious webbed hand. Hrothgar admits to Beowulf that he had killed Grendel's father for stealing a fish but had spared the child-troll Grendel out of pity.There is great celebration in the hall of Hrothgar, and the king's mood has been livened up by the defeat of Grendel, whose severed arm is kept by the Danes as a trophy.In revealing more about Grendel's nature, Selma recounts how Grendel had once visited her hut and clumsily raped her and has protected her since that day, troubling Beowulf all the more. Yet that does not stop him from moving forward to kiss Selma, who deftly slaps him for tying her up earlier in the film, which he did in an attempt to get her to lead him to Grendel. Nevertheless, she then pulls his head forward and kisses him, quickly initiating and taking the lead in their lovemaking as she straddles him down on her bed.The Danes are later attacked by [[Grendel's mother]], the Sea Hag. Beowulf finds her lair, where she placed Grendel's dead body along with a pile of treasure, and slays Grendel's mother with", "pos": "A Viking boy called Hiccup (voice: Jay Baruchel) introduces his village of Berk (\"it's been here for seven generations, but every single building is new\"). The village is attacked by dragons, who steal food (mostly sheep) and set things on fire (hence all the new buildings). The villagers grab weapons and try to fight the dragons off. Despite being told by every adult in sight to go indoors, Hiccup hauls out a bolas-shooting cannon he made himself and shoots a dragon out of the night sky. (As assistant to the village blacksmith, Gobber (voice: Craig Ferguson), Hiccup has access to tools and materials and knows how to use them.) The dragon lands in the woods some distance form the village and no one believes that he hit anything, so it's the next day before Hiccup can go looking for it. It turns out to be a rare and deadly Night Fury, but Hiccup can't make himself kill it. Instead he releases it -- whereupon it also refrains from killing Hiccup -- and it flies off through the trees.Hiccup discovers that the dragon (which he eventually calls Toothless because of its retractable teeth) has holed up in a steep-sided valley because it can no longer fly more than a few feet at a time. While sketching the dragon, Hiccup realizes that it's missing a tail fin. He makes a prosthetic tail fin out of leather. The new fin helps, but Toothless can't control it and inadvertently takes Hiccup for a ride, giving him a clear idea of what's needed to help the dragon fly right. In a series of workshop and test flight scenes, Hiccup builds and perfects a saddle, a control mechanism for the tail fin, and a safety harness.Meanwhile, Hiccup's father Stoick (voice: Gerard Butler) has signed him up for dragon training with Gobber, which is very different from the training he's already doing with Toothless: he's going to learn to fight dragons. At first, he's the worst student in the class. Since Hiccup has always been an accident-prone klutz, this comes as no surprise to his classmates Astrid (voice: America Ferrera), Snotlout (voice: Jonah Hill), Fishlegs (voice: Christopher Mintz-Plasse), Ruffnut (voice: Kristen Wiig), and her twin brother Tuffnut (voice: T.J. Miller). (Hiccup's a little sweet on Astrid.) Before long, Hiccup is able to use some things he's learned while working with Toothless to soothe and manage the school's practice dragons. (It turns out dragons are just big kitty-cats: they like to be petted, there's a kind of grass that's like cat-nip to them, and they love fish (but hate eels).) When Stoick returns from a failed search for the fabled nest of the dragons, he's surprised but thrilled to hear that his son is doing brilliantly at dragon training. He gives Hiccup a horned helmet made from one of his dead mother's breastplates. But Hiccup, as usual, is unable to get around his father's expectations and speak frankly, so he can't explain that his success at dragon school is unlikely to lead to the slaying of any dragons.When Hiccup subdues a practice dragon, unintentionally earning the privilege of killing it before the entire village, he's horrified and decides to flee with Toothless. However Astrid, having noticed Hiccup's frequent disappearances and secretive behavior, is suspicious. She follows him to the hidden valley and sees Toothless. Unable to explain his relationship with the dragon, Hiccup takes her flying, and she's captivated. But they get caught up in a flock of dragons returning to their nest carrying food. The dragons fly inside a mountainous island and drop the food into a pit, which turns out to contain a huge, terrifying, and very hungry dragon that eats the smaller ones if they don't bring it enough food. Hiccup and Astrid and shocked to realize that the dragons have been stealing their sheep to keep from being eaten themselves. When they get home,", "neg": "In the 19th century, a Grande Dame (Jeanne Moreau) summons The Brothers Grimm to her palace, where the brothers discuss their interpretation of the Cinderella story and notice a painting displayed in the room. The Grande Dame shows the brothers a glass slipper and tells them the story of Danielle de Barbarac, the true story of Cinderella. In 16th-century France, widower Auguste de Barbarac (Jeroen Krabbe), father of eight-year-old Danielle, marries Rodmilla de Ghent (Anjelica Huston), a wealthy baroness with two young daughters, Marguerite and Jacqueline, but he dies of a heart attack shortly afterwards. Before dying, Auguste's last words are directed to Danielle, which causes the Baroness to envy Danielle and treat her miserably for the next ten years. While Marguerite (Megan Dodds) is hostile and cruel to Danielle, Jacqueline (Melanie Lynskey) is kinder and more respectful to her, though she often stays out of the crossfires to keep the peace. By the time Danielle (Drew Barrymore) is eighteen, the estate has fallen into decline, as the Baroness has no interest in farming and wishes to get back to court as soon as possible. Danielle has been reduced to a servant in her own home, waiting on her stepmother and stepsisters, and clinging to her father's last gift, a copy of Thomas More's Utopia. While collecting apples, Danielle sees a man stealing her father's horse and unseats him with an apple. When she recognizes he is Prince Henry (Dougray Scott), she abases herself. He gives her a bag of gold in exchange for her silence. She decides to use the money to rescue their servant, Maurice (Walter Sparrow), whom the Baroness has sold to pay her debts. Henry's escape from the duties of court is foiled when he encounters a band of gypsies robbing an old man. He learns that the old man is Leonardo da Vinci (Patrick Godfrey), who has been summoned to court. Henry chases a thief and returns the Mona Lisa to da Vinci, then returns with him. Meanwhile, Danielle dresses as a noblewoman and leaves to buy back Maurice, but the guards refuse, saying he is being deported to the Americas. She argues for his release and, when Henry overhears, he orders Maurice's release. Intrigued by Danielle's mysterious identity, and amazed by her eloquence and passionate pleas, he begs for her name. Danielle gives Henry the name of her mother, \"Comtesse Nicole de Lancret\", who died giving birth to Danielle. King Francis (Timothy West) and Queen Marie (Judy Parfitt) tell Henry that he must choose a bride before the upcoming masquerade ball, or he will have to wed the Spanish princess Gabriella. All the noble families receive an invitation and Danielle initially believes she is included. When collecting truffles, she meets Henry by the river in the company of da Vinci. Henry and Danielle engage in a lively debate before Danielle runs off after she notices Jacqueline searching for her. Henry invites her to visit the library of a nearby monastery. On the way home, they are ambushed by the gypsies, who are amused by Danielle's outrage and agree to release her with whatever she can carry. When she picks up Henry and begins to walk away, the gypsies offer them a horse. Henry and Danielle spend the night at the gypsy camp, sharing their first kiss and arranging to meet again. The next morning, Danielle catches the Baroness and Marguerite stealing her mother's dress and slippers for Marguerite to wear to the ball. After Marguerite insults Danielle about her mother's death, she punches Marguerite in the face and chases her around the manor until Marguerite threatens to throw Utopia into the fireplace. Danielle returns her mother's slippers to the Baroness in exchange for the book but Marguerite burns it in the fire anyway in an act of spite. After Danielle is punished by whipping, Jacqueline tends to her wounds and condemns Marguerite for insulting Danielle's deceased mother. When Danielle meets Henry later, she wishes to tell him the truth, but is afraid he will reject her after he confesses his love. During", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}450{"query": "Eugene-Melchior Peligot (24 March 1811, Paris -- 15 April 1890, Paris), also known as Eugene Peligot, was a French chemist who isolated the first sample of uranium metal in 1841.", "pos": "Alphonse Milne-Edwards (Paris, 13 October 1835 -- Paris, 21 April 1900) was a French mammalologist, ornithologist and carcinologist.", "neg": "Radioactivity is the ability of an atom to emit, or give off, charged particles and energy from the nucleus. The charged particles and energy are called by the general term radiation. Only unstable nuclei emit radiation. When they do, they gain or lose protons. Then the atoms become different elements. (Be careful not to confuse this radiation with electromagnetic radiation, which has to do with the light given off by atoms as they absorb and then emit energy.) Radioactivity was discovered in 1896 by a French physicist named Antoine Henri Becquerel. Becquerel was experimenting with uranium, which glows after being exposed to sunlight. Becquerel wanted to see if the glow was caused by rays of energy, like rays of light and X-rays. He placed a bit of uranium on a photographic plate. The plate was similar to film thats used today to take X-rays. You can see an example of an X-ray in Figure 11.1. As Becquerel predicted, the uranium left an image on the photographic plate. This meant that uranium gives off rays after being exposed to sunlight. Becquerel was a good scientist, so he wanted to repeat his experiment to confirm his results. He placed more uranium on another photographic plate. However, the day had turned cloudy, so he tucked the plate and uranium in a drawer to try again another day. He wasnt expecting the uranium to leave an image on the plate without being exposed to sunlight. To his surprise, there was an image on the plate in the drawer the next day. Becquerel had discovered that uranium gives off rays without getting energy from light. He had discovered radioactivity, for which he received a Nobel prize. To learn more about the importance of Becquerels research, go to this URL: [Link] Another scientist, who worked with Becquerel, actually came up with the term \"radioactivity.\" The other scientist was the French chemist Marie Curie. She went on to discover the radioactive elements polonium and radium. She won two Nobel Prizes for her discoveries. You can learn more about Marie Curie at this URL: [Link] Isotopes are atoms of the same element that differ from each other because they have different numbers of neutrons. Many elements have one or more isotopes that are radioactive. Radioactive isotopes are called radioisotopes. An example of a radioisotope is carbon-14. All carbon atoms have 6 protons, and most have 6 neutrons. These carbon atoms are called carbon-12, where 12 is the mass number (6 protons + 6 neutrons). A tiny percentage of carbon atoms have 8 neutrons instead of the usual 6. These atoms are called carbon-14 (6 protons + 8 neutrons). The nuclei of carbon-14 are unstable because they have too many neutrons. To be stable, a small nucleus like carbon, with just 6 protons, must have a 1:1 ratio of protons to neutrons. In other words, it must have the same number of neutrons as protons. In a large nucleus, with many protons, the ratio must be 2:1 or even 3:1 protons to neutrons. In elements with more than 83 protons, all the isotopes are radioactive (see Figure 11.2). The force of repulsion among all those protons overcomes the strong force holding them together. This makes the nuclei unstable and radioactive. Elements with more than 92 protons have such unstable nuclei that these elements do not even exist in nature. They exist only if they are created in a lab. A low level of radiation occurs naturally in the environment. This is called background radiation. It comes from various sources. One source is rocks, which may contain small amounts of radioactive elements such as uranium. Another source is cosmic rays. These are charged particles that arrive on Earth from outer space. Background radiation is generally considered to be safe for living things. A source of radiation that may be more dangerous is radon. Radon is a radioactive gas that forms in rocks underground. It can seep into basements and get trapped inside buildings. Then it may build up and become harmful to people who breathe it. Other sources of radiation are described in the interactive animation at this URL: [Link] You may have seen a sign like", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}451{"query": "Einsteins equation is possibly the best-known equation of all time. Theres reason for that. The equation is incredibly important. It changed how scientists view energy and matter, which are two of the most basic concepts in all of science. The equation shows that energy and matter are two forms of the same thing. This new idea turned science upside down when Einstein introduced it in the early 1900s. Amazingly, the idea has withstood the test of time as more and more evidence has been gathered to support it. You can listen to an explanation of Einsteins equation at URL: [Link] Q: What do the letters in Einsteins equation stand for? A: E stands for energy, m stands for mass, and c stands for the speed of light. The speed of light is 300,000 kilometers (186,000 miles) per second, so c2 is a very big number. Therefore, the amount of energy in even a small mass of matter is tremendous. Suppose, for example, that you have 1 gram of matter. Thats about the mass of a paperclip. Multiplying this mass by c2 would yield enough energy to power 3,600 homes for a year! Einsteins equation helps scientists understand what happens in nuclear reactions and why they produce so much energy. When the nucleus of a radioisotope undergoes fission or fusion in a nuclear reaction, it loses a tiny amount of mass. What happens to the lost mass? It isnt really lost at all. It is converted to energy. How much energy? E = mc2 . The change in mass is tiny, but it results in a great deal of energy. Q: In a nuclear reaction, mass decreases and energy increases. What about the laws of conservation of mass and conservation of energy? Are mass and energy not conserved in nuclear reactions? Do we need to throw out these laws when it comes to nuclear reactions? A: No, the laws still apply. However, its more correct to say that the sum of mass and energy is always conserved in a nuclear reaction. Mass changes to energy, but the total amount of mass and energy combined remains the same.", "pos": "In the late 1600s, Isaac Newton introduced his law of gravity, which identifies gravity as a force of attraction between all objects with mass in the universe. The law also states that the strength of gravity between two objects depends on their mass and distance apart. Newtons law of gravity was accepted for more than two centuries. It can predict the motion of most objects and was even used by NASA to land astronauts on the moon. Its still used for most practical purposes. However, Newtons law doesnt explain why gravity occurs. It only describes how gravity seems to affect objects. There are also some cases in which Newtons law doesnt even describe what happens. Q: Newton expressed his ideas about gravity as a law. A law in science is a description of what always occurs in nature. For example, according to Newtons law, objects on Earth always fall down, not up. What is needed to explain gravity? A: A theory is needed to explain gravity. In science, a theory is a broad explanation that is supported by a great deal of evidence. In the early 1900s, Albert Einstein came up with a theory of gravity that actually explains gravity rather than simply describing its effects. Einstein showed mathematically that gravity is not really a force that of attraction between all objects with mass, as Newton thought. Instead, Einstein showed that gravity is a result of the warping, or curving, of space and time, which made up the same space-time fabric. These ideas about space-time and gravity became known as Einsteins theory of general relativity. Einstein derived his theory using mathematics. However, you can get a good grasp of it with the help of a simple visual analogy. Imagine a bowling ball pressing down on a trampoline. The surface of the trampoline would curve downward instead of being flat. Now imagine placing a lighter ball at the edge of the trampoline. What will happen? It will roll down toward the bowling ball. This apparent attraction to the bowling ball occurs because the trampoline curves downward, not because the two balls are actually attracted to one another by an invisible force called gravity. Einstein theorized that the sun and other very massive bodies affect space and time around them in a way that is similar to the effect of the bowling ball on the trampoline. The more massive a body is, the more it causes space-time to curve. This idea is represented by the Figure 1.1. According to Einstein, objects move toward one another because of the curves in space-time, not because they are pulling on each other with a force of attraction. Einsteins theory is supported by evidence and widely accepted today, although Newtons law is still used for many calculations.", "neg": "Energy travels through space or material. This is obvious when you stand near a fire and feel its warmth or when you pick up the handle of a metal pot even though the handle is not sitting directly on the hot stove. Invisible energy waves can travel through air, glass, and even the vacuum of outer space. These waves have electrical and magnetic properties, so they are called electromagnetic waves. The transfer of energy from one object to another through electromagnetic waves is known as radiation. Different wavelengths of energy create different types of electromagnetic waves (Figure 1.1). The wavelengths humans can see are known as visible light. When viewed together, all of the wavelengths of visible light appear white. But a prism or water droplets can break the white light into different wavelengths so that separate colors appear (Figure 1.2). What objects can you think of that radiate visible light? Two include the Sun and a light bulb. The longest wavelengths of visible light appear red. Infrared wavelengths are longer than visible red. Snakes can see infrared energy. We feel infrared energy as heat. Wavelengths that are shorter than violet are called ultraviolet. Can you think of some objects that appear to radiate visible light, but actually do not? The Moon and the planets do not emit light of their own; they reflect the light of the Sun. Reflection is when light (or another wave) bounces back from a surface. Albedo is a measure of how well a surface reflects light. A surface with high albedo reflects a large percentage of light. A snow field has high albedo. One important fact to remember is that energy cannot be created or destroyed it can only be changed from one form to another. This is such a fundamental fact of nature that it is a law: the law of conservation of energy. In photosynthesis, for example, plants convert solar energy into chemical energy that they can use. They do not create new energy. When energy is transformed, some nearly always becomes heat. Heat transfers between materials easily, from warmer objects to cooler ones. If no more heat is added, eventually all of a material will reach the same temperature.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}452{"query": "The Secret of Red Gate Farm is the sixth volume in the Nancy Drew Mystery Stories series, written under the pseudonym Carolyn Keene, It was first published in 1931.", "pos": "The Intriguers, first published in 1972, was the fourteenth novel in the Matt Helm spy series by Donald Hamilton.", "neg": "Claire Ridgway (born 1971) is a British writer of history books about the Tudor dynasty, with a particular focus on the life of the Boleyn family.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}453{"query": "STS-48 was a Space Shuttle mission that launched on 12 September 1991, from Kennedy Space Center, Florida.", "pos": "USA-88 was launched at 02:55:00 UTC on 3 February 1993, atop a Delta II carrier rocket, flight number D218, flying in the 7925-9.5 configuration.", "neg": "A new canal with a port in Furth, the Rhine-Main-Danube Canal, was completed in 1992, creating a navigable connection from the Rhine delta in Rotterdam to the Danube Delta on the Black Sea.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}454{"query": "Flora Graeca was a publication of the plants of Greece in the late 18th century, resulting from a survey by John Sibthorp and Ferdinand Bauer.", "pos": "The Gruffalo is a children's book by writer and playwright Julia Donaldson, illustrated by Axel Scheffler, that tells the story of a mouse, the protagonist of the book, taking a walk in a European forest.", "neg": "The military aspect of the war began with the Armistice of Mudros. The military operations of the Greco-Turkish war can be roughly divided into three main phases: the first phase, spanning the period from May 1919 to October 1920, encompassed the Greek Landings in Asia Minor and their consolidation along the Aegean Coast. The second phase lasted from October 1920 to August 1921, and was characterised by Greek offensive operations. The third and final phase lasted until August 1922, when the strategic initiative was held by the Turkish Army.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}455{"query": "Fibrillar -synuclein (-Syn) is the principal component of Lewy bodies, which are evident in individuals affected by Parkinson disease (PD). This neuropathologic form of -Syn plays a central role in PD progression as it has been shown to propagate between neurons. Tools that interfere with -Syn assembly or change the physicochemical properties of the fibrils have potential therapeutic properties as they may be sufficient to interfere with and/or halt cell-to-cell transmission and the systematic spread of -Syn assemblies within the central nervous system. Vertebrate molecular chaperones from the constitutive/heat-inducible heat shock protein 70 (Hsc/p70) family have been shown to hinder the assembly of soluble -Syn into fibrils and to bind to the fibrils and very significantly reduce their toxicity. To understand how Hsc70 family members sequester soluble -Syn, we set up experiments to identify the molecular chaperone--Syn surface interfaces. We cross-linked human Hsc70 and its yeast homologue Ssa1p and -Syn using a chemical cross-linker and mapped the Hsc70- and Ssa1p--Syn interface. We show that the client binding domain of Hsc70 and Ssa1p binds two regions within -Syn similar to a tweezer, with the first spanning residues 10-45 and the second spanning residues 97-102. Our findings define what is necessary and sufficient for engineering Hsc70- and Ssa1p-derived polypeptide with minichaperone properties with a potential as therapeutic agents in Parkinson disease through their ability to affect -Syn assembly and/or toxicity.", "pos": "-Synuclein is an abundant presynaptic protein and a primary component of Lewy bodies in Parkinson disease. Although its pathogenic role remains unclear, in healthy nerve terminals -synuclein undergoes a cycle of membrane binding and dissociation. An -synuclein binding assay was used to screen for vesicle proteins involved in -synuclein membrane interactions and showed that antibodies directed to the Ras-related GTPase Rab3a and its chaperone RabGDI abrogated -synuclein membrane binding. Biochemical analyses, including density gradient sedimentation and co-immunoprecipitation, suggested that -synuclein interacts with membrane-associated GTP-bound Rab3a but not to cytosolic GDP-Rab3a. Accumulation of membrane-bound -synuclein was induced by the expression of a GTPase-deficient Rab3a mutant, by a dominant-negative GDP dissociation inhibitor mutant unable to recycle Rab3a off membranes, and by Hsp90 inhibitors, radicicol and geldanamycin, which are known to inhibit Rab3a dissociation from membranes. Thus, all treatments that inhibited Rab3a recycling also increased -synuclein sequestration on intracellular membranes. Our results suggest that membrane-bound GTP-Rab3a stabilizes -synuclein on synaptic vesicles and that the GDP dissociation inhibitorHsp90 complex that controls Rab3a membrane dissociation also regulates -synuclein dissociation during synaptic activity.", "neg": "Disturbance of intracellular trafficking plays a major role in several neurodegenerative disorders including Alzheimer or Parkinson's disease. The Chediak-Higashi syndrome (CHS), a life-threatening autosomal recessive disease with frequent mutations in the LYST gene, and its animal model, the beige mouse, are both characterized by lysosomal defects with accumulation of giant lysosomes. Clinically they manifest as hypopigmentation, abnormal bleeding and increased susceptibility to infection with various degrees of involvement of the nervous system. In the course of a recessive N-ethyl-N-nitrosurea (ENU) mutagenesis screen, we identified the first murine missense mutation in the lysosomal trafficking regulator gene (Lyst(Ing3618)) located at a highly conserved position in the WD40 protein domain. Nearly all described human Lyst alleles lead to protein truncation and fatal childhood CHS. Only four different missense mutations have been reported in patients with adolescent or adult forms of CHS involving the nervous system. Interestingly, the Lyst(Ing3618) model presents with a predominant neurodegenerative phenotype with progressive degeneration and loss of Purkinje cells and lacks severe impairment of the immune system. Therefore, the Lyst(Ing3618 )allele could represent a new model for adult CHS with neurological impairment. It could also provide an important tool to elucidate the role of neuronal lysosomal trafficking in the pathophysiology of neurodegeneration.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}456{"query": "A magnet is an object that attracts certain materials such as iron. Youre probably familiar with common bar magnets, like the one shown in the Figure 1.1. Like all magnets, this bar magnet has north and south magnetic poles. The red end of the magnet is the north pole and the blue end is the south pole. The poles are regions where the magnet is strongest. The poles are called north and south because they always line up with Earths north-south axis if the magnet is allowed to move freely. (Earths axis is the imaginary line around which the planet rotates.) Q: What do you suppose would happen if you cut the bar magnet pictured in the Figure 1.1 along the line between the north and south poles? A: Both halves of the magnet would also have north and south poles. If you cut each of the halves in half, all those pieces would have north and south poles as well. Pieces of a magnet always have both north and south poles no matter how many times you cut the magnet. The force that a magnet exerts on certain materials, including other magnets, is called magnetic force. The force is exerted over a distance and includes forces of attraction and repulsion. North and south poles of two magnets attract each other, while two north poles or two south poles repel each other. A magnet can exert force over a distance because the magnet is surrounded by a magnetic field. In the Figure 1.2, you can see the magnetic field surrounding a bar magnet. Tiny bits of iron, called iron filings, were placed under a sheet of glass. When the magnet was placed on the glass, it attracted the iron filings. The pattern of the iron filings shows the lines of force that make up the magnetic field of the magnet. The concentration of iron filings near the poles indicates that these areas exert the strongest force. You can also see how the magnetic field affects the compasses placed above the magnet. When two magnets are brought close together, their magnetic fields interact. You can see how they interact in the Figure 1.3. The lines of force of north and south poles attract each other whereas those of two north poles repel each other.", "pos": "A magnet is an object that attracts certain materials such as iron. Youre probably familiar with common bar magnets, like the one in Figure 24.2. Like all magnets, this bar magnet has north and south poles and attracts objects such as paper clips that contain iron. All magnets have two magnetic poles. The poles are regions where the magnet is strongest. The poles are called north and south because they always line up with Earths north-south axis if the magnet is allowed to move freely. (Earths axis is the imaginary line around which the planet rotates.) What do you suppose would happen if you cut the bar magnet in Figure 24.2 in half along the line between the north and south poles? Both halves would also have north and south poles. If you cut each of the halves in half, all those pieces would have north and south poles as well. Pieces of a magnet always have both north and south poles no matter how many times you cut the magnet. The force that a magnet exerts on certain materials is called magnetic force. Like electric force, magnetic force is exerted over a distance and includes forces of attraction and repulsion. North and south poles of two magnets attract each other, while two north poles or two south poles repel each other. Like the electric field that surrounds a charged particle, a magnetic field surrounds a magnet. This is the area around the magnet where it exerts magnetic force. Figure 24.3 shows the magnetic field surrounding a bar magnet. Tiny bits of iron, called iron filings, were placed under a sheet of glass. When the magnet was placed on the glass, it attracted the iron filings. The pattern of the iron filings shows the lines of force that make up the magnetic field of the magnet. The concentration of iron filings near the poles indicates that these areas exert the strongest force. To see an animated magnetic field of a bar magnet, go to this URL: [Link] When two magnets are brought close together, their magnetic fields interact. You can see how in Figure 24.4. The drawings show how lines of force of north and south poles attract each other whereas those of two north poles repel each other. The animations at the URL below show how magnetic field lines change as two or more magnets move in relation to each other. You can take an animated quiz to check your understanding of magnetic field interactions at this URL: [Link] Magnetism is the ability of a material to be attracted by a magnet and to act as a magnet. No doubt youve handled refrigerator magnets like the ones in Figure 24.5. You probably know first-hand that they stick to a metal refrigerator but not to surfaces such as wooden doors and glass windows. Wood and glass arent attracted to a magnet, whereas the steel refrigerator is. Obviously, only certain materials respond to magnetic force. Magnetism is due to the movement of electrons within atoms of matter. When electrons spin around the nucleus of an atom, it causes the atom to become a tiny magnet, with north and south poles and a magnetic field. In most materials, the electrons orbiting the nuclei of the atoms are arranged in such a way that the materials have no magnetic properties. Also, in most types of matter, the north and south poles of atoms point in all different directions, so overall the matter is not magnetic. Examples of nonmagnetic materials include wood, glass, plastic, paper, copper, and aluminum. These materials are not attracted to magnets and cannot become magnets. In other materials, electrons fill the orbitals of the atoms that make up the material in a way to allow for each atom to have a tiny magnetic field, giving each atom a tiny north and south pole. There are large areas where the north and south poles of atoms are all lined up in the same direction. These areas are called magnetic domains. Generally, the magnetic domains point in different directions, so the material is still not magnetic. However, the material can be magnetized by placing it in a magnetic field. When this happens, all the magnetic domains become aligned, and the material becomes", "neg": "A solenoid is a coil of wire with electric current flowing through it, giving it a magnetic field (see Figure 25.5). Recall that current flowing through a straight wire produces a weak electromagnetic field that circles around the wire. Current flowing through a coil of wire, in contrast, produces a magnetic field that has north and south poles like a bar magnet. The magnetic field around a coiled wire is also stronger than the magnetic field around a straight wire because each turn of the wire has its own magnetic field. Adding more turns increases the strength of the field, as does increasing the amount of current flowing through the coil. You can see an actual solenoid with a compass showing its magnetic north pole at this URL: . Solenoids are the basis of electromagnets. An electromagnet is a solenoid wrapped around a bar of iron or other ferromagnetic material (see Figure 25.6). The electromagnetic field of the solenoid magnetizes the iron bar by aligning its magnetic domains. The combined magnetic force of the magnetized iron bar and the wire coil makes an electromagnet very strong. In fact, electromagnets are the strongest magnets made. Some of them are strong enough to lift a train. The maglev train described earlier, in the lesson \"Electricity and Magnetism,\" contains permanent magnets. Strong electromagnets in the track repel the train magnets, causing the train to levitate above the track. Like a solenoid, an electromagnet is stronger if there are more turns in the coil or more current is flowing through it. A bigger bar or one made of material that is easier to magnetize also increases an electromagnets strength. You can see how to make a simple electromagnet at this URL: (4:57). MEDIA Click image to the left or use the URL below. URL: Many common electric devices contain electromagnets. Some examples include hair dryers, fans, CD players, telephones, and doorbells. Most electric devices that have moving parts contain electric motors. You can read below how doorbells and electric motors use electromagnets. Figure 25.7 shows a diagram of a simple doorbell. Like most doorbells, it has a button located by the front door. Pressing the button causes two electric contacts to come together and complete an electric circuit. In other words, the button is a switch. The circuit is also connected to a voltage source, an electromagnet, and the clapper of a bell. When current flows through the circuit, the electromagnet turns on, and its magnetic field attracts the clapper. This causes the clapper to hit the bell, making it ring. Because the clapper is part of the circuit, when it moves to strike the bell, it breaks the circuit. Without current flowing through the circuit, the electromagnet turns off. The clapper returns to its original position, which closes the circuit again and turns the electromagnet back on. The electromagnet again attracts the clapper, which hits the bell once more. This sequence of events keeps repeating as long as the button by the front door is being pressed. An electric motor is a device that uses an electromagnet to change electrical energy to kinetic energy. Figure 25.8 shows a simple diagram of an electric motor. The motor contains an electromagnet that is connected to a shaft. When current flows through the motor, the electromagnet turns, causing the shaft to turn as well. The rotating shaft moves other parts of the device. Why does the motors electromagnet turn? Notice that the electromagnet is located between the north and south poles of two permanent magnets. When current flows through the electromagnet, it becomes magnetized, and its poles are repelled by the like poles of the permanent magnets. This causes the electromagnet to turn toward the unlike poles of the permanent magnets. A device called a commutator then changes the direction of the current so the poles of the electromagnet are reversed. The reversed poles are once again repelled by the like poles of the permanent magnets. This causes the electromagnet to continue to turn. These events keep repeating, so the electromagnet rotates continuously. You can make a very simple electric motor with a battery, wire, and magnet following instructions at this URL: .", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}457{"query": "According to Finnish historians, the casualties of the Finnish Defence Forces amounted to 63,204 dead or missing and around 158,000 wounded. Officially, the Soviets captured 2,377 Finnish prisoners of war in the Soviet Union, although Finnish researchers estimated the number to be around 3,500 prisoners. 939 Finnish civilians died in air raids and 190 civilians were killed by Soviet partisans. Germany suffered approximately 84,000 casualties in the Finnish front, 16,400 killed, 60,400 wounded and 6,800 missing. In addition to the original peace terms of restoring the 1940 border, Finland was required to Finnish war reparations to the Soviet Union, conduct War-responsibility trials in Finland, lease Porkkalanniemi to the Soviets as well as ban fascist elements and allow left-wing groups, such as the Communist Party of Finland. A Soviet-led Allied Control Commission was installed to enforce and monitor the peace agreement in Finland. The requirement to disarm or expel any German troops left on Finnish soil by 15 September 1944 eventually escalated into the Lapland War between Finland and Germany and the evacuation of the 200,000-strong 20th Mountain Army to Norway.", "pos": "The Germans initial attack involved 410,000 men; just over 1,400 tanks, tank destroyers, and assault guns; 2,600 artillery pieces; 1,600 anti-tank guns; and over 1,000 combat aircraft, as well as large numbers of other Armoured fighting vehicle. These were reinforced a couple of weeks later, bringing the offensives total strength to around 450,000 troops, and 1,500 tanks and assault guns. Between 63,222 and 98,000 of their men were Killed in action, Missing in action, wounded in action, or prisoner of war. For the Americans, out of a peak of 610,000 troops, 89,000 became casualties out of which some 19,000 were killed. The \"Bulge\" was the largest and bloodiest single battle fought by the United States in World War II and the second bloodiest List of battles with most United States military fatalities.", "neg": "In May 1918, a conservative-monarchist Senate was formed by J. K. Paasikivi, and the Senate asked the German troops to remain in Finland. 3 March 1918 Treaty of Brest-Litovsk and 7 March German-Finnish agreements bound White Finland to the German Empire's sphere of influence. General Mannerheim resigned his post on 25 May after disagreements with the Senate about German hegemony over Finland, and about his planned attack on Petrograd to repulse the Bolsheviks and capture Russian Karelia. The Germans opposed these plans due to their peace treaties with Lenin. The Civil War weakened the Finnish Parliament; it became a Rump Parliament that included only three socialist representatives. On 9 October 1918, under pressure from Germany, the Senate and Parliament elected a German prince, Friedrich Karl, the brother-in-law of German Emperor William II, to become the King of Finland. The German leadership was able to utilise the breakdown of Russia for the geopolitical benefit of the German Empire in Fennoscandia also. The Civil War and the aftermath diminished independence of Finland, compared to the status it had held at the turn of the year 1917-1918. The economic condition of Finland deteriorated drastically from 1918; recovery to pre-conflict levels was achieved only in 1925. The most acute crisis was in food supply, already deficient in 1917, though large-scale starvation had been avoided that year. The Civil War caused marked starvation in southern Finland. Late in 1918, Finnish politician Rudolf Holsti appealed for relief to Herbert Hoover, the American chairman of the Committee for Relief in Belgium. Hoover arranged for the delivery of food shipments and persuaded the Allies to relax their blockade of the Baltic Sea, which had obstructed food supplies to Finland, and to allow food into the country.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}458{"query": "Branko Cvetkovic (born 5 March 1984) is a Serbian professional basketball player for Tadamon Zouk of the Lebanese Basketball League.", "pos": "Sven Kaldre (born 31 October 1991) is a professional basketball player who plays as a shooting guard.", "neg": "The Girl and the Oak (Serbo-Croatian: Djevojka i hrast) is a 1955 Yugoslav film directed by Kreso Golik.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}459{"query": "Coptodon bemini is a critically endangered species of fish in the cichlid family.", "pos": "Ravenea rivularis is an endangered species of flowering plant in the Arecaceae family.", "neg": "One of the colors of mink is Aleutian (aa)-a specific gun-metal gray pigmentation of the fur-commonly used in combination with other color loci to generate popular colors such as Violet (aammpp) and Sapphire (aapp). The Aleutian color allele is a manifestation of mink Chediak-Higashi syndrome (CHS), which has been described in humans and several other species. As with forms of CHS in other species, we report that the mink CHS is linked to the lysosomal trafficking regulator ( LYST ) gene. Furthermore, we have identified a base deletion (c.9468delC) in exon 40 of LYST, which causes a frameshift and virtually terminates the LYST product prematurely (p.Leu3156Phefs*37). We investigated the blood parameters of three wild-type mink and three CHS mink. No difference in the platelet number between the two groups was observed, but an accumulation of platelets between the groups appears different when collagen is used as a coagulant. Microscopic analysis of peripheral blood indicates giant inclusions in the neutrophils of the Aleutian mink types. Molecular findings at the LYST locus enable the development of genetic tests for analyzing the color selection in American mink.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}460{"query": "The Fiat L6/40 was a light tank used by the Italian army from 1940 through World War II. It was designed by Fiat-Ansaldo as an export product, and was adopted by the Italian Army when officials learned of the design and expressed interest.", "pos": "The Societa Valdostana Automobili (SVA), was an Italian automobile manufacturer, active in Pont Saint Martin from 1948 to 1951.", "neg": "The Bearded Slave (Italian: Schiavo barbuto) is a marble sculpture by Michelangelo datable to around 1525--1530 and kept in the Galleria dell'Accademia in Florence.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}461{"query": "George Gasper is a mathematician at Northwestern University working on special functions, especially orthogonal polynomials and basic hypergeometric series, who introduced the Askey--", "pos": "Stephen L. Golding (born 1944) is an emeritus professor of psychology at the University of Utah and a forensic psychologist who has written a large amount of articles on the process of determining whether people are competent to stand trial.", "neg": "CADASIL is a cerebrovascular disease caused by mutations in the NOTCH3 gene. Most mutations result in a gain or loss of cysteine residue in one of the 34 epidermal growth factor-like repeats in the extracellular domain of the Notch3 protein, thus sparing the number of cysteine residues. To date, more than 130 different mutations in the NOTCH3 gene have been reported in CADASIL patients, of which 95% are missense point mutations. Many polymorphisms have also been identified in the NOTCH3 coding sequence, some of them leading to amino acid substitutions. The aim of the present study was to analyze the NOTCH3 gene in a large group of patients affected by leukoencephalopathy and to investigate the presence of genetic variants. The molecular analysis revealed several nucleotide alterations. In particular, we identified 20 different mutations, 22 polymorphisms, and 8 genetic variants of unknown pathological significance never reported previously. We hope that this NOTCH3 gene mutational analysis, performed in such a significant number of unrelated and related patients affected by leukoencephalopathy, will help in molecular screening for the NOTCH3 gene, thus contributing to enlargement of the NOTCH3 gene variation database.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}462{"query": "Malaria remains one of the few diseases those continue to scourge human civilization despite the significant advances in disease control strategies over the last century. Malaria is responsible for more than 500 million cases and 1-3 million deaths annually. Approximately 85% of these deaths are among children, mostly in Africa, primarily due to P. falciparum. Whole cell vaccines, irradiated sporozoites and genetically attenuated sporozoites have demonstrated long lasting, sterile protection against plasmodium infection in animal and experimental clinical studies. Atypical membrane protein 1 and merozoite surface protein 1 are the two most extensively studied asexual blood stage vaccine candidates. The most promising candidate vaccine under development is RTS, S combined with AS01 adjuvant. Initial results from phase III trials of this candidate vaccine show 50% reduction of malaria in 5-17 mo aged children during the 12 mo after vaccination. WHO anticipates that the RTS,S/AS01 vaccine will be recommended for the 6-14 week age group for co-administration together with other vaccines as part of routine immunization programs in malaria endemic countries. Malaria vaccine could play an important role in elimination and eventual eradication of malaria.", "pos": "Malaria, which is the result of Plasmodium falciparum infection, is a global health threat that resulted in 655,000 deaths and 216 million clinical cases in 2010 alone. Recent phase 3 trials with malaria vaccine candidate RTS,S/AS01 (RTS,S) in children has demonstrated modest efficacy against clinical and severe malaria. RTS,S targets the pre-erythrocytic phase of the disease and induces high antibody titers against the P. falciparum circumsporozoite protein (CSP) and a moderate CD4(+) T cell response. The individual contribution of these adaptive immune responses to protection from infection remains unknown. Here, we found that prophylactic administration of anti-CSP mAbs derived from an RTS,S-vaccinated recipient fully protected mice with humanized livers from i.v.- and mosquito bitedelivered P. falciparum sporozoite challenge. Titers of anti-CSP that conveyed full protection were within the range observed in human RTS,S vaccine recipients. Increasing anti-CSP titers resulted in a dose-dependent reduction of the liver parasite burden. These data indicate that RTS,S-induced antibodies are protective and provide sterilizing immunity against P. falciparum infection when reaching or exceeding a critical plasma concentration.", "neg": "Malaria is a major human health problem and is responsible for over 2 million deaths per year. It is caused by a number of species of the genus Plasmodium, and Plasmodium falciparum is the causative agent of the most lethal form. Consequently, the development of a vaccine against this parasite is a priority. There are a number of stages of the parasite life cycle that are being targeted for the development of vaccines. Important candidate antigens include proteins on the surface of the asexual merozoite stage, the form that invades the host erythrocyte. The development of methods to manipulate the genome of Plasmodium species has enabled the construction of gain-of-function and loss-of-function mutants and provided new strategies to analyse the role of parasite proteins. This has provided new information on the role of merozoite antigens in erythrocyte invasion and also allows new approaches to address their potential as vaccine candidates.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}463{"query": "One Sky is a jazz album composed by Ryan Cohan, performed by the RC Sextet and released 16 October 2007 on Motema Music.", "pos": "Scelsi Morning is a 2003 album by Marc Ribot released on Tzadik Records.", "neg": "Wars and Rumors of Wars is the third full-length album from the band The Chariot.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}464{"query": "Work is defined differently in physics than in everyday language. In physics, work means the use of force to move an object. The teen who is playing tennis in Figure 16.1 is using force to move her tennis racket, so she is doing work. The teen who is studying isnt moving anything, so she is not doing work. Not all force that is used to move an object does work. For work to be done, the force must be applied in the same direction that the object moves. If a force is applied in a different direction than the object moves, no work is done. Figure 16.2 illustrates this point. The stick person applies an upward force on the box when raising it from the ground to chest height. Work is done because the force is applied in the same direction as the box is moving. However, as the stick person walks from left to right while holding the box at chest height, no more work is done by the persons arms holding the box up. Thats because the force supporting the box acts in a different direction than the box is moving. A small amount of work in the horizontal direction is performed when the person is accelerating during the first step of the walk across the room. But other than that, there is no work, because there is no net force acting on the box horizontally. Work is directly related to both the force applied to an object and the distance the object moves. It can be represented by the equation: Work = Force Distance This equation shows that the greater the force that is used to move an object or the farther the object is moved, the more work that is done. You can see a short video introduction to work as the product of force and distance at this link: . To see the effects of force and distance on work, compare the weight lifters in Figure 16.3. The two weight lifters on the left are lifting the same amount of weight, but the bottom weight lifter is lifting the weight a longer distance. Therefore, this weight lifter is doing more work. The two weight lifters on the bottom right are both lifting the weight the same distance, but the weight lifter on the left is lifting a heavier weight. Therefore, this weight lifter is doing more work. The equation for work given above can be used to calculate the amount of work that is done if force and distance are known. For example, assume that one of the weight lifters in Figure 16.2 lifts a weight of 400 newtons over his head to a height of 2.2 meters off the ground. The amount of work he does is: Work = 400 N 2.2 m = 880 N m Notice that the unit for work is the newton meter. This is the SI unit for work, also called the joule (J). One joule equals the amount of work that is done when 1 newton of force moves an object over a distance of 1 meter. Problem Solving Problem: Todd pushed a 500 N box 4 meters across the floor. How much work did he do? Solution: Use the equation Work = Force Distance. Work = 500 N 4 m = 2000 N m, or 2000 J You Try It! Problem: Lara lifted a 100 N box 1.5 meters above the floor. How much work did she do? Did you ever rake leaves, like the woman in Figure 16.4? It can take a long time to do all that work. But if you use an electric leaf blower, like the man in the figure, the job gets done much sooner. Both the leaf blower and the rake do the work of removing leaves from the yard, but the leaf blower has more power. Thats why it can do the same amount of work in less time. Power is a measure of the amount of work that can be done in a given amount of time. Power can be represented by the equation: Power = Work Time In this equation, work is measured in joules and time is measured in seconds, so power is expressed in joules per second (J/", "pos": "Work is defined differently in physics than in everyday language. In physics, work means the use of force to move an object. The teens who are playing basketball in the picture above are using force to move their bodies and the basketball, so they are doing work. The teen who is studying isnt moving anything, so she isnt doing work. Not all force that is used to move an object does work. For work to be done, the force must be applied in the same direction that the object moves. If a force is applied in a different direction than the object moves, no work is done. The Figure 1.1 illustrates this point. Q: If the box the man is carrying is very heavy, does he do any work as he walks across the room with it? A: Regardless of the weight of the box, the man does no work on it as he holds it while walking across the room. However, he does more work when he first lifts a heavier box to chest height. Work is directly related to both the force applied to an object and the distance the object moves. It can be represented by the equation: Work = Force Distance This equation shows that the greater the force that is used to move an object or the farther the object is moved, the more work that is done. To see the effects of force and distance on work, compare the weight lifters in the Figure 1.2. The two weight lifters on the left are lifting the same amount of weight, but the one on the bottom is lifting the weight a greater distance. Therefore, this weight lifter is doing more work. The two weight lifters on the bottom right are both lifting the weight the same distance, but the weight lifter on the left is lifting a heavier weight, so she is doing more work.", "neg": "Young people frequently say that they want to exercise, but they just can't find the time. The solution just might be in-office interval training. Recent studies show that very short but intense exercise rapidly builds and maintains fitness and health, even when the workout is only a few minutes long. Work the stairs You can complete an excellent, effective -- and very brief -- workout in an office stairwell, says Martin Gibala, a professor of kinesiology at McMaster University in Canada and an expert on interval training. For a study that he and his colleagues presented earlier this year, they asked 12 out-of-shape women in their 20s to warm up for two minutes by slowly walking up and down stairs in a campus office building. They completed three of these abbreviated stair workouts per week for six weeks. By the end, their aerobic fitness had improved substantially, the researchers reported, by about as much as if they had been running or cycling each week for hours. Fidget your way to fitness. Parents and teachers may once have urged you to sit still, but wiggling, tapping your toes, standing briefly, and otherwise fidgeting as much as possible at your desk is in fact good for your body. In one recent study, college students showed healthier blood flow in their lower legs if they fidgeted than if they did not. Even better, a 2008 study found that among office workers, those who frequently fidgeted burned as many as 300 calories more each day than those who resolutely stayed still.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}465{"query": "The film opens with narration over a silhouette of Hill House at night. The narrator, Dr. John Markway (Richard Johnson) tells us, \"An evil old house, the kind some people call haunted is like an undiscovered country waiting to be explored. Hill House had stood for 90 years and might stand for 90 more. Silence lay steadily against the wood and stone of Hill House. Whatever walked there walked alone.\" Title and credits follow, then narration continues, \"Scandal, murder, insanity, suicide: The history of Hill House was ideal. It had everything I wanted...\" The house was built in New England by a man named Hugh Crain for his wife and young daughter. A horse and carriage accident took the life of the first Mrs. Crain (an uncredited Pamela Buckley) before she even saw the house. Hugh Crain (an uncredited Howard Lang) and young daughter, Abigail (an uncredited Janet Mansell) said a few words over the body, but Hugh was left an embittered man. Crain married again, and the second Mrs. Crain (an uncredited Freda Knorr) also died, falling down the main staircase. Hugh Crain left Abigail with a nurse (an uncredited Susan Richards) and went to England where he died in a drowning accident. Abigail kept the same nursery room her entire life. By the time she was eighty (an uncredited Amy Dalby) she was a bedridden invalid. Her nurse-companion (an uncredited Rosemary Dorken) was a local girl and, it is with this young companion the evil reputation of Hill House really begins. The old lady died while calling for help. The companion was trysting on the verandah with a farm hand. The companion inherited Hill House and occupied it for many years, but eventually hanged herself. The house then passed to a distant relative, named Mrs. Sanderson (Fay Compton).Markway visits Mrs. Sanderson where he convinces her to let him use the house for psychic research. He explains, \"I shall occupy the house with a group of carefully selected assistants...I must have specially qualified help to take notes and document any evidence of the supernatural I may find.\" Eldridge Harper (Ronald Adam), Mrs. Sanderson's lawyer, voices his concern about publicity seekers and the propriety of having women in the house. Harper suggests to Mrs. Sanderson that her nephew, Luke, joins the doctor at Hill House, as he expects to inherit the property. Mrs. Sanderson asks point blank, \"Exactly what do you and your assistants expect to find at Hill House?\" Markway replies, \"Maybe only a few loose floorboards, and maybe, I only say maybe, the key to another world.\"Dr. Markway, taking a leave of absence from his university professorship, finalizes his list of assistants. Only two end up accepting, Eleanor Lance and Theodora (no last name).Eleanor Lance (Julie Harris) is living with her sister. She is nearly broke and weary after looking after her invalid mother non-stop for eleven years. Mother is now dead, and she fights with her sister over just about everything. She begs to use the car, which is after all, half hers. Her brother-in-law, Bud Fredericks (an uncredited Paul Maxwell) tries to act as mediator between Eleanor and his wife, Carrie (Diane Clare). He is sympathetic to Eleanor's plight, but their daughter, Dora (an uncredited Verina Greenlaw) takes her cues from her mother, and taunts her Aunt Eleanor. On the vacation plan, Bud sides with Eleanor, \"I think you should have a vacation, Nell.\" Carrie objects, but Eleanor is not to be deterred and she shows her family how she reacts when pushed to her breaking point. She is normally quiet and meek, but when pushed is loud and assertive.Nell decides to take the car and confronts the garage attendant (an uncredited Claude Jones) for the keys. She departs Boston along U.S. 50 and Route 238 to Hill House. We hear Nell thinking and she reveals she will never return to live with her sister. In fact, most of what we learn of Eleanor is hearing her thoughts.Eleanor", "pos": "New Orleans, Louisiana, 1927. An enraged posse of men descend on the isolated Seven Doors Hotel deep in the swamps. They grab an artist called Schweik (Antoine Saint John), who is cloistered there. Accusing him of being a warlock, Schweik is dragged down to the cellar where he is savagely beaten with heavy chains, tortured with quicklime acid, and crucified with his wrists nailed to a cellar wall, despite his dire warnings of evil to be unleashed.New Orleans, 1981. Liza Merril (Catriona MacColl) is a young woman who arrives from New York City to claim the hotel as her inheritance. No sooner has architect friend Marin Avery (Michele Mirabella) begins to show her around the property, strange incidents begin to happen. A painter (Anthony Flees) falls off his rig and is horribly injured, coughing up blood and babbling about, \"the eyes, the eyes.\" Dr. John McCabe (David Warbeck) arrives to take the injured man to the hospital, and offers Liza some sympathy. Next, a plumber, named Joe, attempts to repair a major leak in the flooded cellar. However, he is murdered by a presence that emerged from behind a slim-caked wall. The atmosphere at the hotel is further chilled by the creepy-looking servants, Arthur (Giampaolo Saccarola) and Martha (Veronica Lazar), who apparently come with the hotel. Martha discovers Joe's dead body in the cellar, and another much older cadaver lying in a pool of dirty water nearby. It is apparently that of Schweik, the artist.Driving down the 14-mile causeway to New Orleans, Liza encounters a strange blind woman, standing in the middle of the desolate highway. The blind woman introduces herself as Emily (Sarah Keller), and tells Liza that she has been waiting for her, although her eyes are occluded with cataracts. Liza drives Emily over to her opulently furnished house in New Orleans. Liza is warned by Emily to leave the hotel while she still can. Meanwhile at the hospital morgue, Dr. John McCabe is performing the autopsy on Joe the plumber while his assistant Harris (Al Cliver) wants to install an EMG machine to the corpse of Schweik. John laughs it off and leaves for lunch, while Harris remains behind to install the EMG machine. After Harris leaves for a call, the EMG machine begins pulsing with activity. A little later, Joe's wife Mary-Anne (Laura De Marchi) arrives with her daughter Jill (Maria Pia Marsale) to dress up her husband's corpse for the funeral, when she is killed in a horrific way by scalded with acid. Jill is then menaced by the re-animated cadaver of Schweik.Liza meets with John McCabe in a downtown bar to discuss her misgivings and anxieties. He expresses puzzlement when Lisa complains about he ineptitude of her weird servants. John claims to have never heard of them before despite knowing everyone in the area. Then a phone call from the bar arrives from Harris who informs John that Mary-Anne's body was found in the morgue, while Jill was found huddled in a corner frightened and unable to speak. After Joe and Mary-Anne's funeral, Emily appears again to Liza that evening at the hotel. Emily tells Liza about the warlock Schweik, who stayed in Room 36 of the hotel and about the supernatural underworld that the hotel conceals. The hotel was built over one of the Seven Gates of Hell, and Schweik has been the Guardian. Emily is about to reveal more when her hands wander over to a canvas depicting a desolate vision of lost souls in a terrible and arid landscape. Suddenly afraid, Emily says that the painting was painted by Schweik before he died, and she runs out of the hotel parlor into the night. But Liza notices a disquieting fact about her sudden departure: Emily made no footfalls on the bare wooden boards as she ran, and neither did her seeing-eye dog.The next day, Liza ventures nervously into Room 36, a dingy phantasmal of sheet-covered furniture and shafts of dusty light. She finds an ancient book, whose weirdly flesh-like cover bears the single word", "neg": "The movie begins in the year 1967 with a pregnant woman being admitted to a hospital, bleeding from the neck. Paramedics think she was attacked by some type of animal. Doctors perform an emergency C-Section, and her baby (a boy) is born alive just as she dies.Thirty years later a young man named Dennis (Kenny Johnson) is riding in a car with an attractive redhead named Racquel (Traci Lords) heading to an underground nightclub (located, oddly, in a slaughterhouse) somewhere in Los Angeles. After addressing the doorman in Russian, Racquel brings the young man into the club. The man is confused and trying to understand the rules of the club. Some of the regulars indifferently push him aside. Saying he needs a drink, the sprinkler suddenly system activates, raining blood down on everyone inside. It is then that he (and the audience) realizes that everyone in the club is a vampire.Dennis desperately tries to get away and winds up at the feet of a menacing figure in a black-leather trenchcoat. The vampires look on this figure with awe, mumbling the words: \"it's the Daywalker!\" This is our first look at Blade (Wesley Snipes), the vampire killer.Blade pulls out a shotgun and opens fire on the vampires, who instantly burn to ashes when killed. When the gun is knocked out of his hands by Racquel, Blade uses a set of silver stakes to kill Racquel and more vampires, including the disk jockey. Soon all the vamps are either dead or have fled except for one; a heavyset vamp named Quinn (Donal Logue), whom Blade has apparently run into before. Blade pins Quinn to the wall, and then sets him on fire before confronting the last member in the club (the human man from the beginning). Finding no vampire bite marks on Dennis, Blade lets him live and makes his escape as the police arrive.Quinn is extinguished and taken to the local hospital. A morgue technician examines his blood and shows the results to Dr. Karen Jenson (N'Bushe Wright), who finds a number of irregularities, including abnormally developed jaw muscles. As they are discussing the test results, Quinn springs back to life and bites both doctors. Before he can finish Dr. Jenson, Blade shows up and saves her, cutting off one of Quinn's arms.Blade brings Karen to his hideout and asks for help from his mentor, an elderly man named named Whistler (Kris Kristofferson). Whistler injects Dr. Jenson with a solution of garlic essence and silver nitrate and remarks that she has a 50/50 chance of recovering.Meanwhile, a group of vampires are discussing Blade's latest attack on their members. Apparently this club (and to an extent, Quinn) is the property of a vampire named Deacon Frost (Stephen Dorff). Frost wants the vampires to outright rule the humans and use them as a food source while the others (particularly an older vampire named Dragonetti) prefer to maintain a peaceful co-existance. Dragonetti (Udo Kier) in particular does not like Frost because Frost is not a \"pure-blood\" (ie: was not born a vampire, merely became one through the bite of another). Frost is also arrogant and his & the actions of his followers draw unnecessary attention to the vampire underworld.The next morning, Jenson awakens and sees Whistler injecting Blade with some type of serum. She tries to run away but Whistler confronts her and tells her that he and Blade are hunting vampires. Karen of course is skeptical, but Whistler goes on to talk about what they use to hunt- explaining that vampires are severely allergic to silver & garlic while also being vulnerable to sunlight (ultraviolet rays in particular). Whistler fuels up Blade's car and gives him a new UV flashlight to use when hunting that night. Whistler also gives Karen a type of \"vampire mace\" (garlic & silver nitrate in a liquid form).Blade drops Karen off at her apartment and she tries to pack up and get out of town. A police officer, identifying himself as Officer Krieger (Kevin Patrick Walls), arrives and questions her about the events", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}466{"query": "The temperature of the troposphere is highest near the surface of the Earth and decreases with altitude. On average, the temperature gradient of the troposphere is 6.5o C per 1,000 m (3.6o F per 1,000 ft) of altitude. Earths surface is the source of heat for the troposphere. Rock, soil, and water on Earth absorb the Suns light and radiate it back into the atmosphere as heat, so there is more heat near the surface. The temperature is also higher near the surface because gravity pulls in more gases. The greater density of gases causes the temperature to rise. Notice that in the troposphere warmer air is beneath cooler air. This condition is unstable since warm air is less dense than cool air. The warm air near the surface rises and cool air higher in the troposphere sinks, so air in the troposphere does a lot of mixing. This mixing causes the temperature gradient to vary with time and place. The rising and sinking of air in the troposphere means that all of the planets weather takes place in the troposphere. Sometimes there is a temperature inversion, in which air temperature in the troposphere increases with altitude and warm air sits over cold air. Inversions are very stable and may last for several days or even weeks. Inversions form: Over land at night or in winter when the ground is cold. The cold ground cools the air that sits above it, making this low layer of air denser than the air above it. Near the coast, where cold seawater cools the air above it. When that denser air moves inland, it slides beneath the warmer air over the land. Since temperature inversions are stable, they often trap pollutants and produce unhealthy air conditions in cities (Figure 1.1). Smoke makes a temperature inversion visible. The smoke is trapped in cold dense air that lies beneath a cap of warmer air. At the top of the troposphere is a thin layer in which the temperature does not change with height. This means that the cooler, denser air of the troposphere is trapped beneath the warmer, less dense air of the stratosphere. Air from the troposphere and stratosphere rarely mix. Click image to the left or use the URL below. URL:", "pos": "Air temperature changes as altitude increases. In some layers of the atmosphere, the temperature decreases. In other layers, it increases. You can see this in Figure 15.12. Refer to this figure as you read about the layers below. The troposphere is the lowest layer of the atmosphere. In it, temperature decreases with altitude. The troposphere gets some of its heat directly from the Sun. Most, however, comes from Earths surface. The surface is heated by the Sun and some of that heat radiates back into the air. This makes the temperature higher near the surface than at higher altitudes. Look at the troposphere in Figure 15.12. This is the shortest layer of the atmosphere. It rises to only about 12 kilometers (7 miles) above the surface. Even so, this layer holds 75 percent of all the gas molecules in the atmosphere. Thats because the air is densest in this layer. Air in the troposphere is warmer closer to Earths surface. Warm air is less dense than cool air, so it rises higher in the troposphere. This starts a convection cell. Convection mixes the air in the troposphere. Rising air is also a main cause of weather. All of Earths weather takes place in the troposphere. Sometimes air doesnt mix in the troposphere. This happens when air is cooler close to the ground than it is above. The cool air is dense, so it stays near the ground. This is called a temperature inversion. An inversion can trap air pollution near the surface. Temperature inversions are more common in the winter. Can you explain why? At the top of the troposphere is a thin layer of air called the tropopause. You can see it in Figure 15.12. This layer acts as a barrier. It prevents cool air in the troposphere from mixing with warm air in the stratosphere. The stratosphere is the layer above the troposphere. The layer rises to about 50 kilometers (31 miles) above the surface. Air temperature in the stratosphere layer increases with altitude. Why? The stratosphere gets most of its heat from the Sun. Therefore, its warmer closer to the Sun. The air at the bottom of the stratosphere is cold. The cold air is dense, so it doesnt rise. As a result, there is little mixing of air in this layer. The stratosphere contains a layer of ozone gas. Ozone consists of three oxygen atoms (O3 ). The ozone layer absorbs high-energy UV radiation. As you can see in Figure 15.14, UV radiation splits the ozone molecule. The split creates an oxygen molecule (O2 ) and an oxygen atom (O). This split releases heat that warms the stratosphere. By absorbing UV radiation, ozone also protects Earths surface. UV radiation would harm living things without the ozone layer. At the top of the stratosphere is a thin layer called the stratopause. It acts as a boundary between the stratosphere and the mesosphere. The mesosphere is the layer above the stratosphere. It rises to about 85 kilometers (53 miles) above the surface. Temperature decreases with altitude in this layer. There are very few gas molecules in the mesosphere. This means that there is little matter to absorb the Suns rays and heat the air. Most of the heat that enters the mesosphere comes from the stratosphere below. Thats why the mesosphere is warmest at the bottom. Did you ever see a meteor shower, like the one in Figure 15.15? Meteors burn as they fall through the mesosphere. The space rocks experience friction with the gas molecules. The friction makes the meteors get very hot. Many meteors burn up completely in the mesosphere. At the top of the mesosphere is the mesopause. Temperatures here are colder than anywhere else in the atmosphere. They are as low as -100 C (-212 F)! Nowhere on Earths surface is that cold. The thermosphere is the layer above the mesosphere. It rises to 600 kilometers (372 miles) above the surface. The International Space Station orbits Earth in this layer as in Figure 15.16. Temperature increases with altitude in the thermosphere. Surprisingly,", "neg": "Many factors influence the climate of a region. The most important factor is latitude because different latitudes receive different amounts of solar radiation. The Equator receives the most solar radiation. Days are equally long year-round and the Sun is just about directly overhead at midday. The polar regions receive the least solar radiation. The night lasts six months during the winter. Even in summer, the Sun never rises very high in the sky. Sunlight filters through a thick wedge of atmosphere, making the sunlight much less intense. The high albedo, because of ice and snow, reflects a good portion of the Suns light. Its easy to see the difference in temperature at different latitudes in the Figure 1.1. But temperature is not completely correlated with latitude. There are many exceptions. For example, notice that the western portion of South America The maximum annual temperature of the Earth, showing a roughly gradual temperature gradient from the low to the high latitudes. has relatively low temperatures due to the Andes Mountains. The Rocky Mountains in the United States also have lower temperatures due to high altitudes. Western Europe is warmer than it should be due to the Gulf Stream. Click image to the left or use the URL below. URL:", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}467{"query": "All electromagnetic waves travel at the same speed through empty space. That speed, called the speed of light, is 300 million meters per second (3.0 108 m/s). Nothing else in the universe is known to travel this fast. If you could move that fast, you would be able to travel around Earth 7.5 times in just 1 second! The sun is about 150 million kilometers (93 million miles) from Earth, but it takes electromagnetic radiation only 8 minutes to reach Earth from the sun. Electromagnetic waves travel more slowly through a medium, and their speed may vary from one medium to another. For example, light travels more slowly through water than it does through air (see Figure 21.4). You can learn more about the speed of light at this URL: [Link] Although all electromagnetic waves travel at the same speed, they may differ in their wavelength and frequency. Wavelength and frequency are defined in the same way for electromagnetic waves as they are for mechanical waves. Both properties are illustrated in Figure 21.5. Wavelength is the distance between corresponding points of adjacent waves. Wavelengths of electromagnetic waves range from many kilometers to a tiny fraction of a millimeter. Frequency is the number of waves that pass a fixed point in a given amount of time. Frequencies of electro- magnetic waves range from thousands to trillions of waves per second. Higher frequency waves have greater energy. The speed of a wave is a product of its wavelength and frequency. Because all electromagnetic waves travel at the same speed through space, a wave with a shorter wavelength must have a higher frequency, and vice versa. This relationship is represented by the equation: Speed = Wavelength Frequency The equation for wave speed can be rewritten as: Frequency = Speed Speed or Wavelength = Wavelength Frequency Therefore, if either wavelength or frequency is known, the missing value can be calculated. Consider an electromag- netic wave that has a wavelength of 3 meters. Its speed, like the speed of all electromagnetic waves, is 3.0 108 meters per second. Its frequency can be found by substituting these values into the frequency equation: Frequency = 3.0 108 m/s = 1.0 108 waves/s, or 1.0 108 hertz (Hz) 3.0 m You Try It! Problem: What is the wavelength of an electromagnetic wave that has a frequency of 3.0 108 hertz? For more practice calculating the frequency and wavelength of electromagnetic waves, go to these URLs:", "pos": "Electromagnetic radiation is energy that travels in waves across space as well as through matter. Most of the electromagnetic radiation on Earth comes from the sun. Like other waves, electromagnetic waves are characterized by certain wavelengths and wave frequencies. Wavelength is the distance between two corresponding points on adjacent waves. Wave frequency is the number of waves that pass a fixed point in a given amount of time. Electromagnetic waves with shorter wavelengths have higher frequencies and more energy. Visible light and infrared light are just a small part of the full range of electromagnetic radiation, which is called the electromagnetic spectrum. You can see the waves of the electromagnetic spectrum in the Figure 1.1. At the top of the diagram, the wavelengths of the waves are given. Also included are objects that are about the same size as the corresponding wavelengths. The frequencies and energy levels of the waves are shown at the bottom of the diagram. Some sources of the waves are also given. On the left side of the electromagnetic spectrum diagram are radio waves and microwaves. Radio waves have the longest wavelengths and lowest frequencies of all electromagnetic waves. They also have the least amount of energy. On the right side of the diagram are X rays and gamma rays. They have the shortest wavelengths and highest frequencies of all electromagnetic waves. They also have the most energy. Between these two extremes are waves that are commonly called light. Light includes infrared light, visible light, and ultraviolet light. The wavelengths, frequencies, and energy levels of light fall in between those of radio waves on the left and X rays and gamma rays on the right. Q: Which type of light has the longest wavelengths? A: Infrared light has the longest wavelengths. Q: What sources of infrared light are shown in the diagram? A: The sources in the diagram are people and light bulbs, but all living things and most other objects give off infrared light.", "neg": "Energy travels through space or material. This is obvious when you stand near a fire and feel its warmth or when you pick up the handle of a metal pot even though the handle is not sitting directly on the hot stove. Invisible energy waves can travel through air, glass, and even the vacuum of outer space. These waves have electrical and magnetic properties, so they are called electromagnetic waves. The transfer of energy from one object to another through electromagnetic waves is known as radiation. Different wavelengths of energy create different types of electromagnetic waves (Figure 1.1). The wavelengths humans can see are known as visible light. When viewed together, all of the wavelengths of visible light appear white. But a prism or water droplets can break the white light into different wavelengths so that separate colors appear (Figure 1.2). What objects can you think of that radiate visible light? Two include the Sun and a light bulb. The longest wavelengths of visible light appear red. Infrared wavelengths are longer than visible red. Snakes can see infrared energy. We feel infrared energy as heat. Wavelengths that are shorter than violet are called ultraviolet. Can you think of some objects that appear to radiate visible light, but actually do not? The Moon and the planets do not emit light of their own; they reflect the light of the Sun. Reflection is when light (or another wave) bounces back from a surface. Albedo is a measure of how well a surface reflects light. A surface with high albedo reflects a large percentage of light. A snow field has high albedo. One important fact to remember is that energy cannot be created or destroyed it can only be changed from one form to another. This is such a fundamental fact of nature that it is a law: the law of conservation of energy. In photosynthesis, for example, plants convert solar energy into chemical energy that they can use. They do not create new energy. When energy is transformed, some nearly always becomes heat. Heat transfers between materials easily, from warmer objects to cooler ones. If no more heat is added, eventually all of a material will reach the same temperature.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}468{"query": "Marino finished the game with 29 out of 50 pass completions for 318 yards, 1 touchdown, and 2 interceptions. Clayton was the top receiver of the game, with 6 receptions for 92 yards. Walker returned 4 kickoffs for 93 yards and gained 15 yards on 2 punt returns. Nathan was the Dolphins leading rusher with 18 yards, while also catching 10 passes for 83 yards. Craig had 58 rushing yards, 77 receiving yards, and 3 touchdowns. He was the first player ever to score 3 touchdowns in a Super Bowl, and his 2 touchdown catches also tied a Super Bowl record. Tyler led San Francisco in rushing with 65 yards, and also caught 4 passes for 70 yards. Clark caught 6 passes for 77 yards. Board recorded 2 sacks. McLemore recorded 51 punt return yards, the second most in Super Bowl history. Sports Illustrated called 49ers defensive tackle Gary Johnson (American football) the Super Bowls \"unofficial defensive MVP\" after he recorded one sack, flushed Marino out of the passing pocket numerous times, and had four unassisted tackles.", "pos": "The Seattle Seahawks kicked off their 2013 campaign with a hard-fought, ugly win over the Carolina Panthers, 12-7. This game marked Russell Wilson's first 300-yard passing game, and Cam Newton's worst career performance, posting 125 yards through the air, a career low. The first quarter ended equal for both teams, as both sides exchanged a couple of punts. Seattle took their third drive of the game in the second quarter, and drove into the red zone, capping it with a Steven Hauschka 27-yard field goal. Carolina responded immediately, and taking advantage of a couple of Seattle penalties, and some big runs by DeAngelo Williams, with Cam Newton hitting Steve Smith for a 3-yard TD. Seattle responded with a drive to around the Carolina 27 yard line, but Charles Godfrey sacked Russell Wilson and stripped the football, which Carolina recovered. So the first half ended 7-3, Carolina. The second half began with a defensive battle between both sides. Seattle then broke the deadlock with a Steven Hauschka 40-yard field goal, on a drive that lasted over 4 minutes, cutting the lead to 7-6. After forcing Carolina to punt midway through the fourth quarter, Seattle's offense produced its finest drive of the day. A couple of Russell Wilson passes, followed by a Robert Turbin 15-yard scamper, set up Seattle at the Panthers' 43 yard line. Russell Wilson overthrew receiver Stephen Williams on first down, but on second down and 10, by using exactly the same play, Wilson connected with second-year man Jermaine Kearse for a 43-yard score, with 10 minutes left to play. They failed the two-point conversion however, so Seattle had a 12-7 lead. Carolina responded by using DeAngelo Williams on some big runs. Inside the Seattle 35 yard line, Williams took off for a 24-yard scamper, and looked like he was going to score, however at the last possible moment, Earl Thomas forced Williams to fumble inside the 10 yard line.", "neg": "This game is well known for an infamous penalty that occurred during the overtime period. The Jets were lining up for a game winning 56-yard field goal in overtime to try and give them the win. Nick folk kicked the ball, but the kick went wide right and the Patriots appeared to be taking over with a chance to win. However, Chris Jones of New England was called for a controversial unsportsmanlike conduct penalty after pushing his teammate into the offensive line. This penalty would later be named \"leaping\". The penalty gave the Jets another chance and made the field goal attempt a 51-yard attempt. This time, Folk drilled the kick, and the Jets would go on to stun the Patriots. With the win, the Jets improved to 4-3.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}469{"query": "Formed on 24 February 1910, Malmo FF is affiliated with Skanes Fotbollforbund and the team play their home games at the Swedbank Stadion.", "pos": "Associacao Desportiva Bahia de Feira play their home games at Estadio Municipal Alberto Oliveira, nicknamed Estadio Joia da Princesa.", "neg": "Only a Mother (Swedish: Bara en mor) is a 1949 Swedish drama film directed by Alf Sjoberg.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}470{"query": "On countless mornings over the past year, I stood with my son, James, in our driveway, watching our neighbor hurry off to kindergarten.My wife and I wanted to give James the best education, but that meant we'd have to change our jobs and spend less time with our kid.I asked myself, \"Would this trade-off be worth it?\" When I look at the research on child development, I think it might not.Where our kids go to school might matter less than most American parents think. Social scientists have long tried to determine why some children grow up to be successful.In a 2001 study, Greg Duncan, a professor of education at the University of California, measured the influence that the people in a child's life have on how well the child does in school.Duncan and his team found almost no relationship between how students did on the test and whom they sat beside in class, whom they hung out with after school and who lived in their block.The only meaningful link they found was between siblings and twins in particular. For a long time, scholars thought that a family's income heavily affected how well kids did in life.But that might not be the case.When Susan Mayer at the University of Chicago looked at the relationship between family income and lifetime achievement, she ran a series of experiments to measure it, finding such outcomes weren't caused by income.She argued that the things that make a difference are relatively inexpensive: the number of books a kid has or how often his family goes to museums. Lareau, another scholar began one of the most in-depth observations of American parenting.He concluded that success is much more related to the amount of time parents spend with their children.He said \"Many parents I interviewed are anxious about their children's futures.But they have exaggerated the sense of the risks involved if they don't give their children 'the best' of everything.\" So at last, we decided to leave things as it were.More time with our kid is the best we can provide.", "pos": "A new report says promising children money to pass exams does not help exam grades. The report says parents could be wasting their money by using cash to get their kids to study more. However, the promise of a trip somewhere nice could encourage students to try harder and do better at school. Researchers from the University of Bristol (in England) and the University of Chicago (in the USA) looked at how promises of cash and tickets to events affected students' studying and learning. Over 10,000 pupils took part in the research throughout the year 2012. There was an improvement in classwork and homework, but this did not result in better test scores. Lead researcher Dr Simon Burgess suggested the research looked at the wrong areas. He said it had not looked at the things that really got students to increase their effort. He added that: \"Clearly, some pupils have a lot of goals and believe that education is a way of getting what they want out of life, but there are kids who think that working hard doesn't make a difference.\" He said these children think exam success is \"all in your genes\" because of their family background. Education expert Dr Kevan Collins said good teachers were better than promises of rewards to get children to study, especially for children from low-income families. He wrote: \"What really makes the difference is how students are taught.\"", "neg": "To Whom It May Concern, My husband Jim and I got married in 1965. For the first ten years of our marriage, I was very happy to stay home and raise our three children. Then about four years ago, our youngest child went to school, and I thought I might go back to work. Jim was very supportive and helped me to make my decision. He started to do all the things I used to do around the house, and said he thought I could be a great success in business. After several weeks of job hunting, I found my present job, which is working for a small public relation firm. At first, my husband was proud of me and would tell his friends, \"My clever little wife can run that company she's working for.\" But, as his joking words were becoming reality, Jim stopped talking to me about my job. I have received several promotions and pay increases, and I am now making more money than he is. I can buy my own clothes and a new car. Because of our combined incomes, Jim can do things that we had always dreamed of doing, but we don't do these things because he is unhappy. We fought about little things, and Jim is very critical of me in front of our friends. For the first time in our marriage, I think there is a possibility that our marriage may come to an end. I love Jim very much, and I don't want him to feel inferior , but I also love my job. I think I can be a good wife and a working woman, but I don't know how. Can you give me some advice? Will I have to choose one or the other or can I keep both my husband and my new career? Please help. Yours, Mary", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}471{"query": "Tokyo is one of those places that you can love and hate at the same time. In Tokyo there are always too many people in the places where I want to be. Of course there are too many cars. The Japanese drive very fast, but in Tokyo they often spend a long time in traffic jams . Tokyo is not different from London, Paris and New York in that. It is different when one wants to walk. At certain times of the day there are a lot of people on foot in London Oxford Street. But the streets near the Ginze in Tokyo always have a lot of people on foot; and sometimes it is really difficult to walk. People are very polite; there are just too many of them. The worst time to be in the street is at 11: 30 at night. That is when the night-clubs are closing and everybody wants to go home. There are 35,000 night-clubs in Tokyo, and you do not often see one that is empty. During the day, most people travel to and from work by train. Tokyo people buy six million train tickets every day. At most stations, trains arrive every two or three minutes, but at certain hours there do not seem to be enough trains. Although they are usually crowded, Japanese trains are very good. They always leave and arrive on time. On a London train you would see everybody reading a newspaper. In Tokyo trains everybody in a seat seems to be asleep, whether his journey is long or short. In Tokyo, I stood outside the station for five minutes. Three fire-engines race past on the way to one of the many fires that Tokyo has every day. Tokyo has so many surprises that none of them can really surprise me now.", "pos": "I travel a lot, and I find out different \"styles\" of directions every time I ask \"How can I get to the post office?\" Foreign tourists are often confused in Japan because most streets there don't have names; in Japan, people use landmarks in their directions instead of street names. For example, the Japanese will say to travelers,\"Go straight down to the corner. Turn left at the big hotel and go past a fruit market. The post office is across from the bus stop. \" In the countryside of the American Midwest, there are not usually many landmarks. There are no mountains, so the land is very flat; in many places there are no towns or buildings within miles. Instead of landmarks, people will tell you directions and distances. In Kansas or Iowa, for example, people will say,\" Go north two miles. Turn east, and then go another mile. \" People in Los Angeles, California, have no idea of distance on the map; they measure distance in time, not miles. \"How far away is the post office?\" you ask. \"Oh,\" they answer,\"it's about five minutes from here. \" You say,\" Yes, but how many miles away is it?\"They don't know. It's true that a person doesn't know the answer to your question sometimes. What happens in such a situation? A New Yorker might say,\" Sorry, I have no idea. \"But in Yucatan, Mexico, no one answers \"I don't know.\" People in Yucatan believe that \"I don't know. \"is impolite. They usually give an answer, often a wrong one. A tourist can get very, very lost in Yucatan !", "neg": "It does not come as a surprise that Dubai has a growing problem with tragic.The local rulers have explored all the conventional ways to get traffic moving again,including higher prices for parking,fuel and insurance.But at a recent conference in Hamburg,Hussain Lootah said that the city may adopt a more strict approach:setting an income level for vehicle ownership. Mr Lootah's approach is unlikely to be copied widely,but mayors of other big cities around the world are starting to think about taking severe actions of their own,including complete car bans in inner cities.But the efforts may not be enough to reduce traffic and pollution.The problems will only get worse:the number of vehicles sold globally each year will grow from around 80 million today to more than 100 million by the end of the decade,according to IHS Automotive.[] There are already a handful of car-free communities around the world.But these are typically small and often tourist destinations that seek to create a throwback in time,such as Sark Island,in the English Channel.The largest ear-free urban area is probably Venice,where it is impossible to build roads and bridges to link the more than 100 small islands the city sits on. Yet pedestrian malls and other car-free zones keep popping up in cities around the world.Some cities are considering ways to limit central city access to\"green\"machines,such as battery-electric vehicles.Hamburg is perhaps the furthest along. Such extreme plans may fly in a city such as Hamburg.But in many other cities the political resistance even to less far-reaching measures is hard to overcome.Michael Bloomberg,New York's former mayor,tried twice to introduce a jam charge for much of Manhattan,but his plans were rejected by state lawmakers.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}472{"query": "British soldier Jody (Forest Whitaker) is lured by Jude while off duty in Ireland an taken captive by Fergus (Stephan Rea), Jude (Miranda Richardson), Maguire (Adrian Dunbar) and others in the IRA. He is held to be exchanged for a IRA prisoner the British are holding. During the three days Jody is held, he and Fergus become friendly as they talk about their lives and Ferguson shows care by removing the canvass sack on his head. Jody tells Fergus about his girlfriend back in London named Dil. Jody says she is his type of woman. Jody tells Fergus he won't shoot him when it's time because it's not in Fergus' nature. He tells him a parable about the scorpion and the frog. The scorpion asks the frog to take him across the river because the scorpion can't swim. The frog says no because you'll sting me. The scorpion says trust me. Half way across, the frog feels a sharp sting and says to the scorpion as they sink, why did you sting me? Now we'll both drown. I couldn't help it, said the scorpion, it's in my nature. Jody has Ferguson take his wallet with Dil's picture and asks him to go to her place of work or local bar and tell her he was thinking of her at the end. Finally, when it becomes time to shoot Jody, Fergus takes him out into the woods, takes off the hood, but can't shoot him. Jody breaks his bonds and runs away from Fergus. Jody runs onto a road and is hit by one and run over by a second British armored carrier. The carrier and assault troops are attacking the house where Jody was being held. Two IRA members are killed in the attack except Fergus, Jude and Macguire. Fergus decides to disappear and go to London and find Dil. He arranges to get to London and begins working as a day laborer. He goes to the place where Dil works as a hair dresser, has his hair cut and then follows her to \"The Metro,\" a corner bar. Col (Jim Broadbent) is the bartender and he begins the discussion between Dil and Fergus, who is now using the name Jimmie. But soon the two of them are talking to one another. Another man comes up to Dil and drags her out and down the street. Fergus follows them as they go to Dil's apartment and he sits outside and watches them embrace in the window shadows in her flat. Fergus goes to the bar a second time and again talks with Dil after she does a number on the stage and her boyfriend come up. The boyfriend grabs Dil and they go outside and down an alley. Fergus follows them and he defends Dil and knocks the other man down and asks Dil what she would like him to do with the boyfriend. They leave him and go back to Dil's flat. Later the boyfriend shows up outside Dil's flat and she throws all his clothes and possessions out the window. Jimmie asks Dil about the man in a number of pictures in her flat. The man is Jody and Dil says he is a soldier and he is different from the others. Jimmie and Dil begin making out and Jimmie begins to run his hand up Dil's skirt, but she stops him and then performs oral sex on him. She says he can't stay over and they arrange a date for the next day. They go for dinner and end up back at Dil's flat and lie down on the bed. Dil goes into the bathroom and changes into a robe. She returns and Jimmie opens the robe discovers that Dil is a male with a penis. Jimmie is repulsed and hits Dil's as he gets up and heads into the bathroom and vomits in the sink. Dil realizes then that Jimmie was unaware she was a male. Jimmie leaves the flat while Dil pleads with him to stay. After thinking about Dil That night, Jimmie realizes he still cares and writes a letter of apology to Dil and puts it in her mail box. Dil shows up at", "pos": "Vince Rommel (Ross Hagen) is a good sidehacker runner. Sidehacking is a way of running motorcycle races with a passenger on the sidecar/sidehack, and Vince is supposed to be one of the best riders.Vince is in love with Rita (Diane McBain), and both like frolicking around. He asks Rita to marry him. Luke (Dick Merrifield) lost yesterday's race. His mechanic (Ivy Ross) fools around with him. J.C. (Michael Pataki) needs to have his bike ready for an exhibition fast. While the mechanic looks into the bike, Paisley (Claire Polan) talks to Rommel. He's a bit sharp towards her. J.C. notices the sidehack on the bike. Rommel explains that the passenger has to lean one way or another depending on the direction of the curve they are going through. Both the mechanic and Rommel feel that Paisley will be trouble. Dick's wife appears to ask for some money and do some shopping.J.C, Paisley, Rita and Rommel watch a race. J.C. finds it interesting. J.C. offers a position to Rommel in the exhibition, as it's very spectacular. He goes in Rommel's bike as passengers, but he falls down several times. It's good fun until Vince crashes onto a fence and sends J.C. flying. Rita looks how much Rommel and Rita a re in love. J.C. is hot-tempered and violent, and he is a cloud in the lunch everybody is enjoying. J.C. doesn't move without an entourage which tries to placate him. Nero (Edward Parrish) is the only one who tries to stand up agains her. When Rommel rejects his offer, he and his men leave the dining room. Paisley can't even remember what attracted her to him in the first place. J.C. punches her because he wants to hear her scream. J.C. that he'll kill anyone who dares to touch her; then, he says he loves her while she keeps on sobbing.Paisley, dressed to the nines, calls on Rommel at the garage some other day. He rejects her and she leaves slamming the door. Paisley cries and feels jealous of Rita and Rommel's relationship. She tears her dress to pretend that she was raped by Vince Rommel. She spills her lies as soon as J.C. comes back to their hotel room and while Rita's about to have sex with Vince. Rita dreams of her life after she's married to Vince while he falls asleep. She tenderly kisses him.J.C. interrupts them, saying \"Time's up, loverboy\". They beat and tie him up. Rita lies tied to a beam in the roof. She is dead. Vince's car has been dismantled. He runs and runs until he finds a phone booth, but he's got no money, so he keeps on running through some regional road. A car doesn't stop, so he has to keep on walking the long road. He goes to Dick and Debbie (Diane Tessier)'s, and they tend to him. Seeing Dick's children fight in a rough way, he remembers how Rita was gang-raped and killed when she was pushed around and her head hit something. Rommel can't even speak about what happened with Dick.J.C. is getting restless in his hotel room, as the police are looking for him. Dick suggests Vince to try and go on with his life. Rommel says that revenge won't change things as they are, because Rita won't be alive again anyway. They play billiards.Nero tells Rommel that there's an upcoming sidehack bike race. He will help Rommel to take his own back.Rommel prepares his revenge. He goes to the Children's Charity Workers, INC. SALVAGE shop and sells his car. Nero hires a fighting instructor. He also hires a painter who tells him that she has gone somewhere else, where there is no pain. Cooch (Michael Graham) tells him that Rommel's preparing his revenge, hiring people who can fight. Paisley tells him to leave the city and forget about it all, but J.C gets frantic. He says he was like a brother to him, and that he used", "neg": "Jonathan Shale (Berenger) is a mercenary and a Vietnam veteran who returns home to Miami after a botched covert operation in Cuba in which three men from his platoon were killed. He surprises his girlfriend, Jane Hetzko (Diane Venora) at her apartment and is warmly welcomed. On the outside, Jane is a schoolteacher at inner-city Columbus High School, an institution with a considerable gang problem. She is particularly disliked by Juan Lacas (Anthony), leader of the KOD (\"Kings of Destruction\") gang. While jogging one morning, Jane is attacked and has her leg broken. Jane and Shale believe this to be related to the KOD, which prompts the latter to go undercover as an Ivy League-educated, government-affiliated substitute teacher for his girlfriend's class. Shale arrives at Columbus High School and is, at first, taken back by the lowly conditions. He is unable to control his class of poorly-educated students on the first day, but decides to use his street-smarts and military tactics to gain the upper hand. Soon enough, he is able to take command of the students by displaying his combat self-defence techniques when students attack him. He is warned not to use such methods by Principal Claude Rolle (Hudson), but gains the respect of his students when he bonds with them over the similarities between his early gang and Vietnam War experiences and their involvement in petty crime and street gangs. During this time, he befriends fellow schoolteacher Darrell Sherman (Plummer) and also crosses paths with Lacas, one of his students. Suspicious of odd conditions within the high school, Shale sets up surveillance cameras throughout the building. He discovers that Lacas orchestrated the attack on Jane. He also discovers that Lacas is secretly working with Rolle to distribute cocaine around Miami for a major narcotics ring. Shale and his team raid a drug deal, using the stolen money to buy music and sports equipment in the form of a \"school donation.\" While Sherman initially denies Shale's discovery, Sherman and a female student inadvertently witness the drugs being loaded into one of the school buses later that day. Sherman tells the student to warn Shale and Hetzko, and sacrifices himself by creating a distraction. Rolle, who at this point is aware of Shale's interference orders a \"car accident\" for Shale, and sends Lacas after Hetzko. With the help of another student, Lacas is killed and Shale saves Hetzko, learning the full story from the female witness. Shale and his team garrison the school grounds to enter combat against the remaining K.O.D. members, a rival mercenary company led by Janus, and Rolle himself. Ultimately, Shale and Joey Six end up as the sole survivors of the battle, walking away from the school grounds discussing future operations as substitute teachers.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}473{"query": "Bone, as well as the lung and liver, is among the sites of predilection for cancer metastasis. The bone stores large amounts of growth factors such as insulin-like growth factors and transforming growth factor-b, and provides fertile soil for metastatic cancer cells by continuously releasing these bone-stored growth factors, which are a consequence of osteoclastic bone resorption. Metastatic cancer cells in turn produce osteoclast-stimulating cytokines such as parathyroid hormone-related protein( PTH-rP), prostaglandin E2.(PGE2), and various interleukins(ILs). These cancer-produced osteoclast-stimulating cytokines bind to their cognitive receptors and promote the expression of ligands for the receptor activators of nuclear factor kB (RANKL)in osteoblasts. RANKL then binds to its receptor RANK, expressed in pre-osteoclasts, stimulates mature osteoclast formation, and subsequently, osteoclastic bone resorption. This vicious cycle between metastatic cancer cells and osteoclasts is critical to the development and progression of bone metastases. In addition, it is likely that metastatic cancer cells are influenced by bone environments(or niche)and acquire additional capacities such as an epithelial-mesenchymal transition(EMT), allowing them to be resistant to chemotherapy or apoptosis, to survive in a dormant state, or to aggressively spread to distant organs including lung and liver. Thus, the bone can serve as transit port. Disrupting this cycle by inhibiting osteoclastic bone resorption, antagonizing bone-derived growth factors, and neutralizing RANKL or PTH-rP, should be a promising therapeutic intervention for bone metastases. Bisphosphonates(BP)are specific inhibitors of osteoclasts, and have been shown to significantly reduce skeletal-related events(SRE)associated with bone metastasis. Denosumab is a neutralizing monoclonal antibody to RANKL and has recently been found to inhibit SRE more effectively than BP. Further understanding of the crosstalk communication between metastatic cancer cells and bone at the molecular level should lead us to design novel, more effective and specific treatments for cancer patients with bone metastases.", "pos": "The skeletal and immune systems have a complex relationship. Both systems are intimately coupled, with osteoclastogenesis and hematopoiesis occurring in the bone marrow. Bone and immune cells also share common hematopoietic precursors. Furthermore, the skeletal and immune systems share various cytokines, receptors, and transcription factors that regulate signal transduction pathways involved in osteoclastogenesis and immune system activation, including the receptor activator of nuclear factor- ligand/receptor activator of nuclear factor-/osteoprotegerin (RANKL-RANK-OPG) pathway. Cancer cells can disrupt both the skeletal and immune systems. Interaction between cancer and bone cells results in a vicious cycle of bone destruction and cancer growth. Bone remodeling generates a growth-factor-rich environment that attracts cancer cells and promotes their proliferation. In turn, cancer cells stimulate osteoclast formation and activity, resulting in additional bone resorption that further stimulates cancer cell growth. Currently available bone-targeted therapies may also modulate the immune system. Bisphosphonates such as zoledronic acid exert stimulating effects on the immune system, resulting in possible anticancer activity against malignant cells. Denosumab, an anti-RANKL monoclonal antibody with proven antiosteoclast activity, may suppress immune responses. This may result in the reported association with an increased risk of neoplasms, as well as serious skin and other infections as reported in some studies, mainly in the postmenopausal setting. When assessing bone-targeted therapies, it is important to consider the shared signaling pathways between bone and the immune system, as well as the clinical risk:benefit ratio.", "neg": "The objective of this study was to analyze the expression levels of multiple components in the mammalian target of rapamycin (mTOR) signaling pathway in radical nephrectomy specimens from patients with metastatic renal-cell carcinoma (RCC) treated with mTOR inhibitors in order to identify factors predicting susceptibility to these agents. This study retrospectively included a total of 48 consecutive patients undergoing radical nephrectomy, who were diagnosed with metastatic RCC and subsequently treated with an mTOR inhibitor (everolimus or temsirolimus) as either first- or second-line systemic therapy. Expression levels of 5 molecular markers involved in the signaling pathway associated with mTOR, including PTEN, phosphorylated (p)-Akt, p-mTOR, p-p70 ribosomal S6 kinase, and p-4E-binding protein 1 (4E-BP1), were measured by immunohistochemical staining of primary RCC specimens. Of several factors examined, bone metastasis, liver metastasis, and the expression level of p-4E-BP1 were shown to have significant impacts on the response to the mTOR inhibitors. Progression-free survival (PFS) was significantly correlated with the expression levels of PTEN and p-4E-BP1 in addition to the presence of bone metastasis on univariate analysis. Of these significant factors, p-4E-BP1 expression and bone metastasis appeared to be independently associated with PFS on multivariate analysis. These findings suggest that it would be useful to consider the expression levels of potential molecular markers in the mTOR signaling pathway, particularly p-4E-BP1, as well as conventional clinical parameters when selecting patients with metastatic RCC who are likely to benefit from treatment with mTOR inhibitors.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}474{"query": "Though Chad Pennington was active and in uniform for the Jets, the team erred on the side of caution due to injured right ankle, instead starting second-year backup Kellen Clemens, who was making his first career start. The Ravens' defense welcomed him rudely on his first drive with an interception by Ed Reed. The Ravens were able to attain good field position consistently throughout the first half, and quarterback Kyle Boller (who himself was starting in place of an injured starting quarterback, Steve McNair), capitalized with a two-yard touchdown to Willis McGahee late in the first quarter. The teams traded field goals to start the second quarter; Jets kicker Mike Nugent hit a 50-yard field goal, followed by Matt Stover hitting a 28-yard attempt for the Ravens. After Stover missed a 46-yard try, the Jets tried to respond with Nugent attempting a 52-yard field goal, but Nugent missed wide left, his first miss in twenty attempts dating back to last season. Boller once again took advantage of the short field provided and hit tight end Todd Heap on a four-yard touchdown with six seconds left in the half to extend the Ravens' lead to 17-3. Heap's catch was initially ruled incomplete, but the call was subjected to a booth review and reversed, as replays showed he was able to touch both feet within the end zone. After a quiet third quarter, Stover hit a 43-yard field goal to start the fourth quarter, and extended Baltimore's lead to seventeen. Baltimore's defense, which ranked as the best in the NFL in 2006, was able to shut down Clemens and the Jets for most of the game, but Clemens was able to rally the team in the fourth quarter. Using a no huddle offense, Clemens drove the team down to the Baltimore three-yard line, before the Jets settled for a 21-yard field goal. On the Jets' next possession, 44 and 24-yard strikes by Clemens to Jerricho Cotchery got the Jets to the Ravens' goal line, where he found tight end Chris Baker for a three-yard touchdown, cutting the Jets' deficit to seven. Though the Jets failed to convert the ensuing onside kick, poor clock management by Boller gave the Jets the ball back with 2:38 left in the game. Clemens immediately found Cotchery on a 50-yard catch-and-run, later followed by a 24-yard pass to Laveranues Coles that brought the Jets' to the Baltimore seven-yard line with just over a minute to go. Clemens passed to Justin McCareins for a potential touchdown, but the pass was dropped by McCareins. A second pass to McCareins in the end zone deflected off him and into the arms of Ravens linebacker Ray Lewis for the game-ending interception. The loss made the Jets 8-20 since 2002 in games not started by Chad Pennington.", "pos": "Hoping to maintain their winning streak, the Steelers flew to LP Field for an AFC Duel with the Titans. The Steelers wasted no time getting the early lead when on the opening kickoff, Mewelde Moore handed the ball off to rookie wide receiver Antonio Brown, who returned it 89yards for a touchdown. Tennessee would cut the lead when Rob Bironas nailed a 21-yard field goal. Throughout the rest of the game, Pittsburgh scored steadily with kicker Jeff Reed, who hit field goals of 36, 34, 25, and 27yards, putting the Steelers up 19-3. The Titans finally scored a touchdown in the fourth quarter with a Kerry Collins 2-yard pass to former Steeler Nate Washington, and successfully converted the 2-point conversion and onside kick necessary to give themselves the chance to tie the game on the final drive. However, Pittsburgh's defense was able to stop Chris Johnson on a reception as the clock ran out, sealing the victory. Starting quarterback Dennis Dixon sprained his left knee during the second quarter and was replaced by Charlie Batch, but the Steelers defense swarmed the Titans, coming up with four sacks and forcing seven turnovers, the most by Tennessee since 2000. The Titans pulled their starting QB, Vince Young, after his third turnover. After replacing Young, Kerry Collins had two turnovers of his own. Pittsburgh also ended Tennessee running back Chris Johnson's 100-yard rushing streak at 12 games. The NFL's rushing champion had a chance to move one game away from the league record of 14 held by Barry Sanders, but he finished with just 16 carries for 34yards. Steelers linebacker James Harrison had three sacks, forced a fumble and recovered another. Safety Troy Polamalu was credited for an interception and an impressive leaping tackle on Kerry Collins during an attempted goal-line stand by the Steelers to win the game and improve to 2-0.", "neg": "This game is well known for an infamous penalty that occurred during the overtime period. The Jets were lining up for a game winning 56-yard field goal in overtime to try and give them the win. Nick folk kicked the ball, but the kick went wide right and the Patriots appeared to be taking over with a chance to win. However, Chris Jones of New England was called for a controversial unsportsmanlike conduct penalty after pushing his teammate into the offensive line. This penalty would later be named \"leaping\". The penalty gave the Jets another chance and made the field goal attempt a 51-yard attempt. This time, Folk drilled the kick, and the Jets would go on to stun the Patriots. With the win, the Jets improved to 4-3.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}475{"query": "Les Abencerages, ou L'etendard de Grenade (English: The Abencerrages, or The Standard of Granada) is an opera in three acts by Luigi Cherubini with a French libretto by Etienne de Jouy, based on the novel Gonzalve de Cordoue by Jean-Pierre Claris de Florian.", "pos": "The Saboteur is a neo-noir open world third person action-adventure video game set during World War II in German-occupied France.", "neg": "The Gruffalo is a children's book by writer and playwright Julia Donaldson, illustrated by Axel Scheffler, that tells the story of a mouse, the protagonist of the book, taking a walk in a European forest.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}476{"query": "Aluminium smelting is the process of extracting aluminium from its oxide, alumina, generally by the Hall-Heroult process.", "pos": "An alloy is a mixture of a metal with one or more other elements. The other elements may be metals, nonmetals, or both. An alloy is formed by melting a metal and dissolving the other elements in it. The molten solution is then allowed to cool and harden. Alloys generally have more useful properties than pure metals. Several examples of alloys are described and pictured below. If you have braces on your teeth, you might even have this alloy in your mouth! Click image to the left or use the URL below. URL: Most metal objects are made of alloys rather than pure metals. Objects made of four different alloys are shown in the Figure 1.1. Brass saxophone: Brass is an alloy of copper and zinc. It is softer than bronze and easier to shape. Its also very shiny. Notice the curved pieces in this shiny brass saxophone. Brass is used for shap- ing many other curved objects, such as doorknobs and plumbing fixtures. Stain- less steel sink: Stainless steel is a type of steel that contains nickel and chromium in addition to carbon and iron. It is shiny, strong, and resistant to rusting. This makes it useful for sinks, eating utensils, and other objects that are exposed to wa- ter. \"Gold\" bracelet: Pure gold is relatively soft, so it is rarely used for jewelry. Most \"gold\" jewelry is actually made of an alloy of gold, copper and silver. Bronze statue: Bronze was the first alloy ever made. The earliest bronze dates back many thou- sands of years. Bronze is a mixture of copper and tin. Both copper and tin are relatively soft metals, but mixed together in bronze they are much harder. Bronze has been used for statues, coins, and other objects. Q: Sterling silver is an alloy that is used to make fine jewelry. What elements do you think sterling silver contains? What properties might sterling silver have that make it more useful than pure silver? A: Most sterling silver is about 93 percent silver and about 7 percent copper. Sterling silver is harder and stronger than pure silver, while retaining the malleability and luster of pure silver.", "neg": "Eugene-Melchior Peligot (24 March 1811, Paris -- 15 April 1890, Paris), also known as Eugene Peligot, was a French chemist who isolated the first sample of uranium metal in 1841.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}477{"query": "Song and Dance Man is a children's picture book written by Karen Ackerman and illustrated by Stephen Gammell.", "pos": "My Friend Rabbit is a children's picture book written and illustrated by Eric Rohmann.", "neg": "Spirit Warrior, known in Japan as Kujaku-Oh ( Kujaku O, lit. Peacock King), is a manga by Makoto Ogino.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}478{"query": "Following his death, Frank S. Monnette was interred at Oakwood Cemetery, Bucyrus, Ohio and his name added to the Monnett Memorial, Monnett Chapel, Bucyrus, Ohio.", "pos": "Franklin MacVeagh died in Chicago, Illinois, on July 6, 1934, at age 96, and was interred in Graceland Cemetery in Chicago, Illinois.", "neg": "Prelude and Fugue in A minor, BWV 543 is a piece of organ music written by Johann Sebastian Bach sometime around his years as court organist to the Duke of Saxe-Weimar (1708--1717).", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}479{"query": "The Musee du Pantheon National Haitien was opened in 1983.", "pos": "The Alexandria Museum of Art (AMoA) of Alexandria, central Louisiana, USA opened its doors in 1977 in the historic Rapides Bank Building (circa 1898).", "neg": "Crouching Woman is a bronze sculpture by Auguste Rodin.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}480{"query": "An electromagnetic wave is a wave that consists of vibrating electric and magnetic fields. A familiar example will help you understand the fields that make up an electromagnetic wave. Think about a common bar magnet. It exerts magnetic force in an area surrounding it, called the magnetic field. You can see the magnetic field of a bar magnet in Figure 21.1. Because of this force field, a magnet can exert force on objects without touching them. They just have to be in its magnetic field. An electric field is similar to a magnetic field (see Figure 21.1). An electric field is an area of electrical force surrounding a charged particle. Like a magnetic field, an electric field can exert force on objects over a distance without actually touching them. An electromagnetic wave begins when an electrically charged particle vibrates. This is illustrated in Figure 21.2. When a charged particle vibrates, it causes the electric field surrounding it to vibrate as well. A vibrating electric field, in turn, creates a vibrating magnetic field (you can learn how this happens in the chapter \"Electromagnetism\"). The two types of vibrating fields combine to create an electromagnetic wave. You can see an animation of an electromagnetic wave at this URL: (1:31). MEDIA Click image to the left or use the URL below. URL: As you can see in Figure 21.2, the electric and magnetic fields that make up an electromagnetic wave occur are at right angles to each other. Both fields are also at right angles to the direction that the wave travels. Therefore, an electromagnetic wave is a transverse wave. Unlike a mechanical transverse wave, which requires a medium, an electromagnetic transverse wave can travel through space without a medium. Waves traveling through a medium lose some energy to the medium. However, when an electromagnetic wave travels through space, no energy is lost, so the wave doesnt get weaker as it travels. However, the energy is \"diluted\" as it spreads out over an ever-larger area as it travels away from the source. This is similar to the way a sound wave spreads out and becomes less intense farther from the sound source. Electromagnetic waves can travel through matter as well as across space. When they strike matter, they interact with it in the same ways that mechanical waves interact with matter. They may reflect (bounce back), refract (bend when traveling through different materials), or diffract (bend around objects). They may also be converted to other forms of energy. Microwaves are a familiar example. They are a type of electromagnetic wave that you can read about later on in this chapter, in the lesson \"The Electromagnetic Spectrum.\" When microwaves strike food in a microwave oven, they are converted to thermal energy, which heats the food. Electromagnetic radiation behaves like waves of energy most of the time, but sometimes it behaves like particles. As evidence accumulated for this dual nature of electromagnetic radiation, the famous physicist Albert Einstein developed a new theory about electromagnetic radiation, called the wave-particle theory. This theory explains how electromagnetic radiation can behave as both a wave and a particle. In brief, when an electron returns to a lower energy level, it is thought to give off a tiny \"packet\" of energy called a photon (see Figure 21.3). The amount of energy in a photon may vary. It depends on the frequency of electromagnetic radiation. The higher the frequency is, the more energy a photon has. The most important source of electromagnetic radiation on Earth is the sun. Electromagnetic waves travel from the sun to Earth across space and provide virtually all the energy that supports life on our planet. Many other sources of electromagnetic waves that people use depend on technology. Radio waves, microwaves, and X rays are examples. We use these electromagnetic waves for communications, cooking, medicine, and many other purposes. Youll learn about all these types of electromagnetic waves in this chapters lesson on \"The Electromagnetic Spectrum.\"", "pos": "Electromagnetic radiation is energy that travels in waves across space as well as through matter. Most of the electromagnetic radiation on Earth comes from the sun. Like other waves, electromagnetic waves are characterized by certain wavelengths and wave frequencies. Wavelength is the distance between two corresponding points on adjacent waves. Wave frequency is the number of waves that pass a fixed point in a given amount of time. Electromagnetic waves with shorter wavelengths have higher frequencies and more energy. Visible light and infrared light are just a small part of the full range of electromagnetic radiation, which is called the electromagnetic spectrum. You can see the waves of the electromagnetic spectrum in the Figure 1.1. At the top of the diagram, the wavelengths of the waves are given. Also included are objects that are about the same size as the corresponding wavelengths. The frequencies and energy levels of the waves are shown at the bottom of the diagram. Some sources of the waves are also given. On the left side of the electromagnetic spectrum diagram are radio waves and microwaves. Radio waves have the longest wavelengths and lowest frequencies of all electromagnetic waves. They also have the least amount of energy. On the right side of the diagram are X rays and gamma rays. They have the shortest wavelengths and highest frequencies of all electromagnetic waves. They also have the most energy. Between these two extremes are waves that are commonly called light. Light includes infrared light, visible light, and ultraviolet light. The wavelengths, frequencies, and energy levels of light fall in between those of radio waves on the left and X rays and gamma rays on the right. Q: Which type of light has the longest wavelengths? A: Infrared light has the longest wavelengths. Q: What sources of infrared light are shown in the diagram? A: The sources in the diagram are people and light bulbs, but all living things and most other objects give off infrared light.", "neg": "Energy travels through space or material. This is obvious when you stand near a fire and feel its warmth or when you pick up the handle of a metal pot even though the handle is not sitting directly on the hot stove. Invisible energy waves can travel through air, glass, and even the vacuum of outer space. These waves have electrical and magnetic properties, so they are called electromagnetic waves. The transfer of energy from one object to another through electromagnetic waves is known as radiation. Different wavelengths of energy create different types of electromagnetic waves (Figure 1.1). The wavelengths humans can see are known as visible light. When viewed together, all of the wavelengths of visible light appear white. But a prism or water droplets can break the white light into different wavelengths so that separate colors appear (Figure 1.2). What objects can you think of that radiate visible light? Two include the Sun and a light bulb. The longest wavelengths of visible light appear red. Infrared wavelengths are longer than visible red. Snakes can see infrared energy. We feel infrared energy as heat. Wavelengths that are shorter than violet are called ultraviolet. Can you think of some objects that appear to radiate visible light, but actually do not? The Moon and the planets do not emit light of their own; they reflect the light of the Sun. Reflection is when light (or another wave) bounces back from a surface. Albedo is a measure of how well a surface reflects light. A surface with high albedo reflects a large percentage of light. A snow field has high albedo. One important fact to remember is that energy cannot be created or destroyed it can only be changed from one form to another. This is such a fundamental fact of nature that it is a law: the law of conservation of energy. In photosynthesis, for example, plants convert solar energy into chemical energy that they can use. They do not create new energy. When energy is transformed, some nearly always becomes heat. Heat transfers between materials easily, from warmer objects to cooler ones. If no more heat is added, eventually all of a material will reach the same temperature.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}481{"query": "Speed is an important aspect of motion. It is a measure of how fast or slow something moves. It depends on how far something travels and how long it takes to travel that far. Speed can be calculated using this general formula: speed = distance time A familiar example is the speed of a car. In the U.S., this is usually expressed in miles per hour (see Figure 12.6). If your family makes a car trip that covers 120 miles and takes 3 hours, then the cars speed is: speed = 120 mi = 40 mi/h 3h The speed of a car may also be expressed in kilometers per hour (km/h). The SI unit for speed is meters per second (m/s). When you travel by car, you usually dont move at a constant speed. Instead you go faster or slower depending on speed limits, traffic, traffic lights, and many other factors. For example, you might travel 65 miles per hour on a highway but only 20 miles per hour on a city street (see Figure 12.7). You might come to a complete stop at traffic lights, slow down as you turn corners, and speed up to pass other cars. The speed of a moving car or other object at a given instant is called its instantaneous speed. It may vary from moment to moment, so it is hard to calculate. Its easier to calculate the average speed of a moving object than the instantaneous speed. The average speed is the total distance traveled divided by the total time it took to travel that distance. To calculate the average speed, you can use the general formula for speed that was given above. Suppose, for example, that you took a 75-mile car trip with your family. Your instantaneous speed would vary throughout the trip. If the trip took a total of 1.5 hours, your average speed for the trip would be: average speed = 75 mi = 50 mi/h 1.5 h You can see a video about instantaneous and average speed and how to calculate them at this URL: MEDIA Click image to the left or use the URL below. URL: You Try It! Problem: Terri rode her bike very slowly to the top of a big hill. Then she coasted back down the hill at a much faster speed. The distance from the bottom to the top of the hill is 3 kilometers. It took Terri 15 minutes to make the round trip. What was her average speed for the entire trip? The motion of an object can be represented by a distance-time graph like the one in Figure 12.8. A distance-time graph shows how the distance from the starting point changes over time. The graph in Figure 12.8 represents a bike trip. The trip began at 7:30 AM (A) and ended at 12:30 PM (F). The rider traveled from the starting point to a destination and then returned to the starting point again. In a distance-time graph, the speed of the object is represented by the slope, or steepness, of the graph line. If the line is straight, like the line between A and B in Figure 12.8, then the speed is constant. The average speed can be calculated from the graph. The change in distance (represented by Dd) divided by the change in time (represented by Dt): speed = Dd Dt For example, the speed between A and B in Figure 12.8 is: speed = Dd 20 km 0 km 20 km = = = 20 km/h Dt 8:30 7:30 h 1h If the graph line is horizontal, as it is between B and C, then the slope and the speed are zero: speed = Dd 20 km 20 km 0 km = = = 0 km/h Dt 9:00 8:30 h 0.5 h You Try It! Problem: In Figure 12.8, calculate the speed of the rider between C and D. If you know the speed of a moving object, you can also calculate the distance it will travel in a given amount of time. To do so, you would use this version of the general speed formula:", "pos": "How fast or slow something moves is its speed. Speed determines how far something travels in a given amount of time. The SI unit for speed is meters per second (m/s). Speed may be constant, but often it varies from moment to moment. Even if speed varies during the course of a trip, its easy to calculate the average speed by using this formula: speed = distance time For example, assume you go on a car trip with your family. The total distance you travel is 120 miles, and it takes 3 hours to travel that far. The average speed for the trip is: 120 mi 3h = 40 mi/h speed = Q: Terri rode her bike very slowly to the top of a big hill. Then she coasted back down the hill at a much faster speed. The distance from the bottom to the top of the hill is 3 kilometers. It took Terri 41 hour to make the round trip. What was her average speed for the entire trip? (Hint: The round-trip distance is 6 km.) A: Terris speed can be calculated as follows: 6 km 0.25 h = 24 km/h speed = When you travel by car, you usually dont move at a constant speed. Instead you go faster or slower depending on speed limits, traffic lights, the number of vehicles on the road, and other factors. For example, you might travel 65 miles per hour on a highway but only 20 miles per hour on a city street (see the pictures in the Figure 1.1.) You might come to a complete stop at traffic lights, slow down as you turn corners, and speed up to pass other cars. Therefore, your speed at any given instant, or your instantaneous speed, may be very different than your speed at other times. Instantaneous speed is much more difficult to calculate than average speed. Cars race by in a blur of motion on an open highway but crawl at a snails pace when they hit city traffic. If you know the average speed of a moving object, you can calculate the distance it will travel in a given period of time or the time it will take to travel a given distance. To calculate distance from speed and time, use this version of the average speed formula given above: distance = speed time For example, if a car travels at an average speed of 60 km/h for 5 hours, then the distance it travels is: distance = 60 km/h 5 h = 300 km To calculate time from speed and distance, use this version of the formula: time = distance speed Q: If you walk 6 km at an average speed of 3 km/h, how much time does it take? A: Use the formula for time as follows: distance speed 6 km = 3 km/h =2h time =", "neg": "Driving In America Keep Right The traffic follows the \"keep right rule\". While driving, drive on the right side of the road. On one-way, multiple lanes road, the right-most lane would be slowest and left-most lane is fastest. Hand Signals Though indicators are used for the purpose of showing which direction you are going, knowing some hand signals is very important and are usually always asked in a driving test. When you want to turn right, you can put your left hand out of the window and point upward. When you want to make a left turn, you can reach your left arm out of the window and point to the left. If you want to slow down or stop, you can just point downward. School Buses Yellow school buses have flashing red lights and stop signs that reach out from the driver's side. The drivers use these warning signals when letting pupils on and off. No matter which side of the road you are traveling on, if you come upon a school bus with its lights flashing and a stop sign used, you must stop. It's the law. Remain stopped until the lights stop flashing or the stop sign is removed. Using the Horn Using horns is not common in America. Actually they are very rarely used. You may use your horn to warn walkers or other drivers of possible trouble or to avoid accidents. Do not use your horn to express anger or complain about other drivers' mistakes or to try to get a slow driver to move faster.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}482{"query": "Restless Legs Syndrome (RLS) or Willis-Ekbom Disease (WED) is highly prevalent, but patients and healthcare providers alike know little about it. Furthermore, controversy persists as to the best way of diagnosing this nosological entity. To verify whether the term used to refer to this disease entity (Restless Legs Syndrome or Willis-Ekbom Disease) affects the prevalence of self-diagnosed RLS/WED in a sample of newly graduated physicians. Newly graduated physicians were asked to self-evaluate for the presence of RLS/WED. Briefly, participants were allocated randomly across two groups. One was asked to self-assess for RLS, while the other was asked to self-assess for WED. The evaluation form given to one group asked 'Do you have Restless Legs Syndrome?' whereas the form given to participants in the other group asked 'Do you have Willis-Ekbom Disease?'. Both forms also contained the four criteria for diagnosing RLS proposed by the International Restless Legs Syndrome Study Group (IRLSSG) and instructions for self-diagnosis according to these criteria. The study sample comprised 1413 newly graduated physicians. Of the 708 participants who were given the form that used the term RLS, 87 (12.28%) diagnosed themselves with the condition. Conversely, of 705 physicians given the form with the term WED, 13 (1.84%) diagnosed themselves with the condition (p<0.0001). A greater proportion of newly graduated physicians diagnosed themselves with RLS/WED when presented with the term Restless Legs Syndrome than when presented with the term Willis-Ekbom Disease. This suggests that the term Restless Legs Syndrome may not be the most appropriate term to denote this nosological entity.", "pos": "Restless legs syndrome (RLS)/Willis-Ekbom disease (WED) is a common disorder, occurring at least twice a week and causing at least moderate distress in 1.5% to 2.7% of the population. It is important for primary care physicians to be familiar with this disorder and its management. Much has changed in its management since our previous algorithm was published in 2004, including the availability of several new drugs. This revised algorithm was written by members of the Medical Advisory Board of the Willis-Ekbom Disease Syndrome Foundation based on scientific evidence and expert opinion. It considers the management of RLS/WED under intermittent RLS/WED, chronic persistent RLS/WED, and refractory RLS/WED. Nonpharmacological approaches, including mental alerting activities, avoiding substances or medications that may exacerbate RLS, and the role of iron supplementation, are outlined. Chronic persistent RLS/WED should be treated with either a nonergot dopamine agonist or a calcium channel -2- ligand. We discuss the available drugs, the factors determining which to use, and their adverse effects. We define refractory RLS/WED and describe management approaches, including combination therapy and the use of high-potency opioids.", "neg": "Increased expression of nerve growth factor in injured or inflamed tissue is associated with increased pain. This proof-of-concept study was designed to investigate the safety and analgesic efficacy of tanezumab, a humanized monoclonal antibody that binds and inhibits nerve growth factor. We randomly assigned 450 patients with osteoarthritis of the knee to receive tanezumab (administered at a dose of 10, 25, 50, 100, or 200 g per kilogram of body weight) or placebo on days 1 and 56. The primary efficacy measures were knee pain while walking and the patient's global assessment of response to therapy. We also assessed pain, stiffness, and physical function using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC); the rate of response using the criteria of the Outcome Measures for Rheumatology Committee and Osteoarthritis Research Society International Standing Committee for Clinical Trials Response Criteria Initiative (OMERACT-OARSI); and safety. When averaged over weeks 1 through 16, the mean reductions from baseline in knee pain while walking ranged from 45 to 62% with various doses of tanezumab, as compared with 22% with placebo (P<0.001). Tanezumab, as compared with placebo, was also associated with significantly greater improvements in the response to therapy as assessed with the use of the patients' global assessment measure (mean increases in score of 29 to 47% with various doses of tanezumab, as compared with 19% with placebo; P0.001). The rate of response according to the OMERACT-OARSI criteria ranged from 74 to 93% with tanezumab treatment, as compared with 44% with placebo (P<0.001). The rates of adverse events were 68% and 55% in the tanezumab and placebo groups, respectively. The most common adverse events among tanezumab-treated patients were headache (9% of the patients), upper respiratory tract infection (7%), and paresthesia (7%). In this proof-of-concept study, treatment with tanezumab was associated with a reduction in joint pain and improvement in function, with mild and moderate adverse events, among patients with moderate-to-severe osteoarthritis of the knee. (Funded by Rinat Neuroscience; ClinicalTrials.gov number, NCT00394563.).", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}483{"query": "Work is defined differently in physics than in everyday language. In physics, work means the use of force to move an object. The teens who are playing basketball in the picture above are using force to move their bodies and the basketball, so they are doing work. The teen who is studying isnt moving anything, so she isnt doing work. Not all force that is used to move an object does work. For work to be done, the force must be applied in the same direction that the object moves. If a force is applied in a different direction than the object moves, no work is done. The Figure 1.1 illustrates this point. Q: If the box the man is carrying is very heavy, does he do any work as he walks across the room with it? A: Regardless of the weight of the box, the man does no work on it as he holds it while walking across the room. However, he does more work when he first lifts a heavier box to chest height. Work is directly related to both the force applied to an object and the distance the object moves. It can be represented by the equation: Work = Force Distance This equation shows that the greater the force that is used to move an object or the farther the object is moved, the more work that is done. To see the effects of force and distance on work, compare the weight lifters in the Figure 1.2. The two weight lifters on the left are lifting the same amount of weight, but the one on the bottom is lifting the weight a greater distance. Therefore, this weight lifter is doing more work. The two weight lifters on the bottom right are both lifting the weight the same distance, but the weight lifter on the left is lifting a heavier weight, so she is doing more work.", "pos": "Work is defined differently in physics than in everyday language. In physics, work means the use of force to move an object. The teen who is playing tennis in Figure 16.1 is using force to move her tennis racket, so she is doing work. The teen who is studying isnt moving anything, so she is not doing work. Not all force that is used to move an object does work. For work to be done, the force must be applied in the same direction that the object moves. If a force is applied in a different direction than the object moves, no work is done. Figure 16.2 illustrates this point. The stick person applies an upward force on the box when raising it from the ground to chest height. Work is done because the force is applied in the same direction as the box is moving. However, as the stick person walks from left to right while holding the box at chest height, no more work is done by the persons arms holding the box up. Thats because the force supporting the box acts in a different direction than the box is moving. A small amount of work in the horizontal direction is performed when the person is accelerating during the first step of the walk across the room. But other than that, there is no work, because there is no net force acting on the box horizontally. Work is directly related to both the force applied to an object and the distance the object moves. It can be represented by the equation: Work = Force Distance This equation shows that the greater the force that is used to move an object or the farther the object is moved, the more work that is done. You can see a short video introduction to work as the product of force and distance at this link: . To see the effects of force and distance on work, compare the weight lifters in Figure 16.3. The two weight lifters on the left are lifting the same amount of weight, but the bottom weight lifter is lifting the weight a longer distance. Therefore, this weight lifter is doing more work. The two weight lifters on the bottom right are both lifting the weight the same distance, but the weight lifter on the left is lifting a heavier weight. Therefore, this weight lifter is doing more work. The equation for work given above can be used to calculate the amount of work that is done if force and distance are known. For example, assume that one of the weight lifters in Figure 16.2 lifts a weight of 400 newtons over his head to a height of 2.2 meters off the ground. The amount of work he does is: Work = 400 N 2.2 m = 880 N m Notice that the unit for work is the newton meter. This is the SI unit for work, also called the joule (J). One joule equals the amount of work that is done when 1 newton of force moves an object over a distance of 1 meter. Problem Solving Problem: Todd pushed a 500 N box 4 meters across the floor. How much work did he do? Solution: Use the equation Work = Force Distance. Work = 500 N 4 m = 2000 N m, or 2000 J You Try It! Problem: Lara lifted a 100 N box 1.5 meters above the floor. How much work did she do? Did you ever rake leaves, like the woman in Figure 16.4? It can take a long time to do all that work. But if you use an electric leaf blower, like the man in the figure, the job gets done much sooner. Both the leaf blower and the rake do the work of removing leaves from the yard, but the leaf blower has more power. Thats why it can do the same amount of work in less time. Power is a measure of the amount of work that can be done in a given amount of time. Power can be represented by the equation: Power = Work Time In this equation, work is measured in joules and time is measured in seconds, so power is expressed in joules per second (J/", "neg": "A mechanical wave is a disturbance in matter that transfers energy from place to place. A mechanical wave starts when matter is disturbed. An example of a mechanical wave is pictured in Figure 19.1. A drop of water falls into a pond. This disturbs the water in the pond. What happens next? The disturbance travels outward from the drop in all directions. This is the wave. A source of energy is needed to start a mechanical wave. In this case, the energy comes from the falling drop of water. The energy of a mechanical wave can travel only through matter. This matter is called the medium (plural, media). The medium in Figure 19.1 is a liquid the water in the pond. But the medium of a mechanical wave can be any state of matter, including a solid or a gas. Its important to note that particles of matter in the medium dont actually travel along with the wave. Only the energy travels. The particles of the medium just vibrate, or move back-and- forth or up-and-down in one spot, always returning to their original positions. As the particles vibrate, they pass the energy of the disturbance to the particles next to them, which pass the energy to the particles next to them, and so on. There are three types of mechanical waves. They differ in how they travel through a medium. The three types are transverse, longitudinal, and surface waves. All three types are described in detail below. A transverse wave is a wave in which the medium vibrates at right angles to the direction that the wave travels. An example of a transverse wave is a wave in a rope, like the one pictured in Figure 19.2. In this wave, energy is provided by a persons hand moving one end of the rope up and down. The direction of the wave is down the length of the rope away from the persons hand. The rope itself moves up and down as the wave passes through it. You can see a brief video of a transverse wave in a rope at this URL: . To see a transverse wave in slow motion, go to this URL: (0:22). MEDIA Click image to the left or use the URL below. URL: A transverse wave can be characterized by the high and low points reached by particles of the medium as the wave passes through. This is illustrated in Figure 19.3. The high points are called crests, and the low points are called troughs. Another example of transverse waves occurs with earthquakes. The disturbance that causes an earthquake sends transverse waves through underground rocks in all directions from the disturbance. Earthquake waves that travel this way are called secondary, or S, waves. An S wave is illustrated in Figure 19.4. A longitudinal wave is a wave in which the medium vibrates in the same direction that the wave travels. An example of a longitudinal wave is a wave in a spring, like the one in Figure 19.5. In this wave, the energy is provided by a persons hand pushing and pulling the spring. The coils of the spring first crowd closer together and then spread farther apart as the disturbance passes through them. The direction of the wave is down the length of the spring, or the same direction in which the coils move. You can see a video of a longitudinal wave in a spring at this URL: http A longitudinal wave can be characterized by the compressions and rarefactions of the medium. This is illustrated in Figure 19.6. Compressions are the places where the coils are crowded together, and rarefactions are the places where the coils are spread apart. Earthquakes cause longitudinal waves as well as transverse waves. The disturbance that causes an earthquake sends longitudinal waves through underground rocks in all directions from the disturbance. Earthquake waves that travel this way are called primary, or P, waves. They are illustrated in Figure 19.7. A surface wave is a wave that travels along the surface of a medium. It combines a transverse wave and a longitudinal wave. Ocean waves are surface waves. They travel on the surface of the water between the ocean", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}484{"query": "James Prinsep was the seventh son and the tenth child of John Prinsep (1746--1830) and his wife, Sophia Elizabeth Auriol (1760--1850).", "pos": "The Honourable Gerald David Lascelles (21 August 1924 -- 27 February 1998) was the younger son of Henry Lascelles, 6th Earl of Harewood and Mary, Princess Royal, the only daughter of King George V of the United Kingdom and Mary of Teck.", "neg": "The Saudades do Brasil (1920), Op. 67, are a suite of twelve dances for piano by Darius Milhaud.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}485{"query": "Pierre Curie died in a street accident in Paris on 19 April 1906.", "pos": "Georgios Papoulias died from an apparent suicide on September 11, 2009, at the age of 82, following serious health problems.", "neg": "It's eight o'clock and the time for Morning New Highlights . One person was killed and two were injured in a car accident just thirty minutes ago. Cause of the accident is not yet found out. A great fire swept through a storehouse next to the Fulton River early this morning, causing about $3,000,000 in damage. The fire which broke out at about 2:30 was finally put out at 5: 30. That was the Morning News Highlights, Dan Verne reporting.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}486{"query": "The urinary system controls the amount of water in the body and removes wastes. Any problem with the urinary system can also affect many other body systems. In some cases, certain mineral wastes can form kidney stones ( Figure 1.1). Stones form in the kidneys and may be found anywhere in the urinary system. Often, stones form when the urine becomes concentrated, allowing minerals to crystallize and stick together. They can vary in size, from small stones that can flow through your urinary system, to larger stones that cannot. Some stones cause great pain, while others cause very little pain. Some stones may need to be removed by surgery or ultrasound treatments. What are the symptoms of kidney stones? You may have a kidney stone if you have pain while urinating, see blood in your urine, and/or feel a sharp pain in your back or lower abdomen (the area between your chest and hips). The pain may last for a long or short time. You may also have nausea and vomiting with the pain. If you have a small stone that passes on its own easily, you may not experience any symptoms. If you have some of these symptoms, you should see your doctor. A kidney stone. The stones can form anywhere in the urinary system. Kidney failure happens when the kidneys cannot remove wastes from the blood. If the kidneys are unable to filter wastes from the blood, the wastes build up in the body. Kidney failure can be caused by an accident that injures the kidneys, the loss of a lot of blood, or by some drugs and poisons. Kidney failure may lead to permanent loss of kidney function. But if the kidneys are not seriously damaged, they may recover. Chronic kidney disease is the slow decrease in kidney function that may lead to permanent kidney failure. A person who has lost kidney function may need to get kidney dialysis. Kidney dialysis is the process of filtering the blood of wastes using a machine. A dialysis machine ( Figure 1.2) filters waste from the blood by pumping the blood through a fake kidney. The filtered blood is then returned to the patients body. Urinary tract infections (UTIs) are bacterial infections of any part of the urinary tract. When bacteria get into the bladder or kidney and produce more bacteria in the urine, they cause a UTI. The most common type of UTI is a bladder infection. Women get UTIs more often than men. UTIs are often treated with antibiotics. Most UTIs are not serious, but some infections can lead to serious problems. Long lasting kidney infections can cause permanent damage, including kidney scars, poor kidney function, high blood pressure, and other problems. Some sudden kidney infections can be life threatening, especially if the bacteria enter the bloodstream, a condition called septicemia. What are the signs and symptoms of a UTI? a burning feeling when you urinate, frequent or intense urges to urinate, even when you have little urine to pass, pain in your back or side below the ribs, cloudy, dark, bloody, or foul-smelling urine, fever or chills. You should see your doctor if you have signs of a UTI. Your doctor will diagnose a UTIs by asking about your symptoms and then testing a sample of your urine.", "pos": "A sexually transmitted infection (STI) is an infection that spreads through sexual contact. STIs are caused by pathogens, a living thing or virus that causes infection. The pathogens enter the body through the reproductive organs. Many STIs also spread through body fluids, such as blood. For example, a shared tattoo needle is one way an STI could spread. Some STIs can also spread from a mother to her baby during childbirth. STIs are more common in teens and young adults than in older people. One reason is that young people are more likely to take risks. They also may not know how STIs spread. They are likely to believe myths about STIs ( Table Myth If you are sexually active with just one person, you cant get STIs. If you dont have any symptoms, then you dont have an STI. Getting STIs is no big deal, because STIs can be cured with medicine. Fact The only way to avoid the risk of STIs is to practice abstinence from sexual activity. Many STIs do not cause symptoms, especially in fe- males. Only some STIs can be cured with medicine; other STIs cannot be cured. Most STIs are caused by bacteria or viruses. STIs caused by bacteria usually can be cured with drugs called antibiotics. But antibiotics are not effective against viruses. Therefore, STIs caused by viruses are not treated with antibiotics. Other drugs may be used to help control the symptoms of viral STIs, but they cannot be cured. Once you have a viral STI, you are usually infected for life. In the U.S., chlamydia is the most common STI caused by bacteria. Females are more likely than males to develop the infection. Rates of chlamydia among U.S. females in 2006 are shown below ( Figure 1.1). Rates were much higher in teens and young women than in other age groups. Chlamydia may cause a burning feeling during urination. It may also cause a discharge (leaking of fluids) from the vagina or penis. But in many cases it causes no symptoms. As a result, people do not know they are infected, so they dont go to the doctor for help. If chlamydia goes untreated, it may cause more serious problems in females. It may cause infections of the uterus, fallopian tubes, or ovaries. These infections may leave a woman unable to have children. Gonorrhea is another common STI. Gonorrhea may cause pain during urination. It may also cause a discharge from the vagina or penis. On the other hand, some people with gonorrhea have no symptoms. As a result, they dont seek treatment. Without treatment, gonorrhea may lead to infection of other reproductive organs. This can happen in males as well as females. Syphilis is a very serious STI. Luckily, it is less common than chlamydia or gonorrhea. Syphilis usually begins with a small sore on the genitals. This is followed a few months later by a rash and flu-like symptoms. If syphilis is not treated, it may damage the heart, brain, and other organs. It can even cause death. Genital warts are an STI caused by human papilloma virus, or HPV. They are one of the most common STIs in teenagers. HPV infections cannot be cured. But a new vaccine called Gardasil can prevent most HPV infections in females. Many doctors recommend that females between the ages of 9 and 26 years receive the vaccine. Preventing HPV infections in females is important because HPV can also cause cancer of the cervix. A related herpes virus causes cold sores on the lips ( Figure 1.2). Both viruses cause painful blisters. In the case of genital herpes, the blisters are on the penis or around the vaginal opening. The blisters go away on their own, but the virus remains in the body. The blisters may come back repeatedly, especially when a person is under stress. There is no cure for genital herpes. But drugs can help prevent or shorten outbreaks. Researchers are trying to find a vaccine to prevent genital herpes. Hepatitis B is a disease of the liver. It is caused by a virus called hepatitis B, which can be passed through sexual activity", "neg": "Sometimes, the urinary system ( Figure 1.1) is called the excretory system. But the urinary system is only one part of the excretory system. Recall that the excretory system is also made up of the skin, lungs, and large intestine, as well as the kidneys. The urinary system is the organ system that makes, stores, and gets rid of urine. 1. As you can see above ( Figure 1.1), the kidneys are two bean-shaped organs. Kidneys filter and clean the blood and form urine. They are about the size of your fists and are found near the middle of the back, just below your ribcage. 2. Ureters are tube-shaped and bring urine from the kidneys to the urinary bladder. 3. The urinary bladder is a hollow and muscular organ. It is shaped a little like a balloon. It is the organ that collects urine. 4. Urine leaves the body through the urethra. The kidneys filter the blood that passes through them, and the urinary bladder stores the urine until it is released from the body. Urine is a liquid that is formed by the kidneys when they filter wastes from the blood. Urine contains mostly water, but it also contains salts and nitrogen-containing molecules. The amount of urine released from the body depends on many things. Some of these include the amount of fluid and food a person consumes and how much fluid they have lost from sweating and breathing. Urine ranges from colorless to dark yellow but is usually a pale yellow color. Light yellow urine contains mostly water. The darker the urine, the less water it contains. The urinary system also removes a type of waste called urea from your blood. Urea is a nitrogen-containing molecule that is made when foods containing protein, such as meat, poultry, and certain vegetables, are broken down in the body. Urea and other wastes are carried in the bloodstream to the kidneys, where they are removed and form urine.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}487{"query": "On March 26, 2008, Ludia (in connection with Ubisoft) launched The Price Is Right video game for PC. A version for the Wii and Nintendo DS platforms was released in September 2008, while a version for the iOS (Apple) was released in November 2008. The shows announcer, Fields, was the host of the computer version. The virtual set in the game resembles the set used in seasons 31 to 34. Ludia announced that all three platforms will receive a new version of the video game that was previewed at the Target Bullseye Lounge during the Electronic Entertainment Expo trade show on June 2-4, 2009. The Price Is Right 2010 Edition was released on September 22, 2009. In the fall of 2010, Ludia developed a multi-player version for Facebook. A third Ludia adaptation, The Price Is Right Decades, featuring set designs, pricing games and prizes taken from the 1970s through 2000s; was initially released for the Wii in October 2011, with an Xbox 360 and iOS release following in November and December. The Price Is Right 2010 Edition and The Price Is Right Decades have also been released as downloads within the PlayStation Store for the PlayStation 3 in May 2010 and April 2012, respectively. Irwin Toys released an electronic tabletop version in 2008 featuring Contestants Row, the Big Wheel, a physical Plinko board with chips, Showcases and seven pricing games. Jakks Pacific released a Plug It in & Play TV Games version of The Price Is Right in 2009, featuring Carey and Fields.", "pos": "A Vampyre Story is a 2008 point-and-click adventure game developed by Autumn Moon Entertainment for Windows, published by Crimson Cow.", "neg": "According to the market research firm SuperData, as of May 2015, the global games market was worth USD 74.2 billion. By region, North America accounted for $23.6 billion, Asia for $23.1 billion, Europe for $22.1 billion and South America for $4.5 billion. By market segment, mobile games were worth $22.3 billion, retail games 19.7 billion, free-to-play Massively multiplayer online game 8.7 billion, social games $7.9 billion, PC Downloadable content 7.5 billion, and other categories $3 billion or less each.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}488{"query": "The 1688 Glorious Revolution replaced James II and VII with his Protestant daughter Mary II and her husband William III and II. Since neither Mary or her sister Anne had surviving children, the 1701 Act of Settlement ensured a Protestant successor by excluding Catholics from the English and Irish thrones, and that of Great Britain after the 1707 Act of Union. When Anne became the last Stuart monarch in 1702, her heir was the distantly related but Protestant Sophia of Hanover, not her Catholic half-brother James Francis Edward. Sophia died two months before Anne in August 1714; her son became George I and the pro-Hanoverian Whigs controlled government for the next 30 years.", "pos": "Bolingbroke then reigned as King Henry IV of England (1399--1413), the first of the descendants of John of Gaunt to hold the throne of England.", "neg": "The French Revolution broke out in 1789. At the time France was in a crisis. The government was badly run and people's lives were miserable. King Louis XIV tried to control the national parliament and raise more taxes. But his effort failed. He ordered his troops to Versailles. The people thought that Louis intended to put down the Revolution by force. On July 14, 1789, they stormed and took the Bastille, where political prisoners were kept. Ever since that day, July 14 has been the French National Day. Louis tried to flee the country in 1792, to get support from Austria and Prussia. However, he was caught and put in prison. In September 1792, the monarchy was abolished _ . In the same year, Louis was executed. A few months later his wife, Marie also had her head cut off. The Revolution of France had frightened the other kings of Europe. Armies from Austria and Prussia began to march against France. The French raised republican armies to defend the nation. The Revolution went through a period of terror. Thousands of people lost their lives. In the end, power passed to Napoleon Bonaparte.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}489{"query": "On 1 January 2016, Moustoir-Remungol, Naizin and Remungol merged becoming one commune called Evellys.", "pos": "On 15 December 2015, Andreze, Beaupreau, La Chapelle-du-Genet, Geste, Jallais, La Jubaudiere, Le Pin-en-Mauges, La Poiteviniere, Saint-Philbert-en-Mauges and Villedieu-la-Blouere merged becoming one commune called Beaupreau-en-Mauges.", "neg": "In 2000, the label moved from Brussels to London and was renamed PIAS Recordings.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}490{"query": "The film opens with Soichi Negishi (Kenichi Matsuama) walking along side his mother to a small country train station. Negishi hopes to move to Japan, and realize his musical dreams, as a pop singer. As he rides away in the train, he sees his younger brother wave to him from a field.Now we are taken to a dark alleyway, where many alternative Japanese youths are entering a club called \"Hell's Gate.\" Inside we see a death metal band(in rather flamboyant attire, and black and white make-up) preforming for a large crowd. This band, is Detroit Metal City. The singer, is then revealed to be Negashi, and why crowd surfing he narrates of his dislike of what he has become.The opening credits roll.We now see Negashi removing his makeup with a rag, and talking a fellow band mate, which is his lazy, bloomer obsessed drummer Terumichi Nishida . He begs Nishida to return a video-game he had let him borrow, out of fear of him losing it. Now the band's bassist Masayuki Wada speaks to Negashi about how well he believed the show had done.The dressing room door bursts open, and with a wild laugh the President Of Death Records(who also seems to be the band's manager) enters, and tosses a cigarette into a ash tray that Wada held, but it simply bounced out and went out of frame. She told them of how well they did, but in remorse Negashi played for her a tape of the pop music he wishes to make. Displeased, she kicked him.Now with a swollen mouth, Negashi leaves the dressing room in his normal attire, and pushes his way through the crowd of oblivious screaming fans, hoping to get a look at the band. He is hit, and begins to bleed from the nose. As he made his way up the stairs, he heard the fans talk of rumors they had heard about the lead singer Krauser, such as his ability to rape many women.Negashi is now on the street, and he is playing his pop music on an acoustic guitar, with people only stoping to glance at him, and then walk away. He stops playing and hears some pop music being played around the corner. As he goes to investigate he sees that the lead singer of the band was an old college friend, and then that a woman standing near him was his college crush Yuri Aikawa.He reflects on the old days, of them all sitting around playing music together, and of his quote \"No music, No dream.\"He is soon at a record store, looking at the latest fashionable cd covers, when he sees Aikawa, and they began to chat, and make plans to meet later at a cafe. Then a blast of near-by music startles him, and he walks to the next isle to investigate. Several DMC fans had gathered to celebrate the release of a new single with head-banging, and loud music. Negashi dislikes the album cover, and complains about a quote that was in his name, that he never said. Aikawa then tells him of her distaste for metal, and how unfashionable she finds Detroit Metal City.Negashi is now in full attire with his band, doing an interview about the new single. His mind is off daydreaming about Aikawa when he realizes it is time for their date and he runs out of the interview to meet her. Negashi is now constantly going back and forth between the date, and the interview, each time forgetting to remove more and more of his DMC attire. With a feeling that negashi was going into the near-by club, she enters in hopes of finding him, but meets Krauser crowd surfing. Negashi in fear, tries to get the crowd to move him away from her, but the get him closer and closer, until he felt his wig began to slip off. The only thing he could do to cover himself, was to lift up her dress, showing her underwear. She calls him a pig, and walks out.Now Negashi is outside of a cafe, and is banging on the wall in", "pos": "The movie opens with the Barden Bellas about to perform at the ICCA championships. One of them, Chloe (Brittany Snow) is running late to the start of the performance. When she arrives she is reprimanded by the older Bellas. As they are about to perform, Aubrey (Anna Camp) tries to assure them she'll do a good job, but is shot down. The group sings 'The Sign'.. and all is going well, until the very end when Aubrey has a solo, and projectile vomits all over the stage and front rows of the audience.Cut to the start of a new year at Barden University, and freshman Beca (Anna Kendrick) is arriving by taxi. While she is receiving directions and her Rape Whistle, a car passes her by, and another student, Jesse (Skylar Austin) is singing along to the radio, and catches her attention.Beca finds her new dorm room, and meets her roommate Kimmy-Jin, who is hostile and unfriendly. Beca's dad, a professor at Barden then arrives, and asks her how she got there. It is revealed that Beca's parents have split up as she refers to her dad's new wife as her 'step monster', and seems very reluctant to be attending College. Beca's dad tries to encourage her to enjoy it, but Beca escapes to the Activities fair.In another dorm room, Jesse is meeting his roommate Benji (Ben Platt), who is into Star Wars and magic.At the Activities fair, we are introduced to the Trebles - one of the Campus singing groups, all male, who are talented and have a high opinion of themselves, especially Bumper (Adam Devine) the lead singer. Jesse and Benji approach the Trebles, as Benji is desperate to join, but Bumper is not impressed with his enthusiasm.Across the campus, the Bellas are now down to just 2 members - Aubrey and Chloe, who are trying to recruit new ones. Due to their disastrous performance at the last Championships, they are not having much luck, and are even ridiculed by 'Baloney Barb' who has tried out for them previously. They are then approached by Fat Amy (Rebel Wilson), an outgoing and quirky student from Tasmania who doesn't hesitate to demonstrate her singing and dancing abilities. They then meet Beca, who quickly rebuffs their offer to audition, saying it is lame, which immediately puts Aubrey offside.Instead of being interested in joining any of the singing groups, Beca has much more of an interest in remixing music on her laptop. She gets a job at the campus radio station, and much to her dismay, so does Jesse.Her dad pays her a visit in her dorm, and gives her an ultimatum - if she makes an effort and joins a group at College , but still doesn't like it by the end of the year, she can quit and follow her true dream of becoming a DJ, and he will help her... but he wants her to really make an effort.As Beca goes into the communal showers singing to herself, Chloe happens to be in the showers as well, and confronts Beca in her shower stall , insisting that she try out for the Bellas. Although Beca is mortified, she sings along with Chloe to 'Titanium'.Finally the auditions are on, and Jesse, Benji and Fat Amy are among the hopefuls trying out, auditioning to 'Since you've been gone'. Beca comes late, and hasn't prepared the audition song, but auditions with 'Cups (miss me when I'm gone)', and Chloe and Jesse are impressed, while Aubrey is unsure. We then see the initiation of the new Bellas including Beca, Fat Amy, Stacie (Alexis Knapp), Cynthia-Rose (Esther Dean) and the very softly spoken Lilly (Hana Mae Lee). They all swear an oath and drink the 'blood of the Bellas who came before them' (wine). Cut to the initiation of the new Trebles.. Jesse has made it, but Benji has not. That night, there is Aca-initiation where all the groups", "neg": "The film is split into three acts, and narrated by one of the protagonists Kari Kamiya who has a role in the first and third act of the film. Kari gives a brief introduction to the world of Digimon, explaining the existence of Digimon, monsters that were created from computer data, and live in another dimension called the Digital World. She continues, explaining she is part of a team called the Digidestined, who are partnered with Digimon to protect the world from evil. There were only a small handful of members at first, but it is added a few members introducing a new character for the film, named Willis, who lives in Colorado. Willis has two twin Digimon named Gummymon and Kokomon, but had no other friends to rely on. This takes us into the first act, on the night in 1995 when Kari and her big brother Tai encountered their first Digimon. Kari also reveals that Willis met his Digimon on the same night.In Highton View Terrace, Tokyo, Japan, Tai awakens in the night and finds Kari observing their fathers computer, where a large Digiegg emerges. The next day, Tai and Kari witness the egg hatch into Botamon, who quickly bonds with Kari. Tai goes to answer the telephone but the call is interrupted. Returning to the bedroom, Tai discovers Botamon has transformed into Koromon, a pink ball-like Digimon resembling a space hopper. This is a process Kari later explains as digivolving, which allows a Digimon to turn into a stronger form, which affects electrical equipment. Kari steals food from the family cat Miko, causing her to attack and scratch both Tai and Koromon. At sunset, Tai and Kari discover Koromon can speak, and he calls them his best friends.That night, another electrical surge causes Koromon to digivolve into Agumon, an enormous but simple-minded dinosaur, who leaps out the window with Kari on his back. Tai pursues them into the night as Agumon wanders the street, scaring Kari when he starts blowing things up with fireballs. A second, enormous Digiegg appears in the sky, hatching to unleash Parrotmon, a large bird-like Digimon able to fire electrical blasts. As Tai reaches Kari, Parrotmon destroys an overpass, burying Agumon under rubble. However, Agumon digivolves into Greymon and battles Parrotmon. Parrotmon knocks Greymon out, but Tai uses Karis whistle to awaken him. Greymon leaps up and obliterates Parrotmon with a fire blast, but the attack destroys him in the process.In narration, Kari explains that she, Tai, and six other children were amongst those who witnessed the battle and were chosen to become the Digidestined. Karis narration about the team acts as a segway into the second act, set in 2000, a year after the events of the television series Digimon Adventure.Koushiro Izzy Izumi, a computer whiz and member of Digidestined, spots a computer virus has somehow appeared on the internet and is attacking something. Getting an image of its target, Izzy amongst thousands of others across the world, witness the virus mutate a Digiegg, causing it to hatch and become a Digimon, which addresses the world with Hello!. Across town, Tai tries to compose an apology letter to his friend Sora Takenouchi after they had a falling out, but he has difficulty deciding whether or not to end the e-mail with love or from. Kari appears, off to a birthday party, sending the e-mail to Sora behind Tais back, but Tai discovers the e-mail was not delivered.A montage follows, showing what the eight Digidestined are up to Sora wanders the streets and checks her hair in a shop window but fails to notice the virus Digimon on a large screen, Joe Kido, the oldest of the group and voice of reason misses a train to an exam for summer school, Matt Ishida and his little brother T.K. are visiting their grandmother in the countryside, Kari attends a friends birthday, and Izzy races for Tais apartment. The eighth member Mimi is absent from home. Tai bemoans to his mother that Kari gets to eat cake and their fridge is empty, so Tais eccentric mother suggests she attempt to make a cake. Izzy appears, informing Tai of", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}491{"query": "Neurological abnormalities associated with spiculated, \"acanthocytic\" red cells in blood have been described as neuroacanthocytosis. This is a heterogeneous group of conditions that can be clearly subdivided on the basis of recent genetic findings. The McLeod Syndrome, one of the core neuroacanthocytosis syndromes, is a rare X-linked disorder caused by mutations of the XK gene, an X-chromosomal gene of unknown function characterized by haemopoietic abnormalities and late-onset neurological and muscular defects. We report two Chilean brothers with the McLeod phenotype who showed important psychiatric features. The diagnosis may be elusive if the presence of acanthocytosis is not properly studied. We describe a method which allowed the diagnosis that unmasked acanthocytosis. Otherwise the condition could have remained undiagnosed as it had been for decades in this family. This syndrome must be considered when assessing a familial movement disorder, specially affecting males with relevant psychiatric features. A reliable test for acanthocytosis assessment is available.", "pos": "The X-linked McLeod neuroacanthocytosis syndrome strongly resembles Huntington's disease and has been reported in various countries world-wide. Herein, we report two Chilean brothers with predominant psychiatric features at disease onset including schizophrenia-like psychosis and obsessive compulsive disorder. Molecular genetic analysis revealed a small deletion in the XK gene (938-942delCTCTA), which has been already described in a North American patient of Anglo-Saxon descent and a Japanese family, presenting with seizures, muscle atrophy or chorea yet absence of psychiatric features. These findings argue against a founder effect and indicate a profound phenotypic variability associated with the 938-942delCTCTA deletion. Our report supports the inclusion of McLeod syndrome in the differential diagnosis of Huntington's disease as well as acute psychosis in male subjects.", "neg": "To investigate whether the effects of nerve growth factor (NGF) inhibition with tanezumab on rats with medial meniscal tear (MMT) effectively model rapidly progressive osteoarthritis (RPOA) observed in clinical trials. Male Lewis rats underwent MMT surgery and were treated weekly with tanezumab (0.1, 1 or 10mg/kg), isotype control or vehicle for 7, 14 or 28days. Gait deficiency was measured to assess weight-bearing on the operated limb. Joint damage was assessed via histopathology. A second arm, delayed onset of treatment (starting 3-8weeks after MMT surgery) was used to control for analgesia early in the disease process. A third arm, mid-tibial amputation, evaluated the dependency of the model on weight-bearing. Gait deficiency in untreated rats was present 3-7days after MMT surgery, with a return to normal weight-bearing by days 14-28. Prophylactic treatment with tanezumab prevented gait deficiency and resulted in more severe cartilage damage. When onset of treatment with tanezumab was delayed to 3-8weeks after MMT surgery, there was no increase in cartilage damage. Mid-tibial amputation completely prevented cartilage damage in untreated MMT rats. These data suggest that analgesia due to NGF inhibition during the acute injury phase is responsible for increased voluntary weight-bearing and subsequent cartilage damage in the rat MMT model. This model failed to replicate the hypotrophic bone response observed in tanezumab-treated patients with RPOA.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}492{"query": "Quinton Spears (born May 11, 1988) is an American football linebacker of the National Football League (NFL), who is currently a free agent.", "pos": "Damien Ryan (born 20 September 1979) is an Australian professional basketball player.", "neg": "On July 15, 2009 Nucleosys was announced to be disbanding.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}493{"query": "Coming off their bye week, the Buccaneers were still looking for their first win of the season. The Bucs traveled to the Louisiana Superdome for their third divisional match-up in a rowthis time, against the New Orleans Saints. The Bucs scored first as rookie QB Bruce Gradkowski threw an 18-yard TD pass to WR Joey Galloway in the first quarter; the Saints responded with a 21-yard field goal from kicker John Carney. The Saints continued scoring, with a 24-yard TD run from RB Deuce McAllister in the second quarter, and a 9-yard TD pass to TE Ernie Conwell in the third quarter. The Bucs finally responded with a 1-yard TD run from FB Mike Alstott, and took the lead in the fourth quarter with Gradkowski's 3-yard TD pass to TE Alex Smith. Unfortunately for the Bucs, a special teams breakdown led to Saints RB Reggie Bush getting his inaugural NFL touchdown on a 65-yard punt return, which sealed the win for the Saints.", "pos": "Trying to snap a four-game losing skid, the Panthers went home for a Week 12 NFC South rematch with the New Orleans Saints. In the first quarter, Carolina got the early lead as kicker John Kasay managed to get a 45-yard field goal for the only score of the period. In the second quarter, the Saints took the lead as QB Drew Brees completed a 1-yard TD pass to WR Lance Moore, along with kicker Olindo Mare getting a 46-yard field goal. The Panthers would end the half as Kasay nailed a 29-yard field goal. In the third quarter, New Orleans pulled away with Brees completing a 1-yard TD pass to TE Billy Miller, getting an 8-yard TD run, and completing a 4-yard TD pass to WR Marques Colston. With their fifth straight loss, not only did Carolina fall to 4-7, but they had also lost seven straight home games (they have yet to win a home game this year). Also, the Panthers offense only managed to get 4 touchdowns in the last five games.", "neg": "Tampa Bay won their second straight game, this one against a team that was highly favored to win. Jameis Winston threw for over 300 yards while Mike Evans received for over 100 yards. The offense was efficient, especially on third down where they went 11 of 15. The defense came up big as well, with safety Chris Conte getting an interception in the end zone, his second straight game with a pick. Rookie kicker Roberto Aguyao, who has struggled throughout the season, went 5/5 on kicks, making 4 field goals and 1 extra point. With this win, the Bucs got back to .500, took sole possession of second place in the NFC South, and improved their road record to 4-1.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}494{"query": "Fostamatinib (R788) is a prodrug rapidly converted to its active metabolite on oral administration. This (known as R406) is a potent inhibitor of spleen tyrosine kinase, required for the expression of a number of proinflammatory cytokines. Fostamatinib has shown significantly superior efficacy (when compared with placebo) in the control of patients with rheumatoid arthritis not responding to methotrexate in Phase II clinical trials. Treatment emergent adverse events with a higher frequency than in those on placebo included diarrhea, hypertension, urinary tract infections, neutropenia and elevated transaminases. The studied doses have shown a linear pharmacokinetic pattern and the administration of methotrexate does not affect it. Fostamatinib may have a role in the therapy of patients with rheumatoid arthritis with poor response to conventional therapy. If these results are confirmed once Phase III studies are completed, it may find a place in the evolving treatment algorithm for rheumatoid arthritis.", "pos": "Spleen tyrosine kinase (Syk) is a cytoplasmic tyrosine kinase involved in signalling in many of the cells that drive immune inflammation. The development of small molecules that inhibit Syk kinase may change the way we treat disorders such as rheumatoid arthritis (RA), as well as a range of other inflammatory diseases. Fostamatinib (R-788) is an orally bioavailable small molecule. It is the prodrug of R406, which is a potent Syk inhibitor. Fostamatinib was developed because it has more favourable physiochemical properties. It is rapidly converted to R406 by intestinal enterocytes. It has been evaluated in experimental models of RA, such as collagen-induced arthritis. In these models, fostamatinib suppressed clinical arthritis, bone erosions, pannus formation and synovitis. A phase II programme with fostamatinib has largely been completed. Three key trials have been published, lasting 12-26 weeks and each enrolling 189-457 patients (875 in total). All these trials involved placebo therapy and patients continued to receive methotrexate in addition to active treatment with fostamatinib. The first dose-ranging trial evaluated three treatment doses in RA patients who had not fully responded to methotrexate therapy. The second trial compared two treatment doses in patients who had not responded to methotrexate therapy. The third trial compared a single treatment dose with placebo in patients who had not responded to biological therapy. The primary outcome measure was the number of patients achieving American College of Rheumatology (ACR) 20% (ACR20) responses. Placebo ACR20 response rates in all three trials were similar (35-38%). All three trials involved one treatment arm receiving fostamatinib 100 mg twice daily; ACR20 responses with this active treatment ranged from 38% to 67%. A meta-analysis of ACR responses in these trials, using responses to the highest dose in each trial for comparisons with placebo therapy in a random effects model, showed a borderline benefit with ACR20 responses. There were more significant differences with ACR50 and ACR70 responses. The reason that this meta-analysis was not more strongly positive is that the third trial, which evaluated patients who had failed to respond to biological treatments, gave negative results. Individual ACR response components, such as changes in swollen joint counts, showed significant differences in the first two trials, but there were no definite treatment benefits in the third trial. Overall, the differences were significant in a meta-analysis of all three trials. The most important adverse reactions were diarrhoea, neutropenia and raised ALT levels, which all showed significant excesses with active treatment compared with placebo. Too few patients have been studied for a definitive safety profile to be known. Overall, the results of the phase II trials were sufficiently encouraging for a phase III programme to be initiated. It will be some years before their definitive results are available.", "neg": "With the recent introduction of inhibitors of mammalian target of rapamycin (mTOR) in oncology, distinct cutaneous and oral adverse events have been identified. In fact, stomatitis and rash are documented as the most frequent and potentially dose-limiting side effects. Clinically, mTOR inhibitor-associated stomatitis (mIAS) more closely resembles aphthous stomatitis than oral mucositis due to conventional anticancer therapies. While most cases of mIAS are mild to moderate and self-limiting, more severe and persistent mIAS can become a dose-limiting toxicity. Small ulcerations may cause significant pain and mucosal sensitivity may occur in the absence of clinical changes. Use of clinical assessment tools that are primarily driven by ulceration size may underestimate mIAS, and assessment should include patient-reported outcomes. This article provides an up-to-date review of the clinical presentation, terminology, pathogenesis, assessment and management of mIAS and other mTOR inhibitor-associated oral adverse events. In addition, areas of future research are considered.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}495{"query": "Mira Bjedov, married Nikolic, (born 7 September 1955 in Mokro Polje) is a former basketball player who competed for Yugoslavia in the 1980 Summer Olympics.", "pos": "Majda Mehmedovic (born 25 May 1990) is a Montenegrin handball player.", "neg": "Marco Solfrini (born 30 January 1958 in Brescia) is a former basketball player from Italy, who won the silver medal with his national team at the 1980 Summer Olympics in Moscow.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}496{"query": "Claire Ridgway (born 1971) is a British writer of history books about the Tudor dynasty, with a particular focus on the life of the Boleyn family.", "pos": "Abi Curtis received a PhD in Creative and Critical Writing from the University of Sussex, and went on to teach there until 2010.", "neg": "Christian Chalmin, publisher, born in 1947 at Autry-Issards and Mayor of the commune from 1989 to 1995.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}497{"query": "In a time when a dangerous number of people are overweight, many people seem to have forgotten the most important way to keep healthy and slim---exercise. And as a new study carried out on mice in the lab has shown, exercise done early in life can reward you in your adult years. A team of researchers at the University of California studied the effects of early exercise on adult physical activity, body mass and eating. They found that early-age exercise in mice has positive effects on adult levels of voluntary exercise in addition to reducing body mass. \"These results may have an effect on the importance of regular physical education in elementary and middle schools,\" said Theodore Garland, a professor of biology, who led the research project. \"If kids exercise regularly through their school years, then they may be more likely to exercise as adults, which could have far-reaching positive effects on human health and well-being.\" Although the positive effects of early-life exercise lasted for only one week, it is important to note that one week in the life of a mouse is the same as about nine months for humans. \"Our results suggest that any positive effects of early-life exercise on adult exercise will need to be kept up if they are to be long-lasting.\" His team of researchers found, too, that all mice that had access to early exercise were lighter in weight than non-exercised mice. Garland explained that, in general, exercise will stimulate appetite sooner or later. However, it is possible that certain types of exercise, done for certain periods of time or at certain light levels, might not _ appetite much, if at all, at least in some individuals. \"If we could understand what sorts of exercise these might be, then we might be able to tailor exercise recommendations in a way that would bring the benefits of exercise without increase in appetite, leading to a better chance of weight loss,\" he said.", "pos": "A dentist's office may not be everyone's idea of a perfect holiday destination.But a growing number of Europeans are travelling abroad for medical treatment to save money,or maybe to combine a visit to the doctor with some sightseeing,creating a potential but fastgrowing market for traditional tour operators. \"It was simply cheaper for me to go to a dentist in Hungary,\" said a 42yearold physical therapist from Berlin.He chose the clinic near Budapest from an Internet advertisement,attracted by hundreds of euros in savings compared with the same treatment in Germany.He was happy to find when he got there that the clinic was clean,the staff qualified and the work thorough. People travel abroad for medical treatment for various reasons:it's cheaper,they face a long wait at home,or the treatment they want is not available in their own country.The Britishbased Medical Tourist Company refers about 100 patients a year to hospitals in India for treatments.And Chief Executive Premhar Shah reports rapid growth in demand from customers in Africa,where it can be harder to find wellequipped medical facilities for complex surgeries. Some patients who have immigrated may prefer to return to be close to their families when they undergo surgery.\"People will want to take the opportunity to seek treatment in places where they have relatives who might be able to look after them.I'm seeing that especially with younger people from eastern Europe,\" said a professor at the University of Oxford. For some,there is the attraction of free treatment abroad.British lawmakers have called for tighter checks on patients arriving for treatment,out of concerns that foreign citizens are travelling to Britain to take advantage of the free service. The global medical tourism market is believed to be worth $40 billion to $60 billion and growing at about 20 percent per year.", "neg": "Our previous work has shown that gene knockout of the sodium-glucose cotransporter SGLT2 modestly lowered blood glucose in streptozotocin-diabetic mice (BG; from 470 to 300 mg/dl) and prevented glomerular hyperfiltration but did not attenuate albuminuria or renal growth and inflammation. Here we determined effects of the SGLT2 inhibitor empagliflozin (300 mg/kg of diet for 15 wk; corresponding to 60-80 mgkg(-1)day(-1)) in type 1 diabetic Akita mice that, opposite to streptozotocin-diabetes, upregulate renal SGLT2 expression. Akita diabetes, empagliflozin, and Akita + empagliflozin similarly increased renal membrane SGLT2 expression (by 38-56%) and reduced the expression of SGLT1 (by 33-37%) vs. vehicle-treated wild-type controls (WT). The diabetes-induced changes in SGLT2/SGLT1 protein expression are expected to enhance the BG-lowering potential of SGLT2 inhibition, and empagliflozin strongly lowered BG in Akita (means of 187-237 vs. 517-535 mg/dl in vehicle group; 100-140 mg/dl in WT). Empagliflozin modestly reduced GFR in WT (250 vs. 306 l/min) and completely prevented the diabetes-induced increase in glomerular filtration rate (GFR) (255 vs. 397 l/min). Empagliflozin attenuated increases in kidney weight and urinary albumin/creatinine ratio in Akita in proportion to hyperglycemia. Empagliflozin did not increase urinary glucose/creatinine ratios in Akita, indicating the reduction in filtered glucose balanced the inhibition of glucose reabsorption. Empagliflozin attenuated/prevented the increase in systolic blood pressure, glomerular size, and molecular markers of kidney growth, inflammation, and gluconeogenesis in Akita. We propose that SGLT2 inhibition can lower GFR independent of reducing BG (consistent with the tubular hypothesis of diabetic glomerular hyperfiltration), while attenuation of albuminuria, kidney growth, and inflammation in the early diabetic kidney may mostly be secondary to lower BG.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}498{"query": "Coming off their home win over the Rams, the Bengals flew to Bill Walsh Field at Monster Park for a Saturday night interconference duel with the San Francisco 49ers. After a scoreless first quarter, Cincinnati trailed early in the second quarter as 49ers QB Shaun Hill got a 3-yard TD run. Afterwards, the Bengals would take the lead as kicker Shayne Graham managed to get a 24-yard field goal, while QB Carson Palmer completed a 52-yard TD pass to WR Chris Henry. San Francisco would end the half with Hill completing a 17-yard TD pass to TE Vernon Davis. In the third quarter, the 49ers increased their lead with kicker Joe Nedney getting a 29-yard and a 38-yard field goal. In the fourth quarter, Cincinnati tried to respond as Graham kicked a 35-yard field goal. However, the 49ers' defense held on for the win. With the loss, the Bengals fell to 5-9, securing Head Coach Marvin Lewis' first losing season with Cincinnati.", "pos": "Playing in their second game of the season, the Cincinnati Bengals had a lot of things go wrong. Playing Ohio state rivals Cleveland Browns, the defense looked the exact opposite as they did in week one. Browns quarterback Derek Anderson started and threw for 328 yards and five touchdowns. It was only the third time in NFL history that two quarterbacks had thrown at least five touchdown passes in the same game. Jamal Lewis had 215 yards rushing with one touchdown and the Browns had two receivers with over 100 yards, Braylon Edwards and Kellen Winslow. The Bengals offense tried their best to keep the team in the game, however, as Carson Palmer threw for 6 TD's and Chad Johnson caught for 209 yards. The game started out slowly in the first quarter but the second quarter saw a combined 35 points scored. It was close in the end, when the Bengals started a drive with under one minute left. They managed to get the ball to the 50-yard line when Carson Palmer was intercepted by Leigh Bodden on an intended pass for Chad Johnson. This game ended up being the eighth highest scoring game in NFL history, but not the highest scoring game between these two teams. In 2004, the Bengals beat the Browns 58-48 for the second-most combined points. The Redskins (72) and Giants (41) combined for 113 points in 1966 for the most. Q1 - CIN - 10:40 - 13-yard TD pass from Carson Palmer to Rudi Johnson (Shayne Graham kick) (CIN 7-0) Q1 - CLE - 5:02 - Phil Dawson 39-yard FG (CIN 7-3) Q1 - CLE - 0:09 - Phil Dawson 39-yard FG (CIN 7-6) Q2 - CLE - 11:02 - 17-yard TD pass from Derek Anderson to Joe Jurevicius (Dawson kick) (CLE 13-7) Q2 - CIN - 7:40 - 23-yard TD pass from Carson Palmer to T. J. Houshmandzadeh (Graham kick) (CIN 14-13) Q2 - CLE - 6:37 - 9-yard TD pass from Derek Anderson to Joe Jurevicius (Dawson kick) (CLE 20-14) Q2 - CIN - 3:12 - 22-yard TD pass from Carson Palmer to Chad Johnson (Graham kick) (CIN 21-20) Q2 - CLE - 1:11 - 25-yard TD pass from Derek Anderson to Kellen Winslow (Dawson kick) (CLE 27-21) Q3 - CIN - 12:13 - Shayne Graham 20-yard FG (CLE 27-24) Q3 - CLE - 8:24 - 34-yard TD pass from Derek Anderson to Braylon Edwards (Dawson kick) (CLE 34-24) Q3 - CIN - 6:18 - 14-yard TD pass from Carson Palmer to Chad Johnson (Graham kick) (CLE 34-31) Q3 - CLE - 6:04 - Jamal Lewis 66-yard TD run (Dawson kick) (CLE 41-31) Q3 - CIN - 0:53 - 5-yard TD pass from Carson Palmer to T. J. Houshmandzadeh (Graham kick) (CLE 41-38) Q4 - CLE - 10:07 - 37-yard TD pass from Derek Anderson to Braylon Edwards (Dawson kick) (CLE 48-38) Q4 - CLE - 5:47 - Phil Dawson 18-yard FG (CLE 51-38) Q4 - CIN - 3:45 - 7-yard TD pass from Carson Palmer to Glenn Holt (Graham kick) (CLE 51-45)", "neg": "This game is well known for an infamous penalty that occurred during the overtime period. The Jets were lining up for a game winning 56-yard field goal in overtime to try and give them the win. Nick folk kicked the ball, but the kick went wide right and the Patriots appeared to be taking over with a chance to win. However, Chris Jones of New England was called for a controversial unsportsmanlike conduct penalty after pushing his teammate into the offensive line. This penalty would later be named \"leaping\". The penalty gave the Jets another chance and made the field goal attempt a 51-yard attempt. This time, Folk drilled the kick, and the Jets would go on to stun the Patriots. With the win, the Jets improved to 4-3.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}499{"query": "On 30 March 1922, a part of the territory of Montigny-les-Cormeilles was detached and merged with a part of the territory of Taverny and a part of the territory of Pierrelaye to create the commune of Beauchamp.", "pos": "On 7 July 1899, a part of the territory of Villiers-sur-Marne was detached and merged with a part of the territory of La Queue-en-Brie and a part of the territory of Chennevieres-sur-Marne to create the commune of Le Plessis-Trevise.", "neg": "Rovering to Success is a book written by Robert Baden-Powell in 1922.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}500{"query": "Borders Group, Inc. (former NYSE ticker symbol BGP) was an international book and music retailer based in Ann Arbor, Michigan.", "pos": "Brepols was once one of the largest printing companies of the world and one of the main employers in Turnhout (Belgium).", "neg": "Armstrong Siddeley was merged with the aircraft engine business of Bristol Aeroplane Company (Bristol Aero Engines) to form Bristol Siddeley as part of an ongoing rationalisation under government influence of the British aircraft and aircraft engine manufacturers.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}501{"query": "After periods with Shamrock Rovers, Shelbourne and University College Dublin A.F.C., O Snodaigh was a squad member of the successful Bray Wanderers side that won the 1989-90 FAI Cup in at Lansdowne Road with a 3-0 victory against St Francis, lost in the European Cup Winners Cup tie against Trabzonspor, and finished runners-up in the 1990-91 League of Ireland First Division. That same year he was a central member of Wanderers reserve side that finished runners-up in the League of Ireland B Division. He won the B team player of the year award in 1990 and was a member of the first team that lost the LFA President's Cup final 3-1 against Dundalk. In time he left Bray and became a member of Leinster Senior League side Pegasus where, over a seven-year period, he was a member of their FAI Intermediate Cup winning team in 1992 against Bluebell United, top scorer in 1996/7, selected for the Leinster Senior League selection team in 1992, was captain of the side that got relegated from the senior division in 1997 following a defeat away to Bluebell and played in every position for the side except goalkeeper.", "pos": "Among the awards Boomer Esiason has earned during his career include the NFL Most Valuable Player Award in 1988 (leading the league with a quarterback rating of 97.4), and the Walter Payton Man of the Year Award in 1995 for his charitable work.", "neg": "What happens inside the skull of a soccer player who repeatedly heads a soccer ball? That question motivate a challenging new study of the brains of experienced players that has caused discussion and debate among soccer players, and some anxiety among those of us with soccer-playing children. For the study, researchers at the Albert Einstein College of Medicine in New York selected 34 adults,men and women. All of the volunteers had played soccer since childhood and now competed year-round in adult soccer leagues. Each filled out a detailed questionnaire developed especially for this study to determine how many times they had headed a soccer ball in the previous year, as well as whether they had experienced any known concussions in the past. Then the players completed computerized tests of their memory and other learning skills and had their brains scanned, using a complicated new MRI technique which can find structural changes in the brain that can't be seen during most scans. According to the data they presented at a Radiological Society of North America meeting last month,the researchers found that the players who had headed the ball more than about 1,100 times in the previous 12 months showed significant loss of white matter in parts of their brains involved with memory,attention and the processing of visual information, compared with players who had headed the ball fewer times. This pattern of white matter loss is \"similar to those seen in traumatic brain injury\" , like that after a serious concussion, the researchers reported,even though only one of these players was reported to have ever experienced a conc ussion. The players who had headed the ball about 1,100 times or more in the past year were also generally worse at recalling lists of words read to them, forgetting or _ the words far more often than players who had headed the ball less.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}502{"query": "Alfred Wegener, born in 1880, was a meteorologist and explorer. In 1911, Wegener found a scientific paper that listed identical plant and animal fossils on opposite sides of the Atlantic Ocean. Intrigued, he then searched for and found other cases of identical fossils on opposite sides of oceans. The explanation put out by the scientists of the day was that land bridges had once stretched between these continents. Instead, Wegener pondered the way Africa and South America appeared to fit together like puzzle pieces. Other scientists had suggested that Africa and South America had once been joined, but Wegener was the ideas most dogged supporter. Wegener amassed a tremendous amount of evidence to support his hypothesis that the continents had once been joined. Imagine that youre Wegeners colleague. What sort of evidence would you look for to see if the continents had actually been joined and had moved apart? Here is the main evidence that Wegener and his supporters collected for the continental drift hypothesis: The continents appear to fit together. Ancient fossils of the same species of extinct plants and animals are found in rocks of the same age but are on continents that are now widely separated (Figure 1.1). Wegener proposed that the organisms had lived side by side, but that the lands had moved apart after they were dead and fossilized. His critics suggested that the organisms moved over long-gone land bridges, but Wegener thought that the organisms could not have been able to travel across the oceans. Fossils of the seed fern Glossopteris were too heavy to be carried so far by wind. Mesosaurus was a swimming reptile, but could only swim in fresh water. Cynognathus and Lystrosaurus were land reptiles and were unable to swim. Wegener used fossil evidence to support his continental drift hypothesis. The fos- sils of these organisms are found on lands that are now far apart. Identical rocks, of the same type and age, are found on both sides of the Atlantic Ocean. Wegener said the rocks had formed side by side and that the land had since moved apart. Mountain ranges with the same rock types, structures, and ages are now on opposite sides of the Atlantic Ocean. The Appalachians of the eastern United States and Canada, for example, are just like mountain ranges in eastern Greenland, Ireland, Great Britain, and Norway (Figure 1.2). Wegener concluded that they formed as a single mountain range that was separated as the continents drifted. Grooves and rock deposits left by ancient glaciers are found today on different continents very close to the Equator. This would indicate that the glaciers either formed in the middle of the ocean and/or covered most of the Earth. Today, glaciers only form on land and nearer the poles. Wegener thought that the glaciers were centered over the southern land mass close to the South Pole and the continents moved to their present positions later on. The similarities between the Appalachian and the eastern Greenland mountain ranges are evidences for the continental drift hypothesis. Coral reefs and coal-forming swamps are found in tropical and subtropical environments, but ancient coal seams and coral reefs are found in locations where it is much too cold today. Wegener suggested that these creatures were alive in warm climate zones and that the fossils and coal later drifted to new locations on the continents. Wegener thought that mountains formed as continents ran into each other. This got around the problem of the leading hypothesis of the day, which was that Earth had been a molten ball that bulked up in spots as it cooled (the problem with this idea was that the mountains should all be the same age and they were known not to be). Click image to the left or use the URL below. URL:", "pos": "First, lets review plate tectonics theory. Plate tectonics theory explains why: Earths geography has changed over time and continues to change today. some places are prone to earthquakes while others are not. certain regions may have deadly, mild, or no volcanic eruptions. mountain ranges are located where they are. many ore deposits are located where they are. living and fossil species are found where they are. Plate tectonic motions affect Earths rock cycle, climate, and the evolution of life. Remember that Wegener used the similarity of the mountains on the west and east sides of the Atlantic as evidence for his continental drift hypothesis. Those mountains rose at the convergent plate boundaries where the continents were smashing together to create Pangaea. As Pangaea came together about 300 million years ago, the continents were separated by an ocean where the Atlantic is now. The proto-Atlantic ocean shrank as the Pacific Ocean grew. The Appalachian mountains of eastern North America formed at a convergent plate boundary as Pangaea came together (Figure 1.1). About 200 million years ago, the they were probably as high as the Himalayas, but they have been weathered and eroded significantly since the breakup of Pangaea. Pangaea has been breaking apart since about 250 million years ago. Divergent plate boundaries formed within the continents to cause them to rift apart. The continents are still moving apart, since the Pacific is shrinking as the Atlantic is growing. If the continents continue in their current directions, they will come together to create a supercontinent on the other side of the planet in around 200 million years. If you go back before Pangaea there were earlier supercontinents, such as Rodinia, which existed 750 million to 1.1 billion years ago, and Columbia, at 1.5 to 1.8 billion years ago. This supercontinent cycle is responsible for most of the geologic features that we see and many more that are long gone (Figure 1.2). Scientists think that the creation and breakup of a supercontinent takes place about every 500 million years. The supercontinent before Pangaea was Rodinia. A new continent will form as the Pacific ocean disappears. Click image to the left or use the URL below. URL:", "neg": "Fossils are the preserved remains of animals, plants, and other organisms from the distant past. Examples of fossils include bones, teeth, and impressions. By studying fossils, evidence for evolution is revealed. Paleontologists are scientists who study fossils to learn about life in the past. Fossils allow these scientists to determine the features of extinct species. Paleontologists compare the features of species from different periods in history. With this information, they try to understand how species have evolved over millions of years ( Figure below). Until recently, fossils were the main source of evidence for evolution ( Figure below). Through studying fossils, we now know that todays organisms look much different in many cases than those that were alive in the past. Scientists have also shown that organisms were spread out differently across the planet. Earthquakes, volcanoes, shifting seas, and other movements of the continents have all affected where organisms live and how they adapted to their changing environments. There are many layers of rock in the Earths surface. Newer layers form on top of the older layers; the deepest rock layers are the oldest. Therefore, you can tell how old a fossil is by observing in which layer of rock it was found. Evolution of the horse. Fossil evi- dence, depicted by the skeletal frag- ments, demonstrates evolutionary mile- stones in this process. Notice the 57 million year evolution of the horse leg bones and teeth. Especially obvious is the transformation of the leg bones from having four distinct digits to that of todays horse. The fossils and the order in which fossils appear is called the fossil record. The fossil record provides evidence for when organisms lived on Earth, how species evolved, and how some species have gone extinct. Geologists use a method called radiometric dating to determine the exact age of rocks and fossils in each layer of rock. This technique, which is possible because radioactive materials decay at a known rate, measures how much of the radioactive materials in each rock layer have broken down ( Figure 1.3). Radiometric dating has been used to determine that the oldest known rocks on Earth are between 4 and 5 billion years old. The oldest fossils are between 3 and 4 billion years old. Remember that during Darwins time, people believed the Earth was just about 6,000 years old. The fossil record proves that Earth is much older than people once thought.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}503{"query": "''Down on Love'' was the fifth and final single taken from the album Agent Provocateur by the band Foreigner, and primarily released only in the U.S. in September 1985.", "pos": "Electric Cafe is the ninth studio album by the electronic group Kraftwerk, originally released in 1986.", "neg": "The DeLorean DMC-12 (commonly referred to simply as the DeLorean as it was the only model ever produced by the company) is a sports car manufactured by John DeLorean's DeLorean Motor Company for the American market from 1981--83.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}504{"query": "The scene opens with Ellen (Sharon Stone) riding across the prairie toward a town, when an idiot digging multiple holes looking for his gold, shoots at her. She falls off her horse and knocks him out as he checks to see if she is dead. After chaining him to his wagon, she continues into town. A large, single elimination gun fighting tournament is about to begin and she is looking for revenge on the man ( Herod/Gene Hackman) who killed her father. She arrives at the bar/hotel. Ace Hanlon shows off his deck of cards with an ace for every man he has killed. Soon, the saloon comes to life as Scars who just got out of jail, comes back to settle a score. He makes a move on Ellen, and she tells him to take a bath. Scars gets angry and kicks the blind boy's peddling wagon, as he was talking to Ellen. Later at the drafting of the tournament, the saloon owner is to sign up 16 gunfighters. Among them are The Kid (Leonardo DiCaprio), Sgt. Cantrell (Kieth David), Cort, the marksman and odds on favorite (Russell Crowe) though he was signed up against his will. Cort was an outlaw who became a preacher and built a mission. Since he was one of Herod's partners in crime, Herod now wants Cort dead. Also in the contest is Ace Hanlon ( Lance Herrickson), A Swedish Champ. and of course Herod. Anyone can challenge anyone, and each fighter must accept the first challenge. Ellen is challenged by the idiot who was digging for his lost gold. But up first was the Kid and he quickly shot the Swede and the winner is the last standing.The Swede was shot twice and then threw his gun down. Also winning, were Stg. Cantrell, Scars, and Eugene the scumbag. Herod has challenged Ace(because he thinks Ace was hired to kill him) and one of Herod's men challenged Cort. After Rusty, another of Herod's men has beaten Cort up as he was chained to a fountain in the middle of the village. Herod has Cort released so that he can go to the Kid's gun store. Herod gives Cort the cheapest gun in the place. The Kid also has told everyone that Herod was his father. Herod denies that and rubs it in the Kid's face. Then Cort went out to a fight that he refused to be in. But when the clock stuck, only one bullet was fired. Herod's man fell to the ground. Many claimed to be the fastest gun in town, like the Kid, Herod, and Ace, but all knew that Cort was the fastest. Next, Ace is bragging and doing gun tricks. It is time for he and Herod to face each other. Herod proves that Ace has been lying about all of his kills. The clock strikes and Herod blows Ace's right thumb off. Then he shoots Ace's left hand. Then after mocking Ace some more, Herod's shoots him in the chest. Then Ellen wins her first fight with Cort's help. The next day, Herod invites Stg. Cantrel to his home. He tells the Sgt, that he knows that he was the hired hand and not Ace. The Sgt. does not tell him much and the challenge has been issued. Later, Herod changes the rules and now all fights are to the death. Herod takes down Cantrell, and then scolds the crowd for hiring him. Meantime, Eugene the scum bag is heard upstairs molesting a girl. He comes downstairs and brags about it. Ellen attacks him from behind and the two scream at each other until the challenge is made. though it is pouring outside, The two come out firing and Eugene gets his manhood shot off. The rules have changed and the winner is the last alive. Ellen couldn't finish him off, so she returned to the bar. Eugene comes in and shoots her glass. Then Ellen empties her gun into him.Though Herod tells the Kid to quit, that he has proven his point, the Kid stays in and takes", "pos": "Sam Gillen (Van Damme) is a convict who gets sprung from Federal custody somewhere in the Midwest by his bank-robbing partner. In their last heist, Sam's partner killed a bank guard, and Sam took the rap for it. Sam's partner gets killed in the break, forcing Sam to go it alone in search of the loot, which is buried on the property of a farm inhabited by Clydie Anderson (Arquette), the widowed mother of two kids named Mike \"Mookie\" Anderson and Bree Anderson.Attempting to sneak into Clydie's house and \"borrow\" some salt for a campfire-broiled steak, Sam catches sight of Clydie taking a shower. The next morning, Sam is spotted bathing outdoors by Mookie. After saving Clydie, Mookie, and Bree from a trio of intruding thugs, Sam discovers that Clydie is holding out from selling her place to property developer Franklin Hale, who fears that he will be put out of business if he doesn't get Clydie's land so he can develop on it.Sam decides to hang around, sleeping first in Clydie's barn and then in her bed while repairing her late husband's Triumph motorcycle. And Hale hires an intimidation expert named Dunston, to force Clydie into selling her land. Secretly on Hale's payroll is corrupt sheriff Lonnie Cole, a sometime lover of Clydie.A jealous Lonnie discovers Sam's true identity and threatens to expose him if he doesn't leave. Not wanting to place Clydie in additional danger for helping a fugitive, Sam decides to leave, only to find that Hale has already blown the whistle on him in an attempt to get him out of the way. After evading police chasing him in cars, land rovers, helicopters, and on motorcycles and horseback, Sam returns to save Clydie from Dunston and Hale, who are planning to burn down her house.After fighting off the bad guys and getting Hale caught holding a gun to Clydie's head, he decides to turn himself in, rather than run away. He promises to be back to live with them.", "neg": "Lindsay (Ashley C. Williams) and Jenny (Ashlynn Yennie), two American tourists in Germany, are drugged and involuntarily detained by crazed surgeon Dr. Josef Heiter (Dieter Laser) when they seek help at his house after they get a flat tire. The women awake in a makeshift medical ward. They witness Heiter kill a kidnapped truck driver after Heiter informs him he is \"not a match\". Heiter secures a new male captive, Japanese tourist Katsuro (Akihiro Kitamura). The doctor explains that he is a world-renowned expert at separating Siamese twins, but dreams of making new creatures by sewing people together. He describes in detail how he will surgically connect his three victims mouth-to-anus, so that they share a single digestive system. After Lindsay tries to escape and fails, Heiter explains that he had previously experimented with creating what he called a \"three-dog\", also joined mouth-to-anus. However, the three-dog died shortly after surgery. Heiter tells Lindsay that one dog tried to escape and that dog became the middle, thus this caused the most pain to the dog and as punishment for her escape attempt, she will become the middle part of his centipede. Heiter performs the surgery, placing Katsuro at the front, Lindsay in the middle and Jenny at the rear. He removes the front teeth of both women and mutilates the buttocks of both Katsuro and Lindsay in order to provide easier access to the rectums, to which he hideously stitches and grafts their mouths. During his procedure, he severs the ligaments within his victims' knees to prevent leg extension, forcing his victims to crawl. He then connects his victims together in a straight line with their mouths surgically attached to the anus of the victim in front of them. Once the operation is complete, Heiter attempts to train his centipede as a pet, often belittling Katsuro with racist insults and beating him with a crop when he becomes rebellious. When Katsuro defecates, Lindsay is forced to swallow his excrement while the doctor watches in delight. However, he eventually becomes irritated after being kept awake by the constant screaming of Katsuro (who, as the front part of the centipede, has his mouth free and is still able to speak) and the realization that Jenny is dying from septicemia. When two detectives, Kranz (Andreas Leupold) and Voller (Peter Blankenstein), visit the house to investigate the disappearance of tourists, Heiter comes up with an idea to add them as replacements for Jenny in a new creation; a four-segment centipede. He offers the two detectives water spiked with sedatives in hopes of knocking the two unconscious. After being given the water, the detectives become suspicious and obtain a search warrant for his home. While the detectives leave Heiter's home, the victims attempt to escape. Katsuro attacks Heiter in the process. Their attempt to escape ultimately fails. Katsuro confesses to the doctor that he deserves his fate because he had treated his own family poorly, then commits suicide by slitting his throat with a glass shard. Upon returning to Heiter's home, the detectives forcefully conduct separate searches as an injured Heiter hides near his swimming pool. Kranz finds the ward along with Heiter's victims. Voller begins to feel ill from the earlier drugging, and Heiter stabs him with the scalpel pulled from his leg during Katsuro's attack. Upon finding Voller dead, Kranz is shot by Heiter with Voller's sidearm. Kranz responds by shooting Heiter in the head before dying. Back in the house, Jenny and Lindsay hold hands as Jenny dies. Lindsay sobs as she is left alone in the house, trapped between her deceased fellow captives. Her fate is left unknown. The film ends with the sounds of her sobbing while the camera pans to the roof of the house.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}505{"query": "Christopher George died of a sudden heart attack on the late evening of November 28, 1983 in a Westside Hospital in Los Angeles, California at the age of 52.", "pos": "Nelson Goncalves died of a heart attack at the age of 79.", "neg": "Rene Bliard (18 October 1932 -- 27 September 2009) was a professional French football striker who was a member of Stade de Reims in the 1950s.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}506{"query": "The Turin King List, also known as the Turin Royal Canon, is an Egyptian hieratic papyrus thought to date from the reign of Pharaoh Ramesses II, now in the Museo Egizio (Egyptian Museum) in Turin.", "pos": "The Antinous Farnese is a specific marble sculptural representation of Antinous, named after its one-time owners the Farnese family.", "neg": "Ptolemy III Euergetes (Greek: , Ptolemaios Euergetes, reigned 246--222 BC) was the third king of the Ptolemaic dynasty in Egypt.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}507{"query": "There is always a man who stands on different comers of the street in our city, holding a sign that reads \"Will work for food for my family\". Normally I don't have much money to help him. When my mother is with me and she sometimes makes me pull over and then she will hand him some money. Tonight, I was on my way to the store to get some milk when I saw the man. My daughter and her friend were in the car. We all felt awful that this man was standing out in the cold, wet weather. Many people had made comments that he should be able to work. I often wondered why he would stand out there rather than be in the warmth of a building, working. Well, he might not have an address, and he may need an address in order to apply for a job. Either way, I don't feel it is _ to judge. As I was sharing that feeling with my daughter and her friend, I decided that I needed to help this man. I wanted to show the girls the importance of helping others, not about worrying whether he was legitimately struggling or not. So, when we pulled over to give him some money, I said, \"God bless you,\" and he said it back to us. But the girls and I were still concerned that he would be cold, standing out in the bad weather. So we got him a hot chocolate and a hamburger. My daughter handed them to him and l told the man that the girl wanted to help him because she was worried about him being cold. He was very sweet and appreciative. We all left with smiles, especially me, because, as we were pulling away, the girls were talking about ways they could raise money to help the man and others like him. It was the best trip I have ever made to get milk!!!", "pos": "It was a cold night in Washington, D. C., and I was heading back to the hotel when a man approached me. He asked if l would give him some money so he could get something to eat. I'd read the signs \"Don't give money to beggars.\" So I shook my head and kept walking. I wasn't prepared for a reply, but he said, \"I really am homeless and I really am hungry! You can come with me and watch me eat!\" But I kept on walking. The incident bothered me for the rest of the week. I had money in my pocket and it wouldn't have killed me to hand over a buck or two even if he had been lying. Flying back to Anchorage, I couldn't help thinking of him. I tried to rationalize my failure to help by thinking government agencies, churches and charities were there to feed him. Besides, you're not supposed to give money to beggars. Somewhere over Seattle, I started to write my weekly garden column for The Anchorage Daily News. _ , I came up with an idea. Bean's Cafe, the soup kitchen in Anchorage, feeds hundreds of hungry Alaskans every day. Why not try to get all my readers to plant one row in their gardens dedicated to Bean's? Dedicate a row and take it down to Bean's. Clean and simple. The idea began to take off. Readers would fax or call me when they got something in their garden. Those who only grew flowers donated them. Food for the spirit. In 1995, the Garden Writers Association of America held their annual convention in Anchorage and after learning of Anchorage's program, Plant a Row for Bean's became Plant a Row for the Hungry. The original idea was to have every member of the Garden Writers Association of America write or talk about planting a row for the hungry sometime during the month of April. As more and more people started working with the Plant a Row idea, new changes appeared unexpectedly. Many companies gave free seed to customers and displayed the logo, which also appeared in national gardening publications. Row markers with the Plant a Row logo were delivered to gardeners to set apart their \"Row for the Hungry.\" Garden editor Joan Jackson, supported by The San Jose Mercury News and California's nearly year-round growing season, raised more than 30,000 pounds of fruits and vegetables her first year, and showed GWAA how the program could really work. Texas fruit farms donated food to their local food bank after being inspired by Plant a Row. Today the program continues to thrive and grow. I am surprised that millions of Americans are threatened by hunger. If every gardener in America--and we're seventy million strong--plants one row for the hungry, we can make quite a decrease in the number of neighbors who don't have enough to eat. Maybe then I will stop feeling guilty about abandoning a hungry man I could have helped.", "neg": "The neighborhood \"La Estrella\" is a little and poor neighborhood in the south of Bogota mostly inhabited by people displaced by violence, by years are awaiting all the public service but above all the electric light. The day of his arrival, despite the negativism of many, the electricity comes and is greeted with jubilation around the neighborhood. The district is grateful to the two most important families, the Brochero and Cristancho. The next day, despite the fact that electricity was not yet installed in homes, Cayetano Brochero propose steal electricity directly from the posts along with his best friend Miguel Cristancho and the whole neighborhood. Kennedy Corzo, the mayor of the neighborhood knows the consequences of pirating electricity and vainly tries to convince all the people that such action could lead to jail. The trouble starts when a dangerously cable passes through the Cristancho's clothesline of just when Consuelo Cristancho when go to hanging clothes and the cable from the house of his neighbor and best friend's the Brochero family. Consuelo asks her husband Miguel to tell Cayetano to remove the cable, but after a football game and a binge of both, Cayetano forget to remove the cable. At night when Cayetano and his son Edson saw a football game in TV, Consuelo scolds Miguel to remind Cayetano and after a while seeing as Consuelo talking to another neighbor, feels challenged with a test of manhood and for that cuts cable of Brochero. The next day Brochero collect even angry questioning who had won the game last night and Miguel apologizes and admits to having cut the cable, but as a \"joke.\" Even angry, Cayetano seeks a toy rat, belonging to his cat \"Tapete\" and puts it into the \"changua\" traditional Colombian soup that gave Cristacho daily for breakfast in the neighborhood, when Corzo and attorney Maria Angelica went to the place to tell the consequences of pirating electricity, finds the rat is what makes the other diners to flee the restaurant soup spitting and going to the pharmacy of Cayetano believing the toy was a real rat and the soup was tainted. That same day, Edson Brochero had his confirmation ceremony in the neighborhood chapel and prepare for it unless Johana Cristancho, his loved neighbor who had to sing at the ceremony because his mother forbids her to go. Kennedy speaks with Cayetano and Miguel and both lead him to believe that their friendship is unbreakable, but later held a reception to celebrate the confirmation but come Consuelo and her daughter Johana, then Consuelo drunks Albino, a homeless neighbor and ruining the cake made in honor of Edson, causing the wrath of Brochero. Albino next day he apologizes and fights with neighbors who tease him and then illegally Consuelo gets the row that they made all the neighbors for water service and cause another fight, Albino casually spoils the car with groceries and Kennedy vainly tries to calm the fight. On the other hand Edson meets Johana and the young man proposes to convince their parents to stop the fight they have, Johana says that his mother would make peace with them if Brochero knees apologizing. Both reach a small hill where they declare their love secret and at night besides the bride and groom declare they make love, unaware that his parents that his fight with the neighborhood divided between those who supported the Brochero and those who supported the Cristancho prepare for an attack on another family. Cristancho hang the cat from the Brochero and those with molotov cocktails retaliatory fire to the house Cristancho. Kennedy calls the fire presence calm down but after accomplishing nothing goes to calm the fight for bad manners and meets Edson and Johana who they had seen the fire and Edson advantage that most of the neighborhood was confesses to having had sex with Johana just to humillates Cristancho, angry Miguel challenges Cayetano and his people to a fight to death. All present with the exception of Johana, his little brother and her grandfather are in the field of the neighborhood with weapons to kill each other, Kennedy unsuccessfully with a gun makes them think of intolerance generated by the arrival of electricity and when both sides start a fight to death, not wanting to shoot at Kennedy make the electricity pole which falls to the ground in the rain and everyone is electrocuted. The next morning, the power", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}508{"query": "Singles' Day, also called Double Eleven, began as a day for unmarried or uncoupled people to celebrate their lives on November 11, 1993. In China, however, Singles' Day has become the biggest online shopping day in the world, which was created in 2009 by Alibaba's CEO Daniel Zhang to increase online sales. Since then, it has grown into a cultural phenomenon. China Singles' Day, as a shopping day, takes place on November 11 each year. There are sharp _ and other promotions designed by Alibaba to attract online customers. In 2015, E-commerce giant Alibaba broke records with sales of $14.3 billion on China Singles' Day, with online sales increasing 60 percent from last year, according to Alibaba. \"Most people shop on mobile phones or ipads and online shopping has become a comfortable channel for most consumers\", said Kitty Fok, China manager for market research. \"China is a big market with close to one billion smart, connected device users. It is good news for both Alibaba and their competitors,\" she said. The company is focusing on international e-commerce for future Singles' Days, reported Reuters. \"Within the next five years, we expect China will become the world's largest e-commerce market for imported products,\" President Michael Evans told reporters on Wednesday. Alibaba Chief Executive Daniel Zhang said in a statement that Singles' Day would mean that \"the whole world will see the power of Chinese consumption.\" Over 130 million users visited Alibaba's marketplace app, Taobao, reported the BBC.", "pos": "As people in China celebrated Singles' Day on November 11, the media eagerly discussed why so many marriageable young people fail to find their other half. While single people in China are pitied, their counterparts in some Western countries feel they are being discriminated against. In the US, where more than a quarter of all households consists of one person, single people often pay more insurance than married people. They don't get the same tax breaks and they seldom get promoted at work. There seems to be a bad name attached to their status - somehow their personality is flawed and therefore they are not to be trusted. Activities have created the term \"singlism\" to describe discrimination against unmarried people. It means stereotyping , stigmatizing and discrimination against those who are single. Globally, the number of people living alone is skyrocketing. Many people are at peace with being single and some even choose to remain single. But why are so many of us worried about singledom? Michael Cobb, professor of English at the University of Toronto in Canada, says that pop culture is to blame for people's fear of singledom. His book Single: Arguments for the Uncoupled is a critical examination of singleness in favor of the couple, making singletons one of the most despised sexual minorities in Western countries. In pop culture, singles are viewed as immature, whereas fully adults are able to form relationships and live meaningful lives. The overall message is clear: go ahead and be yourself, but if you want real happiness, make sure you get coupled up. You may get that idea from US comedy series Sex and the City and the most recent Girls, or UK's Bridge Jones' Diary.", "neg": "Modeled after US hot website.com, group buying websites are now popular in China. These websites use the power of group buying to get competitive discounts for a daily deal on some best stuff to do, see, eat and buy in the cities across China. Discounts are available within just one click. Zhao lei, a software engineer in Beijing, loves the one-hour lunch break at noon,as it is the best time for him to check \"today's special\" at his favorite group buying websites . Sometimes he searches for great deals at directory sites devoted to the new shopping space. Zhao spends around 800 yuan($117.65) on group buying every month, mostly to buy food coupons for eating at some nice restaurants and occasionally to find something fun to do. \" I love group buying. In addition to the competitive discounts it offers, it helps me get something fun, exciting and new, and such surprises give me a reason to try something new,\" he said. When he finds a really good bargain, he will send the link to friends or colleagues through MSN,QQ, or e-mail, or share the information at some social networking websites. In doing so, he often gets a certain cut off the price. At some sites, buyers are invited to leave notes about what they want to buy and the website will consider it if similar applications reach a certain number. That is how Zuo got her digital camera after waiting for two months. \"It is cool. I want to buy a new digitgal camera for my trip to Switzerland this winter, but I never expected such cheap prices!\" Zuo said.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}509{"query": "The revolt of the pitauds was a French peasants' revolt in the mid-16th century. The revolt was sparked by the 1541 decree of Chatellerault, which extended a salt tax to Angoumois and Saintonge . It was made compulsory to purchase salt from the salt loft . \"Gabelle\" officers took charge of punishing the unlawful trading of salt. But these were salt pan areas where the salt was freely traded. Salt smuggling spread rapidly, especially after the Marennes and La Rochelle revolts in 1542, and the repression by the salt riders is out of the population acceptance. In 1548, riots break out in Angoumois and Saintonge demanding the release of the smugglers . The de Pitauds revolt grew to 20,000 members, led by a lord and joined by priests. Castles were plundered and salt-tax collectors killed. The revolt spread to Bordeaux where 20 salt tax collectors were killed, including the lieutenant governor, on August 21, 1548. King Henry II blockaded Bordeaux and launched his repression. Bordeaux lost its privileges. It was disarmed, paid a fine, saw its parliament suspended, and 1,401 people were sentenced to death. The repression spread to the countryside where the leaders were hanged: neither priests nor gentlemen were spared. The salt-tax was finally abolished in these provinces in June 1549, the provinces became redeemed countries, and the King issued a general amnesty.", "pos": "The Peasant revolt in Flanders 1323-1328 was a popular revolt in late medieval Europe. Beginning as a series of scattered rural riots in late 1323, peasant insurrection escalated into a full-scale rebellion that dominated public affairs in Flanders for nearly five years until 1328. The uprising in Flanders was caused by both excessive taxations levied by the Count of Flanders Louis I, and by his pro-French policies. The insurrection had urban leaders and rural factions which took over most of Flanders by 1325. The revolt was led by Nicolaas Zannekin, a rich farmer from Lampernisse. Zannekin and his men captured the towns of Nieuwpoort, Veurne, Ypres and Kortrijk. In Kortrijk, Zannekin was able to capture the count himself. In 1325, attempts to capture Gent and Oudenaarde failed. The King of France, Charles IV intervened, whereupon Louis was released from captivity in February 1326 and the Peace of Arques was sealed. The peace soon failed, and the count fled to France when more hostilities erupted. Louis convinced his new liege Philip VI of France to come to his aid, and Zannekin and his adherents were decisively defeated by the French royal army in the Battle of Cassel.", "neg": "The French Revolution broke out in 1789. At the time France was in a crisis. The government was badly run and people's lives were miserable. King Louis XIV tried to control the national parliament and raise more taxes. But his effort failed. He ordered his troops to Versailles. The people thought that Louis intended to put down the Revolution by force. On July 14, 1789, they stormed and took the Bastille, where political prisoners were kept. Ever since that day, July 14 has been the French National Day. Louis tried to flee the country in 1792, to get support from Austria and Prussia. However, he was caught and put in prison. In September 1792, the monarchy was abolished _ . In the same year, Louis was executed. A few months later his wife, Marie also had her head cut off. The Revolution of France had frightened the other kings of Europe. Armies from Austria and Prussia began to march against France. The French raised republican armies to defend the nation. The Revolution went through a period of terror. Thousands of people lost their lives. In the end, power passed to Napoleon Bonaparte.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}510{"query": "Pittosporum viridulatum is a critically endangered species of plant in the Pittosporaceae family.", "pos": "Ravenea rivularis is an endangered species of flowering plant in the Arecaceae family.", "neg": "Language Matters with Bob Holman is a 2015 documentary which focuses upon the rapid extinction of many of planet Earth's human languages and the multifarious struggles and efforts to save and preserve them.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}511{"query": "Neuroacanthocytosis syndromes are mainly comprised of two diseases: chorea-acanthocytosis (ChAc) and McLeod syndrome (MLS). There is a high incidence of psychiatric disorders such as mood disorder and schizophrenia among neuroacanthocytosis patients. We hypothesized that neuroacanthocytosis-related-genes might be associated with susceptibility to these psychiatric disorders. We performed a comprehensive mutation screen of VPS13A and XK, the gene responsible for ChAc and MLS, respectively, in 85 mood disorder subjects and XK in 86 schizophrenia subjects and compared the variants to 100 or more control alleles. We also performed copy number variation (CNV) analysis in 72 mood disorder subjects and 86 schizophrenia subjects. We identified three non-synonymous, two synonymous and six intron variants in mood disorder subjects and a novel GAT triplet repeat polymorphism in VPS13A. By CNV analysis, we identified a heterozygous exon 60-61 deletion in VPS13A in one mood disorder subject. We identified one non-synonymous and one intron variant in mood disorder and schizophrenia subjects, respectively, in XK. The presence of a pathogenic mutation or a potentially functional variant in mood disorder or schizophrenia subjects suggests that neuroacanthocytosis-related-genes might be involved in the pathogenesis of these psychiatric disorders.", "pos": "Neurological abnormalities associated with spiculated, \"acanthocytic\" red cells in blood have been described as neuroacanthocytosis. This is a heterogeneous group of conditions that can be clearly subdivided on the basis of recent genetic findings. The McLeod Syndrome, one of the core neuroacanthocytosis syndromes, is a rare X-linked disorder caused by mutations of the XK gene, an X-chromosomal gene of unknown function characterized by haemopoietic abnormalities and late-onset neurological and muscular defects. We report two Chilean brothers with the McLeod phenotype who showed important psychiatric features. The diagnosis may be elusive if the presence of acanthocytosis is not properly studied. We describe a method which allowed the diagnosis that unmasked acanthocytosis. Otherwise the condition could have remained undiagnosed as it had been for decades in this family. This syndrome must be considered when assessing a familial movement disorder, specially affecting males with relevant psychiatric features. A reliable test for acanthocytosis assessment is available.", "neg": "To investigate whether the effects of nerve growth factor (NGF) inhibition with tanezumab on rats with medial meniscal tear (MMT) effectively model rapidly progressive osteoarthritis (RPOA) observed in clinical trials. Male Lewis rats underwent MMT surgery and were treated weekly with tanezumab (0.1, 1 or 10mg/kg), isotype control or vehicle for 7, 14 or 28days. Gait deficiency was measured to assess weight-bearing on the operated limb. Joint damage was assessed via histopathology. A second arm, delayed onset of treatment (starting 3-8weeks after MMT surgery) was used to control for analgesia early in the disease process. A third arm, mid-tibial amputation, evaluated the dependency of the model on weight-bearing. Gait deficiency in untreated rats was present 3-7days after MMT surgery, with a return to normal weight-bearing by days 14-28. Prophylactic treatment with tanezumab prevented gait deficiency and resulted in more severe cartilage damage. When onset of treatment with tanezumab was delayed to 3-8weeks after MMT surgery, there was no increase in cartilage damage. Mid-tibial amputation completely prevented cartilage damage in untreated MMT rats. These data suggest that analgesia due to NGF inhibition during the acute injury phase is responsible for increased voluntary weight-bearing and subsequent cartilage damage in the rat MMT model. This model failed to replicate the hypotrophic bone response observed in tanezumab-treated patients with RPOA.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}512{"query": "The ubiquitin-proteasome pathway is involved in intracellular protein turnover, and its function is crucial to cellular homeostasis. First synthesized as probes of proteolytic processes, proteasome inhibitors began to be thought of as potential drug candidates when they were found to induce programmed cell death preferentially in transformed cells. They made their first leap into the clinic to be tested as therapeutic agents 10 years ago, and since then, great strides have been made in defining their mechanisms of action, their clinical efficacy and toxicity, and some of their limitations in the form of resistance pathways. Validation of the ubiquitin-proteasome pathway as a target for cancer therapy has come in the form of approvals of the first such inhibitor, bortezomib, for relapsed/refractory multiple myeloma and mantle cell lymphoma, for which this agent has become a standard of care. Lessons learned from this first-in-class agent are now being applied to the development of a new generation of proteasome inhibitors that hold the promise of efficacy in bortezomib-resistant disease and possibly in a broader spectrum of diseases. This saga provides a salient example of the promise of translational medicine and a paradigm by which other agents may be successfully brought from the bench to the bedside.", "pos": "Gefitinib, the specific inhibitor of the epidermal growth factor receptor (EGFR), may cause growth delay in cancer cell lines. Thorough understanding of the downstream cellular signaling of gefitinib will facilitate the discovery of biomarkers for predicting outcomes and monitoring anti-EGFR therapies, and provide information for key targets for therapeutic intervention. In this study, we investigated the role of transducer of erbB2.1 (TOB1) in gefitinib therapy. Using the lung carcinoma cell lines A549 and NCI-H1975, the results suggested that gefitinib might mediate cell cycle arrest in lung cancer cells at least by targeting TOB1 expression. Gefitinib treatment caused cell cycle arrest predominantly at the G1 phase, which is associated with TOB1 nuclear translocation and its interaction with cyclin D1. We also showed that knockdown of TOB1 expression by RNAi rescued lung cancer cells from gefitinib-induced cell-proliferative arrest. These results suggest that TOB1 interaction with cyclin D1 and nuclear translocation is directly involved in the gefitinib-induced anti-proliferative cell cycle arrest.", "neg": "The multidrug resistance 1 gene (MDR1) encodes P-glycoprotein (Pgp), a member of the ATP-binding cassette (ABC) transporter family that confers tumor drug resistance by actively effluxing a number of antitumor agents. We had previously shown that MDR1 transcription is regulated by epigenetic events such as histone acetylation, and had identified the histone acetylase P/CAF and the transcription factor NF-Y as the factors mediating the enzymatic and DNA-anchoring functions, respectively, at the MDR1 promoter. It has also been shown that MDR1 activation is accompanied by increased methylation on lysine 4 of histone H3 (H3K4). In this study, we further investigated histone methylation in MDR1 regulation and function. We show that the mixed lineage leukemia 1 (MLL1) protein, a histone methyltransferase specific for H3K4, is required for MDR1 promoter methylation, as knockdown of MLL1 resulted in a decrease in MDR1 expression. The regulation of MDR1 by MLL1 has functional consequences in that downregulation of MLL1 led to increased retention of the Pgp-specific substrate DIOC(2)(3), as well as increased cellular sensitivity to several Pgp substrates. Regulation of MDR1 by MLL1 was dependent on the CCAAT box within the proximal MDR1 promoter, similar to what we had shown for MDR1 promoter acetylation, and also requires NF-Y. Finally, overexpression of the most prevalent MLL fusion protein, MLL-AF4, led to increased MDR1 expression. This is the first identification of a histone methyltransferase and its leukemogenic rearrangement that regulates expression of an ABC drug transporter, suggesting a new target for circumvention of tumor multidrug resistance.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}513{"query": "Andrew Gay (born 5 October 1989 in Central Coast, New South Wales, Australia) is a rugby league player for Wales and for the South Wales Scorpions in the Championship One.", "pos": "Dele Adeleye and Sani Kaita- through a statement on their official website, FC Tavria, Dele Adeleye, in the Nigeria squad for two live-wire games against Madagascar on Sunday, comes from Donetsk Metallurg, where he scored three goals in 26 appearances from central defense.", "neg": "Milan Sablik (Czech pronunciation: (mlan sablik); Zdar nad Sazavou, 14 March 1991) is a Czech speedskater and the younger brother of Martina Sablikova, the 2007 European Champion and double World Single Distances Champion.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}514{"query": "Do's and Don'ts in Whale Watching The Department of Fisheries and Oceans has developed guidelines for whale watching in Johnstone Strait,where killer whales are found on a daily basis each summer. It is strongly recommended that vessel operators follow these guidelines for all kinds of whales. * Approach whales from the side, not from the front or the back. * Approach no closer than 100 metres, then stop the boat but keep the engine on. * Keep noise levels down-no horns, whistles or racing of engines. * Start your boat only after the whales are more than 100 metres from your vessel. * Leave the area slowly, gradually moving faster when you are more than 300 metres from the whales. * Approach and leave slowly, avoiding sudden changes in speed or direction. * Avoid disturbing groups of resting whales. * Keep at low speeds and remain in the same direction if travelling side by side with whales. * When whales are travelling close to shore, avoid crowding them near the shore or coming between the whales and the shore. * Limit the time spent with any group of whales to less than 30 minutes at a time when within 100 to 200 metres of whales. * If there is more than one vessel at the same observation spot, be sure to avoid any boat position that would result in surrounding the whales. * Work together by communicating with other vessels, and make sure that all operators are aware of the whale watching guidelines.", "pos": "Terra-cotta Warriors As the greatest archaeological findings of the 20th century, Terra-cotta Warriors has a really long history.In 246 BC, Qin Shi Huang, later the first Emperor of all China, had begun to prepare for his mausoleum which took 11 years to finish to defend him in the afterlife.There are over 7,000 pottery soldiers, horses, bronze chariots, and even weapons found in it now.Terra-cotta Warriors was listed by UNESCO in 1987 as one of the world cultural heritages and it has made Xi'an a famous city for tourists. Big Wild Goose Pagoda The Big Wild Goose Pagoda has a history of over 1,300 years and is a typical ancient Chinese building.It is located in the south of Xi'an City.Because Master Xuanzang stored his classics brought from India in the pagoda, it is also a holy place for Buddhists.As a National Key Cultural Relic Preserve, it won the title of an AAAA Tourist Attraction as well. Xi'an Ancient City Wall As one of the landmarks of Xi'an, Ancient City Wall still stretches round the old city today, dividing the city into the inner part and the outer part.Ancient City Wall was originally built during the old Tang Dynasty (618 -- 907) and then enlarged by Zhu Yuanzhang, Emperor of the Ming Dynasty, thus forming the modern Xi'an City Wall.After the extension, the wall now stands 12 meters tall, 12-14 meters wide at the top and 15-18 meters thick at the bottom.", "neg": "Swimming in the water of Hawaii's Big Island is a fun experience. But it can be more exciting if there are dolphins swimming around and jumping out of the sea too. For many people, it would be a wonderful dream to swim with these lovely animals! However, this may not be good for dolphins. They may get hurt because of human interaction . Dolphins are active and usually look for food at night. In the day, they like to rest in shallow bays . Many people think the dolphins are awake during the day as they swim. But when they sleep they rest half of their brain and keep the other half awake to breathe, so they may be sleeping even when they're swimming in the water. From 2010 to 2013, spinner dolphins of Hawaii's Big Island were exposed to human activities more than 82 percent of the time, according to Julian Tyne, a researcher at Australia's Murdoch University. The National Oceanic and Atmospheric Administration (NOAA) says disturbing the animals in their near-shore habitat could force them to swim to less favorable places, putting them at risk of attack by sharks and other animals. Besides, when people are around, dolphins become more active. Thus, they can't get enough sleep. \"Disturbing their resting behaviors can actually affect their long term health and the health of the dolphin population,\" Ann Garrett of NOAA's National Marine Fisheries Service told the Associated Press. As a result, the NOAA wants to make rules to help protect the dolphins. For example, the agency may ban swimming with the Hawaii spinner dolphins. Or they may stop people from swimming in shallow bays when the dolphins are resting. Tour operators must also be taught to watch for signs to know when the dolphins are in their resting state.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}515{"query": "Rachel (Andrea Bowen), a high school girl, seems to have the life that most people envy: she has a steady boyfriend, some great friends, and a place on the school's soccer team. Preparing for college and separating from her boyfriend are the main worries of this teen, as she lives a carefree life like most girls her age. However, Rachel's world falls apart the day she discovers that Jason (Eric von Detton), a former sexual partner of hers that died an untimely death, was in fact HIV positive and an IV drug user. She immediately goes to an AIDS clinic to get a rapid test, which unfortunately comes back positive. Devastated by the fact that she may actually be infected with the virus, Rachel then confides in her substitute teacher, Sarah (Jennie Garth), who has secretly been living with the disease for years. But both young women are about to find out their secrets will not be kept secret for very long, as word begins to spread throughout their high school and rumors fly, making some of these students realize that they may not be as \"clean\" as they think they are.", "pos": "At the Kibbutz Stein in Israel in 1956, school teacher Rachel (Clarice van Houten) is reunited with Ronnie (Halina Reijn), a friend from The Hague during World War II. After Ronnie leaves, Rachel reflects on her adventures during the final days of the war.In 1944, Rachel hides from the Nazis in a farm in the Dutch countryside. In exchange for hiding her, they expect her to learn Bible verses. One day, a crippled Allied bomber drops its payload on the farmhouse, killing everyone except Rachel. Rob (Michiel Heisman), a young man from a neighboring farm, hides her in the family's greenhouse. That night, Van Gein (Peter Blok), a police officer, arrives to tell them that the Nazis know that Rachel is in the area and will hunt her down. He agrees to help Rachel and Rob escape to the Allied controlled southern part of Holland. Rachel visits her father's lawyer, Smaal (Dolf de Vries). He gives her enough money and jewels to live on for a year but warns her not to trust people so easily. Van Gein leads Rachel and Rob to a dock where other Jews wait to leave. Rachel is reunited with her parents and brother, who is recovering from an emergency appendectomy. Van Gein does not accompany the Jews on the boat trip. That evening, the boat is ambushed by a Nazi patrol boat. The Nazis immediately open fire; only Rachel survives the massacre. Before drifting down the river, she sees the Nazis loot the corpses.Rachel is found by Resistance fighters who smuggle her into The Hague by disguising her as a typhoid victim and placing her in a coffin that if properly \"sealed\" has sizable air holes. She is taken to a soup kitchen run by another member of the Resistance, Gerben Kuipers (Derek de Lint) and given the new name of Ellis de Vries. Eventually she is made a part of the Resistance's plans to smuggle in British guns and rations. The smugglers are led by Hans Akkermans (Thom Hoffman), an expert marksman. He and Ellis are to pose as husband and wife so the Nazis will not search their luggage on the train; the luggage is actually full of weaponry. But when the Nazi soldiers on the train clearly do intend to search all baggage, a new plan is needed. Ellis takes the bags and enters a private compartment occupied by SD Colonel Muntze (Sebastian Koch). The Nazis don't search Muntze's compartment. Ellis and Muntze are clearly attracted to each other and she accepts an offer to visit him at his office. Hans is clearly jealous.A truck carrying the British guns crashes in front of the soup kitchen. Kuiper's son, Tim (Ronald Armbrust) was driving and is arrested by the Gestapo. While the others go into hiding, Ellis arranges a meeting with Muntze hoping that she can persuade him to release Tim. Knowing he is an avid stamp collector, she takes some rare Dutch stamps to him. He invites her to a Nazi party. There she sees SS commandant Gunter Franken (Waldemar Kobus) and recognizes him as the Nazi who led the ambush against the refugee boat. Although she is sickened at his sight, she manages to sing at the party later. She and Muntze return to his suite to make love. He intuits that she is Jewish from her dyed blond hair but has fallen in love with her. She accepts a job in his office and begins work the following day. There she meets Ronnie, who is Franken's secretary/sex partner. Franken gives them a report indicating that Tim has confessed everything and is to be executed, however, Muntze refuses to sign the execution order.Ellis sees Smaal at Nazi headquarters and learns that he and Muntze have negotiated a cease fire -- if the Resistance ceases its attacks against the Nazis, the Nazis will cease its violent reprisals against Dutch civilians. However, when a hidden microphone placed by Ellis in Franken's office reveals that Franken and Van Gein have been working together to kill and rob Jews trying to escape into Allied territory, a controversy amongst the Resistance fighters ensues. Van Gein is heard", "neg": "Jonathan Shale (Berenger) is a mercenary and a Vietnam veteran who returns home to Miami after a botched covert operation in Cuba in which three men from his platoon were killed. He surprises his girlfriend, Jane Hetzko (Diane Venora) at her apartment and is warmly welcomed. On the outside, Jane is a schoolteacher at inner-city Columbus High School, an institution with a considerable gang problem. She is particularly disliked by Juan Lacas (Anthony), leader of the KOD (\"Kings of Destruction\") gang. While jogging one morning, Jane is attacked and has her leg broken. Jane and Shale believe this to be related to the KOD, which prompts the latter to go undercover as an Ivy League-educated, government-affiliated substitute teacher for his girlfriend's class. Shale arrives at Columbus High School and is, at first, taken back by the lowly conditions. He is unable to control his class of poorly-educated students on the first day, but decides to use his street-smarts and military tactics to gain the upper hand. Soon enough, he is able to take command of the students by displaying his combat self-defence techniques when students attack him. He is warned not to use such methods by Principal Claude Rolle (Hudson), but gains the respect of his students when he bonds with them over the similarities between his early gang and Vietnam War experiences and their involvement in petty crime and street gangs. During this time, he befriends fellow schoolteacher Darrell Sherman (Plummer) and also crosses paths with Lacas, one of his students. Suspicious of odd conditions within the high school, Shale sets up surveillance cameras throughout the building. He discovers that Lacas orchestrated the attack on Jane. He also discovers that Lacas is secretly working with Rolle to distribute cocaine around Miami for a major narcotics ring. Shale and his team raid a drug deal, using the stolen money to buy music and sports equipment in the form of a \"school donation.\" While Sherman initially denies Shale's discovery, Sherman and a female student inadvertently witness the drugs being loaded into one of the school buses later that day. Sherman tells the student to warn Shale and Hetzko, and sacrifices himself by creating a distraction. Rolle, who at this point is aware of Shale's interference orders a \"car accident\" for Shale, and sends Lacas after Hetzko. With the help of another student, Lacas is killed and Shale saves Hetzko, learning the full story from the female witness. Shale and his team garrison the school grounds to enter combat against the remaining K.O.D. members, a rival mercenary company led by Janus, and Rolle himself. Ultimately, Shale and Joey Six end up as the sole survivors of the battle, walking away from the school grounds discussing future operations as substitute teachers.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}516{"query": "Modeled after US hot website.com, group buying websites are now popular in China. These websites use the power of group buying to get competitive discounts for a daily deal on some best stuff to do, see, eat and buy in the cities across China. Discounts are available within just one click. Zhao lei, a software engineer in Beijing, loves the one-hour lunch break at noon,as it is the best time for him to check \"today's special\" at his favorite group buying websites . Sometimes he searches for great deals at directory sites devoted to the new shopping space. Zhao spends around 800 yuan($117.65) on group buying every month, mostly to buy food coupons for eating at some nice restaurants and occasionally to find something fun to do. \" I love group buying. In addition to the competitive discounts it offers, it helps me get something fun, exciting and new, and such surprises give me a reason to try something new,\" he said. When he finds a really good bargain, he will send the link to friends or colleagues through MSN,QQ, or e-mail, or share the information at some social networking websites. In doing so, he often gets a certain cut off the price. At some sites, buyers are invited to leave notes about what they want to buy and the website will consider it if similar applications reach a certain number. That is how Zuo got her digital camera after waiting for two months. \"It is cool. I want to buy a new digitgal camera for my trip to Switzerland this winter, but I never expected such cheap prices!\" Zuo said.", "pos": "Have you ever been to the world's smallest bookstore? The World's Smallest Bookstore,whose official name is just these three words,sits quietly about 100 miles northeast of Toronto. The bookstore is about 10 feet by 10 feet,so it is easy to imagine how tiny it really is.The bookstore is open 24 hours a day.Inside the bookstore are various books,especially literary books and classic authors' works.So if you are looking for something less popular,you may get a bit disappointed there. Another special feature of this bookstore is that each book only costs three dollars.All the expenses are paid on the honor system,which means buyers should make a note of what they've bought and leave their money by themselves.So the tools of the trade in this bookstore are quite simple: pens,papers,light bulbs and a label-maker. In order to catch passers-by's attention,the billboards of the bookstore are several times bigger than the store itself.With these large eye-catchers,many people are willing to stop by and have a visit.", "neg": "Top 5 Must See Places in Beijing Beijing is an old capital city with a lot of tourists attractions. What is the most representative place in Beijing? The answers are various. Here are the Top 5 Must See Places in Beijing. 1. Forbidden City The Forbidden City is the ideal place for you to begin your exploration of Beijing. Make sure to wear comfortable shoes as you have to walk a lot! A multilingual guide recorder is recommended, as it can tell you the stories behind the palace. Opening Hour: 8:30-17:00 Entrance Fee: RMB 60 2. Tian'anmen Square Lying in the heart of Beijing City, it is the place for massive parades and gathering. It boasts of the largest square of such kind in the world. At sunrise and sunset the raising and lowering ceremony of the Chinese National Flag is well worth seeing. Ticket fees: Free Opening Time: Whole Day 3. Great Wall Most of the sections of the Great Wall in Beijing are well-preserved, and the most famous section is Badaling. For the Great Wall hiking, get ready for strong footwear. For hot weather, please also prepare sunblock, sunglasses and water. Badaling Great Wall: Ticket Fees: RMB40 (Nov. 01 to Mar. 31); RMB 45 (Apr. 01 to Oct. 31) Open Hours: 6:40 to 18:30 4. Summer Palace Regarded as the largest imperial garden in China, the Summer Palace is in fact a park-styled royal retreat. With masterly design and artistic architecture integrating the highlight of Chinese garden arts, it has earned a title of \"Royal Garden Museum\". Open Time: 6:30-20:30 Ticket Fee: RMB 40 (low season) / RMB 50 (peak season during the holidays) 5. Temple of Heaven The Temple of Heaven worked as sacrificial compound buildings for the Ming and Qing emperors. What's the intriguing by-production of the temple is that if you enter the Temple of Heaven in the early morning, you can find many people doing all types of Kungfu, Taiji, dancing and other morning exercises. Open Time: 6:00-21:00 Ticket Fee: RMB 35", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}517{"query": "Chronic myeloid leukemia (CML) is the first human malignancy for which the promise of targeted therapy has come true. CML is invariably associated with a specific genetic lesion--the t(9;22) chromosomal translocation. As a consequence of this translocation, a BCR-ABL fusion gene is formed on the 22q- derivative (traditionally known as the Philadelphia chromosome) and the deregulated tyrosine kinase activity of the protein encoded by this gene has been shown to be both necessary and sufficient for initiation and maintenance of the disease. Imatinib mesylate, an orally available tyrosine kinase inhibitor that targets Bcr-Abl, entered clinical evaluation in 1998. Its efficacy surpassed almost everyone's predictions, and the observation of high response rates and favorable toxicity profile associated with imatinib therapy led to its approval as first-line treatment for all newly diagnosed CML patients over an exceptionally short period of time. The 6-year results of the Phase III trial have recently been reported and confirm durability of responses and declining incidence of adverse events over time, although, at present, occurrence of unexpected side effects in the long term cannot be excluded. Although imatinib does not 'cure' CML and has to be administered chronically to patients, it has revolutionized both outcome and quality of life of CML patients.", "pos": "Chronic myeloid leukemia (CML) is characterized by the Philadelphia translocation that fuses BCR sequences from chromosome 22 upstream of the ABL gene on chromosome 9. The chimerical Bcr-Abl protein expressed by CML cells has constitutive tyrosine kinase activity, which is essential for the pathogenesis of the disease. Imatinib, an ATP-competitive selective inhibitor of Bcr-Abl, has unprecedented efficacy for the treatment of CML. Most patients with early stage disease achieve durable complete hematological and complete cytogenetic remissions, with minimal toxicity. In contrast, responses are less stable in patients with advanced CML. This review highlights the pathogenesis of CML, its clinical features, and the development of imatinib as a specific molecularly targeted therapy. Aspects of disease monitoring and side effects are covered as well as resistance to imatinib and strategies to overcome resistance, such as alternative signal transduction inhibitors and drug combinations. Perspectives for further development are also discussed.", "neg": "Cell-mediated immunity plays a crucial role in the control of many infectious diseases, necessitating the need for adjuvants that can augment cellular immune responses elicited by vaccines. It is well established that protection against one such disease, malaria, requires strong CD8(+) T cell responses targeted against the liver stages of the causative agent, Plasmodium spp. In this report we show that the dendritic cell-specific chemokine, dendritic cell-derived CC chemokine 1 (DC-CK1), which is produced in humans and acts on naive lymphocytes, can enhance Ag-specific CD8(+) T cell responses when coadministered with either irradiated Plasmodium yoelii sporozoites or a recombinant adenovirus expressing the P. yoelii circumsporozoite protein in mice. We further show that these enhanced T cell responses result in increased protection to malaria in immunized mice challenged with live P. yoelii sporozoites, revealing an adjuvant activity for DC-CK1. DC-CK1 appears to act preferentially on naive mouse lymphocytes, and its adjuvant effect requires IL-12, but not IFN-gamma or CD40. Overall, our results show for the first time an in vivo role for DC-CK1 in the establishment of primary T cell responses and indicate the potential of this chemokine as an adjuvant for vaccines against malaria as well as other diseases in which cellular immune responses are important.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}518{"query": "Remember that H2 O is a polar molecule, so it can dissolve many substances (Figure 1.1). Salts, sugars, acids, bases, and organic molecules can all dissolve in water. Where does the salt in seawater come from? As water moves through rock and soil on land it picks up ions. This is the flip side of weathering. Salts comprise about 3.5% of the mass of ocean water, but the salt content, or salinity, is different in different locations. What would the salinity be like in an estuary? Where seawater mixes with fresh water, salinity is lower than average. What would the salinity be like where there is lots of evaporation? Where there is lots of evaporation but little circulation of water, salinity can be much higher. The Dead Sea has 30% salinity nearly nine times the average salinity of ocean water (Figure 1.2). Why do you think this water body is called the Dead Sea? In some areas, dense saltwater and less dense freshwater mix, and they form an immiscible layer, just like oil and water. One such place is a \"cenote\", or underground cave, very common in certain parts of Central America. Ocean water is composed of many sub- stances, many of them salts such as sodium, magnesium, and calcium chlo- ride. Because of the increased salinity, the wa- ter in the Dead Sea is very dense, it has such high salinity that people can easily float in it! With so many dissolved substances mixed in seawater, what is the density (mass per volume) of seawater relative to fresh water? Water density increases as: salinity increases temperature decreases pressure increases Differences in water density are responsible for deep ocean currents, as will be discussed in the \"Deep Ocean Currents\" concept. Click image to the left or use the URL below. URL:", "pos": "Freshwater below Earths surface is called groundwater. The water infiltrates, or seeps down into, the ground from the surface. How does this happen? And where does the water go? Water infiltrates the ground because soil and rock are porous. Between the grains are pores, or tiny holes. Since water can move through this rock it is permeable. Eventually, the water reaches a layer of rock that is not porous and so is impermeable. Water stops moving downward when it reaches this layer of rock. Look at the diagram in Figure 13.11. It shows two layers of porous rock. The top layer is not saturated; it is not full of water. The next layer is saturated. The water in this layer has nowhere else to go. It cannot seep any deeper into the ground because the rock below it is impermeable. The top of the saturated rock layer in Figure 13.11 is called the water table. The water table isnt like a real table. It doesnt remain firmly in one place. Instead, it rises or falls, depending on how much water seeps down from the surface. The water table is higher when there is a lot of rain and lower when the weather is dry. An underground layer of rock that is saturated with groundwater is called an aquifer. A diagram of an aquifer is shown in Figure 13.12. Aquifers are generally found in porous rock, such as sandstone. Water infiltrates the aquifer from the surface. The water that enters the aquifer is called recharge. Most land areas have aquifers beneath them. Many aquifers are used by people for freshwater. The closer to the surface an aquifer is, the easier it is to get the water. However, an aquifer close to the surface is also more likely to become polluted. Pollutants can seep down through porous rock in recharge water. An aquifer that is used by people may not be recharged as quickly as its water is removed. The water table may lower and the aquifer may even run dry. If this happens, the ground above the aquifer may sink. This is likely to damage any homes or other structures built above the aquifer. One of the biggest aquifers in the world is the Ogallala aquifer. As you can see from Figure 13.13, this aquifer lies beneath parts of eight U.S. states. It covers a total area of 451,000 square kilometers (174,000 square miles). In some places, it is less than a meter deep. In other places, it is hundreds of meters deep. The Ogallala aquifer is an important source of freshwater in the American Midwest. This is a major farming area, and much of the water is used to irrigate crops. The water in this aquifer is being used up ten times faster than it is recharged. If this continues, what might happen to the Ogallala aquifer? The top of an aquifer may be high enough in some places to meet the surface of the ground. This often happens on a slope. The water flows out of the ground and creates a spring. A spring may be just a tiny trickle, or it may be a big gush of water. One of the largest springs in the world is Big Spring in Missouri, seen in Figure 13.14. Water flowing out of the ground at a spring may flow downhill and enter a stream. Thats what happens to the water that flows out of Big Spring in Missouri. If the water from a spring cant flow downhill, it may spread out to form a pond or lake instead. Lake George in New York State, which is pictured in Figure 13.15, is a spring-fed lake. The lake basin was carved by a glacier. Some springs have water that contains minerals. Groundwater dissolves minerals out of the rock as it seeps through the pores. The water in some springs is hot because it is heated by hot magma. Many hot springs are also mineral springs. Thats because hot water can dissolve more minerals than cold water. Grand Prismatic Spring, shown in Figure 13.16, is a hot mineral spring. Dissolved minerals give its water a bright blue color. The edge of the spring is", "neg": "Most sedimentary rocks form from sediments. Sediments are small pieces of other rocks, like pebbles, sand, silt, and clay. Sedimentary rocks may include fossils. Fossils are materials left behind by once-living organisms. Fossils can be pieces of the organism, like bones. They can also be traces of the organism, like footprints. Most often, sediments settle out of water (Figure 4.13). For example, rivers carry lots of sediment. Where the water slows, it dumps these sediments along its banks, into lakes and the ocean. When sediments settle out of water, they form horizontal layers. A layer of sediment is deposited. Then the next layer is deposited on top of that layer. So each layer in a sedimentary rock is younger than the layer under it. It is older than the layer over it. Sediments are deposited in many different types of environments. Beaches and deserts collect large deposits of sand. Sediments also continuously wind up at the bottom of the ocean and in lakes, ponds, rivers, marshes, and swamps. Avalanches produce large piles of sediment. The environment where the sediments are deposited determines the type of sedimentary rock that can form. Sedimentary rocks form in two ways. Particles may be cemented together. Chemicals may precipitate. Over time, deposited sediments may harden into rock. First, the sediments are compacted. That is, they are squeezed together by the weight of sediments on top of them. Next, the sediments are cemented together. Minerals fill in the spaces between the loose sediment particles. These cementing minerals come from the water that moves through the sediments. These types of sedimentary rocks are called clastic rocks. Clastic rocks are rock fragments that are compacted and cemented together. Clastic sedimentary rocks are grouped by the size of the sediment they contain. Conglomerate and breccia are made of individual stones that have been cemented together. In conglomerate, the stones are rounded. In breccia, the stones are angular. Sandstone is made of sand-sized particles. Siltstone is made of smaller particles. Silt is smaller than sand but larger than clay. Shale has the smallest grain size. Shale is made mostly of clay-sized particles and hardened mud. Chemical sedimentary rocks form when crystals precipitate out from a liquid. The mineral halite, also called rock salt, forms this way. You can make halite! Leave a shallow dish of salt water out in the Sun. As the water evaporates, salt crystals form in the dish. There are other chemical sedimentary rocks, like gypsum. Table 4.1 shows some common types of sedimentary rocks and the types of sediments that make them up. Picture Rock Name Conglomerate Type of Sedimentary Rock Clastic Breccia Clastic Sandstone Clastic Siltstone Clastic Limestone Bioclastic Coal Organic Picture Rock Name Rock Salt Type of Sedimentary Rock Chemical precipitate", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}519{"query": "The Ghost Dance War was an armed conflict in the United States between the Lakota Sioux and the United States government from 1890 until 1891.", "pos": "The Siege of Paysandu began 3 December 1864, during the Uruguayan War, when Brazilian forces (under Marquis of Tamandare) and Colorado forces (under Venancio Flores) attempted to capture the city of Paysandu in Uruguay from its Uruguayan Army defenders.", "neg": "Albino Perez (died 8 August 1837) was a Mexican soldier and politician who was appointed Governor of New Mexico.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}520{"query": "Selenium, an essential trace element, is incorporated into selenoproteins as selenocysteine (Sec), the 21st amino acid. In order to synthesize selenoproteins, a translational reprogramming event must occur since Sec is encoded by the UGA stop codon. In mammals, the recoding of UGA as Sec depends on the selenocysteine insertion sequence (SECIS) element, a stem-loop structure in the 3' untranslated region of the transcript. The SECIS acts as a platform for RNA-binding proteins, which mediate or regulate the recoding mechanism. Using UV crosslinking, we identified a 110 kDa protein, which binds with high affinity to SECIS elements from a subset of selenoprotein mRNAs. The crosslinking activity was purified by RNA affinity chromatography and identified as nucleolin by mass spectrometry analysis. In vitro binding assays showed that purified nucleolin discriminates among SECIS elements in the absence of other factors. Based on siRNA experiments, nucleolin is required for the optimal expression of certain selenoproteins. There was a good correlation between the affinity of nucleolin for a SECIS and its effect on selenoprotein expression. As selenoprotein transcript levels and localization did not change in siRNA-treated cells, our results suggest that nucleolin selectively enhances the expression of a subset of selenoproteins at the translational level.", "pos": "The amino acid selenocysteine is encoded by UGA, usually a stop codon, thus requiring a specialized machinery to enable its incorporation into selenoproteins. The machinery comprises the tRNA(Sec), a 3'-UTR mRNA stem-loop termed SElenoCysteine Insertion Sequence (SECIS), which is mandatory for recoding UGA as a Sec codon, the SECIS Binding Protein 2 (SBP2), and other proteins. Little is known about the molecular mechanism and, in particular, when, where, and how the SECIS and SBP2 contact the ribosome. Previous work by others used the isolated SECIS RNA to address this question. Here, we developed a novel approach using instead engineered minimal selenoprotein mRNAs containing SECIS elements derivatized with photoreactive groups. By cross-linking experiments in rabbit reticulocyte lysate, new information could be gained about the SBP2 and SECIS contacts with components of the translation machinery at various translation steps. In particular, we found that SBP2 was bound only to the SECIS in 48S pre-initiation and 80S pretranslocation complexes. In the complex where the Sec-tRNA(Sec) was accommodated to the A site but transpeptidation was blocked, SBP2 bound the ribosome and possibly the SECIS element as well, and the SECIS had flexible contacts with the 60S ribosomal subunit involving several ribosomal proteins. Altogether, our findings led to broadening our understanding about the unique mechanism of selenocysteine incorporation in mammals.", "neg": "Cis-regulatory modules are non-protein-coding regions of DNA essential for the control of gene expression. One class of regulatory modules is embryonic enhancers, which drive gene expression during development as a result of transcription factor protein binding at the enhancer sequences. Recent comparative studies have begun to investigate the evolution of the sequence architecture within enhancers. These analyses are illuminating the way that developmental biologists think about enhancers by revealing their molecular mechanism of function.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}521{"query": "In physics, resistance is opposition to the flow of electric charges in an electric current as it travels through matter. The SI unit for resistance is the ohm. Resistance occurs because moving electrons in current bump into atoms of matter. Resistance reduces the amount of electrical energy that is transferred through matter. Thats because some of the electrical energy is absorbed by the atoms and changed to other forms of energy, such as heat. Q: In the rugby analogy to resistance in physics, what do the players on each team represent? A: The player on the blue and black team represents a moving electron in an electric current. The players on the red and blue team represent particles of matter through which the current is flowing. How much resistance a material has depends on several factors: the type of material, its width, its length, and its temperature. All materials have some resistance, but certain materials resist the flow of electric current more or less than other materials do. Materials such as plastics have high resistance to electric current. They are called electric insulators. Materials such as metals have low resistance to electric current. They are called electric conductors. A wide wire has less resistance than a narrow wire of the same material. Electricity flowing through a wire is like water flowing through a hose. More water can flow through a wide hose than a narrow hose. In a similar way, more current can flow through a wide wire than a narrow wire. A longer wire has more resistance than a shorter wire. Current must travel farther through a longer wire, so there are more chances for it to collide with particles of matter. A cooler wire has less resistance than a warmer wire. Cooler particles have less kinetic energy, so they move more slowly. Therefore, they are less likely to collide with moving electrons in current. Materials called superconductors have virtually no resistance when they are cooled to extremely low temperatures. Resistance can be helpful or just a drain on electrical energy. If the aim is to transmit electric current through a wire from one place to another, then resistance is a drawback. It reduces the amount of electrical energy that is transmitted because some of the current is absorbed by particles of matter. On the other hand, if the aim is to use electricity to produce heat or light, then resistance is useful. When particles of matter absorb electrical energy, they change it to heat or light. For example, when electric current flows through the tungsten wire inside an incandescent light bulb like the one in the Figure 1.1, the tungsten resists the flow of electric charge. It absorbs electrical energy and converts some of it to light and heat. Q: The tungsten wire inside a light bulb is extremely thin. How does this help it do its job? A: The extremely thin wire has more resistance than a wider wire would. This helps the wire resist electric current and change it to light.", "pos": "For electric current to flow through a wire, there must be a source of voltage. Voltage is a difference in electric potential energy. As you might have guessed, greater voltage results in more current. As electric current flows through matter, particles of matter resist the moving charges. This is called resistance, and greater resistance results in less current. These relationships between electric current, voltage, and resistance were first demonstrated in the early 1800s by a German scientist named Georg Ohm, so they are referred to as Ohms law. Ohms law can be represented by the following equation. Current(amps) = Voltage(volts) Resistance(ohms) Ohms law may be easier to understand with an analogy. Current flowing through a wire is like water flowing through a hose. Increasing voltage with a higher-volt battery increases the current. This is like opening the tap wider so more water flows through the hose. Increasing resistance reduces the current. This is like stepping on the hose so less water can flow through it. You can use the equation for current (above) to calculate the amount of current flowing through a circuit when the voltage and resistance are known. Consider an electric wire that is connected to a 12-volt battery. If the wire has a resistance of 2 ohms, how much current is flowing through the wire? Current = 12 volts 2 ohms = 6 amps Q: If a 120-volt voltage source is connected to a wire with 10 ohms of resistance, how much current is flowing through the wire? A: Substitute these values into the equation for current: Current = 120 volts 10 ohms = 12 amps", "neg": "Coming off their divisional road win over the Dolphins, the Jets flew to Ralph Wilson Stadium for a Week 4 AFC East duel with the throwback-clad Buffalo Bills. New York scored in the first quarter as running back LaDainian Tomlinson got a 1-yard touchdown run. The Jets added onto their lead in the second quarter with a 19-yard field goal from kicker Nick Folk, followed by quarterback Mark Sanchez completing a 41-yard touchdown pass to wide receiver Braylon Edwards. The Bills closed out the half with quarterback Ryan Fitzpatrick finding tight end David Martin on a 4-yard touchdown pass. New York pulled away in the third quarter as tight end Dustin Keller caught a 3-yard touchdown pass from wide receiver/quarterback Brad Smith, followed by his 2-yard touchdown reception thrown by Sanchez. Afterwards, Tomlinson's 26-yard touchdown run effectively secured the victory. Buffalo closed out the game in the fourth quarter as Fitzpatrick threw a touchdown pass to wide receiver Steve Johnson.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}522{"query": "Esra Erol (6 November 1985) is a Turkish female footballer currently playing in the Turkish First League in defender position for Kirecburnu Spor in Istanbul.", "pos": "Tugrul Erat (born 17 June 1992) is an Azerbaijani footballer who plays as a midfielder for Fortuna Dusseldorf.", "neg": "Yeliz Fndk (born in 1976) is a Turkish female martial artist competing in the Taekwondo, boxing, Muay Thai, Kickboxing and wushu discipilines.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}523{"query": "Chronic myeloid leukemia (CML) is a myeloproliferative disease characterized by the overproduction of granulocytes, which leads to high white blood cell counts and splenomegaly in patients. Based on clinical symptoms and laboratory findings, CML is classified into three clinical phases, often starting with a chronic phase, progressing to an accelerated phase and ultimately ending in a terminal phase called blast crisis. Blast crisis phase of CML is clinically similar to an acute leukemia; in particular, B-cell acute lymphoblastic leukemia (B-ALL) is a severe form of acute leukemia in blast crisis, and there is no effective therapy for it yet. CML is induced by the BCR-ABL oncogene, whose gene product is a BCR-ABL tyrosine kinase. Currently, inhibition of BCR-ABL kinase activity by its kinase inhibitor such as imatinib mesylate (Gleevec) is a major therapeutic strategy for CML. However, the inability of BCR-ABL kinase inhibitors to completely kill leukemia stem cells (LSCs) indicates that these kinase inhibitors are unlikely to cure CML. In addition, drug resistance due to the development of BCRABL mutations occurs before and during treatment of CML with kinase inhibitors. A critical issue to resolve this problem is to fully understand the biology of LSCs, and to identify key genes that play significant roles in survival and self-renewal of LSCs. In this review, we will focus on LSCs in CML by summarizing and discussing available experimental results, including the original studies from our own laboratory.", "pos": "Chronic myeloid leukemia (CML) arises as a consequence of a chromosomal translocation giving rise to the Philadelphia chromosome and Bcr-Abl oncogene. CML is a clonal disease of stem cell origin and an excellent example of a malignancy in which tumor-initiating cells may hold the key to disease eradication. The known molecular basis of CML has enabled the development of Abl-specific tyrosine kinase inhibitors, such as imatinib mesylate. However, the success of tyrosine kinase inhibitors, as rationally designed first-line therapies, has been tempered by problems of disease persistence and resistance. Residual disease has been shown to be enriched within the stem cell compartment and to persist at stable levels for up to 5 years of complete cytogenetic response. This finding has led to further searches for novel strategies aimed at eliminating these cells; such strategies may be essential in achieving cure. The most significant recent findings are discussed in this review.", "neg": "Heme is critical for a variety of cellular processes, but excess intracellular heme may result in oxidative stress and membrane injury. Feline leukemia virus subgroup C receptor (FLVCR1), a member of the SLC49 family of four paralogous genes, is a cell surface heme exporter, essential for erythropoiesis and systemic iron homeostasis. Disruption of FLVCR1 function blocks development of erythroid progenitors, likely due to heme toxicity. Mutations of SLC49A1 encoding FLVCR1 are noted in patients with a rare neurodegenerative disorder: posterior column ataxia with retinitis pigmentosa. FLVCR2 is highly homologous to FLVCR1 and may function as a cellular heme importer. Mutations of SLC49A2 encoding FLVCR2 are observed in Fowler syndrome, a rare proliferative vascular disorder of the brain. The functions of the remaining members of the SLC49 family, MFSD7 and DIRC2 (encoded by the SLC49A3 and SLC49A4 genes), are unknown, although the latter is implicated in hereditary renal carcinomas. SLC48A1 (heme responsive gene-1, HRG-1), the sole member of the SLC48 family, is associated with the endosome and appears to transport heme from the endosome into the cytosol.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}524{"query": "A mutation in the ubiquilin 2 gene (UBQLN2) was recently identified as a cause of X-linked amyotrophic lateral sclerosis (ALS)/frontotemporal dementia (FTD) and a major component of the inclusion bodies commonly found with a wide variety of ALS. ALS-linked mutations in UBQLN2 are clustered in a unique proline-X-X repeat region, reportedly leading to impairment of the ubiquitin proteasome system. However, the molecular properties of mutant UBQLN2 remain unclear. To gain insight into the pathogenesis of UBQLN2-linked ALS/FTD, we examined the biochemical and cellular characteristics of mutant UBQLN2 in vitro. UBQLN2 localized in Rab11-positive endosomal vesicles formed by the ALS-linked molecule optineurin (OPTN). These vesicles were ubiquitin- and p62-immunopositive and also co-localized with an initiator of the autophagic process, ULK1, after amino acid starvation. An ALS-linked mutation (E478G) in OPTN abolished vesicle formation. ALS-linked mutations in UBQLN2 additively enhanced UBQLN2 aggregation and formation of inclusion bodies, resulting in mislocation from OPTN vesicles. UBQLN2 was found to be a potent regulator of the levels of the FTD-linked secretory factor progranulin, possibly via the endosomal system, and ALS-linked mutations disturbed these functional consequences. This study demonstrates that ALS-linked mutations in both OPTN and UBQLN2 interfere with the constitution of specific endosomal vesicles, suggesting that the vesicles are involved in protein homeostasis and that these proteins function in common pathological processes. These data suggest a novel disease spectrum and provide new pathological insights into OPTN and UBQLN2, enhancing our understanding of the molecular basis of ALS/FTD.", "pos": "Missense mutations in ubiquilin 2 (UBQLN2) cause ALS with frontotemporal dementia (ALS-FTD). Animal models of ALS are useful for understanding the mechanisms of pathogenesis and for preclinical investigations. However, previous rodent models carrying UBQLN2 mutations failed to manifest any sign of motor neuron disease. Here, we show that lines of mice expressing either the ALS-FTD-linked P497S or P506T UBQLN2 mutations have cognitive deficits, shortened lifespans, and develop motor neuron disease, mimicking the human disease. Neuropathologic analysis of the mice with end-stage disease revealed the accumulation of ubiquitinated inclusions in the brain and spinal cord, astrocytosis, a reduction in the number of hippocampal neurons, and reduced staining of TAR-DNA binding protein 43 in the nucleus, with concomitant formation of ubiquitin", "neg": "ATP13A2 (PARK9) loss of function mutations are a genetic cause of an early-onset form of Parkinson's disease (PD), with in vitro studies showing that ATP13A2 deficits lead to lysosomal and mitochondrial dysfunction and -synuclein accumulation, while elevated ATP13A2 expression reduces -synuclein toxicity. The three human brain tissue studies assessing changes in ATP13A2 expression in PD produced divergent results; mRNA is increased while protein levels were observed to be either increased or decreased. This apparent conflict in protein levels might have arisen from examining Lewy body disease cases with coexisting Alzheimer-type pathologies.To assess whether ATP13A2 levels in Lewy body disease are modified by Alzheimer-type -amyloid deposition, we evaluated cases of pure PD and pure dementia with Lewy bodies (DLB) for changes in ATP13A2, -synuclein and -amyloid protein levels in cortical regions with and without Lewy bodies. In all Lewy body disease cases, we identified decreased ATP13A2 protein levels that correlated with increases in both -synuclein and -amyloid. Partial colocalization was observed between ATP13A2 and -synuclein in Lewy bodies, whereas ATP13A2 did not colocalize with pathological -amyloid deposition. Our data show that patients with Lewy body diseases have an overall deficit in ATP13A2 protein levels, with the remaining protein being more insoluble and partially redistributing towards Lewy bodies. This supports the concept that increasing ATP13A2 levels may offer potential therapeutic benefits to patients with Lewy body diseases.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}525{"query": "Born to Maharaja Sawai Man Singh II and his first wife, Marudhar Kanwar of Jodhpur, Bhawani Singh was educated at Sheshbagh School, Srinagar, The Doon School, Dehradun, and later Harrow School in the United Kingdom.", "pos": "Rahmat-un-Nisa (1620 -- October/November 1691), better known by her title Nawab Bai, was the second wife of the Mughal Emperor Aurangzeb.", "neg": "Born in Belfast, Northern Ireland, the son of Thomas Megahey (a minister) and Beatrice (nee Walton), Leslie Megahey was educated at King Edward VI School in Lichfield.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}526{"query": "The Three Little Wolves and the Big Bad Pig is a children's picture book written by Eugene Trivizas (Evgenios Trivizas), illustrated by Helen Oxenbury, and first published by Heinemann in 1993.", "pos": "The Story of Tracy Beaker is a British children's book first published in 1991, written by Jacqueline Wilson and illustrated by Nick Sharratt.", "neg": "In 1994, the Mexican magazine Somos published a list of ''The 100 best movies of the cinema of Mexico'' in its 100th edition and choose El compadre Mendoza the 3rd better of all time, just behind Vamonos con Pancho Villa and Los olvidados.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}527{"query": "Shaka Sankofa (born Gary Lee Graham) (September 5, 1963 -- June 22, 2000) was a Texas death-row inmate who was sentenced to death at the age of 18 for the murder of fifty-three-year-old Bobby Grant Lambert in Houston, Texas on May 13, 1981.", "pos": "Sajal Barui (Bengali: ) is a convicted criminal who is serving a life sentence in prison for the murder of his father, stepmother, and stepbrother.", "neg": "Two white racists, Billy Ray Cobb (Nicky Katt) and Pete Willard (Doug Hutchison), come across a 10-year-old black girl named Tonya Hailey (Rae'Ven Larrymore Kelly) in rural Mississippi. They violently rape and beat Tonya and dump her in a nearby river after a failed attempt to hang her. She survives, and the men are arrested.Tonya's father, Carl Lee Hailey (Samuel L. Jackson), seeks out Jake Brigance (Matthew McConaughey), an easygoing white lawyer. Carl Lee is worried that the men may be acquitted due to deep-seated racism in the Mississippi Delta area. They discuss a similar case further south in which four white teenagers were acquitted of the rape of a black girl. Brigance admits the possibility that the rapists will walk free in this case as well. Carl Lee acquires an M16 rifle, goes to the county courthouse and opens fire. This results in the deaths of both rapists and also in the unintended injury of Deputy Looney (Chris Cooper), who has to have his leg amputated. Carl Lee is soon arrested without resistance. Brigance agrees to provide defense for Carl Lee for a much smaller amount of money than such a trial would usually require. He intends to enter a plea of not guilty by reason of temporary insanity.The rape and subsequent revenge killing gain national media attention. The Ku Klux Klan begins to organize in the area. Freddie Lee Cobb (Kiefer Sutherland), the brother of Billy Ray, calls Brigance and his family with death threats and organizes the formation of a Klan chapter in the county. The district attorney, Rufus Buckley (Kevin Spacey), decides to seek the death penalty, and presiding Judge Omar Noose (Patrick McGoohan) denies Brigance a change of venue. Brigance seeks help for his defense team from sleazy divorce lawyer and close friend Harry Rex Vonner (Oliver Platt). He seeks guidance from long-time liberal activist Lucien Wilbanks (Donald Sutherland), a once-great civil rights lawyer who was disbarred for violence on a picket line.Brigance is approached by Ellen Roark (Sandra Bullock), a fiery liberal law student from Massachusetts who belongs to the ACLU. Brigance is initially reluctant to accept Ellen's cooperation, but he later agrees to let her help with the case. The trial begins amid much attention from the media and public. The Klan, which has a member inside the sheriff's department, burns a cross on Brigance's lawn. This incident causes an argument between Brigance and his wife to the effect that if Jake had heeded Carl Lee's warning, this would not have happened. The police evacuate Jake's family from their house. Brigance and the police capture one of the Klan members, and they find a case with a bomb inside it. Brigance throws the bomb into the air, where it explodes. This motivates Jake to send his wife and young daughter away while the trial continues.As the trial begins, the KKK march down Canton's streets and meet a large group of mostly black protesters at the courthouse. Chaos ensues outside the courthouse as the police lose control of the crowd. A black teenager kills the KKK Grand Dragon (Kurtwood Smith) with a Molotov cocktail, burning him to death. Brigance's attraction to Roark grows, and they nearly begin an affair before Brigance regains his wits. He goes home, finding that arsonists have burned down his house, nearly killing his dog Max in the process. The next morning, as the Mississippi National Guard is called in to take care of the rioting, Brigance sits on the still-smoking steps of his house, calling for his dog. Harry Rex arrives at the remains of the Brigance home and tells Jake that it is time to quit the case. Brigance argues that to quit now would make his sacrifices meaningless. The jury secretly discusses the case in a restaurant, going against the judge's instructions. All but one are leaning toward a guilty verdict and Carl Lee's fate looks sealed.Freddie Lee Cobb shoots at Brigance as he exits the courthouse, but misses. The bullet hits a national guardsman policing the demonstrations, paralyzing him. Roark is kidnapped by", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}528{"query": "Alexander Bertschler (born 11 July 1994) is a male recurve archer from Austria.", "pos": "Wouter Claes (born 28 October 1975 in Leuven, Belgium) is a male left-handed Belgian badminton player.", "neg": "Clube Atletico Carlos Renaux played their home games at Estadio Augusto Bauer.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}529{"query": "The Ehlers-Danlos syndromes (EDS) are a heterogeneous group of heritable connective tissue disorders characterised by joint hypermobility, involvement of skin and tissue fragility. The Villefranche criteria have simplified its diagnosis, which, however, remains difficult in children and young adults with vascular and hypermobile EDS as well as in patients without a positive family history. Diagnosis of vascular EDS is important for clinical follow-up, genetic counseling and prenatal diagnosis. We describe the biochemical and molecular-genetic diagnosis of vascular EDS. We describe five families with vascular EDS. Analysis of (pro)collagens obtained from cultured fibroblasts was done using SDS-PAGE. The structure and amounts of (pro)collagen I, III and V were determined by autoradioflourography. This was also done in 362 controls or patients without a diagnosis of vascular EDS. Molecular testing was done in Professor Anne de Paepe's laboratory in Belgium by sequencing of COL3A1. (Pro)collagen from all five patients with vascular EDS was abnormal by SDS-PAGE: intracellular retention, reduced secretion and overmodification of the a1 chains of (pro)collagen III. Molecular analysis revealed an abnormality of COL3A1 in all patients. Abnormalities of (pro)collagen III were not observed in patients without a diagnosis of vascular EDS. Among 90 patients with non-vascular EDS, one patient had an abnormality of collagen I. Biochemical analysis of (pro)collagen obtained from cultured fibroblasts is a good screening procedure for vascular EDS, but it is of limited value in non-vascular EDS. Molecular testing will disclose an abnormality of COL3A1 in many patients with abnormal (pro)collagen III on SDS-PAGE. The findings make precise genetic counselling and prenatal diagnosis possible in families with vascular EDS.", "pos": "The Ehlers-Danlos syndromes (EDS) are a group of heritable connective tissue disorders that share the common features of skin hyperextensibility, articular hypermobility, and tissue fragility. Considerable clinical and genetic heterogeneity exists, and more than nine separate forms have been recognized. Recent advances in the molecular analysis of EDS have identify defects responsible for EDS VI (homozygous and compound heterozygous mutations in the lysyl-hydroxylase gene), EDS VIIA and EDS VIIB (mutations in the type I collagene genes), EDS VIIC (deficiency of procollagen N-proteinase), EDS IX (mutations in the MNK gene), and EDS IV (mutations in the type III collagen gene). Of the various types of Ehlers-Danlos syndrome the most severe is type IV (EDS IV). Early studies showed that fibroblasts from EDS IV patients secreted lower than normal amounts of type III procollagen (Pope et al., 1975). Later, the disease was linked to COL3A1, the gene encoding this protein. More recently, with the publication of full length cDNA and partial characterisation of the gene structure, detailed analysis of mutations in EDS IV patients has become possible. Nineteen different mutations in the type III procollagen gene have been reported in different families with EDS IV. Recent results support the hypothesis that in EDS IV, dominant inheritance should be assumed, in sporadic cases also, unless proven otherwise. Very little is known about the genetics or biochemicals defects responsible for the others EDS subtypes, but with the applications of the tools of molecular biology, analysis of these defects if now within reach.", "neg": "Heme is critical for a variety of cellular processes, but excess intracellular heme may result in oxidative stress and membrane injury. Feline leukemia virus subgroup C receptor (FLVCR1), a member of the SLC49 family of four paralogous genes, is a cell surface heme exporter, essential for erythropoiesis and systemic iron homeostasis. Disruption of FLVCR1 function blocks development of erythroid progenitors, likely due to heme toxicity. Mutations of SLC49A1 encoding FLVCR1 are noted in patients with a rare neurodegenerative disorder: posterior column ataxia with retinitis pigmentosa. FLVCR2 is highly homologous to FLVCR1 and may function as a cellular heme importer. Mutations of SLC49A2 encoding FLVCR2 are observed in Fowler syndrome, a rare proliferative vascular disorder of the brain. The functions of the remaining members of the SLC49 family, MFSD7 and DIRC2 (encoded by the SLC49A3 and SLC49A4 genes), are unknown, although the latter is implicated in hereditary renal carcinomas. SLC48A1 (heme responsive gene-1, HRG-1), the sole member of the SLC48 family, is associated with the endosome and appears to transport heme from the endosome into the cytosol.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}530{"query": "Welcome to Adventureland! Everyone loves Adventureland !The Parks and Exhibitions were built for you to explore ,enjoy,and admire their wonders.Every visit will be an unforgettable experience.You will go away enriched,longing to come back.What are you going to do this time? The Travel Pavilion Explore places you have never been to before,and experience different ways of life.Visit the Amazon jungle village,the Turkish market,the Tai floating market,the Berber mountain house and others.Talk to the people there who will tell you about their lives,and things they make.You can try making a carpet,making nets,fishing... The Future Tower This exhibition shows how progress will touch our lives.It allows us to look into the future and explore the cities of the next century and the way we'll be living then.Spend some time in our space station and climb into our simulator for the Journey to Mars! The Nature Park This is not really one park but several.In the Safari Park you can drive among African animals in one of our Range Cruisers:see lions,giraffes,elephants in the wild.Move on to the Ocean Park to watch the dolphins and whales.And then there is still the Aviary to see... The Pyramid This is the center of Adventureland.Run out of film,need some postcards and stamps?For all these things and many more,visit our underground shopping center.Come here for information and ideas too.", "pos": "With thousands of years of history and mythology in its area, prefix = st1 /Athens--named for the olive-tree-loving Athena---is more than a concrete jungle. It's a lovely city decorated by outdoor cafes, pedestrian streets, parks, gardens and plenty of characters. _ The city is connected three sides by Mt Parnitha, Mt Pendeli and Mt Hymettos. WithinAthensthere are no less than eight hills, of which the Acropolis and Lykavitos are the most famous. The hills provide a peaceful rest from the noise of the city. Just about everything of interest to the traveler is within a small area surrounding Plateia Syntagmatos (Syntagma Square). This area is connected with the districts of Plaka to the south, Monastiraki to the west, Kolonaki to the east and Omaonia to the north. Plateia Syntagmatos is dominated by the oldRoalPalaceand is the beating heart of the business district, with luxury hotels, banks and airline offices. Plaka, nestled below the Acropolis, is the old Turkish quarter and virtually all that existed when Athens was declared the capital of independentGreece. Though Plaka is packed with tourists in high season, it's also one of the prettiest and most atmospheric areas of the city. Monastiraki is the market district and a fascinating part of town to wander. Psiri, nearby, is full of stylish cafes and bars and makes a great place to stop for a rest of lunch. Kolonaki, a classy living area, is full of trendy boutiques, art galleries and cafes.", "neg": "People from all over the world visit Disneyland to have fun, not to get sick. But last week, an outbreak of measles spread from the Southern California theme park. As of Monday, January 19, at least 52 people have got the easily spread illness. The majority of the reported cases of measles are from people who visited the park before. According to the California Department of Public Health, these people were exposed to the illness at Disneyland from December 17-20. Officials believe the cause is likely someone who caught measles abroad and visited Disneyland, but this has yet to be proved. However, in 2014, California had its highest measles infection rate in nearly twenty years. There were 66 cases of measles reported in the state--23 of them in Orange County, where Disneyland is located. Measles spreads very easily. It can be caught from coughing and sneezing. Crowded areas like theme parks are especially suitable for its spread. The illness starts with a fever and develops into symptoms including a cough, runny nose, red eyes and so on. About three out of ten people infected with measles will develop another health problem, including an ear infection or pneumonia . The best way to _ measles is to get vaccinated . An unvaccinated person is 35 times more likely to catch measles than someone who received a vaccination.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}531{"query": "The Gora Rudnaya mine is one of the largest gold mines in Russia and in the world.", "pos": "The Quartz Mountain mine is one of the largest gold mines in Canada and in the world.", "neg": "The 2016 World Single Distance Speed Skating Championships will be held between 11 and 14 February 2016 in Kolomna, Russia.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}532{"query": "Force is defined as a push or a pull acting on an object. Examples of forces include friction and gravity. Both are covered in detail later in this chapter. Another example of force is applied force. It occurs when a person or thing applies force to an object, like the girl pushing the swing in Figure 13.1. The force of the push causes the swing to move. Force is a vector because it has both size and direction. For example, the girl in Figure 13.1 is pushing the swing away from herself. Thats the direction of the force. She can give the swing a strong push or a weak push. Thats the size, or strength, of the force. Like other vectors, forces can be represented with arrows. Figure 13.2 shows some examples. The length of each arrow represents the strength of the force, and the way the arrow points represents the direction of the force. How could you use an arrow to represent the girls push on the swing in Figure 13.1? The SI unit of force is the newton (N). One newton is the amount of force that causes a mass of 1 kilogram to accelerate at 1 m/s2 . Thus, the newton can also be expressed as kgm/s2 . The newton was named for the scientist Sir Isaac Newton, who is famous for his law of gravity. Youll learn more about Sir Isaac Newton later in the chapter. More than one force may act on an object at the same time. In fact, just about all objects on Earth have at least two forces acting on them at all times. One force is gravity, which pulls objects down toward the center of Earth. The other force is an upward force that may be provided by the ground or other surface. Consider the example in Figure 13.3. A book is resting on a table. Gravity pulls the book downward with a force of 20 newtons. At the same time, the table pushes the book upward with a force of 20 newtons. The combined forces acting on the book or any other object are called the net force. This is the overall force acting on an object that takes into account all of the individual forces acting on the object. You can learn more about the concept of net force at this URL: . When two forces act on an object in opposite directions, like the book on the table, the net force is equal to the difference between the two forces. In other words, one force is subtracted from the other to calculate the net force. If the opposing forces are equal in strength, the net force is zero. Thats what happens with the book on the table. The upward force minus the downward force equals zero (20 N up - 20 N down = 0 N). Because the forces on the book are balanced, the book remains on the table and doesnt move. In addition to these downward and upward forces, which generally cancel each other out, forces may push or pull an object in other directions. Look at the dogs playing tug-of-war in Figure 13.4. One dog is pulling on the rope with a force of 10 newtons to the left. The other dog is pulling on the rope with a force of 12 newtons to the right. These opposing forces are not equal in strength, so they are unbalanced. When opposing forces are unbalanced, the net force is greater than zero. The net force on the rope is 2 newtons to the right, so the rope will move to the right. Two forces may act on an object in the same direction. You can see an example of this in Figure 13.5. After the man on the left lifts up the couch, he will push the couch to the right with a force of 25 newtons. At the same time, the man to the right is pulling the couch to the right with a force of 20 newtons. When two forces act in the same direction, the net force is equal to the sum of the forces. This always results in a stronger force than either of the individual forces", "pos": "Work is defined differently in physics than in everyday language. In physics, work means the use of force to move an object. The teen who is playing tennis in Figure 16.1 is using force to move her tennis racket, so she is doing work. The teen who is studying isnt moving anything, so she is not doing work. Not all force that is used to move an object does work. For work to be done, the force must be applied in the same direction that the object moves. If a force is applied in a different direction than the object moves, no work is done. Figure 16.2 illustrates this point. The stick person applies an upward force on the box when raising it from the ground to chest height. Work is done because the force is applied in the same direction as the box is moving. However, as the stick person walks from left to right while holding the box at chest height, no more work is done by the persons arms holding the box up. Thats because the force supporting the box acts in a different direction than the box is moving. A small amount of work in the horizontal direction is performed when the person is accelerating during the first step of the walk across the room. But other than that, there is no work, because there is no net force acting on the box horizontally. Work is directly related to both the force applied to an object and the distance the object moves. It can be represented by the equation: Work = Force Distance This equation shows that the greater the force that is used to move an object or the farther the object is moved, the more work that is done. You can see a short video introduction to work as the product of force and distance at this link: . To see the effects of force and distance on work, compare the weight lifters in Figure 16.3. The two weight lifters on the left are lifting the same amount of weight, but the bottom weight lifter is lifting the weight a longer distance. Therefore, this weight lifter is doing more work. The two weight lifters on the bottom right are both lifting the weight the same distance, but the weight lifter on the left is lifting a heavier weight. Therefore, this weight lifter is doing more work. The equation for work given above can be used to calculate the amount of work that is done if force and distance are known. For example, assume that one of the weight lifters in Figure 16.2 lifts a weight of 400 newtons over his head to a height of 2.2 meters off the ground. The amount of work he does is: Work = 400 N 2.2 m = 880 N m Notice that the unit for work is the newton meter. This is the SI unit for work, also called the joule (J). One joule equals the amount of work that is done when 1 newton of force moves an object over a distance of 1 meter. Problem Solving Problem: Todd pushed a 500 N box 4 meters across the floor. How much work did he do? Solution: Use the equation Work = Force Distance. Work = 500 N 4 m = 2000 N m, or 2000 J You Try It! Problem: Lara lifted a 100 N box 1.5 meters above the floor. How much work did she do? Did you ever rake leaves, like the woman in Figure 16.4? It can take a long time to do all that work. But if you use an electric leaf blower, like the man in the figure, the job gets done much sooner. Both the leaf blower and the rake do the work of removing leaves from the yard, but the leaf blower has more power. Thats why it can do the same amount of work in less time. Power is a measure of the amount of work that can be done in a given amount of time. Power can be represented by the equation: Power = Work Time In this equation, work is measured in joules and time is measured in seconds, so power is expressed in joules per second (J/", "neg": "The Outdoor Centre Opening times Water sports: 10 a.m. -- 6 p.m. Play Park: 10 a.m. -- 5:30 p.m. Windsurfing -- One-day course Beginner windsurfing courses are offered on Saturdays and Sundays when the weather is good enough. Learning to windsurf is a lot of fun. The excitement when you sail across the water for the first time is not easily forgotten. Boards with small sails are available for beginners. Course fee: PS32 for adults; PS16 for children under 16 (this includes all equipment) One-day adventure course This is the opportunity you have been waiting for. Come and try sailing, climbing, surfing and archery . This course is intended to introduce outdoor activities to adults in a fun and leisurely manner. You do not need to be very fit or to have previous experience with the activities. All you need is to be interested. Course fee: PS22.50 Play Park The Play Park is suitable for children from two to ten years of age. It is one of the best of its type in the country. It has sand and water playgrounds, slides, large pool balls, a play castle and much, much more. Next year the center will open Play Palace and Play Ship. Summer adventure holidays Sailing, Climbing, Windsurfing, Fun Games Fee: PS50 for adults; PS30 for children under 16 Statement: Safety is of primary importance at the Outdoor Center. All staff members are fully trained in first aid, and qualified to teach the activities on offer. We also make sure that all children only take part in activities that are suitable for their ages and physical abilities. For this programme children must be able to swim 25 metres and be in good physical health.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}533{"query": "Our objective was to evaluate the efficacy of influenza and meningococcal vaccinations in healthy subjects exposed to the anti-interleukin-17A (IL-17A) monoclonal antibody (MAb) secukinumab. We used an open-label, parallel-group, randomized single-center study of 50 healthy subjects. Subjects received a single 150-mg dose of secukinumab or no treatment, followed by vaccination with inactivated trivalent subunit influenza virus and conjugate group C meningococcal vaccine (Agrippal and Menjugate, respectively) 2 weeks later. Primary efficacy variables were responses of 4-fold increases in antibody titer (hemagglutination inhibition [HI; for influenza virus] and serum bactericidal assay [SBA; for Neisseria meningitides]) for meningococcus and influenza (at least two out of three serotypes), both at 4 weeks postvaccination. All subjects randomized to secukinumab (n = 25) or the control (n = 25) completed the study. Antibody responses to vaccinations measured at 4 weeks were comparable in both groups, with 4-fold increased responses following influenza virus vaccination of 20/25 (80%) for both groups and following meningococcal vaccination of 19/25 (76%) for the secukinumab group and 18/25 (72%) for the control group. Differences between groups were 0% (90% confidence intervals [CI], 19 and 19%) and 4% (90% CI, 16 and 24%) for influenza virus and meningococcal vaccines, respectively. Antibody responses were comparable between the 2 groups at different time points. Headache was the most frequently reported adverse effect. No deaths or serious adverse events were reported. Blockade of IL-17A by secukinumab does not appear to interfere with efficacy of influenza and meningococcal vaccinations, as assessed by the achievement of protective antibody levels. A protective (4-fold) immune response to both vaccinations at 4 weeks was achieved in 80 and 76% of subjects exposed to secukinumab and the control, respectively.", "pos": "To determine the efficacy and safety of different doses of secukinumab, a fully human monoclonal antibody for targeted interleukin-17A blockade, in patients with noninfectious uveitis. Three multicenter, randomized, double-masked, placebo-controlled, dose-ranging phase III studies: SHIELD, INSURE, and ENDURE. A total of 118 patients with Behcet's uveitis (SHIELD study); 31 patients with active, noninfectious, non-Behcet's uveitis (INSURE study); and 125 patients with quiescent, noninfectious, non-Behcet's uveitis (ENDURE study) were enrolled. After an initial subcutaneous (s.c.) loading phase in each treatment arm, patients received s.c. maintenance therapy with secukinumab 300 mg every 2 weeks (q2w), secukinumab 300 mg monthly (q4w), or placebo in the SHIELD study; secukinumab 300 mg q2w, secukinumab 300 mg q4w, secukinumab 150 mg q4w, or placebo in the INSURE study; or secukinumab 300 mg q2w, secukinumab 300 mg q4w, secukinumab 150 mg q4w, or placebo in the ENDURE study. Reduction of uveitis recurrence or vitreous haze score during withdrawal of concomitant immunosuppressive medication (ISM). Other end points included best-corrected visual acuity, ISM use (expressed as a standardized ISM score), and safety outcomes. After completion or early termination of each trial, there were no statistically significant differences in uveitis recurrence between the secukinumab treatment groups and placebo groups in any study. Secukinumab was associated with a significant reduction in mean total post-baseline ISM score (P = 0.019; 300 mg q4w vs. placebo) in the SHIELD study. Likewise, secukinumab was associated with a greater median reduction in ISM score versus placebo in the INSURE study, although no statistical analysis of the difference was conducted because of the small sample size. Overall, there was no loss in visual acuity reported in any treatment group during follow-up in all 3 studies. According to descriptive safety statistics, the frequencies of ocular and nonocular adverse events seemed to be slightly higher among secukinumab groups versus placebo across the 3 studies. The primary efficacy end points of the 3 studies were not met. The secondary efficacy data from these studies suggest a beneficial effect of secukinumab in reducing the use of concomitant ISM.", "neg": "Our objective was to evaluate the diagnostic value of computed tomography angiography (CTA) and ventilation perfusion (V/Q) scan in the assessment of pulmonary embolism (PE) by means of a Bayesian statistical model. Wells criteria defined pretest probability. Sensitivity and specificity of CTA and V/Q scan for PE were derived from pooled meta-analysis data. Likelihood ratios calculated for CTA and V/Q were inserted in the nomogram. Absolute (ADG) and relative diagnostic gains (RDG) were analyzed comparing post- and pretest probability. Comparative gain difference was calculated for CTA ADG over V/Q scan integrating ANOVA p value set at 0.05. The sensitivity for CT was 86.0% (95% CI: 80.2%, 92.1%) and specificity of 93.7% (95% CI: 91.1%, 96.3%). The V/Q scan yielded a sensitivity of 96% (95% CI: 95%, 97%) and a specificity of 97% (95% CI: 96%, 98%). Bayes nomogram results for CTA were low risk and yielded a posttest probability of 71.1%, an ADG of 56.1%, and an RDG of 374%, moderate-risk posttest probability was 85.1%, an ADG of 56.1%, and an RDG of 193.4%, and high-risk posttest probability was 95.2%, an ADG of 36.2%, and an RDG of 61.35%. The comparative gain difference for low-risk population was 46.1%; in moderate-risk 41.6%; and in high-risk a 22.1% superiority. ANOVA analysis for LR+ and LR- showed no significant difference (p=0.8745, p=0.9841 respectively). This Bayesian model demonstrated a superiority of CTA when compared to V/Q scan for the diagnosis of pulmonary embolism. Low-risk patients are recognized to have a superior overall comparative gain favoring CTA.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}534{"query": "Water is a simple chemical compound. Each molecule of water contains two hydrogen atoms (H2 ) and one oxygen atom (O). Thats why the chemical formula for water is H2 O. If water is so simple, why is it special? Water is one of the few substances that exists on Earth in all three states of matter. Water occurs as a gas, a liquid and a solid. You drink liquid water and use it to shower. You breathe gaseous water vapor in the air. You may go ice skating on a pond covered with solid water ice in the winter. Earth is often called the water planet. Figure 13.1 shows why. If astronauts see Earth from space, this is how it looks. Notice how blue the planet appears. Thats because oceans cover much of Earths surface. Water is also found in the clouds that rise above the planet. Most of Earths water is salt water in the oceans. As Figure 13.2 shows, only 3 percent of Earths water is fresh. Freshwater is water that contains little or no dissolved salt. Most freshwater is frozen in ice caps and glaciers. Glaciers cover the peaks of some tall mountains. For example, the Cascades Mountains in North America and the Alps Mountains in Europe are capped with ice. Ice caps cover vast areas of Antarctica and Greenland. Chunks of ice frequently break off ice caps. They form icebergs that float in the oceans. Did you ever wonder where the water in your glass came from or where its been? The next time you take a drink of water, think about this. Each water molecule has probably been around for billions of years. Thats because Earths water is constantly recycled. Water is recycled through the water cycle. The water cycle is the movement of water through the oceans, atmo- sphere, land, and living things. The water cycle is powered by energy from the Sun. Figure 13.3 diagrams the water cycle. Water keeps changing state as it goes through the water cycle. This means that it can be a solid, liquid, or gas. How does water change state? How does it keep moving through the cycle? As Figure 13.3 shows, several processes are involved. Evaporation changes liquid water to water vapor. Energy from the Sun causes water to evaporate. Most evaporation is from the oceans because they cover so much area. The water vapor rises into the atmosphere. Transpiration is like evaporation because it changes liquid water to water vapor. In transpiration, plants release water vapor through their leaves. This water vapor rises into the atmosphere. Condensation changes water vapor to liquid water. As air rises higher into the atmosphere, it cools. Cool air can hold less water vapor than warm air. So some of the water vapor condenses into water droplets. Water droplets may form clouds. Precipitation is water that falls from clouds to Earths surface. Water droplets in clouds fall to Earth when they become too large to stay aloft. The water falls as rain if the air is warm. If the air is cold, the water may freeze and fall as snow, sleet, or hail. Most precipitation falls into the oceans. Some falls on land. Runoff is precipitation that flows over the surface of the land. This water may travel to a river, lake, or ocean. Runoff may pick up fertilizer and other pollutants and deliver them to the water body where it ends up. In this way, runoff may pollute bodies of water. Infiltration is the process by which water soaks into the ground. Some of the water may seep deep under- ground. Some may stay in the soil, where plants can absorb it with their roots. In all these ways, water keeps cycling. The water cycle repeats over and over again. Who knows? Maybe a water molecule that you drink today once quenched the thirst of a dinosaur.", "pos": "The movement of water around Earths surface is the hydrological (water) cycle (Figure 1.1). Water inhabits reservoirs within the cycle, such as ponds, oceans, or the atmosphere. The molecules move between these reservoirs by certain processes, including condensation and precipitation. There are only so many water molecules and these molecules cycle around. If climate cools and glaciers and ice caps grow, there is less water for the oceans and sea level will fall. The reverse can also happen. The following section looks at the reservoirs and the processes that move water between them. The Sun, many millions of kilometers away, provides the energy that drives the water cycle. Our nearest star directly impacts the water cycle by supplying the energy needed for evaporation. Most of Earths water is stored in the oceans, where it can remain for hundreds or thousands of years. Water changes from a liquid to a gas by evaporation to become water vapor. The Suns energy can evaporate water from the ocean surface or from lakes, streams, or puddles on land. Only the water molecules evaporate; the salts remain in the ocean or a fresh water reservoir. The water vapor remains in the atmosphere until it undergoes condensation to become tiny droplets of liquid. The droplets gather in clouds, which are blown about the globe by wind. As the water droplets in the clouds collide and grow, they fall from the sky as precipitation. Precipitation can be rain, sleet, hail, or snow. Sometimes precipitation falls back into the ocean and sometimes it falls onto the land surface. When water falls from the sky as rain it may enter streams and rivers that flow downward to oceans and lakes. Water that falls as snow may sit on a mountain for several months. Snow may become part of the ice in a glacier, where it may remain for hundreds or thousands of years. Snow and ice may go directly back into the air by sublimation, the process in which a solid changes directly into a gas without first becoming a liquid. Although you probably have not seen water vapor undergoing sublimation from a glacier, you may have seen dry ice sublimate in air. Snow and ice slowly melt over time to become liquid water, which provides a steady flow of fresh water to streams, rivers, and lakes below. A water droplet falling as rain could also become part of a stream or a lake. At the surface, the water may eventually evaporate and reenter the atmosphere. A significant amount of water infiltrates into the ground. Soil moisture is an important reservoir for water (Figure The moisture content of soil in the United States varies greatly. Water may seep through dirt and rock below the soil and then through pores infiltrating the ground to go into Earths groundwater system. Groundwater enters aquifers that may store fresh water for centuries. Alternatively, the water may come to the surface through springs or find its way back to the oceans. Plants and animals depend on water to live. They also play a role in the water cycle. Plants take up water from the soil and release large amounts of water vapor into the air through their leaves (Figure 1.3), a process known as transpiration. People also depend on water as a natural resource. Not content to get water directly from streams or ponds, humans create canals, aqueducts, dams, and wells to collect water and direct it to where they want it (Figure 1.4). Clouds form above the Amazon Rainfor- est even in the dry season because of moisture from plant transpiration. Pont du Gard in France is an ancient aqueduct and bridge that was part of of a well-developed system that supplied wa- ter around the Roman empire. Click image to the left or use the URL below. URL:", "neg": "Water is simply two atoms of hydrogen and one atom of oxygen bonded together (Figure 1.1). The hydrogen ions are on one side of the oxygen ion, making water a polar molecule. This means that one side, the side with the hydrogen ions, has a slightly positive electrical charge. The other side, the side without the hydrogen ions, has a slightly negative charge. Despite its simplicity, water has remarkable properties. Water expands when it freezes, has high surface tension (because of the polar nature of the molecules, they tend to stick together), and others. Without water, life might not be able to exist on Earth and it certainly would not have the tremendous complexity and diversity that we see. Water is the only substance on Earth that is present in all three states of matter - as a solid, liquid or gas. (And Earth is the only planet where water is abundantly present in all three states.) Because of the ranges in temperature in specific locations around the planet, all three phases may be present in a single location or in a region. The three phases are solid (ice or snow), liquid (water), and gas (water vapor). See ice, water, and clouds (Figure 1.2). (a) Ice floating in the sea. Can you find all three phases of water in this image? (b) Liquid water. (c) Water vapor is invisible, but clouds that form when water vapor condenses are not. Click image to the left or use the URL below. URL:", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}535{"query": "The film starts with a brief recollection of the \"Killing Angel\", a dangerous assassin that has been operating in most of southeast Asia. The Killing Angel has no known accomplices or colleagues, is not affiliated with any government, religious, or criminal organization, and to this date their true identity has still remained secret. The Killing Angel is believed to be responsible for 6 murders in the past year alone, with only one thing connecting each of the assassinations - all the victims were criminals and deserved to die.Then the movie quickly moves on to the Killing Angel's most recent killing, the well-publicized assassination of a notorious ex-yakuza crime boss. Working swiftly, the Killing Angel is able to overcome the criminal's defense systems, quickly incapacitating the boss's bodyguards and isolating his target. In a fit of desperation, the crime boss promises to triple whatever fee the Killing Angel is being paid to kill him, then goes on to warn the vigilante that there is a massive revenge fund set to avenge his killing. Ignoring his pleas, the Killing Angel silently kills the crime boss.The scene then switches over to the story of Fu (Jet Li), a small-town gang member who lives an extremely simple and modest lifestyle, albeit being a contract killer. It is revealed that Fu is very kind and has trouble killing innocent people, a trait that causes him to be disliked by the other low-rent triad members. When Fu's boss reveals that there is now a $100 million US bounty on the Killing Angel's head for the slaying of the yakuza boss, Fu is quick to volunteer for the job, but is instead insulted.Fu then attempts to enter the building where the crime boss's lawyers are discussing the terms for the revenge fund, but is detained at the entrance and ushered out by security guards. In a surprisingly quick sequence, Fu defends himself by rapidly incapacitating each of the guards. His lightning-swift martial arts skills draw the attention of Ngok Lo, played by Eric Tsang, a seedy contract booker and loan shark, who comes to Fu's aid by pretending that he is an agent and Fu is his actor. Thanks to Lo's smooth talking, the pair is able to sidle into the meeting.The meeting however, comes to a halt when government agents, led by detective Chan (Simon Yam), raid the building in search of known criminals who are meeting there. Chan, a leading detective, has been working tirelessly to expose the Killing Angel's true identity for years. The movie then switches over to another sequence, where the character of Eiji Tsukamoto, the slain crime boss's grandson, played by Renji Sato, is introduced. Tsukamoto, fed up with his grandfather's cowardice in life, now seeks his grandfather's power in death. Tsukamoto consumes a portion of his grandfather's cremated ashes, an act that causes the deceased lord's top aid to call him insane, but now all of the family's agents and gang members serve Tsukamoto as their new master.Fu and Lo get to know each other - Fu is an ex-soldier from mainland China, part of a special, world-famous unit known as the \"Golden Soldiers\". When Lo asks for a demonstration of Fu's skills, he is able to rapidly take down several ruffians simultaneously, but falters when he is confronted by a woman. Lo then explains the deal with Fu, and they head for an amusement park to assassinate the first person believed to be the Killing Angel. However, when they get there, it is revealed their target is a simple family man, and instead of killing him, Fu saves his life by killing his other assassins, the low-rank triad members he formerly lived with.Fu and Lo are then arrested, but they are bailed out by Lo's daughter, Kiki (Gigi Leung), an intelligent and successful lawyer fed up with her father's scandalous ways and criminal connections. Fu moves in with Lo now that he has no place to stay, and they quickly become friends, Lo claiming he used to be an infamous hitman known", "pos": "John Strangways, the British Intelligence (SIS) Station Chief in Jamaica, is ambushed, killed, and his body taken by three assassins known as the \"Three Blind Mice\". In response, MI6 agent James Bond (007) is summoned to the office of his superior, M. Bond is briefed to investigate Strangways' disappearance and to determine whether it is related to his cooperation with the American Central Intelligence Agency (CIA) on a case involving the disruption of Cape Canaveral rocket launches by radio jamming.Upon his arrival at Kingston Airport, a female photographer tries to take Bond's picture and he is shadowed from the airport. He is picked up by a chauffeur, who Bond determines to be an enemy agent. Bond instructs him to leave the main road and, after a brief fight, Bond starts to interrogate the driver, who then kills himself with a cyanide-embedded cigarette.During his investigation Bond sees a picture of a boatman named Quarrel with Strangways. Bond locates Quarrel but finds him to be un-cooperative when he interviews him. Bond also recognises Quarrel to have been the driver of the car that chased him from the airport. Bond follows Quarrel and is about to be beaten by him and a friend when the fight is interrupted by the man from the airport who has been following Bond: he reveals himself to be CIA agent Felix Leiter and that not only are the two agents on the same mission, but also that Quarrel is helping Leiter. The CIA has traced the mysterious radio jamming of American rockets to the Jamaica vicinity, but aerial photography cannot see the exact location of its origin. Quarrel reveals that he has been guiding Strangways around the nearby islands to collect mineral samples. He also tells about the island of Crab Key, owned by the reclusive Dr. No, who operates a bauxite mine which is rigorously protected against trespassers by an armed security force and low-scan radar.After finding a receipt in Strangways' house about mysterious rocks naming, Professor R.J. Dent, Bond meets with Dent who says he had assayed the samples for Strangways and determined them to be ordinary rocks. This visit makes Dent wary and he takes a boat to Crab Key where Dr. No expresses displeasure at Dent's failure to kill Bond and orders him to try again, this time with a large venomous spider. Bond survives and kills the spider.Bond becomes friendly with Strangways' secretary, Miss Taro and agrees to meet her at her home in the hills above Kingston. While driving there, Bond is attacked by several men driving a large hearse. He is able to outmaneuver them and the hearse is run off the mountain road and explodes. When Bond shows up at Taro's house, she's surprised to see him, a fact that Bond notes easily. She goes into her bedroom and talks on the phone to her boss, who tells her to keep Bond occupied for a few hours. Bond and Taro spend that time in bed.Bond makes a phone call, ostensibly asking for a taxi but actually talking to the local police, who show up soon after and arrest Taro. Bond then sets a trap for Dent and waits for him to show. Dent steals into the bedroom and fires several silenced shots into the bed, which Bond rigged to look like it was occupied. Bond forces Dent to drop his pistol and begins to interrogate him about Strangways and his radioactive rock samples, which Dent tried to cover up. Dent is able to recover his pistol, finding it empty and Bond coldly shoots him dead.Having detected radioactive traces in Quarrel's boat, where Strangways' mineral samples had been, Bond convinces a reluctant Quarrel to take him to Crab Key. On the beach there, Bond meets the beautiful Honey Ryder, dressed only in a white bikini, who is collecting shells. At first she is suspicious of Bond but soon decides to help him, leading them all inland to an open swamp. After nightfall they are attacked by the legendary \"dragon\" of Crab Key which turns out to be a flame-throwing armoured vehicle. In the resulting gun battle, Quarrel is incinerated by the flame-thrower whilst Bond and Honey are", "neg": "An English teacher named Seiji Hasumi (Hideaki Ito) is loved by his students and respected by his peers. He graduates from Harvard University with an MBA, and works at Morgenstern, a European investment bank, for two years. Hasumi returns to Japan to pursue high school teaching. However, his outward charm masks his true nature. In reality, Hasumi is a sociopath who is unable to feel empathy for other human beings. Specifically, he has a severe antisocial personality disorder. Having killed both of his parents and his former tutor at the age of fourteen, Hasumi turns into a fiendishly clever killer. During his time in the States, Hasumi meets a partner in crime, an American named Dave, who thinks he shares the same \"hobby\" as Hasumi killing people for fun. The two can be seen carrying buckets full of human blood, bones, and organs somewhere, giving off the notion that they committed numerous murders while working together. Hasumi eventually kills his partner by knocking him out and burning him alive inside a barrel, stating that while Dave enjoys killing for fun, Hasumi does not. Back in Japan, Hasumi chooses to deal with problems like bullying and student sexual harassment, starting by dealing with the school cheating issue. Upon collecting all of the students' cell phones prior to their exams, Hasumi secretly uses a cell phone jammer to completely prevent any cheating during the test. The group of students that had cheated on previous exams became suspicious after none of the group's cell phones have service during the test and immediately suspect the adviser of the Radio Club, Tsurii - a loner Physics teacher. They are then confronted by Tsurii himself who clarifies that he was not responsible for the jamming. A man who regularly meets with the school to complain about students bullying his daughter, Rina, is murdered. Someone has replaced the bottles of water he kept around his house to scare off cats with kerosene, as the man is a chainsmoker the bottles soon catch fire and explode. Tsurii soon meets with the intelligent ringleader of the cheating group, Keisuke, revealing his suspicions of Hasumi. Tsurii explains he has dug into Hasumi's past and found strange details, such as at another school where Hasumi started his teaching career that later had four student suicides. During this time, however, Hasumi had bugged the room and learned of Tsurii's suspicion, and confronts him on a train, murdering him and making his death appear as a hanging suicide. Hasumi then confronts Keisuke after the announcement of Tsurii's suicide causes him to panic. Hasumi knocks Keisuke out and ties him up until the end of school, after which Hasumi tortures him into admitting that he and his friends were indeed cheating. Hasumi checks that Keisuke didn't tell others of Tsurii's suspicions, before killing him and hiding his body. During the same time period, Hasumi is brought to the attention of a blackmail case from one of his students. A store owner, Meka, caught a female student, Miya, shoplifting but swears not to charge her for it. However, PE teacher Shibahara blackmails Miya, as he has recorded her admission of shoplifting, into giving him sexual favors or risk being charged. Hasumi, assures Miya that a blackmail and statutory rape case is more serious than shoplifting and affirms to her that she is safe from the law and no longer needs to succumb to the blackmail. Miya later meets Hasumi on the school roof, she thanks him with a hug that advances into a kiss and the two become lovers. In the meantime, Hasumi finds out about art teacher Kume's sexual relationship with a male student; he blackmails Kume into lending him his luxury apartment. Hasumi later takes Miya to the apartment and the two have sex. Hasumi presses Miya into giving him access to an online private discussion board that his students use, anonymously making claims about the murder of Rina's father, accusing delinquent student Tadenuma, who had targeted Rina online previously. After a fight breaks out at the school, Hasumi invites Tadenuma out for a drink and murders him; the students later assume that Tadenuma ran away from home. Events have passed until Hasumi's homeroom students are", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}536{"query": "The Cardinals dueled with the Minnesota Vikings for the #3 seed in the NFC playoffs. Things looked bleak for the Cardinals from the beginning. The Vikings began their first quarter attack with an 82-yard punt return for a TD by Bernard Berrian. Two turnovers for the Cardinals, Kurt Warner interception and an Anquan Boldin fumble, would lead to two touchdown passes from Tarvaris Jackson, a 41-yard pass to Berrian and a 19-yard pass to Sidney Rice. The Vikings took a 28-0 lead at halftime after an 11-yard TD pass from Jackson to Chester Taylor. The Cardinals would rally to cut the lead in half with a Jerheme Urban 50-yard TD catch and a field goal blocked by Dominique Rodgers-Cromartie and recovered by Roderick Hood, who returned it 68 yards for a touchdown. The Vikings would pull away at the end of the third quarter when Jackson threw a 59-yard TD pass to Bobby Wade. Kurt Warner was benched on the Cardinals last drive in the fourth quarter via a coaching decision.", "pos": "The Patriots faced the Denver Broncos in a rematch of the previous season's AFC Championship game. The Broncos won the coin toss and elected to kick. Beginning at their own 24, the Patriots went were unable to get a first down causing them to punt. Unluckily for the Broncos, during Ryan Allen's punt Jordan Norwood muffed the punt and the Patriots obtained it with a Jonathan Jones recovery. The Patriots began at the Denver 31. Unfortunately for the Patriots, they were unable to get a first down and were forced to settle with a Stephen Gostkowski 45-yard field goal for 3 points. The Broncos began the ball on their own 25 on the next possession. They started off well with a 13-yard run by Justin Forsett. However, they were unable to get a first down. On the Patriots next drive, they began at their own 15. On the beginning of the first play, an illegal formation was called on the Patriots forcing them to move back 5-yards. Once again, they went three and out unable to acquire a first down. The Patriots punted and the Broncos began at their own 38. This time, they managed to get a field goal with Brandon McManus's 33-yard kick. They traveled 47-yards in 8 plays and 2:55. The next Patriots drive would once again end in a punt but this time traveling 31 yards on 6 plays. The Broncos received the punt at their own 7. This time, they managed to get to the Patriot's red zone nearly getting into the end zone. Nonetheless, Trevor Siemian was intercepted by Logan Ryan on a pass intended for Emmanuel Sanders. Ryan ran the ball back all the way to the Denver' 46. This was the first play of the second quarter. This time the Patriots managed to get a touchdown in spite of the fact that they had to face a 1st & 20. They first play of the drive ending in a Tom Brady fumble in which Patriot offensive lineman Joe Thuney recovered. The Patriots reached the Broncos' 1 and scored a touchdown with LeGarrette Blount's 1-yard run. The next 2 drives of both teams ended in punts. The Broncos received the ball once more and ended the first half with a run play. The Broncos began with first possession in the beginning of the second half. On their first drive, they went three and out having to punt. Similarly, the Patriots also went three and out. On the next Broncos' possession once again, they were unable to get a first down. The Patriots managed to score on their next drive with Gostkowski's 40-yard field goal. They went 11 plays for 61 yards in 5:12. The next 5 incoming drives all ended in punts. The next few points would come in another Gostkowski field goal at 21-yards. The next 2 drives would end in downs. McCourty stripped Jordan Norwood with a few seconds left to seal the win. Despite just sixteen completions for 188 yards Brady defeated the Broncos for only the third time at Denver and seventh time in his career With the win, the Patriots improved to 12-2, and they clinched a first round bye for the playoffs and the AFC East title for the eighth straight season. Their eighth straight division title surpassed the Rams franchise from 1973-79 for the most consecutive division titles won by one team in NFL history.", "neg": "This game is well known for an infamous penalty that occurred during the overtime period. The Jets were lining up for a game winning 56-yard field goal in overtime to try and give them the win. Nick folk kicked the ball, but the kick went wide right and the Patriots appeared to be taking over with a chance to win. However, Chris Jones of New England was called for a controversial unsportsmanlike conduct penalty after pushing his teammate into the offensive line. This penalty would later be named \"leaping\". The penalty gave the Jets another chance and made the field goal attempt a 51-yard attempt. This time, Folk drilled the kick, and the Jets would go on to stun the Patriots. With the win, the Jets improved to 4-3.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}537{"query": "After dropping their first four games of the season, the Indianapolis Colts came back to Lucas Oil Stadium to take on the Kansas City Chiefs. The game opened well for the Colts, who scored on their opening drive with a Curtis Painter to Pierre Garcon touchdown reception. In the second quarter, the Colts scored with an Adam Vinatieri field goal and another Painter to Garcon touchdown, giving Indianapolis a 17-0 lead midway through the second quarter. A Kansas City touchdown pass from Matt Cassel ended the shutout but Indianapolis scored another touchdown later. A late Kansas City touchdown allowed the Colts to go into halftime with a 24-14 lead. Two touchdown passes from Cassel, to Dwayne Bowe and Steve Breaston respectively, gave the Chiefs 21 unanswered points and completed the comeback, winning the game 28-24, dropping the Colts to 0-5 on the season.", "pos": "The Broncos' defense limited the Chiefs to 279 total yards 133 of which went to tight end Travis Kelce. However, the Broncos were unable to overcome five turnovers, including three interceptions by quarterback Trevor Siemian, as well as a fumble by running back Jamaal Charles that resulted in a Chiefs' touchdown. After trailing 20-3 early in the third quarter, the Broncos narrowed the Chiefs' lead to 20-13, following a 6-yard touchdown by running back Devontae Booker. However, three fourth-quarter field goals by Chiefs' placekicker Harrison Butker the latter two of which occurred after a Broncos' turnover on downs and Siemian's third interception of the game, increased the Chiefs' lead to 29-13. With 4:41 remaining in the game, the Broncos' attempted a rally, with Siemian connecting on an 11-yard touchdown pass to tight end A. J. Derby at the two-minute warning. However, the two-point conversion attempt was unsuccessful, which would have brought the Broncos' to within a one-score deficit, ending the Broncos' rally attempt. This was Jamaal Charles' first game against the Chiefs, for whom he played the first nine seasons of his career.", "neg": "The Indianapolis Colts came into a crucial divisional matchup with the Jacksonville Jaguars, with added importance after the season opening loss to the Texans. With the first possession of the ballgame, the Colts drove down the field with a mix of pass and run plays, scoring the opening touchdown of the game. However, Jacksonville returned the favor by going 76yards to tie the game up, and by the end of the first quarter the game was tied at 7-7. In the second quarter Maurice Jones-Drew scored on a touchdown run giving the Jaguars their first lead of the day, with the Colts eventually responded and tying the up 14-14 going into halftime. With the beginning of the second half both teams failed to score on their next possessions, with the Colts punting to the Jaguars midway through the third quarter. David Garrard threw his first touchdown pass of the day, giving the Jaguars a 21-14 lead towards the end of the third quarter. With the Colts trailing midway through the fourth quarter, Peyton Manning drove the team down the field to score on a Joseph Addai run. With the Jaguars responding and the Colts driving down the field to tie with 0:52 left, the game was a 28-28 with less than thirty seconds in the game. Jacksonville was able to get two big plays on their last drive of the game setting up Josh Scobee for a 59-yard field goal, which was good. The Indianapolis Colts started 0-2 in the AFC South for the first time following this loss, dropping out of first place and falling behind the Houston Texans.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}538{"query": "On July 24, 2017, Gasol re-signed with the Spurs. On December 20, 2017, he had 20 points and a season-high 17 rebounds in a 93-91 win over the Portland Trail Blazers. On December 23, 2017, he recorded his 10th career triple-double with 14 points, 11 rebounds and a season-high 10 assists in a 108-99 win over the Sacramento Kings. On December 26, 2017, in a 109-97 win over the Brooklyn Nets, Gasol collected his 10,817th rebound, moving him past Jack Sikma for 30th in league history. On January 26, 2018, in a 97-78 loss to the Philadelphia 76ers, Gasol became the 34th player in NBA history to play 40,000 career minutes. On March 25, 2018, he had 22 points on 10-of-15 shooting and grabbed 13 rebounds in a 106-103 loss to the Milwaukee Bucks.", "pos": "The Packers' utter dominance continued with another overwhelming performance over another NFC power, the Eagles. Aaron Rodgers broke Tom Brady's mark of 288 passes at home without being intercepted. The Green Bay quarterback set several other records for passing at home, including an NFL-record 29 straight touchdown passes without an interception. The Packers scored touchdowns on all three parts of the team, offense, defense, and special teams. Julius Peppers returned an interception for a touchdown, his second of the year, and Micah Hyde returned a punt for a touchdown. The Packers got going from the very beginning. They drove 75 yards on their opening drive, but had to settle for a 27-yard field goal by Crosby. After an Eagles' punt, the Packers marched on a 13 play, 88-yard drive culminating in a 4-yard touchdown pass to Davante Adams. On the drive, the Packers converted three 3rd-and-longs and took 6:47 off the clock. The Eagles punted again, but this time Micah Hyde returned the punt 75 yards for a touchdown, giving the Packers a shocking 17-0 lead. The Eagles responded on their next possession with a 33-yard field goal by Cody Parkey early in the second quarter. The Eagles, though, had no answer for the Packers' passing game. Rodgers marched the Packers 80 yards in merely 6 plays to increase the lead to 24-3 on a 27-yard touchdown pass to Jordy Nelson. After a punt, the Packers struck again. 80 yards on another time consuming drive ending with Eddie Lacy driving in a 1-yard touchdown run, but a failed two-point conversion. The Eagles reached the Packers' 15, but settled for another 33-yard field goal as the half expired. Mark Sanchez was stripped early in the 3rd quarter with Nick Perry recovering. The Eagles defense finally made a stand and forced a punt, but the Eagles were forced to punt on their responding drive. The Eagles' defense couldn't hold this time and Crosby kicked a 33-yard field goal increasing the lead to 33-6. The Eagles buried themselves on the next drive as Sanchez threw a 52-yard pick-six to Julius Peppers (with a blocked PAT), making the score 39-6. The Eagles immediately answered, driving 80 yards (with a 4th down conversion) with Sanchez throwing a 10-yard touchdown pass to Jordan Matthews. However, the Packers struck right back with an 80yard scoring drive capped off with Rodgers throwing a screen pass to Lacy who took it 32 yards for a touchdown, pushing the lead to 46-13. However, Eagles mishaps continued as Sanchez threw an interception to Tramon Williams, but Crosby missed a field goal. Then on the following drive after reaching the Packers 40, Sanchez fumbled and Hayward returned the fumble 49 yards for a touchdown, making the score a mind boggling 53-13. The Eagles were able to March 80 yards and score on a 20-yard touchdown reception by Jeremy Maclin on their next drive closing the scoring. The Packers achieved a new franchise mark, as this was the first time ever since the franchise started playing in the NFL that they scored over 50 points in consecutive games (the Packers had scored over 50 points in 6 consecutive games as a \"town team\" in 1919, their first season of existence.). Green Bay improved to a record of 7-3.", "neg": "Louis Armstrong had two famous nicknames. Some people called him Bagamo. They said his mouth looked like a large bag. Musicians often called him Pops, as a sign of respect for his influence on the world of music. Born in 1901 in New Orleans, he grew up poor, but lived among great musicians. Jazz was invented in the city a few years before his birth. Armstrong often said,\"Jazz and I grew up together.\" Armstrong showed a great talent for music when he was taught to play the cornet at a boy's home. In his late teens, Armstrong began to live the life of a musician. He played in parades, clubs, and on the steam-boats that travelled on the Mississippi River. At that time, New Orleans was famous for the new music of jazz and was home to many great musicians. Armstrong learned from the older musicians and soon became respected as their equal. In 1922 he went to Chicago. There, the tale of Louis Armstrong begins. From then until the end of his life, Armstrong was celebrated and loved wherever he went. Armstrong had no equal when it came to playing the American popular song. His cornet playing had a deep humanity and warmth that caused many listeners to say,\"Listening to Pops just makes you feel good all over.\"He was the father of the jazz style and also one of the best-known and most-admired people in the world. His death, on July 6 , 1971, was headline news around the world.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}539{"query": "The ESET (also called SETDB1) protein contains an N-terminal tudor domain that mediates protein-protein interactions and a C-terminal SET domain that catalyzes methylation of histone H3 at lysine 9. We report here that ESET protein is transiently upregulated in prehypertrophic chondrocytes in newborn mice. To investigate the in vivo effects of ESET on chondrocyte differentiation, we generated conditional knockout mice to specifically eliminate the catalytic SET domain of ESET protein only in mesenchymal cells. Such deletion of the ESET gene caused acceleration of chondrocyte hypertrophy in both embryos and young animals, depleting chondrocytes that are otherwise available to form epiphyseal plates for endochondral bone growth. ESET-deficient mice are thus characterized by defective long bone growth and trabecular bone formation. To understand the underlying mechanism for ESET regulation of chondrocytes, we carried out co-expression experiments and found that ESET associates with histone deacetylase 4 to bind and inhibit the activity of Runx2, a hypertrophy-promoting transcription factor. Repression of Runx2-mediated gene transactivation by ESET is dependent on its H3-K9 methyltransferase activity as well as its associated histone deacetylase activity. In addition, knockout of ESET is associated with repression of Indian hedgehog gene in pre- and early hypertrophic chondrocytes. Together, these results provide clear evidence that ESET controls hypertrophic differentiation of growth plate chondrocytes and endochondral ossification during embryogenesis and postnatal development.", "pos": "Epigenetic modifications of histones regulate gene expression and chromatin structure. Here we show that Meisetz (meiosis-induced factor containing a PR/SET domain and zinc-finger motif) is a histone methyltransferase that is important for the progression of early meiotic prophase. Meisetz transcripts are detected only in germ cells entering meiotic prophase in female fetal gonads and in postnatal testis. Notably, Meisetz has catalytic activity for trimethylation, but not mono- or dimethylation, of lysine 4 of histone H3, and a transactivation activity that depends on its methylation activity. Mice in which the Meisetz gene is disrupted show sterility in both sexes due to severe impairment of the double-stranded break repair pathway, deficient pairing of homologous chromosomes and impaired sex body formation. In Meisetz-deficient testis, trimethylation of lysine 4 of histone H3 is attenuated and meiotic gene transcription is altered. These findings indicate that meiosis-specific epigenetic events in mammals are crucial for proper meiotic progression.", "neg": "Our previous work has shown that gene knockout of the sodium-glucose cotransporter SGLT2 modestly lowered blood glucose in streptozotocin-diabetic mice (BG; from 470 to 300 mg/dl) and prevented glomerular hyperfiltration but did not attenuate albuminuria or renal growth and inflammation. Here we determined effects of the SGLT2 inhibitor empagliflozin (300 mg/kg of diet for 15 wk; corresponding to 60-80 mgkg(-1)day(-1)) in type 1 diabetic Akita mice that, opposite to streptozotocin-diabetes, upregulate renal SGLT2 expression. Akita diabetes, empagliflozin, and Akita + empagliflozin similarly increased renal membrane SGLT2 expression (by 38-56%) and reduced the expression of SGLT1 (by 33-37%) vs. vehicle-treated wild-type controls (WT). The diabetes-induced changes in SGLT2/SGLT1 protein expression are expected to enhance the BG-lowering potential of SGLT2 inhibition, and empagliflozin strongly lowered BG in Akita (means of 187-237 vs. 517-535 mg/dl in vehicle group; 100-140 mg/dl in WT). Empagliflozin modestly reduced GFR in WT (250 vs. 306 l/min) and completely prevented the diabetes-induced increase in glomerular filtration rate (GFR) (255 vs. 397 l/min). Empagliflozin attenuated increases in kidney weight and urinary albumin/creatinine ratio in Akita in proportion to hyperglycemia. Empagliflozin did not increase urinary glucose/creatinine ratios in Akita, indicating the reduction in filtered glucose balanced the inhibition of glucose reabsorption. Empagliflozin attenuated/prevented the increase in systolic blood pressure, glomerular size, and molecular markers of kidney growth, inflammation, and gluconeogenesis in Akita. We propose that SGLT2 inhibition can lower GFR independent of reducing BG (consistent with the tubular hypothesis of diabetic glomerular hyperfiltration), while attenuation of albuminuria, kidney growth, and inflammation in the early diabetic kidney may mostly be secondary to lower BG.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}540{"query": "When my mother was alive, she used to tell me again and again about the value of just being nice. \"Never underestimate the power of a smile,\" she would say. I fear she would be very disappointed looking at the world today. A lot of people don't smile and when it comes to service today, they're just not nice. Now don't give me wrong, not all service workers but a good many. I was on the phone the other day with a computer help desk. First a man, then later a woman, who couldn't have been ruder. And this to a customer, who didn't know his way around a PC. But no matter, I could tell they thought I was a bother, The woman, in fact, seemed to be chewing gum as she unemotionally clicked off a series of commands for me to perform. The next day I heard from a friend of mine who got a performance review without his boss once looking up at him. Not once. You see it everywhere. Gone are the days when people cared about you. It's a sign of the time, I suspect. But that makes me sad -- for them and for us all. People who aren't happy, who don't smile, who don't kid, who don't joke or make light of even bad situations, make for an even worse situation. And it spreads like a cancer. Someone's rude to you, you're rude to them and to the next fellow you meet, and on and on. Smiles are contagious but so annoyances. The boss who can't be bothered with his workers. The celebrity who can't be bothered with her annoying fans. You know, my mom used to judge presidential candidates by how they smiled. I would say, \"But mom, you don't know if that smile is real.\" \"Oh, yes I do,\" she would tell me. \"I can feel it.\" It's in their eyes, she would say. And it's in their smile. The rest just kind of falls into place.", "pos": "When you enter a crowded room or go on a picnic or to a party, who is the most attractive and appealing person? It is the person who is cheerful, has a smiling face and behaves as if he or she is enjoying every moment of the event! Such people have an optimistic opinion on life. They are the ones with a positive attitude. On the other hand, let's see that fellow in the corner with a long face. He is most probably thinking about the time and money wasted in having fun. He is a pessimist, one with a negative attitude. A person with a positive attitude gets on well with the job at hand. He doesn't worry about what's gone before or what might happen in the future. If there is a problem, he quickly thinks of ways to solve it. If the problem cannot be solved singly, he seeks help from someone else. He doesn't feel that it's beneath his dignity to seek assistance. When Sonal lost her history notes days before an important examination, she sat down and cried. Then she pulled herself together, borrowed a friend's notes, worked day and night and managed to copy down whatever she had lost. Sonal passed the exam with flying color1s. It's just not possible, even for the greatest optimist, to smile all the time and feel good all day. Everyone has a period of blues now and then, when everything seems sad and without cheer. But once you develop a positive attitude, once you realize that life is a series of ups and downs, dark clouds and bright sunshine, in no time at all, you've _ , ready to welcome the world again with open arms and a huge smile! So from this moment on, keep your face to the sunshine and you'll never see the shadows.", "neg": "\"People are ruder today because they are rushed and more 'time poor' than ever before, \" says Patsy Rowe, \" Manners have fallen off the radar . \" Due to our strong attraction to electronic equipment it is a wonder more people don't wake up each morning and greet the singing birds with a complaint about the noise. Here are some examples of rudeness. Some people prefer to do almost everything over the internet. To them, dealing with an actual human is like an evolutionary step backward. It feels very slow because humans don, t work at 4G speeds. When you have dinner with friends, you will often notice someone paying more attention to his mobile phone. We have programmed ourselves to think that every new message brings life-changing news, so taking calls and checking our texts are more important than talking to the people we are with. What is worse, some people even tend to send anonymous rude messages by email. However, rudeness is never acceptable, Don, t assume it is OK to be rude if the person you, re in touch with won, t recognize you. If you have something awful to say, have the courage to face the person and say it, write a letter or email and sign it, or forget it. Upsetting people with unsigned messages is cruel and disgusting. We shouldn't blame technology for our shortcomings. Technology is here to help us, but we should not allow it to take over our lives. An important step is acknowledging our shortcomings. People spend a lot of time pointing out bad manners but it would be even more help if we'd publicly acknowledge good manners when we see them.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}541{"query": "Elis Stromgren's son was the astronomer Bengt Stromgren, who succeeded his father in Copenhagen in 1940.", "pos": "Elisabeth of the Palatinate (26 December 1618 -- 11 February 1680), also known as Elisabeth of Bohemia, Princess Elisabeth of the Palatinate, or Princess-Abbess of Herford Abbey, was the eldest daughter of Frederick V, Elector Palatine (who was briefly King of Bohemia), and Elizabeth Stuart.", "neg": "The first astronomer to record the Butterfly Cluster's existence was Giovanni Battista Hodierna in 1654.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}542{"query": "Rodora is a 1956 movie from Sampaguita Pictures about a man (Juancho Gutierrez) who falls in love with a girl (Amalia Fuentes).", "pos": "Dreams in a Drawer (Italian: I sogni nel cassetto) is a 1957 Italian romantic drama film written and directed by Renato Castellani and starring Lea Massari.", "neg": "Loosely based on the 1967 folk song by Bobbie Gentry, and set in the year 1953 in rural Mississippi, the film explores the budding relationship between 19-year-old Billy Joe McAllister (Robby Benson) and 16-year-old Bobbie Lee Hartley (Glynnis O'Connor) (who corresponds with the unnamed narrator of the original song), despite resistance from Hartley's family, who contend she is too young to date. Yet every day, after being dropped off by her school bus at the Tallahatchie Bridge over the Tallahatchie River which leads to the Hartley farm, Bobbie Lee slips away to a local sawmill where Billy Joe works just to hang out with him at the end of his shift.When Bobbie Lee and her father have a confrontation with three thugs driving a battered pick-up truck from a neighboring county across the state line in Alabama, they chase them to the Tallahatchie where they force their truck off the road which ends up dangling off the bridge. With Bobbie Lee's father unwilling to abandon his truck and abandon the precious eggs and cargo he is delivering to the local market, Bobbie Lee is forced to run several miles to the sawmill to ask Billy Joe, her brother and another employee to rescue her father and save his truck. This incident seem to bring Bobbie Lee and Billy Joe more close to each other.One night at a jamboree, Billy Joe gets drunk and seems nauseated and confused when entering a makeshift whorehouse behind the gathering. Later, Bobbie Lee finds out through the town grapevine that Billy Joe was accused of assaulting one of the prostitutes and is wanted for questioning.After disappearing for days, Billy Joe returns to bid an enigmatic goodbye to Bobbie Lee on the Tallahatchie Bridge. When she presents him with her childhood rag doll, he knocks it away from her and it falls into the river while the passing priest, Brother Taylor, sees from afar. After Billy Joe runs off, Bobbie Lee asks if everything is all right and Billy Joe then blurts out: \"It ain't all right! I have been with a man... which is a sin against nature, a sin against God!\" It is here where he confides in her that on the evening during the jamboree, in his inebriated state, he had sex with another man. Bobbie Lee is somewhat shaken but takes the news very calmly. Overcome with guilt over his homosexual encounter, Billy Joe subsequently kills himself by jumping off the Tallahatchie bridge the next day (off-camera).In the film's final scene, set a few days later after Billy Joe's funeral, Bobbie Lee meets Dewey Barksdale (James Best), Billy Joe's sawmill boss on the bridge as she is leaving town for a while, and he guiltily confesses to her that he was the man whom had sexual relations with Billy Joe that night. She tells Dewey, who is on his way to her house to confess to her father, that the town already falsely suspects that she is carrying Billy Joe's baby and that it would do no good for Dewey to confess now since he could go to prison for sodomy charges. Agreeing with the girl's logic, Dewey offers Bobbie Lee a ride to the bus station, which she courteously accepts.The rest of the story (and song) is history: \"A year has come and gone since we heard the news about Billy Joe. Brother married Becky Thompson and they bought a store in Tupelo. There was a virus goin' around, Papa caught it and he died last spring. And now Mama doesn't wanna do much of anything. And me, I spend a lot of time picking flowers up on Choctaw Ridge and dropping 'em into the muddy waters off the Tallahatchie Bridge.\"", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}543{"query": "As of the census of 2000, there were 120,546 people, 41,668 households, and 32,292 families residing in the county. The population density was 262 people per square mile (101/km). There were 43,903 housing units at an average density of 95 per square mile (37/km). The racial makeup of the county was 68.51% Race (United States Census), 26.06% Race (United States Census) or Race (United States Census), 0.75% Race (United States Census), 1.82% Race (United States Census), 0.06% Race (United States Census), 0.72% from Race (United States Census), and 2.08% from two or more races. 2.26% of the population were Race (United States Census) or Race (United States Census) of any race. 11.6% were of german people, 10.8% irish people, 10.2% english people, 9.3% American and 5.3% italian people ancestry.", "pos": "As of the census of 2000, there were 445,342 people, 169,162 households, and 114,015 families residing in the county. The population density was 615 people per square mile (238/km). There were 178,913 housing units at an average density of 247 per square mile (95/km). The racial makeup of the county was 82.19% Race (United States Census), 1.15% Race (United States Census) or Race (United States Census), 0.65% Race (United States Census), 6.68% Race (United States Census), 0.30% Race (United States Census), 5.86% from Race (United States Census), and 3.17% from two or more races. 11.17% of the population were Race (United States Census) or Race (United States Census) of any race. 17.2% were of German American, 9.9% English American, 8.2% Irish American, and 6.7% Americans ancestry. 81.7% spoke only English at home, while 9.6% spoke Spanish and 1.2% Vietnamese.", "neg": "As of the census of 2000, there were 35,100 people, 12,759 households, and 9,071 families residing in the county. The population density was 59 people per square mile (23/km). There were 15,035 housing units at an average density of 25 per square mile (10/km). The racial makeup of the county was 85.8% Race (United States Census), 3.9% Race (United States Census) or Race (United States Census), 1.8% Race (United States Census), 1.0% Race (United States Census), 0.1% Race (United States Census), 5.0% from Race (United States Census), and 2.4% from two or more races. 8.9% of the population were Race (United States Census) or Race (United States Census) of any race. 14.9% were of German people, 12.6% English people, 11.7% Irish people, 8.8% Italian people and 7.3% United States ancestry according to Census 2000. 93.1% spoke English language and 5.1% Spanish language as their first language.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}544{"query": "The film Calvary is a parable of the betrayal of the Irish people by the Irish Catholic Church.Context for the story: The Irish Catholic Church which was a pillar of, and defined Ireland's soul has been revealed to have consciously and methodically covered up institutional atrocities perpetrated by themselves.Set in rural Ireland, the film begins in a confessional where Father James Lavelle (Brendan Gleeson) is taking confession. The voice on the other side speaks, \"I was seven the first time I tasted semen\". \"Certainly a startling opening line\", Father James replies. The voice asks if he's being ironic. Father James takes a more serious tone. The voice tells him that he was molested both orally and anally by a priest when he was seven and he bled a lot. Father James asks if he would like to report the priest. The voice says that the priest died a long time ago and that it didn't matter. \"Killing a bad priest isn't a big deal, but if you kill a good priest, people take notice\". The voice says he's going to kill Father James in seven days on the beach.James lives a very simple life. He sleeps in a small room with a bed and his only two possessions are his crucifix and his dog. He takes walks on the beach and interacts with the town people. On the beach, he sees his altar server is drawing a landscape. In it there are two figures. James asks who they are and the boy says he doesn't know, but he has been having a lot of dreams about ghosts lately.After mass, Father James is speaking with Father Leary (David Wilmot) who is gossiping about the townsfolk, sharing information he's heard in confession and making racially inappropriate comments about Simon (Isaach De Bankole) the only black man in the town. Father James doesn't say a word about the threat on his life.James' daughter Fiona (Kelly Reilly) comes to town to lay low after a botched suicide attempt. The townsfolk didn't know it was possible for a Catholic priest to have a daughter. James explains that he became a priest after his wife died. The locals in the pub try to flirt with Fiona, but she has no interest. James does not drink. Its not because he doesn't like alcohol. Its because he likes it too much.Later in the day, James visits with Veronica Brennan (Orla ORourke) who was wearing sunglasses during mass to cover up her black eye. She says her husband did it. So James goes to meet her husband, the local butcher Jack Brennan (Chris O'Dowd) and confronts him. Jack is surprised, but good natured about the whole thing. He dismisses his wife by saying she's probably bi-polar. He says it wasn't him, but it might have been her boyfriend Simon. James questions the infidelity, but Jack explains that it works for them. They each do their own thing. James meets with Simon, who takes offense to the charge and passively threatens James and tells him to mind his own business.James spends time with an elderly man known only as The Writer (M. Emmet Walsh) who asks for a Walther PPK, James Bonds favorite gun and the gun Hitler used to kill himself. The Writer explains that he doesn't want to get old and feeble. He'd rather just take his own life when the time is right.James meets with the local Bishop and tells him about the threat during the confession. He also reveals that he knows who the man is and believes the threat is real. The Bishop says that because the man didn't ask for repentance and there was the threat of a law being broken, James would not violate and church law in speaking with the police.James goes to speak with his friend Inspector Stanton (Gary Lydon), who seems to be spending some time with a male prostitute named Leo (Owen Sharpe). Leo keeps making lewd advances on James and offers to have sex with him in his vestments because he knows that's what priests like. Eventually Leo leaves and", "pos": "The film opens on October 30, 1988, nearly ten years after Michael Myers's last murderous rampage in Haddonfield, Illinois. An ambulance from Smith's Grove, IL makes its way along the road in a thunderstorm toward the Ridgemont Federal Sanitarium, where Michael, who has been in a coma since then, has been incarcerated. After the apprehensive transfer crew is seen off by medical chief of staff Dr. Hoffman, the ambulance makes its way up the driveway in the storm and back out onto the highway toward Smith's Grove. While in the ambulance, he hears that eight-year-old Jamie Lloyd, his niece and the daughter of Laurie Strode, his first target, is residing in Haddonfield. He immediately grabs and repeatedly bashes a hospital attendant's head against the wall of the ambulance and stabs his finger right into his skull. The other attendant, trapped by the ambulance's locked doors, can only watch helplessly. Soon after, the film introduces Jamie, who has been adopted by the Carruthers family and is still mourning the loss of her mother. Laurie supposedly died in a car accident eleven months earlier. Her older foster sister Rachel comes into her room and consoles her, telling her that she will love her just as much as her mother did. Rachel sends Jamie off to bed and exits the room. Jamie kneels down next to the bed and says her prayers when suddenly, lightning and thunder crash outside, startling her. The door creaks open and as Jamie gets up to close it, the reflection of Michael, donned in his classic white mask and black coveralls, appears in the mirror. Jamie returns to her bed and instantly, Michael's hand reaches out from under the bed and grabs her by the leg. Jamie struggles, gets loose, and runs to her closet. Opening the door, a second Michael appears in front of her, raising his knife. Jamie screams again, attracting the attention of her foster mother, Darlene, who rushes into the room. She finds Jamie, shaking on the floor of her closet, traumatized after what was only a horrific nightmare.Dr. Loomis angrily marches into Hoffman's office the next day, berating him about the transfer of Michael Myers. Hoffman explains that it was mandated by federal law; as he does, he is interrupted by a phone call informing him of an accident involving the ambulance that was carrying Michael Myers. Immediately Loomis smells trouble, and the two men drive to the site of the accident. The state police have secured the scene; the ambulance is upside-down in a river with blood on both the outside & interior. One trooper tells Hoffman it was likely an accident, but Loomis does not believe it. Despite Hoffman's admonishments, Loomis wades into the river & walks round to the ambulance's rear. Inside is a scene of horror; blood is sprayed all over the walls & floor of the ambulance. Immediately, Loomis heads toward Haddonfield, certain that Michael Myers is headed there. Meanwhile, at a gas station, a mechanic works beneath a car, calling for someone to hand him a wrench. When he hears no response, he slides out. There is Michael, raising a long, sharp pole in the air. He thrusts it down into the mechanic's stomach, killing him instantly. Loomis soon after arrives at the gas station and finds the mechanic's body, hanging by a chain from the roof. He also finds several other bodies and immediately sees Michael, standing against the back wall. Loomis shoots at him, but Michael disappears. Loomis scurries out to the exterior of the gas station, barely catching Michael driving away in a truck. Just after, the entire gas station explodes. Loomis survives after crouching behind a nearby barrel.Meanwhile, Jamie is coming home from school to see several kids coming upon her, taunting her that she has no mother. Jamie runs from the scene, crying. At home, Rachel plans to go out for Halloween with her boyfriend, Brady, but her parents refuse and force her to take Jamie trick-or-treating. Rachel protests and Jamie overhears, upset at the fact that Rachel", "neg": "Two white racists, Billy Ray Cobb (Nicky Katt) and Pete Willard (Doug Hutchison), come across a 10-year-old black girl named Tonya Hailey (Rae'Ven Larrymore Kelly) in rural Mississippi. They violently rape and beat Tonya and dump her in a nearby river after a failed attempt to hang her. She survives, and the men are arrested.Tonya's father, Carl Lee Hailey (Samuel L. Jackson), seeks out Jake Brigance (Matthew McConaughey), an easygoing white lawyer. Carl Lee is worried that the men may be acquitted due to deep-seated racism in the Mississippi Delta area. They discuss a similar case further south in which four white teenagers were acquitted of the rape of a black girl. Brigance admits the possibility that the rapists will walk free in this case as well. Carl Lee acquires an M16 rifle, goes to the county courthouse and opens fire. This results in the deaths of both rapists and also in the unintended injury of Deputy Looney (Chris Cooper), who has to have his leg amputated. Carl Lee is soon arrested without resistance. Brigance agrees to provide defense for Carl Lee for a much smaller amount of money than such a trial would usually require. He intends to enter a plea of not guilty by reason of temporary insanity.The rape and subsequent revenge killing gain national media attention. The Ku Klux Klan begins to organize in the area. Freddie Lee Cobb (Kiefer Sutherland), the brother of Billy Ray, calls Brigance and his family with death threats and organizes the formation of a Klan chapter in the county. The district attorney, Rufus Buckley (Kevin Spacey), decides to seek the death penalty, and presiding Judge Omar Noose (Patrick McGoohan) denies Brigance a change of venue. Brigance seeks help for his defense team from sleazy divorce lawyer and close friend Harry Rex Vonner (Oliver Platt). He seeks guidance from long-time liberal activist Lucien Wilbanks (Donald Sutherland), a once-great civil rights lawyer who was disbarred for violence on a picket line.Brigance is approached by Ellen Roark (Sandra Bullock), a fiery liberal law student from Massachusetts who belongs to the ACLU. Brigance is initially reluctant to accept Ellen's cooperation, but he later agrees to let her help with the case. The trial begins amid much attention from the media and public. The Klan, which has a member inside the sheriff's department, burns a cross on Brigance's lawn. This incident causes an argument between Brigance and his wife to the effect that if Jake had heeded Carl Lee's warning, this would not have happened. The police evacuate Jake's family from their house. Brigance and the police capture one of the Klan members, and they find a case with a bomb inside it. Brigance throws the bomb into the air, where it explodes. This motivates Jake to send his wife and young daughter away while the trial continues.As the trial begins, the KKK march down Canton's streets and meet a large group of mostly black protesters at the courthouse. Chaos ensues outside the courthouse as the police lose control of the crowd. A black teenager kills the KKK Grand Dragon (Kurtwood Smith) with a Molotov cocktail, burning him to death. Brigance's attraction to Roark grows, and they nearly begin an affair before Brigance regains his wits. He goes home, finding that arsonists have burned down his house, nearly killing his dog Max in the process. The next morning, as the Mississippi National Guard is called in to take care of the rioting, Brigance sits on the still-smoking steps of his house, calling for his dog. Harry Rex arrives at the remains of the Brigance home and tells Jake that it is time to quit the case. Brigance argues that to quit now would make his sacrifices meaningless. The jury secretly discusses the case in a restaurant, going against the judge's instructions. All but one are leaning toward a guilty verdict and Carl Lee's fate looks sealed.Freddie Lee Cobb shoots at Brigance as he exits the courthouse, but misses. The bullet hits a national guardsman policing the demonstrations, paralyzing him. Roark is kidnapped by", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}545{"query": "Chronic myeloid leukaemia (CML) is characterized cytogenetically by a t(9;22)(q34;ql1) reciprocal translocation which gives origin to a hybrid BCR-ABL gene, encoding a p2lO(BCR-ABL) fusion protein with elevated tyrosine kinase activity and transforming abilities. The t(9;22) was suggested to be associated with genomic imprinting of centromeric regions of chromosomes 9 and 22, but the genes directly affected by the translocation, ABL and BCR, were shown not to be imprinted. For most diagnostic and research purposes the BCR-ABL gene can be efficiently identified by reverse-transcription and polymerase chain reaction (RT/PCR) amplification of its fusion transcripts, which can be quantified by competitive PCR and similar assays for assessment of residual disease in the follow-up of therapy. In the great majority of CML patients the BCR-ABL transcripts exhibit a b2a2 and/or a b3a2 junction; in rare cases, the only detectable BCR-ABL transcripts have unusual junctions, such as b2a3, b3a3, e1a2 or e6a2. There is a recent suggestion that the BCR-ABL gene may not be always 'functional', since extremely low levels of BCR-ABL transcripts can be found in leucocytes from normal individuals and, conversely, it appears that no BCR-ABL transcription can be detected in a proportion of Ph-positive haematopoietic progenitors from some CML patients. The role, if any, of the reciprocal ABL-BCR hybrid gene in CML is unknown. Although its mRNA message is in frame, no ABL-BCR fusion protein has yet been identified in CML patients. The blast crisis of CML has been variably associated with abnormalities of proto-oncogenes, such as RAS and MYC, or of tumour suppressor genes, in particular RB, p53 and p16, or with the generation of chimeric transcription factors, as in the AML1-EVI1 gene fusion. It is likely, therefore, that multiple and alternative molecular defects, as opposed to a single universal mechanism, underlie the acute transformation of the disease.", "pos": "The t(9;22)(q34;q11) translocation leading to the Philadelphia (Ph) chromosome resulting in BCR-ABL gene fusion is associated with a poor prognosis in acute lymphoblastic leukemia (ALL). We studied the relation between t(9;22), determined by karyotype, fluorescence in situ hybridization (FISH) or polymerase chain reaction (PCR), and in vitro drug resistance, measured by the MTT assay, in precursor B-cell ALL at diagnosis. The findings in twenty-one Ph-positive (Ph+) childhood common/precursorB (c/preB) cases were compared with 254 Ph-negative (Ph-) ALL cases. A large range of LC(50) values was found within the Ph+ patients. Moreover, LC(50) values did not differ significantly between Ph+ and Ph- samples for prednisolone, dexamethasone, L-asparaginase, vincristine, anthracyclines, thiopurines, epipodophyllotoxins, and 4H00-ifosfamide, even after matching for important prognostic features (age, white blood cell count (WBC), and immunophenotype). Adult Ph+ (n = 12) ALL was more resistant to prednisolone (> 270-fold, P = 0.030), and displayed an overall tendency to resistance when compared to matched cases of Ph- (n = 15) adult precursor B-cell ALL. Within Ph+ ALL, in vitro prednisolone resistance increased significantly with age (P = 0.006). The expression of lung resistance protein (LRP), but not P-glycoprotein (P-gp) or multidrug resistance protein (MRP), was significantly higher in all Ph+ patients. Both childhood and adult Ph+ precursor B-cell ALL samples display a heterogeneous in vitro resistance profile, with relatively sensitive and resistant cases. The adult Ph+ samples, however, are generally more resistant compared to matched Ph- controls, reaching significance for prednisolone. The correlation of prednisolone resistance with age within the Ph+ cases might help explain the poorer prognosis of adult Ph+ ALL.", "neg": "In chronic lymphocytic leukemia (CLL) signals from the B cell receptor (BCR) play a major role in disease development and progression. In this light, new therapies that specifically target signaling molecules downstream of the BCR continue to be developed. While first studies on the selective small molecule inhibitor of Bruton's tyrosine kinase (Btk), Ibrutinib (PCI-32765), demonstrated that Btk inhibition sensitizes CLL cells to apoptosis and alters their migratory behavior, these studies however did not address whether Btk-mediated signaling is involved in the process of CLL leukemogenesis. To investigate the requirement of Btk signaling for CLL development, we modulated Btk expression in the IgH.ET CLL mouse model, which is based on sporadic expression of the simian oncovirus SV40 T-antigen in mature B cells. To this end, we crossed IgH.ET mice on a Btk-deficient background or introduced a human Btk transgene (CD19-hBtk). Here we show that Btk deficiency fully abrogates CLL formation in IgH.ET mice, and that leukemias formed in Btk haplo-insufficient mice selectively expressed the wild-type Btk allele on their active X chromosome. Conversely, Btk overexpression accelerated CLL onset, increased mortality, and was associated with selection of non-stereotypical BCRs into CLL clones. Taken together, these data show that Btk expression represents an absolute prerequisite for CLL development and that Btk mediated signaling enhances leukemogenesis in mice. We therefore conclude that in CLL Btk expression levels set the threshold for malignant transformation.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}546{"query": "How fast or slow something moves is its speed. Speed determines how far something travels in a given amount of time. The SI unit for speed is meters per second (m/s). Speed may be constant, but often it varies from moment to moment. Even if speed varies during the course of a trip, its easy to calculate the average speed by using this formula: speed = distance time For example, assume you go on a car trip with your family. The total distance you travel is 120 miles, and it takes 3 hours to travel that far. The average speed for the trip is: 120 mi 3h = 40 mi/h speed = Q: Terri rode her bike very slowly to the top of a big hill. Then she coasted back down the hill at a much faster speed. The distance from the bottom to the top of the hill is 3 kilometers. It took Terri 41 hour to make the round trip. What was her average speed for the entire trip? (Hint: The round-trip distance is 6 km.) A: Terris speed can be calculated as follows: 6 km 0.25 h = 24 km/h speed = When you travel by car, you usually dont move at a constant speed. Instead you go faster or slower depending on speed limits, traffic lights, the number of vehicles on the road, and other factors. For example, you might travel 65 miles per hour on a highway but only 20 miles per hour on a city street (see the pictures in the Figure 1.1.) You might come to a complete stop at traffic lights, slow down as you turn corners, and speed up to pass other cars. Therefore, your speed at any given instant, or your instantaneous speed, may be very different than your speed at other times. Instantaneous speed is much more difficult to calculate than average speed. Cars race by in a blur of motion on an open highway but crawl at a snails pace when they hit city traffic. If you know the average speed of a moving object, you can calculate the distance it will travel in a given period of time or the time it will take to travel a given distance. To calculate distance from speed and time, use this version of the average speed formula given above: distance = speed time For example, if a car travels at an average speed of 60 km/h for 5 hours, then the distance it travels is: distance = 60 km/h 5 h = 300 km To calculate time from speed and distance, use this version of the formula: time = distance speed Q: If you walk 6 km at an average speed of 3 km/h, how much time does it take? A: Use the formula for time as follows: distance speed 6 km = 3 km/h =2h time =", "pos": "Speed is an important aspect of motion. It is a measure of how fast or slow something moves. It depends on how far something travels and how long it takes to travel that far. Speed can be calculated using this general formula: speed = distance time A familiar example is the speed of a car. In the U.S., this is usually expressed in miles per hour (see Figure 12.6). If your family makes a car trip that covers 120 miles and takes 3 hours, then the cars speed is: speed = 120 mi = 40 mi/h 3h The speed of a car may also be expressed in kilometers per hour (km/h). The SI unit for speed is meters per second (m/s). When you travel by car, you usually dont move at a constant speed. Instead you go faster or slower depending on speed limits, traffic, traffic lights, and many other factors. For example, you might travel 65 miles per hour on a highway but only 20 miles per hour on a city street (see Figure 12.7). You might come to a complete stop at traffic lights, slow down as you turn corners, and speed up to pass other cars. The speed of a moving car or other object at a given instant is called its instantaneous speed. It may vary from moment to moment, so it is hard to calculate. Its easier to calculate the average speed of a moving object than the instantaneous speed. The average speed is the total distance traveled divided by the total time it took to travel that distance. To calculate the average speed, you can use the general formula for speed that was given above. Suppose, for example, that you took a 75-mile car trip with your family. Your instantaneous speed would vary throughout the trip. If the trip took a total of 1.5 hours, your average speed for the trip would be: average speed = 75 mi = 50 mi/h 1.5 h You can see a video about instantaneous and average speed and how to calculate them at this URL: MEDIA Click image to the left or use the URL below. URL: You Try It! Problem: Terri rode her bike very slowly to the top of a big hill. Then she coasted back down the hill at a much faster speed. The distance from the bottom to the top of the hill is 3 kilometers. It took Terri 15 minutes to make the round trip. What was her average speed for the entire trip? The motion of an object can be represented by a distance-time graph like the one in Figure 12.8. A distance-time graph shows how the distance from the starting point changes over time. The graph in Figure 12.8 represents a bike trip. The trip began at 7:30 AM (A) and ended at 12:30 PM (F). The rider traveled from the starting point to a destination and then returned to the starting point again. In a distance-time graph, the speed of the object is represented by the slope, or steepness, of the graph line. If the line is straight, like the line between A and B in Figure 12.8, then the speed is constant. The average speed can be calculated from the graph. The change in distance (represented by Dd) divided by the change in time (represented by Dt): speed = Dd Dt For example, the speed between A and B in Figure 12.8 is: speed = Dd 20 km 0 km 20 km = = = 20 km/h Dt 8:30 7:30 h 1h If the graph line is horizontal, as it is between B and C, then the slope and the speed are zero: speed = Dd 20 km 20 km 0 km = = = 0 km/h Dt 9:00 8:30 h 0.5 h You Try It! Problem: In Figure 12.8, calculate the speed of the rider between C and D. If you know the speed of a moving object, you can also calculate the distance it will travel in a given amount of time. To do so, you would use this version of the general speed formula:", "neg": "Driving In America Keep Right The traffic follows the \"keep right rule\". While driving, drive on the right side of the road. On one-way, multiple lanes road, the right-most lane would be slowest and left-most lane is fastest. Hand Signals Though indicators are used for the purpose of showing which direction you are going, knowing some hand signals is very important and are usually always asked in a driving test. When you want to turn right, you can put your left hand out of the window and point upward. When you want to make a left turn, you can reach your left arm out of the window and point to the left. If you want to slow down or stop, you can just point downward. School Buses Yellow school buses have flashing red lights and stop signs that reach out from the driver's side. The drivers use these warning signals when letting pupils on and off. No matter which side of the road you are traveling on, if you come upon a school bus with its lights flashing and a stop sign used, you must stop. It's the law. Remain stopped until the lights stop flashing or the stop sign is removed. Using the Horn Using horns is not common in America. Actually they are very rarely used. You may use your horn to warn walkers or other drivers of possible trouble or to avoid accidents. Do not use your horn to express anger or complain about other drivers' mistakes or to try to get a slow driver to move faster.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}547{"query": "Extrusive igneous rocks cool at the surface. Volcanoes are one type of feature that forms from extrusive rocks. Several other interesting landforms are also extrusive features. Intrusive igneous rocks cool below the surface. These rocks do not always remain hidden. Rocks that formed in the crust are exposed when the rock and sediment that covers them is eroded away. When lava is thick, it flows slowly. If thick lava makes it to the surface, it cannot flow far from the vent. It often stays right in the middle of a crater at the top of a volcano. Here the lava creates a large, round lava dome (Figure A lava plateau is made of a large amount of fluid lava. The lava flows over a large area and cools. This creates a large, flat surface of igneous rock. Lava plateaus may be huge. The Columbia Plateau covers over 161,000 square kilometers (63,000 square miles). It makes up parts of the states of Washington, Oregon, and Idaho. Thin, fluid lava created the rock that makes up the entire ocean floor. This is from multiple eruptions from vents at the mid-ocean ridge. While not exactly a lava plateau, its interesting to think about so much lava! New land is created in volcanic eruptions. The Hawaiian Islands are shield volcanoes. These volcanoes formed from fluid lava (Figure 8.21). The island grows as lava is added on the coast. New land may also emerge from lava that erupts from beneath the water. This is one way that new land is created. Magma that cools underground forms intrusions (Figure 8.22). Intrusions become land formations if they are exposed at the surface by erosion. Water works its way through porous rocks or soil. Sometimes this water is heated by nearby magma. If the water makes its way to the surface, it forms a hot spring or a geyser. When hot water gently rises to the surface, it creates a hot spring. A hot spring forms where a crack in the Earth allows water to reach the surface after being heated underground. Many hot springs are used by people as natural hot tubs. Some people believe that hot springs can cure illnesses. Hot springs are found all over the world, even in Antarctica! Geysers are also created by water that is heated beneath the Earths surface. The water may become superheated by magma. It becomes trapped in a narrow passageway. The heat and pressure build as more water is added. When the pressure is too much, the superheated water bursts out onto the surface. This is a geyser. There are only a few areas in the world where the conditions are right for the formation of geysers. Only about 1,000 geysers exist worldwide. About half of them are in the United States. The most famous geyser is Old Faithful at Yellowstone National Park (Figure 8.23). It is rare for a geyser to erupt so regularly, which is why Old Faithful is famous.", "pos": "You are on vacation at the beach. You take your flip-flops off so you can go swimming. The sand is so hot it hurts your feet. You have to run to the water. Now imagine if it were hot enough for the sand to melt. Some places inside Earth are so hot that rock melts. Melted rock inside the Earth is called magma. Magma can be hotter than 1,000C. When magma erupts onto Earths surface, it is known as lava, as Figure 3.17 shows. Minerals form when magma and lava cool. Most water on Earth, like the water in the oceans, contains elements. The elements are mixed evenly through the water. Water plus other substances makes a solution. The particles are so small that they will not come out when you filter the water. But the elements in water can form solid mineral deposits. Fresh water contains a small amount of dissolved elements. Salt water contains a lot more dissolved elements. Water can only hold a certain amount of dissolved substances. When the water evaporates, it leaves behind a solid layer of minerals, as Figure 3.18 shows. At this time, the particles come together to form minerals. These solids sink to the bottom. The amount of mineral formed is the same as the amount dissolved in the water. Seawater is salty enough for minerals to precipitate as solids. Some lakes, such as Mono Lake in California, or Utahs Great Salt Lake, can also precipitate salts. Salt easily precipitates out of water, as does calcite, as Figure 3.19 shows. The limestone towers in the figure are made mostly of the mineral calcite. The calcite was deposited in the salty and alkaline water of Mono Lake, in California. Calcium-rich spring water enters the bottom of the lake. The water bubbles up into the alkaline lake. The Underground water can be heated by magma. The hot water moves through cracks below Earths surface. Hot water can hold more dissolved particles than cold water. The hot, salty solution has chemical reactions with the rocks around it. The water picks up more dissolved particles. As it flows through open spaces in rocks, the water deposits solid minerals. When a mineral fills cracks in rocks, the deposits are called veins. Figure 3.20 shows a white quartz vein. When the minerals are deposited in open spaces, large crystals grow. These rocks are called geodes. Figure 3.20 shows a geode that was formed when amethyst crystals grew in an open space in a rock.", "neg": "The most obvious landforms created by lava are volcanoes, most commonly as cinder cones, composite volcanoes, and shield volcanoes. Eruptions also take place through other types of vents, commonly from fissures (Figure 1.1). The eruptions that created the entire ocean floor are essentially fissure eruptions. Viscous lava flows slowly. If there is not enough magma or enough pressure to create an explosive eruption, the magma may form a lava dome. Because it is so thick, the lava does not flow far from the vent. (Figure 1.2). Lava flows often make mounds right in the middle of craters at the top of volcanoes, as seen in the Figure 1.3. A fissure eruption on Mauna Loa in Hawaii travels toward Mauna Kea on the Big Is- land. Lava domes are large, round landforms created by thick lava that does not travel far from the vent. Lava domes may form in the crater of composite volcanoes as at Mount St. He- lens. A lava plateau forms when large amounts of fluid lava flow over an extensive area (Figure 1.4). When the lava solidifies, it creates a large, flat surface of igneous rock. Layer upon layer of basalt have created the Columbia Plateau, which covers more than 161,000 square kilometers (63,000 square miles) in Washington, Oregon, and Idaho. Lava creates new land as it solidifies on the coast or emerges from beneath the water (Figure 1.5). Lava flowing into the sea creates new land in Hawaii. Over time the eruptions can create whole islands. The Hawaiian Islands are formed from shield volcano eruptions that have grown over the last 5 million years (Figure 1.6). The island of Hawaii was created by hotspot volcanism. You can see some of the volcanoes (both active and extinct) in this mosaic of false-color composite satellite images. Magma intrusions can create landforms. Shiprock in New Mexico is the neck of an old volcano that has eroded away (Figure 1.7). The volcanic neck is the remnant of the conduit the magma traveled up to feed an eruption. The aptly named Shiprock in New Mexico.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}548{"query": "The Godfather Part II presents two parallel storylines. One involves Mafia chief Michael Corleone in 1958/1959 after the events of the first movie; the other is a series of flashbacks following his father, Vito Corleone from 1917 to 1925, from his youth in Sicily (1901) to the founding of the Corleone family in New York.The film begins in 1901, in the town of Corleone, Sicily, at the funeral of young Vito's father, Antonio Andolini, who has been murdered for an insult to the local Mafia lord, Don Ciccio. During the procession, Vito's older brother is murdered because he swore revenge on the Don. Vito's mother goes to Ciccio to beg for mercy, but he refuses, knowing that nine-year-old Vito will seek revenge later in life. The mother takes Ciccio hostage at knifepoint, allowing her son to escape, and Ciccio's men kill her. They search the town for the boy, but he is aided in his escape by the townspeople. Vito finds his way by ship to New York, and at Ellis Island an immigration agent chooses Vito's hometown of Corleone as his surname, and he is registered as \"Vito Corleone\".In 1958 in a scene similar to the opening of the first film, Michael Corleone (Al Pacino), Godfather of the Corleone family, deals with various business and family problems during an elaborate party at his Lake Tahoe, Nevada compound to celebrate his son's First Communion. In his office, Michael meets with corrupt Nevada Senator Pat Geary (G. D. Spradlin) to discuss the price of the gaming licenses for the hotel/casinos the Family is buying. Geary, who has obvious contempt for Michael and other Italian businessmen who are moving into his state to take advantage of gambling opportunities, promises to make Michael's acquisition of his gaming license a difficult process. Michael ends his conversation with Geary when he refuses to pay the outrageous fee Geary demands, telling the senator he'll get nothing.Michael also deals with his self-indulgent younger sister Connie (Talia Shire), who, although recently divorced from her second husband, is planning to marry a man named Merl Johnson (Troy Donahue) with no obvious means of support and of whom Michael disapproves. He also talks with Johnny Ola (Dominic Chianese), the right hand man of Jewish gangster Hyman Roth (Lee Strasberg), who is supporting Michael's move into the gambling industry. Belatedly, Michael deals with Frank \"Five Angels\" Pentangeli (Michael V. Gazzo), a business associate who took over Corleone caporegime Peter Clemenza's territory in New York City after his death, and now has problems with the Rosato Brothers, who are backed by Roth. Pentangeli leaves abruptly, after telling Michael \"your father did business with Hyman Roth, your father respected Hyman Roth, but your father never trusted Hyman Roth.\"Later that night, Michael barely escapes an assassination attempt when his wife Kay (Diane Keaton) notices the bedroom window drapes are inexplicably open, which allows two unseen hitmen to spray the bedroom with bullets. The two hitman are found dead having been killed by a \"mole\" within the compound. Afterwards, Michael tells his lawyer and associate Tom Hagen (Robert Duvall) that the hit was made with the help of someone close, and that he must leave, entrusting all his power to Hagen to protect his family.Flashback: In 1917 New York City, the adult Vito Corleone (Robert De Niro) works in a grocery store in the Lower East side with his friend Genco Abbandando. The neighborhood is controlled by a member of the \"The Black Hand,\" Don Fanucci (Gastone Moschin), who extorts protection payments from local businesses. One night, Vito's neighbor Clemenza (Bruno Kirby) asks him to hide a stash of guns for him, and later, to repay the favor, takes him to a fancy apartment where they commit their first felony together, stealing an elegant rug.The film flash-forwards to Michael's time. Michael meets with poushal Hyman Roth in Miami, Florida who tells Michael that he believes Frank Pentangeli was responsible for the assassination attempt, and that Pentangeli will pay for it", "pos": "Police officers Brian Taylor (Jake Gyllenhall) and Mike Zavala (Michael Pena) are close friends and partners in the Los Angeles Police Department. Taylor is filming their police activities for a film project, attaching small cameras to his and Zavala's uniforms and carrying around a camcorder, much to the dismay of their peers and superiors. After shooting two suspects following a high speed chase, the shooting is declared justified by the D.A. and the officers are commended for their actions. Taylor and Zavala's antics are met with scorn by fellow officer Van Hauser (David Harbour).The officers respond to a call regarding a man, Mr. Tre (Cle Shaheed Sloan) scaring off a mailman while intoxicated. Upon arrival, Tre hurls racist insults at the Hispanic Zavala, who responds by accepting a fight, to Taylor's approval. Zavala beats him soundly and arrests him, but wins the man's respect for both fighting fair and not mentioning the fight in the report (which may have sent Tre to prison for life due to Three Strikes). Later that night, Tre and his friends are shot at by a group of Latino gang members and one of his friends is killed. The officers find the now-burnt vehicle used in the drive-by the next day, but are shooed off the scene by homicide detectives as well as Van Hauser, who warns them they will get screwed over by the LAPD someday.Responding to a missing persons report, the officers discover two children bound and locked away in a closet and arrest the distressed mother and her drug-addict husband.The cops arrive as a group at a loud outdoor party, the Hispanics from the drive by shooting are celebrating. The cops and partiers verbally joust and Brian sizes up the gang leader, Big Evil (Maurice Compte). The cops depart telling them to keep the noise down.Taylor begins dating Janet (Anna Kendrick) and feels Janet is the only girl he's dated who can connect with him on an intellectual level. Zavala, who is married and expecting a child, offers him relationship advice.Investigating the South Central area, Taylor has a hunch and determines to scope out the home of the mother of a known gang member and sees an expensive pick up truck in the driveway. A woman walks out of the house and delivers a large soup saucepan with lid to the man in the truck. As the truck drives away, the officers follow and then pull over the man in the truck, ostensibly for having CD hanging off the mirror and illegally obstructing the front view, which is minor traffic violation in California per VC 26708 . As Zavala approaches the driver's window to make contact, the driver suddenly draws a gun and fires, and Zavala deflects the man's arm just in time to avoid being shot. After arresting the driver, the officers find an ornately-decorated, compact .45 Colt automatic pistol, a gold-plated AK-47 rifle, and a large amount of money in his truck (hidden in the soup pot). As revealed later, the money and firearms are connected to a Mexican drug cartel operation in the South Central area as well as the gang that did the drive-by on Tre and others.Days later, the two officers are first responders at a house fire that has trapped children on the second floor. Zavala and Taylor enter the house and rescue two young children and are nearly overcome by heat and smoke. When the mother informs them that a third child remains inside, Zavala to rushes to the aid of the remaining child as Taylor reluctantly follows, barely making it out alive. The two are commended and receive the Medal of Valor for their actions, but Taylor has mixed emotions about the situation. Using the house fire incident as leverage, Taylor convinces Zavala to further investigate the South Central incident, to Zavala's chagrin. Arriving at the house, Taylor and Zavala notice suspicious behavior from outside and enter. They arrest another man, who is also in possession of several ornate firearms: a .45 Colt automatic similar to the first one found at the traffic stop, and a Walther PPK. Investigating further, Taylor discovers a hidden stash of Mexican and Asian", "neg": "Early one morning, a taxi pulls up at Tiffany & Co. on Fifth Avenue in New York City, from which elegantly dressed Holly Golightly (Audrey Hepburn) emerges. After looking into the shop's windows, she strolls home. Outside her apartment, she fends off Sid Arbuck (Claude Stroud), her date from the disastrous night before. Later, she is awakened by new neighbor Paul Varjak (George Peppard), ringing her doorbell to get into the building. The pair chat as she dresses to leave for her weekly visit to Sally Tomato (Alan Reed), a mobster incarcerated at Sing Sing prison. Tomato's lawyer, O'Shaughnessy, pays her $100 a week to deliver \"the weather report\". Audrey Hepburn as Holly Golightly As she is leaving for Sing Sing, Holly is introduced to Paul's \"decorator\", wealthy older woman Emily Eustace Failenson (Patricia Neal), whom Paul nicknames \"2E\". That night, Holly goes out onto the fire escape to elude an over-eager date (Mel Blanc). She peeks into Paul's apartment and sees 2E leaving money and kissing Paul goodbye. After 2E leaves, Holly enters Paul's apartment and learns that he is a writer who has not had anything published since a book of vignettes five years before. Holly, in turn, explains that she is trying to save money to support her brother Fred when he gets out of the Army. The pair fall asleep, but are awakened when Holly has a nightmare about Fred. She later buys Paul a typewriter ribbon to apologize and invites him to a party at her apartment. There, Paul meets her Hollywood agent, O. J. Berman (Martin Balsam), who describes Holly's transformation from country girl into Manhattan socialite. He is also introduced to Jose da Silva Pereira (Jose Luis de Vilallonga), a wealthy Brazilian politician, and Rusty Trawler (Stanley Adams), the \"ninth richest man in America under 50.\" In the days that follow, Paul and Holly become closer. One day, 2E enters Paul's apartment, worried that she is being followed. Paul tells her that he will investigate and eventually confronts Doc Golightly (Buddy Ebsen), Holly's estranged husband. Doc explains that Holly's real name is Lula Mae Barnes. They married when she was 13, and he wants to take her back to Texas, as Fred will be returning. After Paul reunites Holly and Doc, she tells Paul the marriage was annulled. At the bus station, she tells Doc she is not going with him. Doc leaves broken-hearted. After drinking at a club, Paul and Holly return to her apartment, where she drunkenly tells him that she plans to marry Trawler for his money. A few days later, Paul learns that one of his short stories will be published. On the way to tell Holly, he sees a newspaper headline stating that Trawler has married someone else. Holly and Paul agree to spend the day together, taking turns doing things that each has never done before. At Tiffany's, Paul has the ring from Doc Golightly's box of Cracker Jack engraved as a present for Holly. After spending the night together, he awakens to find her gone. When 2E arrives, Paul ends their relationship. She calmly accepts, having earlier concluded that he and Holly are in love. Holly schemes to marry Jose for his money, which angers Paul. After Holly receives a telegram notifying her of Fred's death, she trashes her apartment. Months later, Paul has moved out. He is invited to dinner by Holly, who is leaving the next morning for Brazil to continue her relationship with Jose. However, they are arrested in connection with Sally Tomato's drug ring, and Holly spends the night in jail. The next morning, Holly is released on bail and finds Paul waiting, and they take a cab. He has her cat and a letter from Jose explaining he must end their relationship due to her arrest. Holly insists she will go to Brazil anyway, asks the cab to pull over, and releases the", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}549{"query": "Shprintzen-Goldberg syndrome is one of a group of disorders characterized by craniosynostosis and marfanoid habitus. Eleven cases were reported previously. We present 4 new patients and review one of the patients of the original report of Shprintzen and Goldberg [1982: J Craniofac Genet Dev Biol 2:65-74], 15 years later. The clinical and radiologic findings on our patients are compared with those of the previously reported patients and also with those of Furlong et al. [1987: Am J Med Genet 26:599-604] and Lacombe and Battin [1993: Clin Dysmorphol 2: 220-224], who share many of the characteristics of Shprintzen-Goldberg syndrome. Some of the clinical data are helpful in determining if the patients of Furlong et al. [1987: Am J Med Genet 26:599-604] and Lacombe and Battin [1993: Clin Dysmorphol 2: 220-224] have a separate syndrome or represent a variant of Shprintzen-Goldberg syndrome. However, radiologic investigations appear to be more specific, since an abnormality of the first and second cervical vertebrae, hydrocephalus, dilatation of the lateral ventricles, and a Chiari-I malformation of the brain were found only in the patients with Shprintzen-Goldberg syndrome. The apparently diagnostic findings of the 15 patients with this syndrome may be helpful in differentiating between Shprintzen-Goldberg syndrome and other syndromes with craniosynostosis and marfanoid habitus.", "pos": "Shprintzen-Goldberg syndrome (SGS) is characterized by craniosynostosis and marfanoid habitus. The clinical findings of SGS include neurological, cardiovascular, connective tissue, and skeletal abnormalities. Among these skeletal findings, developmental scoliosis is recognized in half of all patients with SGS. However, no earlier reports have described the surgical treatment of scoliosis associated with SGS. Four patients (2 boys and 2 girls; mean age at the time of surgery, 7.34.4 y) with SGS who underwent surgical treatment for progressive scoliosis were reviewed. The radiologic findings, operative findings, and perioperative complications were evaluated. The mean preoperative Cobb angle was 102.816.9 degrees. The curve patterns were a double curve in 2 cases and a triple curve in 2 cases. Local kyphosis at the thoracolumbar area was recognized in all the cases with a mean kyphosis angle of 4916 degrees. Growing rod procedures were performed in 2 patients, and posterior correction and fusion were performed in 2 patients. The mean correction rate was 45% in the patients who underwent the growing rod procedures at the time of growing rod placement and 51% in the patients who underwent posterior correction and fusion. Dislodgement of the proximal anchors occurred in 3 of the 4 patients. One patient developed pseudoarthrosis. Two patients developed deep wound infections, and implant removal was necessary in 1 patient. Surgical treatment for scoliosis in patients with SGS was associated with a high incidence of perioperative and postoperative complications including implant dislodgements and deep wound infections attributable to poor bone quality and a thin body habitus, which are characteristic clinical features of this syndrome. Careful preoperative surgical planning and postoperative care are critical for the surgical treatment of scoliosis associated with SGS, especially in infants requiring multiple surgeries. Level IV.", "neg": "The mammalian target of rapamycin (mTOR) has been suggested as a target for radiosensitization. Given that radiotherapy is a primary treatment modality for glioblastoma (GBM) and that mTOR is often dysregulated in GBM, the goal of this study was to determine the effects of AZD2014, a dual mTORC1/2 inhibitor, on the radiosensitivity of GBM stem-like cells (GSCs). mTORC1 and mTORC2 activities were defined by immunoblot analysis. The effects of this mTOR inhibitor on the in vitro radiosensitivity of GSCs were determined using a clonogenic assay. DNA double strand breaks were evaluated according to H2AX foci. Orthotopic xenografts initiated from GSCs were used to define the in vivo response to AZD2014 and radiation. Exposure of GSCs to AZD2014 resulted in the inhibition of mTORC1 and 2 activities. Based on clonogenic survival analysis, addition of AZD2014 to culture media 1 hour before irradiation enhanced the radiosensitivity of CD133+ and CD15+ GSC cell lines. Whereas AZD2014 treatment had no effect on the initial level of H2AX foci, the dispersal of radiation-induced H2AX foci was significantly delayed. Finally, the combination of AZD2014 and radiation delivered to mice bearing GSC-initiated orthotopic xenografts significantly prolonged survival as compared with the individual treatments. These data indicate that AZD2014 enhances the radiosensitivity of GSCs both in vitro and under orthotopic in vivo conditions and suggest that this effect involves an inhibition of DNA repair. Moreover, these results suggest that this dual mTORC1/2 inhibitor may be a radiosensitizer applicable to GBM therapy.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}550{"query": "Coming off their divisional road win over the Dolphins, the Jets flew to Ralph Wilson Stadium for a Week 4 AFC East duel with the throwback-clad Buffalo Bills. New York scored in the first quarter as running back LaDainian Tomlinson got a 1-yard touchdown run. The Jets added onto their lead in the second quarter with a 19-yard field goal from kicker Nick Folk, followed by quarterback Mark Sanchez completing a 41-yard touchdown pass to wide receiver Braylon Edwards. The Bills closed out the half with quarterback Ryan Fitzpatrick finding tight end David Martin on a 4-yard touchdown pass. New York pulled away in the third quarter as tight end Dustin Keller caught a 3-yard touchdown pass from wide receiver/quarterback Brad Smith, followed by his 2-yard touchdown reception thrown by Sanchez. Afterwards, Tomlinson's 26-yard touchdown run effectively secured the victory. Buffalo closed out the game in the fourth quarter as Fitzpatrick threw a touchdown pass to wide receiver Steve Johnson.", "pos": "Though Chad Pennington was active and in uniform for the Jets, the team erred on the side of caution due to injured right ankle, instead starting second-year backup Kellen Clemens, who was making his first career start. The Ravens' defense welcomed him rudely on his first drive with an interception by Ed Reed. The Ravens were able to attain good field position consistently throughout the first half, and quarterback Kyle Boller (who himself was starting in place of an injured starting quarterback, Steve McNair), capitalized with a two-yard touchdown to Willis McGahee late in the first quarter. The teams traded field goals to start the second quarter; Jets kicker Mike Nugent hit a 50-yard field goal, followed by Matt Stover hitting a 28-yard attempt for the Ravens. After Stover missed a 46-yard try, the Jets tried to respond with Nugent attempting a 52-yard field goal, but Nugent missed wide left, his first miss in twenty attempts dating back to last season. Boller once again took advantage of the short field provided and hit tight end Todd Heap on a four-yard touchdown with six seconds left in the half to extend the Ravens' lead to 17-3. Heap's catch was initially ruled incomplete, but the call was subjected to a booth review and reversed, as replays showed he was able to touch both feet within the end zone. After a quiet third quarter, Stover hit a 43-yard field goal to start the fourth quarter, and extended Baltimore's lead to seventeen. Baltimore's defense, which ranked as the best in the NFL in 2006, was able to shut down Clemens and the Jets for most of the game, but Clemens was able to rally the team in the fourth quarter. Using a no huddle offense, Clemens drove the team down to the Baltimore three-yard line, before the Jets settled for a 21-yard field goal. On the Jets' next possession, 44 and 24-yard strikes by Clemens to Jerricho Cotchery got the Jets to the Ravens' goal line, where he found tight end Chris Baker for a three-yard touchdown, cutting the Jets' deficit to seven. Though the Jets failed to convert the ensuing onside kick, poor clock management by Boller gave the Jets the ball back with 2:38 left in the game. Clemens immediately found Cotchery on a 50-yard catch-and-run, later followed by a 24-yard pass to Laveranues Coles that brought the Jets' to the Baltimore seven-yard line with just over a minute to go. Clemens passed to Justin McCareins for a potential touchdown, but the pass was dropped by McCareins. A second pass to McCareins in the end zone deflected off him and into the arms of Ravens linebacker Ray Lewis for the game-ending interception. The loss made the Jets 8-20 since 2002 in games not started by Chad Pennington.", "neg": "This game is well known for an infamous penalty that occurred during the overtime period. The Jets were lining up for a game winning 56-yard field goal in overtime to try and give them the win. Nick folk kicked the ball, but the kick went wide right and the Patriots appeared to be taking over with a chance to win. However, Chris Jones of New England was called for a controversial unsportsmanlike conduct penalty after pushing his teammate into the offensive line. This penalty would later be named \"leaping\". The penalty gave the Jets another chance and made the field goal attempt a 51-yard attempt. This time, Folk drilled the kick, and the Jets would go on to stun the Patriots. With the win, the Jets improved to 4-3.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}551{"query": "Double homeobox 4 (DUX4) is a candidate disease gene for facioscapulohumeral dystrophy (FSHD), one of the most common muscular dystrophies characterized by progressive skeletal muscle degeneration. Despite great strides in understanding precise genetics of FSHD, the molecular pathophysiology of the disease remains unclear. One of the major limitations has been the availability of appropriate molecular tools to study DUX4 protein. In the present study, we report the development of five new monoclonal antibodies targeted against the N- and C-termini of human DUX4, and characterize their reactivity using Western blot and immunofluorescence staining. Additionally, we show that expression of the canonical full coding DUX4 induces cell death in human primary muscle cells, whereas the expression of a shorter splice form of DUX4 results in no such toxicity. Immunostaining with these new antibodies reveals a differential effect of two DUX4 isoforms on human muscle cells. These antibodies will provide an excellent tool for investigating the role of DUX4 in FSHD pathogenesis.", "pos": "Facioscapulohumeral muscular dystrophy (FSHD), the most prevalent myopathy afflicting both children and adults, is predominantly associated with contractions in the 4q35-localized macrosatellite D4Z4 repeat array. Recent studies have proposed that FSHD pathology is caused by the misexpression of the DUX4 (double homeobox 4) gene resulting in production of a pathogenic protein, DUX4-FL, which has been detected in FSHD, but not in unaffected control myogenic cells and muscle tissue. Here, we report the analysis of DUX4 mRNA and protein expression in a much larger collection of myogenic cells and muscle biopsies derived from biceps and deltoid muscles of FSHD affected subjects and their unaffected first-degree relatives. We confirmed that stable DUX4-fl mRNA and protein were expressed in myogenic cells and muscle tissues derived from FSHD affected subjects, including several genetically diagnosed adult FSHD subjects yet to show clinical manifestations of the disease in the assayed muscles. In addition, we report DUX4-fl mRNA and protein expression in muscle biopsies and myogenic cells from genetically unaffected relatives of the FSHD subjects, although at a significantly lower frequency. These results establish that DUX4-fl expression per se is not sufficient for FSHD muscle pathology and indicate that quantitative modifiers of DUX4-fl expression and/or function and family genetic background are determinants of FSHD muscle disease progression.", "neg": "Facioscapulohumeral dystrophy (FSHD) is characterized by chromatin relaxation of the D4Z4 macrosatellite array on chromosome 4 and expression of the D4Z4-encoded DUX4 gene in skeletal muscle. The more common form, autosomal dominant FSHD1, is caused by contraction of the D4Z4 array, whereas the genetic determinants and inheritance of D4Z4 array contraction-independent FSHD2 are unclear. Here, we show that mutations in SMCHD1 (encoding structural maintenance of chromosomes flexible hinge domain containing 1) on chromosome 18 reduce SMCHD1 protein levels and segregate with genome-wide D4Z4 CpG hypomethylation in human kindreds. FSHD2 occurs in individuals who inherited both the SMCHD1 mutation and a normal-sized D4Z4 array on a chromosome 4 haplotype permissive for DUX4 expression. Reducing SMCHD1 levels in skeletal muscle results in D4Z4 contraction-independent DUX4 expression. Our study identifies SMCHD1 as an epigenetic modifier of the D4Z4 metastable epiallele and as a causal genetic determinant of FSHD2 and possibly other human diseases subject to epigenetic regulation.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}552{"query": "Mars is the fourth planet from the Sun, and the first planet beyond Earths orbit (Figure 1.1). Mars is a quite different from Earth and yet more similar than any other planet. Mars is smaller, colder, drier, and appears to have no life, but volcanoes are common to both planets and Mars has many. Mars is easy to observe, so Mars has been studied more thoroughly than any other extraterrestrial planet. Space probes, rovers, and orbiting satellites have all yielded information to planetary geologists. Although no humans have ever set foot on Mars, both NASA and the European Space Agency have set goals of sending people to Mars sometime between 2030 and 2040. This image of Mars, taken by the Hubble Space Telescope in October, 2005, shows the planets red color, a small ice cap on the south pole, and a dust storm. Viewed from Earth, Mars is reddish in color. The ancient Greeks and Romans named the planet after the god of war. The surface is not red from blood but from large amounts of iron oxide in the soil. The Martian atmosphere is very thin relative to Earths and has much lower atmospheric pressure. Although the atmosphere is made up mostly of carbon dioxide, the planet has only a weak greenhouse effect, so temperatures are only slightly higher than if the planet had no atmosphere. Mars has mountains, canyons, and other features similar to Earth. Some of these surface features are amazing for their size! Olympus Mons is a shield volcano, similar to the volcanoes that make up the Hawaiian Islands. But Olympus Mons is also the largest mountain in the solar system (Figure 1.2). Mars also has the largest canyon in the solar system, Valles Marineris (Figure 1.3). It was previously believed that water cannot stay in liquid form on Mars because the atmospheric pressure is too low. However, there is a lot of water in the form of ice and even prominent ice caps (Figure 1.4). Scientists also think Olympus Mons is about 27 km (16.7 miles/88,580 ft) above the Martian sur- face, more than three times taller than Mount Everest. The volcanos base is about the size of the state of Arizona. Valles Marineris is 4,000 km (2,500 mi) long, as long as Europe is wide, and one-fifth the circumference of Mars. The canyon is 7 km (4.3 mi) deep. By comparison, the Grand Canyon on Earth is only 446 km (277 mi) long and about 2 km (1.2 mi) deep. that there is a lot of ice present just under the Martian surface. This ice can melt when volcanoes erupt, and water can flow across the surface. In late 2015, NASA confirmed the presence of water on Mars. Scientists think that water once flowed over the Martian surface because there are surface features that look like water-eroded canyons. The presence of water on Mars suggests that it might have been possible for life to exist on Mars in the past. Mars has two very small moons that are irregular rocky bodies (Figure 1.5). Phobos and Deimos are named after characters in Greek mythology the two sons of Ares, who followed their father into war. Ares is equivalent to the Roman god Mars. Mars has two small moons, Phobos (left) and Deimos (right). Both were discovered in 1877 and are thought to be captured asteroids. Click image to the left or use the URL below. URL: Click image to the left or use the URL below. URL:", "pos": "Earth formed at the same time as the other planets. The history of Earth is part of the history of the Solar System. Earth came together (accreted) from the cloud of dust and gas known as the solar nebula nearly 4.6 billion years ago, the same time the Sun and the rest of the solar system formed. Gravity caused small bodies of rock and metal orbiting the proto-Sun to smash together to create larger bodies. Over time, the planetoids got larger and larger until they became planets. When Earth first came together it was really hot, hot enough to melt the metal elements that it contained. Earth was so hot for three reasons: Gravitational contraction: As small bodies of rock and metal accreted, the planet grew larger and more massive. Gravity within such an enormous body squeezes the material in its interior so hard that the pressure swells. As Earths internal pressure grew, its temperature also rose. Radioactive decay: Radioactive decay releases heat, and early in the planets history there were many ra- dioactive elements with short half lives. These elements long ago decayed into stable materials, but they were responsible for the release of enormous amounts of heat in the beginning. Bombardment: Ancient impact craters found on the Moon and inner planets indicate that asteroid impacts were common in the early solar system. Earth was struck so much in its first 500 million years that the heat was intense. Very few large objects have struck the planet in the past many hundreds of millions of year. When Earth was entirely molten, gravity drew denser elements to the center and lighter elements rose to the surface. The separation of Earth into layers based on density is known as differentiation. The densest material moved to the center to create the planets dense metallic core. Materials that are intermediate in density became part of the mantle (Figure 1.1). Lighter materials accumulated at the surface of the mantle to become the earliest crust. The first crust was probably basaltic, like the oceanic crust is today. Intense heat from the early core drove rapid and vigorous mantle convection so that crust quickly recycled into the mantle. The recycling of basaltic crust was so effective that no remnants of it are found today. There is not much material to let us know about the earliest days of our planet Earth. What there is comes from three sources: (1) zircon crystals, the oldest materials found on Earth, which show that the age of the earliest crust formed at least 4.4 billion years ago; (2) meteorites that date from the beginning of the solar system, to nearly 4.6 billion years ago (Figure 1.2); and (3) lunar rocks, which represent the early days of the Earth-Moon system as far back as 4.5 billion years ago.", "neg": "The TV science-fiction seriesStar Trekno longer looked far-fetched as four men and four women in black space-suits locked themselves into a giant hi-tech greenhouse, known as a 'biosphere', in the Arizona desert yesterday for a two-year study of the environment. As dawn broke over the Santa Catalina mountains, the eight waved goodbye to television cameras. Edward Ross, their multibillionaire sponsor from a Texas oil family, closed the door of the $150 million structure, with its mini-ocean, marsh, desert, savanna, rain-forest and 3,800 plant and animal species designed to allow the team to recreate Earth and its ecosystems. The so-called Biosphere 2 is the latest of a dozen environmental projects started by the self-titled 'ecopreneur'. The project's main aim is to set up a self-sustaining community for possible use in a spaceship or on another planet. The crew members must plant, harvest and process their food on a half-acre farm in the seven-storey glass and metal structure, while conducting a series of experiments. 'We will be custodians of our new little world,' said Abigail Mayer, aged 31, a US marine biologist on the team, her voice choking with emotion. 'It is a brave new step.' Many scientists, however, are more than skeptical. They point out that the largest closed ecosystem which survived more than a few days was smaller than a football. It was developed at the University of Miami and contained only shrimp, algae and other micro-organisms. Critics have also accused Mr. Ross of being more interested in producing a profitable theme park than in carrying out serious scientific research. Hundreds of tourists visited the site daily in the summer before it was occupied by the team. They paid $9.95 to enter and all stopped at the souvenir shop.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}553{"query": "When you think of life in the ocean, do you think of fish? Actually, fish are not the most common life forms in the ocean. Plankton are the most common. Plankton make up one of three major groups of marine life. The other two groups are nekton and benthos. Figure 14.24 shows the three groups. Plankton are living things that float in the water. Most plankton are too small to see with the unaided eye. Some examples are shown in Figure 14.25. Plankton are unable to move on their own. Ocean motions carry them along. There are two main types of plankton: 1. Phytoplankton are plant-like plankton. They make food by photosynthesis. They live in the photic zone. Most are algae. 2. Zooplankton are animal-like plankton. They feed on phytoplankton. They include tiny animals and fish larvae. Nekton are living things that swim through the water. They may live at any depth, in the photic or aphotic zone. Most nekton are fish, although some are mammals. Fish have fins and streamlined bodies to help them swim. Fish also have gills to take oxygen from the water. Figure 14.26 shows examples of nekton. Benthos are living things on the ocean floor. Many benthic organisms attach themselves to rocks and stay in one place. This protects them from crashing waves and other water movements. Some benthic organisms burrow into sediments for food or protection. Benthic animals may crawl over the ocean floor. Examples of benthos include clams and worms. Figure 14.27 shows two other examples. Some benthos live near vents on the deep ocean floor. Tubeworms are an example (see Figure 14.28). Scalding hot water pours out of the vents. The hot water contains chemicals that some specialized bacteria can use to make food. Tubeworms let the bacteria live inside them. The bacteria get protection and the tubeworms get some of the food. Figure 14.29 shows a marine food chain. Phytoplankton form the base of the food chain. Phytoplankton are the most important primary producers in the ocean. They use sunlight and nutrients to make food by photosynthesis. Small zooplankton consume phytoplankton. Larger organisms eat the small zooplankton. Larger predators eat these consumers. In an unusual relationship, some enormous whales depend on plankton for their food. They filter tremendous amounts of these tiny creatures out of the water. The bacteria that make food from chemicals are also primary producers. These organisms do not do photosynthesis since there is no light at the vents. They do something called chemosynthesis. They break down chemicals to make food. When marine organisms die, decomposers break them down. This returns their nutrients to the water. The nutrients can be used again to make food. Decomposers in the oceans include bacteria and worms. Many live on the ocean floor. Do you know why?", "pos": "When you take a walk along a beach, what do you find there? Sand, the ocean, lots of sunlight. You may also find shells. The shells you find are most likely left by organisms in the phylum Mollusca. On the beach, you can find the shells of many different mollusks ( Figure 1.1), including clams, mussels, scallops, oysters, and snails. Mollusks are invertebrates that usually have a hard shell, a mantle, and a radula. Their glossy pearls, mother of pearl, and abalone shells are like pieces of jewelry. Some mollusks, such as squid and octopus, do not have shells. The Mollusks body is often divided into different parts ( Figure 1.2): On the beach, you can find a wide variety of mollusk shells. 1. A head with eyes or tentacles. 2. In most species, a muscular foot, which helps the mollusk move. Some mollusks use the foot for burrowing into the sand, and others use it for jet-propulsion. 3. A mantle, or fold of the outer skin lining the shell. The mantle often releases calcium carbonate, which creates an external shell, just like the ones you find on the beach. The shell is made of chitin, a tough, semitransparent substance. 4. A mass housing the organs. 5. A complete digestive tract that begins at the mouth and runs to the anus. 6. Most ocean mollusks have a gill or gills to absorb oxygen from the water. 7. Many species have a feeding structure, the radula, found only in mollusks. The radula can be thought of as a \"tongue-like\" structure. The radula is made mostly of chitin. Types of radulae range from structures used to scrape algae off of rocks to the beaks of squid and octopuses. This is the basic body plan of a mollusk. Note the mantle, gills, and radula. Keep in mind the basic body plan can differ slightly among the mollusks. Mollusks are probably most closely related to organisms in the phylum Annelida, also known as segmented worms. This phylum includes the earthworm and leech. Scientists believe these two groups are related because, when they are in the early stage of development, they look very similar. Mollusks also share features of their organ systems with segmented worms. Unlike segmented worms, however, mollusks do not have body segmentation. The basic mollusk body shape is usually quite different as well.", "neg": "Do's and Don'ts in Whale Watching The Department of Fisheries and Oceans has developed guidelines for whale watching in Johnstone Strait,where killer whales are found on a daily basis each summer. It is strongly recommended that vessel operators follow these guidelines for all kinds of whales. * Approach whales from the side, not from the front or the back. * Approach no closer than 100 metres, then stop the boat but keep the engine on. * Keep noise levels down-no horns, whistles or racing of engines. * Start your boat only after the whales are more than 100 metres from your vessel. * Leave the area slowly, gradually moving faster when you are more than 300 metres from the whales. * Approach and leave slowly, avoiding sudden changes in speed or direction. * Avoid disturbing groups of resting whales. * Keep at low speeds and remain in the same direction if travelling side by side with whales. * When whales are travelling close to shore, avoid crowding them near the shore or coming between the whales and the shore. * Limit the time spent with any group of whales to less than 30 minutes at a time when within 100 to 200 metres of whales. * If there is more than one vessel at the same observation spot, be sure to avoid any boat position that would result in surrounding the whales. * Work together by communicating with other vessels, and make sure that all operators are aware of the whale watching guidelines.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}554{"query": "To develop a clinical prediction rule to identify patients who can be safely discharged one hour after the administration of naloxone for presumed opioid overdose. Patients who received naloxone for known or presumed opioid overdose were formally evaluated one hour later for multiple potential predictor variables. Patients were classified into two groups: those with adverse events within 24 hours and those without. Using classification and regression tree methodology, a decision rule was developed to predict safe discharge. Clinical findings from 573 patients allowed us to develop a clinical prediction rule with a sensitivity of 99% (95% CI = 96% to 100%) and a specificity of 40% (95% CI = 36% to 45%). Patients with presumed opioid overdose can be safely discharged one hour after naloxone administration if they: 1) can mobilize as usual; 2) have oxygen saturation on room air of >92%; 3) have a respiratory rate >10 breaths/min and <20 breaths/min; 4) have a temperature of >35.0 degrees C and <37.5 degrees C; 5) have a heart rate >50 beats/min and <100 beats/min; and 6) have a Glasgow Coma Scale score of 15. This prediction rule for safe early discharge of patients with presumed opioid overdose performs well in this derivation set but requires validation followed by confirmation of safe implementation.", "pos": "Opioid overdose is rarely the primary cause of altered mental status in cancer patients receiving opioid therapy. The inappropriate administration of naloxone to reverse an abnormal mental status can cause severe withdrawal symptoms and pain. To illustrate this problem, we report the case of a patient inappropriately treated with naloxone and the results of a retrospective review of the medical records of 15 consecutive patients with cancer treated with naloxone in the emergency department over a 5-month period. We offer guidelines for a more thoughtful approach to the management of patients with cancer who present with encephalopathy.", "neg": "Evaluate efficacy and safety of tanezumab, a humanized monoclonal antibody against nerve growth factor, in neuropathic pain. Two randomized controlled trials. Patients with pain due to diabetic peripheral neuropathy (DPN) or postherpetic neuralgia (PHN). In the DPN study, patients received subcutaneous tanezumab 20 mg or placebo on Day 1 and Week 8. Evaluations included change from baseline in average DPN pain (primary endpoint), Patient's Global Assessment of DPN, and safety (including neuropathy assessments). Due to a partial clinical hold limiting enrollment and treatment duration, the prespecified landmark analysis was modified post hoc from Week 16 to Week 8. In the PHN study, patients received intravenous tanezumab 50 g/kg, tanezumab 200 g/kg, or placebo on Day 1. Evaluations included change from baseline in average daily pain (primary endpoint), Brief Pain Inventory-short form, Patient's Global Assessment of pain from PHN, and safety. Mean DPN pain reduction from baseline to Week 8 was greater with tanezumab vs placebo (P = 0.009); differences in Patient's Global Assessment of DPN were not significant (P > 0.05). Neither tanezumab dose resulted in significant differences vs placebo in efficacy in PHN (P > 0.05), although tanezumab 200 g/kg provided some benefit. Neuropathy assessments showed no meaningful changes. Tanezumab provided effective pain reduction in DPN. In PHN, only the highest tanezumab dose reduced pain; treatment differences were not significant. No new safety concerns were observed despite preexisting neuropathy.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}555{"query": "Teleborg Castle (Teleborgs slott) is beautifully situated near Lake Trummen, 4--5 km south of the city centre of Vaxjo, Sweden.", "pos": "Steninge Palace (also known as Steninge Manor) is a Baroque palace overlooking Lake Malaren near Marsta outside of Stockholm, Sweden.", "neg": "Acanthomintha ilicifolia, known by the common name San Diego thornmint, is a rare species of flowering plant in the mint family.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}556{"query": "Stress is the force applied to an object. In geology, stress is the force per unit area that is placed on a rock. Four types of stresses act on materials. A deeply buried rock is pushed down by the weight of all the material above it. Since the rock cannot move, it cannot deform. This is called confining stress. Compression squeezes rocks together, causing rocks to fold or fracture (break) (Figure 1.1). Compression is the most common stress at convergent plate boundaries. Stress caused these rocks to fracture. Rocks that are pulled apart are under tension. Rocks under tension lengthen or break apart. Tension is the major type of stress at divergent plate boundaries. When forces are parallel but moving in opposite directions, the stress is called shear (Figure 1.2). Shear stress is the most common stress at transform plate boundaries. Shearing in rocks. The white quartz vein has been elongated by shear. When stress causes a material to change shape, it has undergone strain or deformation. Deformed rocks are common in geologically active areas. A rocks response to stress depends on the rock type, the surrounding temperature, the pressure conditions the rock is under, the length of time the rock is under stress, and the type of stress. Rocks have three possible responses to increasing stress (illustrated in Figure 1.3): elastic deformation: the rock returns to its original shape when the stress is removed. plastic deformation: the rock does not return to its original shape when the stress is removed. fracture: the rock breaks. Under what conditions do you think a rock is more likely to fracture? Is it more likely to break deep within Earths crust or at the surface? What if the stress applied is sharp rather than gradual? At the Earths surface, rocks usually break quite quickly, but deeper in the crust, where temperatures and pressures are higher, rocks are more likely to deform plastically. Sudden stress, such as a hit with a hammer, is more likely to make a rock break. Stress applied over time often leads to plastic deformation. Click image to the left or use the URL below. URL:", "pos": "A rock under enough stress will fracture. There may or may not be movement along the fracture. If there is no movement on either side of a fracture, the fracture is called a joint. The rocks below show horizontal and vertical jointing. These joints formed when the confining stress was removed from the rocks as shown in (Figure If the blocks of rock on one or both sides of a fracture move, the fracture is called a fault (Figure 1.2). Stresses along faults cause rocks to break and move suddenly. The energy released is an earthquake. How do you know theres a fault in this rock? Try to line up the same type of rock on either side of the lines that cut across them. One side moved relative to the other side, so you know the lines are a fault. Slip is the distance rocks move along a fault. Slip can be up or down the fault plane. Slip is relative, because there is usually no way to know whether both sides moved or only one. Faults lie at an angle to the horizontal surface of the Earth. That angle is called the faults dip. The dip defines which of two basic types a fault is. If the faults dip is inclined relative to the horizontal, the fault is a dip-slip fault (Figure 1.3). There are two types of dip-slip faults. In a normal fault, the hanging wall drops down relative to the footwall. In a reverse fault, the footwall drops down relative to the hanging wall. This diagram illustrates the two types of dip-slip faults: normal faults and reverse faults. Imagine miners extracting a re- source along a fault. The hanging wall is where miners would have hung their lanterns. The footwall is where they would have walked. A thrust fault is a type of reverse fault in which the fault plane angle is nearly horizontal. Rocks can slip many miles along thrust faults (Figure 1.4). At Chief Mountain in Montana, the upper rocks at the Lewis Overthrust are more than 1 billion years older than the lower rocks. How could this happen? Normal faults can be huge. They are responsible for uplifting mountain ranges in regions experiencing tensional stress. A strike-slip fault is a dip-slip fault in which the dip of the fault plane is vertical. Strike-slip faults result from shear stresses. Imagine placing one foot on either side of a strike-slip fault. One block moves toward you. If that block moves toward your right foot, the fault is a right-lateral strike-slip fault; if that block moves toward your left foot, the fault is a left-lateral strike-slip fault (Figure 1.5). Californias San Andreas Fault is the worlds most famous strike-slip fault. It is a right-lateral strike slip fault (See opening image). People sometimes say that California will fall into the ocean someday, which is not true. Strike-slip faults. Click image to the left or use the URL below. URL:", "neg": "A rock is a naturally formed, non-living Earth material. Rocks are made of collections of mineral grains that are held together in a firm, solid mass (Figure 1.1). How is a rock different from a mineral? Rocks are made of minerals. The mineral grains in a rock may be so tiny that you can only see them with a microscope, or they may be as big as your fingernail or even your finger (Figure Rocks are identified primarily by the minerals they contain and by their texture. Each type of rock has a distinctive set of minerals. A rock may be made of grains of all one mineral type, such as quartzite. Much more commonly, rocks are made of a mixture of different minerals. Texture is a description of the size, shape, and arrangement of mineral grains. Are the two samples in Figure 1.3 the same rock type? Do they have the same minerals? The same texture? The different colors and textures seen in this rock are caused by the presence of different minerals. A pegmatite from South Dakota with crystals of lepidolite, tourmaline, and quartz (1 cm scale on the upper left). Sample 2 Crystals are tiny or microscopic Magma erupted and cooled quickly Andesite As seen in Table 1.1, these two rocks have the same chemical composition and contain mostly the same minerals, but they do not have the same texture. Sample 1 has visible mineral grains, but Sample 2 has very tiny or invisible grains. The two different textures indicate different histories. Sample 1 is a diorite, a rock that cooled slowly from magma (molten rock) underground. Sample 2 is an andesite, a rock that cooled rapidly from a very similar magma that erupted onto Earths surface. A few rocks are not made of minerals because the material they are made of does not fit the definition of a mineral. Coal, for example, is made of organic material, which is not a mineral. Can you think of other rocks that are not made of minerals? Click image to the left or use the URL below. URL: Click image to the left or use the URL below. URL:", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}557{"query": "The Garden of Aunt Isabel (Spanish:El jardin de la tia Isabel) is a 1971 Mexican historical drama film directed by Felipe Cazals and starring Jorge Martinez de Hoyos, Claudio Brook and Ofelia Guilmain.", "pos": "Judge and the Forest (Bulgarian: , translit. Sledovatelyat i gorata) is a 1975 Bulgarian drama film directed by Rangel Vulchanov.", "neg": "Min and Bill is a 1930 American Pre-Code comedy-drama film starring Marie Dressler and Wallace Beery and based on Lorna Moon's novel Dark Star, adapted by Frances Marion and Marion Jackson.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}558{"query": "There were 22,000 households of which 37.1% had children under the age of 18 living with them, 48.3% were Marriage living together, 12.7% had a female householder with no husband present, 5.1% had a male householder with no wife present, and 33.9% were non-families. 26.7% of all households were made up of individuals and 7.5% had someone living alone who was 65 years of age or older. The average household size was 2.70 and the average family size was 3.24.", "pos": "The U.S. Census for 2010 reported 332,199 households in Indianapolis, with an average household size of 2.42 and an average family size of 3.08. Of the total households, 59.3% were family households, with 28.2% of these including the familys own children under the age of 18; 36.5% were husband-wife families; 17.2% had a female householder (with no husband present) and 5.6% had a male householder (with no wife present). The remaining 40.7% were non-family households. , 32% of the non-family households included individuals living alone, 8.3% of these households included individuals age 65 years of age or older.", "neg": "There are 27,908 households, of which 31.5% have children under the age of 18 living with them, 48.9% were married couples living together, 15.4% had a female householder with no husband present, and 32.3% were non-families. 28.4% of all households are made up of individuals, and 10.6% had someone living alone who was 65 years of age or older. The average household size was 2.39, and the average family size was 2.94. 70% of women with school-age children work.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}559{"query": "The film opens in Tokyo, where 27-year-old office worker Taeko Okajima, is planning to take a 10-day vacation. Having previously visited her sister's husband's farm in Yamagata. She had a good time there before, and has decided to go back again.As she prepares for her trip, her mind drifts back to her youth, when she was 10-years-old. After school lets out, almost all of Taeko's classmates have interesting places they are going to go to, but Taeko does not. When she brings this up to her family, they suggest that Taeko go with the family's Grandmother to a hot springs resort.Taeko eagerly goes with her Grandmother, but finds herself bored when all her Grandmother wishes to do is relax in their room. Taeko goes exploring the myriad baths in the resort by herself, but due to either the overwhelming beauty of one bath (or the heat of the baths), she passes out.While packing, she receives a call from her older sister whose husband owns the farm, and they have a laugh over the past incident.On her way to the train to the farm, Taeko passes by a fruit stand, and is reminded of when the family received a pineapple.This also happened during her 10th year, and she recalls how almost noone knew how to properly cut it. Her father decreed that it would not be touched until it was found out, and a few days later, one of Taeko's sister finds out. There is much eagerness once it is sliced into pieces, but slowly, the family quickly discerns they do not like its taste. Taeko attempts to stomach the pieces she has, and her sisters give her their pieces. In the end, the family concluded that the banana is the \"king of fruits.\"Making it to the train station, Taeko also recalls more about the year 1966, when she was 10-years-old. With the popularity of the Beatles in full-swing, her sisters became enamored with the trends of the time. Her sister Nanako was in art school, and kept up with trends, including wearing a mini-skirt. Her other sister Yaeko had a small crush on an actress in a female acting troupe. However, while her sisters remember these things fondly, Taeko recalls she was too young to really get into these trends like her older sisters.One day after showing her Mother her grades, her Mother finds leftovers from her lunch, and expresses her disappointment in her daughter being picky, and not finishing her food. The next day at lunch, she is sitting next to a boy who is fine with finishing the radish and onion portion of his meal, but dislikes finishing his milk (per school rules, a student can only leave one item to be thrown away from their meal). Taeko offers to give him her radish and onions, and she'll finish his milk. The two quickly make a trade, but Taeko quickly finds that though she has no problems drinking milk, there's a bit too much for her to enjoy a second bowl.Afterwards, Taeko and several of her friends take part in a classroom debate. The topics cover everything from running in the halls, to handling leftovers. Not much is done regarding the issues, and there is much bickering and yelling.After remembering these things, the adult Taeko boards her train for the farm.Once aboard, her memories shift back to an encounter, where three girls from another class gigglingly inform her that a boy in their class named Hirota likes her. Taeko has no idea who Hirota, and her friends show her some graffiti near the school, showing Taeko and Hirota's name under an umbrella-like drawing. Her friends do some research, and find out that Hirota is a good pitcher for his classroom's baseball team.One day, both Taeko and Hirota's classes are pitted against each other in a baseball game.Hirota's female classmates eagerly chant that Taeko is watching, and Taeko's friends cheer for their own homeroom team, in defiance of the other girls. During the game, the cold gets to Takeko, and she rushes for the", "pos": "Ten-year-old Chihiro (voice: Daveigh Chase in the 2002 English dub) and her parents (voices: Lauren Holly and Michael Chiklis) drive to their new home. Chihiro is whiny and unhappy about the move, especially when she notices that the bouquet her friend gave her as a good-bye gift is wilting. In sight of their new house, they take a wrong turn and follow a bumpy, decayed old road through the woods; Chihiro sees an odd old statue through the trees as they drive by. The road ends at a tunnel leading to an abandoned theme park. It gives Chihiro the creeps, but her parents persuade her to go in with them and look around.After wandering across a grassy landscape and a dry riverbed, they climb a stone staircase and come to a street lined with restaurants and shops. Most are deserted, but the aroma of cooking leads them to the one restaurant that's well stocked with food -- though it's mysteriously deserted. Mom and Dad are hungry and start eating, despite Chihiro's objections. The food is delicious, and Chihiro wanders away to explore while they eat. She finds a towering, ornate building that she recognizes as a bathhouse (a spa resort); there's a train track running under it. She meets a boy (voice: Jason Marsden) in traditional dress who is alarmed to see her; he tells her to leave and get back across the river before it gets dark. Chihiro runs back to her parents, but they're still eating -- and they've turned into pigs. Strange, dark, ghostly figures appear in all the shops and streets, frightening Chihiro and separating her from the pigs that were her parents. Chihiro runs back to the river, which was nearly dry when they came over but is now full and large, and she doesn't even recognize the buildings on the far side. As a riverboat approaches, she notices that her body has become transparent.The riverboat lands a big crowd of people in costume -- or maybe they're not people; at first they're only visible as paper masks. Chihiro thinks shes dreaming, but can't wake up. The boy who warned her away finds her and tells her she must eat some food from his world or she'll fade away. He assures her that she won't turn into a pig. She swallows the morsel he gives her and becomes solid, but finds that she's stuck to the ground until he recites an incantation to release her. A bird with a woman's head flies above them and he hides her, saying the bird is looking for her. They run through alleys and the pig barn to the big bathhouse, which is accessed by a bridge; the boy says she has to hold her breath as they cross the bridge or the spell that makes her invisible will be broken. Customers -- fantastically varied gods and spirits -- are crossing the bridge and being greeted by bathhouse staff. Chihiro makes it almost all the way across, but a frog (voice: Bob Bergen) that speaks to her companion (calling him Haku) startles her and she takes a breath. Luckily only the frog seems to see her, and Haku uses magic to encase it in a bubble to shut it up.Haku tells her to find Kamajii (voice: David Ogden Stiers), the boiler man, and make him give her a job; she must have a job to stay at the bathhouse, or else Yubaba (voice: Suzanne Pleshette), the old witch who rules the bathhouse, will turn her into an animal. And Haku says she has to stay if she wants to find and help her parents, who are still pigs, wherever they are. He knows her name and says he's known her since she was very small.Chihiro descends a steep, winding, rail-less wooden stairway in search of Kamajii and the boiler room. When she finds them, she sees a weird set-up in which the boiler is fed by creatures like spiders (delivering coal one lump at a time) and the machinery is controlled by a bearded, bald man", "neg": "Chettinad Palace in Karaikudi seen in the film. Natesan (Cheran) works as an engineer in electricity board in Karaikudi and leads a joint family with more 30 of his relatives living in the same house. On the other hand, Visalakshi aka Sala (Sneha) is the only daughter to her parents and she is about to complete her college education in Karaikudi. Sala feels bored while being alone and she always prefers to have her friends surrounding her. Sala's parents start searching for a groom and they get a reference for Natesan. Sala and her family meet Natesan's family in a function. Sala is surprised to see so many people living as a joint family together and she is very much impressed and agrees for the wedding. Natesan and Sala get married. Sala loves being accompanied by all the relatives in Natesan's home. When Sala and Natesan go on a honeymoon, Sala purchases gifts for everyone in the family. All the family members are also impressed seeing Sala. But Natesan feels sad that he does not get private time to spend with his wife as they are always surrounded by relatives. Now Natesan gets transferred to a hill station named Attakatti, near Pollachi. Natesan feels happy as he believes this will provide him time to spend with Sala. Although Sala feels sad leaving all her relatives, she also goes with Natesan to the hill station. Over there in the hill station, Sala feels lonely and gets bored and she longs for the life she had in Karaikudi. Their house is located in a remote place with no neighbours and friends. Natesan also gets busy with work and has very little time to spend with his wife. Slowly Sala gets psychologically disturbed due to loneliness and she behaves as if the house is filled with so many people. Also, she repairs the fan, lights etc. purposefully in their home so that the nearby electrician (Kanja Karuppu) comes to fix them and at least she gets a chance to speak to someone. She also starts recording all the sounds around her such as birds chirping, etc. and listens to the recordings when alone. One day, she records a neighbour's child's laughter sound following which the child faints. Sala is scared but the child is saved. Doctor Ramalingam (Jayaram) sees Sala and understands that she is suffering from a disorder and warns Natesan. But Natesan does not take it seriously. One day Sala consumes too much of sleeping pills to come out of her depression. But Natesan spots her lying in bed and rushes her to the hospital. Sala is saved. Ramalingam explains the disorder to Natesan and mentions that the best cure for her would be to lead a happy life surrounded by relatives. Natesan agrees and moves back to Karaikudi. The movie ends showing Natesan and Sala leading a happy life again.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}560{"query": "The TMEM18 protein's amino acid sequence is well conserved, which suggests that it has retained its function since the divergence of human and plants.", "pos": "FK506 binding protein 6, also known as FKBP6, is a human gene.", "neg": "In plant, primary transcripts (pri-miRNAs) transcribed from miRNA genes by RNA polymerase II are first processed into stem-loop pre-miRNAs and further chopped into 21nt long miRNAs by RNase III-like enzyme DCL1. SERRATE (SE) protein is an essential component for miRNA processing by assisting DCL1 for accurate cleavage. Here we report the crystal structure of Arabidopsis SE core (residues 194-543) at 2.7A. SE core adopts the 'walking man-like' topology with N-terminal helices, C-terminal non-canonical zinc-finger domain and novel Middle domain resembling the leading leg, the lagging leg and the body, respectively. Pull-down assay shows that SE core provides the platform for HYL1 and DCL1 binding, whereas in vitro RNA binding and in vivo mutant rescue experiments suggest that the non-canonical zinc-finger domain coupled with C-terminal tail binds miRNA precursors. SE presumably works as a scaffold-like protein capable of binding both protein and RNA to guide the positioning of miRNA precursor toward DCL1 catalytic site within miRNA processing machinery in plant.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}561{"query": "The Battle of Coutras, fought on 20 October 1587, was a major engagement in the French Religious Wars between a Huguenot (Protestant) army under Henry of Navarre (the future Henry IV of France) and a royalist army led by Anne, Duke of Joyeuse.", "pos": "The Battle of Munchengratz (German: Schlacht bei Munchengratz) or Battle of Mnichovo Hradiste (Czech: Bitva u Mnichova Hradiste) was fought near Mnichovo Hradiste, modern day Czech Republic, on 28 June 1866 during the Austro-Prussian War.", "neg": "Agnes of Jesus, O.P., (born Agnes Galand and also known as Agnes of Langeac; November 17, 1602 -- October 19, 1634) was a French Catholic nun of the Dominican Order.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}562{"query": "Abi Curtis received a PhD in Creative and Critical Writing from the University of Sussex, and went on to teach there until 2010.", "pos": "Alison Gopnik (born June 16, 1955) is an American professor of psychology and affiliate professor of philosophy at the University of California, Berkeley.", "neg": "While most teachers enjoy the summer break from work, other teachers try to find part-time work during that time. If you're one of those teachers who are finding part-time work during the summer, writing for children might be the right job you're looking for. During the school year, you're very familiar with children in your classroom. That means you know what children think about, how they talk and how they act. If you read stories and books for children with your students during the school year, you also know the kinds of story that children are fond of. As a teacher, you can go to the school library and find out what kinds of books students are most interested in. Also, what kinds of books seem to be in short supply? Use this information to create stories and novels. If you continue writing for children during the school year, you won't have enough time to write as much while you're teaching, but you can probably manage to work on at least one short story for children each month. Even if you don't finish these pieces during the school year, when school ends for the summer you will have lots of writing projects to finish and hand in to editors . Recently, many teachers have turned to writing for children as a part-time job. If you enjoy writing as much as you enjoy teaching, then writing for children might be the second job for you, too.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}563{"query": "Air quality is a measure of the pollutants in the air. More pollutants mean poorer air quality. Air quality, in turn, depends on many factors. Some natural processes add pollutants to the air. For example, forest fires and volcanoes add carbon dioxide and soot. In dry areas, the air often contains dust. However, human actions cause the most air pollution. The single biggest cause is fossil fuel burning. Poor air quality started to become a serious problem after the Industrial Revolution. The machines in factories burned coal. This released a lot of pollutants into the air. After 1900, motor vehicles became common. Cars and trucks burn gasoline, which adds greatly to air pollution. By the mid-1900s, air quality in many big cities was very bad. The worst incident came in December 1952. A temperature inversion over London, England, kept cold air and pollutants near the ground. The air became so polluted that thousands of people died in just a few days. This event was called the Big Smoke. At the same time, many U.S. cities had air pollution problems. Some of the worst were in California. Cars were becoming more popular. Oil refineries and power plants also polluted the air. Mountain ranges trapped polluted air over cities. The California sunshine caused chemical reactions among the pollutants. These reactions produced many more harmful compounds. By 1970, it was clear that something needed to be done to protect air quality. In the U.S., the Clean Air Act was passed. It limits what can be released into the air. As a result, the air in the U.S. is much cleaner now than it was 50 years ago. But air pollution has not gone away. Vehicles, factories, and power plants still release more than 150 million tons of pollutants into the air each year. There are two basic types of pollutants in air. They are known as primary pollutants and secondary pollutants. Primary pollutants enter the air directly. Some are released by natural processes, like ash from volcanoes. Most are released by human activities. They pour into the air from vehicles and smokestacks. Several of these pollutants are described below. Carbon oxides include carbon monoxide (CO) and carbon dioxide (CO2 ). Carbon oxides are released when fossil fuels burn. Nitrogen oxides include nitric oxide (NO) and nitrogen dioxide (NO2 ). Nitrogen oxides form when nitrogen and oxygen combine at high temperatures. This occurs in hot exhausts from vehicles, factories, and power plants. Sulfur oxides include sulfur dioxide (SO2 ) and sulfur trioxide (SO3 ). Sulfur oxides are produced when sulfur and oxygen combine. This happens when coal burns. Coal can contain up to 10 percent sulfur. Toxic heavy metals include mercury and lead. Mercury is used in some industrial processes. It is also found in fluorescent light bulbs. Lead was once widely used in gasoline, paint, and pipes. It is still found in some products. Volatile organic compounds (VOCs) are carbon compounds such as methane. VOCs are released in many human activities, such as raising livestock. Livestock wastes produce a lot of methane. Particulates are solid particles. These particles may be ash, dust, or even animal wastes. Many are released when fossil fuels burn (see Figure 22.1). Secondary pollutants form when primary pollutants undergo chemical reactions after they are released. Many occur as part of photochemical smog. This type of smog is seen as a brown haze in the air. Photochemical smog forms when certain pollutants react together in the presence of sunlight. You can see smog hanging in the air over San Francisco in Figure 22.2. Photochemical smog consists mainly of ozone (O3 ). The ozone in smog is the same compound as the ozone in the ozone layer,(O3 ). But ozone in smog is found near the ground. Figure 22.3 shows how it forms. When nitrogen oxides and VOCs are heated by the Sun, they lose oxygen atoms. The oxygen atoms combine with molecules of oxygen to form ozone. Smog ozone is harmful to humans and other living things. Most pollutants enter the air when fossil fuels burn. Some are released when forests burn.", "pos": "Human health suffers in locations with high levels of air pollution. Different pollutants have different health effects: Lead is the most common toxic material and is responsible for lead poisoning. Carbon monoxide can kill people in poorly ventilated spaces, such as tunnels. Nitrogen and sulfur-oxides cause lung disease and increased rates of asthma, emphysema, and viral infections such as the flu. Ozone damages the human respiratory system, causing lung disease. High ozone levels are also associated with increased heart disease and cancer. Particulates enter the lungs and cause heart or lung disease. When particulate levels are high, asthma attacks are more common. By some estimates, 30,000 deaths a year in the United States are caused by fine particle pollution. Many but not all cases of asthma can be linked to air pollution. During the 1996 Olympic Games, Atlanta, Georgia, closed off their downtown to private vehicles. This action decreased ozone levels by 28%. At the same time, there were 40% fewer hospital visits for asthma. Can scientists conclude without a shadow of a doubt that the reduction in ozone caused the reduction in hospital visits? What could they do to make that determination? Lung cancer among people who have never smoked is around 15% and is increasing. One study showed that the risk of being afflicted with lung cancer increases directly with a persons exposure to air pollution (Figure 1.1). The study concluded that no level of air pollution should be considered safe. Exposure to smog also increased the risk of dying from any cause, including heart disease. One study found that in the United States, children develop asthma at more than twice the rate of two decades ago and at four times the rate of children in Canada. Adults also suffer from air pollution-related illnesses that include lung disease, heart disease, lung cancer, and weakened immune systems. The asthma rate worldwide is rising 20% to 50% every decade.", "neg": "The Clean Air Act of 1970 and the amendments since then have done a great job in requiring people to clean up the air over the United States. Emissions of the six major pollutants regulated by the Clean Air Act carbon monoxide, lead, nitrous oxides, ozone, sulfur dioxide, and particulates have decreased by more than 50%. Cars, power plants, and factories individually release less pollution than they did in the mid-20th century. But there are many more cars, power plants, and factories. Many pollutants are still being released and some substances have been found to be pollutants that were not known to be pollutants in the past. There is still much work to be done to continue to clean up the air. Reducing air pollution from vehicles can be done in a number of ways. Breaking down pollutants before they are released into the atmosphere. Motor vehicles emit less pollution than they once did because of catalytic converters (Figure 1.1). Catalytic converters contain a catalyst that speeds up chemical reactions and breaks down nitrous oxides, carbon monoxide, and VOCs. Catalytic converters only work when they are hot, so a lot of exhaust escapes as the car is warming up. Catalytic converters are placed on mod- ern cars in the United States. Making a vehicle more fuel efficient. Lighter, more streamlined vehicles need less energy. Hybrid vehicles have an electric motor and a rechargeable battery. The energy that would be lost during braking is funneled into charging the battery, which then can power the car. The internal combustion engine only takes over when power in the battery has run out. Hybrids can reduce auto emissions by 90% or more, but many models do not maximize the possible fuel efficiency of the vehicle. A plug-in hybrid is plugged into an electricity source when it is not in use, perhaps in a garage, to make sure that the battery is charged. Plug-in hybrids run for a longer time on electricity and so are less polluting than regular hybrids. Plug-in hybrids began to become available in 2010. Developing new technologies that do not use fossil fuels. Fueling a car with something other than a liquid organic-based fuel is difficult. A fuel cell converts chemical energy into electrical energy. Hydrogen fuel cells harness the energy released when hydrogen and oxygen come together to create water (Figure 1.2). Fuel cells are extremely efficient and they produce no pollutants. But developing fuel-cell technology has had many problems and no one knows when or if they will become practical. Pollutants are removed from the exhaust streams of power plants and industrial plants before they enter the atmo- sphere. Particulates can be filtered out, and sulfur and nitric oxides can be broken down by catalysts. Removing these oxides reduces the pollutants that cause acid rain. Particles are relatively easy to remove from emissions by using motion or electricity to separate particles from the gases. Scrubbers remove particles and waste gases from exhaust using liquids or neutralizing materials (Figure 1.3). Gases, such as nitrogen oxides, can be broken down at very high temperatures. A hydrogen fuel-cell car looks like a gasoline-powered car. Scrubbers remove particles and waste gases from exhaust. Gasification is a developing technology. In gasification, coal (rarely is another organic material used) is heated to extremely high temperatures to create syngas, which is then filtered. The energy goes on to drive a generator. Syngas releases about 80% less pollution than regular coal plants, and greenhouse gases are also lower. Clean coal plants do not need scrubbers or other pollution control devices. Although the technology is ready, clean coal plants are more expensive to construct and operate. Also, heating the coal to high enough temperatures uses a great deal of energy, so the technology is not energy efficient. In addition, large amounts of the greenhouse gas CO2 are still released with clean coal technology. Nonetheless, a few of these plants are operating in the United States and around the world. How can air pollution be reduced? Using less fossil fuel is one way to lessen pollution. Some examples of ways to conserve fossil fuels are: Riding a bike or walking instead of driving", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}564{"query": "Jonas Valanciunas (Lithuanian pronunciation: (jons vntuns); born 6 May 1992) is a Lithuanian professional basketball player for the Toronto Raptors of the National Basketball Association (NBA).", "pos": "Vukadin Vukadinovic (born 14 December 1990) is a professional Serbian football midfielder currently playing for FC Fastav Zlin on loan from FK Baumit Jablonec.", "neg": "The Life Before This is a 1999 Canadian film directed by Jerry Ciccoritti.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}565{"query": "Sergey Kalyakin (Belarusian: ; b. June 16, 1952 in Minsk) is a politician, leader of the Belarusian Left Party ''A Just World'' (till 2009 - the Party of Communists of Belarus).", "pos": "Reza Rezaee (Persian: ; born December 24, 1960) is a Norwegian-Iranian politician representing the left-wing political party Red.", "neg": "Ellen Horn (born Stoesen, 1 February 1951 in Montreal, Canada) is a Norwegian actress, theater director, and politician for the Labour Party.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}566{"query": "''The Lighthouse's Tale'' is a song by progressive bluegrass band Nickel Creek, taken from their debut album, Nickel Creek, released in 2001.", "pos": "Restless in the Tides is the first full-length album by heavy metal music group Forever in Terror.", "neg": "Ass Ponys was an indie rock band based in Cincinnati, Ohio.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}567{"query": "Heavily in debt, Clinton lobbied the Duke of Newcastle for profitable employment as an American governor: he was appointed Governor of the Province of New York in July 1741 and arrived in New York in September 1743 to take up his position. Promoted to rear-admiral on 10 December 1743 and vice-admiral on 23 June 1744, he sought to protect New York's Northern border from attack by the French: however liberal members of the New York assembly resisted his proposals as they wanted to maintain trade links with the French and with the Native Americans who were under French influence. James De Lancey, who had initially been his main adviser, turned against him and sought to block the governor's salary. Clinton therefore invited Sir William Johnson to take over responsibility for Native American affairs in 1746 and appointed Cadwallader Colden to be his advisor. Clinton was promoted to full admiral on 15 July 1747. Working with the Mohawk chief Hendrick Theyanoguin, Johnson was able to recruit Mohawk warriors to fight on the side of the British in 1747 during King George's War. After continuing disputes with the assembly over military expenditure and payment of the governor's salary, Clinton resigned as governor in October 1753.", "pos": "The War of the Spanish Succession ended with the Treaty of Utrecht in 1713. The colonial borders of northeastern North America were reshaped as a result, but the treaty did not account for Indian claims to the same area. French Acadia was ceded to Great Britain which established the province of Nova Scotia, although its borders were disputed. The area disputed by the European powers consisted of land between the Kennebec River and the Isthmus of Chignecto . This land was occupied by a number of Algonquian-speaking Indian tribes loosely allied in the Wabanaki Confederacy, which also claimed sovereignty over most of this territory and had occupancy preceding that of the Colonists. Massachusetts Governor Joseph Dudley organized a major peace conference at Portsmouth, New Hampshire. In negotiations there and at Casco Bay, the Wabanaki present orally objected to British assertions that the French had ceded their territory to Britain in eastern Maine and New Brunswick, and agreed to a confirmation of boundaries at the Kennebec River and the establishment of government-run trading posts in their territory.:162-163 The Treaty of Portsmouth was ratified on July 13, 1713 by eight representatives of the Wabanaki Confederacy, however, which asserted British sovereignty over their territory.:107-110 Over the next year, other Abenaki tribal leaders also signed the treaty, but no Mi'kmaq ever signed it or any other treaty until 1726.:97-98", "neg": "The Jets' seventh game was an interconference duel with the Packers. Punter Steve Weatherford made the game's most controversial decision in the first quarter, opting to attempt a fake punt and run for the first down on 4th and 18. Weatherford was stopped a yard short of the first down, giving the Packers ideal field position which eventually led to an early 3-0 Packers lead. \"He does it on his own,\" Ryan said. \"(The Packers) were caving that side down. This was something Steve did on his own. I don't think he realized we'd just been sacked. We told him before that it needed to be a manageable situation, not fourth-and-20 or whatever it was.\". In a game where defense ruled, the Packers lead 3-0 at halftime. The Jets challenged a Brad Smith fumble, and lost due to his knee not being down before losing the ball. However, the Jets second challenge went to a jump ball, called an interception after Packers cornerback Tramon Williams ripped the ball out of Jerricho Cotchery's hands while they were both on the ground. The play was controversially upheld, despite the fact that the receiver appeared to be down by contact. With no challenges left, Mark Sanchez threw a ball to Dustin Keller that was ripped out of his hands and ruled an interception in the 4th quarter. The replay showed that Keller made the catch and was also down before losing possession, but with no challenges left the Jets were left with nothing. Green Bay took a 6-0 lead after the turnover. The Jets had two more chances to take the lead but had drives halted on 4th and longs. The Packers added on another field goal late to finalize a 9-0 win in the New Meadowlands Stadium. This marked the first time since 2006 the Jets were shut out.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}568{"query": "Trash from land may end up as trash in the ocean, sometimes extremely far from land. Some of it will eventually wash ashore, possibly far from where it originated (Figure 1.1). Although people had once thought that the trash found everywhere at sea was from ships, it turns out that 80% is from land. Some of that is from runoff, some is blown from nearshore landfills, and some is dumped directly into the sea. The 20% that comes from ships at sea includes trash thrown overboard by large cruise ships and many other vessels. It also includes lines and nets from fishing vessels. Ghost nets, nets abandoned by fishermen intentionally or not, float the seas and entangle animals so that they cannot escape. Containers sometimes go overboard in storms. Some noteworthy events, like a container of rubber ducks that entered the sea in 1992, are used to better understand ocean currents. The ducks went everywhere! About 80% of the trash that ends up in the oceans is plastic. This is because a large amount of the trash produced since World War II is plastic. Also many types of plastic do not biodegrade, so they simply accumulate. While many types of plastic photodegrade that is, they break up in sunlight this process only works when the plastics are dry. Plastic trash in the water does break down into smaller pieces, eventually becoming molecule-sized polymers. Other trash in the oceans includes chemical sludge and materials that do biodegrade, like wood. Some plastics contain toxic chemicals, such as bisphenol A. Plastics can also absorb organic pollutants that may be floating in the water, such as the pesticide DDT (which is banned in the U.S. but not in other nations) and some endocrine disruptors. Trash from the lands all around the North Pacific is caught up in currents. The currents bring the trash into the center of the North Pacific Gyre. Scientists estimate that it takes about six years for trash to move from west coast of North America to the center of the gyre. The concentration of trash increases toward the center of the gyre. While recognizable pieces of garbage are visible, much of the trash is tiny plastic polymers that are invisible but can be detected in water samples. The particles are at or just below the surface within the gyre. Plastic confetti-like pieces are visible beneath the surface at the gyres center. This albatross likely died from the plastic it had ingested. The size of the garbage patch is unknown, since it cant be seen from above. Some people estimate that its twice the size of continental U.S, with a mass of 100 million tons. Marine birds, such as albatross, or animals like sea turtles, live most of their lives at sea and just come ashore to mate. These organisms cant break down the plastic and they may eventually die (Figure 1.2). Boats may be affected. Plastic waste is estimated to kill 100,000 sea turtles and marine mammals annually, but exact numbers are unknown. Plastic shopping bags are extremely abundant in the oceans. If an organism accidentally ingests one, it may clog digestion and cause starvation by stopping food from moving through or making the animal not feel hungry. In some areas, plastics have seven times the concentration of zooplankton. This means that filter feeders are ingesting a lot of plastics. This may kill the organisms or the plastics may remain in their bodies. They are then eaten by larger organisms that store the plastics and may eventually die. Fish may eat organisms that have eaten plastic and then be eaten by people. This also exposes humans to toxic chemicals that the fish may have ingested with the plastic. There are similar patches of trash in the gyres of the North Atlantic and Indian oceans. The Southern Hemisphere has less trash buildup because less of the region is continent.", "pos": "Water pollution contributes to water shortages by making some water sources unavailable for use. In underdeveloped countries, raw sewage is dumped into the same water that people drink and bathe in. Even in developed countries, water pollution affects human and environmental health. Water pollution includes any contaminant that gets into lakes, streams, and oceans. The most widespread source of water contamination in developing countries is raw sewage. In developed countries, the three main sources of water pollution are described below. Wastewater from cities and towns contains many different contaminants from many different homes, businesses, and industries (Figure 1.1). Contaminants come from: Sewage disposal (some sewage is inadequately treated or untreated). Storm drains. Septic tanks (sewage from homes). Boats that dump sewage. Yard runoff (fertilizer and herbicide waste). Large numbers of sewage spills into San Francisco Bay are forcing cities, water agencies and the public to take a closer look at wastewater and its impacts on the health of the bay. QUEST investigates the causes of the spills and whats being done to prevent them. Click image to the left or use the URL below. URL: Factories and hospitals spew pollutants into the air and waterways (Figure 1.2). Some of the most hazardous industrial pollutants include: Radioactive substances from nuclear power plants and medical and scientific sources. Heavy metals, organic toxins, oils, and solids in industrial waste. Chemicals, such as sulfur, from burning fossil fuels. Oil and other petroleum products from supertanker spills and offshore drilling accidents. Heated water from industrial processes, such as power stations. Runoff from crops, livestock, and poultry farming carries contaminants such as fertilizers, pesticides, and animal waste into nearby waterways (Figure 1.3). Soil and silt also run off farms. Animal wastes may carry harmful diseases, particularly in the developing world. The high density of animals in a factory farm means that runoff from the area is full of pollutants. Fertilizers that run off of lawns and farm fields are extremely harmful to the environment. Nutrients, such as nitrates, in the fertilizer promote algae growth in the water they flow into. With the excess nutrients, lakes, rivers, and bays become clogged with algae and aquatic plants. Eventually these organisms die and decompose. Decomposition uses up all the dissolved oxygen in the water. Without oxygen, large numbers of plants, fish, and bottom-dwelling animals die.", "neg": "When you take a walk along a beach, what do you find there? Sand, the ocean, lots of sunlight. You may also find shells. The shells you find are most likely left by organisms in the phylum Mollusca. On the beach, you can find the shells of many different mollusks ( Figure 1.1), including clams, mussels, scallops, oysters, and snails. Mollusks are invertebrates that usually have a hard shell, a mantle, and a radula. Their glossy pearls, mother of pearl, and abalone shells are like pieces of jewelry. Some mollusks, such as squid and octopus, do not have shells. The Mollusks body is often divided into different parts ( Figure 1.2): On the beach, you can find a wide variety of mollusk shells. 1. A head with eyes or tentacles. 2. In most species, a muscular foot, which helps the mollusk move. Some mollusks use the foot for burrowing into the sand, and others use it for jet-propulsion. 3. A mantle, or fold of the outer skin lining the shell. The mantle often releases calcium carbonate, which creates an external shell, just like the ones you find on the beach. The shell is made of chitin, a tough, semitransparent substance. 4. A mass housing the organs. 5. A complete digestive tract that begins at the mouth and runs to the anus. 6. Most ocean mollusks have a gill or gills to absorb oxygen from the water. 7. Many species have a feeding structure, the radula, found only in mollusks. The radula can be thought of as a \"tongue-like\" structure. The radula is made mostly of chitin. Types of radulae range from structures used to scrape algae off of rocks to the beaks of squid and octopuses. This is the basic body plan of a mollusk. Note the mantle, gills, and radula. Keep in mind the basic body plan can differ slightly among the mollusks. Mollusks are probably most closely related to organisms in the phylum Annelida, also known as segmented worms. This phylum includes the earthworm and leech. Scientists believe these two groups are related because, when they are in the early stage of development, they look very similar. Mollusks also share features of their organ systems with segmented worms. Unlike segmented worms, however, mollusks do not have body segmentation. The basic mollusk body shape is usually quite different as well.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}569{"query": "Jean-Francois Domergue (born 23 June 1957) is a former French footballer who played defender.", "pos": "Miguel Angel Garcia Tebar (born 26 September 1979), known as Miguel Garcia, is a Spanish retired footballer who played as a defensive midfielder.", "neg": "Boris Babacar Diaw-Riffiod, better known as Boris Diaw (born April 16, 1982), is a French professional basketball player for the San Antonio Spurs of the National Basketball Association (NBA).", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}570{"query": "Conus velaensis is a species of sea snail, a marine gastropod mollusk in the family Conidae, the cone snails and their allies.", "pos": "Clathrodrillia walteri is a species of sea snail, a marine gastropod mollusk in the family Drilliidae.", "neg": "Have you ever been to the ocean or eaten seafood? If you have, then youve probably encountered members of Phylum Mollusca. In addition to snails, mollusks include squids, slugs, scallops, and clams. You can see a clam in Figure 12.15. There are more than 100,000 known species of mollusks. Some mollusks are nearly microscopic. The largest mollusk, the colossal squid, may be as long as a school bus and weigh over half a ton! Watch this short video to see an amazing diversity of mollusks: . MEDIA Click image to the left or use the URL below. URL: Mollusks have a true coelom and complete digestive system. They also have circulatory and excretory systems. They have a heart that pumps blood, and organs that filter out wastes from the blood. You can see some other traits of mollusks in the garden snail in Figure 12.16. Like the snail, many other mollusks have a hard outer shell. It is secreted by special tissue called mantle on the outer surface of the body. The shell covers the top of the body and encloses the internal organs. Most mollusks have a distinct head region. The head may have tentacles for sensing the environment and grasping food. Mollusks generally have a muscular foot, which may be used for walking or other purposes. A unique feature of mollusks is the radula. This is a feeding organ with teeth made of chitin. It is located in front of the mouth in the head region. It can be used to scrape algae off rocks or drill holes in the shells of prey. You can see the radula of the sea slug in Figure 12.17. Mollusks reproduce sexually. Most species have separate male and female sexes. Fertilization may be internal or external, depending on the species. Fertilized eggs develop into larvae. There may be one or more larval stages. Each one is different from the adult stage. Mollusks live in most terrestrial, freshwater, and marine habitats. However, the majority of species live in the ocean. They can be found in both shallow and deep water and from tropical to polar latitudes. They have a variety of ways of getting food. Some are free-living heterotrophs. Others are internal parasites. Mollusks are also eaten by many other organisms, including humans. Annelids are segmented worms in Phylum Annelida. There are about 15,000 species of annelids. They range in length from less than a millimeter to more than 3 meters. To learn more about the amazing diversity and adaptations of annelids, watch this excellent video: [Link] MEDIA Click image to the left or use the URL below. URL: Annelids are divided into many repeating segments. The earthworm in Figure 12.18 is an annelid. You can clearly see its many segments. Segmentation of annelids is highly adaptive. Each segment has its own nerve and muscle tissues. This allows the animal to move very efficiently. Some segments can also be specialized to carry out particular functions. They may have special structures on them. For example, they might have tentacles for sensing or feeding, paddles for swimming, or suckers for clinging to surfaces. Annelids have a large coelom. They also have several organ systems. These include a: circulatory system; excretory system; complete digestive system; and nervous system, with a brain and sensory organs. Most annelids can reproduce both asexually and sexually. Asexual reproduction may occur by budding or fission. Sexual reproduction varies by species. Some species go through a larval stage before developing into adults. Other species grow to adult size without going through a larval stage. Annelids live in a diversity of freshwater, salt-water, and terrestrial habitats. They vary in what they eat and how they get their food. Some annelids, such as earthworms, eat soil and extract organic material from it. Annelids called leeches are either predators or parasites. Some leeches capture and eat other invertebrates. Others feed off the blood of vertebrate hosts. Annelids called polychaete worms live on the ocean floor. They may be filter feeders, predators, or scavengers. The amazing feather duster worm in Figure 12.19 is a polychaete that has a fan-like crown of", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}571{"query": "Denosumab is a human monoclonal antibody which specifically blocks receptor activator of nuclear factor B ligand and is a very potent antiresorptive drug. Its efficacy in reducing the risk of vertebral, hip and nonskeletal fracture has been proven in a large prospective, randomized multicenter study of 7808 postmenopausal women with osteoporosis [Fracture Reduction Evaluation of Denosumab in Osteoporosis Every 6 Months (FREEDOM) trial]. Denosumab causes somewhat greater increases in bone mineral density (BMD) than the class of bisphosphonate antiresorptives. Denosumab also causes an increase in bone mass and bone strength in the spine, ultradistal and diaphysis of the radius, proximal tibia and the hip. Recently long-term treatment with denosumab has been shown to cause a continued almost linear increase in total hip and femoral neck BMD beyond 3 years up to 8 years. In this respect, denosumab seems to differ from the bisphosphonate group in which the rate of improvement of BMD diminishes and for some drugs becomes negative after 3-4 years when the process of secondary mineralization flattens out. This unique property of an antiresorptive drug points towards mechanisms of action which differ from the bisphosphonate group. Both types of antiresorptives decrease cortical porosity but contrary to bisphosphonates the reduction in cortical porosity continues with denosumab which, in addition, also seems to cause a slight continuous modeling-based formation of new bone despite suppression of bone remodeling. The net effect is an increase in cortical thickening and bone mass, and increased strength of cortical bone. This may contribute substantially to the significant further reduction of the nonvertebral fracture risk which was found in the long-term denosumab arm of the FREEDOM extension trial during years 4-7.", "pos": "Patient adherence to many osteoporosis treatments, primarily bisphosphonates, is generally poor, thus leading to a significant reduction in antifracture efficacy. Patient perceptions about the necessity of the prescribed medication to treat osteoporosis and the concerns about the potential adverse effects are important and potentially modifiable determinants of adherence, in addition to other factors, such as difficult dosing regimens and high dosing frequency. Denosumab (Dmab) is a fully human monoclonal antibody against the receptor activator of nuclear factor-B ligand (RANKL), which, through the prevention of the RANKL/RANK interaction, inhibits osteoclast-mediated bone resorption and significantly reduces the risk of vertebral, nonvertebral, and hip fractures. It is administered subcutaneously every 6 months for the treatment of postmenopausal osteoporosis. Preference and adherence to Dmab treatment were assessed in various clinical trials. Although with some limitations, available data suggest that Dmab is preferred to bisphosphonates, produces greater satisfaction than bisphosphonates, and would be preferentially chosen for long-term treatment. Moreover, patient perceptions about the necessity of Dmab treatment clearly outweigh the concerns about the injections, and positive beliefs about treatment positively influence medication-taking behavior. According to these data, Dmab may represent a reasonable alternative to bisphosphonates, particularly for osteoporotic women in whom a suboptimal or even poor adherence to oral treatments is expected.", "neg": "Antisense therapy with both chemistries of phosphorodiamidate morpholino oligomers (PMOs) and 2'-O-methyl phosphorothioate has demonstrated the capability to induce dystrophin expression in Duchenne muscular dystrophy (DMD) patients in phase II-III clinical trials with benefit in muscle functions. However, potential of the therapy for DMD at different stages of the disease progression is not understood. In this study, we examined the effect of peptide-conjugated PMO (PPMO)-mediated exon skipping on disease progression of utrophin-dystrophin-deficient mice (dko) of four age groups (21-29, 30-39, 40-49 and 50+ days), representing diseases from early stage to advanced stage with severe kyphosis. Biweekly intravenous (i.v.) administration of the PPMO restored the dystrophin expression in nearly 100% skeletal muscle fibers in all age groups. This was associated with the restoration of dystrophin-associated proteins including functional glycosylated dystroglycan and neuronal nitric synthase. However, therapeutic outcomes clearly depended on severity of the disease at the time the treatment started. The PPMO treatment alleviated the disease pathology and significantly prolonged the life span of the mice receiving treatment at younger age with mild phenotype. However, restoration of high levels of dystrophin expression failed to prevent disease progression to the mice receiving treatment when disease was already at advanced stage. The results could be critical for design of clinical trials with antisense therapy to DMD.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}572{"query": "The subventricular zone (SVZ) is an embryonic remnant that persists and remains mitotically active throughout adulthood. The rodent SVZ harbors neuronal precursors, principally in its anterior part, and generates neuroblasts that migrate tangentially into the olfactory bulb, thus forming the so-called rostral migratory stream. This study aimed at characterizing the SVZ in the human brain. Antibodies raised against the widely used SVZ molecular markers nestin, glial fibrillary acidic protein, beta-tubulin-III and polysialylated neural cell adhesion molecule, have allowed us to characterize in detail a zone similar to the rodent SVZ in humans. Virtually all portions of the lateral ventricle, as well as the ventral (hypothalamic) sector of the third ventricle, displayed immunoreactivity for most of the molecular markers. The midline region of the septum (septal recess) and the ventral portion of the SVZ displayed a particularly intense immunostaining for all SVZ markers. These two regions may represent zones of adult neurogenesis that are unique to primates. Furthermore, the anti-apoptotic protein Bcl-2 was found to be actively synthesized and co-expressed with all the other markers throughout the entire SVZ. This study reveals that a well-developed SVZ exists in the adult human brain and suggests that Bcl-2 might play an important role in the functional organization of such a system.", "pos": "Since reports that precursor cells in the adult subventricular zone (SVZ) contribute to regenerative neuro- and gliogenesis in CA1, we wondered whether a similar route of migration might also exist under physiological conditions. Permanent labeling of SVZ precursor cells with a lentiviral vector for green fluorescent protein did not reveal any migration from the SVZ into CA1 in the intact murine brain. However, in a nestin-GFP reporter mouse we found proliferating cells within the corpus callosum/alveus region expressing nestin and glial fibrillary acidic protein similar to precursor cells in the neighboring neurogenic region of the adult dentate gyrus. Within 3 weeks of BrdU administration, BrdU-positive nestin-GFP-expressing protoplasmic astrocytes emerged in CA1. Similar to precursor cells isolated from the dentate gyrus and the SVZ, nestin-GFP-expressing cells from corpus callosum/alveus were self-renewing and multipotent in vitro, whereas cells isolated from CA1 were not. Nestin-GFP-expressing cells in CA1 differentiated into postmitotic astrocytes characterized by S100beta expression. No new neurons were found in CA1. The number of nestin-GFP-expressing astrocytes in CA1 was increased by environmental enrichment. We conclude that astrogenesis in CA1 is influenced by environmental conditions. However, SVZ precursor cells do not contribute to physiological cellular plasticity in CA1.", "neg": "During brain development, excess neurons that are formed die by apoptosis. cln3 was recently identified as the gene defective in juvenile Batten disease, an inherited neurodegenerative disease of childhood. In this disease, neurons die by apoptosis. Overexpression of this gene increases survival of human NT2 neuronal precursor cells. We, therefore, hypothesized that cln3 may be present in developing neurons and may play an important role in regulating the developmental process. NT2 neuronal cells were induced to develop into mature neurons. We evaluated cln3 expression by reverse transcription PCR and immunohistochemistry over a 7-wk period of differentiation. Also, cln3 expression was characterized in neonatal rat brain during the first week of life (P-1, P0, P4, and P8) and at P30. cln3 was differentially expressed during neuronal development into nondividing post-mitotic neurons. The greatest expression was noted during wk 6 and then dropped to predifferentiation levels during wk 7. cln3 expression was detected in all the rat brain developmental stages evaluated. The greatest expression was seen at P0 and was double compared with the other stages. We conclude that cln3 is present during critical periods of neuronal cell differentiation and brain development. As cln3 is antiapoptotic, we hypothesize that cln3 plays an important role in regulating brain development. These findings may have implications for identifying strategies aimed at neuroprotection and neuronal survival during development.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}573{"query": "Sr-Vagsy is a former municipality in Sogn og Fjordane county in Norway.", "pos": "The Kungsbacka Fjord (Swedish: Kungsbackafjorden) is a fjord and a nature reserve in Halland County, western Sweden.", "neg": "Bat Wings (Norwegian: Flaggermusvinger) is a 1992 Norwegian drama film directed by Emil Stang Lund.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}574{"query": "The man sitting opposite Robert was the Financial Controller. Everybody called him \"the FC\" for short. He made all the decisions about money. Robert needed some more. That was why he had to see him. The two men did not get on very well. In fact, they had always disliked each other. \"Your request is out of the question,\" the FC said. Robert had difficulty in controlling himself, but he managed somehow. He explained that he wanted the money in order to make more programmes. \"And why do you want to do that?\" the FC asked sharply. Again, Robert almost lost his temper. \"Because more and more people are listening to my department's programmes. There's great demand for them,\" he answered. The FC did not seem to believe him. But Robert had a report on the numbers of listeners to all EBC programmes. The FC became less confident. Robert threw the report down on the table and told him to read it. The FC looked at it in silence. The figures proved that he had been wrong, but he did not want to admit it. \"Well,\" he finally said, \"I may have made a small mistake.\" Robert noticed the word \"may.\" He got up to leave. But he had the feeling that he would get the money after all.", "pos": "The deflated Giants traveled to Minnesota to take on the Vikings. Already eliminated from the playoffs due to Washington beating Philadelphia the night before to secure the NFC East for the first time since 2012, they were without their star wide receiver Odell Beckham Jr. as he was suspended for his actions in a Week 15 loss against Carolina. The Vikings stingy defense put pressure on Eli Manning all game, forcing Tom Coughlin to bench Manning after three interceptions. The Giants defense was not a factor as they failed to contain the Vikings rushing attack all game long. Linebacker JT Thomas was ejected from the game in the 4th quarter for throwing a punch. The loss of Beckham was too steep to overcome and the Giants wound up losing 49-17, dropping to 6-9.", "neg": "A 45-year-old man developed chorea, behavioural changes, moderate amyotrophy and polyneuropathy. Hypertrophic cardiomyopathy and increased serum lactate dehydrogenase and creatine kinase (CK) were found. Acanthocytes were not detected. The absence of XK protein and faintly expressed Kell antigens on erythrocytes were found. Genetic test revealed a R133X mutation of the XK gene, confirming the McLeod syndrome. After 7 years he suddenly developed delirium followed by severe hypoglycaemia, hyperthermia, rhabdomyolysis, hepatic and renal failure. Malignant arrhythmia caused death.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}575{"query": "All rocks on Earth change, but these changes usually happen very slowly. Some changes happen below Earths surface. Some changes happen above ground. These changes are all part of the rock cycle. The rock cycle describes each of the main types of rocks, how they form and how they change. Figure 4.1 shows how the three main rock types are related to each other. The arrows within the circle show how one type of rock may change to rock of another type. For example, igneous rock may break down into small pieces of sediment and become sedimentary rock. Igneous rock may be buried within the Earth and become metamorphic rock. Igneous rock may also change back to molten material and re-cool into a new igneous rock. Rocks are made of minerals. The minerals may be so tiny that you can only see them with a microscope. The minerals may be really large. A rock may be made of only one type of mineral. More often rocks are made of a mixture of different minerals. Rocks are named for the combinations of minerals they are made of and the ways those minerals came together. Remember that different minerals form under different environmental conditions. So the minerals in a rock contain clues about the conditions in which the rock formed (Figure 4.2). Geologists group rocks based on how they were formed. The three main kinds of rocks are: 1. Igneous rocks form when magma cools below Earths surface or lava cools at the surface (Figure 4.3). 2. Sedimentary rocks form when sediments are compacted and cemented together (Figure 4.4). These sediments may be gravel, sand, silt or clay. Sedimentary rocks often have pieces of other rocks in them. Some sedimentary rocks form the solid minerals left behind after a liquid evaporates. 3. Metamorphic rocks form when an existing rock is changed by heat or pressure. The minerals in the rock change but do not melt (Figure 4.5). The rock experiences these changes within the Earth. Rocks can be changed from one type to another, and the rock cycle describes how this happens. Any type of rock can change and become a new type of rock. Magma can cool and crystallize. Existing rocks can be weathered and eroded to form sediments. Rock can change by heat or pressure deep in Earths crust. There are three main processes that can change rock: Cooling and forming crystals. Deep within the Earth, temperatures can get hot enough to melt rock. This molten material is called magma. As it cools, crystals grow, forming an igneous rock. The crystals will grow larger if the magma cools slowly, as it does if it remains deep within the Earth. If the magma cools quickly, the crystals will be very small. Weathering and erosion. Water, wind, ice, and even plants and animals all act to wear down rocks. Over time they can break larger rocks into smaller pieces called sediments. Moving water, wind, and glaciers then carry these pieces from one place to another. The sediments are eventually dropped, or deposited, somewhere. The sediments may then be compacted and cemented together. This forms a sedimentary rock. This whole process can take hundreds or thousands of years. Metamorphism. This long word means to change form. A rock undergoes metamorphism if it is exposed to extreme heat and pressure within the crust. With metamorphism, the rock does not melt all the way. The rock changes due to heat and pressure. A metamorphic rock may have a new mineral composition and/or texture. An interactive rock cycle diagram can be found here: The rock cycle really has no beginning or end. It just continues. The processes involved in the rock cycle take place over hundreds, thousands, or even millions of years. Even though for us rocks are solid and unchanging, they slowly change all the time.", "pos": "Weathering is the process that changes solid rock into sediments. Sediments were described in the chapter \"Ma- terials of Earths Crust.\" With weathering, rock is disintegrated. It breaks into pieces. Once these sediments are separated from the rocks, erosion is the process that moves the sediments. While plate tectonics forces work to build huge mountains and other landscapes, the forces of weathering gradually wear those rocks and landscapes away. Together with erosion, tall mountains turn into hills and even plains. The Appalachian Mountains along the east coast of North America were once as tall as the Himalayas. No human being can watch for millions of years as mountains are built, nor can anyone watch as those same mountains gradually are worn away. But imagine a new sidewalk or road. The new road is smooth and even. Over hundreds of years, it will completely disappear, but what happens over one year? What changes would you see? (Figure 1.1). What forces of weathering wear down that road, or rocks or mountains over time? A once smooth road surface has cracks and fractures, plus a large pothole. Click image to the left or use the URL below. URL:", "neg": "The rock cycle, illustrated in Figure 1.1, depicts how the three major rock types - igneous, sedimentary, and meta- morphic - convert from one to another. Arrows connecting the rock types represent the processes that accomplish these changes. Rocks change as a result of natural processes that are taking place all the time. Most changes happen very slowly. Rocks deep within the Earth are right now becoming other types of rocks. Rocks at the surface are lying in place before they are next exposed to a process that will change them. Even at the surface, we may not notice the changes. The rock cycle has no beginning or end. Rocks are classified into three major groups according to how they form. These three types are described in more detail in other concepts in this chapter, but here is a summary. The Rock Cycle. Igneous rocks form from the cooling and hardening of molten magma in many different environments. The chemical composition of the magma and the rate at which it cools determine what rock forms. Igneous rocks can cool slowly beneath the surface or rapidly at the surface. These rocks are identified by their composition and texture. More than 700 different types of igneous rocks are known. Sedimentary rocks form by the compaction and cementing together of sediments, broken pieces of rock-like gravel, sand, silt, or clay. Those sediments can be formed from the weathering and erosion of preexisting rocks. Sedimentary rocks also include chemical precipitates, the solid materials left behind after a liquid evaporates. Metamorphic rocks form when the minerals in an existing rock are changed by heat or pressure below the surface. Click image to the left or use the URL below. URL: Several processes can turn one type of rock into another type of rock. The key processes of the rock cycle are crystallization, erosion and sedimentation, and metamorphism. Magma cools either underground or on the surface and hardens into an igneous rock. As the magma cools, different crystals form at different temperatures, undergoing crystallization. For example, the mineral olivine crystallizes out of magma at much higher temperatures than quartz. The rate of cooling determines how much time the crystals will have to form. Slow cooling produces larger crystals. Weathering wears rocks at the Earths surface down into smaller pieces. The small fragments are called sediments. Running water, ice, and gravity all transport these sediments from one place to another by erosion. During sedimen- tation, the sediments are laid down or deposited. In order to form a sedimentary rock, the accumulated sediment must become compacted and cemented together. When a rock is exposed to extreme heat and pressure within the Earth but does not melt, the rock becomes meta- morphosed. Metamorphism may change the mineral composition and the texture of the rock. For that reason, a metamorphic rock may have a new mineral composition and/or texture.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}576{"query": "Energy from the Sun comes from the lightest element, hydrogen, fusing together to create the second lightest element, helium. Nuclear fusion on the Sun releases tremendous amounts of solar energy. The energy travels to the Earth, mostly as visible light. The light carries the energy through the empty space between the Sun and the Earth as radiation. Solar energy has been used for power on a small scale for hundreds of years, and plants have used it for billions of years. Unlike energy from fossil fuels, which almost always come from a central power plant or refinery, solar power can be harnessed locally (Figure 1.1). A set of solar panels on a homes rooftop can be used to heat water for a swimming pool or can provide electricity to the house. Societys use of solar power on a larger scale is just starting to increase. Scientists and engineers have very active, ongoing research into new ways to harness energy from the Sun more efficiently. Because of the tremendous amount of incoming sunlight, solar power is being developed in the United States in southeastern California, Nevada, and Arizona. Solar panels supply power to the Interna- tional Space Station. Solar power plants turn sunlight into electricity using a large group of mirrors to focus sunlight on one place, called a receiver (Figure 1.2). A liquid, such as oil or water, flows through this receiver and is heated to a high temperature by the focused sunlight. The heated liquid transfers its heat to a nearby object that is at a lower temperature through a process called conduction. The energy conducted by the heated liquid is used to make electricity. This solar power plant uses mirrors to focus sunlight on the tower in the center. The sunlight heats a liquid inside the tower to a very high temperature, producing energy to make electricity. Solar energy has many benefits. It is extremely abundant, widespread, and will never run out. But there are problems with the widespread use of solar power. Sunlight must be present. Solar power is not useful in locations that are often cloudy or dark. However, storage technology is being developed. The technology needed for solar power is still expensive. An increase in interested customers will provide incentive for companies to research and develop new technologies and to figure out how to mass-produce existing technologies (Figure 1.3). Solar panels require a lot of space. Fortunately, solar panels can be placed on any rooftop to supply at least some of the power required for a home or business. This experimental car is one example of the many uses that engineers have found for solar energy. Click image to the left or use the URL below. URL: Click image to the left or use the URL below. URL:", "pos": "The Sun is Earths main source of energy. The Sun gives us both light and heat. The Sun changes hydrogen into helium through nuclear fusion. This releases huge amounts of energy. The energy travels to the Earth mostly as visible light. The energy is carried through the empty space by radiation. We can use sunlight as an energy resource, called solar energy (Figure 5.7). Solar energy has been used on a small scale for hundreds of years. Today we are using solar energy for more of our power demands. Solar power plants are being built in many locations around the world. In the United States, the southwestern deserts are well suited for solar plants. Sunlight is turned into electricity at a solar power plant. These power plants use a large group of mirrors to focus sunlight on one place. This place is called a receiver (Figure 5.8). At the receiver, a liquid such as oil or water is heated to a high temperature. The liquid transfers its heat by conduction. In conduction, energy moves between two objects that are in contact. The higher temperature object transfers heat to the lower temperature object. For example, when you heat a pot of water on a stove top, energy moves from the pot to its metal handle by conduction. At a solar power plant, the energy conducted by the heated liquid is used to make electricity. Solar energy is used to heat homes and water, and to make electricity. Scientists and engineers have many ways to get energy from the Sun (Figure 5.9). One is by using solar cells. Solar cells are devices that turn sunlight directly into electricity. Lots of solar cells make up an individual solar panel. You may have seen solar panels on roof tops. The Suns heat can also be trapped in your home by using south facing windows and good insulation. Solar energy has many benefits. It does not produce any pollution. There is plenty of it available, much more than we could possibly use. But solar energy has problems. The Sun doesnt shine at night. A special battery is needed to store extra energy during the day for use at night. The technology for most uses of solar energy is still expensive. Until solar technology becomes more affordable, most people will prefer to get their energy from other sources. Moving water has energy (Figure 5.10). That energy is used to make electricity. Hydroelectric power harnesses the energy of water moving down a stream. Hydropower is the most widely used form of renewable energy in the world. This abundant energy source provides almost one fifth of the worlds electricity. The energy of waves and tides can also be used to produce water power. At this time, wave and tidal power are rare. To harness water power, a stream must be dammed. Narrow valleys are the best for dams. While sitting in the reservoir behind the dam, the water has potential energy. Water is allowed to flow downhill into a large turbine. While flowing downhill, the water has kinetic energy. Kinetic energy makes the turbine spin. The turbine is connected to a generator, which makes electricity. Many of the suitable streams in the United States have been developed for hydroelectric power. Many streams worldwide also have hydroelectric plants. Hydropower is a major source of Californias electricity. It accounts for about 14.5 percent of the total. Most of Californias nearly 400 hydroelectric power plants are located in the Sierra Nevada mountains. Water power does not burn a fuel. So it causes less pollution than many other kinds of energy. Water power is also a renewable resource. Water keeps flowing downhill. Although we use some of the energy from this movement, we are not using up the water. Water power does have problems. A large dam stops a streams flow, which floods the land upstream. A beautiful location may be lost. People may be displaced. The dams and turbines also change the downstream environment. Fish and other living things may not be able to survive. Dams slow the release of silt. Downstream deltas retreat and beaches may be starved of sand. Seaside cities may become exposed to storms and", "neg": "Warming homes and other buildings is an obvious way that thermal energy can be used. Two common types of home heating systems are hot-water and warm-air heating systems. Both types are described below. You can watch an animation showing how a solar heating system works at this URL: A hot-water heating system uses thermal energy to heat water and then pumps the hot water throughout the building in a system of pipes and radiators. You can see a diagram of this type of heating system in Figure 18.12. Typically, the water is heated in a boiler that burns natural gas or heating oil. There is usually a radiator in each room that gets warm when the hot water flows through it. The radiator transfers thermal energy to the air around it by conduction and radiation. The warm air then circulates throughout the room in convection currents. The hot water cools as it flows through the system and transfers its thermal energy. When it finally returns to the boiler, it is heated again and the cycle repeats. A warm-air heating system uses thermal energy to heat air. It then forces the warm air through a system of ducts. You can see a diagram of this type of heating system in Figure 18.13. Typically, the air is heated in a furnace that burns natural gas or heating oil. When the air is warm, a fan blows it through the ducts and out through vents that are located in each room. Warm air blowing out of a vent moves across the room, pushing cold air out of the way. The cold air enters an intake vent on the opposite side of the room and returns to the furnace with the help of another fan. In the furnace, the cold air is heated, and the cycle repeats. Its easy to see how thermal energy can be used to keep things warm. But did you know that thermal energy can also be used to keep things cool? Cooling systems such as air conditioners and refrigerators transfer thermal energy in order to keep homes and cars cool or to keep food cold. In a refrigerator, for example, thermal energy is transferred from the cool air inside the refrigerator to the warmer air in the kitchen. You read in this chapters \"Transfer of Thermal Energy\" lesson that thermal energy always moves from a warmer area to a cooler area, so how can it move from the cooler refrigerator to the warmer room? The answer is work. The refrigerator does work to transfer thermal energy in this way. Doing this work takes energy, which is usually provided by electricity. Figure 18.14 explains how a refrigerator does its work. For an animated demonstration of how a refrigerator works, go to this URL: The key to how a refrigerator or other cooling system works is the refrigerant. A refrigerant is a substance, such as FreonTM, that has a low boiling point and changes between liquid and gaseous states as it passes through the cooling system. As a liquid, the refrigerant absorbs thermal energy from the cool air inside the refrigerator and changes to a gas. As a gas, it releases thermal energy to the warm air outside the refrigerator and changes back to a liquid. A combustion engine is a complex machine that burns fuel to produce thermal energy and then uses the energy to do work. Two basic types of combustion engines are external and internal combustion engines. An external combustion engine burns fuel externally, or outside the engine. The burning fuel releases thermal energy that is used to turn water to steam. The pressure of the steam is then used to move a piston back and forth in a cylinder. The kinetic energy of the moving piston can be used to turn a turbine or other device. Figure 18.15 explains in greater detail how this type of engine works. You can see an animated version of an external combustion engine at this URL: [Link] . An internal combustion engine (see Figure 18.16) burns fuel internally, or inside the engine. This type of engine is found in most cars and other motor vehicles. It works in these steps, which keep repeating: 1. A mixture of fuel and air is pulled into a cylinder through a", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}577{"query": "The Pronto Mine is an historical uranium mine located approximately 20 km south of Elliot Lake, Ontario near Spragge.", "pos": "The Premier Mine is an underground diamond mine owned by Petra Diamonds.", "neg": "In late 1532, Sawlon and Thohanbwa marched south and captured Prome.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}578{"query": "When Earth formed 4.6 billion years ago, it would not have been called the water planet. There were no oceans then. In fact, there was no liquid water at all. Early Earth was too hot for liquid water to exist. Earths early years were spent as molten rock and metal. Over time, Earth cooled. The surface hardened to become solid rock. Volcanic eruptions, like the one in Figure 14.1, brought lava and gases to the surface. One of the gases was water vapor. More water vapor came from asteroids and comets that crashed into Earth. As Earth cooled still more, the water vapor condensed to make Earths first liquid water. At last, the oceans could start to form. Earths crust consists of many tectonic plates that move over time. Due to plate tectonics, the continents changed their shapes and positions during Earth history. As the continents changed, so did the oceans. About 250 million years ago, there was one huge land mass known as Pangaea. There was also one huge ocean called Panthalassa. You can see it in Figure 14.2. By 180 million years ago, Pangaea began to break up. The continents started to drift apart. They slowly moved to where they are today. The movement of the continents caused Panthalassa to break into smaller oceans. These oceans are now known as the Pacific, Atlantic, Indian, and Arctic Oceans. The waters of all the oceans are connected. Oceans cover more than 70 percent of Earths surface and hold 97 percent of its surface water. Its no surprise that the oceans have a big influence on the planet. The oceans affect the atmosphere, climate, and living things. Oceans are the major source of water vapor in the atmosphere. Sunlight heats water near the sea surface, as shown in Figure 14.3. As the water warms, some of it evaporates. The water vapor rises into the air, where it may form clouds and precipitation. Precipitation provides the freshwater needed by plants and other living things. Ocean water also absorbs gases from the atmosphere. The most important are oxygen and carbon dioxide. Oxygen is needed by living things in the oceans. Much of the carbon dioxide sinks to the bottom of the seas. Carbon dioxide is a major cause of global warming. By absorbing carbon dioxide, the oceans help control global warming. Coastal areas have a milder climate than inland areas. They are warmer in the winter and cooler in the summer. Thats because land near an ocean is influenced by the temperature of the oceans. The temperature of ocean water is moderate and stable. Why? There are two major reasons: 1. Water is much slower to warm up and cool down than land. As a result, oceans never get as hot or as cold as land. 2. Water flows through all the worlds oceans. Warm water from the equator mixes with cold water from the poles. The mixing of warm and cold water makes the water temperature moderate. Even inland temperatures are milder because of oceans. Without oceans, there would be much bigger temperature swings all over Earth. Temperatures might plunge hundreds of degrees below freezing in the winter. In the summer, lakes and seas might boil! Life as we know it could not exist on Earth without the oceans. The oceans provide a home to many living things. In fact, a greater number of organisms lives in the oceans than on land. Coral reefs, like the one in Figure 14.4, have more diversity of life forms than almost anywhere else on Earth. You know that ocean water is salty. But do you know why? How salty is it? Ocean water is salty because water dissolves minerals out of rocks. This happens whenever water flows over or through rocks. Much of this water and its minerals flow in rivers that end up in the oceans. Minerals dissolved in water form salts. When the water evaporates, it leaves the salts behind. As a result, ocean water is much saltier than other water on Earth. Have you ever gone swimming in the ocean? If you have, then you probably tasted the salts in the water. By", "pos": "Earths outer surface is its crust, a cold, thin, brittle outer shell made of rock. The crust is very thin relative to the radius of the planet. There are two very different types of crust, each with its own distinctive physical and chemical properties, which are summarized in Table 1.1. Crust Oceanic Continental Thickness 5-12 km (3-8 mi) Avg. 35 km (22 mi) Density 3.0 g/cm3 2.7 g/cm3 Composition Mafic Felsic Rock types Basalt and gabbro All types Oceanic crust is composed of mafic magma that erupts on the seafloor to create basalt lava flows or cools deeper down to create the intrusive igneous rock gabbro (Figure 1.1). Gabbro from ocean crust. The gabbro is deformed because of intense faulting at the eruption site. Sediments, primarily mud and the shells of tiny sea creatures, coat the seafloor. Sediment is thickest near the shore, where it comes off the continents in rivers and on wind currents. The oceanic crust is relatively thin and lies above the mantle. The cross section of oceanic crust in the Figure 1.2 shows the layers that grade from sediments at the top to extrusive basalt lava, to the sheeted dikes that feed lava to the surface, to deeper intrusive gabbro, and finally to the mantle. Continental crust is made up of many different types of igneous, metamorphic, and sedimentary rocks. The average composition is granite, which is much less dense than the mafic rocks of the oceanic crust (Figure 1.3). Because it is thick and has relatively low density, continental crust rises higher on the mantle than oceanic crust, which sinks into the mantle to form basins. When filled with water, these basins form the planets oceans. Click image to the left or use the URL below. URL: A cross-section of oceanic crust.", "neg": "Earth formed at the same time as the other planets. The history of Earth is part of the history of the Solar System. Earth came together (accreted) from the cloud of dust and gas known as the solar nebula nearly 4.6 billion years ago, the same time the Sun and the rest of the solar system formed. Gravity caused small bodies of rock and metal orbiting the proto-Sun to smash together to create larger bodies. Over time, the planetoids got larger and larger until they became planets. When Earth first came together it was really hot, hot enough to melt the metal elements that it contained. Earth was so hot for three reasons: Gravitational contraction: As small bodies of rock and metal accreted, the planet grew larger and more massive. Gravity within such an enormous body squeezes the material in its interior so hard that the pressure swells. As Earths internal pressure grew, its temperature also rose. Radioactive decay: Radioactive decay releases heat, and early in the planets history there were many ra- dioactive elements with short half lives. These elements long ago decayed into stable materials, but they were responsible for the release of enormous amounts of heat in the beginning. Bombardment: Ancient impact craters found on the Moon and inner planets indicate that asteroid impacts were common in the early solar system. Earth was struck so much in its first 500 million years that the heat was intense. Very few large objects have struck the planet in the past many hundreds of millions of year. When Earth was entirely molten, gravity drew denser elements to the center and lighter elements rose to the surface. The separation of Earth into layers based on density is known as differentiation. The densest material moved to the center to create the planets dense metallic core. Materials that are intermediate in density became part of the mantle (Figure 1.1). Lighter materials accumulated at the surface of the mantle to become the earliest crust. The first crust was probably basaltic, like the oceanic crust is today. Intense heat from the early core drove rapid and vigorous mantle convection so that crust quickly recycled into the mantle. The recycling of basaltic crust was so effective that no remnants of it are found today. There is not much material to let us know about the earliest days of our planet Earth. What there is comes from three sources: (1) zircon crystals, the oldest materials found on Earth, which show that the age of the earliest crust formed at least 4.4 billion years ago; (2) meteorites that date from the beginning of the solar system, to nearly 4.6 billion years ago (Figure 1.2); and (3) lunar rocks, which represent the early days of the Earth-Moon system as far back as 4.5 billion years ago.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}579{"query": "Different rock types weather at different rates. Certain types of rock are very resistant to weathering. Igneous rocks, especially intrusive igneous rocks such as granite, weather slowly because it is hard for water to penetrate them. Other types of rock, such as limestone, are easily weathered because they dissolve in weak acids. Rocks that resist weathering remain at the surface and form ridges or hills. Shiprock in New Mexico is the throat of a volcano thats left after the rest of the volcano eroded away. The rock thats left behind is magma that cooled relatively slowly and is harder than the rock that had surrounded it. Different minerals also weather at different rates. Some minerals in a rock might completely dissolve in water, but the more resistant minerals remain. In this case, the rocks surface becomes pitted and rough. When a less resistant mineral dissolves, more resistant mineral grains are released from the rock. A beautiful example of this effect is the \"Stone Forest\" in China, see the video below: The Shiprock formation in northwest New Mexico is the central plug of resistant lava from which the surrounding rock weath- ered and eroded away. Click image to the left or use the URL below. URL: A regions climate strongly influences weathering. Climate is determined by the temperature of a region plus the amount of precipitation it receives. Climate is weather averaged over a long period of time. Chemical weathering increases as: Temperature increases: Chemical reactions proceed more rapidly at higher temperatures. For each 10o C increase in average temperature, the rate of chemical reactions doubles. Precipitation increases: More water allows more chemical reactions. Since water participates in both mechan- ical and chemical weathering, more water strongly increases weathering. So how do different climates influence weathering? A cold, dry climate will produce the lowest rate of weathering. A warm, wet climate will produce the highest rate of weathering. The warmer a climate is, the more types of vegetation it will have and the greater the rate of biological weathering (Figure 1.2). This happens because plants and bacteria grow and multiply faster in warmer temperatures. Some resources are concentrated by weathering processes. In tropical climates, intense chemical weathering carries away all soluble minerals, leaving behind just the least soluble components. The aluminum oxide, bauxite, forms this way and is our main source of aluminum ore.", "pos": "All rocks on Earth change, but these changes usually happen very slowly. Some changes happen below Earths surface. Some changes happen above ground. These changes are all part of the rock cycle. The rock cycle describes each of the main types of rocks, how they form and how they change. Figure 4.1 shows how the three main rock types are related to each other. The arrows within the circle show how one type of rock may change to rock of another type. For example, igneous rock may break down into small pieces of sediment and become sedimentary rock. Igneous rock may be buried within the Earth and become metamorphic rock. Igneous rock may also change back to molten material and re-cool into a new igneous rock. Rocks are made of minerals. The minerals may be so tiny that you can only see them with a microscope. The minerals may be really large. A rock may be made of only one type of mineral. More often rocks are made of a mixture of different minerals. Rocks are named for the combinations of minerals they are made of and the ways those minerals came together. Remember that different minerals form under different environmental conditions. So the minerals in a rock contain clues about the conditions in which the rock formed (Figure 4.2). Geologists group rocks based on how they were formed. The three main kinds of rocks are: 1. Igneous rocks form when magma cools below Earths surface or lava cools at the surface (Figure 4.3). 2. Sedimentary rocks form when sediments are compacted and cemented together (Figure 4.4). These sediments may be gravel, sand, silt or clay. Sedimentary rocks often have pieces of other rocks in them. Some sedimentary rocks form the solid minerals left behind after a liquid evaporates. 3. Metamorphic rocks form when an existing rock is changed by heat or pressure. The minerals in the rock change but do not melt (Figure 4.5). The rock experiences these changes within the Earth. Rocks can be changed from one type to another, and the rock cycle describes how this happens. Any type of rock can change and become a new type of rock. Magma can cool and crystallize. Existing rocks can be weathered and eroded to form sediments. Rock can change by heat or pressure deep in Earths crust. There are three main processes that can change rock: Cooling and forming crystals. Deep within the Earth, temperatures can get hot enough to melt rock. This molten material is called magma. As it cools, crystals grow, forming an igneous rock. The crystals will grow larger if the magma cools slowly, as it does if it remains deep within the Earth. If the magma cools quickly, the crystals will be very small. Weathering and erosion. Water, wind, ice, and even plants and animals all act to wear down rocks. Over time they can break larger rocks into smaller pieces called sediments. Moving water, wind, and glaciers then carry these pieces from one place to another. The sediments are eventually dropped, or deposited, somewhere. The sediments may then be compacted and cemented together. This forms a sedimentary rock. This whole process can take hundreds or thousands of years. Metamorphism. This long word means to change form. A rock undergoes metamorphism if it is exposed to extreme heat and pressure within the crust. With metamorphism, the rock does not melt all the way. The rock changes due to heat and pressure. A metamorphic rock may have a new mineral composition and/or texture. An interactive rock cycle diagram can be found here: The rock cycle really has no beginning or end. It just continues. The processes involved in the rock cycle take place over hundreds, thousands, or even millions of years. Even though for us rocks are solid and unchanging, they slowly change all the time.", "neg": "A rock is a naturally formed, non-living Earth material. Rocks are made of collections of mineral grains that are held together in a firm, solid mass (Figure 1.1). How is a rock different from a mineral? Rocks are made of minerals. The mineral grains in a rock may be so tiny that you can only see them with a microscope, or they may be as big as your fingernail or even your finger (Figure Rocks are identified primarily by the minerals they contain and by their texture. Each type of rock has a distinctive set of minerals. A rock may be made of grains of all one mineral type, such as quartzite. Much more commonly, rocks are made of a mixture of different minerals. Texture is a description of the size, shape, and arrangement of mineral grains. Are the two samples in Figure 1.3 the same rock type? Do they have the same minerals? The same texture? The different colors and textures seen in this rock are caused by the presence of different minerals. A pegmatite from South Dakota with crystals of lepidolite, tourmaline, and quartz (1 cm scale on the upper left). Sample 2 Crystals are tiny or microscopic Magma erupted and cooled quickly Andesite As seen in Table 1.1, these two rocks have the same chemical composition and contain mostly the same minerals, but they do not have the same texture. Sample 1 has visible mineral grains, but Sample 2 has very tiny or invisible grains. The two different textures indicate different histories. Sample 1 is a diorite, a rock that cooled slowly from magma (molten rock) underground. Sample 2 is an andesite, a rock that cooled rapidly from a very similar magma that erupted onto Earths surface. A few rocks are not made of minerals because the material they are made of does not fit the definition of a mineral. Coal, for example, is made of organic material, which is not a mineral. Can you think of other rocks that are not made of minerals? Click image to the left or use the URL below. URL: Click image to the left or use the URL below. URL:", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}580{"query": "A sexually transmitted infection (STI) is a disease that spreads mainly through sexual contact. STIs are caused by pathogens that enter the body through the reproductive organs. Many STIs also spread through body fluids such as blood. For example, a shared tattoo needle is one way that some STIs can spread. Some STIs can also spread from a mother to her infant during birth. STIs are more common in teens and young adults than in older people. One reason is that young people are more likely to engage in risky behaviors. They also may not know how STIs spread. Instead, they may believe myths about STIs, like those in Table 22.1. Knowing the facts is important to prevent the spread of STIs. Myth If you are sexually active with just one person, then you cant get STIs. If you dont have any symptoms, then you dont have an STI. Getting STIs is no big deal, because they can be cured with medicines. Fact The only sure way to avoid getting STIs is to practice abstinence from sexual activity. Many STIs do not cause symptoms, especially in fe- males. Only some STIs can be cured with medicines; others cannot be cured. A number of STIs are caused by bacteria. Bacterial STIs can usually be cured with antibiotics. However, some people with bacterial STIs may not have symptoms so they fail to get treatment. Left untreated, these infections may damage reproductive organs and lead to an inability to have children. Three bacterial STIs are chlamydia, gonorrhea, and syphilis. Chlamydia is the most common bacterial STI in the U.S. Females are more likely to develop it than males. Symptoms may include burning during urination and a discharge from the vagina or penis. Gonorrhea is another common bacterial STI. Symptoms may include painful urination and a discharge from the vagina or penis. Syphilis is a very serious STI but somewhat less common than chlamydia or gonorrhea. It usually begins with a small sore on the genitals. This is followed a few months later by a rash and flu-like symptoms. If syphilis isnt treated, it can eventually damage the heart, brain, and other organs and even cause death. Several STIs are caused by viruses. Viral STIs cant be cured with antibiotics. Other drugs may help control the symptoms of viral STIs, but the infections usually last for life. Three viral STIs are genital warts, genital herpes, and AIDS. Genital herpes is a common STI caused by a herpes virus. The virus causes painful blisters on the penis or near the vaginal opening. The blisters generally go away on their own, but they may return repeatedly throughout life. There is no cure for genital herpes, but medicines can help prevent or shorten outbreaks. Acquired Immunodeficiency Syndrome (AIDS) is caused by human immunodeficiency virus (HIV). HIV destroys lymphocytes that normally fight infections. AIDS develops if the number of lymphocytes drops to a very low level. People with AIDS come down with diseasessuch as certain rare cancersthat almost never occur in people with a healthy immune system. Medicines can delay the progression of an HIV infection and may prevent AIDS from developing. Genital warts is an STI caused by human papilloma virus (HPV), which is pictured in Figure 22.15. This is one of the most common STIs in U.S. teens. Genital warts cant be cured, but a vaccine can prevent most HPV infections. The vaccine is recommended for boys and girls starting at 11 or 12 years of age. Its important to prevent HPV infections because they may lead to cancer later in life. Other reproductive system disorders include injuries and noninfectious diseases. These are different in males and females. Most common disorders of the male reproductive system involve the testes. They include injuries and cancer. Injuries to the testes are very common. In teens, such injuries occur most often while playing sports. Injuries to the testes are likely to be very painful and cause bruising and swelling. However, they generally subside fairly quickly. Cancer of the testes is most common in males aged 15 to 35. It occurs when cells in the testes grow out of control and form a tumor. If found early", "pos": "A sexually transmitted infection (STI) is an infection that spreads through sexual contact. STIs are caused by pathogens, a living thing or virus that causes infection. The pathogens enter the body through the reproductive organs. Many STIs also spread through body fluids, such as blood. For example, a shared tattoo needle is one way an STI could spread. Some STIs can also spread from a mother to her baby during childbirth. STIs are more common in teens and young adults than in older people. One reason is that young people are more likely to take risks. They also may not know how STIs spread. They are likely to believe myths about STIs ( Table Myth If you are sexually active with just one person, you cant get STIs. If you dont have any symptoms, then you dont have an STI. Getting STIs is no big deal, because STIs can be cured with medicine. Fact The only way to avoid the risk of STIs is to practice abstinence from sexual activity. Many STIs do not cause symptoms, especially in fe- males. Only some STIs can be cured with medicine; other STIs cannot be cured. Most STIs are caused by bacteria or viruses. STIs caused by bacteria usually can be cured with drugs called antibiotics. But antibiotics are not effective against viruses. Therefore, STIs caused by viruses are not treated with antibiotics. Other drugs may be used to help control the symptoms of viral STIs, but they cannot be cured. Once you have a viral STI, you are usually infected for life. In the U.S., chlamydia is the most common STI caused by bacteria. Females are more likely than males to develop the infection. Rates of chlamydia among U.S. females in 2006 are shown below ( Figure 1.1). Rates were much higher in teens and young women than in other age groups. Chlamydia may cause a burning feeling during urination. It may also cause a discharge (leaking of fluids) from the vagina or penis. But in many cases it causes no symptoms. As a result, people do not know they are infected, so they dont go to the doctor for help. If chlamydia goes untreated, it may cause more serious problems in females. It may cause infections of the uterus, fallopian tubes, or ovaries. These infections may leave a woman unable to have children. Gonorrhea is another common STI. Gonorrhea may cause pain during urination. It may also cause a discharge from the vagina or penis. On the other hand, some people with gonorrhea have no symptoms. As a result, they dont seek treatment. Without treatment, gonorrhea may lead to infection of other reproductive organs. This can happen in males as well as females. Syphilis is a very serious STI. Luckily, it is less common than chlamydia or gonorrhea. Syphilis usually begins with a small sore on the genitals. This is followed a few months later by a rash and flu-like symptoms. If syphilis is not treated, it may damage the heart, brain, and other organs. It can even cause death. Genital warts are an STI caused by human papilloma virus, or HPV. They are one of the most common STIs in teenagers. HPV infections cannot be cured. But a new vaccine called Gardasil can prevent most HPV infections in females. Many doctors recommend that females between the ages of 9 and 26 years receive the vaccine. Preventing HPV infections in females is important because HPV can also cause cancer of the cervix. A related herpes virus causes cold sores on the lips ( Figure 1.2). Both viruses cause painful blisters. In the case of genital herpes, the blisters are on the penis or around the vaginal opening. The blisters go away on their own, but the virus remains in the body. The blisters may come back repeatedly, especially when a person is under stress. There is no cure for genital herpes. But drugs can help prevent or shorten outbreaks. Researchers are trying to find a vaccine to prevent genital herpes. Hepatitis B is a disease of the liver. It is caused by a virus called hepatitis B, which can be passed through sexual activity", "neg": "HIV, or human immunodeficiency virus, causes AIDS. AIDS stands for \"acquired immune deficiency syndrome.\" It is a condition that causes death and does not have a known cure. AIDS usually develops 10 to 15 years after a person is first infected with HIV. The development of AIDS can be delayed with proper medicines. The delay can be well over 20 years with the right medicines. Today, individuals who acquire HIV after 50 years of age can expect to reach an average human life span. HIV spreads through contact between an infected persons body fluids and another persons bloodstream or mucus membranes, which are found in the mouth, nose, and genital areas. Body fluids that may contain HIV are blood, semen, vaginal fluid, and breast milk. The virus can spread through sexual contact or shared drug needles. It can also spread from an infected mother to her baby during childbirth or breastfeeding. Saliva can carry the HIV virus, but it wont spread it, unless the saliva gets into the bloodstream. Other body fluids such as urine and sweat do not contain the virus. HIV does not spread in any fluid in which the host cells cannot survive. Some people think they can become infected with HIV by donating blood or receiving donated blood. This is not true. The needles used to draw blood for donations are always new. Therefore, they cannot spread the virus. Donated blood is also tested to make sure it is does not contain HIV. HIV is not transmitted by day-to-day contact in the workplace, schools, or social settings. HIV is not transmitted through shaking hands, hugging, or a casual kiss. You cannot become infected from a toilet seat, a drinking fountain, a door knob, dishes, drinking glasses, food, or pets. How does an HIV infection develop into AIDS? HIV destroys white blood cells called helper T cells. The cells are produced by the immune system. This is the body system that fights infections and other diseases. HIV invades helper T cells and uses them to produce more virus particles ( Figure 1.1). Then, the virus kills the helper T cells. As the number of viruses in the blood rises, the number of helper T cells falls. Without helper T cells, the immune system is unable to protect the body. The infected person cannot fight infections and other diseases because they do not have T cells. This is why people do not die from HIV. Instead, they die from another illness, like the common cold, that they cannot fight because they do not have helper T cells. Medications can slow down the increase of viruses in the blood. But the medications cannot remove the viruses from the body. At present, there is no cure for HIV infection. A vaccine against HIV could stop this disease, and such a vaccine is in development, though it could take many years before it can be given to prevent this virus. AIDS is not really a single disease. It is a set of symptoms and other diseases. It results from years of damage to the immune system by HIV. AIDS occurs when helper T cells fall to a very low level, making it difficult for the affected person to fight various diseases and other infections. These people develop infections or cancers that people with a healthy immune systems can easily resist. These diseases are usually the cause of death of people with AIDS. The first known cases of AIDS occurred in 1981. Since then, AIDS has led to the deaths of more than 35 million people worldwide. Many of them were children. The greatest number of deaths occurred in Africa. It is also where medications to control HIV are least available. There are currently more people infected with HIV in Africa than any other part of the world. Well over 30 million people are living with HIV worldwide.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}581{"query": "Count Lasher entered some of the music competitions held regularly at Jamaica's Ward's Theatre.", "pos": "Thomas Magnay (14 September 1876 -- 3 November 1949) was a Liberal Party politician in the United Kingdom, who joined the breakaway Liberal National faction and served as a Member of Parliament (MP) from 1931 to 1945.", "neg": "Prelude and Fugue in A minor, BWV 543 is a piece of organ music written by Johann Sebastian Bach sometime around his years as court organist to the Duke of Saxe-Weimar (1708--1717).", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}582{"query": "Kate Forster is a Doctor in 2006, living alone in Chicago. She has moved into an apartment after living in a house built next to a scenic lake in a secluded countryside area. She writes a letter to the next tenant asking that they forward any mail, and that the paw prints and the box in the attic have always been there. The tenant Alex Wyler reads the letter, but finds no paw prints, no box and no sign of life within the last 5 years, so disregards the letter until a few days later when he is redoing the paint on the handrails and a stray dog, whom Alex takes in and names Jack although the dog is female, trots through the brown paint and leaves its paw prints all the way to the front door. He writes to Kate asking more about these incidents and leaves the letter in the mail box.On Valentine's Day 2006, Kate visits the Lake House after having a gentleman die in her arms after being hit by a bus, but finds the Mail Box Flag is up. She reads Alex's letter and states her current address, also stating it is 2006, not 2004 from which Alex's letter arrives from. Alex attends her 'current address' but finds a construction site that won't be finished for another 18 months, and they both slowly realize they are communicating from two years apart, with only the Mailbox to communicate from.As Kate and Alex continue to correspond through the mailbox, they find themselves falling in love. Because Kate is in the future, she can tell Alex specific places to look for her in 2004. On one occasion, she asks Alex to bring her back something important (a gift from her father; her favorite novel by Jane Austen called Persuasion), which she left two years ago during a train station meeting with her then-beau, Morgan. Alex goes to the station and finds the item and sees Kate with long hair. Even though he has the item, he does not place it in the mailbox to return it to her. Instead, he says that he will return it to her personally, \"one way or the other.\" Alex sends her a personalized map of Chicago and takes her on a walking tour of his favorite places in the city one Saturday morning. He leaves her a loving message on a brick wall at the end written in 2004, that she sees in 2006. The message was \"Kate, I am here with you. thank you for spending this Saturday together\".In 2004, Mona, a young attractive assistant, is flirting with Alex but he ignores her advances. Alex's dog Jack runs off and leads Alex to a house in which Morgan and Kate are currently living. Alex talks with Morgan and eventually is invited to the birthday party Morgan is holding for Kate that evening. During the party, Alex and Kate dance together and share a romantic kiss, which is broken up by Morgan and Mona. Later, Kate and Alex discuss that night and Kate announces she liked him, and can remember what he looks like.Crisis enters Alex's life when his estranged father has a heart attack and shortly thereafter dies. Kate somehow discovers his death certificate at the time he dies. She rushes to the mailbox and as a gift to Alex, she places a book in the mailbox, which she says is a tribute to his father, a book that is not yet published in Alex's time.Determined to bridge the distance between them at last and unravel the mystery behind their extraordinary connection, they tempt fate by arranging to meet. Alex makes a reservation in 2004 for a date in 2006 at Il Mare, a fancy restaurant, but only Kate appears. Alex does not show up. The next day Kate writes Alex a letter telling Alex of this fact, but he doesn't understand. \"Something must have happened\" he responds. Kate retreats, believing she will never have happiness. She urges Alex to move on She tells him about Valentine's Day 2006 when a man died \"in her arms\", and that she needs to live her own life. She asks Alex not to contact her", "pos": "Cynthia Nelson (Mariette Hartley), a teacher at the local orphanage, talks with a pastor while watching the sun set before getting ready for a fundraising costume party. Cynthia mentions the \"Santa Ana winds\" which the pastor states are an evil omen. One the orphans, Tommy, wanders into the nearby cemetery where he faintly hears a voice ordering \"To rise; it is time.\" Vampire women rise from their graves and chase Tommy into the clutches of Count Yorga, who was waiting for them. Yorga, having been in the area while creating his undead harem and hiding them in the cemetery, has purchased a manor next to the orphanage. His intent is to prey on the children and staff there to satisfy his and his vampire-brides' thirst for blood and presumably create an undead-army from the community's women. In his human guise, he goes to the orphanage during their costume party and fund raiser, biting on of the guests, Mitzi, outside the event room before introducing himself to those present to which he meets and becomes smitten with Cynthia. Upon returning to his manor and a throne room of sorts where he's greeted by his Brudah and his female vampire servants, sends his undead brides to her house, using mind-control to get Cynthia's family into one room before having the brides break in and attack them. Cynthia's father and mother are killed after being drained of their blood, while Cynthia's sister, Ellen, is fed upon and transformed into a new vampire bride to serve Yorga. Tommy, who was sleeping over, is untouched having fallen under Yorga's power, and blankly looks on as the carnage unfolds. Cynthia is subdued (though not bitten) and carried by the brides to Yorga's residence where she awakens with no memory of the attack. Yorga tells Cynthia that her family were in a car accident and she was left in his care during their recovery. Yorga tries to charm the young woman into willingly becoming his bride though he is warned by his live-in witch that Cynthia will bring his end if he doesn't kill her or turn her into a vampire soon. The next morning, Jennifer, the Nelsons' mute maid, finds the massacre scene and calls the police. By the time the police arrive though, all of the evidence has been mysteriously cleared away, and Tommy claims that nothing has happened. Later that same morning, Bruddah, Yorga's hulking, facially disfigured servant (like Yorga, also returning from an on-screen death in the first film) drags the corpses of Cynthia's mother and father to a quicksand pit on Yorga's property, disposing of the physical evidence while likewise bring Ellen's body to Yorga to complete her transformation. Despite the confusion, David Baldwin, Cynthia's fiance, is suspicious about the Nelsons' disappearance. Meanwhile, memories of the attack on her family slowly start to resurface in Cynthia's mind as she stays within Yorga's manor. Jennifer, suspicious about Tommy's involvement with the Nelson's disappearance and his visits to Yorga's mansion, loses her patience and slaps Tommy who stares at her in a vengeful manner. Meanwhile, Yorga goes to claim Mitzi, killing her boyfriend near their boat house then biting her, draining her blood and making her a new bride. Hours later, Ellen's fiance Jason is lured to Yorga's mansion by Tommy, on the promise that he would find Ellen. Once at the mansion, Tommy disappears, while Jason is reunited with Ellen. However, in her vampirized state, she is now evil and laughs at him for \"not loving her anymore\", distracting him before her fellow brides attack him from behind. Jason breaks free, only to run into Count Yorga, who chases Jason down a hall and strangles him. Bruddah tosses Jason's body into the throne/coffin room for the brides, including Ellen and newly vampiric Mitzi, to feed upon. That evening, Reverend Thomas phones Jennifer, but it is revealed she lay dead on her bed with a large knife sticking out of her chest. From her window, Tommy can be seen walking", "neg": "As elderly people go about their day in Manhattan, Harry walks along a sidewalk with his tabby cat Tonto on a leash, quoting Shakespeare's \"King Lear\" as he goes. Harry stops in at a grocer, buys some good food for his cat, and jokes that his sexual days are over.Next Harry meets his old friend Jacob on a bench, and tells him that his apartment building is being torn down to build a parking lot. Jacob complains about capitalists, and reassures Harry that he could always move in with him.On the way home, a kid tries to steal Harry's groceries and knocks him down. Harry is helped up by Leroy, his building super.Harry gets into his apartment and talks to Tonto, lamenting that he's been mugged four times in the past year, and that the whole city is getting run down.Some time later, police show up to forcibly remove Harry and his furniture from the building. Harry continues to spout \"King Lear\" while his son Burt arrives to pick him up.Harry goes to live with Burt and his wife and two grown sons in the suburbs. His younger grandson, Norman, has taken a vow of silence, leading to obvious tension with his brother and parents. Harry later asks Norman for the books that explain his beliefs.Harry goes back to his familiar bench to talk with Jacob, and they both agree it's been a long time since either has been with a woman. Jacob reminisces about his first sexual encounter with a servant girl when he was 14.Harry invites Leroy to dinner at Burt's house, and he plays the piano while Leroy dances to the tune. Leroy later comments that he lives with his 90-year-old mother and can't find a new job, which leads Burt's wife to question why Harry is not getting help from his two other kids.Knowing that he is a burden to Burt, Harry goes to look for his own apartment, but finds that the place he wants will not take cats. He then tells Burt he is going to Chicago to visit Shirley, Burt's sister, but before he leaves he stops at a city morgue to identify the body of Jacob, who has died with no relatives. Harry cries after recalling Jacob's story of losing his virginity.Burt takes Harry to the airport, but Harry soon learns that he can't go through security with Tonto, so he takes a cab to get a bus. Along the route, Harry asks the bus driver to stop so that Tonto can relieve himself, whereupon the cat runs away across a cemetery. The bus driver leaves Harry behind with his luggage, and when Tonto returns, Harry scolds him.Harry walks to a used car lot and buys an old Chevy for $250. He then checks into a motel and calls Burt to tell him what has happened, realizing in the process that his driver's license expired in 1958.Harry drives west rather slowly, with Tonto on the dashboard, recalling how he wanted to drive across the country when he was younger, but his wife and kids came along. He remembers they had many good times though. He confesses to Tonto that he has a great fear of pain, and that when he dies he would like to go quickly rather than the slow way his wife Annie died.Harry picks up two young hitchhikers, one of whom soon gets another ride, while the other a girl named Ginger continues west with Harry. She claims she is 16, and is running away from home to a commune in Boulder.Harry and Ginger get a motel for the night, and after she comes out of the bathroom half-naked, Harry is prompted to recall the first girl he loved, Jessie, whom he has not seen in 50 years. Ginger suggests that they go to see her, even though it's out of their way, and they eventually find her in a nursing home.At first Harry thinks Jessie remembers him, but her thoughts are marked by senility; she calls him Alex yet remembers his wife Annie. Then she suddenly asks Harry to dance, which they do while Ginger looks on.Harry", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}583{"query": "Mutations in the K-ras oncogene and in the p53 tumor suppressor gene are commonly identified in sporadic cases of pancreatic adenocarcinoma. Although these genes might serve as useful markers for early diagnosis of pancreatic carcinoma in patients at risk for the development of this disease, familial pancreatic carcinomas have not been studied for these mutations. We recently had the opportunity to examine a pancreas prophylactically removed from a patient with a strong family history of pancreatic carcinoma. This gave us the unique opportunity to study the early events in the development of familial adenocarcinoma of the pancreas. Histopathological examination of the pancreas revealed multifocal papillary and nonpapillary mucinous duct hyperplasia. Seven of these foci were microdissected and analyzed for K-ras and p53 mutations. The K-ras mutations were detected by combined mutant-enriched polymerase chain reaction-restriction fragment length polymorphism analysis and characterized further by allele-specific oligonucleotide hybridization. Five of the seven duct lesions harbored activating point mutations in codon 12 of K-ras; a G to A transition was found in four and a G to C transversion in one. In contrast, these lesions did not harbor detectable p53 mutations as determined by denaturing gradient gel electrophoresis of exons 5 to 8, nor was there overexpression of the p53 protein as determined by immunohistochemistry. These findings suggest that mutations in K-ras represent an early event in the pathogenesis of pancreatic carcinoma. In addition, monitoring of patients with a strong family history of pancreatic carcinoma for K-ras mutations may identify patients at risk for the development of invasive carcinoma.", "pos": "Activating point mutations in the K-Ras oncogene are among the most common genetic alterations in pancreatic cancer, occurring early in the progression of the disease. However, the function of mutant K-Ras activity in tumor angiogenesis remains poorly understood. Using human pancreatic duct epithelial (HPDE) and K-Ras4B(G12V)-transformed HPDE (HPDE-KRas) cells, we show that activated K-Ras significantly enhanced the production of angiogenic factors including CXC chemokines and vascular endothelial growth factor (VEGF). Western blot analysis revealed that K-Ras activation promoted the phosphorylation of Raf/mitogen-activated protein kinase kinase-1/2 (MEK1/2) and expression of c-Jun. MEK1/2 inhibitors, U0126 and PD98059, significantly inhibited the secretion of both CXC chemokines and VEGF, whereas the c-Jun NH(2)-terminal kinase inhibitor SP600125 abrogated only CXC chemokine production. To further elucidate the biological functions of oncogenic K-Ras in promoting angiogenesis, we did in vitro invasion and tube formation assays using human umbilical vein endothelial cells (HUVEC). HUVEC cocultured with HPDE-KRas showed significantly enhanced invasiveness and tube formation as compared with either control (without coculture) or coculture with HPDE. Moreover, SB225002 (a CXCR2 inhibitor) and 2C3 (an anti-VEGF monoclonal antibody) either alone or in a cooperative manner significantly reduced the degree of both Ras-dependent HUVEC invasiveness and tube formation. Similar results were obtained using another pair of immortalized human pancreatic duct-derived cells, E6/E7/st and its oncogenic K-Ras variant, E6/E7/Ras/st. Taken together, our results suggest that angiogenesis is initiated by paracrine epithelial secretion of CXC chemokines and VEGF downstream of activated oncogenic K-Ras, and that this vascular maturation is in part dependent on MEK1/2 and c-Jun signaling.", "neg": "Change in gene expression associated with pancreatic cancer could be attributed to the variation in histone posttranslational modifications leading to subsequent remodeling of the chromatin template during transcription. However, the interconnected network of molecules involved in regulating such processes remains elusive. hPaf1/PD2, a subunit of the human PAF-complex, involved in the regulation of transcriptional elongation has oncogenic potential. Our study explores the possibility that regulation of histone methylation by hPaf1 can contribute towards alteration in gene expression by nucleosomal rearrangement. Here, we show that knockdown of hPaf1/PD2 leads to decreased di- and tri-methylation at histone H3 lysine 4 residues in pancreatic cancer cells. Interestingly, hPaf1/PD2 colocalizes with MLL1 (Mixed Lineage Leukemia 1), a histone methyltransferase that methylates H3K4 residues. Also, a reduction in hPaf1 level resulted in reduced MLL1 expression and a corresponding decrease in the level of CHD1 (Chromohelicase DNA-binding protein 1), an ATPase dependent chromatin remodeling enzyme that specifically binds to H3K4 di and trimethyl marks. hPaf1/PD2 was also found to interact and colocalize with CHD1 in both cytoplasmic and nuclear extracts of pancreatic cancer cells. Further, reduced level of CHD1 localization in the nucleus in hPaf1/PD2 Knockdown cells could be rescued by ectopic expression of hPaf1/PD2. Micrococcal nuclease digestion showed an altered chromatin structure in hPaf1/PD2-KD cells. Overall, our results suggest that hPaf1/PD2 in association with MLL1 regulates methylation of H3K4 residues, as well as interacts and regulates nuclear shuttling of chromatin remodeling protein CHD1, facilitating its function in pancreatic cancer cells.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}584{"query": "In a New York City courthouse, an eighteen-year-old boy from a slum is on trial for allegedly stabbing his father to death. Final closing arguments having been presented, a visibly bored judge instructs the jury to decide whether the boy is guilty of murder. If there is any reasonable doubt of his guilt they are to return a verdict of not guilty. The judge further informs them that a guilty verdict will be accompanied by a mandatory death sentence.The jury retires to a private room, where the jurors spend a short while getting acquainted before they begin deliberating. It is immediately apparent that the jurors have already decided that the boy is guilty, and that they plan to return their verdict without taking time for discussion with the sole exception of Juror 8 (Henry Fonda), who is the only \"not guilty\" vote in a preliminary tally. He explains that there is too much at stake for him to go along with the verdict without at least talking about it first. His vote annoys the other jurors, especially Juror 7 (Jack Warden), who has tickets to a baseball game that evening; and Juror 10 (Ed Begley Sr.), who believes that people from slum backgrounds are liars, wild, and dangerous.The rest of the film's focus is the jury's difficulty in reaching a unanimous verdict. While several of the jurors harbor personal prejudices, Juror 8 maintains that the evidence presented in the case is circumstantial, and that the boy deserves a fair deliberation. He calls into question the accuracy and reliability of the only two witnesses to the murder, the \"rarity\" of the murder weapon (a common switchblade, of which he has an identical copy), and the overall questionable circumstances. He further argues that he cannot in good conscience vote \"guilty\" when he feels there is reasonable doubt of the boy's guilt.Having argued several points and gotten no favorable response from the others, Juror 8 reluctantly agrees that he has only succeeded in hanging the jury. Instead, he requests another vote, this time by secret ballot. He proposes that he will abstain from voting, and if the other 11 jurors are still unanimous in a guilty vote, then he will acquiesce to their decision. The secret ballot is held, and a new \"not guilty\" vote appears. This earns intense criticism from Juror 3 (Lee J. Cobb), who blatantly accuses Juror 5 (Jack Klugman) who had grown up in a slum of switching out of sympathy toward slum children. However, Juror 9 (Joseph Sweeney) reveals that he himself changed his vote, feeling that Juror 8's points deserve further discussion.Juror 8 presents a convincing argument that one of the witnesses, an elderly man who claimed to have heard the boy yell \"I'm going to kill you\" shortly before the murder took place, could not have heard the voices as clearly as he had testified due to an elevated train passing by at the time; as well as stating that \"I'm going to kill you,\" is often said by people who do not literally mean it. Juror 5 changes his vote to \"not guilty\". Soon afterward, Juror 11 (George Voskovec) questions whether it is reasonable to suppose the defendant would have fled the scene, having cleaned the knife of fingerprints but leaving it behind, and then come back three hours later to retrieve it (having been left in his father's chest). Juror 11 then changes his vote.Juror 8 then mentions the man's second claim: upon hearing the father's body hit the floor, he had run to the door of his apartment and seen the defendant running out of the building from his front door in 15 seconds. Jurors 5, 6 and 8 question whether this is true, as the witness in question had had a stroke, limiting his ability to walk. Upon the end of an experiment, the jury finds that the witness would not have made it to the door in enough time to actually see the killer running out. Juror 8 concludes that, judging from what he claims to have heard earlier, the witness must have", "pos": "A Huey helicopter flies over the Alaskan wilderness, its pilots looking for someone below. That someone, Major Mitchell Gant USAF (Rtd) (Clint Eastwood), hears the helicopter approaching and instantly breaks into a dead run back toward his cabin, where he takes a shotgun off its rack and cocks it. As the helicopter lands, Gant lapses into a post-tramautic memory of a nightmare that he lived through in Vietnam: shot down over the North in his A-4, he was being taken to a prison camp when two Hueys machine-gunned his captors. Gant suffered personal trauma when an overflying A-4 dropped an incendiary on the site, killing a little girl who stood around too long, watching the battle. Back in the present, Captain Arthur Buckholz (David Huffman) pulls Gant out of his episode and apologizes for the surprise.The next several scenes are back-and-forth cuts between the conversation between Gant and Buckholz, and a briefing being run by Kenneth Aubrey (Freddie Jones) of the British SIS concerning the Soviet Union's latest fighter/interceptor: the Mikoyan-Gurevich \"MiG\" Model 31, given the codename \"Firefox\" by NATO. Its capabilities seem otherworldly: total stealth, twin engines each delivering 50,000 pounds of thrust, combat ceiling 100,000-feet-plus, speed in excess of Mach 5 or even Mach 6 (and able to maintain it, no small feat), and a weapons and defense system able to read the pilot's thoughts and allow him to aim and fire his weapons without even having to press a button, thus affording him a 3- to 5-second reaction-time advantage over any opponent. NATO's descision is to send Gant in to steal a Firefox prototype right off the Soviet development base at Bilyarsk near the Ural Mountains.Gant resents the operation because he is being quite simply blackmailed; he has been allowed to live on government land which now will be sold out from under him if he does not agree to the mission. The NATO Air Force attache (Thomas Hill) resents it, too, because Gant has no experience as a spy and, worse yet, is subject to post-traumatic stress disorder and may crack at any time. They use Gant for two reasons only: he speaks fluent Russian and happens to be a perfect fit for the pressure suit worn by the MiG-31's prime test pilot, Lt. Col. Yuriy Voskov (Kai Wulff).Gant goes through several weeks of retraining, both in flying and in aerial combat, and briefings on his first required impersonation--as a corrupt businessman named Leon Sprague, known to be smuggling heroin into the Soviet Union. After his training is over he is sent to London where Aubrey gives him his final briefing on his objectives and he's disguised with a new haircut and a false mustache. Gant is also familiarized with the underground network group, who are mostly Russian Jews. Aubrey also hands him a one-way homing device disguised as a cheap transistor radio. What his handlers don't tell him, though, is that if anything compromises the mission, Gant will be left on his own.Gant lands at Sheremetyevo Airport in Moscow, blusters his way through an unannounced customs search, and manages to leave the airport--with the \"radio.\" He takes a taxi to his rooms at the Hotel Moscow, puts the radio into his pocket, and waits. Outside he sees three Soviet soldiers goose-stepping in formation while patrolling.In the meantime, at KGB Moscow Center on Dzherzhinskiy Square, Colonel Kontarsky (Kenneth Colley) of the KGB finalizes his plans to safeguard the MiG-31 prior to its trials the next day which will be conducted for the Soviet First Secretary. He also orders his second-in-command, Dmitri Priabin (Oliver Cotton), to arrest some underground members at dawn, but not to move before then. Kontarsky in fact knows all about the spy network funneling information from Bilyarsk out of Russia--but even he does not know what the CIA and the SIS really have planned.That night Gant walks out to the Krasnokholmskiy Bridge, under instructions to be there at precisely 10:30 with the KGB shadowing him -- he is ordered", "neg": "Judge Dan Haywood (Spencer Tracy) arrives in Nuremberg in 1948 to preside over the trial of four Nazi judges, each charged with having abused the court system to help cleanse Germany of the politically and socially undesirable, allegedly guilty of war crimes. The opening statement of the prosecuting attorney (Richard Widmark) is a vicious one, depicting the defendants as having been willing, evil, accomplices in Nazi atrocities, but Judge Haywood wonders if it is really that simple.Confounded at how one defendant, a renowned German champion of justice named Ernst Janning (Burt Lancaster), appears to have played the greatest role in molding Germany's Ministry of Justice into a destructive instrument of Nazism, Judge Haywood resolves to gain some perspective on the period in which the German legal system strayed from a course of entirely objective justice.Probing for the truth proves difficult, though, as nobody who lived in Germany during Nazism seems to admit to having much inside knowledge. He befriends Mrs. Bertholt (Marlene Dietrich), the widow of an executed Nazi army officer, but she offers few insights, more consumed by her personal experiences than the broader matters of Nazism. Mrs. Bertholt is focusing on being a catalyst for the cultural rebirth of Nuremberg, keen on remolding the image of a city that had become notorious as the site of the Nazi raliies. An attempt to discuss the period with his housekeepers, Mr. and Mrs. Halbestadt, who had lived near the Dachau concentration camp, proves equally fruitless for Judge Haywood, as they cannot help but focus on the loss of their child in the bombing and the fact that they nearly starved from poverty. Whether anyone knew anything mattered little, for Germans were looking forward, not backward, still grappling with, and recovering from, the hardships and losses that the war brought to them and their families.Only in the courtroom will Judge Haywood have the opportunity to gain insights into the realities of the period. First hand evidence of a) all German judges having sworn to a Nazi oath of allegiance, b) human sterilization orders signed by the defendants and carried out, and c) the execution of a Jew merely for having relations with a non-Jew, painted an evil picture of the ways in which the law had been applied by the defendants during Nazism. Still, Judge Haywood cannot fully come to grips with why these judges had been willing to enforce the law in such a horrific manner. Not, at least, until the defendant Ernst Janning feels compelled to make a statement, against the advice of his counsel (Maximilian Schell).In his statement made under oath, Janning speaks of how economically-stricken Germany had become a nation of fearful, desperate people, and how only such a people could submit to Nazism. Hitler's promises, Janning explained, in which he openly vowed the elimination of those accountable for Germany's hardships were, at first, soothing and reassuring to them. Janning then noted that, even once the complicit realized the unconscionability and inhumanity of Hitler's approach, they stayed at their posts to help things from getting even worse, but, predictably, failed to derail the atrocities of the times. He explained that national allegiance had motivated most of them to the point that they sacrificed their own personal senses of morality. In a deeply personal, yet self-damning, statement, he conceded that most of them should have known better, and that those that had gone along had betrayed Germany.At long last, the issue at the heart of the case becomes clear to Judge Haywood - the choice that the defendants had to make was between allegiance to their country and allegiance to their own senses of right and wrong. Understanding the times and context in which the actions of the defendants took place, Judge Haywood is ready to pass judgment on the defendants. He sentences each to life imprisonment, noting that their actions were illegal under both International law and German law, and further notes that they were men of sufficient intellect, prominence and credibility in Germany that their refusal to help transform the German court system into an institution that, systematically, denied justice to enemies of the Third Reich might have made a difference.As noted in", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}585{"query": "In the mean time, Maha Nawrahta opened the southern front on 23 October 1765 in three directions. He had 20,000 to 30,000 under his command. A small army invaded by the Three Pagodas Pass towards Suphanburi. Another small army invaded down the Tenasserim coast towards Mergui and Tenasserim town. However, the main thrust of his attack was at Kanchanaburi. His 20,000-strong main southern army invaded via the Myitta Pass. Kanchanaburi fell with little resistance. The main reason for the quick fall of Kanchanaburi could be that the Burmese were more battle-hardened. But it could also be that the Siamese command miscalculated where the Burmese main attack would come from, and had not sufficiently reinforced the fort to withstand a major attack. Judging by the Siamese chronicles' reporting of the main attack route, the Siamese command appeared to have believed that the main Burmese attack would come from the Gulf of Siam coastline, instead of the most obvious and shortest route via Kanchanaburi. The Siamese sources say that Maha Nawrahta's main invasion route came from southern Tenasserim, crossing the Tenasserim range at Chumphon and Phetburi. The path is totally different from the Kanchanaburi route reported by the Burmese chronicles. Historian Kyaw Thet specifically adds that the main attack route was via the Myitta Pass.", "pos": "After Alaungpaya's death, the new Burmese king Naungdawgyi was embroiled in several rebellions, including that of Gen. Minkhaung Nawrahta, and could not resume the war. The war was inconclusive. For all their work, the Burmese gained little of their original objectives. Siam very much remained a thorn to the stability of Burmese peripheral regions. In the following years, Siam continued to provide support to Mon rebels in the south who raised a major rebellion in 1762 as well as those in Lan Na in the north . The only lasting territorial gain the Burmese achieved was the upper Tenasserim coast, on which they previously had only a nominal claim. Although the Siamese troops no longer openly intruded the border, the Mon rebels continued to operate from the Siamese territory. In 1764, the Mon governor of Tavoy, who was made governor by Alaungpaya only four years earlier, revolted until it was put down in November 1764. Likewise, the instabilities in Lan Na resumed soon after the Burmese army left in February 1764, forcing the army to return again later in the year. The inconclusive nature of the war would lead to the next war in 1765.", "neg": "In 1740, the Mon of Lower Burma revolted against the Toungoo Dynasty and founded the Restored Hanthawaddy Kingdom based in Pegu . Throughout the 1740s, the Hanthawaddy forces were winning against Upper Burma-based Toungoo armies. The Siamese were concerned by another rising power in Burma since a strong Burma historically meant future invasions to Siam. Concerned, the Siamese court readily gave protection to the Burmese governors of Martaban and Tavoy who had fled to Siam. In 1745, they sent a diplomatic mission to Ava to evaluate the political situation there, and were received by the Burmese king Mahadhammaraza Dipadi. They saw an Ava court that was on its last legs. By 1751, Restored Hanthawaddy forces were closing in on Ava. The Siamese concerns about the emergence of another strong dynasty based in Pegu appeared imminent. Perhaps as a precautionary measure, the Siamese decided to move their forward base into the upper coast in 1751. While it remains unclear as to whether the Siamese ever intended to go beyond the coast into mainland Lower Burma, the Siamese action nonetheless rang alarm bells in Pegu. Deeply concerned, the Hanthawaddy leadership withdrew two-thirds of their army back down to Lower Burma immediately after they had toppled the last Toungoo king in April 1752. This redeployment of Hanthawaddy troops proved a critical turning point in Burmese history as it gave nascent Upper Burmese resistance groups much needed breathing room. The Hanthawaddy command left less than 10,000 men to pacify all of Upper Burma. Taking advantage of light Hanthawaddy troops, one resistance group, the Konbaung Dynasty led by Alaungpaya, drove out Hanthawaddy troops from Upper Burma by May 1754. Konbaung armies invaded Lower Burma in 1755, and captured Pegu in 1757, ending the 17-year-old Mon kingdom.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}586{"query": "In a New York City residence, Pierre Delacroix (Damon Wayans) rises to begin his daily routine. Brushing his teeth, he gives us by voice over a definition of satire. He tells us that with the rise of the Internet, video and interactive games, his field as a television writer has seen a drop in popularity. Meanwhile, in a dilapidated building, squatter Womack (Tommy Davidson) wakes up his friend Manray (Savion Glover) for a day of work. This consists of travelling to the CNS (Continental Network System) building where Delacroix works, and Manray tap dancing to entertain the workers. They then collect money from the workers. The men see Delacroix walk by, and ask him for monetary help in the form of work of some kind.Delacroix walks into a staff meeting late and is immediately castigated by his boss, Thomas Dunwitty (Michael Rapaport). Dunwitty informs the staff that CNS has poor ratings. He says he wants them to write funnier material, and ends the meeting. In the privacy of his office, Dunwitty tells Delacroix that the material Delacroix's been writing for him seems like it's about white people with black faces. Dunwitty asserts that Delacroix is an \"oreo\" with his Harvard education, because he won't write a \"n----r show.\"The next day, Delacroix and his assistant Sloan Hopkins (Jada Pinkett Smith) talk. They've decided that Manray is the solution to his problem. Delacroix plans to write a show that will be so \"offensive and racist,\" it will prove his point that the network only wants to see black buffoons on the air. Delacroix simply hopes to be fired, so he can be let go of his contract with CNS. Manray and Womack ask at the receptionist's desk for a \"Delapoint\" and the men working there tell them to step outside. However, Sloan steps into the lobby, sees what's happening, and escorts Manray and Womack to Delacroix's office. Delacroix explains to them that he has an idea for a television pilot, and they can make money with it. His main request is that Manray changes his name to Mantan, in an apparent homage to black character actor Mantan Moreland.On Sloan's walk home, she runs into her big brother Big Blak Afrika F/K/A Julius (Yasiin Bey). In Sloan's apartment, Julius and Sloan argue about his values, and he tells her to introduce him and his political hip-hop crew, the Mau Maus, to Delacroix.Delacroix has another meeting with Dunwitty. Delacroix proposes that the network start a variety show called \"Mantan: The New Millenium Minstrel Show.\" Delacroix says that new faces are needed for the show, and has Sloan bring in Manray and Womack. The two men, respectively renamed \"Mantan\" and \"Sleep'n Eat,\" will exhibit a range of stereotypical traits, Delacroix explains. Sloan is opposed to the proceedings, and suggests that there will be protest of the show they are planning. To seal the package, Manray dances atop a table in front of Dunwitty -- who immediately leaves to try to sell the show's concept to his executive bosses.Delacroix, Sloan and another woman hold auditions for the show. The first group of people (The Roots) audition to be the show's house band, The Alabama Porch Monkeys. After they perform, a dancer, a vulgar man shouting \"I be smackin' my hoes,\" and a didgeridoo player all audition. The next hopeful is Honeycutt (Thomas Jefferson Byrd), an actor who bungles Shakespearean quotes and proclaims \"N----s is a beautiful thing.\" Sloan's brother's group, the Mau Maus then do a fiery, confrontational performance; Pierre states via voice over that there is no place for them in his plan.Delacroix looks over a revised script for the show and confronts Dunwitty and his co-writer, Jukka about their alterations to it that even he finds racially offensive. Delacroix says that he won't be responsible for their changes, which Dunwitty says are to make the show funnier. Dunwitty says he knows black people better than Delacroix does, telling him, \"Look", "pos": "Images from the first part of Porky.Edward \"Pee Wee\" Morris (Dan Monahan) wakes up shouting \"I've been laid!\" with joy. It's the following morning, after all the events in the first part. He increases the line in his maturity chart - the one he keeps under his mattress. His penis doesn't look as responsive as always, but he thinks it may be a resting time after the novelty of sex with a woman. His mother (Ilse Erl) enters his bedroom while he's got a boner - after watching toples women at The National Geographic magazine. Mrs Morris is dumbfolded when she looks at Pee Wee's chart.Back at Angel High School, Pee Wee brags about having Wendy Williams (Kaki Hunter) snatched from everybody else. His friends tease Pee Wee, saying that Wendy didn't think it was such a big thing. Wendy wants a better man - Wendy admits that it was all a prank planned by his friends: she really ended up satisfied.The Drama Club is producing a Shakespeare-based play for a theatre festival. All the boys in the festival are participating. Pee Wee interrupts a natural sciences lesson - the vivisected frogs are disgusting. Pee Wee is blamed for a joke which was not even his, but the science teacher (Howard Neu) tells him off. Pee Wee is jealous of Wendy, who is talked about a lot. She says that she's faithful, that people will talk about her without really knowing her, and that boys will always brag about things they haven't really done. Pee Wee tries to trust her, and says that he'll kick the ass of any boy who badmouths her from that moment on.Tommy Turner (Wyatt Knight), Tim Cavanaugh (Cyril O'Reilly), Billy McCarthy (Mark Herrier) and Anthony \"Meat\" Tuperello (Tony Ganios) are part of Pee Wee's gang. They are on friendly terms with new student Johnny Henry (Joseph Runningfox), who says hello to them. He'll participate in Shakespeare's play as well, alongside with Pee Wee and Tommy.Anthony has to dress up as a god fairy, which creates plenty of mockery around, especially with Pee Wee. Later, they disguise themselves to go to a carnival to see a well-endowed girl to dance something similar to the dance of the seven veils. The boys visit Gloria , and her MC (Peter Conrad). Pee Wee wants to get out on stage with his costume. He looks like a green Puck.Ms Beulah Balbricker (Nancy Parsons) and Reverend Bubba Flavel (Bill Wiley). Mrs Morris, Pee Wee's mother was the person responsible for the play. Mr. Floyd J. Carter (Eric Christmas) cannot stand up to Flavel's shouts and screams. They allege that Shakespeare is filth. Carter dismisses them after reading romantic passages from the Bible.Pee Wee finds another girl, and he takes her to the cemetery. He runs away. It's a prank - as Pee Wee shows himself stark naked. Laura gets undressed and wraps herself around Pee Wee. It looks like Laura is choking to death. Steve and Tommy say that Pee Wee is to blame for Laura's death. They can't call Ted (Art Hindle). Steve frightens Pee Wee, dressed as a zombie. So now, they accuse Pee Wee of killing two people; he runs butt naked. Ted and another cop see Pee Wee naked running on the road, but they don't stop to pick him up. They are dumb folded by Steve's disguise, but not afraid. He passes out.Somebody (Will Knickerbocker) has thrust a dummy against Johnny Henry, a Native American, kissing a white girl. The commissioners arrive; they are Hurley (Fred Buch), Couch (Richard Liberty) and Gebhardt (Edward Winter) will support the play, in spite of the racist comments.Balbricker sings and dances Black Magic while on the toilet, but the gang plays a prank on her. They open up the pipe and push a snake up. Balbricker runs in panic with her pants", "neg": "As elderly people go about their day in Manhattan, Harry walks along a sidewalk with his tabby cat Tonto on a leash, quoting Shakespeare's \"King Lear\" as he goes. Harry stops in at a grocer, buys some good food for his cat, and jokes that his sexual days are over.Next Harry meets his old friend Jacob on a bench, and tells him that his apartment building is being torn down to build a parking lot. Jacob complains about capitalists, and reassures Harry that he could always move in with him.On the way home, a kid tries to steal Harry's groceries and knocks him down. Harry is helped up by Leroy, his building super.Harry gets into his apartment and talks to Tonto, lamenting that he's been mugged four times in the past year, and that the whole city is getting run down.Some time later, police show up to forcibly remove Harry and his furniture from the building. Harry continues to spout \"King Lear\" while his son Burt arrives to pick him up.Harry goes to live with Burt and his wife and two grown sons in the suburbs. His younger grandson, Norman, has taken a vow of silence, leading to obvious tension with his brother and parents. Harry later asks Norman for the books that explain his beliefs.Harry goes back to his familiar bench to talk with Jacob, and they both agree it's been a long time since either has been with a woman. Jacob reminisces about his first sexual encounter with a servant girl when he was 14.Harry invites Leroy to dinner at Burt's house, and he plays the piano while Leroy dances to the tune. Leroy later comments that he lives with his 90-year-old mother and can't find a new job, which leads Burt's wife to question why Harry is not getting help from his two other kids.Knowing that he is a burden to Burt, Harry goes to look for his own apartment, but finds that the place he wants will not take cats. He then tells Burt he is going to Chicago to visit Shirley, Burt's sister, but before he leaves he stops at a city morgue to identify the body of Jacob, who has died with no relatives. Harry cries after recalling Jacob's story of losing his virginity.Burt takes Harry to the airport, but Harry soon learns that he can't go through security with Tonto, so he takes a cab to get a bus. Along the route, Harry asks the bus driver to stop so that Tonto can relieve himself, whereupon the cat runs away across a cemetery. The bus driver leaves Harry behind with his luggage, and when Tonto returns, Harry scolds him.Harry walks to a used car lot and buys an old Chevy for $250. He then checks into a motel and calls Burt to tell him what has happened, realizing in the process that his driver's license expired in 1958.Harry drives west rather slowly, with Tonto on the dashboard, recalling how he wanted to drive across the country when he was younger, but his wife and kids came along. He remembers they had many good times though. He confesses to Tonto that he has a great fear of pain, and that when he dies he would like to go quickly rather than the slow way his wife Annie died.Harry picks up two young hitchhikers, one of whom soon gets another ride, while the other a girl named Ginger continues west with Harry. She claims she is 16, and is running away from home to a commune in Boulder.Harry and Ginger get a motel for the night, and after she comes out of the bathroom half-naked, Harry is prompted to recall the first girl he loved, Jessie, whom he has not seen in 50 years. Ginger suggests that they go to see her, even though it's out of their way, and they eventually find her in a nursing home.At first Harry thinks Jessie remembers him, but her thoughts are marked by senility; she calls him Alex yet remembers his wife Annie. Then she suddenly asks Harry to dance, which they do while Ginger looks on.Harry", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}587{"query": "The DRG Class 99.19 engines were metre gauge, ten-coupled, superheated, steam locomotives that were employed in the southwestern German state of Wurttemberg from 1927.", "pos": "The Caledonian Railway 179 Class (nicknamed Oban bogie) was a class of 4-4-0 steam locomotives designed by George Brittain for the Caledonian Railway (CR) and introduced in 1882.", "neg": "The Volme is a river in North Rhine-Westphalia, Germany, a left tributary of the Ruhr.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}588{"query": "Parents are lectured about the dangers of their children using marijuana with a cautionary tale of what happened to once-innocent kids became addicted to the drug: their mind alterations lead to a car accident, a shooting, and an innocent boy being brought to trial.--------------------------------------------------Synopsis written by KrystelClaire:A long written essay against marijuana.Newspaper reels and first pages telling of how the police is tackling the issue of the marijuana war. In one of them, there is an advertisement telling parents to attend Alfred Carroll (Josef Forte)'s lecture at the School-Parents Association in Truman high school auditorium. He mentions that marijuana was grown in a tenement court in New York.Cut to Mae (Thelma White) who is woken up rudely by Pete Daley (Richard Alexander) who wants to lure kids into criminality. Three friends separate. Ralph (Dave O'Brien) points to some attractive young women. The girl Ralph wants most is Jimmy Harper (Warren McCullom)'s sister. Bill (Kenneth Craig) thinks she's interested as well. They go to a jazz place, where Mae sits uncomfortably as she knows that the real objective is to lure kids into drugs. The audience can see Ralph smoking like crazy in a separate room. The say goodbye to Joe (Lester Dorr), the bartender.Mary (Dorothy Short) takes Jimmy home, where Mrs Lane (Mary MacLaren) is happy to see them performing Shakespeare in a ridiculous way. When they kiss, she intervenes. Jimmy says goodbye and falls into a fountain garden. Junior (Bob Burns) laughs about Jimmy having a girlfriend.Ralph and Jimmy go partying. Mae distributes marijuana cigarettes - her husband is delighted that he already has a new kid in the bag: Jimmy. Mary encourages Jimmy to smoke. Ralphs laughs like a maniac: he knows he's succeeded. He goes to see Jack (Carleton Young), who thinks that kids are the best prey - now we would consider young adults, he doesn't mean children. Jimmy drives while high on dope. He scares Jack with his reckless driving and runs over a man.When Jimmy arrives home, it's dinner time. He is shocked, and tired, and his sister notices, but not his mother. Mr Wayne (Edward Earle) thinks that there marijuana is not as dangerous as other drugs, in spite of Mr Carroll's insistence.Jimmy's grades are much worse. Dr Carroll tries to make him confide on him, but Jimmy says that he's worried about a home problem, and just leaves. Mary doesn't play tennis. Jimmy dances at Mae's while he's high. Jimmy makes love to a girl while Ralph laughs like a maniac.The police questions Jimmy's sister if she used her car on the 29th. Mary lies to protect him. Joe gives Mary the address where Jimmy is. Mary sits to wait for Jimmy, and Mae's husband offers her a marijuana cigarette, which she smokes without realising it's not tobacco she's using. Mary starts laughing for no reason. Mary rejects Pete Daley), but Jimmy, completely doped, at first believes that they are making love. When he intervenes, there is a fight between Ralph and Jimmy. In the ensuing fight, the gun which Ralph uses goes off and kills Mary. Ralph dusts the gun off and puts it into Jimmy's hand, who's still doped. When they wake him up, they make him believe that he killed Mary.Jack prepares an alibi for himself. Carroll declares in front to the judge and jury that he's seen Jimmy very much changed, and that marijuana was to blame. The Judge (Edward LeSaint) presides. The jurors (Marin Sais, Phil Dunham) stare at the declarations in shock. Blanche (Lillian Milles) feels sorry for Jimmy, but Jack tells her to shut up.The prosecuting attorney (William Royle) blames marijuana as the cause of the murder. Jimmy is in shock. One of the jurors thinks that Jimmy may have been insane, but the foreman (Frank O'Connor) makes a case for all the opposite: they want to hang Jimmy Harper as soon as possible", "pos": "Cristina Moreno (Shelbie Bruce - Aimee Garcia as narrator) is applying to Princeton University. For her application essay, she tells the story of her childhood and narrates throughout the movie. Flor Moreno (Paz Vega) is a poor Mexican single mother who moved to America to have a better life for her and her daughter, Cristina (Shelbie Bruce). When she could not maintain her two jobs due to the safety of her daughter, Flor's cousin takes her to a job interview as a nanny for the Claskys, consisting of John (Adam Sandler) and Deborah Clasky (Tea Leoni), their children Bernice (Sarah Steele) and Georgie (Ian Hayland), and Deborah's mother Evelyn Wright (Cloris Leachman). John is a man who cares about cooking good food and raising his kids. Deborah is a former businesswoman turned stay-at-home mother, and Evelyn is a raging alcoholic. Deborah is uptight and her neurotic behavior often upsets the family: she mentally abuses her daughter to exercise by buying her smaller-sized clothes and putting her down for certain behaviors, and she mentally abuses her husband by telling him to co-parent with her on their son, but she really wants him to be submissive to her parenting instead. John is more laid back and supports the mental well-being of his children, but he feels he cannot stand up to Deborah on her parenting and often leaves it as it is. Summer comes and Flor is needed 24/7 at the Claskys' summer home. Unable to communicate well in English, Deborah finds a neighbor to interpret. Flor admits she is unable to maintain these hours because she has a daughter; out of desperation to keep Flor as their nanny, Deborah invites Cristina to come stay with them, acting as interpreter for her mother. Deborah immediately becomes attached to Cristina when she first arrived due to her beauty and begins to treat her more like a daughter than Bernice, taking Cristina shopping, buying her gifts, and getting her hair done. To make Cristina feel more comfortable, John gives the children a small glass-collecting project in which they receive money and includes Cristina. She was given $640 for her glass collection, which Flor finds out. The two argue with Cristina as the interpreter, and Flor wants to leave because of the awkwardness it will create afterwards, but John coaxed her into staying. She begins to learn English so she can communicate better with the Claskys. In the meantime, John opens a new restaurant, but falls into a temporary depression because of the stress of the business, and Deborah is having an affair, dressing provocatively and leaving only at nighttime. She enrolls Cristina into a private school with Bernice, upsetting Flor, who wants Cristina to keep in touch with her Mexican roots and working-class values. She feels Deborah is overstepping her bounds and voices her objection to John, who tells her he is just as stressed because Bernice has no support system from her own mother. Summer is over and it is Cristina's and Bernice's first day of school; that afternoon, Cristina was allowed to bring friends back to the Clasky's home from school, but not Bernice. Deborah tries to cover for Cristina to keep her there, but an angry Flor marches to her place. The now-sober Evelyn realizes that her daughter is having an affair and that her marriage is in trouble. She pleads with Deborah to end the affair, telling her she will never get another man as good as John. Deborah confesses to John that she cheated on him and begs him to stay so the two could talk everything over; however, John walks out and bumps into Flor, who was trying to tell him that she is quitting. He offers to give Flor a ride in his car, but he wanted to \"hang out\" when they arrived at her bus stop, and they ended up going to his restaurant, where he cooks for Flor. They become extremely close to the point of falling in love, but Flor is afraid of the consequences of having an affair while they both have kids. While the two enjoyed the", "neg": "The film opens in the early 1970s in front of the Quick Stop Groceries and the Record Rack stores in Leonardo, NJ. A kindly mother leaves a stroller with her toddler son, Bob, in front of the store while she goes inside to buy food. She gives the boy a baseball cap that she puts on his head with the visor turned backwards. Another mother, more foulmouthed and demeaning toward her own toddler, Jay, leaves her stroller in front of the store while she goes into the record store to score drugs. A man walks out & asks her who'll be watching the kids while their mothers are inside. The woman lets loose with a torrent of foul language, laced liberally with the F-word, attacking the man for questioning how she raises her kid. The guy walks away, disgusted The child of the foul-mouthed mother stands up in his stroller and begins to recite the F-word in rhythmic fashion and the scene dissolves to the two boys as young adults; they have grown up to become the foul-mouthed Jay and his taciturn companion, Silent Bob. The duo stand in front of the stores (the Quick Stop is still there but the record store has changed to RST Video) most days and deal drugs. When a couple of teenagers approach them, Jay launches into a rap sales pitch reminiscent of Morris Day & the Time's \"Jungle Love\". When the younger teen derides the song, Jay grabs him and threatens him. From the video store, Randal Graves appears and tells Jay and Bob to let the kid go and that the Time sucked anyway. Jay tells the two buyers that Randal and his coworker, Dante Hicks, are both a gay couple and that their wedding ceremony was Star Wars-themed. Randal says he'll do something that should've been done long ago: he calls the police. Jay and Bob are arrested after Jay mouths off to the cop.Jay and Bob go to the comic book store that bears their name to talk to Banky. They've been slapped with a restraining order that forbids them to go to either Quick Stop or RST. Banky tells them both that they shouldn't have to bother selling drugs anymore because of the royalties they received when the comic series they inspired, Bluntman and Chronic, was sold to a major motion picture studio. The two are stunned, saying they didn't know about the deal. Banky tells them both that they should talk to his old business partner, Holden McNeil, who brokered the deal after he'd bought Banky out of his share of the original comic.The two go to Holden's offices and confront him about the movie. Holden tells them that Banky had lied to them and had brokered the deal, leaving Holden with nothing. He also says that the buzz on the internet is that the movie will be very profitable. Jay and Bob are both clueless as to the existence of the internet and Holden shows them an example of a forum website where fans and non-fans of Bluntman and Chronic are sharing their views on the unfinished film. Jay and Bob are furious at the negative buzz and make it their mission to go to Hollywood and stop the production of the film.Without a car, the two decide to hitchhike. After receiving advice from an expert hitchhiker where he tells them to perform sexual favors for rides, the two are picked up by a nun. She throws them both out of her car when Jay suggests that the Rules of the Road require him to pay her with oral sex. Stranded in front of a Mooby's restaurant, they go inside to get something to eat. They find an internet station and launch a foul-mouthed response to their detractors on Moviepoopshoot.com. While they order their food, a beautiful woman, Justice, walks in. Jay is immediately smitten and imagines kissing her to Bon Jovi's \"Bad Medicine.\" After they introduce themselves, they hitch a ride with Justice and her two companions, Chrissy and Sissy. Also joining them is a geeky guy with a guitar, named Brent. Justice tells them that she and her comrades are animal rights activists who travel", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}589{"query": "(Because the film has a very complicated plot and features many characters, the events will be told mostly in chronological order to render the plot clearer, rather than strictly adhering to the order we see in the film.)General Sternwood has two daughters: the elder one is Vivian (Lauren Bacall) and the younger one is Carmen, who is a carefree, childish and problematic young woman.General Sternwood has a man named Sean Regan working for him. With the help of Sean, the general has made a man named Joe Brody leave Carmen alone, by giving him 5.000 Dollars.Carmen loves Sean but Sean loves the wife of a man named Eddie Mars, so he refuses Carmens advances. One day, Carmen kills Sean when she is drunk because of her unrequited love. Eddie hides Seans body. He then makes up the story that Sean and his wife have run away together and nobody sees Sean after that day. To support this story, he actually makes his own wife go away and start living in a remote place. Even the general doesnt know Seans whereabouts and wonders why he has left all of a sudden. Eddie then proceeds to blackmail Vivian for Carmens murder. As a way of eliciting money from Vivian, Eddie makes her win big money at his gambling house with cheats, and then he takes all the money from her.Carmens troublesome adventures are not over, though. A man named Arthur Gwynn Geiger blackmails General Sternwood to take the gambling debts of Carmen. The general hires Philip Marlowe (Humphrey Bogart) to get rid of Geigers blackmail. Vivian talks to Marlowe, thinking that her father has actually hired him to find Sean Regan. Afraid that Carmen may get into trouble, she tries to take words from Marlowes mouth about his inquiry. But she learns that her father has not actually hired Marlowe about Sean.Marlowe goes to Geigers so-called antique books shop and sees a woman named Agnes, who makes it impossible for him to talk to Geiger. Then Marlowe waits at the bookshop across the street until the evening and follows Geiger and his right arm Carol Lundgren to Geigers house. Before Marlowe gets in the house, however, important things happen. Owen Taylor, driver for the Sternwoods, is in love with Carmen. He goes to Geigers house with her and kills Geiger for her. A secret camera, however, takes Carmens photo just at the moment of the murder. Owen then takes the film from the hidden camera, gets in the car and goes away. Joe Brody, also present that night, follows Owen, takes the film from him to blackmail Carmen, (and most probably) kills Owen and pushes his car in the water.When Marlowe gets in Geigers house, he sees Carmen with the dead body of Gaiger lying on the ground. Marlowe takes Carmen home and tells Vivian to say that Carmen has been home all night if asked by anyone. When he goes back to Geigers house, he sees that his dead body has been taken away.Later, Owens dead body is found in the car in the water. He has been killed before falling into the water. Marlowe learns from Vivian that Owen was interested in Carmen. Vivian then tells Marlowe that somebody is blackmailing her for Carmens photo taken at the night of Geigers murder. The blackmailer, who wants 5.000 Dollars, is actually Agnes. It is Joe Brody that makes her blackmail Vivian. Vivian tells Marlowe that she can take the money from Eddie.When Marlowe meets with Carmen once again at Geigers house, she tells him that it was Joe who took her photo that night. Eddie comes along and tries to scare Marlowe out of his inquiries.Later, Marlowe finds Joe Brody and questions him about Geiger. Agnes and Vivian are also at his house. Carmen comes along with a gun and threatens to kill Joe if he doesnt give her the photo. Carmen takes the photo and she leaves with Vivian. Then the doorbell rings again and somebody kills Joe, then escapes. Marlowe catches the man, who turns out to be Carol (Geigers right arm), who thinks that it was Joe who killed Geiger. Marlowe and Carol then go to", "pos": "Vanessa Snyder (Alexa Vega) is an admired eighth-grader in her school. She has a loving single mother, Barbara (Lisa Vidal), who is proud of her well-placed daughter. Vanessa is also \"in\" with the popular clique, led by her best friend Stacy Larson (Leah Pipes), the queen bee, and Nikki Rodriguez (Elizabeth Rice), who is secretly jealous of Stacy and Vanessa's closeness. On the exterior of this exclusive friendship circle is the outsider, Emily (Shari Dyon Perry), and the wannabe, Tiffany (Alicia Morton), who is dying to make it into the pack.The nightmare begins when Nikki tricks Vanessa into getting close to Tony (Chad Biagini), a boy whom Stacy (and somewhat Vanessa) has a crush on. A web of lies, nasty rumors, and manipulation ensues, and Vanessa is ostracized by the clique for \"backstabbing\" Stacy. Helpless, Vanessa soon faces the conflict and violence from her former friends and other popular girls whom she doesn't even know. Nikki gets Tiffany accepted into the clique, and Tiffany becomes Nikki's sidekick at poisoning the others against Vanessa. Although Nikki is the main girl who is tormenting Vanessa, Stacy plays her part by pretending she's still Vanessa's best friend and not stopping the attacks on her. Vanessa is slowly pushed out of class activities, called names, socially isolated and worst of all, her tormentors create a webpage about her on which they put humiliating photos of Vanessa, along with expressions of hatred towards her.Emily tries to convince Vanessa not to go running back to the clique, but Vanessa keeps attempting to seek reconciliation with Stacy, to disastrous results. The bullying escalates, with Stacy, Nikki, Tiffany and others cornering Vanessa inside a bathroom and verbally brutalizing her, including degrading every aspect of her and revealing her embarrassing secrets. That night, Vanessa has a nervous breakdown and chops all her hair off. Then she starts skipping school, fearing the agony in the hallways. Stacy offers a fake truce to Vanessa and asks for help on an assignment. Vanessa sends Stacy her paper, only to have Stacy copy it and make it look like Vanessa copied Stacy's paper.Once Vanessa shows her mother a print-out of comments about Vanessa's hair, Barbara tries to help by informing the school about the bullying, to no avail as the principal is unable to take disciplinary action against non-physical bullying. Barbara even tries to talk to Stacy's mother, Denise (Rhoda Griffis) but only ends up straining their friendship. Even an adult like Barbara is helpless in the face of teen violence.Vanessa's spirits are suddenly lifted when Stacy invites her to her birthday party. After preparing, she arrives at a club, which is not the site of the party. When discovering this, Vanessa goes ballistic. She takes an overdose of her mother's sleeping pills, but survives and just passes out.In the hospital, Barbara reveals to her daughter that she was also emotionally bullied when she was a teenager, which caused her to encourage Vanessa to stay friends with Stacy. She says that she never dealt with it herself and wished Vanessa would learn self-defense.During a class session, Emily accuses Stacy of nearly killing Vanessa for her actions. She is also the only one of Vanessa's classmates to visit her in the hospital and befriends her.Back home, Barbara spots malicious instant messages popping up on Vanessa's computer and sends them to the school principal. The culprits have been revealed to be Nikki, Tiffany, and Ezra (Joey Nappo), another tormentor. If they deny that they cyber-bullied Vanessa, they would be expelled from the school and not graduate. When Vanessa returns to school, she and Stacy reunite after Stacy convinces her that she's sorry about the bullying. They IM each other about how great it feels to be best friends again. Then graduation day comes and the final conflict happens when after the graduation, Nikki and Tiffany read aloud the chat between Vanessa and Stacy, which Stacey had sent to Nikki, and which Nikki had printed out.", "neg": "Paul Stanton (Mulroney) and his wife Diane (Diane Kruger) are a couple whose daughter is dying from a rare degenerative lung condition. The only thing that can save her life is a lung transplant from an organ donor. The movie starts when the donated lung fails to arrive correctly. The movie goes back and forth between the present and the events leading up to it. In the present day, Paul goes to Juarez, Mexico to find a man called Dr. Navarro. After leaving his cell number at many local hospitals, somebody finally contacts Paul. In the past, Dr. Rubin (Arquette), who's treating their daughter (Stallard), had given them information regarding Paul's associate, Harrison (Shepard), who somehow managed to get an organ transplant for himself, possibly from the black market. Paul confronted Harrison and finally managed to get Dr. Navarro's name from him. Harrison told him that he was contacted by Navarro and he didn't know how to reach him. Back in the present day, Paul is ambushed by a couple of Navarro's guys that tell him to stay away. After an arduous search, Paul finally finds out that Dr. Navarro is actually Dr. Martinez (Perez) from a local hospital that he visited previously for his wounds. Paul confronts Martinez and asks him to find a lung donor for his daughter, who only has one week to live. Martinez agrees to help him for a $250,000 cash payment. The next day, Martinez tells Paul that he has found a matching donor for his daughter. Paul tells Diane to go to Juarez and prepare their daughter for the transplant operation. Little does Paul know that the donor is actually a live person; Martinez and his men have planned a hit-and-run accident to get the lung implant from a local street boy. Paul discovers this fact and tells Diane about it. Diane tells him that she does not want to know where the donor comes from. Paul confronts Martinez at the operating table. Martinez tells Paul to make a choice: to go ahead with the operation or disband the operation knowing that they won't be able to find another match in time to save his daughter's life. The next scene shows Paul and Diane at their daughter's funeral. Diane gives Paul an accusing look blaming him for their daughter's death. Meanwhile, elsewhere, the local boy that was supposed to be the organ donor is alive and playing soccer with his friends.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}590{"query": "The film is based on the Auguste Le Breton novel, Du rififi chez les femmes, published in 1957 and reprinted in 2010.", "pos": "Making Plans for Lena (French: Non ma fille, tu n'iras pas danser) is a 2009 French film directed by Christophe Honore, who co-wrote the screenplay with Genevieve Brisac.", "neg": "Min and Bill is a 1930 American Pre-Code comedy-drama film starring Marie Dressler and Wallace Beery and based on Lorna Moon's novel Dark Star, adapted by Frances Marion and Marion Jackson.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}591{"query": "Food Force is an educational game published by the United Nations World Food Programme (WFP) in 2005.", "pos": "Cafeteria Nipponica is a simulation video game developed and published by Kairosoft for the Android and iOS operating systems.", "neg": "Yana De Leeuw (born 6 September 1990) is a Belgian female former volleyball player, playing as a setter.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}592{"query": "One day, a brave jackal came to the river to drink some water. He saw a lion looking weak and tired, and asked, \"What is the matter, King of the Jungle?\" The lion told the jackal his story. The jackal felt sorry for the lion. He pulled and pulled at the lion's tail until the lion became free. The lion was very happy and said, \"Thank you so much for helping me. I thought I would die! You are my friend for life! I would like you to come and live with me. From now on, I will hunt and share my food with you.\" The jackal moved in with the lion's family and had a wonderful time. Soon, the lion had children of his own and so did the jackal. The lioness was not happy about the friendship. She complained to her children. Her children complained to the jackal's children; the jackal's children complained to their mother and their mother complained to the jackal. The jackal was upset and told the lion, \"You told me to live with you. If you don't like it any more, you should have said so yourself.\" The lion was shocked and said, \"This is not true. I've never complained about you. I still want you to continue staying with me.\" The jackal said, \"We understand each other. But our families don't. Perhaps it is better for us to live apart, but continue meeting each other when we are free. We can even hunt together!\" The two families parted, but the lion and the jackal met often and remained friends for the rest of their lives. From the above paragraphs, we can conclude that in order to keep our good friendship, we have to give something up or give in in some particular cases. However, we can never give up or destroy our families. What do you think of it?", "pos": "The film opens where the previous film ended, set a few years later, where Rafiki (Robert Guillaume) gathers the animals of the Pride Lands together for the presentation of Simba (Matthew Broderick) and Nalas (Moira Kelly) new daughter Kiara. Mufasa's spirit (James Earl Jones) watches over the ceremony. Later, Simba becomes very overprotective of an older Kiara (Michelle Horn), assigning Timon and Pumbaa (Nathan Lane and Ernie Sabella) to watch her. One day as Kiara was playing, she fell into a small pond as Timon and Pumbba got her back onto land. Kiara tells them only half of her is a princess. Pumbba asks, \"Well, who's the other half?\" While they wait for her to answer, they start having a snack. Then they started arguing about slimy and crunchy grubs. While they were arguing, Kiara sneaks into the \"Outlands\" where she meets a young cub named Kovu (Ryan O'Donohue). After escaping a river filled with nile crocodiles, the two become friendly, unaware they are being watched by Kovu's mother, Zira (Suzanne Pleshette). Simba arrives and confronts Zira, who reminds Simba that he exiled the Outsiders, and that if he wants to punish them, Kovu is Scar's hand-chosen successor. Unwilling to harm the cub, Simba orders them to leave. Later Simba scolds Kiara for endangering herself. In the Outlands, Zira's eldest son, Nuka (Andy Dick), complains to his younger sister Vitani (Lacey Chabert) about Kovu's status as \"the Chosen One\" the cub chosen by Scar to lead the pride after his death. (\"I should've been the \"Chosen One\". I'm the strongest, I'm the smartest, I'm the oldest, etc.\") At that moment, Zira returns and scolds both of her sons, but Kovu accidentally gives her the idea to use Kovu's new friendship with Kiara as a means of exacting her revenge on Simba for Scar's death. Now an adult, Kiara (Neve Campbell) heads out from home for her first solo hunt, however Simba again sends Timon and Pumbaa to follow and watch her progress after he promised to let Kiara hunt on her own. Furious to find out her father still insists on maintaining surveillance, Kiara goes further from home to hunt, though is still unsuccessful in her efforts. Meanwhile, Zira's plan to implant Kovu in Simba's pride has been set in motion; Nuka and Vitani (Jennifer Lien) set fire to the plains where Kiara is hunting, causing her to faint and giving Kovu (Jason Marsden) the chance to rescue her. Drawn by the smoke, Simba finds them together and reluctantly accepts Kovu's request to come to Pride Rock in return for saving Kiara's life, though he forces Kovu to sleep outside. That same night, Simba has a nightmare about his father's death, where Scar suddenly morphs into Kovu and Simba takes his father's place falling off the cliff. The next morning, he goes outside to a watering hole where Kovu contemplates attacking him, but Kiara interrupts and they go off together so Kovu can help her learn how to hunt. Kiara kept on failing. During the lesson, Kovu was setting an example for Kiara, thinking Timon was just an ordinary meerkat. They run into Timon and Pumbaa struggling with some birds, so the two lions help them chase the birds off. Together, they have fun playing, something Kovu notes he has never experienced before. That night, Kovu tells Kiara that he is not Scar's real son, but \"was a part of him\". Simba watches from above, seeking guidance from the \"Great Kings\" and Nala advises him to give Kovu a chance, because he is not his father. Kovu decides to leave after he almost confesses his real intentions to Kiara, but Rafiki stops him and invites the young lions to experience \"Upendi\" love. After a musical journey through the jungle, the two fall in love. In the morning, Simba invites Kovu for a walk and tells him the true story of", "neg": "There was once an ant that was very thirsty. It ran here and there looking for some water but could not find any. Then suddenly, when the ant was almost ready to die of thirst, a large drop of water fell on it. The ant drank the water, which saved its life. The water was actually a tear from a young girl who was crying. Because of her sadness, the tear had magical qualities and suddenly the ant could speak the language of human beings. The ant looked up and saw the young girl sitting in front of a huge pile of seeds. \"Why are you sad?\" asked the ant. \"I'm the prisoner of a giant.\" the girl told the ant. \" He won't let me go until I've made three separate heaps of grain, barley and rye out of this huge pile of seeds in which they are all mixed together.\" \"That will take you a month!\" the ant said, looking at the huge pile of seeds. \"I know,\" the girl cried, \"and if I haven't finished by tomorrow, the giant will eat me for his supper!\" \"Don't cry,\" the ant said, \"my friends and I will help you.\" Soon thousands of ants were at work, separating the three kinds of seeds. The next morning, when the giant saw that the work had been done, he let the girl go. Thus it was one of her tears that saved her life.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}593{"query": "Susana Machado Bernard House and Barn is an elaborate 10,000-square-foot (930 m2) Art Nouveau Gothic Revival style mansion and carriage house located in the Pico Union section of Los Angeles, California.", "pos": "The Eastern Columbia Building, also known as the Eastern Columbia Lofts, is a thirteen-story Claud Beelman designed Art Deco building located at 849 S. Broadway in the Broadway Theater District of Downtown Los Angeles.", "neg": "He retired to the Villa Bianca (now named ''Villa Grock''), a 50-room house he had had built in the 1920s in Imperia, Italy, where he died in 1959.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}594{"query": "Paul MacDermid (born April 14, 1963 in Chesley, Ontario) is a retired professional ice hockey right winger who played 690 games in the National Hockey League (NHL) for the Hartford Whalers, Winnipeg Jets, Washington Capitals, and Quebec Nordiques.", "pos": "Glen Seabrooke (born September 11, 1967) is a retired Canadian professional ice hockey player who spent parts of 3 seasons in the National Hockey League (NHL) in the 1980s with the Philadelphia Flyers.", "neg": "The Seattle Metropolitans were a professional ice hockey team based in Seattle, Washington which played in the Pacific Coast Hockey Association from 1915 to 1924.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}595{"query": "Gabriel Bourque (born September 23, 1990) is a Canadian professional ice hockey player who is currently playing for the Nashville Predators in the National Hockey League (NHL).", "pos": "Marcus Foligno (born August 10, 1991) is an American-Canadian professional ice hockey player, who plays for the Buffalo Sabres of the National Hockey League (NHL).", "neg": "The Life Before This is a 1999 Canadian film directed by Jerry Ciccoritti.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}596{"query": "Sumu-Epuh apparently was killed in c. 1780 BC during his fight with Shamshi-Adad, his successor was Yarim-Lim I, his son by his queen Sumunna-Abi.", "pos": "Niqmi-Epuh, also given as Niqmepa (reigned c. 1700 BC -- c. 1675 BC - Middle chronology ) was the king of Yamhad (Halab) succeeding his father Yarim-Lim II", "neg": "Hatra defeated the Iranians at the battle of Shahrazoor in 238, but fell to the Iranian Sassanid Empire of Shapur I in 241 and was destroyed.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}597{"query": "Bilal Rifaat (born 27 September 1957) is an Egyptian fencer.", "pos": "Shurooq Amin was born in Kuwait in 1967 to a Kuwaiti father and a Syrian mother.", "neg": "Milan Sablik (Czech pronunciation: (mlan sablik); Zdar nad Sazavou, 14 March 1991) is a Czech speedskater and the younger brother of Martina Sablikova, the 2007 European Champion and double World Single Distances Champion.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}598{"query": "Hello, Listeners. Welcome to Henton Hospital Radio. Before our music programme at four, I'm going to repeat some of our hospital rules. The hospital can sleep 800 patients. There're 8 beds in each ward . The visiting hours are in the afternoon from 2:30 to 3:30 and in the evening from 7:00 to 8:00. But remember only two people can see you at the same time. Sorry about that, but you can see what would happen if we didn't have these rules. The other rules are about our hours. We start quite early---you might not be used to that. We wake you at 6 o'clock, and breakfast is at 8 o'clock, lunch is at noon. There's tea at 3:30 and supper is at 6 o'clock. You can see the non-smoking sign---we don't allow smoking in the wards. I'm sure you understand why. However, if you do need to smoke, there are some smoking rooms where it is allowed. You will find the radio switch on the wall near your bed, with your own headphones, if you want to listen. It's our own hospital radio wishing you a quick recovery.", "pos": "The parents of a troubled teen may feel unsure as to whom to turn to in order to find help for their child. They may feel as if they have exhausted all of their options, and sometimes they are on the verge of giving up. But there is hope. Schools for troubled teens offer discipline and in some cases, drug treatment programs that can provide important life skills, and more importantly, a fresh start. The following is a list of the most effective types of schools for troubled teens. Not every facility is a match for every child, but by knowing the differences between them, parents can make a better educated decision about where to send their teenager. Boarding Schools When a child is unable to deal with the relative freedom of a standard school day, boarding schools might be a good choice. At boarding schools, the child lives in a dorm setting, where almost every minute of the day is scheduled by school administrators. Treatment Centers When a teenager has an addiction to drugs or alcohol, a residential center that specializes in young people is an outstanding way to help them break the cycle of addiction. Treatment centers feature individual and group counseling to help identify the root causes of the drug problem and help develop the life skills needed to stay clean when the program is over. Wilderness Programs Designed to help improve the discipline and self-reliance of the child, wilderness programs send kids back to nature. By placing them in a foreign and sometimes uncomfortable setting, wilderness programs hope to improve children's behavior. Programs generally include hikes, exercise programs and team building exercises. Boot Camps Boot camps are the most extreme style of school for troubled teens. These facilities are modeled after actual military boot camps, where the individual must get into shape, work as part of a team, and follow a long, hard set of rules and regulations. However, boot camps might not be the best choice for a teen with a drug addiction.", "neg": "The aim of this study was to assess to what extent patients with meticillin-resistant Staphylococcus aureus (MRSA) at respiratory sites shed viable MRSA into the air of hospital rooms. We also evaluated whether the distance from the patient could influence the level of contamination. Air sampling was performed directly onto MRSA-selective agar in 24 hospital rooms containing patients with MRSA colonization or infection of the respiratory tract. Samplings were performed in duplicate at 0.5, 1 and 2-3 m from the patients' heads. Clinical and environmental isolates were compared using antimicrobial resistance patterns and pulsed-field gel electrophoresis. MRSA strains were isolated from 21 out of 24 rooms, in quantities varying from between 1 and 78 cfu/m3. In each of the 21 rooms, at least one of the environmental isolates was identical to a clinical isolate from the patient in that room. There was no significant difference in MRSA counts between the distance from the patient's head and the sampler. This study demonstrates that most patients with MRSA infection or colonisation of the respiratory tract shed viable MRSA into the air of their room. The results emphasise the need to study MRSA in air in more detail in order to improve infection control recommendations.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}599{"query": "GNU LibreDWG is a software library programmed in C to manage DWG computer files, native proprietary format of computer-aided design software AutoCAD.", "pos": "DaDaBIK is a commercial software (formerly GPL) written in PHP for quickly creating a CRUD (create, read, update, delete) database front-end or a simple database-driven application without coding.", "neg": "This tryptch is missing a panel, lost when it was disassembled in 1777, but the panel with St. Anthony Beaten by Devils is currently on display at the Pinacoteca Nazionale.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}600{"query": "Imatinib mesylate is a tyrosine kinase inhibitor with high affinity for the BCR-ABL fusion protein expressed by the hematopoietic cells in chronic myelogenous leukemia (CML). Some patients with chronic-phase or accelerated-phase CML either relapse after an initial response or are refractory to imatinib, prompting us to evaluate the efficacy of dose increase in such patients. Twelve chronic-phase patients initially receiving 400 mg/day and 4 patients with accelerated phase initially receiving either 400 mg/day (two patients) or 600 mg/day (two patients) had their dose increased (14 to 800 mg/day and 2 to 600 mg/day) because of progressive disease (usually clonal evolution) or inadequate cytogenetic response after at least 1 year of therapy. Six patients had major cytogenetic responses after dose increase (3 complete and 3 partial). Two others had minor cytogenetic responses. Two patients with clonal evolution transiently lost the additional clonal aberrations. Almost all of the responses occurred within 6 months, and were typically 3-6 months in duration. However, 3 patients have continuing major cytogenetic responses of >18 months duration. Dose increase was well tolerated, with thrombocytopenia, mild leukopenia, and exacerbation of prior edema being the most common adverse events. Although increasing the dose of imatinib can benefit a subgroup of patients with CML with either an inadequate cytogenetic response or disease progression, our results suggest the majority will not have a sustained meaningful response, and that other options, such as allogeneic stem cell transplant or investigational therapies, also need to be considered at the time of dose increase.", "pos": "Chronic myeloid leukemia (CML) is a progressive and often fatal myeloproliferative neoplasm. The hallmark of CML is an acquired chromosomal translocation known as the Philadelphia chromosome (Ph), which results in the synthesis of the breakpoint cluster region-Abelson murine leukemia (BCR-ABL) fusion oncoprotein, a constitutively active tyrosine kinase. The introduction of imatinib, a tyrosine kinase inhibitor (TKI) that is specific for BCR-ABL, was a major breakthrough in CML therapy. Although most patients respond to first-line imatinib therapy, some experience loss of response (resistance) or require treatment discontinuation because of toxicity (intolerance). For patients with CML, failure on standard-dose imatinib therapy (400 mg daily), imatinib dose escalation (600-800 mg daily) is a second-line option. However, high-dose imatinib is not an appropriate approach for patients who experience drug toxicity, and there remain questions over the durability of responses achieved with this strategy. Alternative second-line options include the TKIs dasatinib and nilotinib. A substantial amount of long-term data for these agents is available. Although both are potent and specific BCR-ABL TKIs, dasatinib and nilotinib exhibit unique pharmacologic profiles and response patterns relative to different patient characteristics, such as disease stage and BCR-ABL mutation status. To optimize therapeutic benefit, clinicians should select treatment based on each patient's historic response, adverse-event tolerance, and risk factors.", "neg": "The objective of this study was to analyze the expression levels of multiple components in the mammalian target of rapamycin (mTOR) signaling pathway in radical nephrectomy specimens from patients with metastatic renal-cell carcinoma (RCC) treated with mTOR inhibitors in order to identify factors predicting susceptibility to these agents. This study retrospectively included a total of 48 consecutive patients undergoing radical nephrectomy, who were diagnosed with metastatic RCC and subsequently treated with an mTOR inhibitor (everolimus or temsirolimus) as either first- or second-line systemic therapy. Expression levels of 5 molecular markers involved in the signaling pathway associated with mTOR, including PTEN, phosphorylated (p)-Akt, p-mTOR, p-p70 ribosomal S6 kinase, and p-4E-binding protein 1 (4E-BP1), were measured by immunohistochemical staining of primary RCC specimens. Of several factors examined, bone metastasis, liver metastasis, and the expression level of p-4E-BP1 were shown to have significant impacts on the response to the mTOR inhibitors. Progression-free survival (PFS) was significantly correlated with the expression levels of PTEN and p-4E-BP1 in addition to the presence of bone metastasis on univariate analysis. Of these significant factors, p-4E-BP1 expression and bone metastasis appeared to be independently associated with PFS on multivariate analysis. These findings suggest that it would be useful to consider the expression levels of potential molecular markers in the mTOR signaling pathway, particularly p-4E-BP1, as well as conventional clinical parameters when selecting patients with metastatic RCC who are likely to benefit from treatment with mTOR inhibitors.", "instruction": "Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage."}601